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https://www.readbyqxmd.com/read/28088539/the-dna-damage-response-of-c-elegans-affected-by-gravity-sensing-and-radiosensitivity-during-the-shenzhou-8-spaceflight
#1
Ying Gao, Dan Xu, Lei Zhao, Yeqing Sun
Space radiation and microgravity are recognized as primary and inevitable risk factors for humans traveling in space, but the reports regarding their synergistic effects remain inconclusive and vary across studies due to differences in the environmental conditions and intrinsic biological sensitivity. Thus, we studied the synergistic effects on transcriptional changes in the global genome and DNA damage response (DDR) by using dys-1 mutant and ced-1 mutant of C. elegans, which respectively presented microgravity-insensitivity and radiosensitivity when exposure to spaceflight condition (SF) and space radiation (SR)...
January 7, 2017: Mutation Research
https://www.readbyqxmd.com/read/28081572/exposed-dentin-influence-of-cleaning-procedures-and-simulated-pulpal-pressure-on-bond-strength-of-a-universal-adhesive-system
#2
Simon Flury, Anne Peutzfeldt, Patrick R Schmidlin, Adrian Lussi
PURPOSE: To compare various pre-treatments serving as cleaning procedures of dentin on the bond strength of resin composite promoted by a universal adhesive system applied either in the absence or presence of simulated pulpal pressure. MATERIALS AND METHODS: Prior to application of the adhesive system (Scotchbond Universal) and resin composite (Filtek Z250), ground dentin surfaces were given one of five pre-treatments either without or with simulated pulpal pressure: 1) no pre-treatment, adhesive system in "self-etch" mode, 2) phosphoric acid etching, adhesive system in "total-etch" mode, 3) polishing with pumice on prophylaxis cup, 4) air abrasion with AIR-FLOW PLUS powder, 5) air abrasion with AIR-FLOW PERIO powder; n = 20/group of pre-treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28080924/selected-plasma-biochemistry-analytes-of-healthy-captive-sulcata-african-spurred-tortoises-centrochelys-sulcata
#3
David Eshar, Ady Y Gancz, Nili Avni-Magen, Effi Wagshal, Lisa M Pohlman, Mark A Mitchell
The sulcata or African spurred tortoise (Centrochelys sulcata) is a large tortoise species that is commonly kept in zoologic collections and as a pet. The objectives of this study were to establish reference intervals for selected biochemical analytes in clinically healthy captive sulcata tortoises and to evaluate the impact of blood sampling site and sex. Blood samples were collected from 60 tortoises from either the dorsal coccygeal (tail) vein or the subcarapacial venous plexus based on their body size. The packed cell volume and refractometric total solids (TS) were determined...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28079971/au-la2-ti2-o7-nanostructures-sensitized-with-black-phosphorous-for-plasmon-enhanced-photocatalytic-hydrogen-production-in-visible-and-near-infrared-light
#4
Mingshan Zhu, Xiaoyan Cai, Mamoru Fujitsuka, Junying Zhang, Tetsuro Majima
Efficient utilization of solar energy is a high-priority target and the search for suitable materials as photocatalysts that not only can harvest the broad wavelength of solar light, from UV to near-infrared (NIR) region, but also can achieve high and efficient solar-to-hydrogen conversion is one of the most challenging missions. Herein, using Au/La2 Ti2 O7 (BP-Au/LTO) sensitized with black phosphorus (BP), a broadband solar response photocatalyst was designed and used as efficient photocatalyst for H2 production...
January 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28079953/reversible-photoactivated-phosphorescence-of-gold-i-arylethynyl-complexes-in-aerated-dmso-solutions-and-gels
#5
Shigang Wan, Wei Lu
Phosphorescence in fluid solutions at ambient temperature is usually quenched by molecular oxygen via energy transfer, and singlet oxygen is concomitantly sensitized. The long-lived phosphorescence of a series of Au(I) arylethynyl complexes with tunable emission energies in aerated dimethyl sulfoxide (DMSO) solutions can be completely and repeatedly switched on by controlled photoirradiation. A trace amount of DMSO oxidation by the sensitized singlet oxygen is proposed to lead to a depletion of molecular oxygen in the local microenvironment of the Au(I) phosphor in the photoactivation processes...
