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https://www.readbyqxmd.com/read/29674033/analytical-method-validation-to-evaluate-dithiocarbamates-degradation-in-biobeds-in-south-of-brazil
#1
Catiucia S Vareli, Ionara R Pizzutti, Luciano Gebler, Carmem D Cardoso, Daniela S H Gai, Marlos E Z Fontana
In order to evaluate the efficiency of biobeds on DTC degradation, the aim of this study was to apply, optimize and validate a method to determine dithiocarbamate (mancozeb) in biobeds using gas chromatography-tandem mass spectrometry (GC-MS). The DTC pesticide mancozeb was hydrolysed in a tin (II) chloride solution at 1.5% in HCl (4 mol L-1 ), during 1 h in a water bath at 80 °C, and the CS2 formed was extracted in isooctane. After cooling, 1 mL of the organic layer was transferred to an auto sampler vial and analyzed by GC-MS...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29667113/lack-of-association-between-obesity-and-aggressiveness-of-differentiated-thyroid-cancer
#2
G Grani, L Lamartina, T Montesano, G Ronga, V Maggisano, R Falcone, V Ramundo, L Giacomelli, C Durante, D Russo, M Maranghi
PURPOSE: Aim of this study was to evaluate the association between body mass index (BMI) and aggressive features of differentiated thyroid cancer (DTC) in a prospective cohort. METHODS: Patients with DTC were prospectively enrolled at a tertiary referral center and grouped according to their BMI. Aggressive clinic-pathological features were analyzed following the American Thyroid Association Initial Risk Stratification System score. RESULTS: The cohort was composed of 432 patients: 5 (1...
April 17, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29665748/low-or-undetectable-basal-thyroglobulin-levels-obviate-the-need-for-neck-ultrasound-in-differentiated-thyroid-cancer-patients-after-total-thyroidectomy-and-i-131-ablation
#3
Frederik Verburg, Uwe Maeder, Luca Giovanella, Markus Luster, Christoph Reiners
BACKGROUND: Neck ultrasound (NUS) is currently seen as a main component of follow-up of differentiated thyroid cancer (DTC) and is usually performed regardless of non-stimulated thyroglobulin (Tg) levels. The aim of this study is to determine whether there is a clinical benefit from such a routine NUS in DTC patients. METHODS: We performed a retrospective database study of 3176 cervical ultrasound exams performed in 773 patients between June 15, 1996 and July 1, 2012...
April 18, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29663333/prognostic-significance-of-gross-extrathyroidal-extension-invading-only-strap-muscles-in-differentiated-thyroid-carcinoma
#4
S Y Park, H I Kim, J-H Kim, J S Kim, Y L Oh, S W Kim, J H Chung, H W Jang, T H Kim
BACKGROUND: In the eighth edition of the AJCC staging system for differentiated thyroid carcinoma (DTC), minimal extrathyroidal extension (ETE) is no longer a determinant of T3 category. Instead, gross ETE invading only strap muscles has been designated as a new T3b category. The long-term prognosis of patients with DTC and gross ETE invading only strap muscles was investigated. METHODS: This was a retrospective analysis of patients who underwent thyroidectomy between 1996 and 2005...
April 17, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29662562/the-predictive-values-of-lesion-size-f-18-fdg-avidity-and-i-131-avidity-for-the-clinical-outcome-of-i-131-treatment-in-patients-with-metastatic-differentiated-thyroid-carcinoma-only-in-the-lung
#5
Joon Ho Choi, Byung Hyun Byun, Ilhan Lim, Hansol Moon, Jihyun Park, Kyoung Jin Chang, Byung Il Kim, Chang Woon Choi, Sang Moo Lim
Purpose: We aimed to evaluate the prognostic values of radiography, F-18 FDG PET, and I-131 whole body scans in patients with lung-only metastasis from differentiated thyroid carcinoma (DTC). Methods: Between 1998 and 2013, we included 31 patients (F: 26, M: 5) with lung-only metastasis from DTC who had been treated with I-131 and underwent PET. Lung metastasis was categorized according to the size (macronodular ≥1.0 cm vs. micronodular <1.0 cm), FDG avidity (avid vs...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29659694/nutritional-genomics-and-direct-to-consumer-genetic-testing-an-overview
#6
Marta Guasch-Ferré, Hassan S Dashti, Jordi Merino
The increasing prevalence in polygenic diseases, such as obesity, cardiovascular disease, and type 2 diabetes, observed over the past few decades is more likely linked to a rapid transition in lifestyle rather than to changes in the sequence of the nuclear genome. In the new era of precision medicine, nutritional genomics holds the promise to be translated into tailored nutritional strategies to prevent and manage polygenic diseases more effectively. Nutritional genomics aims to prevent, treat, and manage polygenic diseases through targeted therapies formulated from individuals' genetic makeup and dietary intake...
