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https://www.readbyqxmd.com/read/28629000/formulation-and-in-vitro-efficacy-of-antifungal-mucoadhesive-polymeric-matrices-for-the-delivery-of-miconazole-nitrate
#1
G Tejada, G N Piccirilli, M Sortino, C J Salomón, M C Lamas, D Leonardi
Oral candidiasis is the most common opportunistic infection affecting patients with the human immunodeficiency virus. Miconazole buccal tablets or miconazole gel are approved for the treatment of oropharyngeal candidiasis. However, buccal films present more flexibility and also offer protection for the wounded mucosa, reducing pain. Due to their small size and thickness, buccal films may improve patients' compliance, compared to tablets. Additionally, they may increase the relatively short residence time on the mucosa of oral gels, which are easily removed by saliva...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28625071/adult-gastric-duplication-an-unknown-condition-within-the-spectrum-of-gastric-submucosal-lesions
#2
Yurena Caballero Díaz, Macarena Centeno Haro, Ángel Turégano García, Juan Ramón Hernández Hernández
Gastric duplication is an uncommon condition in adults representing only 4-8% of all gastrointestinal duplications. It develops as a cystic growth within the thick gastric wall that is surrounded by a layer of smooth muscle and lined with gastric mucosa. It is usually asymptomatic but may present with nonspecific abdominal symptoms as well as cyst-related complications such as gastrointestinal (GI) bleeding, ulceration and even pancreatitis. They are difficult to distinguish from other gastric submucosal lesions and may also mimic a gastrointestinal tumor (GIST) or mucinous cyst of the pancreas...
June 19, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28620637/evaluation-of-the-effects-of-three-plant-species-myrtus-communis-l-camellia-sinensis-l-zataria-multiflora-boiss-on-the-healing-process-of-intraoral-ulcers-in-rats
#3
Maryam Alsadat Hashemipour, Sodabeh Lotfi, Molok Torabi, Fariba Sharifi, Mehdi Ansari, Amirreza Ghassemi, Saied Sheikhshoaie
STATEMENT OF THE PROBLEM: Use of traditional medicine to relieve human sufferings has a very long history. The effects of these plants in wound curing and subsequently making the best mucosa patch for treatment of oral ulcers is still under investigation. PURPOSE: The main goal of present research work is to assess the efficacy of Myrtus communis L., Camellia sinensis L. and Zataria multiflora Boiss. on oral ulcer recovery process in rats. MATERIALS AND METHOD: In this study, 60 healthy adult male rats in 5 groups were investigated...
June 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28619727/rna-seq-implicates-deregulation-of-the-immune-system-in-the-pathogenesis-of-diverticulitis
#4
Kathleen M Schieffer, Christine S Choi, Scott Emrich, Leonard Harris, Sue Deiling, Dipti M Karamchandani, Anna Salzberg, Yuka I Kawasawa, Gregory S Yochum, Walter A Koltun
Individuals with diverticula or outpouchings of the colonic mucosa and submucosa through the colonic wall have diverticulosis, which is usually asymptomatic. In 10-25% of individuals, the diverticula become inflamed, resulting in diverticulitis. Very little is known about the pathophysiology or gene regulatory pathways involved in the development of diverticulitis. To identify these pathways, we deep sequenced RNAs isolated from full-thickness sections of sigmoid colon from diverticulitis patients and control individuals...
June 15, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28610687/assessing-the-thickness-of-the-vaginal-wall-and-vaginal-mucosa-in-pre-menopausal-versus-post-menopausal-women-by-transabdominal-ultrasound-a-feasibility-study
#5
Adrian Balica, Daniella Wald-Spielman, Katherine Schertz, Susan Egan, Gloria Bachmann
OBJECTIVE: As life expectancy increases, the number of women reporting adverse genito-urinary symptoms (genitourinary syndrome of menopause; GSM) from menopause, including vaginal dryness and sexual pain, also will increase. Current objective measurements of vaginal atrophy such as maturation index require vaginal swabs and are invasive; at present, no minimally invasive measurements exist. The purpose of this study was to assess whether total vaginal wall thickness (TVT) and total vaginal mucosa thickness (TMT) as measured by transabdominal ultrasound could qualify as additional objective markers of vaginal wall thinning which could be related to menopausal status...
