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Mucosa thickness

Vishwanatha R A P Reddy, Ivan Trus, Hans J Nauwynck
Although it has been speculated that the tracheal obstructions and asphyxiation during acute infectious laryngotracheitis (ILT) are due to mucoid plugs/casts formed by mucus hypersecretion, there are no reports demonstrating this. Hence, in the present study, we first examined if the main respiratory mucins, MUC5AC and MUC5B, are expressed in the mucosae of larynx, trachea and bronchi of mock-inoculated and ILTV infected chickens. Second, the tracheas with plugs/casts were stained for mucins (MUC5AC and MUC5B) and nuclear material (traps)...
October 15, 2016: Virus Research
Laila Rashed, Doaa Mostafa Gharib, Rania Elsayed Hussein, Ola Tork, Azza Abusree
AIM: To study the effect of intravenous injection of bone marrow mesenchymal stem cells (BMMSCs), alone and combined with NO inducer in gastric ulcer healing in a rat model. METHODS: Rats were divided into controls, gastric ulcer, gastric ulcer receiving mesenchymal stem cells (MSCs), gastric ulcer receiving NO inducer (l-Arginine), gastric ulcer receiving MSCs plus NO inducer (l-Arginine) groups. MSCs were given in a dose of (10(6)cells) by intravenous injection...
September 28, 2016: Tissue & Cell
Julia Hehn, Thomas Schwenk, Markus Striegel, Markus Schlee
BACKGROUND: Previous studies have shown that adequate thickness or initial augmentation of soft tissue has a positive effect on the stability of peri-implant bone. This randomized, controlled trial aimed to evaluate the influence of augmenting soft tissue with platelet-rich fibrin (PRF) on crestal bone and soft tissue around implants. METHODS: After randomization, 31 fully threaded titanium implants were inserted in 31 patients (16 men and 15 women) in the lower mandible using a split-flap technique...
December 2016: Int J Implant Dent
Daisuke Ueno, Jayanetti Asiri Jayawardena, Takashi Kurokawa
Soft tissue dehiscence around dental implant has frequently been observed and it may lead to poor oral hygiene, especially around crowns that exhibit contours with prominent convexity. The present case demonstrates a peri-implant mucosal dehiscence coverage with modified semilunar coronary positioned flap (CPF) in #15 and 16. A semilunar partial-thickness incision was performed 7-10 mm apical from the facial gingival margin. Then, intrasulcular partial-thickness incision was tunneled to the semilunar incision...
December 2015: Int J Implant Dent
Hyun Jin Shin, Kyung In Woo, Yoon-Duck Kim
OBJECTIVE: To determine the factors associated with rhinostomy shape after endoscopic dacryocystorhinostomy (DCR) in patients with primary acquired nasolacrimal duct obstruction. DESIGN: Retrospective comparative study. SETTING: University hospital. PARTICIPANTS: 102 cases in 70 patients were included in the study. MAIN OUTCOME MEASURE: All cases were classified into three groups according to the healed appearance of the rhinostomy: flat, ladle, and ice scoop type...
October 11, 2016: Clinical Otolaryngology
Sunki Rhee, Masahito Yamamoto, Kei Kitamura, Kasahara Masaaki, Yukio Katori, Gen Murakami, Shin-Ichi Abe
Macrophages play an important role in aging-related muscle atrophy (i.e., sarcopenia). We examined macrophage density in six striated muscles (cricopharyngeus muscle, posterior cricoarytenoideus muscle, genioglossus muscle, masseter muscle, infraspinatus muscle, and external anal sphincter). We examined 14 donated male cadavers and utilized CD68 immunohistochemistry to clarify macrophage density in muscles. The numbers of macrophages per striated muscle fiber in the larynx and pharynx (0.34 and 0.31) were 5-6 times greater than those in the tongue, shoulder, and anus (0...
September 2016: Anatomy & Cell Biology
Kouji Katsura, Satoru Utsunomiya, Eisuke Abe, Hironori Sakai, Naotaka Kushima, Satoshi Tanabe, Takumi Yamada, Takahide Hayakawa, Yoshihiko Yamanoi, Syuhei Kimura, Shinichi Wada, Hidefumi Aoyama, Takafumi Hayashi
The changes in dose distribution caused by backscatter radiation from a common commercial dental alloy (Au-Ag-Pd dental alloy; DA) were investigated to identify the optimal material and thicknesses of a dental device (DD) for effective prevention of mucositis. To this end, 1 cm(3) of DA was irradiated with a 6-MV X-ray beam (100 MU) in a field size of 10 × 10 cm(2) using a Novalis TX linear accelerator. Ethylene vinyl acetate copolymer, polyolefin elastomer, and polyethylene terephthalate (PET) were selected as DD materials...