January 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28078814/life-threatening-nutritional-deficiencies-in-a-dialysis-patient
#6
Fahad Aziz, Kunal Chaudhary
Nutritional deficiencies are very common among the patient on chronic hemodialysis. But they can be easily overlooked or misdiagnosed. Deficiencies of trace elements and phosphorous is rare among this patient population but if neglected can lead to catastrophic effects. We describe a case report of a patient with ESRD recently started on outpatient maintenance hemodialysis, who presented with life threatening muscular weakness with respiratory failure requiring prolonged mechanical ventilation. On initial workup, it was unclear what the cause of her weakness was, however, further investigations showed undetectable phosphorous levels as well as very low levels of trace elements...
January 11, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28076932/aortic-dissection-is-associated-with-reduced-polycystin-1-expression-an-abnormality-that-leads-to-increased-erk-phosphorylation-in-vascular-smooth-muscle-cells
#7
J Feng, S Ge, L Zhang, H Che, C Liang
The vascular smooth muscle cell (VSMC) phenotypic switch is a key pathophysiological change in various cardiovascular diseases, such as aortic dissection (AD), with a high morbidity. Polycystin-1 (PC1) is significantly downregulated in the VSMCs of AD patients. PC1 is an integral membrane glycoprotein and kinase that regulates different biological processes, including cell proliferation, apoptosis, and cell polarity. However, the role of PC1 in intracellular signaling pathways remains poorly understood. In this study, PC1 downregulation in VSMCs promoted the expression of SM22α, ACTA2 and calponin 1 (CNN1) proteins...
December 16, 2016: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/28076357/soil-leaf-and-root-ecological-stoichiometry-of-caragana-korshinskii-on-the-loess-plateau-of-china-in-relation-to-plantation-age
#8
Quanchao Zeng, Rattan Lal, Yanan Chen, Shaoshan An
Caragana korshinskii, a leguminous shrub, a common specie, is widely planted to prevent soil erosion on the Loess Plateau. The objective of this study was to determine how the plantation ages affected soil, leaf and root nutrients and ecological stoichiometry. The chronosequence ages of C. korshinskii plantations selected for this study were 10, 20 and 30 years. Soil organic carbon (SOC) and soil total nitrogen (STN) of C. korshinskii plantations significantly increased with increase in the chronosequence age...
2017: PloS One
https://www.readbyqxmd.com/read/28075602/enantioselective-hydrophosphonylation-of-in-situ-generated-n-acyl-ketimines-catalyzed-by-binol-derived-phosphoric-acid
#9
Arun Suneja, Rajshekhar A Unhale, Vinod K Singh
An efficient route to pharmacologically interesting isoindolinone-based α-amino phosphonates is described via asymmetric hydrophosphonylation of in situ generated ketimines catalyzed by BINOL-derived phosphoric acid. The reaction proceeds smoothly at ambient temperature affording a variety of α-amino phosphonates with a quaternary stereogenic center embedded in isoindolinone motif in high yields with excellent enantiomeric ratios (up to 98.5:1.5 er). Several interesting transformations of the products into valuable synthetic intermediates are also depicted...
January 11, 2017: Organic Letters
https://www.readbyqxmd.com/read/28073554/an-overview-of-cyanobacterial-bloom-occurrences-and-research-in-africa-over-the-last-decade
#10
REVIEW
L L Ndlela, P J Oberholster, J H Van Wyk, P H Cheng
Cyanobacterial blooms are a current cause for concern globally, with vital water sources experiencing frequent and increasingly toxic blooms in the past decade. These increases are resultant of both anthropogenic and natural factors, with climate change being the central concern. Of the more affected parts of the world, Africa has been considered particularly vulnerable due to its historical predisposition and lag in social economic development. This review collectively assesses the available information on cyanobacterial blooms in Africa as well as any visible trends associated with reported occurrences over the last decade...
December 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073495/influence-of-nitrogen-availability-on-the-expression-of-genes-involved-in-the-biosynthesis-of-saxitoxin-and-analogs-in-cylindrospermopsis-raciborskii
#11
Paula Vico, Luis Aubriot, Fátima Martigani, Natalia Rigamonti, Sylvia Bonilla, Claudia Piccini
The development of cyanobacterial blooms in inland aquatic ecosystems is greatly promoted by nutrient availability, especially nitrogen and phosphorous. When blooms are dominated by toxigenic species the harmful effects of nutrient loading becomes particularly relevant. Among toxic species, Cylindrospermopsis raciborskii found in South American ecosystems is characterized by the production of saxitoxin and analogs (Paralytic Shellfish Poisoning, PSP), for which the factors that trigger their production have not been elucidated...
