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https://www.readbyqxmd.com/read/29228315/comparison-of-neoadjuvant-nab-paclitaxel-carboplatin-vs-nab-paclitaxel-gemcitabine-in-triple-negative-breast-cancer-randomized-wsg-adapt-tn-trial-results
#1
Oleg Gluz, Ulrike Nitz, Cornelia Liedtke, Matthias Christgen, Eva-Maria Grischke, Helmut Forstbauer, Michael Braun, Mathias Warm, John Hackmann, Christoph Uleer, Bahriye Aktas, Claudia Schumacher, Nikola Bangemann, Christoph Lindner, Sherko Kuemmel, Michael Clemens, Jochem Potenberg, Peter Staib, Andreas Kohls, Raquel von Schumann, Ronald Kates, Ronald Kates, Johannes Schumacher, Rachel Wuerstlein, Hans Heinrich Kreipe, Nadia Harbeck
Background: Pathological complete response (pCR) is associated with improved prognosis in triple-negative breast cancer (TNBC). The optimal chemotherapy regimen is unclear. Weekly nab-paclitaxel vs conventional paclitaxel or addition of carboplatin to anthracycline-taxane results in higher pCR rates with uncertain survival impact. We evaluated carboplatin vs gemcitabine with a nab-paclitaxel backbone as a short 12-week A-free regimen with a focus on early response. Methods: Patients with TNBC (estrogen receptor/progesterone receptor < 1%, human epidermal growth factor receptor 2-negative, cT1c-cT4c, cN0/+) were randomly assigned to A: nab-paclitaxel 125 mg/m2/gemcitabine 1000 mg/m2 d1,8 three times weekly (q3w); vs B: nab-paclitaxel 125 mg/m2/carboplatin AUC2 day 1,8 q3w...
December 8, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29228129/prenatal-exposure-to-di-2-ethylhexyl-phthalate-causes-long-term-transgenerational-effects-on-female-reproduction-in-mice
#2
Emily Brehm, Saniya Rattan, Liying Gao, Jodi A Flaws
Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer in many consumer products. Although DEHP is a known endocrine disruptor, little is known about the effects of DEHP exposure on female reproduction. Thus, this study tested the hypothesis that prenatal DEHP exposure affects follicle numbers, estrous cyclicity, and hormone levels in multiple generations of mice. Pregnant CD-1 mice were orally dosed with corn oil (vehicle control) or DEHP (20 and 200 µg/kg/day, and 500 and 750 mg/kg/day) from gestation day 10...
December 7, 2017: Endocrinology
https://www.readbyqxmd.com/read/29228121/low-dose-bisphenol-a-activates-the-erk-signaling-pathway-and-attenuates-steroidogenic-gene-expression-in-human-placental-cells
#3
Po-Wei Chu, Zhi-Jie Yang, Huei-Shing Huang, Ai-An Chang, Yu-Chen Cheng, Gwo-Jang Wu, Hsin-Chieh Lan
Bisphenol A (BPA) is an industrial material used for many plastic products and is considered an endocrine disruptor. BPA can be released into the environment and can spread through the food chain. It is well known that BPA exposure leads to lesions, especially in the reproductive system. According to previous studies, BPA reduces newborn numbers in pregnant mice and affects placentation. The placenta is a special endocrine organ during pregnancy. It secretes important hormones, such as progesterone and estrogen, to maintain gestation...
December 4, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29227976/progesterone-receptor-isoforms-nuclear-corepressor-1-and-steroid-receptor-coactivator-1-and-b-cell-lymphoma-2-and-akt-and-akt-phosphorylation-status-in-uterine-myomas-after-ulipristal-acetate-treatment-a-systematic-immunohistochemical-evaluation
#4
Guillaume E Courtoy, Jacques Donnez, Etienne Marbaix, Matilde Barreira, Mathieu Luyckx, Marie-Madeleine Dolmans
OBJECTIVE: To investigate whether ulipristal acetate (UPA) treatment modifies the expression of progesterone receptor (PR), its nuclear cofactors steroid receptor coactivator-1 (SRC1) and nuclear corepressor-1 (NCoR1), prosurvival factor B-cell lymphoma 2 (Bcl-2), and Akt in uterine myomas. PATIENTS: Prospective study of 59 women with symptomatic myomas undergoing myomectomy. Forty-two patients were treated preoperatively with UPA; the remaining 17 were not and they served as controls...