October 4, 2016: Journal of Radiation Research
Margot Den Hondt, Bart M Vanaudenaerde, Erik K Verbeken, Jan J Vranckx
BACKGROUND: Successful trachea transplantation comprises the use of biocompatible constructs with little immune-reactivity, submucosal revascularization and creation of an epithelial covering. Allogenic chondrocytes might be protected from an overt immune-response due to physical isolation. Our aim was to evaluate in-vivo biocompatibility of allotracheae, stripped of their highly-immunogenic inner lining. Secondly, we established whether these constructs might serve as suitable scaffolds for autologous epithelial grafting...
October 4, 2016: Acta Chirurgica Belgica
Renu Parmar, Vijay Reddy, Satheesh Kumar Reddy, Deepti Reddy
INTRODUCTION: A wide variety of factors affect the success of orthodontic miniscrews in clinical situations, including thickness of the soft tissues. Our objectives were to assess area-related and sex-related differences in the soft tissue thicknesses of the buccal attached gingiva of the maxilla and the mandible, and the palatal masticatory mucosa at common orthodontic miniscrew placement sites, and to prescribe a guideline for miniscrew selection for a predictable clinical outcome. METHODS: The sample consisted of 32 randomly selected adults in the age group of 20 to 25 years...
October 2016: American Journal of Orthodontics and Dentofacial Orthopedics
Sharon J Akrish, Adi Rachmiel, Edmond Sabo, Marilena Vered, Ofer Ben-Izhak
BACKGROUND: Cancer-associated fibroblasts (CAFs) are generally associated with negative prognostic factors. This study compares the clinicopathologic impact of CAFs in oral squamous cell carcinoma in patients with a history of proliferative verrucous leukoplakia (p-scca) and patients with conventional squamous cell carcinoma of the buccal mucosa, gingiva, and palate (c-scca). METHODS: A retrospective clinicopathologic and immunohistochemical analysis of 97 tumor specimens from 78 patients (13 patients with proliferative verrucous leukoplakia-associated squamous cell carcinoma (n = 32) and conventional squamous cell carcinoma from the buccal mucosa, gingiva, and palate (n = 65) was conducted...
September 29, 2016: Journal of Oral Pathology & Medicine
Minoru Sanda, Makoto Shiota, Chiharu Imakita, Aoi Sakuyama, Shohei Kasugai, Yasunori Sumi
PURPOSE: Optical coherence tomography (OCT) has been investigated as a novel diagnostic imaging tool. The utilisation of this equipment has been evaluated through several studies in the field of dentistry. The aim of this preliminary study was to determine through basic experiments the effectiveness of OCT in implant dentistry. MATERIALS AND METHODS: To assess detection ability, we captured OCT images of implants in each of the following situations: (1) implants covered with mucosae of various thicknesses that were harvested from the mandibles of pigs; (2) implants installed in the mandibles of pigs; and (3) implants with abutments and crowns fixed with temporary cement...
September 2016: Imaging Science in Dentistry
Brian A Neff, Stephen G Voss, Matthew L Carlson, Erin K O'Brien, Joseph H Butterfield
OBJECTIVE/HYPOTHESIS: Eosinophilic otitis media (EOM) is a variant of chronic otitis media that is characterized by the development of thick mucoid middle ear effusion, adult onset bronchial asthma, sinonasal polyposis, and aspirin sensitivity. EOM is typically refractory to corticosteroid therapy and surgical intervention. Pegylated interferon (PEG-IFN) has effectively treated hypereosinophilic syndrome in clinical trials; however, the efficacy of this medication for EOM treatment remains undefined...
September 26, 2016: Laryngoscope
Cuneyd Sevinc, Muhsin Balaban, Orkunt Ozkaptan, Necmettin Kutlu, Tahir Karadeniz
The aim of this study was to describe a technique using full-thickness skin grafts (FTSGs) from different parts of the body for salvage urethroplasties and the present outcomes. A total of 24 men underwent urethroplasties for strictures averaging 7.7 cm (range, 5-17 cm) in length, using FTSGs from the inner arm, inner thigh, or abdominal skin. Each of these cases had at least one failed urethroplasty. Twenty-four patients underwent surgery for 26 urethral strictures, with a mean follow-up period of 23.2 (5-44) months and a mean operation time of 140 (115-180) minutes...