June 2016: Harmful Algae
https://www.readbyqxmd.com/read/28071869/synthesis-and-luminescence-properties-of-casno3-bi-3-blue-phosphor-and-the-emission-improvement-by-li-ion
#12
Renping Cao, Jinlong Zhang, Wudi Wang, Qianglin Hu, Wensheng Li, Wen Ruan, Hui Ao
CaSnO3 :Bi(3+) blue-emitting phosphor was synthesized using a high-temperature solid-state reaction method in air. The crystal structures and luminescence properties were investigated. A broad emission band peaking at ~448 nm upon excitation at 262 and 308 nm was observed in the range 330-680 nm at room temperature due to (3) P1  → (1) S0 transition of the Bi(3+) ion. The chromaticity coordinate was (0.1786, 0.1665). The optimal Bi(3+) ion concentration was ~0.6 mol% in CaSnO3 :Bi(3+) phosphor. The emission spectrum of CaSnO3 :Bi(3+) phosphor showed a blue-shift with increasing temperature from 50 to 300 K due to the influence of temperature on the electron transition of the Bi(3+) ion...
January 10, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28070702/effects-of-tributylborane-activated-adhesive-and-two-silane-agents-on-bonding-computer-aided-design-and-manufacturing-cad-cam-resin-composite
#13
Ayano Shinohara, Yohsuke Taira, Takashi Sawase
The present study was conducted to evaluate the effects of an experimental adhesive agent [methyl methacrylate-tributylborane liquid (MT)] and two adhesive agents containing silane on the bonding between a resin composite block of a computer-aided design and manufacturing (CAD/CAM) system and a light-curing resin composite veneering material. The surfaces of CAD/CAM resin composite specimens were ground with silicon-carbide paper, treated with phosphoric acid, and then primed with either one of the two silane agents [Scotchbond Universal Adhesive (SC) and GC Ceramic Primer II (GC)], no adhesive control (Cont), or one of three combinations (MT/SC, MT/GC, and MT/Cont)...
January 9, 2017: Odontology
https://www.readbyqxmd.com/read/28068635/inositol-hexa-phosphoric-acid-phytic-acid-a-nutraceuticals-attenuates-iron-induced-oxidative-stress-and-alleviates-liver-injury-in-iron-overloaded-mice
#14
Anwesha Bhowmik, Durbadal Ojha, Debayan Goswami, Rashmi Das, Nidhi S Chandra, Tapan K Chatterjee, Amit Chakravarty, Sudipa Chakravarty, Debprasad Chattopadhyay
Inositol hexa phosphoric acid (IP6) or Phytic acid, a natural antioxidant of some leguminous plants, known to act as a protective agent for seed storage in plants by suppressing iron catalyzed oxidative process. Following the same mechanism, we have tested the effect of IP6 on iron overloaded in vitro oxidative stress, and studied it's in vivo hepatoprotective ability in iron-dextran (injection)-induced iron overloaded liver injury in mice (intraperitoneal). Our results showed that IP6 had in vitro iron chelation (IC50 38...
January 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28067495/upconversion-nanocrystals-mediated-lateral-flow-nanoplatform-for-in-vitro-detection
#15
Zhiqin Liang, Xiaochen Wang, Wei Zhu, Pingping Zhang, Yongxin Yang, Chongyun Sun, Junjie Zhang, Xinrui Wang, Zheng Xu, Yong Zhao, Ruifu Yang, Suling Zhao, Lei Zhou
Upconversion phosphors (UCPs) that are free from interference from biological sample autofluorescence have attracted attention for in vivo and in vitro bio-applications. However, UCPs need to be water-dispersible, nanosized, and highly luminous to realize broad applications. Therefore, the aim of this research is to develop UCPs that meet these comprehensive criteria for in vitro diagnosis. To combine nanosize with high luminous intensity, β-NaYF4:Yb3+,Er3+ upconversion nanocrystals (UCNPs) codoped with Li+ and K+ are prepared that display high upconversion intensities as well as small size...
