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https://www.readbyqxmd.com/read/28094228/health-promotion-in-practice-district-nurses-experiences-of-working-with-health-promotion-and-lifestyle-interventions-among-patients-at-risk-of-developing-cardiovascular-disease
#1
Kristina Lundberg, Miek C Jong, Lisbeth Kristiansen, Mats Jong
OBJECTIVE: Health Promotion Practice (HPP) has the objective to promote a healthier lifestyle and reduce the risk of disease. The aim of this study was to examine district nurses׳ experiences of working with health preventive actions among patients with risk factors for cardiovascular disease (CVD), and to identify facilitators and obstacles in HPP. DESIGN/SETTING: The study was carried out with a qualitative approach where individual semistructured interviews were performed with a total of 12 district nurses in primary care...
December 16, 2016: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/28088025/residues-of-2-hydroxy-3-phenylpyrazine-a-degradation-product-of-some-%C3%AE-lactam-antibiotics-in-environmental-water-in-vietnam
#2
Nguyen Van Sy, Kazuo Harada, Megumi Asayama, Minae Warisaya, Le Hong Dung, Yoshinori Sumimura, Khong Thi Diep, Le Viet Ha, Nguyen Nam Thang, Tran Thi Tuyet Hoa, Tran Minh Phu, Pham Ngoc Khai, Nguyen Thanh Phuong, Le Danh Tuyen, Yoshimasa Yamamoto, Kazumasa Hirata
Antibiotic-resistant bacteria have become a serious problem worldwide, caused in part by the excessive use and discharge of antibiotics into the environment. Ampicillin (ABPC) is a widely used antibiotic. However, this chemical rapidly decomposes in water containing divalent cations like Ca(2+) and Mg(2+), thus, detection of ABPC in environmental water is difficult. This study was carried out to evaluate the presence of 2-hydroxy-3-phenylpyrazine (HPP), one of the degradation products of ABPC and β-lactam antibiotics with an ABPC substructure, in environmental water...
January 2, 2017: Chemosphere
https://www.readbyqxmd.com/read/28072448/identification-of-altered-brain-metabolites-associated-with-tnap-activity-in-a-mouse-model-of-hypophosphatasia-using-untargeted-nmr-based-metabolomics-analysis
#3
Thomas Cruz, Marie Gleizes, Stéphane Balayssac, Etienne Mornet, Grégory Marsal, José Luis Millán, Myriam Malet-Martino, Lionel G Nowak, Véronique Gilard, Caroline Fonta
Tissue Nonspecific Alkaline Phosphatase (TNAP) is a key player of bone mineralization and TNAP gene (ALPL) mutations in human are responsible for hypophosphatasia (HPP), a rare heritable disease affecting the mineralization of bones and teeth. Moreover, TNAP is also expressed by brain cells and the severe forms of HPP are associated with neurological disorders, including epilepsy and brain morphological anomalies. However TNAP's role in the nervous system remains poorly understood. In order to investigate its neuronal functions, we aimed to identify without any a priori the metabolites regulated by TNAP in the nervous tissue...
January 10, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28071938/tailoring-structure-and-technological-properties-of-plant-proteins-using-high-hydrostatic-pressure
#4
Rui P Queirós, Jorge A Saraiva, José A Lopes da Silva
The demand for proteins is rising and alternatives to meat proteins are necessary since animal husbandry is expensive and intensive to the environment. Plant proteins appear as an alternative; however, their techno-functional properties need improvement. High-pressure processing (HPP) is a non-thermal technology that has several applications including the modification of proteins. The application of pressure allows modifying proteins' structure hence allowing to change several of their properties, such as hydration, hydrophobicity, and hydrophilicity...
January 10, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28040169/high-pressure-inactivation-of-brettanomyces-bruxellensis-in-red-wine
#5
Sanelle van Wyk, Filipa V M Silva
Brettanomyces bruxellensis ("Brett") is a major spoilage concern for the wine industry worldwide, leading to undesirable sensory properties. Sulphur dioxide, is currently the preferred method for wine preservation. However, due to its negative effects on consumers, the use of new alternative non-thermal technologies are increasingly being investigated. The aim of this study was to determine and model the effect of high pressure processing (HPP) conditions and yeast strain on the inactivation of "Brett" in Cabernet Sauvignon wine...
