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https://www.readbyqxmd.com/read/29325131/crystal-structures-of-high-pressure-phases-formed-in-si-by-laser-irradiation
#1
Hiroyuki Iwata, Daisuke Kawaguchi, Hiroyasu Saka
Internal modification induced in Si by a permeable pulse laser was investigated by transmission electron microscopy. A laser induced modified volume (LIMV) was a cylindrical rod along the track of a laser beam with the head at the focus of the laser beam. In the LIMV, beside voids, dislocations, micro-cracks and what had been supposed to be an unidentified high-pressure phase (hpp) of Si were observed in LIMV. The so-called 'hpp' was identified mostly as diamond Si.
January 6, 2018: Microscopy
https://www.readbyqxmd.com/read/29297597/validation-of-a-novel-scoring-system-for-changes-in-skeletal-manifestations-of-hypophosphatasia-in-newborns-infants-and-children-the-radiographic-global-impression-of-change-scale
#2
Michael P Whyte, Kenji P Fujita, Scott Moseley, David D Thompson, William H McAlister
Hypophosphatasia (HPP) is the heritable metabolic disease characterized by impaired skeletal mineralization due to low activity of the tissue-nonspecific isoenzyme of alkaline phosphatase. Although HPP during growth often manifests with distinctive radiographic skeletal features, no validated method was available to quantify them, including changes over time. We created the Radiographic Global Impression of Change (RGI-C) scale to assess changes in the skeletal burden of pediatric HPP. Site-specific pairs of radiographs of newborns, infants, and children with HPP from 3 clinical studies of asfotase alfa, an enzyme replacement therapy for HPP, were obtained at Baseline and during treatment...
January 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29291275/it-takes-a-village-first-reflections-from-hpp-s-new-editor-in-chief
#3
Kathleen M Roe
No abstract text is available yet for this article.
January 2018: Health Promotion Practice
https://www.readbyqxmd.com/read/29282898/a-perspective-on-proteomics-of-infectious-diseases
#4
Apoorva Venkatesh, Concha Gil, Manuel Fuentes, Joshua LaBaer, Sanjeeva Srivastava
Pneumonia, HIV/AIDS, tuberculosis, malaria and several other diseases caused by pathogens largely contribute to the enormous burden of infectious diseases. Over the last few decades, the impact of infectious diseases on a population has been drastic and remains a major health concern even today. Despite advances in science and technology in this era of health and development, there is a substantial knowledge gap in our understanding of the molecular basis of these infectious diseases. The availability of valuable genomic information for a number of pathogens and their hosts has improved our understanding of disease pathogenesis but has not always been useful in addressing important biological questions...
December 28, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29236161/genetic-analysis-of-adults-heterozygous-for-alpl-mutations
#5
Agnès Taillandier, Christelle Domingues, Annika Dufour, Françoise Debiais, Pascal Guggenbuhl, Christian Roux, Catherine Cormier, Bernard Cortet, Valérie Porquet-Bordes, Fabienne Coury, David Geneviève, Jean Chiesa, Thierry Colin, Elaine Fletcher, Agnès Guichet, Rose-Marie Javier, Michel Laroche, Michael Laurent, Ekkehart Lausch, Bruno LeHeup, Cédric Lukas, Georg Schwabe, Ineke van der Burgt, Christine Muti, Brigitte Simon-Bouy, Etienne Mornet
Hypophosphatasia (HPP) is a rare inherited metabolic bone disease due to a deficiency of the tissue nonspecific alkaline phosphatase isoenzyme (TNSALP) encoded by the ALPL gene. Patients have consistently low serum alkaline phosphatase (AP), so that this parameter is a good hallmark of the disease. Adult HPP is heterogeneous, and some patients present only mild nonpathognomonic symptoms which are also common in the general population such as joint pain, osteomalacia and osteopenia, chondrocalcinosis, arthropathy and musculoskeletal pain...
