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https://www.readbyqxmd.com/read/28734275/low-level-of-autophagy-related-gene-10-atg10-expression-in-the-6-hydroxydopamine-rat-model-of-parkinson-s-disease
#1
Marzieh Shams Nooraei, Ali Noori-Zadeh, Shahram Darabi, Farzad Rajaei, Zohreh Golmohammadi, Hojjat Allah Abbaszadeh
Background: Autophagy is a mechanism disassembling the damaged organelles from the cell. This study attempted to examine the expression of several autophagy-related genes in Parkinson’s disease (PD) rat model. Methods: The male Wistar rats were divided into three groups as control, sham, and lesion. In the latter group, the PD rat model was induced by the injection of 6-hydroxydopamine in the striatum.The behavioral test was conducted one (baseline) and four weeks after the surgery through apomorphine hydrochloride...
July 23, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28734274/genetic-analysis-of-iranian-patients-with-familial-hypercholesterolemia
#2
Mahdis Ekrami, Maryam Torabi, Soudeh Ghafouri-Fard, Javad Mowla, Bahram Mohammad Soltani, Feyzollah Hashemi-Gorji, Zahra Mohebbi, Mohammad Miryounesi
Background: Familial hypercholesterolemia (FH) is a frequent autosomal dominant disorder of lipoprotein metabolism. This disorder is generally caused by mutations in low-density lipoprotein receptor (LDLR), apolipoprotein B 100 (APOB), and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes. In the present study, we aimed at identifying the common LDLR and APOB gene mutations in an Iranian population. Methods: Eighty unrelated Iranian patients with FH entered the study, based on Simon Broome diagnostic criteria...
July 23, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28734269/crime-scene-reconstruction-sex-prediction-from-blood-stained-foot-sole-impressions
#3
Nabanita Basu, Samir Kumar Bandyopadhyay
It is often difficult to predict the sex of an individual based on bloody incomplete footprints. However, such prints/impressions are particularly common in a crime scene. Again variability in the texture, color of the target surface has an impact on the bloodstained impression formed. The study of bare foot, footprint, footwear (i.e. shoe, canvas etc.) within the legal context is referred to as forensic podiatry. Based on the fact that it is possible to predict the sex of an individual from footprint impressions, an automated model has been proposed in this paper for analyzing the sex of an individual from his/her broken/incomplete footprint impressions based on morphological features alone...
June 26, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28734268/dna-barcoding-allows-identification-of-european-fanniidae-diptera-of-forensic-interest
#4
Andrzej Grzywacz, Dominika Wyborska, Marcin Piwczyński
In forensic entomology practice, species identification is a prerequisite for any further analysis of collected material. Although morphology-based taxonomy may be hindered by a range of factors, these are not obstacles for a molecular identification approach, so-called DNA barcoding. The Fanniidae are a dipteran family that is attracted to and breeds in decomposing animal carrion and dead human bodies. However, morphological identification of fanniids, both at adult and immature stages, is considered to be difficult, particularly for non-experts...
June 29, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28734263/study-of-the-influencing-factors-of-the-blood-levels-of-toxic-elements-in-africans-from-16-countries
#5
Luis Alberto Henríquez-Hernández, Octavio P Luzardo, Luis D Boada, Cristina Carranza, José Luis Pérez Arellano, Ana González-Antuña, Maira Almeida-González, Carlos Barry-Rodríguez, Manuel Zumbado, María Camacho
Africa's economy is growing faster than any other continent and it has been estimated that the middle class in Africa now exceeds 350 million people. This has meant a parallel increase in the importation of consumer goods and in the implementation of communication and information technologies (ICT), but also in the generation of large quantities of e-waste. However, inadequate infrastructure development remains a major constraint to the continent's economic growth and these highly toxic residues are not always adequately managed...
