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JOURNAL ARTICLE
Jacqui S Scott, Anna Li, Hannah R Wardill
PURPOSE OF REVIEW: Disruption of the precious ecosystem of micro-organisms that reside in the gut - the gut microbiota - is rapidly emerging as a key driver of adverse side effects/toxicities caused by numerous anti-cancer agents. Although the contribution of the gut microbiota to these toxicities is understood with ever increasing precision, the cause of microbial disruption (dysbiosis) remains poorly understood. Here, we discuss current evidence on the cause(s) of dysbiosis after cancer therapy, positioning breakdown of the intestinal mucosa (mucositis) as a central cause...
April 23, 2024: Current Opinion in Supportive and Palliative Care
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JOURNAL ARTICLE
Marek Niedoszytko, Aleksandra Gorska, Knut Brockow, Patrizia Bonadonna, Magdalena Lange, Hanneke Kluin-Nelemans, Hanneke Oude-Elberink, Vito Sabato, Khalid Shoumariyeh, Dagmar von Bubnoff, Sabine Müller, Anja Illerhaus, Michael Doubek, Irena Angelova-Fischer, Olivier Hermine, Michel Arock, Chiara Elena, Luca Malcovati, Akif Selim Yavuz, Tanja Daniela Schug, Anna Belloni Fortina, Várkonyi Judit, Jason Gotlib, Jens Panse, Vladan Vucinic, Andreas Reiter, Juliana Schwaab, Massimo Triggiani, Mattias Mattsson, Christine Breynaert, Jan Romantowski, Roberta Zanotti, Elisa Olivieri, Alexander Zink, Annick van de Ven, Alex Stefan, Stephane Barete, Francesca Caroppo, Cecelia Perkins, Vanessa Kennedy, Deborah Christen, Mohamad Jawhar, Johannes Luebke, Roberta Parente, Kerstin Levedahl, Emir Hadzijusufovic, Karin Hartmann, Boguslaw Nedoszytko, Wolfgang R Sperr, Peter Valent
BACKGROUND: Hypersensitivity reactions (HR) are common in mastocytosis. However, little is known about triggers and risk factors. The registry of the European Competence Network on Mastocytosis (ECNM) enables reliable studies in a larger cohort of mastocytosis patients. We assessed prevalence, triggers and risk factors of HR in adults with mastocytosis in the ECNM registry. METHODS: Data were collected in 27 ECNM centers. We analyzed potential triggers (Hymenoptera venoms, food, drug, inhalant and others) and risk factors at diagnosis and during follow-up...
April 23, 2024: Allergy
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JOURNAL ARTICLE
Golnaz Eslamian, Mahnaz Jamee, Tooba Momen, Pejman Rohani, Sarehossadat Ebrahimi, Mehrnaz Mesdaghi, Soodeh Ghadimi, Mahboubeh Mansouri, Seyed Alireza Mahdaviani, Mahnaz Sadeghi-Shabestari, Morteza Fallahpour, Bibi Shahin Shamsian, Narges Eslami, Samin Sharafian, Naghi Dara, Peiman Nasri, Niloufar Amini, Javad Enayat, Mazdak Fallahi, Leila Ghasemi Hashtrodi, Mohammad Shojaei, Martha Guevara Becerra, Holm H Uhlig, Zahra Chavoshzadeh
Patients with very early-onset inflammatory bowel disease (VEO-IBD) may present because of underlying monogenic inborn errors of immunity (IEI). Strong differences have been observed in the causes of monogenic IBD among ethnic populations. This multi-center study was carried out on 16 Iranian patients with VEO-IBD. We reviewed clinical and basic immunologic evaluation including flow cytometry and immunoglobulin levels. All patients underwent clinical whole exome sequencing (WES). Sixteen patients (8 females and 8 males) with a median age of 43...
