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Mucosal thickness

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https://www.readbyqxmd.com/read/28326646/effect-of-tempol-on-the-prevention-of-irradiation-induced-mucositisin-miniature-pigs
#1
Liang Hu, Yijuan Wang, Ana P Cotrim, Zhao Zhu, Runtao Gao, Changyu Zheng, Corinne M Goldsmith, Luyuan Jin, Chunmei Zhang, James B Mitchell, Bruce J Baum, Songlin Wang
OBJECTIVE: The goals of this study were to (i) establish a useful miniature pig (minipig) model for irradiation-induced oral mucositis and (ii) evaluate the effect of Tempol to prevent its development. METHODS AND MATERIALS: Minipigs were irradiated with 6Gy for 5 consecutive days targeting the entire oral cavity. To prevent radiation damage minipigs were treated with 30 mg/kg Tempol 10 minutes before irradiation (n=4), while, the radiation-alone group was similarly injected with saline (n=4)...
March 22, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28303674/simultaneous-recording-of-ultrasound-and-polysomnography-during-natural-sleep-in-patients-with-obstructive-sleep-apnea-a-pilot-study
#2
Jeng-Wen Chen, Chih-Chung Huang, Chi-Kai Weng, Chun-Hsiang Chang, Shou-Jen Wang
Tongue base deformation may play a critical role in the phenomenon of obstructive sleep apnea, but polysomnography provides limited information regarding the effect of tongue motion during natural sleep. We reported on preliminary results of combining a novel ultrasound system and polysomnography for simultaneous recordings during natural sleep in volunteers and patients with obstructive sleep apnea. All participants underwent time-synchronized polysomnography and submental transcutaneous ultrasound examinations...
March 17, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28303157/tangshen-formula-attenuates-colonic-structure-remodeling-in-type-2-diabetic-rats
#3
Pengmin Chen, Jingbo Zhao, Haojun Zhang, Xin Yang, Tingting Zhao, Huicun Zhang, Meihua Yan, Lin Pan, Xin Li, Yun Zhang, Ping Li
Aim. This study investigated the effect and mechanism of the Chinese herbal medicine Tangshen Formula (TSF) on GI structure remodeling in the rat model of diabetes. Methods. Type 2 diabetic rats were used. Wet weight per unit length, layer thicknesses, levels of collagens I and III, nuclear factor kappa B (NF-κB), interferon-γ (IFN-γ), interleukin-6 (IL-6), transforming growth factor-β1 (TGF-β1), and Smad2/3 expression in the rat colon were measured. Results. Compared with the control group animals, wet weight and layer thicknesses of the colon increased, and expressions of collagens I and III, NF-κB, IFN-γ, IL-6, TGF-β1, and Smad2/3 increased significantly in the diabetic animals...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28299261/crossed-pectoralis-major-myocutaneous-flap-for-recurrent-oral-cavity-cancers
#4
Mayank Pancholi, Sanjay Sharma, Sanjay M Desai, Deepak Agrawal
BACKGROUND: Oral cavity cancers are fairly common and have propensity to recur locally. Since Pectoralis Major Myocutaneous (PMMC) flap is the most widely used first flap for reconstruction, it is exhausted at the earliest and recurrence poses a formidable challenge for reconstructive surgeon. Present study evaluated the feasibility of contralateral Pectoralis Major Myocutaneous Flap for reconstruction after resection of recurrent tumour. METHODS: This was a study of the patients presenting with recurrent oral cavity cancer after exhausted ipsilateral Pectoralis Major Myocutaneous Flap (PMMC) in whom we used contralateral Pectoralis Major Myocutaneous Flap (Crossed PMMC Flap) for reconstruction between October 2013 to June 2016...