August 2017: Maturitas
https://www.readbyqxmd.com/read/28595251/use-of-turn-in-skin-flaps-for-nasal-lining-reconstruction
#6
Memet Yazar, Sevgi Kurt Yazar, Erol Kozanoğlu, Murat Diyarbakırlıoğlu, Hikmet İhsan Eren
BACKGROUND: Reconstruction of the nasal lining is the most difficult part of complex nasal reconstruction because the mucosa has a unique texture and fineness. Many techniques, ranging from skin grafts to local flaps, have been applied for the reconstruction of the mucosa. In some cases, even free flaps have been used. OBJECTIVE: The aim of this study was to discuss the feasibility of using turn-in flaps in nasal reconstruction. MATERIALS AND METHODS: Seventeen patients with full-thickness nasal defects underwent reconstruction with turn-in flaps...
June 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28593788/a-complication-following-a-biopsy-sample-in-eosinophilic-esophagitis
#7
Antonio Cerezo Ruiz, Encarnación Parras Mejías, José María Martos Becerra
We present a case of a young 16 year old patient that had an esophageal perforation in the context of eosinophilic esophagitis. The esophagus showed vertical lacerations and mucosal thickness on endoscopy, thus a biopsy was performed in the proximal section which resulted in profuse bleeding due to a deep mucosal tear. A subsequent computed tomography scan revealed a perforation. Due to the absence of symptoms the patient was managed conservatively. The patient was discharged within 48 hours after admission...
June 8, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28576521/the-effect-of-caffeic-acid-phenethyl-ester-cape-on-tympanosclerosis
#8
İbrahim Ağrı, Arzu Erdal Ağrı, Mehmet Eser Sancaktar, Asude Ünal, Erkan Can, Mustafa Bakırtaş, Fatih Yılmaz, Mehmet Derya Demirağ, Recep Ünal
OBJECTIVE: To investigate the effects of caffeic acid phenethyl ester (CAPE) on tympanosclerosis. MATERIALS AND METHODS: Thirty-two male Sprague Dawley rats were separated into 4 groups as CAPE (n = 10), alcohol (n = 10), control (n = 8) and normal (n = 4) groups. All tympanic membranes except normal group were myringotomised and type 3 Streptococcus pneumoniae strains was injected into their middle ears. Myringotomies were repeated for 5 weeks. Intraperitoneal (i...
April 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28545905/resveratrol-alleviates-oxidative-damage-in-enteric-neurons-and-associated-gastrointestinal-dysfunction-caused-by-chemotherapeutic-agent-oxaliplatin
#9
Elizabeth L Donald, Lily Stojanovska, Vasso Apostolopoulos, Kulmira Nurgali
Oxaliplatin is a first-line chemotherapeutic agent used for the treatment of colorectal cancer. Its use is associated with severe gastrointestinal (GI) side-effects, associated with oxidative damage and neurotoxicity to the enteric neurons. Resveratrol is a potent anti-oxidant that has been shown to protect against oxidative damage and neurotoxicity in other neurons and could therefore prevent oxaliplatin-induced damage to enteric neurons. We determined whether co-administration of resveratrol with oxaliplatin alleviates enteric neuron toxicity and GI dysfunction in mice...
May 17, 2017: Maturitas
https://www.readbyqxmd.com/read/28541554/activation-of-group-2-innate-lymphoid-cells-exacerbates-and-confers-corticosteroid-resistance-to-mouse-nasal-type-2-inflammation
#10
Taiyo Morikawa, Ayumi Fukuoka, Kazufumi Matsushita, Koubun Yasuda, Naruhito Iwasaki, Shoko Akasaki, Shigeharu Fujieda, Tomohiro Yoshimoto
Both Th2 cells and group 2 innate lymphoid cells (ILC2s) contribute to allergic diseases. However, their exact role and relationship in nasal allergic disorders is unclear. In this study, we investigated the cooperation of Th2 cells and ILC2s in a mouse model of nasal allergic disorder. To differentially activate Th2 cells and/or ILC2s in nasal mucosa, mice were intranasally administered ovalbumin (OVA) antigen, papain, an ILC2-activator, or both for 2 weeks. Epithelial thickness and number of eosinophils in the nasal mucosa were evaluated at 24 hours after the final challenge...
