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https://www.readbyqxmd.com/read/28715713/metastasis-systems-biology-how-are-macro-environmental-signals-transmitted-into-microenvironmental-cues-for-disseminated-tumor-cells
#1
REVIEW
Candice Alexandra Grzelak, Cyrus Michael Ghajar
Disseminated breast tumor cells reside on or near stable microvascular endothelium. Currently, the cues that disrupt DTC dormancy and facilitate outgrowth are largely unknown. This article explores the hypothesis that specific patient lifestyle exposures (e.g., alcohol abuse) may disrupt the microenvironments that maintain disseminated tumor cell (DTC) dormancy in a tissue-specific fashion. We suggest that such exposures are 'transmitted' to the dormant niche in the form of injury. Thus, we discuss the relationship between wound healing and metastasis using liver as an example to illustrate how injury steers the phenotype of liver endothelium and perivascular hepatic stellate cells to a potentially pro-metastatic one...
July 14, 2017: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/28713696/bilateral-axillo-breast-approach-robotic-thyroidectomy-review-of-evidences
#2
REVIEW
Shirley Yuk-Wah Liu, Jee Soo Kim
The bilateral axillo-breast approach (BABA) is one of the most popular contemporary remote-access thyroidectomy techniques. While the initial experiences with BABA endoscopic thyroidectomy (ET) were associated with some technical challenges and safety concerns, many limitations of the technique could now be substantially overcome by BABA robotic thyroidectomy (RT). In this review, the current literature evidences of BABA RT were analyzed. Data regarding the patient selection, the learning curve, and the comparison with open thyroidectomy (OT) and BABA ET were examined...
June 2017: Gland Surgery
https://www.readbyqxmd.com/read/28710714/disseminated-tumor-cells-are-not-associated-with-established-risk-factors-l1cam-immunoreactivity-and-outcome-in-endometrial-carcinoma
#3
Stefan Kommoss, Andreas D Hartkopf, Bernhard Krämer, Anne-Kathrin Bunz, Friederike Grevenkamp, Felix Kommoss, Jana Pasternak, Sabine M Arbabi, Markus Wallwiener, Annette Staebler, Sigurd F Lax, Sara Y Brucker, Florin-Andrei Taran
PURPOSE: The presence of disseminated tumor cells (DTC) in the bone marrow of endometrial carcinoma patients has been demonstrated previously. In contrast to breast cancer, no prognostic significance or association with clinicopathological features was revealed for endometrial carcinoma so far. The aim of this study was to investigate DTC in a large patient cohort with in-depth pathology review data available and to study DTC occurrence in the context of L1CAM and long-term disease specific follow-up...
July 14, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28704837/hamburg-glasgow-classification-preoperative-staging-by-combination-of-disseminated-tumour-load-and-systemic-inflammation-in-oesophageal-carcinoma
#4
Matthias Reeh, Tarik Ghadban, Faik G Uzunoglu, Michael F Nentwich, Maximilian Bockhorn, Klaus Pantel, Jakob R Izbicki, Yogesh K Vashist
BACKGROUND: The aim of this study was to establish a new preoperative staging classification and evaluate its comparability to the post-operative tumour stage, lymph node invasion and metastasis (TNM) classification. To date, adequate, preoperative staging in patients with oesophageal carcinoma (EC) is still missing but urgently needed. Systemic inflammation and disseminated tumour load have a pivotal role in recurrence and oncological outcome. To improve the clinical staging, we merged the Glasgow Prognostic Score (GPS) and disseminated tumour cells (DTC) into a new sufficient preoperative staging classification, the Hamburg-Glasgow classification (HGC)...
July 13, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28704384/quantitative-thyroglobulin-response-to-radioactive-iodine-treatment-in-predicting-radioactive-iodine-refractory-thyroid-cancer-with-pulmonary-metastasis
#5
Chen Wang, Xin Zhang, Hui Li, Xin Li, Yansong Lin
OBJECTIVE: Current diagnosis of radioactive iodine (RAI)-refractory (RAIR) differentiated thyroid cancer (DTC) is based on the imaging technique, which is of a high cost. Serum thyroglobulin (Tg) is a sensitive and easily obtained biomarker. Hence, we aimed to assess the predicting value of quantitative response of Tg in earlier identifying the RAIR-DTC with pulmonary metastasis. PATIENTS AND METHODS: Pulmonary metastatic DTC patients who underwent total or near-total thyroidectomy and at least two times of RAI therapy were included in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28704099/long-term-outcomes-and-prognostic-factors-in-patients-with-differentiated-thyroid-cancer-and-distant-metastases
#6
Dania Hirsch, Sigal Levy, Gloria Tsvetov, Alexander Gorstein, Ilana Slutzky-Shraga, Amit Akirov, Eyal Robenshtok, Ilan Shimon, Carlos A Benbassat
OBJECTIVE: Distant metastatic spread is the most frequent cause of thyroid cancer-related death. The objective of this study was to evaluate overall and disease-related survival of patients with differentiated thyroid cancer (DTC) and distant metastases (DM) attending a single medical center and to investigate variables predictive of better long-term outcomes. METHODS: The Rabin Medical Center Thyroid Cancer Registry was searched for patients with DM from DTC. RESULTS: The cohort included 138 patients (58...
