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https://www.readbyqxmd.com/read/28345956/modulation-of-steroidogenesis-by-vitamin-d3-in-granulosa-cells-of-the-mouse-model-of-polycystic-ovarian-syndrome
#1
Shabnam Bakhshalizadeh, Fardin Amidi, Ashraf Alleyassin, Masoud Soleimani, Reza Shirazi, Maryam Shabani Nashtaei
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder of women of reproductive age characterized by polycystic ovarian morphology, anovulation or oligomenorrhea, and hyperandrogenism. It is shown that disruption in the steroidogenesis pathway caused by excess androgen in PCOS is a critical element of abnormal folliculogenesis and failure in dominant follicle selection. Vitamin D plays an important role in the regulation of ovulatory dysfunction and can influence genes involved in steroidogenesis in granulosa cells...
March 27, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28344194/an-administration-of-tak-683-at-a-minimally-effective-dose-for-luteinizing-hormone-stimulation-under-the-absence-of-the-ovary-induces-luteinizing-hormone-surge-in-ovary-intact-goats
#2
Nahoko Kanai, Natsumi Endo, Satoshi Ohkura, Yoshihiro Wakabayashi, Hisanori Matsui, Hirokazu Matsumoto, Kaori Ishikawa, Akira Tanaka, Tatsuya Watanabe, Hiroaki Okamura, Tomomi Tanaka
The present study aimed to evaluate hormonal responses and their association with the TAK-683 blood concentrations in goats administered TAK-683 at a low dose, which had been previously determined as the minimally effective dose for luteinizing hormone (LH) stimulation in ovariectomized goats. In Experiment 1, 5 µg of TAK-683 treatment had no significant stimulatory effect on LH secretion in ovariectomized Shiba goats (n = 4). In Experiment 2, cycling goats received the treatment of prostaglandin F2α and progesterone-releasing controlled internal drug releasing (CIDR) to induce the follicular phase, then they were treated with 5 µg of TAK-683 (hour 0) intravenously (n = 4, IV) or subcutaneously (n = 3, SC) or with vehicle intravenously (n = 4, control) at 12 h after CIDR removal...
March 24, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/28344192/effect-of-investigational-kisspeptin-metastin-analog-tak-683-on-luteinizing-hormone-secretion-at-different-stages-of-the-luteal-phase-in-goats
#3
Larasati Puji Rahayu, Mohammed El Behiry, Natsumi Endo, Tomomi Tanaka
This study aimed to examine the response of luteinizing hormone (LH) secretion and ovarian steroid profile to TAK-683, an investigational metastin/kisspeptin analog, through treatment during different stages of the luteal phase in goats. Nine cycling Shiba goats (4.4 ± 2.3 years old) were assigned to early luteal phase (ELP, n = 4), mid-luteal phase (MLP, n = 4), and control (n = 5) groups. The ELP and MLP groups were administered 50 µg of TAK-683 intravenously on either day 5 or between days 7-14 after ovulation, respectively...
March 25, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/28342866/the-t47d-cell-line-is-an-ideal-experimental-model-to-elucidate-the-progesterone-specific-effects-of-a-luminal-a-subtype-of-breast-cancer
#4
Sungryul Yu, Taemook Kim, Kyung Hyun Yoo, Keunsoo Kang
Cell lines are often used as in vitro tools to mimic certain types of in vivo system; several cell lines, including MCF-7 and T47D, have been widely used in breast cancer studies without investigating the cell lines' characteristics. In this study, we compared the genome-wide binding profiles of ERα, PR, and P300, and the gene expression changes between MCF-7 and T47D cell lines that represent the luminal A subtype of breast cancer. Surprisingly, several thousand genes were differentially expressed under estrogenic condition...
March 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28342689/induction-of-out-of-season-egg-laying-by-artificial-photoperiod-in-yangzhou-geese-and-the-associated-endocrine-and-molecular-regulation-mechanisms
#5
Huanxi Zhu, Xibing Shao, Zhe Chen, Chuankun Wei, Mingming Lei, Shijia Ying, Jianning Yu, Zhendan Shi
This study was carried out to induce out-of-season breeding, in the summer, and to achieve high reproductive performance using artificial photoperiod manipulation in the long-day breeding Yangzhou goose. Young geese were subject to a two-phase short-to-long (group A) or a three-phase (long-short-long; group B) photoperiod program February through October. Egg-laying was induced to start similarly in both groups in May, increased to a peak level in July, and then decreased gradually through to October. The peak and post-peak laying rates were higher with the three-phase than with the two-phase program...