March 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29656442/treatment-emergent-hypertension-and-efficacy-in-the-phase-3-study-of-e7080-lenvatinib-in-differentiated-cancer-of-the-thyroid-select
#7
Lori J Wirth, Makoto Tahara, Bruce Robinson, Sanjeev Francis, Marcia S Brose, Mouhammed Amir Habra, Kate Newbold, Naomi Kiyota, Corina E Dutcus, Elton Mathias, Matthew Guo, Steven I Sherman, Martin Schlumberger
BACKGROUND: Hypertension (HTN) is an established class effect of vascular endothelial growth factor receptor (VEGFR) inhibition. In the phase 3 Study of (E7080) Lenvatinib in Differentiated Cancer of the Thyroid (SELECT) trial, HTN was the most frequent adverse event of lenvatinib, an inhibitor of VEGFR1, VEGFR2, VEGFR3, fibroblast growth factor receptor 1 (FGFR1), FGFR2, FGFR3, FGFR4, platelet-derived growth factor receptor α (PDGFRα), ret proto-oncogene (RET), and stem cell factor receptor (KIT)...
April 14, 2018: Cancer
https://www.readbyqxmd.com/read/29652050/long-term-c-elegans-immobilization-enables-high-resolution-developmental-studies-in-vivo
#8
Simon Berger, Evelyn Lattmann, Tinri Aegerter-Wilmsen, Michael Hengartner, Alex Hajnal, Andrew deMello, Xavier Casadevall I Solvas
Live-imaging of C. elegans is essential for the study of conserved cellular pathways (e.g. EGFR/Wnt signaling) and morphogenesis in vivo. However, the usefulness of live imaging as a research tool has been severely limited by the need to immobilize worms prior to and during imaging. Conventionally, immobilization is achieved by employing both physical and chemical interventions. These are known to significantly affect many physiological processes, and thus limit our understanding of dynamic developmental processes...
April 13, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29650270/radioiodine-refractory-differentiated-thyroid-cancer
#9
REVIEW
Yuchen Jin, Douglas Van Nostrand, Lingxiao Cheng, Min Liu, Libo Chen
Differentiated thyroid cancer (DTC) is usually curable with surgery, radioactive iodine (RAI), and thyroid-stimulating hormone (TSH) suppression. However, local recurrence and/or distant metastases occur in approximately 15% of cases during follow-up, and nearly two-thirds of these patients will become RAI-refractory (RR-DTC) with a poor prognosis. This review focuses on the most challenging and rapidly evolving aspects of RR-DTC, and we discuss the considerable improvement in more accurately defining RR-DTC, more effective therapeutic strategies, and describe the diagnosis, pathogenesis, and future prospects of RR-DTC...
May 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29644472/pictorial-representation-of-illness-and-self-measure-revised-2-prism-r2-an-effective-tool-to-assess-perceived-burden-of-thyroid-cancer-in-mainland-china
#10
Yanbo Wang, Suyun Fan, Hongbiao Wang, Li Li, Yanyan Jia, Li Chai
PURPOSE: Thyroid cancer, especially differentiated thyroid cancer (DTC), is a highly prevalent chronic disease that is known to cause considerable distress, related both to the high recurrence and treatment of the disease. The Pictorial Representation of Illness and Self Measure-Revised 2 (PRISM-R2) has been developed as a visual measure to assess suffering. The aim of this study was to evaluate the ability of the instrument to identify patients with DTC with different levels of suffering who may need additional support care...