July 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28734260/time-averaged-concentrations-are-effective-for-predicting-chronic-toxicity-of-varying-copper-pulse-exposures-for-two-freshwater-green-algae-species
#6
Brad M Angel, Stuart L Simpson, Ellissah Granger, Kathryn Goodwyn, Dianne F Jolley
Intermittent, fluctuating and pulsed contaminant discharges may result in organisms receiving highly variable contaminant exposures. This study investigated the effects of dissolved copper pulse concentration and exposure duration on the toxicity to two freshwater green algae species. The effects of single copper pulses of between 1 and 48 h duration and continuous exposures (72 h) on growth rate inhibition of Pseudokirchneriella subcapitata and Chlorella sp. were compared on a time-averaged concentration (TAC) basis...
July 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28734258/mechanical-properties-and-biocompatibility-of-porous-titanium-scaffolds-for-bone-tissue-engineering
#7
Yunhui Chen, Jessica Ellen Frith, Ali Dehghan-Manshadi, Hooyar Attar, Damon Kent, Nicolas Dominique Mathieu Soro, Michael J Bermingham, Matthew S Dargusch
Synthetic scaffolds are a highly promising new approach to replace both autografts and allografts to repair and remodel damaged bone tissue. Biocompatible porous titanium scaffold was manufactured through a powder metallurgy approach. Magnesium powder was used as space holder material which was compacted with titanium powder and removed during sintering. Evaluation of the porosity and mechanical properties showed a high level of compatibility with human cortical bone. Interconnectivity between pores is higher than 95% for porosity as low as 30%...
July 13, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28734253/polybrominated-diphenyl-ether-flame-retardant-concentrations-in-faeces-from-young-children-in-queensland-australia-and-associations-with-environmental-and-behavioural-factors
#8
Karin English, Yiqin Chen, Leisa-Maree Toms, Paul Jagals, Robert S Ware, Jochen F Mueller, Peter D Sly
The aim of our study was to investigate children's exposure to the flame retardants polybrominated diphenyl ethers (PBDEs) by analysing faecal content, a non-invasive matrix, as well as responses to an exposure-assessment questionnaire. A convenience sample of 61 parents with children (aged >3 months to <2 years) completed an online pre-tested questionnaire and provided faecal samples for analysis by high resolution gas chromatography/mass spectrometry. BDE-209 was the dominant congener in faecal samples adjusted to 8...
July 19, 2017: Environmental Research
https://www.readbyqxmd.com/read/28734252/river-sequesters-atmospheric-carbon-and-limits-the-co2-degassing-in-karst-area-southwest-china
#9
Tao Zhang, Jianhong Li, Junbing Pu, Jonathan B Martin, Mitra B Khadka, Feihong Wu, Li Li, Feng Jiang, Siyu Huang, Daoxian Yuan
CO2 fluxes across water-air interfaces of river systems play important roles in regulating the regional and global carbon cycle. However, great uncertainty remains as to the contribution of these inland water bodies to the global carbon budget. Part of the uncertainty stems from limited understanding of the CO2 fluxes at diurnal and seasonal frequencies caused by aquatic metabolism. Here, we measured surface water characteristics (temperature, pH, and DO, DIC, Ca(2+) concentrations) and CO2 fluxes across the air-water interface at two transects of Guijiang River, southwest China to assess the seasonal and diurnal dynamics of fluvial carbon cycling and its potential role in regional and global carbon budgets...
July 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28734251/climatic-controls-of-ecohydrological-responses-in-the-highlands-of-northern-ethiopia
#10
Samuale Tesfaye, Emiru Birhane, Toon Leijnse, S E A T M van der Zee
Climate variability and recurrent droughts have a strong negative impact on agricultural production and hydrology in the highlands northern Ethiopia. Since the 1980s, numerous mitigation and land rehabilitation measures have been implemented by local and national authorities to reduce these impacts, are often poorly effective. As underlying reason may be that controlling relationships between climate and ecohydrology at medium-sized catchments (10-10,000km(2)) of semi-arid highlands are not well known. We investigated trends and relationships in precipitation, temperature, streamflow, and net primary productivity (NPP)...
