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https://www.readbyqxmd.com/read/29160624/buccal-patches-of-atenolol-formulated-using-fenugreek-trigonella-foenum-graecum-l-seed-mucilage
#1
Surya Narayan Ratha Adhikari, Satyabrata Panda
BACKGROUND: The use of mucoadhesive natural polymers in designing mucoadhesive patch systems has received much attention. OBJECTIVES: The study involved the development and evaluation of buccal patches of atenolol using fenugreek (Trigonella foenum-graecum L.) seed mucilage with hydroxylpropyl methyl cellulose (HPMC K4M) and a backing membrane (ethyl cellulose 5% w/v). MATERIAL AND METHODS: These atenolol-releasing buccal patches were prepared using a solvent casting technique...
January 2017: Polimery W Medycynie
https://www.readbyqxmd.com/read/29154086/mechanical-characterization-of-in-vitro-formed-short-term-salivary-pellicle
#2
Yafeng Zhang, Jing Zheng, Jiaxin Yu, Hongtu He
Human saliva consists of approximately 98% water and a variety of electrolytes and proteins. Those proteins can be selectively adsorbed onto the enamel surface. The cuticular material formed on the enamel surface is termed acquired salivary pellicle (ASP), which is critical for the health of oral mucosa and teeth. The ASP is composed of a inner layer and a outer layer. The lubricating properties of ASP are closely associated with the inner layer. The aim of this research is to characterize the structural and mechanical properties of the inner layer of ASP...
November 7, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29150404/stress-hormones-concentrations-in-the-normal-microenvironment-predict-risk-for-chemically-induced-cancer-in-rats
#3
Vitor Bonetti Valente, Flávia Alves Verza, Felipe Yudi Kabeya Lopes, Joana Zafalon Ferreira, Paulo Sérgio Patto Dos Santos, Maria Lúcia Marçal Mazza Sundefeld, Éder Ricardo Biasoli, Glauco Issamu Miyahara, Ana Maria Pires Soubhia, Mariza de Andrade, Sandra Helena Penha de Oliveira, Daniel Galera Bernabé
Evidence show that stress hormones can influence cancer progression, but its role in carcinogenesis is poorly understood. In this study, we used a new method based on oral carcinogenesis model in rats to test the hypothesis that physiological levels of stress hormones in the normal tissue microenvironment would have significant predictive value for chemically induced cancer occurrence. Male Wistar rats were submitted to a tongue biopsy for measuring not-stress induced levels of norepinephrine, corticosterone, adrenocorticotropic hormone (ACTH) and brain-derived neurotrophic factor (BDNF) in the tissue before carcinogenic induction...
November 8, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29145318/an-unusual-cause-of-fever-of-unknown-origin-with-enlarged-lymph-nodes-relapsing-polychondritis-a-case-report
#4
Wei Liu, Hongli Jiang, Han Jing, Bing Mao
INTRODUCTION: Fever of unknown origin (FUO) is a common initial presentation leading to a diagnostic challenge. PATIENT CONCERNS: A 3-month history of moderate-to-high fever was reported in an otherwise healthy 54-year-old man. Enhanced computed tomography (CT) scans of his chest showed a remarkable progressive enlargement of bilateral cervical, supraclavicular, hilar, and mediastinal lymph nodes within 2 weeks. Bronchofibroscopy manifested obvious luminal stenosis with swelling, thick pale mucosa, and disappearing of structures of trachea cricoid cartilage, followed by a 18F-fluorodeoxyglucose positron-emission tomography-computed tomography (18F-FDG PET/CT) with intense symmetric FDG uptake in larynx, tracheobronchial tree, and hilar, mediastinal, and axillary lymph nodes being demonstrated...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143087/factors-associated-with-premalignant-epithelial-changes-in-chronic-calculous-cholecystitis-a-case-control-study
#5
Muhibullah Bangash, Abdul Rehman Alvi, Noman Shahzad, Amir Hafeez Shariff, Roger Christopher Gill
INTRODUCTION: Gallstones are known to be associated with premalignant changes in the gallbladder epithelium that range from atypical hyperplasia, metaplasia, dysplasia to carcinoma. Recognition of factors associated with these changes in patients with gallstones can potentially be helpful in identifying patients to whom prophylactic cholecystectomy can be offered to reduce the chances of developing carcinoma. OBJECTIVE: To identify factors associated with premalignant epithelial changes including atypical hyperplasia, metaplasia, and dysplasia in gallbladder mucosa in patients with chronic calculus cholecystitis...
