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https://www.readbyqxmd.com/read/27933750/comparing-glucose-and-hemoglobin-a1c-diagnostic-tests-among-a-high-metabolic-risk-hispanic-population
#1
Mónica A Vega-Vázquez, Margarita Ramirez-Vick, Francisco J Muñoz-Torres, Loida A González-Rodríguez, Kaumudi Joshipura
AIMS: Compare HbA1c diagnostic tests for pre-diabetes and diabetes with plasma glucose criteria (PGC), and compare the metabolic profiles of people classified by HbA1c versus by glucose levels. METHODS: Participants were recruited for the San Juan Overweight Adults Longitudinal Study (SOALS). Were primarily Hispanic (98%), without previously diagnosed diabetes, and aged 40-65 years. Participants classified as normal glycemic, pre-diabetes or diabetes based on baseline HbA1c and PGC, were compared with respect to baseline cardiometabolic factors...
December 9, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27933749/black-magic-in-gray-titania-noble-metal-free-photocatalytic-h2-evolution-from-hydrogenated-anatase
#2
Ning Liu, Xuemei Zhou, Nhat Truong Nguyen, Kristina Peters, Florian Zoller, Imgon Hwang, Christopher Schneider, Matthias E Miehlich, Detlef Freitag, Karsten Meyer, Dina Fattakhova-Rohlfing, Patrik Schmuki
'Black' TiO2 -in the widest sense, TiO2 reduced by various treatments-has attracted tremendous scientific interest in recent years because of some outstanding properties; most remarkably in photocatalysis. While the material effects visible light absorption (the blacker, the better), black titania produced by high pressure hydrogenation was recently reported to show another highly interesting feature; noble-metal-free photocatalytic H2 generation. In a systematic investigation of high-temperature hydrogen treatments of anatase nanoparticles, TEM, XRD, EPR, XPS, and photoelectrochemistry are used to characterize different degrees of surface hydrogenation, surface termination, electrical conductivity, and structural defects in the differently treated materials...
December 9, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27933748/exploring-glucocorticoid-receptor-agonists-mechanism-of-action-through-mass-cytometry-and-radial-visualizations
#3
Yann Abraham, Bertran Gerrits, Marie-Gabrielle Ludwig, Michael Rebhan, Caroline Gubser Keller
Recent advances in combining flow cytometry and mass spectrometry have led to the development of mass cytometry, allowing for the interrogation of complex cell populations on an unprecedented scale. The volumes and high dimensionality of mass cytometry data pose significant challenges in terms of analysis and visualization. We implement a method called Radviz (1-3), where multidimensional single cell data can be visualized as a projection that maintains the original dimensions and data complexity whilst facilitating analysis and visualization...
December 9, 2016: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/27933740/fine-needle-aspiration-in-the-diagnosis-and-classification-of-hepatoblastoma-analysis-of-21-new-cases
#4
Tatjana Vlajnic, Hervé J Brisse, Isabelle Aerts, Paul Fréneaux, Cécile Cellier, Monique Fabre, Jerzy Klijanienko
BACKGROUND: Diagnosis of hepatoblastoma (HBL) is based on characteristic clinical and radiological presentation, young age and marked elevation of serum α-fetoprotein (aFP). Fine needle aspiration (FNA) technique is successfully used in the diagnosis of hepatoblastoma. To evaluate the value of FNA in the diagnosis and subtyping of HBL, we report our experience correlated to histological sections (core needle biopsy, CNB). METHODS: From 1991 to 2015, 21 cases from 20 patients were cytologically diagnosed as HBL...
December 9, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27933738/exploratory-analysis-of-textual-data-from-the-mother-and-child-handbook-using-a-text-mining-method-ii-monthly-changes-in-the-words-recorded-by-mothers
#5
Miki Tagawa, Yoshio Matsuda, Tomoko Manaka, Makiko Kobayashi, Michitaka Ohwada, Shigeki Matsubara
AIM: The aim of the study was to examine the possibility of converting subjective textual data written in the free column space of the Mother and Child Handbook (MCH) into objective information using text mining and to compare any monthly changes in the words written by the mothers. METHODS: Pregnant women without complications (n = 60) were divided into two groups according to State-Trait Anxiety Inventory grade: low trait anxiety (group I, n = 39) and high trait anxiety (group II, n = 21)...
