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Mucosal thickness

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https://www.readbyqxmd.com/read/28079827/differentiating-malignant-from-benign-gastric-mucosal-lesions-with-quantitative-analysis-in-dual-energy-spectral-computed-tomography-initial-experience
#1
Xiaoyan Meng, Cheng Ni, Yaqi Shen, Xuemei Hu, Xiao Chen, Zhen Li, Daoyu Hu
To investigate the value of quantitative analysis in dual energy spectral computed tomography (DESCT) for differentiating malignant gastric mucosal lesions from benign gastric mucosal lesions (including gastric inflammation [GI] and normal gastric mucosa [NGM]). This study was approved by the ethics committee, and all patients provided written informed consent. A total of 161 consecutive patients (63 with gastric cancer [GC], 48 with GI, and 50 with NGM) who underwent dual-phase contrast enhanced DESCT scans in the arterial phase (AP) and portal venous phase (PVP) were included in this study...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28075196/typhlitis-neutropenic-enterocolitis-in-patients-with-acute-leukemia-a-review
#2
Rodrigo Portugal, Marcio Nucci
Typhlitis is an abdominal complication of cancer chemotherapy, affecting mostly patients receiving intensive chemotherapeutic regimens with high potential to induce mucosal damage, such as patients with acute leukemia. Despite being relatively frequent, there are no randomized trials or high-quality cohort studies addressing important aspects of the diagnosis and management of the disease. Areas covered: In this review we discuss the gaps in the literature, acknowledging that the evidences for recommendations regarding the management of typhlitis are mostly expert opinion...
January 11, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/28058023/laparoscopic-and-endoscopic-co-operative-surgery-for-non-ampullary-duodenal-tumors
#3
Daisuke Ichikawa, Shuhei Komatsu, Osamu Dohi, Yuji Naito, Toshiyuki Kosuga, Kazuhiro Kamada, Kazuma Okamoto, Yoshito Itoh, Eigo Otsuji
AIM: To assess the safety and feasibility of laparoscopic and endoscopic co-operative surgery (LECS) for early non-ampullary duodenal tumors. METHODS: Twelve patients with a non-ampullary duodenal tumor underwent LECS at our hospital. One patient had two mucosal lesions in the duodenum. The indication for this procedure was the presence of duodenal tumors with a low risk for lymph node metastasis. In particular, the tumors included small (less than 10 mm) submucosal tumors (SMT) and epithelial mucosal tumors, such as mucosal cancers or large mucosal adenomas with malignant suspicion...
December 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28054754/the-stce-metalloprotease-of-enterohaemorrhagic-escherichia-coli-reduces-the-inner-mucus-layer-and-promotes-adherence-to-human-colonic-epithelium-ex-vivo
#4
Claire L Hews, Seav-Ly Tran, Udo Wegmann, Bernard Brett, Alistair D S Walsham, Devon Kavanaugh, Nicole J Ward, Nathalie Juge, Stephanie Schüller
Enterohaemorrhagic E. coli (EHEC) is a major foodborne pathogen and tightly adheres to human colonic epithelium by forming attaching/effacing lesions. To reach the epithelial surface, EHEC must penetrate the thick mucus layer protecting the colonic epithelium. In this study, we investigated how EHEC interacts with the intestinal mucus layer using mucin-producing LS174T colon carcinoma cells and human colonic mucosal biopsies. The level of EHEC binding and A/E lesion formation in LS174T cells was higher compared to mucin-deficient colon carcinoma cell lines, and initial adherence was independent of the presence of flagellin, E...
January 5, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28052695/management-of-early-colonic-neoplasia-where-are-we-now-and-where-are-we-heading
#5
Gaius Longcroft-Wheaton, Pradeep Bhandari
There have been considerable advances in the endoscopic treatment of colorectal neoplasia. The development of endoscopic submucosal dissection and full thickness resection techniques is changing the way benign disease and early cancers are managed. This article reviews the evidence behind these new techniques and discusses where this field is likely to move in the future. Areas covered: A PubMed literature review of resection techniques for colonic neoplasia was performed. The clinical and cost effectiveness of endoscopic mucosal resection (EMR) is examined...