March 18, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28342373/using-quantum-chemical-modeling-and-calculations-for-evaluation-of-cellulose-potential-for-estrogen-micropollutants-removal-from-water-effluents
#6
Amin Ghasemi, Milad Asgarpour Khansary, Azam Marjani, Saeed Shirazian
This paper is devoted to investigate the suitability of cellulose for estrogens micropollutants removal from water effluent. For this purpose, the sorption of eight estrogens including Estradiol, Estrone, Testosterone, Progesterone, Estriol, Mestranol, Ethinylestradiol and Diethylstilbestrol were investigated. The charge density profiles and sorption curves were obtained and discussed using quantum chemical calculations where the Accelrys Materials Studio software and COSMO-SAC model were employed. The geometry optimization of compound molecule and energy minimizations was performed using the Dmol3 Module and density functional theory of generalized gradient approximate and Volsko-Wilk-Nusair functional...
March 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28341842/a-scoring-system-to-predict-breast-cancer-mortality-at-5-and-10-years
#7
Esther Paredes-Aracil, Antonio Palazón-Bru, David Manuel Folgado-de la Rosa, José Ramón Ots-Gutiérrez, Antonio Fernando Compañ-Rosique, Vicente Francisco Gil-Guillén
Although predictive models exist for mortality in breast cancer (BC) (generally all cause-mortality), they are not applicable to all patients and their statistical methodology is not the most powerful to develop a predictive model. Consequently, we developed a predictive model specific for BC mortality at 5 and 10 years resolving the above issues. This cohort study included 287 patients diagnosed with BC in a Spanish region in 2003-2016. MAIN OUTCOME VARIABLE: time-to-BC death. Secondary variables: age, personal history of breast surgery, personal history of any cancer/BC, premenopause, postmenopause, grade, estrogen receptor, progesterone receptor, c-erbB2, TNM stage, multicentricity/multifocality, diagnosis and treatment...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28341760/intratumoral-heterogeneity-in-breast-cancer-a-comparison-of-primary-and-metastatic-breast-cancers
#8
Yu-Jie Shi, Julia Y S Tsang, Yun-Bi Ni, Gary M Tse
Intratumoral heterogeneity presents challenges in the management of cancer. To gain deeper insight in intratumoral heterogeneity at different levels and tumor sites for common biomarkers in breast cancers, this report examines seven cases of invasive breast cancer with multiple axillary nodal metastases and/or recurrences for immunohistochemical expression of estrogen receptors, progesterone receptors, human epidermal growth receptor 2, and Ki67 on all tissue blocks in both primary and metastatic tumors. The Oncologist 2017;22:1-4...
March 24, 2017: Oncologist
https://www.readbyqxmd.com/read/28341573/quercetin-alters-uterine-fluid-volume-and-aquaporin-aqp-subunits-aqp-1-2-5-7-expression-in-the-uterus-in-the-presence-of-sex-steroids-in-rats
#9
Huma Shahzad, Nelli Giribabu, Kamarulzaman Karim, Sekaran Muniandy, Normadiah M Kassim, Naguib Salleh
Effects of quercetin on uterine fluid volume and aquaporin (AQP) expression in the uterus were investigated. Estradiol (E) or estradiol followed by progesterone (E+P) were given to ovariectomised rats with or without quercetin (10, 50 or 100mg/kg/day) treatment. Uteri were harvested and its inner/outer circumference ratio was determined. AQP-1, 2, 5 and 7 mRNA and protein levels in uterus were quantified by Real-time PCR and Western blotting respectively. Protein distribution was observed by immunohistochemistry...
March 21, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28341393/cell-specific-immuno-localization-of-progesterone-receptor-alpha-in-the-rabbit-ovary-during-pregnancy-and-after-parturition
#10
Mahmoud Abd-Elkareem
Progesterone receptor alpha (PRA) has a central coordinator role in the ovarian functions in mammals. The aim of this study was to investigate the immunolocalization of PRA in the rabbit ovary during pregnancy and after parturition. The rabbit ovary during pregnancy and after parturition had moderate cytoplasmic and moderate to intense nuclear PRA immunostaining in the ovarian surface epithelial cells, stromal cells and interstitial gland cells. The PRA was also present in granulosa cells and theca interna cells of the growing, small antral and mature Graafian follicles...
