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https://www.readbyqxmd.com/read/28346910/occurrence-temporal-variation-and-estrogenic-burden-of-five-parabens-in-sewage-sludge-collected-across-the-united-states
#1
Jing Chen, Benny F G Pycke, Bruce J Brownawell, Chad A Kinney, Edward T Furlong, Dana W Kolpin, Rolf U Halden
Five parabens used as preservatives in pharmaceuticals and personal care products (PPCPs) were measured in sewage sludges collected at 14 U.S. wastewater treatment plants (WWTPs) located in nine states. Detected concentration ranges (ng/g, dry weight) and frequencies were as follows: methyl paraben (15.9 to 203.0; 100%), propyl paraben (0.5 to 7.7; 100%), ethyl paraben (<0.6 to 2.6; 63%), butyl paraben (<0.4 to 4.3; 42%) and benzyl paraben (<0.4 to 3.3; 26%). The estrogenicity inherent to the sum of parabens detected in sewage sludge (ranging from 10...
March 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28346489/gonadotropin-releasing-hormone-receptor-gnrhr-gene-knock-out-normal-growth-and-development-of-sensory-motor-and-spatial-orientation-behavior-but-altered-metabolism-in-neonatal-and-prepubertal-mice
#2
Ellen R Busby, Nancy M Sherwood
Gonadotropin-releasing hormone (GnRH) is important in the control of reproduction, but its actions in non-reproductive processes are less well known. In this study we examined the effect of disrupting the GnRH receptor in mice to determine if growth, metabolism or behaviors that are not associated with reproduction were affected. To minimize the effects of other hormones such as FSH, LH and sex steroids, the neonatal-prepubertal period of 2 to 28 days of age was selected. The study shows that regardless of sex or phenotype in the Gnrhr gene knockout line, there was no significant difference in the daily development of motor control, sensory detection or spatial orientation among the wildtype, heterozygous or null mice...
2017: PloS One
https://www.readbyqxmd.com/read/28345956/modulation-of-steroidogenesis-by-vitamin-d3-in-granulosa-cells-of-the-mouse-model-of-polycystic-ovarian-syndrome
#3
Shabnam Bakhshalizadeh, Fardin Amidi, Ashraf Alleyassin, Masoud Soleimani, Reza Shirazi, Maryam Shabani Nashtaei
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder of women of reproductive age characterized by polycystic ovarian morphology, anovulation or oligomenorrhea, and hyperandrogenism. It is shown that disruption in the steroidogenesis pathway caused by excess androgen in PCOS is a critical element of abnormal folliculogenesis and failure in dominant follicle selection. Vitamin D plays an important role in the regulation of ovulatory dysfunction and can influence genes involved in steroidogenesis in granulosa cells...
March 27, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28345489/primary-culture-of-human-cumulus-cells-requires-stearoyl-coenzyme-a-desaturase-1-activity-for-steroidogenesis-and-enhancing-oocyte-in-vitro-maturation
#4
Shabnam Fayezi, Marefat Ghaffari Novin, Masoud Darabi, Mohsen Norouzian, Mohammad Nouri, Laya Farzadi, Maryam Darabi
Stearoyl-coenzyme A desaturase 1 (SCD1) is a key enzyme in lipid metabolism and is expressed in cumulus cells. The objective of the present study was to evaluate the effect of SCD1 inhibition in human cumulus cells on triglyceride content, steroidogenesis, and oocyte in vitro maturation. Human cumulus cells were exposed to SCD1 inhibitor CAY10566 (SCDinhib) alone or in combination with oleic acid in primary culture. The SCDinhib markedly suppressed triglyceride accumulation (-47%, P = .01), aromatase gene expression (-36%, P = ...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28345469/the-role-of-estradiol-metabolism-in-urogenital-schistosomiasis-induced-bladder-cancer
#5
Nuno Vale, Maria J Gouveia, Gabriel Rinaldi, Júlio Santos, Lúcio Lara Santos, Paul J Brindley, José M Correia da Costa
Urogenital schistosomiasis is a neglected tropical disease that can lead to bladder cancer. How urogenital schistosomiasis induces carcinogenesis remains unclear, although there is evidence that the human blood fluke Schistosoma haematobium, the infectious agent of urogenital schistosomiasis, releases estradiol-like metabolites. These kind of compounds have been implicated in other cancers. Aiming for enhanced understanding of the pathogenesis of the urogenital schistosomiasis-induced bladder cancer, here we review, interpret, and discuss findings of estradiol-like metabolites detected in both the parasite and in the human urine during urogenital schistosomiasis...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28344964/efficacy-and-safety-of-drospirenone-2-mg-17%C3%AE-estradiol-1-mg-hormone-therapy-in-korean-postmenopausal-women
#6
Bo Ra Park, Hye Na Park, Ji Back Jung, Eun Sil Lee, Jeong Sig Kim, Gyu Yeon Choi, Jeong Jae Lee, Im Soon Lee
This regulatory post-marketing surveillance study aimed to evaluate the therapeutic efficacy and safety of drospirenone (DRSP) 2 mg/estradiol (E2) 1 mg tablet in Korean postmenopausal women. A total of 4,149 patients were enrolled and the study was conducted at 207 clinical research centers. The patients' source data was collected between November 2006 and November 2012. More than 85% of patients experienced improvement of menopausal symptoms. The most frequently reported adverse events were vaginal bleeding and breast pain; most of the women suffering from these symptoms fully recovered...