July 13, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28703222/transparency-of-genetic-testing-services-for-health-wellness-and-lifestyle-analysis-of-online-prepurchase-information-for-uk-consumers
#7
Jacqueline A Hall, Rena Gertz, Joan Amato, Claudia Pagliari
The declining cost of DNA sequencing has been accompanied by a proliferation of companies selling 'direct-to-consumer genetic testing' (DTC-GT) services. Many of these are marketed online as tools for enabling citizens to make more informed decisions about their health, wellness and lifestyle. We assessed the 'information for consumers' provided by these companies at the prepurchase stage, which could influence initial decisions to part with money, data or tissue samples. A scoping exercise revealed 65 DTC-GT companies advertising their services online to consumers in the United Kingdom, of which 15 met our inclusion criteria...
August 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28703219/genome-wide-association-and-expression-quantitative-trait-loci-studies-identify-multiple-susceptibility-loci-for-thyroid-cancer
#8
Ho-Young Son, Yul Hwangbo, Seong-Keun Yoo, Sun-Wha Im, San Duk Yang, Soo-Jung Kwak, Min Seon Park, Soo Heon Kwak, Sun Wook Cho, Jun Sun Ryu, Jeongseon Kim, Yuh-Seog Jung, Tae Hyun Kim, Su-Jin Kim, Kyu Eun Lee, Do Joon Park, Nam Han Cho, Joohon Sung, Jeong-Sun Seo, Eun Kyung Lee, Young Joo Park, Jong-Il Kim
Thyroid cancer is the most common cancer in Korea. Several susceptibility loci of differentiated thyroid cancer (DTC) were identified by previous genome-wide association studies (GWASs) in Europeans only. Here we conducted a GWAS and a replication study in Koreans using a total of 1,085 DTC cases and 8,884 controls, and validated these results using expression quantitative trait loci (eQTL) analysis and clinical phenotypes. The most robust associations were observed in the NRG1 gene (rs6996585, P=1.08 × 10(-10)) and this SNP was also associated with NRG1 expression in thyroid tissues...
July 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28699989/deaths-related-to-differentiated-thyroid-cancer-a-rare-but-real-event
#9
Ana Kober N Leite, Beatriz G Cavalheiro, Marco Aurélio Kulcsar, Ana de Oliveira Hoff, Lenine G Brandão, Claudio Roberto Cernea, Leandro L Matos
Objective: The present study describes the clinical and tumor characteristics of patients that died from differentiated thyroid cancer and reports on the cause and circumstances of death in these cases. Subjects and methods: Retrospective analysis of all the differentiated thyroid cancer (DTC) related deaths at a single institution over a 5-year period, with a total of 33 patients. Results: Most of the patients were female (63.6%), with a mean age at diagnosis of 58...
May 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28699428/thyroid-stimulating-hormone-suppressive-therapy-for-low-risk-small-thyroid-cancer-a-propensity-score-matched-cohort-study
#10
Suyeon Park, Won Gu Kim, Minkyu Han, MinJi Jeon, Hyemi Kwon, Mijin Kim, Tae-Yon Sung, Tae Yong Kim, Won Bae Kim, Suck Joon Hong, YoungKee Shong
BACKGROUND: Thyroid-stimulating hormone (TSH) suppression has improved the clinical outcomes of patients with differentiated thyroid cancer (DTC). However, the efficacy of TSH suppressive therapy (TST) is unclear in patients with low-risk DTC. We aimed to evaluate the efficacy of TST and optimal TSH levels of patients with low-risk DTC. METHODS: The retrospective propensity-score matched cohort study included DTC patients (n = 446) who underwent lobectomy from 2002 to 2008 with or without TST (TST group and No-TST group)...