December 9, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27933737/testing-the-influence-of-surfactant-based-wound-dressings-on-proteinase-activity
#6
Sunyoung Jeong, Gregory S Schultz, Daniel J Gibson
Proteinases are enzymes that can digest other proteins. In chronic wounds, a sub-class of these enzymes with the ability to degrade the extracellular matrix (matrix metalloproteinases, MMPs) have been found to both inhibit healing and to be able to aid in enzymatically debriding a wound. Enzymatic debridement using the enzymes present in a wound is generally called autolytic debridement. Clinicians seeking to employ autolytic debridement typically use occlusive materials such as medical honey, alginate dressings and other occlusive dressings...
December 8, 2016: International Wound Journal
https://www.readbyqxmd.com/read/27933734/improved-quality-of-life-in-asthma-patients-under-long-term-therapy-assessed-by-ahq-japan
#7
Yuji Tohda, Takashi Iwanaga, Hiroyuki Sano, Hiroaki Kume, Kazuto Hirata, Noriyuki Ohkura, Isao Tachibana, Yoshihiro Nishimura, Hisako Matsumoto, Yoshiaki Minakata, Masanori Yoshikawa, Masaki Fujimura
BACKGROUND AND OBJECTIVES: Assessment of the effects of long-term management on patient quality of life (QOL) would be extremely useful for determining asthma treatment strategies. However, no studies have evaluated QOL over an extended period of time. This study evaluated the changes in QOL, drug management and disease severity in the same asthma patients at an interval of approximately 9 years. METHODS: We re-surveyed asthma patients enrolled in a survey conducted in 2004 to evaluate the effects of approximately a decade of treatment on disease severity and QOL assessed by the Japanese Asthma Health Questionnaire (AHQ-JAPAN)...
December 9, 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27933732/hypothesis-driven-physical-examination-curriculum
#8
Sharon Allen, Andrew Olson, Jeremiah Menk, James Nixon
BACKGROUND: Medical students traditionally learn physical examination skills as a rote list of manoeuvres. Alternatives like hypothesis-driven physical examination (HDPE) may promote students' understanding of the contribution of physical examination to diagnostic reasoning. We sought to determine whether first-year medical students can effectively learn to perform a physical examination using an HDPE approach, and then tailor the examination to specific clinical scenarios. Medical students traditionally learn physical examination skills as a rote list of manoeuvres CONTEXT: First-year medical students at the University of Minnesota were taught both traditional and HDPE approaches during a required 17-week clinical skills course in their first semester...
December 9, 2016: Clinical Teacher
https://www.readbyqxmd.com/read/27933731/independent-risk-factors-for-the-development-of-skin-erosion-due-to-incontinence-incontinence-associated-dermatitis-category-2-in-nursing-home-residents-results-from-a-multivariate-binary-regression-analysis
#9
Nele Van Damme, Karen Van den Bussche, Dorien De Meyer, Ann Van Hecke, Sofie Verhaeghe, Dimitri Beeckman
The aim of this study was to identify characteristics independently associated with a higher risk of developing skin damage because of incontinence [incontinence-associated dermatitis (IAD) category 2] in nursing home residents. As part of a larger randomised controlled trial, IAD incidence was monitored for 1 month in a sample of 381 incontinent residents using a validated IAD Severity Categorisation Tool. Data on demographical, physical, functional and psychological characteristics were collected. The overall IAD incidence (category 1-2) was 30·0%, and 6% of the participants developed skin damage (IAD category 2)...
