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Keywords recurrent FSGS in kidney trans...

recurrent FSGS in kidney transplant

https://read.qxmd.com/read/38388144/anti-nephrin-antibodies-in-recurrence-of-focal-segmental-glomerulosclerosis-closer-to-discovering-the-holy-grail
#1
JOURNAL ARTICLE
Marina Vivarelli, Manuela Colucci
Recurrent forms of primary focal segmental glomerulosclerosis (FSGS) pose an unmet challenge to nephrologists, both in terms of understanding the underlying pathophysiology and in terms of identifying an effective management strategy of this disease, which frequently leads to kidney graft loss. In the past few decades, experimental observations both in patients and in animal models have led to the hypothesis of the existence of circulating factors driving the loss of integrity of the glomerular filtration barrier in FSGS...
March 2024: Kidney International
https://read.qxmd.com/read/38338714/what-is-hidden-in-patients-with-unknown-nephropathy-genetic-screening-could-be-the-missing-link-in-kidney-transplantation-diagnosis-and-management
#2
JOURNAL ARTICLE
Adele Mitrotti, Ighli Di Bari, Marica Giliberti, Rossana Franzin, Francesca Conserva, Anna Chiusolo, Maddalena Gigante, Matteo Accetturo, Cesira Cafiero, Luisa Ricciato, Emma Diletta Stea, Cinzia Forleo, Anna Gallone, Michele Rossini, Marco Fiorentino, Giuseppe Castellano, Paola Pontrelli, Loreto Gesualdo
Between 15-20% of patients with end stage renal disease (ESRD) do not know the cause of the primary kidney disease and can develop complications after kidney transplantation. We performed a genetic screening in 300 patients with kidney transplantation, or undiagnosed primary renal disease, in order to identify the primary disease cause and discriminate between overlapping phenotypes. We used a custom-made panel for next-generation sequencing (Agilent technology, Santa Clara, CA, USA), including genes associated with Fabry disease, podocytopaties, complement-mediated nephropathies and Alport syndrome-related diseases...
January 24, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38142038/post-transplant-recurrence-of-focal-segmental-glomerular-sclerosis-consensus-statements
#3
JOURNAL ARTICLE
Rupesh Raina, Swathi Jothi, Dieter Haffner, Michael Somers, Guido Filler, Prabhav Vasistha, Ronith Chakraborty, Ron Shapiro, Parmjeet S Randhawa, Rulan Parekh, Christopher Licht, Timothy Bunchman, Sidharth Sethi, Guneive Mangat, Joshua Zaritsky, Franz Schaefer, Bradley Warady, Sharon Bartosh, Mignon McCulloch, Khalid Alhasan, Agnieszka Swiatecka-Urban, William E Smoyer, Anil Chandraker, Hui Kim Yap, Vivekanand Jha, Arvind Bagga, Jai Radhakrishnan
Focal segmental glomerular sclerosis (FSGS) is 1 of the primary causes of nephrotic syndrome in both pediatric and adult patients, which can lead to end-stage kidney disease. Recurrence of FSGS after kidney transplantation significantly increases allograft loss, leading to morbidity and mortality. Currently, there are no consensus guidelines for identifying those patients who are at risk for recurrence or for the management of recurrent FSGS. Our work group performed a literature search on PubMed/Medline, Embase, and Cochrane, and recommendations were proposed and graded for strength of evidence...
