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https://www.readbyqxmd.com/read/29331245/outsmart-hpv-acceptability-and-short-term-effects-of-a-web-based-hpv-vaccination-intervention-for-young-adult-gay-and-bisexual-men
#1
Annie-Laurie McRee, Abigail Shoben, Jose A Bauermeister, Mira L Katz, Electra D Paskett, Paul L Reiter
BACKGROUND: Effective interventions to promote human papillomavirus (HPV) vaccination are needed, particularly among populations at increased risk of HPV-related disease. We developed and pilot tested a web-based intervention, Outsmart HPV, to promote HPV vaccination among young gay and bisexual men (YGBM). METHODS: In 2016, we recruited a national sample (n = 150) of YGBM ages 18-25 in the United States who had not received any doses of HPV vaccine. Participants were randomized to receive either standard HPV vaccination information (control) or population-targeted, individually-tailored content (Outsmart HPV intervention)...
January 10, 2018: Vaccine
https://www.readbyqxmd.com/read/29328161/ultrafast-and-low-power-crystallization-in-ge1sb2te4-and-ge1sb4te7-thin-films-using-femtosecond-laser-pulses
#2
Smriti Sahu, Rituraj Sharma, K V Adarsh, Anbarasu Manivannan
Rapid and reversible switching between amorphous and crystalline phases of phase-change material promises to revolutionize the field of information processing with a wide range of applications including electronic, optoelectronics, and photonic memory devices. However, achieving faster crystallization is a key challenge. Here, we demonstrate femtosecond-driven transient inspection of ultrafast crystallization of as-deposited amorphous Ge1Sb2Te4 and Ge1Sb4Te7 thin films induced by a series of 120 fs laser pulses...
January 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29320394/neurological-respiratory-failure
#3
Mohan Rudrappa, Laxmi Kokatnur, Oleg Chernyshev
West Nile virus infection in humans is mostly asymptomatic. Less than 1% of neuro-invasive cases show a fatality rate of around 10%. Acute flaccid paralysis of respiratory muscles leading to respiratory failure is the most common cause of death. Although the peripheral nervous system can be involved, isolated phrenic nerve palsy leading to respiratory failure is rare and described in only two cases in the English literature. We present another case of neurological respiratory failure due to West Nile virus-induced phrenic nerve palsy...
January 10, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29319883/trait-specific-processes-of-convergence-and-conservatism-shape-ecomorphological-evolution-in-ground-dwelling-squirrels
#4
Bryan S McLean, Kristofer M Helgen, H Thomas Goodwin, Joseph A Cook
Our understanding of mechanisms operating over deep timescales to shape phenotypic diversity often hinges on linking variation in one or few trait(s) to specific evolutionary processes. When distinct processes are capable of similar phenotypic signatures, however, identifying these drivers is difficult. We explored ecomorphological evolution across a radiation of ground-dwelling squirrels whose history includes convergence and constraint, two processes that can yield similar signatures of standing phenotypic diversity...
January 10, 2018: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29319635/low-dose-epinephrine-boluses-for-acute-hypotension-in-the-picu
#5
Pamela D Reiter, Jennifer Roth, Beth Wathen, Jaime LaVelle, Leslie A Ridall
OBJECTIVES: To describe the use of low-dose bolus epinephrine in critically ill children during an acute hypotensive episode or prearrest condition. DESIGN: Institutional Review Board approved, single-center, retrospective medical chart review. SETTING: Large medical-surgical PICU within a freestanding, tertiary care children's hospital. PATIENTS: Patients admitted to the PICU between June 1, 2015, and June 1, 2016, who received low-dose (≤ 5 µg/kg) IV bolus epinephrine...