December 9, 2016: International Wound Journal
https://www.readbyqxmd.com/read/27933725/cellular-engineering-for-therapeutic-protein-production-product-quality-host-modification-and-process-improvement
#10
REVIEW
Evan Wells, Anne Skaja Robinson
Recombinant proteins offer many therapeutic advantages unavailable in traditional small molecule drugs, but the need for cellular versus chemical synthesis complicates production. Avenues for producing therapeutic biologics are continuously expanding, and developments in biochemistry, cell biology, and bioengineering fuel new discoveries that promise safer, more efficient, and cheaper drugs for consumers. Numerous approaches to express recombinant proteins exist, but Escherichia coli, Saccharomyces cerevisiae, and mammalian systems (e...
December 9, 2016: Biotechnology Journal
https://www.readbyqxmd.com/read/27933724/comparative-analysis-reveals-amino-acids-critical-for-anticancer-activity-of-peptide-cigb-552
#11
Soledad Astrada, Yolanda Gomez, Exequiel Barrera, Gonzalo Obal, Otto Pritsch, Sergio Pantano, Maribel G Vallespí, Mariela Bollati-Fogolín
Because of resistance development by cancer cells against current anticancer drugs, there is a considerable interest in developing novel antitumor agents. We have previously demonstrated that CIGB-552, a novel cell-penetrating synthetic peptide, was effective in reducing tumor size and increasing lifespan in tumor-bearing mice. Studies of protein-peptide interactions have shown that COMMD1 protein is a major mediator of CIGB-552 antitumor activity. Furthermore, a typical serine-protease degradation pattern for CIGB-552 in BALB/c mice serum was identified, yielding peptides which differ from CIGB-552 in size and physical properties...
November 2016: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/27933723/comfa-topomer-comfa-and-hqsar-studies-on-a-series-of-novel-hiv-1-protease-inhibitors
#12
Afsane Heidari, Mohammad H Fatemi
Comparative molecular field analysis (CoMFA), topomer CoMFA and hologram QSAR (HQSAR) as three efficient methods of QSAR have been performed on 40 newly synthesized inhibitors against HIV-1 protease. Molecular alignment was done by aid of crystallographic structure of template inhibitor (indirectly alignment) and also by the molecular mechanic (MM) minimized structure. Both alignment methods produced satisfactory statistics for training set, but indirectly alignment had more predictive power. Generated counter maps, especially by topomer CoMFA, give comprehensive information about structural features affecting the inhibitory activities of studied chemicals...
December 9, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27933720/autogenous-bone-grafting-for-treatment-of-osseous-defect-after-impacted-mandibular-third-molar-extraction-a-randomized-controlled-trial
#13
Jing Ge, Chi Yang, Jiawei Zheng, Yingkai Hu
BACKGROUND: Extraction of impacted mandibular third molar (M3) has been cited as causing osseous defect at the distal aspect of the adjacent second molar (M2). PURPOSE: This randomized controlled trial was aimed to evaluate the effect of autogenous bone grafting in situ for regeneration of periodontal osseous defect distal to the M2 compared with non-grafting after impacted M3 removal. MATERIALS AND METHODS: A total of 60 sites in 51 adult patients were enrolled and randomly assigned to the control group or the test group...
December 8, 2016: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/27933719/depth-profiling-cross-linked-poly-methyl-methacrylate-films-a-tof-sims-approach
#14
Soheila Naderi-Gohar, Kevin M H Huang, Yiliang Wu, Woon Ming Lau, Heng-Yong Nie
RATIONALE: In order to determine the degree of cross-linking on the surface and its variations in a nanometer-scale depth of organic materials, we developed an approach based on time-of-flight secondary ion mass spectrometry (TOF-SIMS), which provides rich chemical information in the form of fragment ions. TOF-SIMS is extremely surface sensitive and capable of depth profiling with the use of a sputter ion beam to remove controllable amounts of substance. METHODS: Poly(methyl methacrylate) (PMMA) films spin-coated on a Si substrate were cross-linked using a recently developed, surface sensitive, hyperthermal hydrogen projectile bombardment technique...
