keyword
https://read.qxmd.com/read/38493143/low-intensity-pulsed-ultrasound-delays-the-progression-of-osteoarthritis-by-regulating-the-yap-ripk1-nf-%C3%AE%C2%BAb-axis-and-influencing-autophagy
#1
JOURNAL ARTICLE
Chunran Pan, Fan Lu, Xiaoxia Hao, Xiaofeng Deng, Jiawei Liu, Kai Sun, Wenjie Hou, Xingru Shang, Ruimin Chi, Fengjing Guo, Tao Xu
BACKGROUND: Osteoarthritis (OA) is a degenerative disease characterized by chronic inflammation of the joint. As the disease progresses, patients will gradually develop symptoms such as pain, physical limitations and even disability. The risk factors for OA include genetics, gender, trauma, obesity, and age. Unfortunately, due to limited understanding of its pathological mechanism, there are currently no effective drugs or treatments to suspend the progression of osteoarthritis. In recent years, some studies found that low-intensity pulsed ultrasound (LIPUS) may have a positive effect on osteoarthritis...
March 16, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38406107/ultrasound-measurement-of-femoral-articular-cartilage-thickness-before-and-after-marathon-running
#2
JOURNAL ARTICLE
Matthew K Lunser, Mark Friedrich Hurdle, Walter C Taylor, Raphael A O Bertasi, Tais G O Bertasi, Svetlana Kurklinsky, George M Cooper, Hillary W Garner, Haytham Helmi, George G A Pujalte
OBJECTIVE: The purpose of this study was to use ultrasonography to measure femoral articular cartilage thickness changes during marathon running, which could support MRI studies showing that deformation of knee cartilage during long-distance running is no greater than that for other weight-bearing activities. MATERIALS AND METHODS: Participants included 38 marathon runners with no knee pain or history of knee injury, aged 18-39. Ultrasound images of the femoral articular cartilage were taken two hours before and immediately after the race...
January 2024: Curēus
https://read.qxmd.com/read/38381030/periostial-and-cartilage-morphology-in-knee-osteoarthritis-beneficial-effects-of-supplementation-with-pycnogenol%C3%A2-centellicum%C3%A2
#3
JOURNAL ARTICLE
Gianni Belcaro, Maria R Cesarone, Claudia Scipione, Valeria Scipione, Morio Hosoi, Shu Hu, Andrea Ledda, Beatrice Feragalli, Roberto Cotellese, David Cox
BACKGROUND: The aim of this registry study was to evaluate the progress of osteoarthrosis (OA) symptoms after the intake of a new standardized supplement combination (Pycnogenol® + Centellicum® , both Horphag Research) in a group of subjects with OA. METHODS: Supplemented subjects took daily 150 mg Pycnogenol® + 450 mg Centellicum® for 6 months. Another comparable group of subjects using only standard management (SM) was included as a reference...
February 2024: Minerva surgery
https://read.qxmd.com/read/38329562/characteristics-of-acute-cartilage-response-after-mechanical-loading-in-patients-with-early-mild-knee-osteoarthritis
#4
JOURNAL ARTICLE
Shogo Okada, Masashi Taniguchi, Masahide Yagi, Yoshiki Motomura, Sayaka Okada, Kaede Nakazato, Yoshihiro Fukumoto, Masashi Kobayashi, Kyoseki Kanemitsu, Noriaki Ichihashi
This study determined whether the acute cartilage response, assessed by cartilage thickness and echo intensity, differs between patients with early-mild knee osteoarthritis (OA) and healthy controls. We recruited 56 women aged ≥ 50 years with Kellgren-Lawrence (KL) grade ≤ 2 (age, 70.6 ± 7.4 years; height, 153.7 ± 5.2 cm; weight, 51.9 ± 8.2 kg). Based on KL grades and knee symptoms, the participants were classified into control (KL ≤ 1, asymptomatic, n = 27) and early-mild knee OA groups (KL 1 and symptomatic, KL 2, n = 29)...
February 8, 2024: Annals of Biomedical Engineering
https://read.qxmd.com/read/38325497/medical-imaging-applications-developed-using-artificial-intelligence-demonstrate-high-internal-validity-yet-are-limited-in-scope-and-lack-external-validation
#5
REVIEW
Jacob F Oeding, Aaron J Krych, Andrew D Pearle, Bryan T Kelly, Kyle N Kunze
PURPOSE: To (1) review definitions and concepts necessary to interpret applications of deep learning (DL; a domain of artificial intelligence (AI) that leverages neural networks to make predictions on media inputs such as images); and (2) identify knowledge and translational gaps in the literature to provide insight into specific areas for improvement as adoption of this technology continues. METHODS: A comprehensive search of the literature was performed in December 2023 for articles regarding the use of DL in sports medicine...