January 9, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29319010/audiometric-notch-and-extended-high-frequency-hearing-threshold-shift-in-relation-to-total-leisure-noise-exposure-an-exploratory-analysis
#6
Wenjia Wei, Stefanie Heinze, Doris G Gerstner, Sandra M Walser, Dorothee Twardella, Christina Reiter, Veronika Weilnhammer, Carmelo Perez-Alvarez, Thomas Steffens, Caroline E W Herr
BACKGROUND: Studies investigating leisure noise effect on extended high frequency hearing are insufficient and they have inconsistent results. The aim of this study was to investigate if extended high-frequency hearing threshold shift is related to audiometric notch, and if total leisure noise exposure is associated with extended high-frequency hearing threshold shift. MATERIALS AND METHODS: A questionnaire of the Ohrkan cohort study was used to collect information on demographics and leisure time activities...
November 2017: Noise & Health
https://www.readbyqxmd.com/read/29316722/quantitative-analysis-of-hepatitis-c-ns5a-viral-protein-dynamics-on-the-er-surface
#7
Markus M Knodel, Arne Nägel, Sebastian Reiter, Andreas Vogel, Paul Targett-Adams, John McLauchlan, Eva Herrmann, Gabriel Wittum
Exploring biophysical properties of virus-encoded components and their requirement for virus replication is an exciting new area of interdisciplinary virological research. To date, spatial resolution has only rarely been analyzed in computational/biophysical descriptions of virus replication dynamics. However, it is widely acknowledged that intracellular spatial dependence is a crucial component of virus life cycles. The hepatitis C virus-encoded NS5A protein is an endoplasmatic reticulum (ER)-anchored viral protein and an essential component of the virus replication machinery...
January 8, 2018: Viruses
https://www.readbyqxmd.com/read/29313618/for-h%C3%A3-yt-innhold-av-vitamin-d-i-kosttilskudd
#8
Lillian Reiter, Hanne Stenberg-Nilsen
No abstract text is available yet for this article.
December 21, 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/29313427/melatonin-therapy-for-blunt-trauma-and-strenuous-exercise-a-mechanism-involving-cytokines-nf%C3%AE%C2%BAb-akt-mafbx-and-murf-1
#9
Gerald J Maarman, Russel J Reiter
Muscle injury occurs due to trauma, strenuous exercise or sports activities; most people affected are athletes. Ineffectively treated muscle injury can negatively affect sports careers and quality of life after retirement from sports. Reports have indicated that the current therapeutic management of muscle injury, particularly anti-inflammatory drugs, are not necessarily effective. Therefore, better therapies are required. Accumulating evidence has demonstrated melatonin's potent antioxidant and anti-inflammatory actions against muscle pathology in sarcopenia or atrophy in systemic disease...
January 9, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29311675/sensorimotor-abilities-predict-on-field-performance-in-professional-baseball
#10
Kyle Burris, Kelly Vittetoe, Benjamin Ramger, Sunith Suresh, Surya T Tokdar, Jerome P Reiter, L Gregory Appelbaum
Baseball players must be able to see and react in an instant, yet it is hotly debated whether superior performance is associated with superior sensorimotor abilities. In this study, we compare sensorimotor abilities, measured through 8 psychomotor tasks comprising the Nike Sensory Station assessment battery, and game statistics in a sample of 252 professional baseball players to evaluate the links between sensorimotor skills and on-field performance. For this purpose, we develop a series of Bayesian hierarchical latent variable models enabling us to compare statistics across professional baseball leagues...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311635/subcellular-localization-of-mc4r-with-adcy3-at-neuronal-primary-cilia-underlies-a-common-pathway-for-genetic-predisposition-to-obesity
#11
Jacqueline E Siljee, Yi Wang, Adelaide A Bernard, Baran A Ersoy, Sumei Zhang, Aaron Marley, Mark Von Zastrow, Jeremy F Reiter, Christian Vaisse
Most monogenic cases of obesity in humans have been linked to mutations in genes encoding members of the leptin-melanocortin pathway. Specifically, mutations in MC4R, the melanocortin-4 receptor gene, account for 3-5% of all severe obesity cases in humans 1-3 . Recently, ADCY3 (adenylyl cyclase 3) gene mutations have been implicated in obesity 4,5 . ADCY3 localizes to the primary cilia of neurons 6 , organelles that function as hubs for select signaling pathways. Mutations that disrupt the functions of primary cilia cause ciliopathies, rare recessive pleiotropic diseases in which obesity is a cardinal manifestation 7 ...