December 9, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/27933718/constipation-in-older-people-a-consensus-statement
#15
Anton Emmanuel, Francesco Mattace-Raso, Maria Cristina Neri, Karl-Uwe Petersen, Enrique Rey, June Rogers
BACKGROUND AND AIMS: Chronic constipation is a serious medical condition that affects 30%-40% of people over 60 years old. Although not normally life threatening, constipation reduces quality of life by the same extent as diabetes and osteoarthritis. There are currently no Europe-wide guidelines for treating constipation in older people, although there is some country-level guidance for the general population. We have evaluated the existing guidance and best clinical practice to improve the care of older people with constipation...
December 9, 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27933717/mass-cytometry-analytical-approaches-reveal-cytokine-induced-changes-in-natural-killer-cells
#16
Elena Vendrame, Julia Fukuyama, Dara M Strauss-Albee, Susan Holmes, Catherine A Blish
BACKGROUND: Natural killer (NK) cells have antiviral and antitumor activity that could be harnessed for the treatment of infections and malignancies. To maintain cell viability and enhance antiviral and antitumor effects, NK cells are frequently treated with cytokines. Here we performed an extensive assessment of the effects of cytokines on the phenotype and function of human NK cells. METHODS: We used cytometry by time-of-flight (CyTOF) to evaluate NK cell repertoire changes after stimulation with interleukin (IL)-2, IL-15 or a combination of IL- 12/IL-15/IL-18...
December 9, 2016: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/27933714/development-of-chemical-tools-to-monitor-and-control-isoaspartyl-peptide-methyltransferase-activity
#17
Yusuke Kimura, Toru Komatsu, Kouichi Yanagi, Kenjiro Hanaoka, Tasuku Ueno, Takuya Terai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Yasuteru Urano
We have established a coupled assay system targeting protein l-isoaspartyl methyltransferase (PIMT), a key enzyme in the metabolism of isoaspartyl peptides and proteins. The system utilizes a fluorogenic peptide probe containing an isoaspartyl residue at the P1' position of the caspase-3 recognition sequence. Following PIMT-catalyzed methyl transfer reaction, the methylated probe is specifically cleaved by caspase-3 to give fluorescence activation. High-throughput screening of our chemical library with this assay system identified PIMT inhibitors that may be useful as leads in the design of chemical probes for controlling PIMT activity...
December 9, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27933712/the-importance-of-mrna-structure-in-determining-the-pathogenicity-of-synonymous-and-non-synonymous-mutations-in-haemophilia
#18
N Hamasaki-Katagiri, B C Lin, J Simon, R C Hunt, T Schiller, E Russek-Cohen, A A Komar, H Bar, C Kimchi-Sarfaty
INTRODUCTION: Mutational analysis is commonly used to support the diagnosis and management of haemophilia. This has allowed for the generation of large mutation databases which provide unparalleled insight into genotype-phenotype relationships. Haemophilia is associated with inversions, deletions, insertions, nonsense and missense mutations. Both synonymous and non-synonymous mutations influence the base pairing of messenger RNA (mRNA), which can alter mRNA structure, cellular half-life and ribosome processivity/elongation...
December 9, 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27933702/multiparameter-particle-display-mppd-a-quantitative-screening-method-for-the-discovery-of-highly-specific-aptamers
#19
Jinpeng Wang, Jingwen Yu, Qin Yang, John McDermott, Alexander Scott, Matthew Vukovich, Remy Lagrois, Qiang Gong, William Greenleaf, Michael Eisenstein, B Scott Ferguson, H Tom Soh
Aptamers are a promising class of affinity reagents because they are chemically synthesized, thus making them highly reproducible and distributable as sequence information rather than a physical entity. Although many high-quality aptamers have been previously reported, it is difficult to routinely generate aptamers that possess both high affinity and specificity. One of the reasons is that conventional aptamer selection can only be performed either for affinity (positive selection) or for specificity (negative selection), but not both simultaneously...
December 9, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27933696/commentary-on-blue-blocking-glasses-as-additive-treatment-for-mania-a-randomized-placebo-controlled-trial
#20
Amílcar Silva-Dos-Santos
No abstract text is available yet for this article.
December 9, 2016: Bipolar Disorders
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