March 18, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28341031/surveillance-of-women-with-a-personal-history-of-breast-cancer-by-tumour-subtype
#11
A P Benveniste, M J Dryden, I Bedrosian, P K Morrow, R L Bassett, W Yang
AIM: To determine if the rate and timing of a second breast cancer event (SBCE) in women with a personal history of breast cancer varies by disease subtype or breast imaging method. MATERIALS AND METHODS: A retrospective review was performed of women with a SBCE from January 2006 to December 2010 at a single institution. Data analysed included oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) status of the primary and second breast cancers; mammographic and ultrasound (US) features from SBCE; and the time interval between both events...
March 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28340932/predicting-first-trimester-pregnancy-outcome-derivation-of-a-multiple-marker-test
#12
Suneeta Senapati, Mary D Sammel, Samantha F Butts, Peter Takacs, Karine Chung, Kurt T Barnhart
OBJECTIVE: To predict first trimester pregnancy outcome using biomarkers in a multicenter cohort. DESIGN: Case-control study. SETTING: Three academic centers. PATIENT(S): Women with pain and bleeding in early pregnancy. INTERVENTION(S): Sera from women who were 5-12 weeks' gestational age with ectopic pregnancy (EP), viable intrauterine pregnancy (IUP), and miscarriage/spontaneous abortion (SAB) was analyzed by ELISA and immunoassay for activin A, inhibin A, P, A Disintegrin And Metalloprotease-12, pregnancy-associated plasma protein A (PAPP-A), pregnancy specific B1-glycoprotein (SP1), placental-like growth factor, vascular endothelial growth factor, glycodelin (Glyc), and hCG...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/28340171/immunohistochemical-approach-to-the-differential-diagnosis-of-meningiomas-and-their-mimics
#13
Camille Boulagnon-Rombi, Clémence Fleury, Caroline Fichel, Sophie Lefour, Aude Marchal Bressenot, Guillaume Gauchotte
The differential diagnosis between meningioma and others tumors can be challenging. This study aimed to evaluate different immunohistochemical markers for the differential diagnosis between meningioma and their morphological mimics. Immunohistochemistry was performed on tissue microarray with antiepithelial membrane antigen (EMA), progesterone receptor, somatostatin receptor 2A (SSTR2A), CD34, STAT6, S100, SOX10, HMB45, MelanA, GFAP, inhibin, and BCL2 antibodies. One hundred and twenty-seven meningiomas, 26 solitary fibrous tumor/hemangiopericytomas (SFT/HPC), 39 schwannomas, 17 hemangioblastomas, 21 melanomas, 9 gliosarcomas, 5 neurofibromas, 9 peripheral primitive neuroectodermal tumors, 7 synovial sarcomas, and 5 malignant peripheral nerve sheath tumors were included in the microarray...
March 14, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28339778/effects-of-an-induced-molt-using-cassava-meal-on-body-weight-loss-blood-physiology-ovarian-regression-and-postmolt-egg-production-in-late-phase-laying-hens
#14
N Gongruttananun, P Kochagate, K Poonpan, N Yu-Nun, J Aungsakul, N Sopa
This study was conducted to determine the effect of an induced molt using cassava meal on body weight, blood physiology, ovary, and postmolt performance in late-phase (74 wk old) H&N Brown laying hens. Hens were randomly assigned to 3 treatments of 90 birds each: 1) Controls withno induced molt (CONT); 2) molted by full feeding with cassava meal for 3 wk (FP3); and 3) molted by full feeding with cassava meal for 4 wk (FP4). Groups 2 and 3 were fed a pullet developer diet for 3 wk following treatment. During the molt period, the birds were exposed to an 8L:16D photoperiod and had access to drinking water at all times...
February 23, 2017: Poultry Science
https://www.readbyqxmd.com/read/28339191/allosteric-activation-of-cytochrome-p450-3a4-via-progesterone-bioconjugation
#15
Vanja Polic, Karine Auclair
Human cytochrome P450 3A4 (CYP3A4) is responsible for the metabolism of the majority of drugs. As such, it is implicated in many adverse drug-drug and food-drug interactions, and is of significant interest to the pharmaceutical industry. This enzyme is known to simultaneously bind multiple ligands and display atypical enzyme kinetics, suggestive of allostery and cooperativity. As well, evidence of a postulated peripheral allosteric binding site has provoked debate around its significance and location. We report the use of bioconjugation to study the significance of substrate binding at the proposed allosteric site and its effect on CYP3A4 activity...