February 5, 2024: Arthroscopy
https://read.qxmd.com/read/38318848/continuous-low-intensity-ultrasound-improves-cartilage-repair-in-rabbit-model-of-subchondral-injury
#6
JOURNAL ARTICLE
Anuradha Subramanian, Sarayu Bhogoju, Oraine Snaith, April Miller, Heather Newell, Denzhi Wang, Gene Siegal, Katelin Oborny, Jesse Baumann-Berg, Hendrik Viljoen
Subchondral drilling (SD), a bone marrow stimulation technique, is used to repair cartilage lesions that lack regenerative potential. Cartilage repair outcomes upon SD are typically fibrocartilaginous in nature with inferior functionality. The lack of cues to foster the chondrogenic differentiation of egressed mesenchymal stromal cells (MSCs) upon SD, can be attributed for the poor outcomes. Continuous low-intensity ultrasound (cLIUS) at 3.8 MHz is proposed as a treatment modality for improving cartilage repair outcomes upon marrow stimulation...
February 6, 2024: Tissue Engineering. Part A
https://read.qxmd.com/read/38304367/ultrasonographic-evaluation-of-femoral-cartilage-thickness-in-participants-with-asymptomatic-hyperuricemia-a-case-control-study
#7
JOURNAL ARTICLE
İlker Fatih Sari, Fazıl Kulakli, Nurçe Çilesizoğlu Yavuz, İlker Ilhanli, Canan Çelik Içen
The aim was to evaluate the effect, if any, of asymptomatic hyperuricemia on distal femoral cartilage thickness through musculoskeletal ultrasonography. A total of 66 participants were evaluated in this prospective, controlled study, including 33 asymptomatic hyperuricemic patients who presented at our outpatient clinic between January and April 2020, and 33 normouricemic subjects matched for age, gender and body mass index. Participants with systemic diseases affecting uric acid level such as chronic renal failure, psoriasis, gout, etc...
April 2023: Acta Clinica Croatica
https://read.qxmd.com/read/38277686/current-advances-in-engineering-meniscal-tissues-insights-into-3d-printing-injectable-hydrogels-and-physical-stimulation-based-strategies
#8
JOURNAL ARTICLE
Ashutosh Bandyopadhyay, Baishali Ghibhela, Biman B Mandal
Knee meniscus is the cushioning fibro-cartilage tissue present in between the femoral condyles and tibial plateau of knee joint. It is largely avascular in nature and suffers from a wide range of tears and injuries caused by accidents, trauma, active lifestyle of the populace and old age of individuals. Healing of meniscus is especially difficult due to their avascularity and hence requires invasive arthroscopic approaches such as surgical resection, suturing or implantation. Though various tissue engineering approaches are proposed for treatment of meniscus tears, 3D printing/bioprinting, injectable hydrogels and physical stimulation involving modalities are gaining forefront in the past decade...
January 26, 2024: Biofabrication
https://read.qxmd.com/read/38251579/development-and-validation-of-an-omeract-ultrasound-scoring-system-for-the-extent-of-calcium-pyrophosphate-crystal-deposition-at-the-joint-level-and-patient-level
#9
JOURNAL ARTICLE
Silvia Sirotti, Lene Terslev, Emilio Filippucci, Annamaria Iagnocco, Ingrid Moller, Esperanza Naredo, Florentin A Vreju, Antonella Adinolfi, Fabio Becce, Hilde Berner Hammer, Tomas Cazenave, Edoardo Cipolletta, Sara Nysom Christiansen, Andrea Delle Sedie, Mario Diaz, Fabiana Figus, Peter Mandl, Daryl MacCarter, Mohamed A Mortada, Gael Mouterde, Francesco Porta, Anthony M Reginato, Wolfgang A Schmidt, Teodora Serban, Richard J Wakefield, Pascal Zufferey, Piercarlo Sarzi-Puttini, Anna Zanetti, Arianna Damiani, Carlos Pineda, Helen I Keen, Maria Antonietta D'Agostino, Georgios Filippou
BACKGROUND: The Calcium Pyrophosphate Deposition (CPPD) subgroup of the Outcome Measures in Rheumatology (OMERACT) Ultrasound working group was established to validate ultrasound as an outcome measure instrument for CPPD, and in 2017 has developed and validated standardised definitions for elementary lesions for the detection of calcium pyrophosphate crystals in joints. The aim of this study was to develop and evaluate the reliability of a consensus-based ultrasound scoring system for CPPD extent, representing the next phase in the OMERACT methodology...