December 22, 2023: Kidney International
https://read.qxmd.com/read/38110152/a-multi-institutional-study-found-a-possible-role-of-anti-nephrin-antibodies-in-post-transplant-focal-segmental-glomerulosclerosis-recurrence
#4
JOURNAL ARTICLE
Yoko Shirai, Kenichiro Miura, Kiyonobu Ishizuka, Taro Ando, Shoichiro Kanda, Junya Hashimoto, Yuko Hamasaki, Kiyohiko Hotta, Naoko Ito, Kazuho Honda, Kenji Tanabe, Tomoko Takano, Motoshi Hattori
Possible roles of anti-nephrin antibodies in post-transplant recurrent focal segmental glomerulosclerosis (FSGS) have been reported recently. To confirm these preliminary results, we performed a multi-institutional study of 22 Japanese pediatric kidney transplant recipients with FSGS including eight genetic FSGS and 14 non-genetic (presumed primary) FSGS. Eleven of the 14 non-genetic FSGS patients had post-transplant recurrent FSGS. Median (interquartile range) plasma levels of anti-nephrin antibodies in post-transplant recurrent FSGS measured using ELISA were markedly high at 899 (831, 1292) U/mL (cut-off 231 U/mL) before transplantation or during recurrence...
December 16, 2023: Kidney International
https://read.qxmd.com/read/38101474/efficacy-of-combined-rituximab-and-daratumumab-treatment-in-posttransplant-recurrent-focal-segmental-glomerulosclerosis
#5
Andrea Angeletti, Sofia Bin, Alberto Magnasco, Maurizio Bruschi, Paolo Cravedi, Gian Marco Ghiggeri
Focal segmental glomerulosclerosis (FSGS) is one of the leading causes of kidney failure and it is characterized by a high rate of recurrence after kidney transplant. Moreover, FSGS recurrence is worsened by an increased risk of graft failure. Common therapies for FSGS recurrence mostly consist of plasma exchange treatments, also for prolonged time, and rituximab, with variable efficacy. We report 5 cases of early FSGS recurrence after kidney transplant, resistant to plasma exchange and rituximab treatment that subsequently resolved after combined therapy with rituximab and daratumumab...
December 14, 2023: American Journal of Transplantation
https://read.qxmd.com/read/38008686/therapeutic-apheresis-in-renal-transplantation-an-update
#6
REVIEW
Christina Melexopoulou, Vassilis Filiopoulos, Smaragdi Marinaki
Therapeutic apheresis (TA) plays a significant role in various aspects of renal transplantation. It has been a necessary preconditioning component in ABO incompatible kidney transplants and an important modality in the removal of anti-human leukocyte antigen (HLA) antibodies both in the context of desensitization protocols that have been developed to allow highly sensitized kidney transplant candidates to be successfully transplanted and as treatment of antibody mediated rejection episodes post transplantation...
November 17, 2023: Transfusion and Apheresis Science
https://read.qxmd.com/read/37978039/therapeutic-apheresis-in-renal-transplantation-an-update
#7
REVIEW
Christina Melexopoulou, Vassilis Filiopoulos, Smaragdi Marinaki
Therapeutic apheresis (TA) plays a significant role in various aspects of renal transplantation. It has been a necessary preconditioning component in ABO incompatible kidney transplants and an important modality in the removal of anti-human leukocyte antigen (HLA) antibodies both in the context of desensitization protocols that have been developed to allow highly sensitized kidney transplant candidates to be successfully transplanted and as treatment of antibody mediated rejection episodes post transplantation...
November 3, 2023: Transfusion and Apheresis Science
https://read.qxmd.com/read/37921337/current-approaches-to-overcome-recurrent-focal-segmental-glomerulosclerosis-after-kidney-transplantation
#8
REVIEW
Syeda Behjat Ahmad, Yonatan Peleg, Wooin Ahn
PURPOSE OF REVIEW: Recurrent focal segmental glomerulosclerosis (FSGS) presents with nephrotic syndrome shortly after kidney transplantation. This review will overview the role of circulating permeability factors in disease pathogenesis and treatment options for recurrent FSGS. RECENT FINDINGS: Novel circulating permeability factors have been identified in serum samples. Current research is focused on detection of permeability factors as a marker of treatment response...
