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https://www.readbyqxmd.com/read/29319267/kallman-syndrome
#1
N Nand, R Mittal, M Yadav, S Venu, A R Deshmukh
Kallman syndrome (KS) is a rare genetic disorder characterized clinically by failure to attain puberty or failure to fully complete it along with an absent or impaired sense of smell with absence of bilateral olfactory bulbi and sulci alongwith absent olfactory tracts. Only very few cases of Kallman syndrome have been reported in females in Indian population.
October 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29230619/neuroanatomical-and-molecular-correlates-of-cognitive-and-behavioural-outcomes-in-hypogonadal-males
#2
O B Akinola, M O Gabriel
Robust epidemiological, clinical and laboratory evidence supports emerging roles for the sex steroids in such domains as neurodevelopment, behaviour, learning and cognition. Regions of the mammalian brain that are involved in cognitive development and memory do not only express the classical nuclear androgen receptor, but also the non-genomic membrane receptor, which is a G protein-coupled receptor that mediates some rapid effects of the androgens on neurogenesis and synaptic plasticity. Under physiological conditions, hippocampal neurons do express the enzyme aromatase, and therefore actively aromatize testosterone to oestradiol...
December 11, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29105512/changes-in-the-metabolome-and-microrna-levels-in-biological-fluids-might-represent-biomarkers-of-neurotoxicity-a-trimethyltin-study
#3
Syed Z Imam, Zhen He, Elvis Cuevas, Hector Rosas-Hernandez, Susan M Lantz, Sumit Sarkar, James Raymick, Bonnie Robinson, Joseph P Hanig, David Herr, Denise MacMillan, Aaron Smith, Serguei Liachenko, Sherry Ferguson, James O'Callaghan, Diane Miller, Christopher Somps, Ingrid D Pardo, William Slikker, Jennifer B Pierson, Ruth Roberts, Binsheng Gong, Weida Tong, Michael Aschner, Mary J Kallman, David Calligaro, Merle G Paule
Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, and minimally invasive methods to detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid have great potential due to the relative ease of sampling but at present, data on their expression and translation are lacking or inconsistent. In this pilot study using a trimethyl tin rat model of central nervous system toxicity, we have applied state-of-the-art assessment techniques to identify potential individual biomarkers and patterns of biomarkers in serum, plasma, urine or cerebral spinal fluid that may be indicative of nerve cell damage and degeneration...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29105498/can-adipokines-serum-levels-be-used-as-biomarkers-of-hand-osteoarthritis
#4
A Fioravanti, S Cheleschi, A De Palma, O Addimanda, L Mancarella, E Pignotti, L Pulsatelli, M Galeazzi, R Meliconi
PURPOSE: To evaluate serum levels of visfatin, resistin and adiponectin in patients with erosive (E) and non-erosive (NE) osteoarthritis (OA) of the hand (HOA) compared to normal controls (NC). METHODS: 94 outpatients with E HOA and NE HOA and 21 NC were enrolled. The radiological assessment of both hands was performed according to the Kellgren-Lawrence and Kallman score. Patients were divided into two subsets (lone HOA or generalized OA) based on clinically OA involvement of knee and hip...
November 5, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29080672/fezf1-is-a-novel-regulator-of-female-sex-behavior-in-mice
#5
Tomaz Büdefeld, Tanja Spanic, Milka Vrecl, Gregor Majdic
Female sexual behavior is a complex process regulated by multiple brain circuits and influenced by sex steroid hormones acting in the brain. Several regions in the hypothalamus have been implicated in the regulation of female sexual behavior although a complete circuitry involved in female sexual behavior is not understood. Fez family zinc finger 1 (Fezf1) gene is a brain specific gene that has been mostly studied in the context of olfactory development, although in a recent study, FEZF1 has been identified as one of the genes responsible for the development of Kallman syndrome...