March 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28344192/effect-of-investigational-kisspeptin-metastin-analog-tak-683-on-luteinizing-hormone-secretion-at-different-stages-of-the-luteal-phase-in-goats
#7
Larasati Puji Rahayu, Mohammed El Behiry, Natsumi Endo, Tomomi Tanaka
This study aimed to examine the response of luteinizing hormone (LH) secretion and ovarian steroid profile to TAK-683, an investigational metastin/kisspeptin analog, through treatment during different stages of the luteal phase in goats. Nine cycling Shiba goats (4.4 ± 2.3 years old) were assigned to early luteal phase (ELP, n = 4), mid-luteal phase (MLP, n = 4), and control (n = 5) groups. The ELP and MLP groups were administered 50 µg of TAK-683 intravenously on either day 5 or between days 7-14 after ovulation, respectively...
March 25, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/28342373/using-quantum-chemical-modeling-and-calculations-for-evaluation-of-cellulose-potential-for-estrogen-micropollutants-removal-from-water-effluents
#8
Amin Ghasemi, Milad Asgarpour Khansary, Azam Marjani, Saeed Shirazian
This paper is devoted to investigate the suitability of cellulose for estrogens micropollutants removal from water effluent. For this purpose, the sorption of eight estrogens including Estradiol, Estrone, Testosterone, Progesterone, Estriol, Mestranol, Ethinylestradiol and Diethylstilbestrol were investigated. The charge density profiles and sorption curves were obtained and discussed using quantum chemical calculations where the Accelrys Materials Studio software and COSMO-SAC model were employed. The geometry optimization of compound molecule and energy minimizations was performed using the Dmol3 Module and density functional theory of generalized gradient approximate and Volsko-Wilk-Nusair functional...
March 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28342328/reproductive-toxicity-of-%C3%AE-diketone-antibiotic-mixtures-to-zebrafish-danio-rerio
#9
Xuedong Wang, Yan Ma, Jinfeng Liu, Xiaohan Yin, Zhiheng Zhang, Caihong Wang, Yanyan Li, Huili Wang
So far, few data are available on the reproductive toxicological assessment of β-diketone antibiotics (DKAs), a class of ubiquitous pseudo-persistent pollutant, in zebrafish (Danio rerio). Herein, we reported the reproductive effects of DKAs by means of transcriptome analysis (F1-zebrafish), changes in a series of reproductive indices (F0-zebrafish) and histopathological observations. A total of 1170, 983 and 1399 genes were found to be differentially expressed when compared control vs. 6.25mg/L, control vs...
March 22, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28342046/sources-mechanisms-and-fate-of-steroid-estrogens-in-wastewater-treatment-plants-a-mini-review
#10
Yien Fang Ting, Sarva Mangala Praveena
Steroid estrogens, such as estrone (E1), 17β-estradiol (E2), estriol (E3), and 17α-ethinylestradiol (EE2), are natural and synthetic hormones released into the environment through incomplete sewage discharge. This review focuses on the sources of steroid estrogens in wastewater treatment plants (WWTPs). The mechanisms and fate of steroid estrogens throughout the entire wastewater treatment system are also discussed, and relevant information on regulatory aspects is given. Municipal, pharmaceutical industry, and hospitals are the main sources of steroid estrogens that enter WWTPs...