July 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28734250/assessment-of-direct-exposure-and-leaching-risk-from-pahs-in-roadway-and-stormwater-system-residuals
#11
Edmund Azah, Hwidong Kim, Timothy Townsend
Wastes generated from municipal cleaning activities such as street sweeping, ditch cleaning, stormwater pond maintenance, and catch basin sediment removal require appropriate management. Beneficial use of these types of waste is a good alternative to landfilling; however, there are genuine concerns about possible soil and groundwater contamination by pollutants such as polycyclic aromatic hydrocarbons (PAHs). This study assessed the potential risks associated with beneficial use of roadway and stormwater system residuals collected from 14 cities across the state of Florida, USA...
July 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28734249/nitrogen-losses-and-greenhouse-gas-emissions-under-different-n-and-water-management-in-a-subtropical-double-season-rice-cropping-system
#12
Kaiming Liang, Xuhua Zhong, Nongrong Huang, Rubenito M Lampayan, Yanzhuo Liu, Junfeng Pan, Bilin Peng, Xiangyu Hu, Youqiang Fu
Nitrogen non-point pollution and greenhouse gas (GHG) emission are major challenges in rice production. This study examined options for both economic and environmental sustainability through optimizing water and N management. Field experiments were conducted to examine the crop yields, N use efficiency (NUE), greenhouse gas emissions, N losses under different N and water management. There were four treatments: zero N input with farmer's water management (N0), farmer's N and water management (FP), optimized N management with farmer's water management (OPTN) and optimized N management with alternate wetting and drying irrigation (OPTN+AWD)...
July 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28734247/seasonal-variation-in-water-uptake-patterns-of-three-plant-species-based-on-stable-isotopes-in-the-semi-arid-loess-plateau
#13
Jian Wang, Bojie Fu, Nan Lu, Li Zhang
Water is a limiting factor and significant driving force for ecosystem processes in arid and semi-arid areas. Knowledge of plant water uptake pattern is indispensable for understanding soil-plant interactions and species coexistence. The 'Grain for Green' project that started in 1999 in the Loess Plateau of China has led to large scale vegetation change. However, little is known about the water uptake patterns of the main plant species that inhabit in this region. In this study, the seasonal variations in water uptake patterns of three representative plant species, Stipa bungeana, Artemisia gmelinii and Vitex negundo, that are widely distributed in the semi-arid area of the Loess Plateau, were identified by using dual stable isotopes of δ(2)H and δ(18)O in plant and soil water coupled with a Bayesian mixing model MixSIAR...
July 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28734246/topological-pattern-for-the-search-of-new-active-drugs-against-methicillin-resistant-staphylococcus-aureus
#14
Jose I Bueso-Bordils, Maria T Perez-Gracia, Beatriz Suay-Garcia, Maria J Duart, Rafael V Martin Algarra, Luis Lahuerta Zamora, Gerardo M Anton-Fos, Pedro A Aleman Lopez
Molecular topology was used to develop a mathematical model capable of classifying compounds according to antimicrobial activity against methicillin resistant Staphylococcus aureus (MRSA). Topological indices were used as structural descriptors and their relation to antimicrobial activity was determined by using linear discriminant analysis. This topological model establishes new structure activity relationships which show that the presence of cyclopropyl, chlorine and ramification pairs at a distance of two bonds favor this activity, while the presence of tertiary amines decreases it...
July 8, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28734245/azaphenothiazines-promising-phenothiazine-derivatives-an-insight-into-nomenclature-synthesis-structure-elucidation-and-biological-properties
#15
REVIEW
Krystian Pluta, Małgorzata Jeleń, Beata Morak-Młodawska, Michał Zimecki, Jolanta Artym, Maja Kocięba, Ewa Zaczyńska
For the last two decades, classical phenothiazines have attracted attention of researchers, as the hitherto investigations have revealed many significant biological activities within this class of compounds, other than originally discovered neuroleptic ones. Important, new pharmaceutical results on phenothiazines, as 10-substituted dibenzothiazines, were recently highlighted in several reviews. Azaphenothiazines are structurally modified phenothiazines by substitution of one or both benzene rings in the phenothiazine ring system with the azine rings, such as: pyridine, pyridazine, pyrimidine, pyrazine, 1,2,4-triazine, quinoline, quinoxaline, benzoxazine and benzothiazine...