July 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28289870/the-effects-of-choanal-atresia-on-development-of-the-paranasal-sinuses-and-turbinates
#5
Suat Terzi, Engin Dursun, Fatma Beyazal Çeliker, Metin Çeliker, Mehmet Beyazal, Abdulkadir Özgür, Emel Çadallı Tatar, Mehmet Hakan Korkmaz
PURPOSE: The objective of this study was to evaluate the volume of paranasal sinuses (PNS) and turbinate in patients with unilateral choanal atresia (CA). MATERIALS AND METHOD: Computed tomography images of PNS in 11 individuals with unilateral CA were evaluated retrospectively. Mucosal thickness and volume of the maxillary, frontal and sphenoidal sinuses were determined, in addition to the volume of the middle and inferior turbinate. The unaffected nasal side of patients was used as a control group for the measurements...
March 13, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28281119/hybrid-endoscopic-mucosal-resection-and-full-thickness-resection-a-new-approach-for-resection-of-large-non-lifting-colorectal-adenomas-with-video
#6
Benjamin Meier, Karel Caca, Arthur Schmidt
BACKGROUND: Clip-assisted endoscopic full-thickness resection (EFTR) with an over-the-scope device has been recently described to be feasible and effective for the resection of non-lifting adenomas in the lower gastrointestinal tract. However, tumor size is the major limitation of that technique. We describe a hybrid technique using endoscopic mucosal resection (EMR) in ten patients with large non-lifting colorectal adenomas to reduce tumor size and facilitate clip-assisted EFTR. METHODS: Data of ten consecutive patients (median age 72...
March 9, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28277475/full-thickness-entire-nasal-alar-reconstruction-using-a-forehead-flap-in-asians-no-cartilaginous-infrastructural-lining-is-necessary
#7
Emi Funayama, Yuhei Yamamoto, Hiroshi Furukawa, Naoki Murao, Ryuji Shichinohe, Takeshi Yamao, Toshihiko Hayashi, Akihiko Oyama
Full-thickness defects of the entire nasal ala, including the rim, can be challenging to reconstruct. A forehead flap may provide a more imperceptible and natural-appearing reconstructed nasal ala. Previously, many authors have insisted adding cartilaginous infrastructural support for an entire, full-thickness defect to keep the postoperative alar structure symmetrical. They finally use a forehead flap after thinning of the distal covering portion subcutaneously, possibly for a Caucasian-type nasal ala. However, Asian skin has a thicker and more compact dermis than that of Caucasian skin, and the Asian ala is rounder and thicker...
March 8, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28274057/picrosirius-red-and-polarization-microscopy-a-tool-for-gender-differentiation
#8
Bk Charan Gowda, Ganganna Kokila, Pillai Arun Gopinathan, Kunigal Shivaprakash Praveen
INTRODUCTION: Forensic dentistry is a branch of dentistry which in collaboration with legal profession serves an important role to maintain justice system of a country. Forensic dentists play a major role in identification of an individual. Within the literature various methods have been found to be useful in gender differentiation. An attempt was made for differentiation of gender using picrosirius red and polarization microscopy. AIM: To evaluate picrosirius red and polarization microscopy as a tool for gender differentiation by observing birefringence pattern and distribution of thick and thin collagen fibers in males and females...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28271031/enteroendocrine-derived-glucagon-like-peptide-2-controls-intestinal-amino-acid-transport
#9
Jennifer Lee, Jacqueline Koehler, Bernardo Yusta, Jasmine Bahrami, Dianne Matthews, Mahroukh Rafii, Paul B Pencharz, Daniel J Drucker
OBJECTIVE: Glucagon-like peptide-2 (GLP-2) is co-secreted with GLP-1 from gut endocrine cells, and both peptides act as growth factors to expand the surface area of the mucosal epithelium. Notably, GLP-2 also enhances glucose and lipid transport in enterocytes; however, its actions on control of amino acid (AA) transport remain unclear. Here we examined the mechanisms linking gain and loss of GLP-2 receptor (GLP-2R) signaling to control of intestinal amino acid absorption in mice. METHODS: Absorption, transport, and clearance of essential AAs, specifically lysine, were measured in vivo by Liquid Chromatography triple quadrupole Mass Spectrometry (LC-MS/MS) and ex vivo with Ussing chambers using intestinal preparations from Glp2r(+/+) and Glp2r(-/-) mice...