September 2016: Kaohsiung Journal of Medical Sciences
Kapil S Agrawal, Raghav Shrotriya, Mansi Pabari
Loss of columella is a significant deformity and its reconstruction proves to be quite difficult. An 18-year-old lady had loss of columella due to burn while steam inhalation at a young age and required reconstruction for the same. Labial mucosa has been used as a source of tissue for columellar reconstruction since long. We describe a modification of the buccal mucosal flap to manage a difficult case of columellar deficiency. The buccal mucosa flap was used to cover the columellar defect in the usual manner in the first stage and in second stage, along with division of the base, the residual length of the mucosal flap was used to add to the thickness of columella by doubling it on itself...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
Aya Kamaya, Pauline Chang Yu, Carla Ramas Lloyd, Bertha H Chen, Terry S Desser, Katherine E Maturen
OBJECTIVES: To evaluate the interrupted mucosa sign for identification of endometrial polyps, using pathologic confirmation as the reference standard, compared to other accepted sonographic findings. METHODS: We reviewed 195 patients referred for pelvic sonographic evaluations for suspected endometrial polyps in this retrospective Institutional Review Board-approved study. Of these, 82 had tissue sampling of the endometrium and constituted the final study group...
September 14, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Verônica Santana de Freitas-Blanco, Michelle Franz-Montan, Francisco Carlos Groppo, João Ernesto de Carvalho, Glyn Mara Figueira, Luciano Serpe, Ilza Maria Oliveira Sousa, Viviane Aparecida Guilherme Damasio, Lais Thiemi Yamane, Eneida de Paula, Rodney Alexandre Ferreira Rodrigues
PURPOSE: To develop an anesthetic mucoadhesive film containing Acmella oleracea (jambu) extract for topical use on oral mucosa. METHODS: Ethanolic extracts from aerial parts of jambu were prepared by maceration. Pigment removal was obtained by adsorption with activated carbon. Three mucoadhesive films were developed using a film casting method: 10 or 20% of crude jambu extract (10% JB and 20% JB), and 10% of crude jambu extract treated with activated carbon (10% JBC)...
2016: PloS One
Takao Hara, Tsuyoshi Etoh, Yoshitake Ueda, Yuki Shitomi, Hidefumi Shiroshita, Norio Shiraishi, Tsutomu Daa, Masafumi Inomata
BACKGROUND: Endoscopic resection is accepted as the standard treatment for early mucosal gastric cancer, and its indications have recently been expanded while its long-term outcomes are still unclear. Herein, we present a didactic case of undifferentiated-type mucosal gastric cancer fulfilling the expanded indication and curative criteria for endoscopic submucosal dissection (ESD), having synchronous multiple lymph node metastases. CASE PRESENTATION: A 40-year-old woman was found to have a Helicobacter pylori infection at a standard health check with no abdominal symptoms...
December 2016: Surgical Case Reports
Ji Eun Kim, Jun Go, Eun Kyoung Koh, Sung Hwa Song, Ji Eun Sung, Hyun Ah Lee, Young Hee Lee, Jin Tae Hong, Dae Youn Hwang
Several natural products containing tannins are used as traditional medicines for treatment of constipation; however, their pharmacological mechanism is not well understood. The laxative effects of gallotannin-enriched extract isolated from Galla Rhois (GEGR) were investigated using a constipation model induced by loperamide (Lop) injection. After analysis for antioxidant activity of GEGR, alterations in the excretion parameters, histological structure, mucin secretion, and related protein levels were measured in the transverse colon of Sprague Dawley (SD) rats with Lop-induced constipation following treatment with 250, 500 and 1,000 mg/ml of GEGR...
2016: PloS One
M A Martín-Piedra, M Alaminos, R Fernández-Valadés-Gámez, A España-López, E Liceras-Liceras, I Sánchez-Montesinos, A Martínez-Plaza, M C Sánchez-Quevedo, R Fernández-Valadés, I Garzón
Current tissue engineering technology focuses on developing simple tissues, whereas multilayered structures comprising several tissue types have rarely been described. We developed a highly biomimetic multilayered palate substitute with bone and oral mucosa tissues using rabbit cells and biomaterials subjected to nanotechnological techniques based on plastic compression. This novel palate substitute was autologously grafted in vivo, and histological and histochemical analyses were used to evaluate biointegration, cell function, and cell differentiation in the multilayered palate substitute...
September 6, 2016: Histochemistry and Cell Biology
Thomas G Beach, Anne-Gaëlle Corbillé, Franck Letournel, Jeffrey H Kordower, Thomas Kremer, David G Munoz, Anthony Intorcia, Joseph Hentz, Charles H Adler, Lucia I Sue, Jessica Walker, Geidy Serrano, Pascal Derkinderen
BACKGROUND: Conflicting results from studies of Lewy-type α-synucleinopathy (LTS) in colonic biopsies of subjects with Parkinson's disease (PD) prompted a two-part multicenter assessment. The first assessment, now published (Acta Neuropathol Commun 4 : 35, 2016), examined archived colonic biopsies and found that none of the tested methods was adequately sensitive or specific. OBJECTIVE: As the amount of nervous tissue in typical colonic biopsies may be insufficient, and the clinical diagnosis of PD not completely accurate, the objective of the current study was to use instead full-thickness sections of sigmoid colon from autopsy-proven PD and normal subjects...
October 19, 2016: Journal of Parkinson's Disease
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