December 11, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29227912/annual-variations-in-sexual-hormones-and-births-frequency-in-female-stump-tailed-macaques-macaca-arctoides
#5
R Mondragón-Ceballos, M D García-Granados, G Matamoros-Trejo, L E Hernández-López
Although the breeding seasonality in Macaca arctoides have been studied over a long period of time, it is still controversial whether reproduction in this primate tend to increase during certain months of the year as it happens in most of the macaque species. Many authors have classified Macaca arctoides as not being seasonal species. Nonetheless, there were no reports, about seasonal variations of female sexual hormones to demonstrate that asseveration. Therefore, in the present study we collect 1611 fecal samples from June 2009 to November 2010 from 10 female stump-tailed macaques to measure 17β-estradiol and progesterone concentrations...
November 20, 2017: Theriogenology
https://www.readbyqxmd.com/read/29227253/-pathogenetic-features-of-the-development-of-overacive-bladder-in-women
#6
V Lesovoy, S Kolupayev
The aim of the research was to study the pathogenetic features of the development of the overactive bladder (OAB) in women. 107 women with OAB and a control group of 29 healthy women were involved into the study. The hormonal status was studied based on the determination of serum concentrations of luteinizing hormone (LH), stimulating hormone (FSH), estradiol and progesterone. The urine levels of interleukin-1β (IL-1β), interleukin-4 (IL-4), interleukin-8 (IL-8), tumor necrosis factor ά (TNF-ά) and macrophage chemotactic protein-1 (MCP-1) were assessed...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29227245/clearance-of-senescent-decidual-cells-by-uterine-natural-killer-cells-in-cycling-human-endometrium
#7
Paul J Brighton, Yojiro Maruyama, Katherine Fishwick, Pavle Vrljicak, Shreeya Tewary, Risa Fujihara, Joanne Muter, Emma S Lucas, Taihei Yamada, Laura Woods, Raffaella Lucciola, Yie Hou Lee, Satoru Takeda, Sascha Ott, Myriam Hemberger, Siobhan Quenby, Jan Joris Brosens
In cycling human endometrium, menstruation is followed by rapid estrogen-dependent growth. Upon ovulation, progesterone and rising cellular cAMP levels activate the transcription factor Forkhead box O1 (FOXO1) in endometrial stromal cells (EnSCs), leading to cell cycle exit and differentiation into decidual cells that control embryo implantation. Here we show that FOXO1 also causes acute senescence of a subpopulation of decidualizing EnSCs in an IL-8 dependent manner. Selective depletion or enrichment of this subpopulation revealed that decidual senescence drives the transient inflammatory response associated with endometrial receptivity...
December 11, 2017: ELife
https://www.readbyqxmd.com/read/29226703/sex-differences-in-the-relationship-between-global-advantage-lateralization-and-inter-hemispheric-connectivity-in-a-navon-paradigm
#8
Belinda Pletzer, TiAnni Harris
Sex, stimulus material and attention condition have previously been related to global advantage (faster responses to global targets than to local targets), as well as lateralization during global-local processing. It is presumed that the lateralization of brain functions is either related to the inhibitory influence of the dominant on the non-dominant hemisphere or reduced excitation between hemispheres. However, a direct relationship between the global advantage and lateralization, as well as inter-hemispheric connectivity has not been previously established...
December 10, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/29224870/effect-of-dose-and-timing-of-prostaglandin-f2%C3%AE-treatments-during-a-resynch-protocol-on-luteal-regression-and-fertility-to-timed-artificial-insemination-in-lactating-holstein-cows
#9
R V Barletta, P D Carvalho, V G Santos, L F Melo, C E Consentini, A S Netto, P M Fricke
Our objective was to evaluate the effect of a second PGF2α treatment (25 mg of dinoprost) or a double dose of PGF2α (50 mg of dinoprost) during a Resynch protocol on luteal regression and pregnancies per artificial insemination (P/AI) in lactating dairy cows. Lactating Holstein cows (n = 1,100) were randomly assigned at a nonpregnancy diagnosis to receive (1) Ovsynch (control: 100 µg of GnRH; 7 d, 25 mg of PGF2α; 56 h, 100 µg of GnRH), (2) Ovsynch with a second PGF2α treatment (GPPG: 100 µg of GnRH; 7 d, 25 mg of PGF2α; 24 h, 25 mg of PGF2α; 32 h, 100 µg of GnRH), or (3) Ovsynch with a double dose of PGF2α (GDDP: 100 µg of GnRH; 7 d, 50 mg of PGF2α; 56 h, 100 µg of GnRH)...