July 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28697325/direct-to-consumer-dna-testing-the-fallout-for-individuals-and-their-families-unexpectedly-learning-of-their-donor-conception-origins
#11
Marilyn Crawshaw
Increasing numbers of donor-conceived individuals (and/or parents) are seeking individuals genetically related through donor conception. One route is through 'direct-to-consumer' (DTC) DNA testing, prompting calls for fertility services to alert donors and prospective parents to the increasing unsustainability of anonymity and secrecy. The complexity of interpreting DNA results in this context has also been discussed, including their lack of absolute certainty, as has the need for professional and peer support...
July 11, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28696792/direct-to-consumer-genetic-testing-and-orphan-drug-development
#12
Matthew Mason, James Levenson, John Quillin
Since the introduction of the Orphan Drug Act (ODA) in 1983, orphan drug approvals in the United States have jumped from <100 per decade to over 200 per year. This growth is widely attributed to the financial incentives the ODA gives to companies that develop these medicines, and it is likely to continue for a unique reason: partnerships between pharmaceutical firms and direct-to-consumer (DTC) genetic testing companies. This emerging trend is the subject of this article, which begins by considering how rare-disease drugs are regulated and the rising interest in nonclinical genetic testing...
July 11, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28688696/prognostic-value-of-the-eighth-edition-ajcc-tnm-classification-for-differentiated-thyroid-carcinoma
#13
Tae Hyuk Kim, Young Nam Kim, Hye In Kim, So Young Park, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim, Young Lyun Oh, Soo Yeon Hahn, Jung Hee Shin, Kyunga Kim, Jong Gill Jeong, Sun Wook Kim, Jae Hoon Chung
BACKGROUND: The prognostic value of the proposed eighth edition of the American Joint Committee on Cancer (AJCC) tumor, node, and metastasis (TNM) classification is currently unclear. The aim of the study was to evaluate the prognostic value of the eighth edition of the AJCC TNM classification. METHODS: We retrospectively assessed 3176 patients with differentiated thyroid carcinoma (DTC) who underwent thyroidectomy at a tertiary Korean hospital from 1996 to 2005...
August 2017: Oral Oncology
https://www.readbyqxmd.com/read/28688088/early-stimulated-thyroglobulin-for-response-prediction-after-recombinant-human-thyrotropin-aided-radioiodine-therapy
#14
Hee Jeong Park, Jung-Joon Min, Hee-Seung Bom, Jahae Kim, Ho-Chun Song, Seong Young Kwon
OBJECTIVE: Measurement of recombinant human thyrotropin (rhTSH)-stimulated thyroglobulin (Tg) is generally recommended 72 h after the second rhTSH injection. However, due to the acute effect of I-131 on thyrocytes, Tg measured after radioiodine therapy (RIT) would not accurately reflect the thyroid tissue burden. We aimed to determine predictive values of serum Tg level measured just before rhTSH-aided RIT and to compare the results obtained just after RIT in patients with differentiated thyroid carcinoma (DTC)...
July 7, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28687563/axitinib-treatment-in-advanced-rai-resistant-differentiated-thyroid-cancer-dtc-and-refractory-medullary-thyroid-cancer-mtc
#15
Jaume Capdevila, Jose Manuel Trigo, Javier Aller, Jose Luis Manzano, Silvia Garcia-Adrian, Carles Zafon, Oscar Reig, Uriel Bohn, Teresa Ramon Y Cajal, Manuel Duran, Beatriz Gonzalez-Astorga, Ana Lopez-Alfonso, Javier Medina, Ignacio Porras, Juan Jose Reina, Nuria Palacios, Enrique Grande, Elena Cillan, Ignacio Matos, Juan Jose Grau
BACKGROUND: Axitinib, an antiangiogenic multikinase inhibitor (MKI) was evaluated in the compassionate-use-program in Spain (October 2012-November 2014). MATERIALS AND METHODS: 47 patients with advanced radioactive iodine-refractory differentiated thyroid cancer (DTC, n=34) or medullary thyroid cancer (MTC, n=13) with documented disease progression were treated with axitinib 5 mg bid. The primary efficacy endpoint was overall response rate (ORR) by RECIST v1.1. Progression-free survival (PFS) and adverse events (AEs) were secondary objectives...
