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https://www.readbyqxmd.com/read/28093680/the-international-diffuse-intrinsic-pontine-glioma-registry-an-infrastructure-to-accelerate-collaborative-research-for-an-orphan-disease
#1
Joshua Baugh, Ute Bartels, James Leach, Blaise Jones, Brooklyn Chaney, Katherine E Warren, Jenavieve Kirkendall, Renee Doughman, Cynthia Hawkins, Lili Miles, Christine Fuller, Tim Hassall, Eric Bouffet, Adam Lane, Darren Hargrave, Jacques Grill, Lindsey M Hoffman, Chris Jones, Alex Towbin, Sharon A Savage, Michelle Monje, Xiao-Nan Li, David S Ziegler, Sophie Veldhuijzen van Zanten, Christof M Kramm, Dannis G van Vuurden, Maryam Fouladi
Diffuse intrinsic pontine glioma (DIPG), a rare, often fatal childhood brain tumor, remains a major therapeutic challenge. In 2012, investigators, funded by the DIPG Collaborative (a philanthropic partnership among 29 private foundations), launched the International DIPG Registry (IDIPGR) to advance understanding of DIPG. Comprised of comprehensive deidentified but linked clinical, imaging, histopathological, and genomic repositories, the IDIPGR uses standardized case report forms for uniform data collection; serial imaging and histopathology are centrally reviewed by IDIPGR neuro-radiologists and neuro-pathologists, respectively...
January 16, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28007109/trypan-blue-as-a-surgical-adjunct-in-pediatric-cataract-surgery
#2
Gabrielle Fridman, Allison E Rizzuti, Jewel Liao, Mark Rolain, James A Deutsch, Stephen C Kaufman
PURPOSE: To study the effect of trypan blue on lens capsule elasticity and ease of completing a continuous curvilinear capsulorhexis (CCC) in a sheep lens model and to subsequently observe the effects of trypan blue in the surgical setting of 3 pediatric patients. SETTING: State University of New York, Downstate Medical Center, Brooklyn, New York, USA. DESIGN: Prospective case series. METHODS: Twenty-four lenses were excised from fresh sheep globes...
December 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28006894/evaluation-of-clinical-outcome-in-children-and-adolescents-receiving-vancomycin-for-invasive-infections-due-to-methicillin-resistant-staphylococcus-aureus-impact-of-increasing-vancomycin-mics
#3
Aparna Arun, Siddharth Swamy, Kathleen Jacob, Roopali Sharma, Stephan A Kohlhoff, Margaret R Hammerschlag
BACKGROUND: Vancomycin is the preferred drug for the treatment of MRSA infections in children. In adults, treatment failure with vancomycin has been associated with an area under the curve/24 hrs /MIC (AUC24/MIC) ratio of < 400 and high minimum inhibitory concentrations (MIC > 1.0 mg/L). Vancomycin dosing information to ensure optimal AUC24/MIC in the pediatric population remains limited. METHODS: A retrospective chart review from August 2008 to 2011 and a prospective study from September 2011 to October 2013 was conducted on all pediatric patients at two hospitals in Brooklyn, NY with positive cultures for MRSA who received vancomycin...
December 22, 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/28002704/interim-buprenorphine-vs-waiting-list-for-opioid-dependence
#4
RANDOMIZED CONTROLLED TRIAL
Stacey C Sigmon, Taylor A Ochalek, Andrew C Meyer, Bryce Hruska, Sarah H Heil, Gary J Badger, Gail Rose, John R Brooklyn, Robert P Schwartz, Brent A Moore, Stephen T Higgins
To the Editor: Opioid-use disorder has reached epidemic proportions, with high attendant costs in terms of increases in overdoses and infectious diseases and in economic costs. Despite the demonstrated efficacy of maintaining abstinence by treating patients with opioid agonists, patients can remain..
22, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/28002149/the-effect-of-allopurinol-on-renal-function
#5
Aneesa Krishnamurthy, Deana Lazaro, Dimitre G Stefanov, David Blumenthal, Donald Gerber, Sheetal Patel
BACKGROUND: Hyperuricemia is associated with development of gout, hypertension, and renal disease. The impact of allopurinol, a urate-lowering therapy, on renal function is unclear, especially in patients with chronic kidney disease who are at higher risk of hypersensitivity reaction. OBJECTIVES: The aim of this study was to determine the effect of allopurinol on kidney function in hyperuricemic male veterans. METHODS: This is a retrospective cohort study using pharmacy, medical, and laboratory records of veterans enrolled at the Veterans Administration New York Harbor Healthcare System, Brooklyn campus...
January 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27977065/experiences-of-patients-undergoing-dialysis-who-are-from-ethnic-and-racial-minorities
#6
Neha Nagpal, Carla Boutin-Foster, Jennifer Melendez, Patryk Kubiszeswki, Kamalani Uehara, Emanuela Offidani, Zenobia Faussett, Richie Chen, Cathy Redel, Clarence Waltrous, Barry Smith
BACKGROUND: Approximately 500,000 people in the United States are affected by end-stage kidney disease (ESKD), 53% of whom are Black or Latino. ESKD significantly impacts psychosocial health and quality of life. However, few studies address the psychosocial aspects of ESKD, especially among black and Latino adults. This study sought to understand the psychosocial context of living with ESKD among black and Latino adults who reside in a medically underserved community. STUDY DESIGN: A qualitative study...
December 15, 2016: Journal of Renal Care
https://www.readbyqxmd.com/read/27964925/who-really-manages-our-patients-medications-a-study-of-inner-city-adults-over-40-years-of-age
#7
Madhavi Gavini, Eve S Faber, Andrea Birnbaum, Richard Sadovsky
OBJECTIVES: Primarily to determine how many of our adult patients receive significant assistance from another individual with medication management. Secondarily, to determine if the number of prescribed medications can be predictors of whether the patient receives significant assistance with medication management. DESIGN: Cross-sectional survey study. SETTING: A level 3 patient-centered medical home family practice clinic in an inner city university hospital in Brooklyn, New York...
December 10, 2016: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/27904880/microbial-community-patterns-associated-with-automated-teller-machine-keypads-in-new-york-city
#8
Holly M Bik, Julia M Maritz, Albert Luong, Hakdong Shin, Maria Gloria Dominguez-Bello, Jane M Carlton
In densely populated urban environments, the distribution of microbes and the drivers of microbial community assemblages are not well understood. In sprawling metropolitan habitats, the "urban microbiome" may represent a mix of human-associated and environmental taxa. Here we carried out a baseline study of automated teller machine (ATM) keypads in New York City (NYC). Our goal was to describe the biodiversity and biogeography of both prokaryotic and eukaryotic microbes in an urban setting while assessing the potential source of microbial assemblages on ATM keypads...
November 2016: MSphere
https://www.readbyqxmd.com/read/27891369/the-diagnostic-value-of-urinalysis-in-hemodialysis-patients-with-fever-sepsis-or-suspected-urinary-tract-infection
#9
Katerina G Oikonomou, Adib Alhaddad
INTRODUCTION: The diagnostic validity of urinalysis in asymptomatic Hemodialysis (HD) patients is low and there is limited data on the diagnostic value of urinalysis in HD patients with fever, sepsis, or suspected Urinary Tract Infection (UTI). AIM: The aim of this study was to assess the sensitivity, specificity, positive and negative predictive value of pyuria, bacteriuria, Leukocyte Esterase (LE) and nitrite positivity in symptomatic, febrile or/and septic HD patients...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27875073/orthodox-jewish-thought-leaders-insights-regarding-brca-mutations-a-descriptive-study
#10
Toby Bressler, Beth Popp
PURPOSE: To examine the factors that influence Orthodox Jewish (OJ) thought leaders' perceptions of genetic counseling and testing for BRCA mutations. The specific aims of this study were to describe (1) OJ thought leaders' views on genetic counseling and testing for BRCA mutation status and (2) insights into this high-risk faith-based minority group and their beliefs about counseling and testing for BRCA mutations. METHODS: In-depth focus groups and demographic questionnaires were used in this descriptive, qualitative study, which was performed in the cancer center of a 750-bed community teaching hospital in Brooklyn, New York...