April 23, 2024: Clinical and Experimental Immunology
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JOURNAL ARTICLE
Manuela Hoedl, Lea Reiter, Gerhilde Schuettengruber, Silvia Bauer, Daniela Schoberer
BACKGROUND: Research shows that front-line nurses' workload and stress levels increased during the coronavirus disease 2019 (COVID-19) pandemic, however, there is little research of these factors in relation to nurse managers. Previous research undertaken in Austria found that some nurse managers working in nursing homes undertook clinical as well as managerial functions during the pandemic, a double burden that could have increased their stress levels and have had adverse psychological, physical and social consequences...
April 23, 2024: Nursing Management (Harrow)
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JOURNAL ARTICLE
Pamela Filiatrault-Veilleux, Chantal Desmarais, Caroline Bouchard, Breanne Esau, Audette Sylvestre
PURPOSE: Using a longitudinal design, this study aimed to describe inferential comprehension abilities of neglected French-speaking preschool children from 42 to 66 months of age in comparison to non-neglected peers, to examine the association with receptive vocabulary, and to determine whether rates of change in inferential abilities over time was stable between the two group conditions. METHOD: An inferential comprehension task and the French version of the Peabody Picture Vocabulary Test-Fourth Edition were administered to a group of neglected children ( n = 37-40) and to a group of same-age non-neglected children ( n = 71-91) at 42, 54, and 66 months old, as part of the Early Longitudinal Language and Neglect study...
April 22, 2024: Journal of Speech, Language, and Hearing Research: JSLHR
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JOURNAL ARTICLE
Mukesh Karunanethy, Rahul Tripathi, Mahesh V Panchagnula, Raghunathan Rengaswamy
This work, in a pioneering approach, attempts to build a biometric system that works purely based on the fluid mechanics governing exhaled breath. We test the hypothesis that the structure of turbulence in exhaled human breath can be exploited to build biometric algorithms. This work relies on the idea that the extrathoracic airway is unique for every individual, making the exhaled breath a biomarker. Methods including classical multi-dimensional hypothesis testing approach and machine learning models are employed in building user authentication algorithms, namely user confirmation and user identification...
2024: PloS One
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JOURNAL ARTICLE
Jeffrey T Reiter
In this letter to the Collaborative Family Healthcare Association (CFHA) Board and Community, the author nominates Mountainview Consulting Group, specifically Patricia Robinson, PhD (Patti) and Kirk Strosahl, PhD, for the 2023 Don Bloch Award. When he thinks of the qualities Don Bloch is remembered for-Intellectual, Behavioral, and Relational qualities-there simply is no entity or person more qualified for this award than Patti and Kirk. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
March 2024: Families, Systems & Health: the Journal of Collaborative Family Healthcare
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JOURNAL ARTICLE
Ioanna Anastasopoulou, Douglas Owen Cheyne, Pascal van Lieshout, Blake Warren Johnson
INTRODUCTION: Articulography and functional neuroimaging are two major tools for studying the neurobiology of speech production. Until now, however, it has generally not been feasible to use both in the same experimental setup because of technical incompatibilities between the two methodologies. METHODS: Here we describe results from a novel articulography system dubbed Magneto-articulography for the Assessment of Speech Kinematics (MASK), which is technically compatible with magnetoencephalography (MEG) brain scanning systems...
2024: Frontiers in Human Neuroscience
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JOURNAL ARTICLE
Arindam Das, Gouranga Jana, Shukdeb Sing, Anirban Basu
Interaction under amyloidogenic condition between naturally occurring protoberberine alkaloid palmatine and hen egg white lysozyme was executed by adopting spectrofluorometric and theoretical molecular docking and dynamic simulation analysis. In spetrofluorometric method, different types of experiments were performed to explore the overall mode and mechanism of interaction. Intrinsic fluorescence quenching of lysozyme (Trp residues) by palmatine showed effective binding interaction and also yielded different binding parameters like binding constant, quenching constant and number of binding sites...
April 19, 2024: International Journal of Biological Macromolecules
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JOURNAL ARTICLE
Manisha Jhajhariya, Yash Mangla, Atika Chandra, Shailendra Goel, Rajesh Tandon
Evolutionary maintenance of dioecy is a complex phenomenon and varies by species and underlying pathways. Also, different sexes may exhibit variable resource allocation (RA) patterns among the vegetative and reproductive functions. Such differences are reflected in the extent of sexual dimorphism. Though rarely pursued, investigation on plant species harbouring intermediate sexual phenotypes may reveal useful information on the strategy pertaining to sex-ratios and evolutionary pathways. We studied H. rhamnoides ssp...