May 2017: Food Microbiology
https://www.readbyqxmd.com/read/28000043/molecular-defect-of-tissue-nonspecific-alkaline-phosphatase-bearing-a-substitution-at-position-426-associated-with-hypophosphatasia
#6
Hiba A Al-Shawafi, Keiichi Komaru, Kimimitsu Oda
Mutations in the ALPL gene encoding tissue-nonspecific alkaline phosphatase (TNSALP) cause hypophosphatasia (HPP), a genetic disorder characterized by deficiency of serum ALP and hypomineralization of bone and teeth. Three missense mutations for glycine 426 (by standard nomenclature) of TNSALP have been reported: cysteine (p.G426C), serine (p.G426S), and aspartate (p.G426D). We expressed TNSALP mutants carrying each missense mutation in mammalian cells. All three TNSALP mutants appeared on the cell surface like the wild-type (WT) TNSALP, although the cells expressing each TNSALP mutant exhibited markedly reduced ALP activity...
December 20, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27998428/-mutation-analysis-for-two-hypophosphatasia-families-with-targeted-next-generation-sequencing
#7
Y Bai, N Liu, J Yang, Y Guo, X D Kong
Objective: To detect the mutations in alkaline phosphatase (ALPL) gene of two Chinese families with perinatal hypophosphatasia (HPP), in order to explore the mechanism of this condition. Methods: Next-generation sequencing (NGS) of osteology system panel was carried out for exome sequencing in the mothers of 2 HPP fetuses, who visited Prenatal Diagnosis Center of the First Affiliated Hospital of Zhengzhou University. Further polymerase chain reaction (PCR) and Sanger sequencing validation was performed in the parents, affected fetuses and 200 unrelated healthy individuals to verify the mutation sites...
December 13, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27979173/effects-of-high-hydrostatic-pressure-ultraviolet-light-c-and-far-infrared-treatments-on-the-digestibility-antioxidant-and-antihypertensive-activity-of-%C3%AE-casein
#8
Guanlan Hu, Yuanrong Zheng, Zhenmin Liu, Yang Xiao, Yun Deng, Yanyun Zhao
Alpha-casein is the most important bioactive protein in processing technologies. This study investigated the digestibility, antioxidant and antihypertensive activities of α-casein when treated by high hydrostatic pressure (HPP), ultraviolet light-C (UV-C), and far-infrared radiation (FIR). The in vitro digestibility was modified after treatments, especially after 5min/200MPa HHP treatment. Ultra-performance liquid chromatography-tandem mass spectrometry analysis showed that one 5min/200MPa HHP treatment resulted in the highest yield of peptides...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27977135/characterization-of-two-late-stage-enzymes-involved-in-fosfomycin-biosynthesis-in-pseudomonads
#9
Philip Olivares, Emily C Ulrich, Jonathan R Chekan, Wilfred A van der Donk, Satish K Nair
The broad-spectrum phosphonate antibiotic fosfomycin is currently in use for clinical treatment of infections caused by both Gram-positive and Gram-negative uropathogens. The antibiotic is biosynthesized by various streptomycetes, as well as by pseudomonads. Notably, the biosynthetic strategies used by the two genera share only two steps: the first step in which primary metabolite phosphoenolpyruvate (PEP) is converted to phosphonopyruvate (PnPy) and the terminal step in which 2-hydroxypropylphosphonate (2-HPP) is converted to fosfomycin...
December 27, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/27958538/perfect-vortex-in-three-dimensional-multifocal-array
#10
Duo Deng, Yan Li, Yanhua Han, Xiaoya Su, Jingfu Ye, Jianmin Gao, Qiaoqun Sun, Shiliang Qu
We proposed an approach for creating three-dimensional (3D) multifocal perfect vortices arrays by using a high numerical aperture objective. The position, orbital angular momentum states, number and diameter of the perfect vortices can be freely modulated by a special designed hybrid phase plate (HPP). HPP could be calculated by 3D phase shifting expression which is derived from Fourier transform theory of the Debye diffraction integral. Furthermore, we developed a novel pixel checkerboard method for adding phase information into the HPP...