November 22, 2016: Journal of Oncology Practice
https://www.readbyqxmd.com/read/27854525/effectiveness-of-local-policy-efforts-to-increase-the-price-of-cheap-cigars-in-minnesota
#11
Betsy Brock, Samantha C Carlson, Molly Moilanen, Barbara A Schillo
OBJECTIVES: To evaluate the effect of novel policies designed to increase cheap cigar prices by setting minimum prices at the local level. METHODS: Between June 2013 and July 2015, we conducted assessments at tobacco retailers in Minnesota cities of Brooklyn Center (n = 26 in sample; n = 18 assessed before and after policy implementation), Saint Paul (n = 25 in sample; n = 14 assessed pre- and postpolicy), and Maplewood (n = 22 in sample; n = 18 assessed pre- and postpolicy), before and after the adoption of policies setting minimum cigar pricing...
January 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/27815795/charles-william-lacaillade-biologist-parasitologist-educator-and-mentor
#12
Pascal James Imperato
Charles William Lacaillade (1904-1978) was an eminent biologist in the middle decades of the twentieth century. He was born in Lawrence, Massachusetts of parents whose ancestors were French Canadians. His father, also named Charles William Lacaillade, was a dentist who graduated from Tufts University School of Dentistry in 1898. His mother, Elodia Eno, came from a family of very successful businessmen. Lacaillade was the third of six children. His two older brothers, Harold Carleton and Hector Eno, both graduated from the University of Louisville, School of Dentistry, while his younger brother, Lawrence, became a businessman...
November 5, 2016: Journal of Community Health
https://www.readbyqxmd.com/read/27696535/community-unemployment-and-disaster-related-stressors-shape-risk-for-posttraumatic-stress-in-the-longer-term-aftermath-of-hurricane-sandy
#13
Sarah R Lowe, Laura Sampson, Oliver Gruebner, Sandro Galea
Persons living in communities with limited resources are at heightened risk of posttraumatic stress (PTS) after disasters, especially if they were highly exposed. The support deterrence desistence model and the conservation of resources theory suggest that this risk might increase in the longer-term aftermath of disasters. In the present study, we aimed to test this hypothesis. Two population-based samples of New York City residents in communities affected by Hurricane Sandy were surveyed at either 13-16 months (Time 1; n = 421) or 25-28 months (Time 2; n = 420) postdisaster...
October 2016: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/27636875/impact-of-a-pharmacist-initiated-vancomycin-monitoring-program
#14
Andrew P Smith, Catherine A Millares-Sipin, Marian James, Henry Cohen
OBJECTIVES: Evaluate the clinical impact of pharmacist-initiated vancomycin monitoring and dosing in a long-term care setting. DESIGN: Single-center, pretest, post-test design. SETTING: Rutland Nursing Home, Brooklyn, New York. PARTICIPANTS: Nursing facility residents treated with intravenous vancomycin (N = 198). OUTCOME MEASURES: The primary objective is to determine the incidence of acute kidney injury (AKI) a year before and a year after implementation of a pharmacist-initiated vancomycin-monitoring protocol...
September 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/27536467/leptin-adiponectin-and-cognition-in-middle-aged-hiv-infected-and-uninfected-women-the-brooklyn-women-s-interagency-hiv-study
#15
Deborah R Gustafson, Michelle M Mielke, Sheila A Keating, Susan Holman, Howard Minkoff, Howard A Crystal
CONTEXT: Case-control study of women with and without HIV infection. OBJECTIVE: To explore the association of cognition and the adipokines, leptin and adiponectin (total; high molecular weight, HMW), in women with (HIV+) and without HIV (HIV-) infection. DESIGN: Cross-sectional analyses of adipokines and cognition using linear regression models of log-transformed adipokines, and Trails A, Trails B, Stroop interference time, Stroop word recall, Stroop color naming and reading, and Symbol Digit Modalities Test (SDMT) with consideration for age, HIV infection status, education, CD4 count, diabetes, body mass index (BMI), waist circumference (WC) and race/ethnicity...