November 13, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28949679/benchmark-experiment-for-photoionized-plasma-emission-from-accretion-powered-x-ray-sources
#6
G P Loisel, J E Bailey, D A Liedahl, C J Fontes, T R Kallman, T Nagayama, S B Hansen, G A Rochau, R C Mancini, R W Lee
The interpretation of x-ray spectra emerging from x-ray binaries and active galactic nuclei accreted plasmas relies on complex physical models for radiation generation and transport in photoionized plasmas. These models have not been sufficiently experimentally validated. We have developed a highly reproducible benchmark experiment to study spectrum formation from a photoionized silicon plasma in a regime comparable to astrophysical plasmas. Ionization predictions are higher than inferred from measured absorption spectra...
August 18, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28878825/rna-sequence-data-normalization-through-in-silico-prediction-of-reference-genes-the-bacterial-response-to-dna-damage-as-case-study
#7
Bork A Berghoff, Torgny Karlsson, Thomas Källman, E Gerhart H Wagner, Manfred G Grabherr
BACKGROUND: Measuring how gene expression changes in the course of an experiment assesses how an organism responds on a molecular level. Sequencing of RNA molecules, and their subsequent quantification, aims to assess global gene expression changes on the RNA level (transcriptome). While advances in high-throughput RNA-sequencing (RNA-seq) technologies allow for inexpensive data generation, accurate post-processing and normalization across samples is required to eliminate any systematic noise introduced by the biochemical and/or technical processes...
2017: BioData Mining
https://www.readbyqxmd.com/read/28862321/expression-of-hla-dra-and-cd74-mrna-in-whole-blood-during-the-course-of-complicated-and-uncomplicated-staphylococcus-aureus-bacteremia
#8
Gunlög Rasmussen, Sara Cajander, Anders Bäckman, Jan Källman, Bo Söderquist, Kristoffer Strålin
To improve management of Staphylococcus aureus bacteremia (SAB), better understanding of host-pathogen interactions is needed. In vitro studies have shown that S. aureus bacteria induce dose-dependent immunosuppression that is evidenced by reduced expression of major histocompatibility complex (MHC) class II on antigen presenting cells. Thus, the aim of this study was to determine whether expression of the MHC class II-related genes HLA-DRA and CD74 is more greatly reduced in complicated SAB, with its probable higher loads of S...
October 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28839176/cerium-oxide-nanoparticles-inhibit-differentiation-of-neural-stem-cells
#9
Anda R Gliga, Karin Edoff, Fanny Caputo, Thomas Källman, Hans Blom, Hanna L Karlsson, Lina Ghibelli, Enrico Traversa, Sandra Ceccatelli, Bengt Fadeel
Cerium oxide nanoparticles (nanoceria) display antioxidant properties and have shown cytoprotective effects both in vitro and in vivo. Here, we explored the effects of nanoceria on neural progenitor cells using the C17.2 murine cell line as a model. First, we assessed the effects of nanoceria versus samarium (Sm) doped nanoceria on cell viability in the presence of the prooxidant, DMNQ. Both particles were taken up by cells and nanoceria, but not Sm-doped nanoceria, elicited a temporary cytoprotective effect upon exposure to DMNQ...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28757322/considerations-on-nonclinical-approaches-to-modeling-risk-factors-of-suicidal-ideation-and-behavior
#10
S M G Goody, K E Cannon, M Liu, M J Kallman, J P Martinolle, L Mazelin-Winum, A Giarola, P Ardayfio, J A Moyer, G Teuns, T J Hudzik
Given the serious nature of suicidal ideation and behavior (SIB) and the possibility of treatment-emergent SIB, pharmaceutical companies are now applying more proactive approaches in clinical trials and are considering the value of nonclinical models to predict SIB. The current review summarizes nonclinical approaches to modeling three common risk factors associated with SIB: aggression, impulsivity, and anhedonia. For each risk factor, a general description, advantages and disadvantages, species considerations, nonclinical to clinical translation, and pharmacological validation with respect to treatments associated with SIB are summarized...
