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Mucosal thickness

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https://www.readbyqxmd.com/read/27911098/siga-deficiency-in-individual-small-airways-is-associated-with-persistent-inflammation-and-remodeling
#1
Vasiliy V Polosukhin, Bradley W Richmond, Rui-Hong Du, Justin M Cates, Pingsheng Wu, Hui Nian, Pierre P Massion, Lorraine B Ware, Jae Woo Lee, Alexey V Kononov, William E Lawson, Timothy S Blackwell
RATIONALE: Maintenance of a surface immune barrier is important for homeostasis in organs with mucosal surfaces that interface with the external environment; however, the role of the mucosal immune system in chronic lung diseases is incompletely understood. OBJECTIVES: We examined the relationship between secretory immunoglobulin A (SIgA) on the mucosal surface of small airways and parameters of inflammation and airway wall remodeling in chronic obstructive pulmonary disease (COPD)...
December 2, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27899200/-mucoadhesive-buccal-films-of-tramadol-for-effective-pain-management
#2
Xiao-Qin Li, Zhao-Ming Ye, Jian-Bing Wang, Cai-Rong Fan, Ai-Wu Pan, Cong Li, Ren-Bing Zhang
BACKGROUND AND OBJECTIVES: Tramadol hydrochloride is a centrally-acting synthetic opioid analgesic binding to specific opioid receptors. It is used in the management of chronic pain and is recommended as first line drug in the treatment of postoperative or orthopedic injury induced acute pain. The present work is designed to prepare and evaluate mucoadhesive buccal film of tramadol hydrochloride as a novel form of prolonged analgesia for patients with orthopedic injuries. METHODS: Buccal films of tramadol hydrochloride were prepared by solvent casting method...
November 26, 2016: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/27898453/resolution-of-rectal-prolapse-by-vaginal-reconstruction
#3
Hemikaa Devakumar, Neeraja Chandrasekaran, Alexandriah Alas, Laura Martin, G Willy Davila, Eric Hurtado
BACKGROUND: Rectal prolapse is a disorder of the pelvic floor in which the layers of the rectal mucosa protrude outward through the anus. Surgical repair is the mainstay of treatment. Options include intra-abdominal procedures such as rectopexy and perineal procedures such as the Delorme and Altemeier perineal rectosigmoidectomy. Rectal and vaginal prolapse can often coexist. However, to our knowledge, there are no reported cases of rectal prolapse resolved by the repair of a compressive enterocele abutting the anterior rectal wall through a vaginal approach alone...
November 28, 2016: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/27885604/assays-to-study-the-interaction-of-campylobacter-jejuni-with-the-mucosal-surface
#4
Marguerite Clyne, Gina Duggan, Ciara Dunne, Brendan Dolan, Luis Alverez, Billy Bourke
Mucosal colonization and overcoming the mucosal barrier are essential steps in the establishment of infection by Campylobacter jejuni. The interaction between C. jejuni and host cells, including binding and invasion, is thought to be the key virulence factor important for pathogenesis of C. jejuni infections in animals or humans. The intestinal mucosal barrier is composed of a polarized epithelium covered by a thick adherent mucus gel layer. There is a requirement for cell culture assays of infection to accurately represent the in vivo mucosal surface...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27867747/early-diagnosis-of-genital-mucosal-melanoma-how-good-are-our-dermoscopic-criteria
#5
Tova Rogers, Melissa Pulitzer, Maria L Marino, Ashfaq A Marghoob, Oliver Zivanovic, Michael A Marchetti
BACKGROUND: There are limited studies on the dermoscopic features of mucosal melanoma, particularly early-stage lesions. Described criteria include the presence of blue, gray, or white colors, with a reported sensitivity of 100%. It is unclear if these features will aid in the detection of early mucosal melanoma or improve diagnostic accuracy compared to naked-eye examination alone. CASE: An Asian female in her fifties was referred for evaluation of an asymptomatic, irregularly pigmented patch of the clitoral hood and labia minora of unknown duration...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27867742/dermoscopic-appearance-of-an-amelanotic-mucosal-melanoma
#6
Andreas Blum, Ulrike Beck-Zoul, Laura Held, Sylvie Haase
BACKGROUND: Hypomelanotic or amelanotic melanomas are challenging to identify, especially at mucosal sites. The dermoscopic clues to the diagnosis of mucosal melanomas have been reported to be structureless zones with the presence of blue, gray, or white colors. CASE: A female in her seventies noted a new lesion on the inside of her right labia that first appeared two months prior. Her past medical history was significant for rheumatoid arthritis requiring ongoing treatment with methotrexate for 20 years and adalimumab for 10 years...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27863547/identification-of-histamine-receptors-in-the-canine-gastrointestinal-tract
#7
Alyssa Sullivant, Andrew Mackin, Todd Pharr, Jim Cooley, Robert Wills, Todd Archer
The important role of histamine in chronic gastrointestinal diseases has been increasingly recognized over the last two decades in human medicine. Histamine is released following mast cell activation and exerts its action through binding to four different histamine receptors (H1, H2, H3, and H4). Histamine receptors are dispersed throughout the body, and each different receptor mediates a unique response. Documentation of the presence and type of histamine receptors in the differing sections of the canine gastrointestinal tract will provide additional research opportunities to further explore the role of histamine and its receptors in chronic canine enteropathies, as well as potential therapeutic options...