January 1, 2024: Current Opinion in Nephrology and Hypertension
https://read.qxmd.com/read/37917639/the-outcomes-of-patients-with-kidney-failure-due-to-focal-segmental-glomerulosclerosis-fsgs-in-australia-and-new-zealand-a-cohort-study-using-the-australia-and-new-zealand-dialysis-and-transplant-registry-anzdata
#9
JOURNAL ARTICLE
Bhadran Bose, Elasma Milanzi, Elaine M Pascoe, David W Johnson, Sunil V Badve
BACKGROUND: The outcomes of patients with focal segmental glomerulosclerosis (FSGS) on kidney replacement therapy (KRT) have not been well described. This study evaluated the outcomes of patients with kidney failure due to FSGS on KRT including dialysis and kidney transplantation. METHOD AND MATERIALS: All adult patients with kidney failure who commenced KRT in Australia and New Zealand from 15th of May 1963 to 31st of December 2018 were retrospectively extracted from the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry...
2023: PloS One
https://read.qxmd.com/read/37795085/current-understanding-of-the-molecular-mechanisms-of-circulating-permeability-factor-in-focal-segmental-glomerulosclerosis
#10
REVIEW
Giuseppe Salfi, Federica Casiraghi, Giuseppe Remuzzi
The pathogenetic mechanisms underlying the onset and the post-transplant recurrence of primary focal segmental glomerulosclerosis (FSGS) are complex and remain yet to be fully elucidated. However, a growing body of evidence emphasizes the pivotal role of the immune system in both initiating and perpetuating the disease. Extensive investigations, encompassing both experimental models and patient studies, have implicated T cells, B cells, and complement as crucial actors in the pathogenesis of primary FSGS, with various molecules being proposed as potential "circulating factors" contributing to the disease and its recurrence post kidney-transplantation...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37725070/incidence-risk-factors-and-outcomes-of-recurrent-focal-segmental-glomerulosclerosis-in-pediatric-kidney-transplant-recipients-a-systematic-review-and-meta-analysis
#11
REVIEW
Jiang Bai, Xinyu Yin, Jiaqi Li, Jia-Qi Li, Yanna Niu, Zhenhua Li, Jing Li, Yun Zhou
BACKGROUND: Focal segmental glomerulosclerosis is the most prevalent acquired kidney disease leading to end-stage renal disease in children and has a propensity for recurring in the transplanted kidney. The recurrence of FSGS after kidney transplantation in children varies greatly. In addition, the risk factors and outcomes of recurrence of FSGS remain controversial. This study evaluated the recurrence rate, risk factors, and prognosis of FSGS after kidney transplantation in order to provide advice and assistance in clinical decision-making for pediatric kidney transplantation...
November 2023: Clinical Transplantation
https://read.qxmd.com/read/37705972/biologics-in-steroid-resistant-nephrotic-syndrome-in-childhood-review-and-new-hypothesis-driven-treatment
#12
REVIEW
Andrea Angeletti, Maurizio Bruschi, Xhuliana Kajana, Edoardo La Porta, Sonia Spinelli, Gianluca Caridi, Francesca Lugani, Enrico Eugenio Verrina, Gian Marco Ghiggeri
Nephrotic syndrome affects about 2-7 per 100,000 children yearly and accounts for less than 15% of end stage kidney disease. Steroids still represent the cornerstone of therapy achieving remission in 75-90% of the cases The remaining part result as steroid resistant nephrotic syndrome, characterized by the elevated risk of developing end stage kidney disease and frequently presenting disease recurrence in case of kidney transplant. The pathogenesis of nephrotic syndrome is still far to be elucidated, however, efficacy of immune treatments provided the basis to suggest the involvement of the immune system in the pathogenesis of the disease...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37691539/clinical-course-of-post-kidney-transplant-schimke-immuno-osseous-dysplasia
#13
Hyun Ah Woo, Seong Heon Kim, Yo Han Ahn, Sang Il Min, Jongwon Ha, Il-Soo Ha, Hae Il Cheong, Hee Gyung Kang
BACKGROUND: Schimke immuno-osseous dysplasia (SIOD) is a rare systemic disease characterized by short stature, proteinuria, and recurrent infections. Patients usually have spondyloepiphyseal dysplasia, and progressive steroid-resistant nephropathy that leads to kidney failure. However, their clinical course after kidney transplantation (KT) is not yet well known. Here, we present our experience with cases of SIOD treated at our institute. CASE PRESENTATION: Since 2014, three children have been diagnosed with nephropathy resulting from SIOD...