April 11, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29643667/role-of-preablative-stimulated-thyroglobulin-in-prediction-of-nodal-and-distant-metastasis-on-iodine-whole-body-scan
#11
Meghana Prabhu, Sanju Samson, Avinash Reddy, Sunil Hejaji Venkataramanarao, Naveen Hedne Chandrasekhar, Vijay Pillai, Vivek Shetty, Moni Abraham Koriokose, Bushan Vaidhya, Subramanian Kannan
Background: Preablative stimulated thyroglobulin (ps-Tg) is an important investigation in the follow-up of patients with Differentiated thyroid cancer(DTC) after surgery. Levels of ps-Tg >2-10 ng/ml have been suggested to predict metastasis to cervical and extracervical sites. There is still debate on the need for routine iodine whole-body scan (131 I WBS) in the management of low-to-intermediate-risk DTC patients. Objective: We analyzed our data of patients with DTC who underwent total thyroidectomy to discuss the predictability of ps-Tg on metastatic disease on the 131 I WBS...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29628632/expression-of-bax-and-bcl2-genes-in-peripheral-blood-lymphocytes-of-patients-with-differentiated-thyroid-cancer
#12
Zari Hamivand, Gholamhassan Haddadi, Reza Fardid
Context: Thyroid cancer is the most common endocrine malignancy worldwide. Iodine-131 is used in the treatment of thyroid cancer with dosage of 100 mCi. In the medical applications of ionizing radiation besides the advantages such as diagnosis and treatment of diseases, the risks arising from exposure should be considered as well. Aims: The present study aimed to evaluate the changes in expression levels of apoptotic Bax and Bcl-2 and the ratio of Bax/Bcl-2, in the peripheral blood lymphocytes (PBLs) of patients with differentiated thyroid cancer (DTC)...
January 2018: Journal of Medical Physics
https://www.readbyqxmd.com/read/29626613/comparing-the-effects-of-dual-task-gait-testing-in-new-and-established-ambulators-with-lower-extremity-amputations
#13
Courtney Frengopoulos, Michael Wc Payne, Jeffrey D Holmes, Ricardo Viana, Susan W Hunter
BACKGROUND: Gait is a complex process that involves coordinating motor and sensory systems through higher-order cognitive processes. Walking with a prosthesis after lower extremity amputation challenges these processes. However, the factors that influence the cognitive-motor interaction in gait among lower extremity amputees has not been evaluated. To assess the interaction of cognition and mobility, individuals must be evaluated using the dual-task paradigm. OBJECTIVE: To investigate the effect of etiology and time with prosthesis on dual-task performance in those with lower extremity amputations...
April 4, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29620964/prognostic-implication-of-n1b-classification-in-the-eighth-edition-of-the-tumor-node-metastasis-staging-system-of-differentiated-thyroid-cancer
#14
Mijin Kim, Min Ji Jeon, Hye-Seon Oh, Suyeon Park, Dong Eun Song, Tae-Yon Sung, Tae Yong Kim, Ki-Wook Chung, Won Bae Kim, Young Kee Shong, Yu-Mi Lee, Won Gu Kim
BACKGROUND: Regional lymph node metastases (LNM) have prognostic significance in differentiated thyroid cancer (DTC). However, there was no distinction between N1a and N1b in the final staging classification in the eighth edition of the tumor-node-metastasis (TNM) staging system. This study aimed to evaluate the prognostic implication of N1b classification for predicting disease-specific survival (DSS) in DTC patients with stage I/II disease. METHODS: A total of 3089 patients with stage I/II DTC who underwent thyroid surgery between 1996 and 2005 were included...
April 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29619749/decreased-staging-of-differentiated-thyroid-cancer-in-patients-with-chronic-lymphocytic-thyroiditis
#15
M Borowczyk, A Janicki, G Dworacki, E Szczepanek-Parulska, M Danieluk, J Barnett, M Antonik, M Kałużna, B Bromińska, R Czepczyński, M Bączyk, K Ziemnicka, M Ruchała
PURPOSE: The biological association between chronic lymphocytic thyroiditis (CLT) and differentiated thyroid cancer (DTC) has not been elucidated yet. The aim of the study was to assess whether the presence of CLT exerts any influence on clinical or histological presentation of DTC. METHODS: Nine hundred and seven consecutive patients with DTC treated in the years 1998-2016 were divided into two groups according to the presence or absence of concomitant CLT. The statistical differences were analysed...