November 15, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29133658/role-of-amniotic-membrane-and-full-thickness-skin-graft-in-reconstruction-of-kissing-nevus-of-eyelids
#6
Manpreet Singh, Natasha Gautam, Manpreet Kaur, Zoramthara Zadeng
A 20-year-old girl presented with a large pigmented lesion over the temporal aspect of left lateral canthus involving the lateral one-third of both eyelids, since birth. A slow increase in its size had been noticed for the past 2 years. On examination, a hairy nevus measuring 34 mm × 22 mm was noticed involving left eyelid skin, the mucocutaneous junction (MCJ), palpebral conjunctiva, and lateral canthus. The surface was irregularly thick and covered with long, thick, and pigmented hairs. A clinical diagnosis of kissing nevus of eyelids was kept and a surgical resection with reconstruction planned...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29132736/clinical-effects-of-probiotics-in-cystic-fibrosis-patients-a-systematic-review
#7
Stephanie Van Biervliet, Dimitri Declercq, Shawn Somerset
Cystic fibrosis (CF) is characterised by a build-up of thick, intransient mucus linings of the digestive and respiratory mucosa, which disrupts digestive system functioning and microbiota composition. In view of the potential for probiotics to enhance microbiota composition in other contexts, this study investigated the current evidence for probiotics as an adjunct to usual therapy for CF. Electronic clinical databases were interrogated for human randomised, controlled, intervention trials (1985-2015) testing the effects of probiotics on clinical endpoints in CF were reviewed...
April 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29132484/abdominal-ct-findings-in-patients-with-primary-lymphoma-causing-small-bowel-obstruction
#8
Elif Karadeli, Gurcan Erbay, Alper Parlakgumus, Hakan Yabanoglu
The purpose of this study was to investigate retrospectively CTfindings in patients with primary lymphoma causing small bowel obstruction. CTscans of 11 patients with small bowel lymphoma were separately analysed in terms of affected section of the small bowel, focality, wall thickness, pattern and degree of contrast enhancement, lymphadenopathy, organ involvement, perforation, and the presence of intraabdominal fluid. Eight patients had diffuse large B-cell lymphoma, and one patient each had marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT), T-cell lymphoma, and anaplastic T-cell lymphoma...
November 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29110144/new-formulation-and-approach-for-mucoadhesive-buccal-film-of-rizatriptan-benzoate
#9
Sahar Salehi, Soheil Boddohi
Mucoadhesive buccal film is developed as a promising dosage form, which has prominent advantages because of drug delivery through buccal mucosa. New formulation of buccal films containing rizatriptan benzoate (RB) was prepared by solvent casting method using various concentrations of hydroxypropyl methylcellulose (HPMC K4M), polyvinyl alcohol (PVA), polyethylene oxide (PEO), glycerol, stevia, and goat buccal mucosa used as a model membrane. In this work, the effect of polymers and plasticizer concentrations on drug release profile, disintegration and dissolution time, mechanical properties, and mucoadhesive characteristics of films was studied...
November 6, 2017: Progress in biomaterials
https://www.readbyqxmd.com/read/29107123/use-of-buccal-fat-pads-to-prevent-vestibular-gingival-recession-of-zygomatic-implants
#10
P Guennal, J Guiol
Zygomatic implants can be used for dental rehabilitation in atrophic maxillae. This allows for maxillary grafts to be avoided while also permitting immediate functional use. Initially, the implants had a palatal emergence. The surgical technique has undergone continuous development and the implants are now sometimes extra-maxillary in order to better match with the prosthetic space. The main risk is vestibular exposure of the implant as a gingival recession caused by mucositis or peri-implantitis. When the first patients exhibited this problem, the authors sought a solution in order to prevent this complication from occurring...