January 8, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29303170/-ge2p2-2-a-binary-analogue-of-p4-as-a-precursor-to-the-ternary-cluster-anion-cd3-ge3p-3-3
#12
Stefan Mitzinger, Jascha Bandemehr, Kevin Reiter, J Scott McIndoe, Xiulan Xie, Florian Weigend, John F Corrigan, Stefanie Dehnen
The novel binary P4 analogue (Ge2P2)2- proved to be a suitable precursor for heteroatomic cluster synthesis. Over time in solution, it rearranges to form (Ge7P2)2-, as shown by NMR studies and X-ray diffraction. Reactions of (Ge2P2)2- with CdPh2 afford [K(crypt-222)]3[Cd3(Ge3P)3], containing an unprecedented ternary cluster anion with a triangular Cd3 moiety.
January 5, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29300972/a-recurrent-de-novo-missense-mutation-in-ubtf-causes-developmental-neuroregression
#13
Camilo Toro, Roderick T Hori, May Christine V Malicdan, Cynthia J Tifft, Amy Goldstein, William A Gahl, David R Adams, Fauni Harper, Lynne A Wolfe, Jianfeng Xiao, Mohammad M Khan, Jun Tian, Kevin A Hope, Lawrence T Reiter, Michel G Tremblay, Thomas Moss, Alexis L Franks, Chris Balak, Mark S LeDoux
UBTF (upstream binding transcription factor) exists as two isoforms; UBTF1 regulates rRNA transcription by RNA polymerase 1, whereas UBTF2 regulates mRNA transcription by RNA polymerase 2. Herein, we describe 4 patients with very similar patterns of neuroregression due to recurrent de novo mutations in UBTF (GRCh37/hg19, NC_000017.10:g.42290219C>T, NM_014233.3:c.628G>A) resulting in the same amino acid change in both UBTF1 and UBTF2 (p.Glu210Lys [p.E210K]). Disease onset in our cohort was at 2.5 to 3 yrs and characterized by slow progression of global motor, cognitive and behavioral dysfunction...
January 2, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29287025/2-hydroxyglutarate-detection-by-short-echo-time-magnetic-resonance-spectroscopy-in-routine-imaging-study-of-brain-glioma-at-3-0-t
#14
Girolamo Crisi, Silvano Filice, Maria Michiara, Pellegrino Crafa, Silvia Lana
OBJECTIVE: The objective of this study was to assess the effective performance of short echo time magnetic resonance spectroscopy (short TE MRS) for 2HG detection as biomarker of isocitrate dehydrogenase (IDH) status in all grade glioma (GL). METHODS: A total of 82 GL patients were prospectively investigated by short TEMRS at 3.0 T as part of a multimodal magnetic resonance imaging study protocol. Spectral analysis was performed using linear combination model. Tumor specimens were diagnosed as IDH mutant or wild type according to the 2016 World Health Organization (WHO) classification of brain tumors...
December 28, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29286409/the-ingestion-of-fluorescent-magnetic-nanoparticles-for-determining-fluid-uptake-abilities-in-insects
#15
Matthew S Lehnert, Kristen E Reiter, Andrew Bennett, Patrick D Gerard, Qi-Huo Wei, Miranda Byler, Huan Yan, Wah-Keat Lee
Fluid-feeding insects ingest a variety of liquids, which are present in the environment as pools, films, or confined to small pores. Studies of liquid acquisition require assessing mouthpart structure and function relationships; however, fluid uptake mechanisms are historically inferred from observations of structural architecture, sometimes unaccompanied with experimental evidence. Here, we report a novel method for assessing fluid-uptake abilities with butterflies (Lepidoptera) and flies (Diptera) using small amounts of liquids...