July 27, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28619938/kilogram-scale-prexasertib-monolactate-monohydrate-synthesis-under-continuous-flow-cgmp-conditions
#11
Kevin P Cole, Jennifer McClary Groh, Martin D Johnson, Christopher L Burcham, Bradley M Campbell, William D Diseroad, Michael R Heller, John R Howell, Neil J Kallman, Thomas M Koenig, Scott A May, Richard D Miller, David Mitchell, David P Myers, Steven S Myers, Joseph L Phillips, Christopher S Polster, Timothy D White, Jim Cashman, Declan Hurley, Robert Moylan, Paul Sheehan, Richard D Spencer, Kenneth Desmond, Paul Desmond, Olivia Gowran
Advances in drug potency and tailored therapeutics are promoting pharmaceutical manufacturing to transition from a traditional batch paradigm to more flexible continuous processing. Here we report the development of a multistep continuous-flow CGMP (current good manufacturing practices) process that produced 24 kilograms of prexasertib monolactate monohydrate suitable for use in human clinical trials. Eight continuous unit operations were conducted to produce the target at roughly 3 kilograms per day using small continuous reactors, extractors, evaporators, crystallizers, and filters in laboratory fume hoods...
June 16, 2017: Science
https://www.readbyqxmd.com/read/28473760/persistent-effects-of-developmental-exposure-to-17%C3%AE-ethinylestradiol-on-the-zebrafish-danio-rerio-brain-transcriptome-and-behavior
#12
Tove Porseryd, Kristina Volkova, Nasim Reyhanian Caspillo, Thomas Källman, Patrik Dinnetz, Inger Porsh Hällström
The synthetic estrogen 17α-ethinylestradiol (EE2) is an endocrine disrupting compound of concern due to its persistence and widespread presence in the aquatic environment. Effects of developmental exposure to low concentrations of EE2 in fish on reproduction and behavior not only persisted to adulthood, but have also been observed to be transmitted to several generations of unexposed progeny. To investigate the possible biological mechanisms of the persistent anxiogenic phenotype, we exposed zebrafish embryos for 80 days post fertilization to 0, 3, and 10 ng/L EE2 (measured concentrations 2...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27806588/source-modeling-for-monte-carlo-dose-calculation-of-ct-examinations-with-a-radiotherapy-treatment-planning-system
#13
Hans-Erik Källman, Rickard Holmberg, Jonas Andersson, Love Kull, Erik Tranéus, Anders Ahnesjö
PURPOSE: Radiation dose to patients undergoing examinations with Multislice Computed Tomography (MSCT) as well as Cone Beam Computed Tomography (CBCT) is a matter of concern. Risk management could benefit from efficient replace rational dose calculation tools. The paper aims to verify MSCT dose calculations using a Treatment Planning System (TPS) for radiotherapy and to evaluate four different variations of bow-tie filter characterizations for the beam model used in the dose calculations...
November 2016: Medical Physics
https://www.readbyqxmd.com/read/27766822/kallman-syndrome
#14
N Nand, R Mittal, M Yadav, S Venu, A R Deshmukh
Kallman syndrome (KS) is a rare genetic disorder characterized clinically by failure to attain puberty or failure to fully complete it along with an absent or impaired sense of smell with absence of bilateral olfactory bulbi and sulci alongwith absent olfactory tracts. Only very few cases of Kallman syndrome have been reported in females in Indian population.
October 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27749237/mri-and-serum-biomarkers-correlate-with-radiographic-features-in-painful-hand-osteoarthritis
#15
Christian H Roux, Violaine Foltz, Emmanuel Maheu, Gabriel Baron, Frederique Gandjbakhch, Cédric Lukas, Daniel Wendling, Damien Loeuille, Pierre Lafforgue, Liana Euler-Ziegler, Pascal Richette, Xavier Chevalier
OBJECTIVES: To explore the relationship between clinical findings, biologic biomarkers, conventional radiography and MRI in patients with painful hand OA. METHODS: The following patient baseline data from the DORA study (evaluating anti-TNF-α agents against painful hand OA) were used: clinical assessment (pain, swelling, stiffness and function: Dreiser functional hand index [FIHOA] and Cochin hand functional scale [CHFS]); measurement of biomarkers (cartilage oligomeric matrix protein (COMP), type IIA collagen N-propeptid (PIINP), hyaluronic acid (HA), ultrasensitive C-reactive protein (usCRP), tumour necrosis factor (TNF), interleukin (IL)-6, IL-1β and urinary CTXII); radiological staging (Verbruggen, Kallman, Kellgren-Lawrence); anatomical evaluation by contrast-enhanced MRI of proximal and distal interphalangeal joints of dominant hand...