May 25, 2017: International Immunology
https://www.readbyqxmd.com/read/28523036/relationship-of-oral-tumor-thickness-with-the-rate-of-lymph-node-metastasis-in-neck-based-on-ct-scan
#11
Sohail Ahmed Khan, Sadaf Zia, Syeda Uzma Naqvi, Hatem Adel, Syed Omair Adil, Munawar Hussain
OBJECTIVE: To determine the relationship of tumor thickness of oral lesions with metastasis in neck based on CT scan. METHODS: A total of 58 oral squamous cell carcinoma patients having the median age of 46 (39-55) years. with either gender presented with malignant tumor of buccal mucosa and tongue were prospectively enrolled. A CT Scan with contrast was performed on all patients. Correlation of tumor thickness level with metastasis in neck was calculated using spearman's rank correlation coefficient test...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28512278/use-of-collagen-matrix-for-augmentation-of-the-peri-implant-soft-tissue-at-the-time-of-immediate-implant-placement
#12
Gregor-Georg Zafiropoulos, Gordon John
AIM: The aim of this study was to determine the treatment outcome of the use of a porcine monolayer collagen matrix (mCM) to augment peri-implant soft tissue in conjunction with immediate implant placement as an alternative to patient's own connective tissue. MATERIALS AND METHODS: A total of 27 implants were placed immediately in 27 patients (14 males and 13 females, with a mean age of 52.2 years) with simultaneous augmentation of the soft tissue by the use of a mCM...
May 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28507862/eyelid-reconstruction-using-oral-mucosa-and-ear-cartilage-strips-as-sandwich-grafting
#13
Naoto Yamamoto, Hiroyuki Ogi, Satoshi Yanagibayashi, Ryuichi Yoshida, Megumi Takikawa, Akio Nishijima, Tomoharu Kiyosawa
BACKGROUND: The eyelid structure can be divided into an inner layer and an outer layer. Reconstruction of a full-thickness eyelid defect is accomplished by full-thickness composite tissue transfer or combined layered reconstruction. We present a new technique for inner layer reconstruction using ear cartilage and oral mucosa. METHODS: The oral mucosa graft is harvested from the inner side of the lower lip to fit the defect size and shape. The ear cartilage graft is harvested as a rectangular strip...
April 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28492157/angiomyxolipoma-of-tongue
#14
Manas Bajpai, Betina Chandolia, Manika Arora
Angiomyxolipoma is a rare histological variant of lipoma, characterized by proliferation of adipose tissue associated with a variable amount of myxoid stroma with numerous thick- and thin-walled blood vessels. An exhaustive literature review could reveal only 12 cases of angiomyxolipoma affecting subcutaneous tissue, subungual area and spermatic cord. In oral cavity, only 2 cases of angiomyxolipoma have been reported to date, one case in the buccal mucosa and one case in the floor of the mouth. Hence, this is only the third case of angiomyxolipoma affecting oral cavity and the first case of angiomyxolipoma of the tongue...
April 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28489125/severe-hypoproteinemia-as-a-harbinger-of-m%C3%A3-n%C3%A3-trier-s-disease-in-autoimmune-pancreatitis
#15
Julio Maria Fonseca Chebli, Liliana Andrade Chebli, Tarsila Campanha da Rocha Ribeiro, Pedro Duarte Gaburri
Ménétrier's disease is an extremely rare disease of unknown etiology causing gastric mucosal hypertrophy and protein-losing gastropathy. Rare cases of this condition have been reported in patients with autoimmune diseases. However, to the best of our knowledge, Ménétrier's disease associated with autoimmune pancreatitis (AIP) has never been reported. We described a case of severe hypoproteinemia as a harbinger of Ménétrier's disease associated with AIP. The patient was successfully treated with octreotide and high-protein diet, which led to symptomatic remission and significant improvement in serum levels of albumin and recovery of the nutritional status...