April 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28341599/nucleo-cytoplasmic-transport-of-estrogen-receptor-alpha-in-breast-cancer-cells
#11
REVIEW
Angeles C Tecalco-Cruz, Issis A Pérez-Alvarado, Josué O Ramírez-Jarquín, Leticia Rocha-Zavaleta
Approximately 70% cases of breast cancers exhibit high expression and activity levels of estrogen receptor alpha (ERα), a transcription regulator that induces the expression of genes associated with cellular proliferation and survival. These nuclear functions of the receptor are associated with the development of breast cancer. However, ERα localization is not static, but rather, dynamic with continuous shuttling between the nucleus and the cytoplasm. Interestingly, both the nuclear import and export of ERα are modulated by several stimuli that include estradiol, antiestrogens, and growth factors...
March 21, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28341582/sex-differences-in-microglial-phagocytosis-in-the-neonatal-hippocampus
#12
Lars H Nelson, Spencer Warden, Kathryn M Lenz
Microglia regulate brain development through many processes, such as promoting neurogenesis, supporting cell survival, and phagocytizing progenitor, newly-born, and dying cells. Many of these same developmental processes show robust sex differences, yet very few studies have assessed sex differences in microglia function during development. Hormonally-induced sexual differentiation of the brain occurs during the perinatal period, thus we examined sex differences in microglial morphology, phagocytosis, and proliferation in the hippocampus during the early postnatal period...
March 21, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28341573/quercetin-alters-uterine-fluid-volume-and-aquaporin-aqp-subunits-aqp-1-2-5-7-expression-in-the-uterus-in-the-presence-of-sex-steroids-in-rats
#13
Huma Shahzad, Nelli Giribabu, Kamarulzaman Karim, Sekaran Muniandy, Normadiah M Kassim, Naguib Salleh
Effects of quercetin on uterine fluid volume and aquaporin (AQP) expression in the uterus were investigated. Estradiol (E) or estradiol followed by progesterone (E+P) were given to ovariectomised rats with or without quercetin (10, 50 or 100mg/kg/day) treatment. Uteri were harvested and its inner/outer circumference ratio was determined. AQP-1, 2, 5 and 7 mRNA and protein levels in uterus were quantified by Real-time PCR and Western blotting respectively. Protein distribution was observed by immunohistochemistry...
March 21, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28341374/cardiorenal-disease-connection-during-post-menopause-the-protective-role-of-estrogen-in-uremic-toxins-induced-microvascular-dysfunction
#14
REVIEW
Jiayi Pei, Magdalena Harakalova, Hester den Ruijter, Gerard Pasterkamp, Dirk J Duncker, Marianne C Verhaar, Folkert W Asselbergs, Caroline Cheng
Female gender, post-menopause, chronic kidney disease (CKD) and (CKD linked) microvascular disease are important risk factors for developing heart failure with preserved ejection fraction (HFpEF). Enhancing our understanding of the interrelation between these risk factors could greatly benefit the identification of new drug targets for future therapy. This review discusses the evidence for the protective role of estradiol (E2) in CKD-associated microvascular disease and related HFpEF. Elevated circulating levels of uremic toxins (UTs) during CKD may act in synergy with hormonal changes during post-menopause and could lead to coronary microvascular endothelial dysfunction in HFpEF...
March 14, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28340262/effect-of-photoperiod-on-serum-hormone-concentrations-during-the-annual-reproductive-cycle-in-geese
#15
X Z Zhao, G L Gao, H W Wang, Q Li, K S Zhang, H Zhong, Q G Wang
The poor egg-laying rate of geese hinders the development of the goose industry; therefore, the reproductive performance of geese is an important area of investigation. To evaluate the relationship between photoperiod, reproductive hormones, and reproductive activity during the egg-laying cycle in geese under natural conditions, we collected blood samples from Sichuan white geese and Xupu geese to quantify changes in prolactin (PRL), estradiol (E2), vasoactive intestinal polypeptide (VIP), follicle stimulating hormone (FSH), gonadotropin-inhibitory hormone (GnIH), and luteinizing hormone (LH)...
March 22, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28339778/effects-of-an-induced-molt-using-cassava-meal-on-body-weight-loss-blood-physiology-ovarian-regression-and-postmolt-egg-production-in-late-phase-laying-hens
#16
N Gongruttananun, P Kochagate, K Poonpan, N Yu-Nun, J Aungsakul, N Sopa
This study was conducted to determine the effect of an induced molt using cassava meal on body weight, blood physiology, ovary, and postmolt performance in late-phase (74 wk old) H&N Brown laying hens. Hens were randomly assigned to 3 treatments of 90 birds each: 1) Controls withno induced molt (CONT); 2) molted by full feeding with cassava meal for 3 wk (FP3); and 3) molted by full feeding with cassava meal for 4 wk (FP4). Groups 2 and 3 were fed a pullet developer diet for 3 wk following treatment. During the molt period, the birds were exposed to an 8L:16D photoperiod and had access to drinking water at all times...