April 4, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29618578/pet-response-assessment-in-apatinib-treated-radioactive-iodine-refractory-thyroid-cancer
#16
Chen Wang, Xin Zhang, Xue Yang, Hui Li, Ruixue Cui, Wenmin Guan, Xin Li, Zhaohui Zhu, Yansong Lin
This work evaluated the use of the positron emission tomography/computed tomography (PET/CT) technique to assess the early therapeutic response and predict the prognosis of patients with radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC) who underwent apatinib therapy. Standardised uptake value (SUV), metabolic tumour volume (MTV) and total lesion glycolysis (TLG), derived from 18FDG PET/CT and SUV from 68Ga-NOTA-PRGD2 PET/CT, were evaluated. Tumour response was evaluated using the Response Evaluation Criteria in Solid Tumors (RECIST) 1...
April 4, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29616133/mismatch-repair-single-nucleotide-polymorphisms-and-thyroid-cancer-susceptibility
#17
Luís S Santos, Susana N Silva, Octávia M Gil, Teresa C Ferreira, Edward Limbert, José Rueff
Thyroid cancer (TC) is the most common endocrine malignancy and its incidence continues to rise worldwide. Ionizing radiation exposure is the best established etiological factor. Heritability is high; however, despite valuable contribution from recent genome-wide association studies, the current understanding of genetic susceptibility to TC remains limited. Several studies suggest that altered function or expression of the DNA mismatch repair (MMR) system may contribute to TC pathogenesis. Therefore, the present study aimed to evaluate the potential role of a panel of MMR single nucleotide polymorphisms (SNPs) on the individual susceptibility to well-differentiated TC (DTC)...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29615115/effectiveness-of-personal-genomic-testing-for-disease-prevention-behavior-when-combined-with-careful-consultation-with-a-physician-a-preliminary-study
#18
Mikihiro Hayashi, Atai Watanabe, Masaaki Muramatsu, Naohide Yamashita
OBJECTIVES: There are many direct-to-consumer (DTC)-type personal genomic testing (PGT) services commercially available to the public, providing the specific disease susceptibilities of individuals. While these services do not appear to stimulate disease-prevention behavior, few studies have addressed the methods to do so. We investigated the effectiveness of combining a consultation with a physician with the delivery of test results from a DTC-type PGT, as a preliminary study to identify the effective genomic testing for disease-prevention...
April 3, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29608901/improving-dual-task-control-with-a-posture-second-strategy-in-early-stage-parkinson-s-disease
#19
Cheng-Ya Huang, Yu-An Chen, Ing-Shiou Hwang, Ruey-Meei Wu
OBJECTIVE: To examine the task prioritization effects on postural-suprapostural dual task performance in patients with early-stage Parkinson's disease (PD) without clinical observed postural symptoms. DESIGN: Cross-sectional study. Participants performed a force-matching task while standing on a mobile-platform, and were instructed to focus their attention on either the postural task (posture-first strategy) or the force-matching task (posture-second strategy). SETTING: University research laboratory...
March 30, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29594057/thyroid-cancer-induction-nitrates-as-independent-risk-factors-or-risk-modulators-after-radiation-exposure-with-a-focus-on-the-chernobyl-accident
#20
REVIEW
Valentina M Drozd, Igor Branovan, Nikolay Shiglik, Johannes Biko, Christoph Reiners
In recent decades, differentiated thyroid cancer (DTC) incidence has been increasing worldwide. The important contributions to this phenomenon of "overdiagnosis" driven by wider use of improved ultrasound systems are amply documented, notwithstanding the "real" carcinogenic effects of ionizing radiation, e.g., from the Chernobyl accident or health care interventions. Less well understood is the role of nitrates - as environmental pollutants, in diet, and in medication - in thyroid carcinogenesis...
March 2018: European Thyroid Journal
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