March 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28479684/redefining-epithelial-characterization-in-oral-submucous-fibrosis-using-morphometric-analysis
#16
Ajit Singh Rathore, Amit Gupta, Devi Charan Shetty, Kiran Kumar, Raghu Dhanapal
BACKGROUND: Oral submucous fibrosis (OSMF) is a chronic oral mucosal disease characterized by progressive deposition of collagen in subepithelial connective tissue and epithelial atrophy. The present study was conducted to evaluate the changes in epithelial thickness and cellular and nuclear morphometric characteristics of parabasal and spinous compartments of the epithelium in various stages of OSMF in comparison to normal epithelium. MATERIALS AND METHODS: Sample included 30 cases of OSMF of various stages and five cases of normal buccal mucosa...
January 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28475086/timing-of-soft-tissue-management-around-dental-implants-a-suggested-protocol
#17
Mahdi Kadkhodazadeh, Reza Amid, Mehdi Ekhlasmand Kermani, Mahdieh Mirakhori, Sepanta Hosseinpour
Survival of dental implants depends on several factors; soft tissue (ST) management around dental implants is one of the foremost. Several studies have suggested techniques for ST management around dental implants, but none of them has discussed a suitable timetable for this process. This study aimed to review published articles related to the timing of ST management around dental implants and suggest a customized treatment protocol. A search of the PubMed database was conducted; the search was limited to English-language articles published from January 1995 to July 2015 with available full texts...
May 2017: General Dentistry
https://www.readbyqxmd.com/read/28473890/evaluation-of-the-morphological-features-of-the-uterine-tubes-during-postnatal-development-in-west-african-dwarf-goats-capra-hircus
#18
Clifford Nwabugwu Abiaezute, Innocent Chima Nwaogu, Udensi Maduabuchi Igwebuike
The objective of this study was to highlight the postnatal development of the uterine tubes of the West African Dwarf goat from birth to 28 weeks of age by gross examination and light microscopy. There was a caudal migration of the paired uterine tubes from behind the paired kidneys at birth to the pelvic inlet at week 8 of age. Each uterine tube exhibited three segments namely; infundibulum, ampulla and isthmus. A marked flexure, the utero-tubal junction, was the point at which the uterine tubes joined the uterine horns...
2017: Veterinary Research Forum
https://www.readbyqxmd.com/read/28467284/clinical-topographical-anatomy-of-the-gastro-oesophageal-junction-in-the-cat
#19
Agni Voutsinou, Lysimachos G Papazoglou, Ioannis Antonopoulos, Timoleon S Rallis
Objectives The purpose of the present study was to describe histologically the gastro-oesophageal junction in the cat and interrelationships of this region. Our hypothesis was that cats are devoid of abdominal oesophagus. Methods Three centimetres of the terminal oesophagus, the phreno-oesophageal membrane with 1-2 cm margins of the diaphragmatic crural muscle and the proximal 3 cm of the gastric cardia were obtained from nine domestic shorthair cats and one domestic longhair cat that were euthanased for reasons other than digestive tract pathology...
May 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28452723/-ultrasound-diagnosis-of-forms-iatrogenic-maxillary-sinusitis
#20
S Varzhapetyan
Purpose of the study was to evaluate the effectiveness of diagnosis of the mixed form of iatrogenic maxillary sinusitis. Was studied 21 (100%) patients with a fragment of a remote tooth in the sinus - 12 (57,1%), with a filling material - 9 (42,9%) in the maxillary sinus with an ultrasound diagnostic device ACUSON X 500, ATSmod.539 (SIEMENS) in B-mode using a linear sensor with a working surface length of 37 mm, with a frequency mode of 7.5-10 MHz. The evaluation of pathological changes in the sinuses and their interpretation were carried out according to the criteria given in the literature...
February 2017: Georgian Medical News
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