December 12, 2016: Optics Express
https://www.readbyqxmd.com/read/27938859/cyanogenic-pseudomonas-spp-strains-are-concentrated-in-the-rhizosphere-of-alpine-pioneer-plants
#11
Tomaž Rijavec, Aleš Lapanje
HCN producing bacteria have previously been isolated from alpine mineral soil and their ecophysiology was presumed to be associated with mineral weathering. Nevertheless, the high ecological patchiness of the alpine environment calls for an extensive and detailed analysis of the spatial distribution of HCN producing bacterial populations and their associated weathering traits. Our results of such an analysis showed that primarily the rhizosphere of pioneer plants was rich in HPPs, harbouring the most potent HCN producers...
January 2017: Microbiological Research
https://www.readbyqxmd.com/read/27919850/detection-and-differentiation-of-early-hepatocellular-carcinoma-from-cirrhosis-using-ct-perfusion-in-a-rat-liver-model
#12
Jin-Ping Li, Guang-Long Feng, Da-Qing Li, Hai-Bo Wang, De-Li Zhao, Yong Wan, Hui-Jie Jiang
BACKGROUND: Functional imaging such as CT perfusion can detect morphological and hemodynamic changes in hepatocellular carcinoma (HCC). Pre-carcinoma and early HCC nodules are difficult to differentiate by observing only their hemodynamics changes. The present study aimed to investigate hemodynamic parameters and evaluate their differential diagnostic cut-off between pre-carcinoma and early HCC nodules using CT perfusion and receiver operating characteristic (ROC) curves. METHODS: Male Wistar rats were randomly divided into control (n=20) and experimental (n=70) groups...
December 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/27893237/emergence-of-japanese-infants-prosodic-preferences-in-infant-directed-vocabulary
#13
Akiko Hayashi, Reiko Mazuka
The article examines the role of infant-directed vocabulary (IDV) in infants language acquisition, specifically addressing the question of whether IDV forms that are not prominent in adult language may nonetheless be useful to the process of acquisition. Japanese IDV offers a good test case, as IDV characteristically takes a bisyllabic H(eavy)-L(ight) form that is rare in adult speech. In 5 experiments using the Headturn Preference Procedure (HPP), 8- to 10-month-old Japanese infants, but not 4- to 6-month-olds, were found to show a preference for bisyllabic H-L words over other types of words...
January 2017: Developmental Psychology
https://www.readbyqxmd.com/read/27885688/effect-of-high-pressure-processing-and-thermal-pasteurization-on-overall-quality-parameters-of-white-grape-juice
#14
Yin-Hsuan Chang, Sz-Jie Wu, Bang-Yuan Chen, Hsiao-Wen Huang, Chung-Yi Wang
BACKGROUND: The aim of this study was to investigate the microbial levels, physicochemical and antioxidant properties, and polyphenoloxidase (PPO) and peroxidase (POD) activity, as well as to conduct a sensory analysis of white grape juice treated with high pressure processing (HPP) and thermal pasteurization (TP) over a period of 20 days of refrigerated storage. RESULTS: Results showed that HPP treatment of 600 MPa and TP significantly reduced aerobic bacteria, coliforms, and yeast counts...
November 24, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27885680/effect-of-high-hydrostatic-pressure-on-the-enzymatic-hydrolysis-of-bovine-serum-albumin
#15
Serena De Maria, Giovanna Ferrari, Paola Maresca
BACKGROUND: The extent of the enzymatic proteolysis mainly depends on the accessibility of the peptide bonds, which stabilize the protein structure. High Hydrostatic Pressure (HHP) process is able to induce, at certain operating conditions, protein displacement, thus suggesting that this technology can be used to modify protein resistance to the enzymatic attack. This work aims at investigating the mechanism of the enzymatic hydrolysis assisted by HHP performed at different processing conditions (pressure level, treatment time)...
