Yingfei Li, Yi He, Fangyuan Yang, Rongmei Liang, Wenchao Xu, Yehao Li, Jingbo Cheng, Baozhu Liang, Ming Tang, Xingliang Shi, Jian Zhuang, Minshuang Luo, Liuying Li, Ruilin Zhang, Huijuan Liu, Hongyu Jie, Xing Li, Xinai Han, Erwei Sun, Zeqing Zhai
OBJECTIVE: Psoriasis is a common, chronic inflammatory disease with unclear etiology. Keratinocytes in psoriasis are susceptible to exogenous triggers that induce inflammatory cell death. This study investigated whether GSDME-mediated pyroptosis in keratinocytes contributes to the pathogenesis of psoriasis. METHODS: Skin samples from patients with psoriasis and healthy controls were collected to evaluate the expression of GSDME, cleaved-caspase-3, and inflammatory factors...
April 24, 2024: British Journal of Dermatology