December 13, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29219297/expanding-the-chemistry-of-rhenium-metal-metal-bonded-fluoro-complexes-facile-preparation-and-characterization-of-paddlewheel-complexes
#6
Samundeeswari Mariappan Balasekaran, Alfred P Sattelberger, Adelheid Hagenbach, Frederic Poineau
Quadruply bonded rhenium(III) dimers with the stoichiometry Re2L4F2 (1, L = hexahydro-2H-pyrimido[1,2a]pyrimidinate (hpp-); 2, L = diphenyl formamidinate (dpf-)) were prepared from the solid-state melt reactions (SSMRs) between (NH4)2[Re2F8]·2H2O and HL. Those compounds were characterized in the solid state by single-crystal X-ray diffraction and in solution by UV-visible spectroscopy and cyclic voltammetry. The compound [Re2(hpp)4F2]PF6 (3) was prepared from the one-electron oxidation of Re2(hpp)4F2 with [Cp2Fe]PF6...
December 8, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29210831/correlates-of-linkage-to-hiv-pre-exposure-prophylaxis-prep-among-hiv-testing-clients
#7
Charlene A Flash, Oluwatobi O Adegboyega, Xiaoying Yu, Carmen Avalos, Syundai Johnson, Kenneth H Mayer, Thomas P Giordano
BACKGROUND: Publicly funded HIV testing sites can identify HIV pre-exposure prophylaxis (PrEP) candidates and provide PrEP linkage. SETTING: Harris Health System's HIV clinic, HIV testing program and HIV Prevention Program in Houston, TX, a high HIV incidence city. METHODS: A prospective assessment of individuals ≥18 years old recruited from walk-in HIV testing December, 2013 to April, 2015 included risk assessment, HIV testing and self-administered survey, with follow-up surveys at 6 and 12 months and medical record review...
November 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29191025/progress-and-future-direction-of-chromosome-centric-human-proteome-project
#8
Young-Ki Paik, Christopher M Overall, Eric W Deutsch, Jennifer E Van Eyk, Gilbert S Omenn
This special issue of JPR celebrates the fifth anniversary of the Chromosome-Centric Human Proteome Project (C-HPP). We present 27 manuscripts in four categories: (i) Metrics of Progress and Resources, (ii) Missing Protein Detection and Validation, (iii) Analytical Methods and Quality Assessment, and (iv) Protein Functions and Disease. We briefly introduce key messages from each paper, mostly from C-HPP teams and some from the Biology and Disease-driven HPP. From the first few months of the C-HPP NeXt-MP50 Missing Proteins Challenge, authors report 73 missing protein detections that meet the HPP guidelines using several novel approaches...
December 1, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29185824/comparison-between-high-pressure-processing-and-chemical-extraction-astaxanthin-yield-from-six-species-of-shrimp-carapace
#9
Cicy Irna, Irwandi Jaswir, Rashidi Othman, Dzun Noraini Jimat
Astaxanthin is one of the main carotenoid pigments. It has beneficial effects on the immune system of the human body due to its powerful antioxidant properties. The application of this bioactive compound can be found to be significant in the food, pharmaceutical, and cosmetics industries. The aim of this research was to investigate astaxanthin yield from six species of Malaysian shrimp carapace. Six types of shrimp species-Parapenaeopsis sculptili, Metapenaeus lysianassa, Macrobrachium rosenbergii, Metapenaeopsis hardwickii, Penaeus merguiensis, and Penaeus monodon-were used to investigate total carotenoid content and astaxanthin yield...
November 29, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29173640/effect-of-high-pressure-processing-on-the-survival-of-salmonella-enteritidis-and-shelf-life-of-chicken-fillets
#10
Anthoula A Argyri, Olga S Papadopoulou, Aspasia Nisiotou, Chrysoula C Tassou, Nikos Chorianopoulos
High pressure processing (HPP) is a preservation technology alternative to heat treatment that is mild for food, but effectively inactivates the spoilage microbiota and foodborne pathogens of several foods. The purpose of the current study was to evaluate the effect of HPP on Salmonella ser. Enteritidis, indigenous microbiota and shelf-life of chicken fillets. Chicken fillets were inoculated with S. Enteritidis at three different initial inocula (3, 5, 7 log CFU/g), packed under vacuum, treated or not with HPP (500 MPa/10 min) and stored at 4 and 12 °C...