January 4, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28050414/radiological-study-of-maxillary-sinus-using-cbct-relationship-between-mucosal-thickening-and-common-anatomic-variants-in-chronic-rhinosinusitis
#6
Marco Capelli, Patrizia Gatti
INTRODUCTION: Inflammatory diseases of the maxillary sinus favour the thickening of the sinus mucosa. Therefore, it might be possible to establish a radiological, pathological threshold of mucosal thickening. Furthermore, there is an association between common anatomic variants of the nose and maxillary mucosal thickening. AIM: To define the pathological thickening of maxillary sinus mucosa and its association with the presence of common anatomic variants (concha bullosa, Haller's cell and accessory maxillary ostium)...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28048594/su-f-t-360-dosimetric-impacts-on-the-mucosa-and-bone-in-radiotherapy-with-unflattened-photon-beams
#7
J Chow, A Owrangi
PURPOSE: This study investigated the dosimetric impacts on the mucosa and bone when using the unflattened photon beams in radiotherapy. Dose calculations were carried out by Monte Carlo simulation. METHODS: Heterogeneous phantoms containing water (soft tissue and mucosa), air and bone, with mucosa thicknesses varying from 0.5 - 3 mm were irradiated by the 6 MV unflattened and flattened photon beams (field size = 10 × 10 cm(2) ), produced by a Varian TrueBEAM linear accelerator...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046394/su-c-brc-05-monte-carlo-calculations-to-establish-a-simple-relation-of-backscatter-dose-enhancement-around-high-z-dental-alloy-to-its-atomic-number
#8
S Utsunomiya, N Kushima, K Katsura, S Tanabe, T Hayakawa, H Sakai, T Yamada, H Takahashi, E Abe, S Wada, H Aoyama
PURPOSE: To establish a simple relation of backscatter dose enhancement around a high-Z dental alloy in head and neck radiation therapy to its average atomic number based on Monte Carlo calculations. METHODS: The PHITS Monte Carlo code was used to calculate dose enhancement, which is quantified by the backscatter dose factor (BSDF). The accuracy of the beam modeling with PHITS was verified by comparing with basic measured data namely PDDs and dose profiles. In the simulation, a high-Z alloy of 1 cm cube was embedded into a tough water phantom irradiated by a 6-MV (nominal) X-ray beam of 10 cm × 10 cm field size of Novalis TX (Brainlab)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28024718/patterns-of-dysphagia-and-acute-toxicities-in-patients-with-head-and-neck-cancer-undergoing-helical-imrt%C3%A2-concurrent-chemotherapy
#9
Laura B Moroney, Jennifer Helios, Elizabeth C Ward, Jane Crombie, Leesa F Wockner, Clare L Burns, Ann-Louise Spurgin, Claire Blake, Lizbeth Kenny, Brett G M Hughes
BACKGROUND: There is limited prospective data reporting the extent of treatment related toxicities associated with helical Intensity Modulated Radiotherapy (H-IMRT) for head and neck cancer (HNC). The study aim was to investigate severity, peak incidence and recovery patterns of dysphagia and related toxicities in patients undergoing H-IMRT±chemotherapy to examine when patients are experiencing symptoms requiring supportive clinical care. METHODS: Prospective study of 212 patients undergoing H-IMRT...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/27988851/outcomes-following-sclerotherapy-for-mucosal-rectal-prolapse-with-oily-phenol-injection-single-centre-review
#10
Rohini Sahay, Govind Murthi, Richard Lindley
AIM OF THE STUDY: To review the outcomes of injection sclerotherapy with oily phenol for mucosal rectal prolapse. METHODS: Retrospective case note review of all children who underwent sclerotherapy with oily phenol injection as primary surgical intervention for mucosal rectal prolapse, from January 2007 to December 2015. MAIN RESULTS: A total of 31 patients were identified. Mean age at presentation was 4.8 years (range 5 months-12 years)...