August 2023: Lancet Rheumatology
https://read.qxmd.com/read/38249085/experimental-ultrasound-approach-for-studying-knee-intra-articular-femur-tibia-movements-under-different-loads
#10
JOURNAL ARTICLE
Ivan Ivanov, Sergey Ranchev, Stoyan Stoychev
The purpose of the present study was to develop an experimental model for the study of intra-articular knee movements depending on the function of the knee joint and involved muscle groups under isometric stretching conditions with different loads. The experimental procedure included an ultrasound examination of a knee joint after isometric stretching in healthy men ( n = 32). The changes (in millimeters) in the distances between the femur and tibia were measured using an ultrasound sonographer at three stages...
December 29, 2023: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38248060/ultrasound-imaging-of-the-articularis-genus-muscle-implications-for-ultrasound-guided-suprapatellar-recess-injection
#11
JOURNAL ARTICLE
Wei-Ting Wu, Ke-Vin Chang, Ondřej Naňka, Kamal Mezian, Vincenzo Ricci, Bow Wang, Levent Özçakar
Elucidating its dynamic interaction within the knee joint, this exploration delves into the awareness regarding the articularis genus muscle for ultrasound-guided suprapatellar recess injections. While injections into the infrapatellar recess may proceed without ultrasound guidance, we highlight concerns regarding the potential cartilage injury. In contrast, especially with ultrasound guidance, suprapatellar recess injections significantly mitigate this risk, especially in the case of collapsed recess. Originating from the distal femur and vastus intermedius, the articularis genus muscle influences the tension of the suprapatellar recess during knee motion...
January 14, 2024: Diagnostics
https://read.qxmd.com/read/38238250/high-speed-centrifugation-efficiently-removes-immunogenic-elements-in-osteochondral-allografts
#12
JOURNAL ARTICLE
Yongsheng Ma, Qitai Lin, Wenming Yang, Yang Liu, Yugang Xing, Zhiyuan Ren, Xueding Wang, Raorao Zhou, Gaige Wu, Pengcui Li, Wangping Duan, Xiaoling Zhang, Xiaochun Wei
OBJECTIVES: The current clinical pulse lavage technique for flushing fresh osteochondral allografts (OCAs) to remove immunogenic elements from the subchondral bone is ineffective. This study aimed to identify the optimal method for removing immunogenic elements from OCAs. METHODS: We examined five methods for the physical removal of immunogenic elements from OCAs from the femoral condyle of porcine knees. We distributed the OCAs randomly into the following seven groups: (1) control, (2) saline, (3) ultrasound, (4) vortex vibration (VV), (5) low-pulse lavage (LPL), (6) high-pulse lavage (HPL), and (7) high-speed centrifugation (HSC)...
January 18, 2024: Orthopaedic Surgery
https://read.qxmd.com/read/38161708/daily-low-intensity-pulsed-ultrasound-stimulation-mitigates-joint-degradation-and-pain-in-a-post-traumatic-osteoarthritis-rat-model
#13
JOURNAL ARTICLE
Wonsae Lee, Elias Georgas, David E Komatsu, Yi-Xian Qin
OBJECTIVES: The aim of this study was to investigate the effects of low-intensity pulsed ultrasound (LIPUS) in a post-traumatic osteoarthritis (OA) rat model and in vitro . METHODS: Thirty-eight male, four-month-old Sprague Dawley rats were randomly assigned to Sham, Sham ​+ ​US, OA, and OA ​+ ​US. Sham surgery was performed to serve as a negative control, and anterior cruciate ligament transection was used to induce OA...
January 2024: Journal of Orthopaedic Translation
https://read.qxmd.com/read/38153540/evaluation-of-meniscal-elasticity-using-shear-wave-elastography-in-obese-children-and-adolescents-a-preliminary-cross-sectional-study
#14
JOURNAL ARTICLE
Nurullah Dag, Muhammed S Sinanoglu
BACKGROUND: Musculoskeletal problems such as pain, joint pathology, increased risk of fracture, and the development of structural deformities are common in childhood obesity. Increased mechanical stress on the knee joint leads to degenerative changes in the cartilage and meniscus. Meniscal elasticity values increase in meniscal degeneration. Shear wave elastography (SWE) is an ultrasound-based imaging technique based on the principle of measuring tissue elasticity. OBJECTIVE: We aimed to investigate the changes in meniscal stiffness and thickness that can be caused by obesity in children and adolescents using SWE...