April 2018: Food Microbiology
https://www.readbyqxmd.com/read/29160033/discordant-fetal-phenotype-of-hypophosphatasia-in-two-siblings
#11
Satoru Ikenoue, Kei Miyakoshi, Tomohiro Ishii, Yu Sato, Toshimitsu Otani, Yohei Akiba, Yoshifumi Kasuga, Daigo Ochiai, Tadashi Matsumoto, Yosuke Ichihashi, Yohei Matsuzaki, Kanako Tachikawa, Toshimi Michigami, Gen Nishimura, Kazushige Ikeda, Tomonobu Hasegawa, Mamoru Tanaka
Hypophosphatasia (HPP) is an autosomal recessive metabolic disorder with impaired bone mineralization due to mutations in the ALPL gene. The genotype-phenotype correlation of this disorder has been widely described. Here, we present two affected siblings, whose fetal phenotypes were discordant. A 31-year-old Japanese woman, G0P0, was referred to our institution because of fetal micromelia. After obstetric counseling, the pregnancy was terminated at 21 weeks' gestation. Post-mortem radiographs demonstrated severely defective mineralization of the skeleton...
November 21, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29159075/enzyme-replacement-therapy-in-perinatal-hypophosphatasia-case-report-of-a-negative-outcome-and-lessons-for-clinical-practice
#12
Gregory Costain, Aideen M Moore, Lauren Munroe, Alison Williams, Randi Zlotnik Shaul, Cheryl Rockman-Greenberg, Martin Offringa, Peter Kannu
Enzyme replacement therapy (ERT) is a newly approved disease-modifying treatment for hypophosphatasia (HPP), a rare metabolic bone disorder. With an orphan drug and ultra-rare disease, sharing information about responders and non-responders is particularly important, as any one centre's familiarity with its use will be limited. Nearly all published data in infants and very young children with life-threatening HPP are from three small clinical trials that have reported generally positive outcomes. We describe in detail a patient with perinatal HPP for whom treatment with ERT was not successful...
March 2018: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/29154478/on-the-dual-reactivity-of-a-nucleophilic-dihydrido-diborane-reaction-at-the-b-b-bond-and-or-the-b-h-bond
#13
Anna Widera, Elisabeth Kaifer, Hubert Wadepohl, Hans-Jörg Himmel
The electron-rich, double-base stabilized dihydrido-diborane(4) [HB(hpp)]2 (hpp = 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidinate) combines two different, easily accessible reactive sites: the B-B and B-H bond. We hereby report two basically similar reactions of [HB(hpp)]2 with catecholborane and B-chlorocatecholborane unsuspectedly resulting in two different reactivities. While reaction of the diborane with two equivalents of HB(cat) proceeded under formation of a cationic triborane with a (3c2e) bond, [{HB(μ-hpp)}2(μ-BH2)]+, reaction with ClB(cat) led to hydride-chloride substitution yielding [ClB(hpp)]2...
November 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29146345/effect-of-high-pressure-processing-on-colour-phytochemical-contents-and-antioxidant-activities-of-purple-waxy-corn-zea-mays-l-var-ceratina-kernels
#14
Kawinchaya Saikaew, Kamol Lertrat, Mutita Meenune, Ratchada Tangwongchai
High-pressure processing (HPP) at 250-700 MPa for 30-45 min affects the colour parameters, phytochemical contents and antioxidant activities of purple waxy corn kernels (p < 0.05). The higher pressure-level, the lower L(∗), a(∗), b(∗), C(∗) and h(o) (p < 0.05). However, pressure-treated kernels at 700 MPa showed a similar colour profile to steam-treated kernels. HPP caused a loss in the total phenolic, flavonoid, and anthocyanin contents and antioxidant activities. The pressure-treated kernels had a higher phytochemical content than the steam-treated kernels...
March 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29083492/influence-of-high-pressure-processing-at-low-temperature-and-nisin-on-listeria-innocua-survival-and-sensory-preference-of-dry-cured-cold-smoked-salmon
#15
Noelle K Lebow, Lisa D DesRocher, Frank L Younce, Mei-Jun Zhu, Carolyn F Ross, Denise M Smith
Cold-smoked salmon (CSS) production lacks a validated kill step for Listeria monocytogenes. Although Listeria spp. are reduced by nisin or high-pressure processing (HPP), CSS muscle discoloration is often observed after HPP. Effects of nisin and low-temperature HPP on L. innocua survival (nonpathogenic surrogate for L. monocytogenes), spoilage organism growth, color, and sensory preference and peelability of CSS were studied. Cold-smoked sockeye salmon (Oncorhynchus nerka) fillets ± nisin (10 μg/g) were inoculated with a 3-strain L...