December 20, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29281056/phytomelatonin-a-universal-abiotic-stress-regulator
#16
Yanping Wang, Russel J Reiter, Zhulong Chan
Melatonin, a derivative of tryptophan, was detected in plant species in 1995. Melatonin has proven to be a diverse regulator during plant growth, development and stress responses. Recently, great progress has been made toward the detailed functions of melatonin in plant response to abiotic stress. Melatonin priming improved plant tolerance to cold, heat, salt and drought stresses through regulation of genes involved in DREB/CBF, HSF, SOS, and ABA pathways, respectively. As a free radicals scavenger, melatonin also directly detoxifies reactive oxygen species, thus alleviating membrane oxidation...
December 21, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29275919/melatonin-administration-lowers-biomarkers-of-oxidative-stress-and-cardio-metabolic-risk-in-type-2-diabetic-patients-with-coronary-heart-disease-a-randomized-double-blind-placebo-controlled-trial
#17
Fariba Raygan, Vahidreza Ostadmohammadi, Fereshteh Bahmani, Russel J Reiter, Zatollah Asemi
BACKGROUND & AIMS: Melatonin may benefit diabetic people with coronary heart disease (CHD) through its beneficial effects on biomarkers of oxidative stress and cardio-metabolic risk. This investigation evaluated the effects of melatonin administration on metabolic status in diabetic patients with CHD. METHODS: This randomized, double-blind, placebo-controlled trial was conducted and involved 60 diabetic patients with CHD. Subjects were randomly allocated into two groups to receive either 10 mg melatonin (2 melatonin capsules, 5 mg each) (n = 30) or placebo (n = 30) once a day for 12 weeks...
December 12, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29274042/sclerosing-epithelioid-fibrosarcoma-of-the-jaw-late-recurrence-from-a-low-grade-fibromyxoid-sarcoma
#18
Catherine Laliberte, Iona T Leong, Howard Holmes, Eric A Monteiro, Brian O'Sullivan, Brendan C Dickson
Sclerosing epithelioid fibrosarcoma (SEF) is an uncommon variant of fibrosarcoma that is characterized by a distinct morphology. It most frequently presents in the deep soft tissues of the lower extremities, often in intimate association with fascia and periosteum, although reports of the head and neck involvement have been reported. A minority of cases show morphological, immunohistochemical and molecular overlap with low grade fibromyxoid sarcoma (LG-FMS). Herein, we describe a case of a bland spindle cell neoplasm presenting in the jaw that was initially incompletely excised...
December 22, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29260297/highly-sensitive-and-specific-detection-of-giardia-duodenalis-entamoeba-histolytica-and-cryptosporidium-spp-in-human-stool-samples-by-the-bd-max%C3%A2-enteric-parasite-panel
#19
Marijo Parčina, Ingrid Reiter-Owona, Frank P Mockenhaupt, Valerija Vojvoda, Jean Bosco Gahutu, Achim Hoerauf, Ralf Ignatius
Detection of intestinal protozoan parasites by light microscopy is cumbersome, needs experienced personnel, and may lack sensitivity and/or specificity as compared with molecular-based stool assays. Here, we evaluated the BD MAX™ Enteric Parasite Panel, i.e., a multiplex real-time PCR assay for simultaneous detection of Giardia duodenalis, Entamoeba histolytica, and cryptosporidia (Cryptosporidium parvum and C. hominis), by examining 200 positive human stool samples (138 × G. duodenalis, 27 × E. histolytica, 35 × Cryptosporidium spp...
December 19, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29258626/the-past-as-a-work-in-progress
#20
Patricia Fara
Originating as a presidential address during the seventieth birthday celebrations of the British Society for the History of Science, this essay reiterates the society's long-standing commitment to academic autonomy and international cooperation. Drawing examples from my own research into female scientists and doctors during the First World War, I explore how narratives written by historians are related to their own lives, both past and present. In particular, I consider the influences on me of my childhood reading, my experiences as a physics graduate who deliberately left the world of science, and my involvement in programmes to improve the position of women in science...
December 20, 2017: British Journal for the History of Science
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