July 7, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28685069/clinical-features-of-lenvatinib-treatment-in-elderly-patients-with-advanced-thyroid-cancer
#16
Koichi Suyama, Saori Fujiwara, Takashi Takeshita, Aiko Sueta, Touko Inao, Mutsuko Yamamoto-Ibusuki, Yutaka Yamamoto, Hirotaka Iwase
Until recently, there had not been an effective systemic chemotherapy for advanced differentiated thyroid carcinoma (DTC); lenvatinib, a multi-tyrosine kinase inhibitor, has been proven effective for DTC, but has also been revealed to have adverse side effects including hypertension, hand-foot syndrome (HFS) and diarrhea. There have been few clinical studies focused on the characteristics, safety concerns or precautions for lenvatinib treatment in elderly patients. The present study administered lenvatinib to 18 patients with DTC in Kumamoto University Hospital (Kumamoto, Japan), with 9 patients in both the younger group (<75 years old) and elderly group (≥75 years old)...
July 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28680291/patterns-of-failure-in-anaplastic-and-differentiated-thyroid-carcinoma-treated-with-intensity-modulated-radiotherapy
#17
H Vulpe, J Y Y Kwan, A McNiven, J D Brierley, R Tsang, B Chan, D P Goldstein, L W Le, A Hope, M Giuliani
BACKGROUND: The radiotherapy (rt) volumes in anaplastic (atc) and differentiated thyroid carcinoma (dtc) are controversial. METHODS: We retrospectively examined the patterns of failure after postoperative intensity-modulated rt for atc and dtc. Computed tomography images were rigidly registered with the original rt plans. Recurrences were considered in-field if more than 95% of the recurrence volume received 95% of the prescribed dose, out-of-field if less than 20% received 95% of the dose, and marginal otherwise...
June 2017: Current Oncology
https://www.readbyqxmd.com/read/28680197/association-between-volumetric-analysis-of-lung-metastases-on-f-18-fluoro-2-deoxy-d-glucose-positron-emission-tomography-computed-tomography-and-short-term-progression-after-i-131-therapy-for-differentiated-thyroid-carcinoma
#18
Yasuhiro Maruoka, Shingo Baba, Takuro Isoda, Yoshiyuki Kitamura, Koichiro Abe, Masayuki Sasaki, Hiroshi Honda
PURPOSE: Lung metastases (LMs) and their radioiodine uptake affect prognosis in patients with differentiated thyroid carcinoma (DTC). We herein investigate the value of metabolic tumor volume (MTV) in LMs on positron emission tomography/computed tomography (PET/CT) using 2-[F-18]-fluoro-2-deoxy-D-glucose (F-18 FDG PET/CT) in predicting short-term progression after initial I-131 therapy in DTC patients. MATERIALS AND METHODS: We retrospectively evaluated 111 DTC patients with LMs...
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28678595/the-unc-53-gene-negatively-regulates-rac-gtpases-to-inhibit-unc-5-activity-during-distal-tip-cell-migrations-in-c-elegans
#19
Amita Pandey, Vipul Yadav, Aditi Sharma, Jitendra P Khurana, Girdhar K Pandey
The unc-53/NAV2 gene encodes for an adaptor protein required for cell migrations along the anteroposterior (AP) axes of C. elegans. This study identifies unc-53 as a novel component of signaling pathways regulating distal tip cell (DTC) migrations along the AP and dorsoventral (DV) axes. unc-53 negatively regulates and functions downstream of ced-10/Rac pathway genes; ced-10/Rac and mig-2/RhoG, which are required for proper DTC migration. Moreover, unc-53 exhibits genetic interaction with abl-1 and unc-5, the two known negative regulators of ced-10/Rac signaling...
July 5, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28674152/human-arylamine-n-acetyltransferase-1-is-inhibited-by-the-dithiocarbamate-pesticide-thiram
#20
Ximing Xu, Cecile Mathieu, Jeremy Berthelet, Romain Duval, Linh Chi Bui, Florent Busi, Jean-Marie Dupret, Fernando Rodrigues-Lima
Thiram (tetramethylthiuram disulfide) is a representative dithiocarbamate (DTC) pesticide used in both the field and as a seed protectant. The widespread use of Thiram and other DTC pesticides has raised concerns for health as these compounds can exert neuropathic, endocrine disruptive and carcinogenic effects. These toxic effects are thought to rely, at least in part, on the reaction of Thiram (and certain of its metabolites) with cellular protein thiols with subsequent loss of protein function. So far, a limited number of molecular targets of Thiram have been reported including few enzymes such as dopamine β-hydroxylase, 11β-hydroxysteroid dehydrogenase and brain glycogen phosphorylase...
July 3, 2017: Molecular Pharmacology
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