November 3, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29101717/ileal-transposition-it-surgery-changing-the-ultrastructure-of-the-transposed-segment-as-well-as-jejunum-histomorphometric-and-electron-microscopy-analysis
#11
Tomasz Sawczyn, Julia Zimmermann, Dominika Stygar, Michał Kukla, Katarzyna Nabrdalik, Natalia Matysiak, Łukasz Mielańczyk, Konrad Wojciech Karcz
OBJECTIVE: Ileal transposition (IT) procedure leads to higher secretion of incretin hormones what is associated with a beneficial metabolic effect. However, IT will also have an influence on the related jejunum and ileum function. The aim of this research was to investigate the morphology of the jejunum and transposed ileum with the use of light and transmission electron microscopy (TEM) in order to determine the local alternations in the intestine resulting from the transposition. METHODS: Twenty male, 8-week-old, obese Zucker rats underwent IT and six of them sham surgery...
November 3, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29101561/non-exposure-simple-suturing-endoscopic-full-thickness-resection-ness-eftr-versus-laparoscopic-wedge-resection-a-randomized-controlled-trial-in-a-porcine-model
#12
Hong Man Yoon, Chan Gyoo Kim, Jong Yeul Lee, Soo-Jeong Cho, Myeong-Cherl Kook, Bang Wool Eom, Keun Won Ryu, Young-Woo Kim, Il Ju Choi
BACKGROUND: Current endoscopic full-thickness resection (EFTR) methods produce transmural communication and expose the tumor to the peritoneum. An EFTR method with a simple suturing technique that does not expose the gastric mucosa to the peritoneum (non-exposure simple suturing, NESS) was recently developed. To date, there have been no prospective studies that compare EFTR with laparoscopic wedge resection in human or animal. The aim of this study was to compare outcomes between NESS-EFTR and laparoscopic wedge resection (LWR) using the linear staplers in a randomized animal study...
November 3, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29090206/reconstruction-of-the-three-dimensional-mandibulofacial-defects-using-a-single-cutaneous-perforator-based-fibula-osteocutaneous-flap
#13
In Sook Kang, Jun Gul Ko, Ji Seon Choi, Jin Soo Lim, Min Cheol Kim
The reconstruction of the mandibulofacial defects is a difficult task when there are full-thickness cheek defects involving mandible, inner mucosa and outer skin. There are several reconstructive options for the coverage of large defects, but most of the methods are complicated, and time- and effort-consuming. We hereby present a case of fibula osteocutaneous flap based on a single peroneal artery perforator in the reconstruction of a three-dimensional mandibulofacial defects.
September 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/29077918/the-interactive-effect-of-dietary-n-6-%C3%A2-n-3-fatty-acid-ratio-and-vitamin-e-level-on-tissue-lipid-peroxidation-dna-damage-in-intestinal-epithelial-cells-and-gut-morphology-in-chickens-of-different-ages
#14
P Konieczka, M Barszcz, M Choct, S Smulikowska
Feeding chickens diets high in n-3 fatty acids (FA) increases their incorporation into tissue lipids, but leads to oxidative stress in cells. This study investigated the effect of the dietary polyunsaturated FA ratio (PUFA n-6: n-3) and vitamin E (vE) level on DNA damage and morphological changes in the gut epithelium of chickens. One-day-old female broiler chicks (n = 176) were divided into 4 groups fed for 43 d diets with a high (HR) or low (LR) PUFA n-6: n-3 ratio and supplemented with 50 or 300 mg vE kg-1...
October 25, 2017: Poultry Science
https://www.readbyqxmd.com/read/29072240/the-role-of-the-nasal-and-paranasal-sinus-pathologies-on-the-development-of-chronic-otitis-media-and-its-subtypes-a-computed-tomography-study
#15
M Damar, A E Dinç, D Erdem, S Bişkin, S Ş Eliçora, Y Ç Kumbul
OBJECTIVE: This objective of this study is to evaluate the presence and the coincidence of common nasal and paranasal sinus pathologies in adults suffering from chronic otitis media (COM) and its subtypes. MATERIALS AND METHODS: The study group comprised 354 ears of 177 patients who underwent tympanoplasty with or without mastoidectomy from January 2013 to February 2015 due to uni/bilateral COM. Chronic suppurative otitis media, intratympanic tympanosclerosis (ITTS), cholesteatoma, and tympanic membrane with retraction pockets constituted subtypes of COM...