September 11, 2023: Pediatric Transplantation
https://read.qxmd.com/read/37675355/a-randomized-controlled-trial-of-preemptive-rituximab-to-prevent-recurrent-focal-segmental-glomerulosclerosis-post-kidney-transplant-pri-vent-fsgs-protocol-and-study-design
#14
JOURNAL ARTICLE
Michelle N Rheault, Sandra Amaral, Margret Bock, Eileen Tsai Chambers, Blanche Chavers, Mireile El Ters, Rouba Garro, Rasheed Gbadegesin, Amit Govil, Lyndsay Harshman, Hatem Amer, David K Hooper, Ajay K Israni, Samy Riad, Junichiro Sageshima, Ron Shapiro, Michael Seifert, Jodi Smith, Randall Sung, Christie P Thomas, Qi Wang, Priya S Verghese
BACKGROUND: Focal segmental glomerulosclerosis (FSGS) is a common cause of end-stage kidney disease requiring kidney transplantation and can recur in the allograft in 30-80% of recipients resulting in reduced graft survival. Plasmapheresis has shown efficacy in treating some cases of recurrent FSGS but isolated plasmapheresis has not demonstrated efficacy in preventing recurrent FSGS. Rituximab has had anecdotal success in preventing recurrence in a single center study but has not been studied in combination with plasmapheresis for preventing FSGS recurrence...
2023: Front Nephrol
https://read.qxmd.com/read/37564655/the-podocyte-glomerular-sentinel-at-the-crossroads-of-innate-and-adaptive-immunity
#15
REVIEW
George W Burke, Alla Mitrofanova, Antonio Fontanella, Gaetano Ciancio, David Roth, Phil Ruiz, Carolyn Abitbol, Jayanthi Chandar, Sandra Merscher, Alessia Fornoni
Focal segmental glomerulosclerosis (FSGS) is a common glomerular disorder that manifests clinically with the nephrotic syndrome and has a propensity to recur following kidney transplantation. The pathophysiology and therapies available to treat FSGS currently remain elusive. Since the podocyte appears to be the target of apparent circulating factor(s) that lead to recurrence of proteinuria following kidney transplantation, this article is focused on the podocyte. In the context of kidney transplantation, the performance of pre- and post-reperfusion biopsies, and the establishment of in vitro podocyte liquid biopsies/assays allow for the development of clinically relevant studies of podocyte biology...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37404982/perturbations-in-podocyte-transcriptome-and-biological-pathways-induced-by-fsgs-associated-circulating-factors
#16
JOURNAL ARTICLE
Priyanka Rashmi, Tara K Sigdel, Dmitry Rychkov, Izabella Damm, Andrea Alice Da Silva, Flavio Vincenti, Andre L Lourenco, Charles S Craik, Jochen Reiser, Minnie M Sarwal
BACKGROUND: Focal segmental glomerulosclerosis (FSGS) is frequently associated with heavy proteinuria and progressive renal failure requiring dialysis or kidney transplantation. However, primary FSGS also has a ~40% risk of recurrence of disease in the transplanted kidney (rFSGS). Multiple circulating factors have been identified to contribute to the pathogenesis of primary and rFSGS including soluble urokinase-type plasminogen activator receptor (suPAR) and patient-derived CD40 autoantibody (CD40autoAb)...
