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https://www.readbyqxmd.com/read/29166332/testicular-estrogen-secreting-leydig-cell-tumor-in-18f-fdg-pet-ct-an-incidental-detection-in-a-patient-treated-by-chemotherapy-for-hodgkin-lymphoma
#1
Axel Van Der Gucht, Zaher Maged, Rodolfo Burruni, Jean-Luc Barras, Niklaus Schaefer
We present images of a 50-year-old man who referred for treatment of a classic Hodgkin lymphoma. While F-FDG PET/CT demonstrated a complete metabolic remission after chemotherapy, an increased F-FDG uptake of a right testicular lesion in F-FDG PET/CT and an unexplained bilateral gynecomastia were observed. A benign Leydig cell tumor was histopathologically proved after a right radical orchiectomy. The serum estradiol level was abnormally elevated reflecting the estrogen-secreting profile. This report highlights that a focal F-FDG uptake in the testicular region with unexplained gynecomastia should suggest the diagnosis of an estrogen-secreting Leydig cell tumor on F-FDG PET/CT...
November 22, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29165691/estradiol-protects-proopiomelanocortin-neurons-against-insulin-resistance
#2
Jian Qiu, Martha A Bosch, Cecilia Meza, Uyen-Vy Navarro, Casey C Nestor, Edward J Wagner, Oline K Rønnekleiv, Martin J Kelly
Insulin resistance is at the core of the metabolic syndrome, and men exhibit a higher incidence of metabolic syndrome than women in early adult life, but this sex advantage diminishes sharply when women reach the postmenopausal state. Since 17β-estradiol (E2) augments the excitability of the anorexigenic POMC neurons, we investigated the neuroprotective effects of E2 against insulin resistance in POMC neurons from diet-induced obese (DIO) female and male mice. The efficacy of insulin to activate canonical transient receptor potential 5 (TRPC5) channels and depolarize POMC neurons was significantly reduced in DIO male but not in DIO female mice...
November 20, 2017: Endocrinology
https://www.readbyqxmd.com/read/29165663/oral-contraceptives-and-cigarette-smoking-a-review-of-the-literature-and-future-directions
#3
Alicia M Allen, Andrea H Weinberger, Reagan R Wetherill, Carol L Howe, Sherry A McKee
Introduction: Evidence continues to mount indicating that endogenous sex hormones (e.g., progesterone and estradiol) play a significant role in smoking-related outcomes. Although approximately 1 out of 4 premenopausal smokers use oral contraceptives (OCs), which significantly alter progesterone and estradiol levels, relatively little is known about how OCs may influence smoking-related outcomes. Thus, the goal of this review paper is to describe the state of the literature and offer recommendations for future directions...
November 18, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29165635/breast-development-in-transwomen-after-one-year-of-cross-sex-hormone-therapy-results-of-a-prospective-multicenter-study
#4
Christel Josefa Maria de Blok, Maartje Klaver, Chantal Maria Wiepjes, Nienke Marije Nota, Annemieke Corine Heijboer, Alessandra Daphne Fisher, Thomas Schreiner, Guy T'Sjoen, Martin den Heijer
Context: Breast development is a key feature of feminization and therefore important to transwomen (male-to-female transgender persons). However, it is not exactly known when breast development starts after initiating cross-sex hormone therapy (CHT) and how much growth may be expected of CHT alone. Objective: To investigate breast development in centimeters and bra cup-sizes in transwomen during their first year of CHT, and whether clinical or laboratory parameters predict the breast development...
November 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29165623/effects-of-pharmacologic-and-nonpharmacologic-interventions-on-insomnia-symptoms-and-subjective-sleep-quality-in-women-with-hot-flashes-a-pooled-analysis-of-individual-participant-data-from-4-msflash-trials
#5
Katherine A Guthrie, Joseph C Larson, Kristine E Ensrud, Garnet L Anderson, Janet S Carpenter, Ellen W Freeman, Hadine Joffe, Andrea Z LaCroix, JoAnn E Manson, Charles M Morin, Katherine M Newton, Julie Otte, Susan D Reed, Susan M McCurry
Study Objectives: The Menopause Strategies: Finding Lasting Answers for Symptoms and Health network conducted three randomized clinical trials (RCT) testing six interventions treating vasomotor symptoms (VMS), and also collected self-reported sleep outcomes. A fourth RCT assessed an intervention for insomnia symptoms among women with VMS. We describe these seven interventions' effects relative to control in women with comparably severe insomnia symptoms and VMS. Methods: We analyzed pooled individual-level data from 546 peri- and postmenopausal women with Insomnia Severity Index (ISI) >12, and ≥14 bothersome VMS/week across the four RCTs...