January 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28064488/palladium-catalyzed-enantioselective-c-h-activation-of-aliphatic-amines-using-chiral-anionic-binol-phosphoric-acid-ligands
#16
Adam P Smalley, James D Cuthbertson, Matthew J Gaunt
The design of an enantioselective Pd(II)-catalyzed enantioselective C-H amination reaction enabled by a comprehensive understanding of the reaction mechanism is described. The use of a chiral phosphoric acid ligand enables the conversion of readily available amines into synthetically valuable aziridines in high enantiomeric ratios. The aziridines can be derivatized to afford a range of chiral amine building blocks incorporating motifs readily encountered in pharmaceutically relevant molecules.
January 9, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28064454/hgf-met-in-cancer-progression-and-biomarker-discovery
#17
REVIEW
Kunio Matsumoto, Masataka Umitsu, Dinuka M De Silva, Arpita Roy, Donald P Bottaro
Signaling driven by hepatocyte growth factor (HGF) and MET receptor facilitates conspicuous biological responses such as epithelial cell migration, 3-D morphogenesis, and survival. The dynamic migration and promotion of cell survival induced by MET activation are bases respectively for invasion-metastasis and resistance against targeted drugs in cancers. Recent studies indicated that MET in tumor-derived exosomes facilitates metastatic niche formation and metastasis in malignant melanoma. In lung cancer, gene amplification-induced MET activation and ligand-dependent MET activation in autocrine/paracrine manner are causes for resistance to EGF receptor tyrosine kinase inhibitors and ALK inhibitors...
January 8, 2017: Cancer Science
https://www.readbyqxmd.com/read/28063361/nutrient-recycle-from-defatted-microalgae-aurantiochytrium-with-hydrothermal-treatment-for-microalgae-cultivation
#18
Taku Michael Aida, Ryouma Maruta, Yuuhiko Tanabe, Minori Oshima, Toshiyuki Nonaka, Hiroki Kujiraoka, Yasuaki Kumagai, Masaki Ota, Iwane Suzuki, Makoto M Watanabe, Hiroshi Inomata, Richard L Smith
Defatted heterotrophic microalgae (Aurantiochytrium limacinum SR21) was treated with high temperature water (175-350°C, 10-90min) to obtain nitrogen and phosphorous nutrients as a water soluble fraction (WS). Yields of nitrogen and phosphorous recovered in WS varied from 38 to 100% and from 57 to 99%, respectively. Maximum yields of nitrogen containing compounds in WS were proteins (43%), amino acids (12%) and ammonia (60%) at treatment temperatures of 175, 250 and 350°C, respectively. Maximum yield of phosphorous in WS was 99% at a treatment temperature of 250°C...
December 24, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/28061477/autocrine-vegf-signaling-promotes-cell-proliferation-through-a-plc-dependent-pathway-and-modulates-apatinib-treatment-efficacy-in-gastric-cancer
#19
Yi Lin, Ertao Zhai, Bing Liao, Lixia Xu, Xinhua Zhang, Sui Peng, Yulong He, Shirong Cai, Zhirong Zeng, Minhu Chen
BACKGROUND: Tumor cells produce vascular endothelial growth factor (VEGF) which interact with the membrane or cytoplasmic VEGF receptors (VEGFRs) to promote cell growth in an angiogenesis-independent fashion. Apatinib, a highly selective VEGFR2 inhibitor, is the only effective drug for patients with terminal gastric cancer (GC) who have no other chemotherapeutic options. However, its treatment efficacy is still controversy and the mechanism behind remains undetermined. In this study, we aimed to investigate the role of autocrine VEGF signaling in the growth of gastric cancer cells and the efficacy of Apatinib treatment...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28060542/puerarin-protects-against-endothelial-dysfunction-and-end-organ-damage-in-ang-ii-induced-hypertension
#20
Xiaojie Li, Yuhan Lin, Hongyu Zhou, Yao Li, Aimei Wang, Hongxin Wang, Ming-Sheng Zhou
Puerarin, a major isoflavonoid compound from Chinese herb Kudzu roots, has been widely used for the treatment of hypertensive and cardiovascular diseases in China. Here, we investigated puerarin's beneficial effects on the cardiovascular system in angiotensin (Ang) II-induced hypertensive rats. Sprague-Dawley rats were treated with Ang II for 5 days or with puerarin for 10 days followed by Ang II and puerarin for 5 days. Endothelium-dependent relaxation (EDR) to acetylcholine was determined using an organ chamber bath...
January 6, 2017: Clinical and Experimental Hypertension: CHE
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