September 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29071227/formulation-and-optimization-of-oral-mucoadhesive-patches-of-myrtus-communis-by-box-behnken-design
#16
Mahbubeh Hashemi, Vahid Ramezani, Mohammad Seyedabadi, Ali Mohamad Ranjbar, Hossein Jafari, Mina Honarvar, Hamed Fanaei
Purpose: Recurrent aphthous stomatitis (RAS) is the most common painful ulcerative disease of oral mucosa happening in ~20% of people. Aimed to develop Myrtus communis L. (Myrtle) containing oral patches, we applied box-behnken design to evaluate the effect of polymers such as Polyvinyl pyrrolidone (PVP), Gelatin, Methylcellulose (MC) and Pectin. Methods: The patches properties such as tensile strength, folding endurance, swelling index, thickness, mucoadhesive strength and the pattern of myrtle release were evaluated as dependent variables...
September 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29069891/additive-effects-of-rebamipide-plus-proton-pump-inhibitors-on-the-expression-of-tight-junction-proteins-in-a-rat-model-of-gastro-esophageal-reflux-disease
#17
Tae-Geun Gweon, Jong-Hyung Park, Byung-Wook Kim, Yang Kyu Choi, Joon Sung Kim, Sung Min Park, Chang Whan Kim, Hyung-Gil Kim, Jun-Won Chung
Background/Aims: The aim of this study was to investigate the effects of rebamipide on tight junction proteins in the esophageal mucosa in a rat model of gastroesophageal reflux disease (GERD). Methods: GERD was created in rats by tying the proximal stomach. The rats were divided into a control group, a proton pump inhibitor (PPI) group, and a PPI plus rebamipide (PPI+R) group. Pantoprazole (5 mg/kg) was administered intraperitoneally to the PPI and PPI+R groups...
October 27, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29068034/characterization-of-fecal-fat-composition-and-gut-derived-fecal-microbiota-in-high-fat-diet-fed-rats-following-intervention-with-chito-oligosaccharide-and-resistant-starch-complexes
#18
Wenting Shang, Xu Si, Zhongkai Zhou, Ying Li, Padraig Strappe, Chris Blanchard
The current study analyzed the different effects of intervention in high-fat diet fed rats using chito-oligosaccharides (CO group), resistant starch (RS group) and their complexes (CO-RS group), respectively. Properties such as fecal fat composition, gut derived fecal microbiota and fecal metabolites were investigated. The results show that supplementation with CO-RS in the high-fat diet led to the highest level of fecal fat excretion, followed by the CO and RS groups, and its fatty acid composition was characterized by a lower ∑UFA and higher ∑SFA levels...
October 25, 2017: Food & Function
https://www.readbyqxmd.com/read/29060905/effects-of-nd-yag-laser-for-the-controlled-and-localized-treatment-of-early-gastrointestinal-tumors-preliminary-in-vivo-study
#19
P Saccomandi, G Quero, G Costamagna, M Diana, J Marescaux
Endoscopic submucosal dissection (ESD) is a minimally invasive technique allowing for the removal of early gastrointestinal (GI) tumors, widely considered as a valid alternative to conventional surgery. However, ESD is technically demanding, and potentially severe complications, such as bleeding and perforation, may occur. Energy-based techniques (e.g., radiofrequency ablation) might offer a potential alternative to ESD. However, their use mandates the ability to predict the damage induced and to identify a "signature" of the complete ablation, without the need for a physical specimen...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29043576/submucosal-tunneling-endoscopic-resection-for-the-treatment-of-gastrointestinal-submucosal-tumors-originating-from-the-muscularis-propria-layer
#20
Chen Du, Enqiang Linghu
Surgical resection and endoscopic resection comprise two alternative options for the treatment of submucosal tumors (SMTs) originating from the muscularis propria (MP) layer. Endoscopic resection is minimally invasive compared with surgical resection. Conventional non-tunneling techniques, such as endoscopic submucosal dissection (ESD), endoscopic submucosal excavation (ESE), and endoscopic full-thickness resection (EFR) have been demonstrated to be safe and effective. However, these techniques fail to maintain the integrity of the mucosa and induce high risk of perforation, infection, and postoperative strictures...
October 17, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
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