November 24, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27847653/nondestructive-microcomputed-tomography-evaluation-of-mineral-density-in-exfoliated-teeth-with-hypophosphatasia
#16
Sachiko Hayashi-Sakai, Takafumi Hayashi, Makoto Sakamoto, Jun Sakai, Junko Shimomura-Kuroki, Hideyoshi Nishiyama, Kouji Katsura, Makiko Ike, Yutaka Nikkuni, Miwa Nakayama, Marie Soga, Taichi Kobayashi
Most cases of hypophosphatasia (HPP) exhibit early loss of primary teeth. Results of microcomputed tomography (micro-CT) analysis of teeth with HPP have rarely been reported. The purpose of the present study was to describe the mineral density distribution and mapping of exfoliated teeth from an HPP patient using micro-CT. Four exfoliated teeth were obtained from a patient with HPP. Enamel and dentin mineral densities of exfoliated teeth were measured on micro-CT. The mean values of enamel and dentin mineral densities in mandibular primary central incisors with HPP were 1...
2016: Case Reports in Dentistry
https://www.readbyqxmd.com/read/27835773/microbiota-of-high-pressure-processed-serrano-ham-investigated-by-culture-dependent-and-culture-independent-methods
#17
N Martínez-Onandi, A Castioni, E San Martín, A Rivas-Cañedo, M Nuñez, S Torriani, A Picon
The microbiota of Serrano dry-cured ham of different chemical composition, subjected or not to high-pressure processing (HPP), was investigated using culture-dependent and culture-independent methods. Microbial counts were submitted to analysis of variance with physicochemical parameters (aw, NaCl concentration, salt-in-lean ratio and intramuscular fat content) or HPP as main effects. In untreated hams, physicochemical parameters significantly affected counts of aerobic mesophiles, psychrotrophs, and moulds and yeasts...
January 16, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27805893/hypophosphatasia-evaluation-of-size-and-mineral-density-of-exfoliated-teeth
#18
S Hayashi-Sakai, N Numa-Kinjoh, M Sakamoto, J Sakai, J Matsuyama, T Mitomi, T Sano-Asahito, S Kinoshita-Kawano
OBJECTIVE: Most cases of hypophosphatasia (HPP) exhibit early loss of primary teeth. Results of micro-computed tomography (micro-CT) analysis of teeth with HPP have not yet been reported. The purpose of the present study was to describe the size and mineral density distribution and mapping of exfoliated teeth with HPP using micro CT. STUDY DESIGN: Seven exfoliated teeth were obtained from a patient with HPP. Exfoliated teeth sizes were measured on micro CT images and mineral densities of the mandibular primary central incisors were determined...
2016: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/27801695/early-response-of-hepatocellular-carcinoma-to-chemoembolization-volume-computed-tomography-liver-perfusion-imaging-as-a-short-term-response-predictor
#19
Tian-Hao Su, Wen He, Long Jin, Guang Chen, Guo-Wen Xiao
OBJECTIVE: The aim of this study was to investigate the efficacy of lesion-oriented whole-liver computed tomography (CT) perfusion for predicting transarterial chemoembolization early treatment response in patients with hepatocellular carcinoma (HCC). METHODS: Volume helical shuttle CT perfusion imaging on the whole liver was prospectively performed on 39 patients with 46 independent HCC lesions before target-selected chemoembolization. The therapeutic effects were assessed: responder group included lesions with a complete and partial response, whereas the nonresponder group contained stable and progressive disease...
October 31, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27796472/-hypophosphatasia-what-is-currently-available-for-treatment
#20
T Schmidt, M Amling, F Barvencik
This review presents the current knowledge on the diagnosis and treatment of hypophosphatasia, a rare genetic disease, caused by mutations in the tissue non-specific alkaline phosphatase (TNSALP) gene. The clinical spectrum of hypophosphatasia is highly variable ranging from lethal infantile forms to mild forms diagnosed in adults. Although the disease rarely occurs, correct diagnosis is important to provide appropriate treatment and to avoid worsening by use of harmful drugs such as bisphosphonates. Low serum values of alkaline phosphatase (ALP) is the main feature of HPP, but by itself not sufficient for diagnosis, as it can occur under different conditions...
December 2016: Der Internist
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