2024: PloS One
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JOURNAL ARTICLE
Klaas Sijtsma, Jules L Ellis, Denny Borsboom
The sum score on a psychological test is, and should continue to be, a tool central in psychometric practice. This position runs counter to several psychometricians' belief that the sum score represents a pre-scientific conception that must be abandoned from psychometrics in favor of latent variables. First, we reiterate that the sum score stochastically orders the latent variable in a wide variety of much-used item response models. In fact, item response theory provides a mathematically based justification for the ordinal use of the sum score...
April 17, 2024: Psychometrika
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JOURNAL ARTICLE
Edward M Schaeffer, Sandy Srinivas, Nabil Adra, Yi An, Rhonda Bitting, Brian Chapin, Heather H Cheng, Anthony Victor D'Amico, Neil Desai, Tanya Dorff, James A Eastham, Thomas A Farrington, Xin Gao, Shilpa Gupta, Thomas Guzzo, Joseph E Ippolito, R Jeffrey Karnes, Michael R Kuettel, Joshua M Lang, Tamara Lotan, Rana R McKay, Todd Morgan, Julio M Pow-Sang, Robert Reiter, Mack Roach, Tyler Robin, Stan Rosenfeld, Ahmad Shabsigh, Daniel Spratt, Russell Szmulewitz, Benjamin A Teply, Jonathan Tward, Richard Valicenti, Jessica Karen Wong, Jenna Snedeker, Deborah A Freedman-Cass
The NCCN Guidelines for Prostate Cancer include recommendations for staging and risk assessment after a prostate cancer diagnosis and for the care of patients with localized, regional, recurrent, and metastatic disease. These NCCN Guidelines Insights summarize the panel's discussions for the 2024 update to the guidelines with regard to initial risk stratification, initial management of very-low-risk disease, and the treatment of nonmetastatic recurrence.
April 2024: Journal of the National Comprehensive Cancer Network: JNCCN
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JOURNAL ARTICLE
Dawei Liu, Xin Tan, Huifen Yan, Wei Li
Skillful utilization of mental arithmetic can significantly improve students' mathematical computation ability. However, it was observed that primary school students often resort to reiterating the process of written arithmetic in their minds during mental arithmetic, which is not conducive to their numerical ability improvement. This paper devises a set of graphic teaching aids for primary school students' mental arithmetic improvement based on mental arithmetic strategies, schema theory, and working memory...
2024: PloS One
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JOURNAL ARTICLE
Daniela Agostinho David, Rafaela Pires, Maria João Fonseca, Miguel Xavier, Miguel Branco
OBJECTIVE: This study aimed to evaluate the disparity of the expectations and basic knowledge of prenatal ultrasound (US) screening among pregnant women and make a comparison with the current scientific knowledge and national recommendations. We hypothesize that sociodemographic factors, including age, education, and professional occupation, may be associated with different levels of knowledge. METHODS: This was a cross-sectional study performed in 2021 of 336 women aged 18 to 46 years in a maternity facility in a tertiary hospital in Portugal...
April 16, 2024: International Journal of Gynaecology and Obstetrics
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JOURNAL ARTICLE
Sana Aslam, Aqsa Z Awan, Madiha M Iqbal, Saira Saeed, Mariyam Saeed, Zartaj Liaqat, Saad Abdullah Dar, Salamat Ali, Muhammad Ahsan Asif, Haseeb Mehmood Qadri
Background and objective Alopecia areata (AA) is a reiterative and nonscarring type of hair loss that can affect any hairy area of the body, particularly the scalp. It manifests as patchy or confluent hair loss with variations in demographics and ethnicity. There are numerous treatment options available, including topical and systemic steroids, topical minoxidil, dithranol, tacrolimus, psoralen and ultraviolet therapy (PUVA), contact immunotherapy, and oral immunosuppressive drugs. However, no previous contrast for efficacy is present between the topical betamethasone versus topical minoxidil alone in our population...