July 8, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28734241/entrapment-perceived-burdensomeness-and-thwarted-belongingness-as-predictors-of-suicide-ideation
#16
Thomas Forkmann, Tobias Teismann
The Integrated Motivational-Volitional (IMV) Model of suicide posits that perceived burdensomeness and thwarted belongingness moderate the association between perceptions of entrapment and suicide ideation. However, the proposed moderation is yet to be tested. Possible moderator effects were investigated in an online sample (N = 480; 74% female; Mage = 28.5, SDage = 11.1). Entrapment and perceived burdensomeness predicted suicide ideation. However, neither perceived burdensomeness nor thwarted belongingness moderated the association between entrapment and suicide ideation...
July 16, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28734240/decreased-levels-of-serum-fibroblast-growth-factor-2-in-children-with-autism-spectrum-disorder
#17
Erman Esnafoglu, Sema Nur Ayyıldız
The neurodevelopment and functioning of the central nervous system, and especially the cerebral cortex, have basic importance to understand neuropsychiatric disorders like autism. Fibroblast growth factor-2 (FGF-2) plays a very important role in the development and functioning of the cortex. FGF-2 is related to developmental processes in the central nervous system such as neurogenesis, migration, differentiation and survival. This study researched the serum FGF-2 levels in children with autism spectrum disorder (ASD)...
July 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28734239/stigma-resistance-and-its-association-with-internalised-stigma-and-psychosocial-outcomes-among-psychiatric-outpatients
#18
Ying Wen Lau, Louisa Picco, Shirlene Pang, Anitha Jeyagurunathan, Pratika Satghare, Siow Ann Chong, Mythily Subramaniam
Studies have suggested that stigma resistance plays an important role in the recovery from mental illness. However, there has been limited research in Asian countries that has examined the benefits of stigma resistance among the mentally ill in Asian populations. Hence, this study aimed to assess the prevalence of stigma resistance and establish the socio-demographic correlates of stigma resistance, as well as its association with internalised stigma and psychosocial outcomes among a multi-ethnic population of 280 outpatients with obsessive compulsive disorder (OCD), schizophrenia, depressive disorders and anxiety disorders in Singapore...
July 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28734235/characterization-of-cognitive-performance-and-evaluation-of-quality-of-life-among-patients-with-htlv-1
#19
Liliana Raulino Goncalves, Leopoldo Nelson Fernandes Barbosa, Paula Machado Ribeiro Magalhaes, Pedro Augusto Sampaio Rocha-Filho
OBJECTIVE: To characterize cognitive alterations among patients with HTLV-1, ascertain what is associated with these alterations and evaluate these patients' quality of life. PATIENTS AND METHODS: This was a cross-sectional study. Patients infected by HTLV-1 who were seen at the Oswaldo Cruz University Hospital from March 2014 to June 2015 were included in the study. A semi-structured questionnaire and the Mini-Mental State Examination, Color Trails Test, Wechsler Adult Intelligence Scale (WAIS-III), Hospital Anxiety and Depression Scale and Medical Outcomes Study 36-Item Short-Form Health Survey (SF36) were used...
July 12, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28734228/effect-of-education-on-ability-of-ai-professionals-and-herd-owner-inseminators-to-detect-cows-not-in-oestrus-and-its-relation-with-progesterone-concentration-on-day-of-re-insemination
#20
K Vartia, J Taponen, J Heikkinen, H Lindeberg
The effect of training background of persons performing artificial insemination (AI) (herd-owner inseminators (OWNER), AI technicians (AI-T), and fertility consultants (FC)) on pregnancy rate and their ability to detect cows not in oestrus were studied. A total of 1584 re-AI occasions on 754 dairy farms were included. Milk samples for progesterone (P4) analysis in all cases were collected, as were data on the herd, previous breeding attempts, oestrous signs, uterine tone, slipperiness of cervix, and co-operation of the cow...
July 13, 2017: Theriogenology
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