December 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29224860/estrous-detection-intensity-and-accuracy-and-optimal-timing-of-insemination-with-automated-activity-monitors-for-dairy-cows
#10
C N S LeRoy, J S Walton, S J LeBlanc
The objectives of this observational study were to assess the ability of automated activity monitoring (AAM) to detect estrus for first insemination, the accuracy of detection, and the optimum interval from the estrus alert from the AAM system to insemination. Four commercial farms using 1 of 2 commercial AAM systems were studied over 1 yr. Cows were inseminated between 55 and 80 d in milk (DIM) based on AAM only, then by a combination of AAM and timed artificial insemination (AI). Blood progesterone was measured in 1,014 cows at wk 5, 7, and 9 postpartum; purulent vaginal discharge (PVD) was assessed at wk 5; and lameness and BCS at wk 7...
December 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29224858/a-resynchronization-of-ovulation-program-based-on-ovarian-structures-present-at-nonpregnancy-diagnosis-reduced-time-to-pregnancy-in-lactating-dairy-cows
#11
R Wijma, M M Pérez, M Masello, M L Stangaferro, J O Giordano
Our objective was to evaluate time to pregnancy after the first service postpartum and pregnancy per artificial insemination (P/AI) in dairy cows managed with 2 resynchronization of ovulation programs. After first service, lactating Holstein cows were blocked by parity (primiparous vs. multiparous) and randomly assigned to the d 32 Resynch (R32; n = 1,010) or short Resynch (SR; n = 1,000) treatments. Nonpregnancy diagnosis (NPD) was conducted 32 ± 3 d after AI by transrectal ultrasonography. Nonpregnant cows in R32 received the Ovsynch protocol: GnRH, PGF2α 7 d later, GnRH 56 h later, and timed AI (TAI) 16 to 18 h later...
December 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29223656/endometrial-expression-of-estrogen-and-progesterone-receptors-in-non-cyclic-mares-treated-only-with-long-acting-progesterone
#12
L F S Maciel, E S M Silva, J P Oliveira-Filho, S C Fritsch, R S Rossi, J A C Lourenção, C Meira
Administration of progesterone (P4) after estradiol is usually performed to prepare non-cyclic mares as embryo recipients. However, there are successful pregnancy reports after embryo transfer in non-cyclic mares treated only with progestins. The objective of this study was to evaluate endometrial gene expression and immunostaining for estrogen receptor alpha (ERα), beta (ERβ) and progesterone receptor (PR) in seasonal anestrous mares treated with long acting P4 (LA P4). Endometrial tissue from eight seasonal anestrous mares was collected immediately before administration of 1...
December 2, 2017: Theriogenology
https://www.readbyqxmd.com/read/29222540/validation-study-of-the-american-joint-committee-on-cancer-eighth-edition-prognostic-stage-compared-with-the-anatomic-stage-in-breast-cancer
#13
Anna Weiss, Mariana Chavez-MacGregor, Daphne Y Lichtensztajn, Min Yi, Audree Tadros, Gabriel N Hortobagyi, Sharon H Giordano, Kelly K Hunt, Elizabeth A Mittendorf
Importance: The American Joint Committee on Cancer (AJCC) eighth edition staging manual introduced a new prognostic stage for breast cancer incorporating biologic factors in addition to traditional anatomic factors. Objective: To perform a validation study of the AJCC eighth edition prognostic stage in a single-institution cohort and a large population database. Design, Setting, and Participants: Patients with breast cancer treated with surgery as an initial intervention were identified in a prospective institutional database from The University of Texas MD Anderson Cancer Center and the California Cancer Registry...
December 7, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29221432/sex-and-ethnic-racial-specific-risk-factors-for-gallbladder-disease
#14
Jane C Figueiredo, Christopher Haiman, Jacqueline Porcel, James Buxbaum, Daniel Stram, Neal Tambe, Wendy Cozen, Lynne Wilkens, Loic Le Marchand, Veronica Wendy Setiawan
BACKGROUND: Gallbladder disease (GBD) is a highly prevalent condition; however, little is known about potential differences in risk factors by sex and ethnicity/race. Our aim was to evaluate dietary, reproductive and obesity-related factors and GBD in multiethnic populations. METHODS: We performed a prospective analysis from the Multiethnic Cohort study who self-identified as non-Hispanic White (n = 32,103), African American (n = 30,209), Japanese (n = 35,987), Native Hawaiian (n = 6942) and Latino (n = 39,168)...