December 28, 2023: Pediatric Radiology
https://read.qxmd.com/read/38125054/the-short-term-effect-of-glucosamine-sulfate-nonanimal-chondroitin-sulfate-and-s-adenosylmethionine-combination-on-ultrasonography-findings-inflammation-pain-and-functionality-in-patients-with-knee-osteoarthritis-a-pilot-double-blind-randomized-placebo-controlled
#15
JOURNAL ARTICLE
Zoran Veličković, Slavica Pavlov Dolijanović, Nikola Stojanović, Saša Janjić, Ljiljana Kovačević, Ivan Soldatović, Goran Radunović
OBJECTIVES: This study aimed to investigate the efficacy of glucosamine-sulfate (GS), nonanimal chondroitin-sulfate (naCS), and S-adenosylmethionine (SAMe) combination on ultrasound findings, inflammation, pain, and functionality in knee osteoarthritis. PATIENTS AND METHODS: In the prospective, randomized, double-blind, placebo-controlled pilot study conducted between August 2019 and November 2019, 120 participants (28 males, 92 females; mean age: 66.4±7.9 years; range, 42...
December 2023: Archives of Rheumatology
https://read.qxmd.com/read/37992754/functional-imaging-of-the-knee-a-comprehensive-review
#16
JOURNAL ARTICLE
Kenneth C Kim, Brooke Wakeman, Rob Wissman
Knee pain is a common presenting problem in the general population. Radiographs and MRI are the cornerstones of imaging in current clinical practice. With advancements in technology, there has been increasing utilization of other modalities to evaluate knee disorders. Dynamic assessment utilizing computed tomography and portable ultrasounds have demonstrated the capacity to accurately assess and reproducibly quantify kinematics of knee disorders. Cartilage physiology can be further evaluated with magnetic resonance imaging...
November 22, 2023: Journal of Knee Surgery
https://read.qxmd.com/read/37986308/effects-of-extracorporeal-shockwave-therapy-for-mild-knee-osteoarthritis-a-pilot-study
#17
RANDOMIZED CONTROLLED TRIAL
I Jun Choi, Jong Hu Jeon, Woo Hwa Choi, Hea-Eun Yang
BACKGROUND: Extracorporeal shockwave therapy (ESWT) has been widely used for various musculoskeletal disorders, including knee osteoarthritis (OA), and has been shown in several studies to be a safe treatment. Although some studies have confirmed the pain-relieving effect of ESWT for knee OA, research on objectivity for structural changes in knee OA is lacking. The aim of this study was to evaluate the ESWT treatment mechanisms in patients with knee OA by means of clinical symptoms and ultrasound techniques as objective measures...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37975949/ultrasound-reveals-a-high-prevalence-of-cppd-in-consecutive-patients-with-knee-pain
#18
JOURNAL ARTICLE
Edoardo Cipolletta, Francesca Francioso, Gianluca Smerilli, Jacopo Di Battista, Emilio Filippucci
The objective of this study is to estimate the prevalence of US findings indicative of calcium pyrophosphate deposition (CPPD) in patients with knee pain. Consecutive patients with knee pain, equally distributed among males and females in seven different age-decades (21-90 years), were enrolled in a cross-sectional study. The presence of US OMERACT-defined CPPD (medial and lateral menisci and femoral hyaline cartilage) and osteophytes (medial and lateral compartments of the tibiofemoral joint) was scored as presence/absence in both knees...
November 17, 2023: Clinical Rheumatology
https://read.qxmd.com/read/37969633/imaging-of-knee-osteoarthritis-a-review-of-multimodal-diagnostic-approach
#19
REVIEW
Claudia Lucia Piccolo, Carlo Augusto Mallio, Federica Vaccarino, Rosario Francesco Grasso, Bruno Beomonte Zobel
Knee osteoarthritis (KOA) is a common chronic condition among the elderly population that significantly affects the quality of life. Imaging is crucial in the diagnosis, evaluation, and management of KOA. This manuscript reviews the various imaging modalities available until now, with a little focus on the recent developments with Artificial Intelligence. Currently, radiography is the first-line imaging modality recommended for the diagnosis of KOA, owing to its wide availability, affordability, and ability to provide a clear view of bony components of the knee...
November 1, 2023: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/37916658/diagnostic-value-of-the-head-us-c-scale-for-the-knees-of-severe-hemophilia-a-patients
#20
JOURNAL ARTICLE
Yunmei Fang, Rui Sun, Jingxuan Chang, Cuiming Zhang
OBJECTIVES: This study aimed to assess the reliability of the Hemophilia Early Arthropathy Detection with Ultrasound in China (HEAD-US-C) scale for the knees of severe hemophilia A (SHA) patients and to determine its diagnostic accuracy for assessments of knee-joint lesions in comparison with magnetic resonance imaging (MRI). METHODS: We collected data from 32 knee joints of 21 patients diagnosed with SHA. The knees were evaluated based on the HEAD-US-C scale and the results were compared with the International Prevention Study Group (IPSG) scale...
November 2, 2023: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
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