February 23, 2017: Poultry Science
https://www.readbyqxmd.com/read/28339602/gonadotropin-releasing-hormone-kisspeptin-and-gonadal-steroids-directly-modulate-nucleobindin-2-nesfatin-1-in-murine-hypothalamic-gonadotropin-releasing-hormone-neurons-and-gonadotropes%C3%A2
#17
A Hatef, S Unniappan
Neuroendocrine regulation of metabolism and reproduction are tightly interlinked. Nesfatin-1 is an 82 amino acid metabolic peptide derived from nucleobindin-2 (NUCB2). NUCB2 mRNA and protein significantly increase in the hypothalamus of rats during puberty-to-adult transition. Administration of nesfatin-1 modulates circulating LH and testosterone in male rats. However, whether nesfatin-1 acts directly on neurons and gonadotropes remain unknown. In addition, whether reproductive hormones of the hypothalamo-pituitary gonadal axis modulate NUCB2/nesfatin-1 is unclear...
January 28, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28337664/aromatase-expression-in-atypical-ductal-hyperplasia-in-women
#18
R J Santen, D C Radisky, A Degnim, M H Frost, C M Vachon, K Ghosh, F Guestini, K M McNamara, H Sasano
PURPOSE: To determine the levels of aromatase in atypical ductal hyperplasia (ADH) lesions, tissue surrounding the ADH, and in dense and non-dense normal breast tissue. We postulated that excess aromatase in breast tissue might, through production of increased estrogen, drive the carcinogenic process. Estrogens and their metabolites are thought to contribute to the development of breast cancer through estrogen receptor-mediated mechanisms and genotoxic effects of estrogen metabolites...
March 23, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28337462/time-and-dose-dependent-effects-of-17-beta-estradiol-on-short-term-real-time-proliferation-and-gene-expression-in-porcine-granulosa-cells
#19
Sylwia Ciesiółka, Joanna Budna, Karol Jopek, Artur Bryja, Wiesława Kranc, Sylwia Borys, Michal Jeseta, Adrian Chachuła, Agnieszka Ziółkowska, Paweł Antosik, Dorota Bukowska, Klaus P Brüssow, Małgorzata Bruska, Michał Nowicki, Maciej Zabel, Bartosz Kempisty
The key mechanisms responsible for achievement of full reproductive and developmental capability in mammals are the differentiation and transformation of granulosa cells (GCs) during folliculogenesis, oogenesis, and oocyte maturation. Although the role of 17 beta-estradiol (E2) in ovarian activity is widely known, its effect on proliferative capacity, gap junction connection (GJC) formation, and GCs-luteal cells transformation requires further research. Therefore, the goal of this study was to assess the real-time proliferative activity of porcine GCs in vitro in relation to connexin (Cx), luteinizing hormone receptor (LHR), follicle stimulating hormone receptor (FSHR), and aromatase (CYP19A1) expression during short-term (168 h) primary culture...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28336842/sers-based-flavonoid-detection-using-ethylenediamine-%C3%AE-cyclodextrin-as-a-capturing-ligand
#20
Jae Min Choi, Eunil Hahm, Kyeonghui Park, Daham Jeong, Won-Yeop Rho, Jaehi Kim, Dae Hong Jeong, Yoon-Sik Lee, Sung Ho Jhang, Hyun Jong Chung, Eunae Cho, Jae-Hyuk Yu, Bong-Hyun Jun, Seunho Jung
Ethylenediamine-modified β-cyclodextrin (Et-β-CD) was immobilized on aggregated silver nanoparticle (NP)-embedded silica NPs (SiO₂@Ag@Et-β-CD NPs) for the effective detection of flavonoids. Silica NPs were used as the template for embedding silver NPs to create hot spots and enhance surface-enhanced Raman scattering (SERS) signals. Et-β-CD was immobilized on Ag NPs to capture flavonoids via host-guest inclusion complex formation, as indicated by enhanced ultraviolet absorption spectra. The resulting SiO₂@Ag@Et-β-CD NPs were used as the SERS substrate for detecting flavonoids, such as hesperetin, naringenin, quercetin, and luteolin...
January 6, 2017: Nanomaterials
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