November 20, 2017: Sleep
https://www.readbyqxmd.com/read/29165555/prenatal-exposure-to-di-2-ethylhexyl-phthalate-dehp-disrupts-ovarian-function-in-a-transgenerational-manner-in-female-mice
#6
Saniya Rattan, Emily Brehm, Liying Gao, Sarah Niermann, Jodi A Flaws
Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer found in polyvinyl chloride products such as vinyl flooring, plastic food containers, medical devices, and children's toys. DEHP is a ubiquitous environmental contaminant and is a known endocrine disrupting chemical. Little is known about the effects of prenatal DEHP exposure on the ovary and whether effects occur in subsequent generations. Thus, we tested the hypothesis that prenatal exposure to DEHP disrupts ovarian functions in the F1, F2, and F3 generations of female mice...
November 20, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29164590/the-effect-of-abdominal-obesity-in-patients-with-polycystic-ovary-syndrome-on-metabolic-parameters
#7
G Franik, A Bizoń, S Włoch, D Pluta, Ł Blukacz, H Milnerowicz, P Madej
OBJECTIVE: Polycystic ovarian syndrome and obesity contribute to the metabolic complications for women of reproductive age. The aim of present study was to analyze the effect of abdominal obesity expressed using waist/hip ratio (WHR) in patients with polycystic ovary syndrome on metabolic parameters. PATIENTS AND METHODS: The study included 659 women with PCOS with WHR <0.8 and ≥0.8 aged between 17 and 44 years. Patients were tested for follicular stimulating hormone, luteinizing hormone, 17-beta-estradiol, dehydroepiandrosterone sulfate, androstenedione, sex hormone binding globulin, and total lipid profile during the follicular phase (within 3 and 5 days of their menstrual cycle)...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164510/4-year-changes-in-sex-hormones-sexual-functioning-and-psychosocial-status-in-women-who-underwent-bariatric-surgery
#8
David B Sarwer, Thomas A Wadden, Jacqueline C Spitzer, James E Mitchell, Kathy Lancaster, Anita Courcoulas, William Gourash, Raymond C Rosen, Nicholas J Christian
BACKGROUND: Initial weight loss after bariatric surgery has been associated with improvements in reproductive hormones and sexual functioning in women. Few studies have investigated the durability of these changes. OBJECTIVES: The objective of this paper is to investigate changes in sex hormones, sexual functioning, and relevant psychosocial constructs over 4 years in women who underwent bariatric surgery. SETTING: The setting is a prospective cohort of 106 women from the Longitudinal Assessment of Bariatric Surgery consortium...
November 21, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29164377/systemic-and-local-effects-of-vaginal-dehydroepiandrosterone-dhea-ncctg-n10c1-alliance
#9
Debra L Barton, Lynne T Shuster, Travis Dockter, Pamela J Atherton, Jacqueline Thielen, Stephen N Birrell, Richa Sood, Patricia Griffin, Shelby A Terstriep, Bassam Mattar, Jacqueline M Lafky, Charles L Loprinzi
BACKGROUND: Dehydroepiandrosterone (DHEA) is helpful for treating vaginal symptoms. This secondary analysis evaluated the impact of vaginal DHEA on hormone concentrations, bone turnover, and vaginal cytology in women with a cancer history. METHODS: Postmenopausal women, diagnosed with breast or gynecologic cancer, were eligible if they reported at least moderate vaginal symptoms. Participants could be on tamoxifen or aromatase inhibitors (AIs). Women were randomized to 3...
November 21, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29164263/plasma-leptin-and-premenstrual-syndrome-a-review
#10
Zaira Fernanda Martinho Nicolau, Andréia Gomes Bezerra, Daniel Ninello Polesel, Monica Levy Andersen, Sergio Tufik, Helena Hachul
Importance: Premenstrual syndrome (PMS) is characterized by physical and psychological symptoms in the luteal phase. Leptin can influence PMS as it acts on the hypothalamic-pituitary-gonadal axis. Objective: The aim of this study was to evaluate data in the literature about the profile of plasma leptin in women with PMS. Evidence Acquisition: We performed a search of databases using both descriptors. Three studies were identified. They included 181 participants...