October 30, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29062791/the-challenge-of-human-spermatozoa-proteome-a-systematic-review
#16
REVIEW
Kambiz Gilany, Arash Minai-Tehrani, Mehdi Amini, Niloofar Agharezaee, Babak Arjmand
Currently, there are 20,197 human protein-coding genes in the most expertly curated database (UniProtKB/Swiss-Pro). Big efforts have been made by the international consortium, the Chromosome-Centric Human Proteome Project (C-HPP) and independent researchers, to map human proteome. In brief, anno 2017 the human proteome was outlined. The male factor contributes to 50% of infertility in couples. However, there are limited human spermatozoa proteomic studies. Firstly, the development of the mapping of the human spermatozoa was analyzed...
July 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/29059309/elevated-intraocular-pressure-induces-amyloid-%C3%AE-deposition-and-tauopathy-in-the-lateral-geniculate-nucleus-in-a-monkey-model-of-glaucoma
#17
Zhichao Yan, Huanquan Liao, Hongrui Chen, Shuifeng Deng, Yu Jia, Caibin Deng, Jianxian Lin, Jian Ge, Yehong Zhuo
Purpose: Recent evidence has suggested a potential association between Alzheimer's disease (AD) and glaucoma and found significant deposition of amyloid-β (Aβ) and Tau protein in the retinas of glaucoma patients. However, no coherent finding has emerged regarding the AD-like changes in the central visual system (CVS). Studies confirming the presence of Aβ and Tau neuropathology are warranted to identify the underlying mechanism that contributes to the visual impairment observed in glaucoma...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29051647/high-pressure-processing-and-post-high-pressure-storage-induce-the-change-of-polyglutamyl-folate-and-total-folate-from-different-legumes
#18
Shuangyan Luo, Hanying Duan, Yuchen Zou, Chao Wang
The aim of this work was to study the effect of high pressure processing (HPP) and post-HPP cold storage on the distribution of polyglutamyl and monoglutamyl folate and the absolute concentration of total folate in green beans, yardlong beans and winged beans using a validated ultra-high performance liquid chromatography-tandem mass spectrometry method. The results showed that HPP led to the deglutamylation of polyglutamyl folate to monoglutamyl folate in all of the investigated beans. The degree of deglutamylation was increased with enhancing processing pressure and extending holding time...
October 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29046930/asfotase-alfa-treatment-for-1%C3%A2-year-in-a-16%C3%A2-year-old-male-with-severe-childhood-hypophosphatasia
#19
S A Bowden, B H Adler
We describe the clinical outcome of asfotase alfa therapy in a 16-year-old boy with severe childhood hypophosphatasia (HPP), who began therapy at age 15 years. The patient was diagnosed with HPP at age 2 years when he presented with genu varum and premature loss of primary teeth. He had a history of multiple fractures requiring 16 orthopedic surgeries with rod and pin placement in his lower extremities. He had chronic skeletal pain and used cane to ambulate with great difficulty. His height Z score at age 15 years was - 5...
October 18, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29039980/advances-in-the-chromosome-centric-human-proteome-project-looking-to-the-future
#20
Young-Ki Paik, Gilbert S Omenn, William S Hancock, Lydie Lane, Christopher M Overall
The mission of the Chromosome-Centric Human Proteome Project (C-HPP), is to map and annotate the entire predicted human protein set (~20,000 proteins) encoded by each chromosome. The initial steps of the project are focused on 'missing proteins (MPs)', which lacked documented evidence for existence at protein level. In addition to remaining 2,579 MPs, we also target those annotated proteins having unknown functions, uPE1 proteins, alternative splice isoforms and post-translational modifications. We also consider how to investigate various protein functions involved in cis-regulatory phenomena, amplicons lncRNAs and smORFs...
November 10, 2017: Expert Review of Proteomics
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