December 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27832330/the-evaluation-of-rectal-mucosal-punch-biopsy-in-the-diagnosis-of-hirschsprung-s-disease-a-30-year-experience-of-954-patients
#8
Koichiro Yoshimaru, Yoshiaki Kinoshita, Yusuke Yanagi, Satoshi Obata, Takahiro Jimbo, Tsuyoshi Iwanaka, Yoshiaki Takahashi, Genshiro Esumi, Junko A Miyata, Toshiharu Matsuura, Tomoko Izaki, Tomoaki Taguchi
PURPOSE: For 30 years, we have consecutively performed rectal mucosal punch biopsy to diagnose Hirschsprung's disease. The aim of this study was to evaluate the safety of our technique. METHODS: Patients with suspected Hirschsprung's disease who underwent punch biopsy, including our original "K-PUNCH" method using an S-moid forceps and non-specific blood-collecting tube at our department and branch hospital between April 1986 and March 2016 were included in the present study...
November 10, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27830882/histological-changes-in-the-vulva-and-vagina-from-ovariectomised-rats-undergoing-oestrogen-treatment
#9
Radu Florin Mocan-Hognogi, Nicolae Costin, Andrei Malutan, Razvan Ciortea, Ioana Alexandra Trif, Andras Laszlo Nagy, Marian Liviu Bogdan, Dan Mihu
BACKGROUND: The purpose of this study was to assess the histological changes occurring in the vagina and vulva in ovariectomised female rats, as well as the response to the administration of injectable oestrogens. MATERIAL AND METHODS: We used 30 female Wistar white rats, distributed as follows: group 1 - the control group, group 2 - the operated but untreated rats, and groups 3, 4 and 5, operated rats, to which oestrogenic treatment was administered (Estradiol, Estradurin, Sintofolin), at a dosage of 0...
November 10, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27822571/histology-and-surface-ultrastructure-during-early-healing-after-gingival-augmentation-with-a-three-dimensional-collagen-matrix-a-report-of-six-cases
#10
Darian Rusu, Stefan-Ioan Stratul, Dana Festila, Petra Surlin, Adrian Kasaj, Flavia Baderca, Marius Boariu, Holger Jentsch, Cosmin Locovei, Bogdan Calenic
OBJECTIVES: The objective of the present case series is to describe the histology and surface ultrastructure of augmented keratinized gingival mucosa in humans during the early healing phase after surgical placement of a xenogeneic collagen matrix. METHOD AND MATERIALS: Six patients underwent surgical augmentation of keratinized tissue by placement of a three-dimensional (3D) xenogeneic collagen matrix. Full-depth mucosal biopsies including original attached gingiva, augmented gingiva, and the separation zone were performed at baseline and at postoperative days 7 and 14...