March 2024: Curēus
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JOURNAL ARTICLE
Mina Obradovic, Florian Luf, Christian Reiterer, Sebastian Schoppmann, Andrea Kurz, Edith Fleischmann, Barbara Kabon
BACKGROUND: Pulmonary function is impaired after major abdominal surgery and might be less impaired by restrictive fluid administration. Under the assumption of a fluid-sparing effect of colloids, we tested the hypothesis that an intraoperative colloid-based goal-directed fluid management strategy impairs postoperative pulmonary function parameters less compared to goal-directed crystalloid administration. METHODS: We performed a preplanned, single-center substudy within a recently published trial evaluating the effect of goal-directed crystalloids versus colloids on a composite of major complications...
April 15, 2024: Perioperative Medicine
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JOURNAL ARTICLE
Camille Gauthier, Pauline Raynaud, Frédéric Jean-Alphonse, Amandine Vallet, Océane Vaugrente, Vinesh Jugnarain, Thomas Boulo, Christophe Gauthier, Eric Reiter, Gilles Bruneau, Pascale Crepieux
Luteinizing hormone (LH) is essential for reproduction, controlling ovulation and steroidogenesis. Its receptor (LHR) recruits various transducers leading to the activation of a complex signaling network. We recently identified iPRC1, the first variable fragment from heavy-chain-only antibody (VHH) interacting with intracellular loop 3 (ICL3) of the follicle-stimulating hormone receptor (FSHR). Because of the high sequence similarity of the human FSHR and LHR (LHCGR), here we examined the ability of the iPRC1 intra-VHH to modulate LHCGR activity...
April 13, 2024: Molecular and Cellular Endocrinology
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JOURNAL ARTICLE
Dathan M Byonanebye, Mark N Polizzotto, Fernando Maltez, Andri Rauch, Katharina Grabmeier-Pfistershammer, Ferdinand Wit, Stéphane De Wit, Antonella Castagna, Antonella d'Arminio Monforte, Cristina Mussini, Jan-Christian Wasmuth, Eric Fontas, Irene Abela, Mario Sarcletti, Loveleen Bansi-Matharu, Nadine Jaschinski, Lars Peters, Sean R Hosein, Vani Vannappagari, Cal Cohen, Emiliano Bissio, Amanda Mocroft, Matthew Law, Lene Ryom, Kathy Petoumenos
BACKGROUND: Integrase strand-transfer inhibitors (INSTIs) and tenofovir alafenamide have been associated with weight gain in several clinical trials and observational cohorts. However, whether weight gain associated with INSTIs and tenofovir alafenamide confers a higher risk of weight-related clinical events is unclear. We aimed to assess whether changes in BMI differentially increase hypertension or dyslipidaemia risk in people with HIV receiving INSTIs, tenofovir alafenamide, or both versus other contemporary regimens...
April 12, 2024: Lancet HIV
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JOURNAL ARTICLE
Ofer Reiter, Mor Miodovnik, Emily Avitan-Hersh, Nadav Astman, Nir Nathanson, Ayelet Rishpon, Aviv Barzilai, Alon Scope
INTRODUCTION: Early detection may lead to reduced morbidity and mortality from melanoma. This study aims to establish guidelines for selecting patients suitable for digital monitoring of skin lesions. METHODS: A literature review was conducted, followed by consensus among experts appointed by the Israeli Dermatology Association. RESULTS: Two effective methods for early melanoma diagnosis were identified: Total-body photography (TBP) and digital dermoscopy...
April 2024: Harefuah
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JOURNAL ARTICLE
Khalil El Gharib, Mangala Narasimhan
COVID-19 is still around, and in the most severe cases can rapidly progress to acute respiratory distress syndrome. When mechanical ventilation fails to improve oxygenation, we desperately shift our management to venovenous extracorporeal membrane oxygenation (vv-ECMO). In this opinion article, we discuss which patients are the most suitable to select for this technique, reiterate previous observations in acute respiratory distress syndrome, and the options for the patients judged not fitting for ECMO.
July 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
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