March 24, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28337827/prostaglandin-f2%C3%AE-induced-luteolysis-involves-activation-of-signal-transducer-and-activator-of-transcription-3-and-inhibition-of-akt-signaling-in-cattle
#16
Monique Tomazele Rovani, Gustavo Freitas Ilha, Bernardo Garziera Gasperin, Jandui Nóbrega, Dayananda Siddappa, Werner Glanzner, Alfredo Quites Antoniazzi, Vilceu Bordignon, Raj Duggavathi, Paulo Bayard Dias Gonçalves
Prostaglandin F2α (PGF) induces the precipitous loss of steroidogenic capabilities and cellular death in the corpus luteum of many species, yet the molecular mechanisms underlying this event are not completely understood. Signal transducer and activator of transcription 3 (STAT3) was activated in granulosa cells during follicle atresia, whereas AKT is immediately downregulated in the corpus luteum after PGF treatment in cattle; however, their involvement in both functional and morphological luteolysis in monovular species still need to be determined...
March 24, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28337578/evolution-of-the-corpus-luteum-volume-determined-ultrasonographically-and-its-relation-to-the-plasma-progesterone-concentration-after-artificial-insemination-in-pregnant-and-non-pregnant-dairy-cows
#17
C Gómez-Seco, B Alegre, F Martínez-Pastor, J G Prieto, J R González-Montaña, M E Alonso, J C Domínguez
The aim of this study was to assess the relationship of the evolution of the corpus luteum (CL) volume that was determined ultrasonographically with the pregnancy status in lactating dairy cows during early pregnancy. Ultrasound examinations were carried out on 76 cows following artificial insemination (AI). Plasma concentrations of progesterone were determined from blood samples collected at each ultrasound examination. Conception was confirmed by ultrasonography on day 30 after AI. Around day 14 post-insemination (p...
March 23, 2017: Veterinary Research Communications
https://www.readbyqxmd.com/read/28337559/dietary-fiber-intake-and-risk-of-breast-cancer-defined-by-estrogen-and-progesterone-receptor-status-the-japan-public-health-center-based-prospective-study
#18
Saki Narita, Manami Inoue, Eiko Saito, Sarah K Abe, Norie Sawada, Junko Ishihara, Motoki Iwasaki, Taiki Yamaji, Taichi Shimazu, Shizuka Sasazuki, Kenji Shibuya, Shoichiro Tsugane
PURPOSE: Epidemiological studies have suggested a protective effect of dietary fiber intake on breast cancer risk while the results have been inconsistent. Our study aimed to investigate the association between dietary fiber intake and breast cancer risk and to explore whether this association is modified by reproductive factors and hormone receptor status of the tumor. METHODS: A total of 44,444 women aged 45 to 74 years from the Japan Public Health Center-based Prospective Study were included in analyses...
March 23, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28336267/association-analysis-of-polymorphism-in-kiss1-gene-with-reproductive-traits-in-goats
#19
Mahmoud S El-Tarabany, Asmaa W Zaglool, Akram A El-Tarabany, Ashraf Awad
Understanding the genetic information of related genes is helpful for the selection and breeding course through marker assisted selection. The aim of the current study was to detect polymorphisms of the KiSS1 gene in 137 animals, including Baladi, Zaraibi and Damascus goat breeds by PCR-RFLP, and DNA sequencing and to investigate the association between these variants and reproductive traits. Comparison of the nucleotide sequence indicated the substitution of T with A at position 121 (T121A) in the intron 1 of the KiSS1 gene in all goat breeds...
March 18, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28336266/progesterone-and-estradiol-profiles-in-different-reproductive-stages-of-captive-collared-peccary-pecari-tajacu-females-assessed-by-fecal-metabolites
#20
Concepción Ahuja-Aguirre, Lorena López-deBuen, Susana Rojas-Maya, Bertha C Hernández-Cruz
The study determined the fecal progesterone and estradiol profiles in different reproductive stages of captive collared peccary (Pecari tajacu) females from eastern Mexico. Fifteen adult females were included. At the start of the study the females were either pregnant (early, mid, or late pregnancy), lactating, or non-lactating of unknown pregnancy status. Feces from each female were collected once a week during nine consecutive months to determine concentrations of fecal progesterone and estradiol metabolites using ELISA...
March 18, 2017: Animal Reproduction Science
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