November 7, 2016: Quintessence International
https://www.readbyqxmd.com/read/27805722/treatment-of-chemically-induced-oral-ulcer-using-adipose-derived-mesenchymal-stem-cell-sheet
#11
Doh Young Lee, Hee-Bok Kim, In Kyoung Shim, Nobuo Kanai, Teruo Okano, Seong Keun Kwon
BACKGROUND: This study investigated the effects of mesenchymal stem cell (MSC) sheet transplantation on healing of chemically induced oral ulceration in a rabbit animal model. METHODS: Oral mucosal ulcers were induced by topical application of filter paper soaked with 70% acetic acid to the anterior gingiva and buccal mucosa of 12 New Zealand white rabbits. The animals were randomly assigned to two groups: with (treatment group, n = 6) or without (control group, n = 6) cell sheets applied to ulcers...
November 2, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27805441/comparison-of-contrast-media-for-visualization-of-the-colon-of-healthy-dogs-during-computed-tomography-and-ultrasonography
#12
Byunggyu Cheon, Sohyeon Moon, Seungjo Park, Sang-Kwon Lee, Sunghwa Hong, Hyun Cho, Jihye Choi
OBJECTIVE To evaluate contrast agents for their ability to improve visualization of the colon wall and lumen during CT and ultrasonography. ANIMALS 10 healthy adult Beagles. PROCEDURES Food was withheld from dogs for 36 hours, after which dogs consumed 250 mL of polyethylene glycol solution. Dogs were then anesthetized, a contrast agent (tap water, diluted barium, or air; order randomly assigned) was administered rectally, iodine contrast medium (880 mg of I/kg) was administered IV, and CT and ultrasonography of the colon were performed...
November 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27803929/advances-in-understanding-how-heavy-metal-pollution-triggers-gastric-cancer
#13
REVIEW
Wenzhen Yuan, Ning Yang, Xiangkai Li
With the development of industrialization and urbanization, heavy metals contamination has become a major environmental problem. Numerous investigations have revealed an association between heavy metal exposure and the incidence and mortality of gastric cancer. The mechanisms of heavy metals (lead, cadmium, mercury, chromium, and arsenic) contamination leading to gastric cancer are concluded in this review. There are four main potential mechanisms: (1) Heavy metals disrupt the gastric mucosal barrier by decreasing mucosal thickness, mucus content, and basal acid output, thereby affecting the function of E-cadherin and inducing reactive oxygen species (ROS) damage...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27796556/nasal-septum-configuration-as-a-basis-for-novel-septal-splints
#14
Nina Furbish, Thomas S Kühnel
The objective is to use anatomical determinations of nasal septum shape and surface area in adults as a design basis for silastic septal splints of universal size and fit and offering maximum possible surface coverage. The objective is also to devise a method of securing the septal splints, so that surface pressure on septal mucosa is distributed as evenly as possible while not interfering with capillary perfusion. Nasal septum area was determined in 21 Caucasian body donors, and nasal septum thickness was measured in 20 CT scans...
October 31, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27790839/low-residue-diet-fed-to-rabbits-induces-histomorphological-and-biomechanical-remodeling-of-small-intestine
#15
Y Liu, J Zhao, D Liao, L Bao, H Gregersen
BACKGROUND: The composition of ingested food is important for the gut microbiome and intestinal homeostasis. We have previously demonstrated that the structure and mechanical properties in the small intestine remodel significantly during fasting. However, it is not clear to what extent the intestinal mechanical properties changes when the composition of food is changed. This study aimed to investigate the passive biomechanical properties and intestinal tissue remodeling in rabbits fed a low-residue diet...
October 27, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27788054/diphtheritic-stomatitis-in-yellow-eyed-penguins-megadyptes-antipodes-in-new-zealand
#16
Maurice R Alley, Rod B Suepaul, Bruce McKinlay, Melanie J Young, Jianning Wang, Kerri J Morgan, Stuart A Hunter, Brett D Gartrell
Diphtheritic stomatitis is a seasonal disease that has been recognized as a syndrome in Yellow-eyed Penguin ( Megadyptes antipodes ) chicks in New Zealand for >10 yr. It was present in about 50% of 234 chicks examined since 2002 and is characterized by a thick serocellular exudate in the oral cavity of 1-4-wk-old chicks. The syndrome includes inanition, weight loss, and death in many affected birds. Microscopically, the lesions varied in severity. Most affected chicks had severe, locally extensive, ulcerative stomatitis with large amounts of exudate containing numerous bacteria; a smaller number had mild focal lesions with smaller amounts of exudate and bacteria...