November 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/29163355/regulation-of-gonadotropin-releasing-hormone-1-5-signaling-genes-by-estradiol-is-age-dependent
#11
Bradly M Bauman, Weiling Yin, Andrea C Gore, T John Wu
Gonadotropin-releasing hormone (GnRH) is a key regulatory molecule of the hypothalamus-pituitary (PIT)-gonadal (HPG) axis that ultimately leads to the downstream release of estradiol (E2) and progesterone (P). These gonadal steroids feed back to the hypothalamus and PIT to regulate reproductive function and behavior. While GnRH is thought to be the master regulator of reproduction, its metabolic product GnRH-(1-5) is also biologically active. Thimet oligopeptidase 1 (also known as EP24.15) cleaves GnRH to form GnRH-(1-5)...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29163130/sex-differences-in-the-cognitive-and-hippocampal-effects-of-streptozotocin-in-an-animal-model-of-sporadic-ad
#12
Jian Bao, Yacoubou A R Mahaman, Rong Liu, Jian-Zhi Wang, Zhiguo Zhang, Bin Zhang, Xiaochuan Wang
More than 95% of Alzheimer's disease (AD) belongs to sporadic AD (sAD), and related animal models are the important research tools for investigating the pathogenesis and developing new drugs for sAD. An intracerebroventricular infusion of streptozotocin (ICV-STZ) is commonly employed to generate sporadic AD animal model. Moreover, the potential impact of sex on brain function is now emphasized in the field of AD. However, whether sex differences exist in AD animal models remains unknown. Here we reported that ICV-STZ remarkably resulted in learning and memory impairment in the Sprague-Dawley male rats, but not in the female rats...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29163051/young-human-cholinergic-neurons-respond-to-physiological-regulators-and-improve-cognitive-symptoms-in-an-animal-model-of-alzheimer-s-disease
#13
Annamaria Morelli, Erica Sarchielli, Giulia Guarnieri, Elisabetta Coppi, Daniela Pantano, Paolo Comeglio, Pamela Nardiello, Anna M Pugliese, Lara Ballerini, Rosanna Matucci, Stefano Ambrosini, Giuseppe Castronovo, Rosa Valente, Benedetta Mazzanti, Sandra Bucciantini, Mario Maggi, Fiorella Casamenti, Pasquale Gallina, Gabriella B Vannelli
The degeneration of cholinergic neurons of the nucleus basalis of Meynert (NBM) in the basal forebrain (BF) is associated to the cognitive decline of Alzheimer's disease (AD) patients. To date no resolutive therapies exist. Cell-based replacement therapy is a strategy currently under consideration, although the mechanisms underlying the generation of stem cell-derived NBM cholinergic neurons able of functional integration remain to be clarified. Since fetal brain is an optimal source of neuronal cells committed towards a specific phenotype, this study is aimed at isolating cholinergic neurons from the human fetal NBM (hfNBMs) in order to study their phenotypic, maturational and functional properties...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29161770/twin-models-of-environmental-and-genetic-influences-on-pubertal-development-salivary-testosterone-and-estradiol-in-adolescence
#14
Andrew D Grotzinger, Frank D Mann, Megan W Patterson, Kathrin Herzhoff, Jennifer L Tackett, Elliot M Tucker-Drob, K Paige Harden
OBJECTIVE: Research on sources of variation in adolescent's gonadal hormone levels is limited. We sought to decompose individual differences in adolescent testosterone, estradiol and pubertal status, into genetic and environmental components. DESIGN: A sample of male and female adolescent twins from the greater Austin and Houston areas provided salivary samples, with a subset of participants providing longitudinal data at two waves. PARTICIPANTS: The sample included 902 adolescent twins, 49% female, ages 13-20 years (M = 15...
November 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29160416/agonistic-activity-of-tamoxifen-a-selective-estrogen-receptor-modulator-serm-on-arthritic-ovariectomized-mice
#15
L A S Silva, F B Felix, J M D Araujo, E V Souza, E A Camargo, R Grespan
Arthritis is positively associated with the decline of sex hormones, especially estrogen. Tamoxifen (TMX) is a selective estrogen receptor modulator, possessing agonist or antagonistic activity in different tissues. Thus, the objective of this study was to investigate the effect of TMX on the zymosan-induced arthritis model. Female Swiss normal and ovariectomized (OVX) mice were divided into groups and treated for five days with TMX (0.3, 0.9 or 2.7 mg/kg) or 17-β-estradiol (E2, 50 µg/kg). On the fifth day, arthritis was induced and 4 h later, leukocyte migration into joint cavities was evaluated...