June 30, 2023: Annals of Translational Medicine
https://read.qxmd.com/read/37277729/arteriovenous-fistula-in-a-renal-allograft-with-gross-hematuria-and-subsequent-acute-kidney-injury-due-to-urinary-tract-obstruction-a-case-report
#17
JOURNAL ARTICLE
Yujiro Aoki, Takeshi Kawamura, Nobuyuki Shiraga, Takashi Yonekura, Maho Maeda, Sota Kurihara, Yoshitaka Sekine, Seiichiro Shishido, Ken Sakai
BACKGROUND: Arteriovenous fistula (AVF) due to renal allograft biopsy is mechanical trauma resulting from the penetration of small arteries and veins by a core needle. Most AVFs are reported to resolve asymptomatically and spontaneously. This report presents a patient with acute kidney injury (AKI) due to urinary tract obstruction caused by a bleeding AVF in a renal allograft. CASE PRESENTATION: A 22-year-old Japanese woman who underwent living-donor kidney transplantation (KT) at 3 years due to end-stage renal disease caused by focal segmental glomerulosclerosis (FSGS) presented with a renal transplant AVF (gourd-shaped; 42 × 19 × 20 mm)...
June 5, 2023: BMC Nephrology
https://read.qxmd.com/read/37258049/early-recurrence-of-focal-segmental-glomerulosclerosis-in-a-kidney-transplant-recipient-with-apol1-one-risk-variant
#18
JOURNAL ARTICLE
Ratna Acharya, Kiran Upadhyay
Apolipoprotein 1 ( APOL1 ) risk variants (G1 and G2) are associated with focal segmental glomerulosclerosis (FSGS) in patients of African ancestry. The prevalence of APOL1 two risk variants is lower in Hispanics and very rare in European and Asian populations. APOL1 two risk variants in donor kidneys is associated with recipient kidney graft loss, however the effect of recipient risk variant in the kidney transplant outcome is unclear. Here, we present a late adolescent male with FSGS and end stage renal disease with one APOL1 risk variant (G2) who had immediate recurrence of FSGS in the post-KT period...
May 31, 2023: BMJ Case Reports
https://read.qxmd.com/read/37213488/living-donor-kidney-transplant-in-recipients-with-glomerulonephritis-donor-recipient-biologic-relationship-and-allograft-outcomes
#19
JOURNAL ARTICLE
Rasha El-Rifai, Adam Bregman, Nattawat Klomjit, Richard Spong, Scott Jackson, Patrick H Nachman, Samy Riad
Using the Scientific Registry of Transplant Recipients, we examined the association between donor-recipient biologic relationship and long-term recipient and allograft survival among glomerulonephritis (GN) patients. Four GN types were studied: membranous nephropathy, IgA, lupus-associated nephritis, and focal segmental glomerulosclerosis (FSGS). We identified all adult primary living-donor recipients between 2000 and 2018 ( n = 19,668): related ( n = 10,437); unrelated ( n = 9,231). Kaplan-Meier curves were generated for the recipient, death-censored graft survival and death with functioning graft through ten years post-transplant...
2023: Transplant International
https://read.qxmd.com/read/37085779/pathological-evaluation-of-renal-complications-in-children-following-allogeneic-hematopoietic-stem-cell-transplantation-a-retrospective-cohort-study
#20
JOURNAL ARTICLE
Ru-Yue Chen, Xiao-Zhong Li, Qiang Lin, Han-Yun Tang, Ning-Xun Cui, Lu Jiang, Xiao-Mei Dai, Wei-Qing Chen, Fan Deng, Shao-Yan Hu, Xue-Ming Zhu
BACKGROUND: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for hematologic malignancies and non-malignant disorders, such as aplastic anemia, fanconi anemia, and certain immune deficiencies. Post-transplantation kidney injury is a common complication and involves a wide spectrum of structural abnormalities, including glomerular (MSPGN, mesangial proliferative glomerulonephritis; FSGS, focal segmental glomerulosclerosis; MPGN, membranoproliferative glomerulonephritis; MCD, minimal change disease), vascular (TMA, thrombotic microangiopathy), and/or tubulointerstitial (TIN, tubulointerstitial nephritis; ATI, acute tubular injury)...
April 21, 2023: BMC Pediatrics
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