December 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29221114/interferon-%C3%AF-increases-bola-i-for-implantation-during-early-pregnancy-in-dairy-cows
#15
Zhe Zhu, Binbin Li, Yue Wu, Xiao Wang, GanZhen Deng
Interferon-τ (IFN-τ) signals pregnancy recognition in ruminants. We investigated the effects of IFN-τ produced by embryo trophoblastic cells (ETCs) on expression of bovine leukocyte antigen-I (BoLA-I), a bovine analogue of human MHC-I, in endometrial luminal epithelial cells (EECs) during early pregnancy in dairy cows. Expression of IFN-τ and BoLA-I was increased in endometrial tissues during early pregnancy. Expression of the anti-inflammatory cytokine IL-10 was increased in endometrial tissues, while expression of the pro-inflammatory cytokine IL-6 was decreased, indicating immunosuppression...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29217474/effect-of-particle-size-polydispersity-and-polymer-degradation-on-progesterone-release-from-plga-microparticles-experimental-and-mathematical-modeling
#16
Carlos Busatto, Juan Pesoa, Ignacio Helbling, Julio Luna, Diana Estenoz
Poly(lactic-co-glycolic acid) (PLGA) microparticles containing progesterone were prepared by the solvent extraction/evaporation and microfluidic techniques. Microparticles were characterized by their size distribution, encapsulation efficiency, morphology and thermal properties. The effect of particle size, polydispersity and polymer degradation on the in vitro release of the hormone was studied. A triphasic release profile was observed for larger microparticles, while smaller microspheres showed a biphasic release profile...
December 4, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29217458/imp2-and-imp3-cooperate-to-promote-the-metastasis-of-triple-negative-breast-cancer-through-destabilization-of-progesterone-receptor
#17
Hye-Youn Kim, Huyen Trang Ha Thi, Suntaek Hong
Triple-negative breast cancer (TNBC) is one of the most aggressive malignancies and is associated with high mortality rates due to the lack of effective therapeutic targets. In this study, we demonstrated that insulin-like growth factor-II mRNA-binding protein 2 and 3 (IMP2 and IMP3) are specifically overexpressed in TNBC and cooperate to promote cell migration and invasion. Downregulation of both IMP2 and IMP3 in TNBC cells was found to produce a synergistic effect in suppressing cell invasion and invadopodia formation, whereas overexpression of IMP2 and IMP3 in luminal subtype cells enhanced epithelial-mesenchymal transition and metastasis...
December 5, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29217167/potential-protective-effect-of-pistacia-lentiscus-oil-against-chlorpyrifos-induced-hormonal-changes-and-oxidative-damage-in-ovaries-and-thyroid-of-female-rats
#18
Samira Chebab, Fatiha Mekircha, Essaid Leghouchi
The purpose of this study was to evaluate the protective effect of Pistacia lentiscus oil (PLO), known for its antioxidant properties, on chlorpyrifos (CPF)-induced alterations in the thyroid, reproductive hormone levels, and oxidative damage in the ovaries and thyroid of adult Wistar rats. The animals were treated with orally administered PLO (2 mL/kg), CPF (6.75 mg/kg), and a combination of CPF and PLO for 30 days. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone (Pg), estradiol (E2), triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) were assessed using chemiluminescence assay...
December 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29216626/evidence-for-hmgn2-involvement-in-mouse-embryo-implantation-and-decidualization
#19
Dang-Dang Li, Liang Yue, Zhan-Qing Yang, Lian-Wen Zheng, Bin Guo
BACKGROUND/AIMS: Hmgn2 is involved in regulating embryonic development, but its physiological function during embryo implantation and decidualization remains unknown. METHODS: In situ hybridization, real-time PCR, RNA interference, gene overexpression and MTS assay were used to examine the expression of Hmgn2 in mouse uterus during the pre-implantation period and explore its function and regulatory mechanisms in epithelial adhesion junction and stromal cell proliferation and differentiation...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29216564/p27kip1-as-a-key-regulator-of-endometriosis
#20
REVIEW
G A Gonçalves
p27kip1 as a key regulator of endometriosis Gonçalves GA p27kip1 is a cyclin-dependent kinase (CDK) inhibitor whose specific late G1 destruction allows progression of the cell across the G1/S boundary. There is a direct relationship between low level of p27 and rapid proliferation occurring in several benign states and in many malignances. In the glandular cells of the normal endometrium, the level of p27kip1 is exceedingly low during the proliferative phase, whereas it is markedly increased during the secretory phase...
December 4, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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