November 13, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29158795/mismatch-repair-protein-hmlh1-but-not-hmsh2-enhances-estrogen-induced-apoptosis-of-colon-cancer-cells
#16
Peng Jin, De-Zhi Wang, Chen-Xi Lyu, Ya-Ting Wang, Yu-Qi He, Jian-Qiu Sheng, Xuhang Li
BACKGROUND: Epidemiological studies suggest a protective role of estrogen against colon carcinogenesis; this effect appears to be dependent on mismatch repair (MMR) status. However, the underlying mechanism remains unclear. This study investigated the role of MMR proteins in apoptosis of colon cancer cells in the presence or absence of estrogen. METHODS: Two major MMR proteins, human mutL homolog 1 (hMLH1) and mutS homolog 2 (hMSH2), as well as estrogen receptor-β (ERβ), were transiently expressed in either hMLH1-deficient HCT116 cells or hMSH2-deficient LoVo cells...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29157942/expression-of-two-glycoprotein-hormone-receptors-in-larval-parasitic-phase-and-adult-sea-lampreys
#17
Krist N Hausken, Timothy J Marquis, Stacia A Sower
All jawed vertebrates have three canonical glycoprotein hormones (GpHs: luteinizing hormone, LH; follicle stimulating hormone, FSH; and thyroid stimulating hormone, TSH) with three corresponding GpH receptors (GpH-Rs: LH-R, FSH-R and TSH-R). In contrast, we propose that the jawless vertebrate, sea lamprey (Petromyzon marinus), only has two pituitary glycoprotein hormones, lamprey (l)GpH and l-thyrostimulin, and two functional glycoprotein receptors, lGpH-R I and II. It is not known at this time whether there is a specific receptor for lGpH and l-thyrostimulin, or if both GpHs can differentially activate the lGpH-Rs...
November 17, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29156992/evaluation-fucoidan-extracts-from-undaria-pinnatifida-and-fucus-vesiculosus-in-combination-with-anticancer-drugs-in-human-cancer-orthotopic-mouse-models
#18
Maryam Burney, Lata Mathew, Anjali Gaikwad, Elizabeth K Nugent, Anneliese O Gonzalez, Judith A Smith
OBJECTIVE: To determine the activity of fucoidan from Undaria pinnatifida (UPF) and Fucus vesiculosus (FVF) when given in combination of chemotherapy drugs using selected human breast or ovarian cancer orthotopic mouse models. METHODS: Mice were inoculated with 1 × 10(6) cells of TOV-112d, MCF-7, or ZR-75 subcutaneously or SKOV3-GFP-Luc intraperitoneally on day 0. MCF-7 and ZR-75 mice were administered with estradiol valerate 2 mg/kg in 0.2 mL castor oil subcutaneously two days prior to cell inoculation...
November 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29156341/urinary-bisphenol-a-concentrations-are-associated-with-reproductive-parameters-in-young-men
#19
Evdochia Adoamnei, Jaime Mendiola, Fernando Vela-Soria, Mariana F Fernández, Nicolás Olea, Niels Jørgensen, Shanna H Swan, Alberto M Torres-Cantero
Bisphenol A (BPA) is a pervasive environmental toxicant with known reproductive effects on sperm parameters and hormone levels. Several observational studies have investigated the associations between BPA exposure and male reproductive function, but findings are inconsistent. The objective of this study was to assess the associations between urinary BPA concentrations and semen quality and reproductive hormone levels in a cross-sectional study with 215 healthy young university students (18-23 years old), investigated between 2010 and 2011 in Southern Spain (Murcia Region)...
November 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/29155986/prenatal-high-estradiol-exposure-induces-sex-specific-and-dietarily-reversible-insulin-resistance-through-decreased-hypothalamic-insr
#20
Hui-Hui Wang, Cheng-Liang Zhou, Min Lv, Qian Yang, Ju-Xue Li, Min Hou, Jing Lin, Xin-Mei Liu, Yan-Ting Wu, Jian-Zhong Sheng, He-Feng Huang
Adverse intrauterine environment may induce adult disease in offspring, but the mechanisms are not well understood. It is reported that fresh embryo transfer (ET) in assisted reproductive technology presents extra-high maternal estradiol (E2) and prenatal high E2 exposure increases the risk of organ disorders in later life. We found male newborns and children of fresh ET showed increased fasting insulin and the homeostasis model of assessment for insulin resistance index (HOMA-IR). Prenatal high E2 exposed (HE) male mice grew heavier than control and developed insulin resistance, they also showed increased food intake with enhanced orexigenic hypothalamic neuropeptide Y (NPY) expression...
November 15, 2017: Endocrinology
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