October 2015: Journal of Gerontology & Geriatric Research
https://www.readbyqxmd.com/read/27436388/administration-of-a-survey-to-evaluate-the-attitudes-of-house-staff-physicians-towards-antimicrobial-resistance-and-the-antimicrobial-stewardship-programme-at-a-community-teaching-hospital
#16
Veena Venugopalan, Nathan Trustman, Nyla Manning, Nehal Hashem, Leonard Berkowitz, Levita Hidayat
Antimicrobial stewardship programmes (ASPs) are used in numerous institutions in an effort to promote safe and effective antimicrobial use. The objectives of this study were to (i) assess physicians' perceptions, attitudes and knowledge about antimicrobial use, resistance and the ASP at The Brooklyn Hospital Center (TBHC) and (ii) measure physicians' beliefs and attitudes to the current system of prior authorisation of antimicrobials. A 75-item, anonymous, voluntary, traditional paper and pencil survey was distributed to resident physicians at TBHC...
March 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27404065/our-health-is-in-our-hands-a-social-marketing-campaign-to-combat-obesity-and-diabetes
#17
Kimberly S George, Calpurnyia B Roberts, Stephen Beasley, Margaretta Fox, Kweli Rashied-Henry
PURPOSE: Design, implement, and evaluate a 6-week social marketing campaign (SMC) to raise awareness of obesity and increase involvement in type 2 diabetes prevention, nutrition, and fitness programs offered by the Brooklyn Partnership to Drive Down Diabetes (BP3D) in two low-income, urban communities. DESIGN: This was a nonexperimental, formative research, mixed-methods study. SETTING: The study took place in Central Brooklyn and East New York, two of the most impoverished, high-need communities in New York City...
March 2016: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/27239309/improving-the-laboratory-add-on-process-and-increasing-housestaff-satisfaction-with-an-emr-intervention
#18
Vahe Shahnazarian, Parag Mehta
At a community hospital in Brooklyn, New York, the process for ordering add-on testing to drawn blood tubes involved filling out a paper sheet, then faxing and bulleting that sheet to the lab. It was a very inefficient, cumbersome, and unsatisfactory way of completing the process. In light of this, an EMR intervention was implemented in which the add-on order was placed as an EMR order. The study spanned over almost five years, over a year of which was post-intervention. There was a statistically significant increase in the number of add-on orders being placed as a result of the intervention...
2016: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/27220853/public-health-concerns-associated-with-the-new-york-city-blackout-of-1977
#19
Pascal James Imperato
The 1977 New York City blackout began at 9:36 p.m. on 13 July and lasted some 25 h until 10:39 p.m. on 14 July. The New York City Department of Health rapidly set up a Blackout Contingency Plan, established priorities, and mobilized its staff to address remedial interventions. Top priorities included water supplies, sewage disposal, perishable food supplies, hospital and emergency room services, solid waste disposal, beach contamination with untreated sewage , and assisting those on electrically powered home life support systems...
August 2016: Journal of Community Health
https://www.readbyqxmd.com/read/27159566/high-society-framing-the-brooklyn-eagle-and-the-popularity-of-twilight-sleep-in-brooklyn
#20
Bethany Johnson, Margaret M Quinlan
Twilight Sleep (TS) is an obstetric intervention during which a laboring woman enters a semiconscious state via injection. TS received enthusiastic support in Brooklyn, NY, in The Brooklyn Eagle (TBE) newspaper between 1914 and 1918. The purpose of this article is to analyze the framing of TS in TBE as the most popular obstetric intervention among wealthy, White socialites in Brooklyn during the period. The coverage in TBE prompted a nearly universally positive perception of TS among the newspaper's wider readership...
January 2017: Health Communication
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