November 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27629024/current-fda-regulatory-guidance-on-the-conduct-of-drug-discrimination-studies-for-nda-review-does-the-scientific-literature-support-recent-recommendations
#16
REVIEW
David V Gauvin, Zachary J Zimmermann, Mary Jeanne Kallman
BACKGROUND: The Controlled Substances Staff of the Center for Drug Evaluation and Research at the US Food and Drug Administration and the Pharmaceutical Research Manufacturers Association (PhRMA) conducted a series of open forum dialog sessions between 2006 and 2016. A Cross Company Abuse Liability Council (CCALC) was formed during the process of this unique collaborative effort between Industry and Federal Regulators whose goals were to establish the development of standards for the preclinical screening of new molecular entities for schedule control actions required as part of every New Drug Application process...
November 1, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27534925/blood-flow-responses-over-sacrum-in-nursing-home-residents-during-one-hour-bed-rest
#17
Ulrika Källman, Sara Bergstrand, Anna-Christina Ek, Maria Engström, Margareta Lindgren
OBJECTIVES: To describe individual blood flow responses in a nursing home resident population for one-hour periods of bed rest. METHODS: Blood flow was measured for one hour over the sacrum in 0° supine position and 30° supine tilt position in 25 individuals aged 65 years or older while lying on a pressure-redistributing mattress. Measurements were made at three tissue depths (1, 2 and 10 mm) using the non-invasive optical techniques LDF and PPG. RESULTS: Eleven participants had a pressure-induced vasodilation (PIV) response at 1 mm depth in both positions and seven participants had a lack of this response at this depth and positions...
August 17, 2016: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/27398775/molecular-orbital-simulations-of-metal-1s2p-resonant-inelastic-x-ray-scattering
#18
Meiyuan Guo, Erik Källman, Lasse Kragh Sørensen, Mickaël G Delcey, Rahul V Pinjari, Marcus Lundberg
For first-row transition metals, high-resolution 3d electronic structure information can be obtained using resonant inelastic X-ray scattering (RIXS). In the hard X-ray region, a K pre-edge (1s→3d) excitation can be followed by monitoring the dipole-allowed Kα (2p→1s) or Kβ (3p→1s) emission, processes labeled 1s2p or 1s3p RIXS. Here the restricted active space (RAS) approach, which is a molecular orbital method, is used for the first time to study hard X-ray RIXS processes. This is achieved by including the two sets of core orbitals in different partitions of the active space...
July 28, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27392065/local-adaptation-in-european-firs-assessed-through-extensive-sampling-across-altitudinal-gradients-in-southern-europe
#19
Louise Brousseau, Dragos Postolache, Martin Lascoux, Andreas D Drouzas, Thomas Källman, Cristina Leonarduzzi, Sascha Liepelt, Andrea Piotti, Flaviu Popescu, Anna M Roschanski, Peter Zhelev, Bruno Fady, Giovanni Giuseppe Vendramin
BACKGROUND: Local adaptation is a key driver of phenotypic and genetic divergence at loci responsible for adaptive traits variations in forest tree populations. Its experimental assessment requires rigorous sampling strategies such as those involving population pairs replicated across broad spatial scales. METHODS: A hierarchical Bayesian model of selection (HBM) that explicitly considers both the replication of the environmental contrast and the hierarchical genetic structure among replicated study sites is introduced...
2016: PloS One
https://www.readbyqxmd.com/read/27354580/the-use-of-complementary-and-alternative-medicine-in-scandinavia
#20
REVIEW
Jonas Nilsson, Mikael Källman, Ulrika Östlund, Georg Holgersson, Michael Bergqvist, Stefan Bergström
BACKGROUND: Complementary alternative medicine (CAM) is widely used among patients with cancer. This usage may have potentially harmful effects, especially when combined with anticancer drugs. However, some complementary methods may benefit patients. This review investigated the prevalence of CAM use among patients with cancer in Scandinavia and secondly studied the educational levels of CAM users compared to non-users. MATERIALS AND METHODS: A systematic search of the PubMed library was carried out to locate articles published between January 2000 and October 2015 that investigated prevalence of CAM use among Scandinavian patients with cancer...
July 2016: Anticancer Research
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