December 17, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27966266/full-thickness-esophageal-regeneration-in-pig-using-a-polyurethane-mucosal-cell-seeded-graft
#11
Matthew R Barron, Ellen W Blanco, Johnathon M Aho, Jason Chakroff, Jed Johnson, Steve D Cassivi, William A Carey, Dennis A Wigle
Malignant esophageal pathology typically requires resection of a portion of esophagus. The aim of this study was to investigate attachment and growth of swine esophageal mucosal cells on electrospun synthetic nanofiber matrices of varying chemistries and to determine whether a mucosal-seeded graft, in a swine animal model, could induce regeneration. We isolated swine mucosal esophageal cells and seeded them onto five different matrix materials. Matrix samples were cultured for up to 14 days, after which matrices were analyzed for cell attachment...
December 14, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27939352/age-and-region-related-changes-in-the-biomechanical-properties-and-composition-of-the-human-ureter
#12
Dimitrios P Sokolis, Despoina C Petsepe, Stavroula A Papadodima, Stavros K Kourkoulis
The ureter has been largely overlooked heretofore in the study of the biomechanics of soft biological tissues, although there has been significant motivation to use its biomechanical properties as inputs to mathematical models of ureteral function. Herein, we used histological analysis for quantification of collagen contents and thickness/area of ureteral layers, with concomitant geometrical analysis of zero-stress and no-load states, and inflation/extension testing to biomechanically characterize with the Fung-type model the ureters from cadavers...
January 25, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/27911098/siga-deficiency-in-individual-small-airways-is-associated-with-persistent-inflammation-and-remodeling
#13
Vasiliy V Polosukhin, Bradley W Richmond, Rui-Hong Du, Justin M Cates, Pingsheng Wu, Hui Nian, Pierre P Massion, Lorraine B Ware, Jae Woo Lee, Alexey V Kononov, William E Lawson, Timothy S Blackwell
RATIONALE: Maintenance of a surface immune barrier is important for homeostasis in organs with mucosal surfaces that interface with the external environment; however, the role of the mucosal immune system in chronic lung diseases is incompletely understood. OBJECTIVES: We examined the relationship between secretory immunoglobulin A (SIgA) on the mucosal surface of small airways and parameters of inflammation and airway wall remodeling in chronic obstructive pulmonary disease (COPD)...
December 2, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27899200/-mucoadhesive-buccal-films-of-tramadol-for-effective-pain-management
#14
Xiao-Qin Li, Zhao-Ming Ye, Jian-Bing Wang, Cai-Rong Fan, Ai-Wu Pan, Cong Li, Ren-Bing Zhang
BACKGROUND AND OBJECTIVES: Tramadol hydrochloride is a centrally-acting synthetic opioid analgesic binding to specific opioid receptors. It is used in the management of chronic pain and is recommended as first line drug in the treatment of postoperative or orthopedic injury induced acute pain. The present work is designed to prepare and evaluate mucoadhesive buccal film of tramadol hydrochloride as a novel form of prolonged analgesia for patients with orthopedic injuries. METHODS: Buccal films of tramadol hydrochloride were prepared by solvent casting method...
November 26, 2016: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/27898453/resolution-of-rectal-prolapse-by-vaginal-reconstruction
#15
Hemikaa Devakumar, Neeraja Chandrasekaran, Alexandriah Alas, Laura Martin, G Willy Davila, Eric Hurtado
BACKGROUND: Rectal prolapse is a disorder of the pelvic floor in which the layers of the rectal mucosa protrude outward through the anus. Surgical repair is the mainstay of treatment. Options include intra-abdominal procedures such as rectopexy and perineal procedures such as the Delorme and Altemeier perineal rectosigmoidectomy. Rectal and vaginal prolapse can often coexist. However, to our knowledge, there are no reported cases of rectal prolapse resolved by the repair of a compressive enterocele abutting the anterior rectal wall through a vaginal approach alone...