October 27, 2016: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/27779610/factors-influencing-the-soft-tissue-changes-around-single-laser-microtextured-implants-abutments-in-the-anterior-maxilla-a-5-year-retrospective-study
#17
Renzo Guarnieri, Luca Savio, Alessandro Bermonds des Ambrois, Stefano Ippoliti, Francesco Zuffetti, Luigi Vito Stefanelli, Stefano Di Carlo, Giorgio Pompa
PURPOSE: The aim of this study was to evaluate the possible factors that influenced the periimplant soft tissue changes around single implants-abutments with laser-microtextured surface (LMS) in the esthetic zone. MATERIALS AND METHODS: Thirty-nine units, formed by implant-abutment with LMS were studied. Variables possibly associated with the periimplant soft tissue changes were obtained from clinical measurements (plaque [present/absent], periimplant biotype [thin/thick], and probing depth); intrasurgical measurements (vertical height in millimeters of the keratinized gingiva in the vestibular part of the implant site vestibular keratinized gingiva [VKG], implant vestibular crestal exposition, vestibular crestal level, and vestibular bone width); cast models (implant position [buccal/palatal], implant abutments angle); periapical radiographs (distance from the contact point to the interproximal bone crest of the adjacent tooth [CP-BC], distance from the contact point to the implant platform [CP-P], distance from the contact point to the first bone to implant contact [CP-IB]); and digital clinical photographs...
December 2016: Implant Dentistry
https://www.readbyqxmd.com/read/27756631/presence-of-dna-extracellular-traps-but-not-muc5ac-and-muc5b-mucin-in-mucoid-plugs-casts-of-infectious-laryngotracheitis-virus-iltv-infected-tracheas-of-chickens
#18
Vishwanatha R A P Reddy, Ivan Trus, Hans J Nauwynck
Although it has been speculated that the tracheal obstructions and asphyxiation during acute infectious laryngotracheitis (ILT) are due to mucoid plugs/casts formed by mucus hypersecretion, there are no reports demonstrating this. Hence, in the present study, we first examined if the main respiratory mucins, MUC5AC and MUC5B, are expressed in the mucosae of larynx, trachea and bronchi of mock-inoculated and ILTV infected chickens. Second, the tracheas with plugs/casts were stained for mucins (MUC5AC and MUC5B) and nuclear material (traps)...
January 2, 2017: Virus Research
https://www.readbyqxmd.com/read/27751517/combined-effect-of-bone-marrow-derived-mesenchymal-stem-cells-and-nitric-oxide-inducer-on-injured-gastric-mucosa-in-a-rat-model
#19
Laila Rashed, Doaa Mostafa Gharib, Rania Elsayed Hussein, Ola Tork, Azza Abusree
AIM: To study the effect of intravenous injection of bone marrow mesenchymal stem cells (BMMSCs), alone and combined with NO inducer in gastric ulcer healing in a rat model. METHODS: Rats were divided into controls, gastric ulcer, gastric ulcer receiving mesenchymal stem cells (MSCs), gastric ulcer receiving NO inducer (l-Arginine), gastric ulcer receiving MSCs plus NO inducer (l-Arginine) groups. MSCs were given in a dose of (10(6)cells) by intravenous injection...
September 28, 2016: Tissue & Cell
https://www.readbyqxmd.com/read/27747637/peri-implant-mucosal-dehiscence-coverage-with-a-modified-semilunar-coronary-positioned-flap-in-posterior-maxilla-a-case-report
#20
Daisuke Ueno, Jayanetti Asiri Jayawardena, Takashi Kurokawa
Soft tissue dehiscence around dental implant has frequently been observed and it may lead to poor oral hygiene, especially around crowns that exhibit contours with prominent convexity. The present case demonstrates a peri-implant mucosal dehiscence coverage with modified semilunar coronary positioned flap (CPF) in #15 and 16. A semilunar partial-thickness incision was performed 7-10 mm apical from the facial gingival margin. Then, intrasulcular partial-thickness incision was tunneled to the semilunar incision...
December 2015: Int J Implant Dent
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