January 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/27885604/assays-to-study-the-interaction-of-campylobacter-jejuni-with-the-mucosal-surface
#16
Marguerite Clyne, Gina Duggan, Ciara Dunne, Brendan Dolan, Luis Alverez, Billy Bourke
Mucosal colonization and overcoming the mucosal barrier are essential steps in the establishment of infection by Campylobacter jejuni. The interaction between C. jejuni and host cells, including binding and invasion, is thought to be the key virulence factor important for pathogenesis of C. jejuni infections in animals or humans. The intestinal mucosal barrier is composed of a polarized epithelium covered by a thick adherent mucus gel layer. There is a requirement for cell culture assays of infection to accurately represent the in vivo mucosal surface...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27867747/early-diagnosis-of-genital-mucosal-melanoma-how-good-are-our-dermoscopic-criteria
#17
Tova Rogers, Melissa Pulitzer, Maria L Marino, Ashfaq A Marghoob, Oliver Zivanovic, Michael A Marchetti
BACKGROUND: There are limited studies on the dermoscopic features of mucosal melanoma, particularly early-stage lesions. Described criteria include the presence of blue, gray, or white colors, with a reported sensitivity of 100%. It is unclear if these features will aid in the detection of early mucosal melanoma or improve diagnostic accuracy compared to naked-eye examination alone. CASE: An Asian female in her fifties was referred for evaluation of an asymptomatic, irregularly pigmented patch of the clitoral hood and labia minora of unknown duration...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27867742/dermoscopic-appearance-of-an-amelanotic-mucosal-melanoma
#18
Andreas Blum, Ulrike Beck-Zoul, Laura Held, Sylvie Haase
BACKGROUND: Hypomelanotic or amelanotic melanomas are challenging to identify, especially at mucosal sites. The dermoscopic clues to the diagnosis of mucosal melanomas have been reported to be structureless zones with the presence of blue, gray, or white colors. CASE: A female in her seventies noted a new lesion on the inside of her right labia that first appeared two months prior. Her past medical history was significant for rheumatoid arthritis requiring ongoing treatment with methotrexate for 20 years and adalimumab for 10 years...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27863547/identification-of-histamine-receptors-in-the-canine-gastrointestinal-tract
#19
Alyssa Sullivant, Andrew Mackin, Todd Pharr, Jim Cooley, Robert Wills, Todd Archer
The important role of histamine in chronic gastrointestinal diseases has been increasingly recognized over the last two decades in human medicine. Histamine is released following mast cell activation and exerts its action through binding to four different histamine receptors (H1, H2, H3, and H4). Histamine receptors are dispersed throughout the body, and each different receptor mediates a unique response. Documentation of the presence and type of histamine receptors in the differing sections of the canine gastrointestinal tract will provide additional research opportunities to further explore the role of histamine and its receptors in chronic canine enteropathies, as well as potential therapeutic options...
December 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27832330/the-evaluation-of-rectal-mucosal-punch-biopsy-in-the-diagnosis-of-hirschsprung-s-disease-a-30-year-experience-of-954-patients
#20
Koichiro Yoshimaru, Yoshiaki Kinoshita, Yusuke Yanagi, Satoshi Obata, Takahiro Jimbo, Tsuyoshi Iwanaka, Yoshiaki Takahashi, Genshiro Esumi, Junko A Miyata, Toshiharu Matsuura, Tomoko Izaki, Tomoaki Taguchi
PURPOSE: For 30 years, we have consecutively performed rectal mucosal punch biopsy to diagnose Hirschsprung's disease. The aim of this study was to evaluate the safety of our technique. METHODS: Patients with suspected Hirschsprung's disease who underwent punch biopsy, including our original "K-PUNCH" method using an S-moid forceps and non-specific blood-collecting tube at our department and branch hospital between April 1986 and March 2016 were included in the present study...
November 10, 2016: Pediatric Surgery International
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