March 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28265894/endoscopic-ultrasonography-features-of-gastric-mucosal-cobblestone-like-changes-from-a-proton-pump-inhibitor
#10
Shuichi Miyamoto, Takahiko Kudo, Mototsugu Kato, Kana Matsuda, Satoshi Abiko, Momoko Tsuda, Takeshi Mizushima, Keiko Yamamoto, Shoko Ono, Yuichi Shimizu, Naoya Sakamoto
A 68-year-old man with no symptoms presented to Hokkaido University Hospital for esophagogastroduodenoscopy screening. He had a history of Helicobacter pylori eradication. Initial esophagogastroduodenoscopy showed no gastric cobblestone-like mucosa or gastric cracked mucosa. After 1 year, he received esomeprazole (20 mg) once daily for heartburn at another hospital. Esophagogastroduodenoscopy was performed after 2 years of esomeprazole administration. Endoscopic findings showed that after H. pylori eradication, according to the Kyoto classification, gastric cobblestone-like mucosa presented in the gastric body area...
March 6, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28265231/comparison-between-cryoablation-and-irreversible-electroporation-of-rabbit-livers-at-a-location-close-to-the-gallbladder
#11
Jianying Zeng, Zilin Qin, Liang Zhou, Gang Fang, Jibing Chen, Jialiang Li, Lizhi Niu, Bing Liang, Kecheng Xu
BACKGROUND: The ablation of liver tumors located close to the gallbladder is likely to lead to complications. The aim of this article is to compare the safety and efficacy of irreversible electroporation (IRE) and cryoablation in rabbit livers at a location close to the gallbladder. MATERIALS AND METHODS: We performed cryoablation (n = 12) and IRE (n = 12) of the area of the liver close to the gallbladder in 24 New Zealand white rabbits in order to ensure gallbladder damage...
March 1, 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28260714/a-case-of-collagenous-colitis-associated-with-novel-oral-anticoagulants-use
#12
Juri Ikemoto, Kouichi Nakadoi, Seiji Onogawa, Motomitsu Fukuhara, Takayoshi Shishido, Keiji Hanada, Shuji Yonehara
An 84-year-old man was referred to our hospital because of watery diarrhea. Due to cerebral infarction, he had started treatment with a novel oral anticoagulants (NOAC) 1 month prior to admission. The patient underwent blood tests, enhanced computed tomography, and colonoscopy, which indicated infectious or medicinal colitis. The diarrhea persisted and he developed hypokalemia, so a second colonoscopy was performed, which showed edematous mucosa. Colonic mucosal biopsies showed a thick collagen band in the subepithelial region, and collagenous colitis was diagnosed...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28247222/update-from-the-4th-edition-of-the-world-health-organization-classification-of-head-and-neck-tumours-mucosal-melanomas
#13
Michelle D Williams
The updated edition of The World Health Organization Classification of Tumours of the Head and Neck includes discussions on mucosal melanoma of both the sinonasal and oral cavity. Since the prior edition, sinonasal origin is now recognized as the most common site of occurrence of mucosal melanoma in the head and neck (66%) with oral cavity representing 25% of cases. Histologic features of mucosal melanomas vary widely from spindled, epithelioid, and pleomorphic to rhabdoid, plasmacytoid and undifferentiated...
March 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28247060/rectal-advancement-flap-for-the-treatment-of-complex-cryptoglandular-anal-fistulas-a-systematic-review-and-meta-analysis
#14
REVIEW
Zutoia Balciscueta, Natalia Uribe, Izaskun Balciscueta, Juan Carlos Andreu-Ballester, Eduardo García-Granero
PURPOSE: Rectal advancement flap is an accepted approach for treating complex fistula-in-ano. However, a diversity of technical modifications have been described. The aim of this study was to evaluate recurrence and fecal continence rates after performing rectal advancement flaps depending upon flap thickness (full-thickness, partial-thickness, or mucosal flaps) and treatment of the fistulous tract (core-out or curettage). METHODS: Medline (PubMed, Ovid), the Cochrane Library database, and ClinicalTrials...
February 28, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28244147/a-genetic-female-mouse-model-with-congenital-genitourinary-anomalies-and-adult-stages-of-urinary-incontinence
#15
Pedram Akbari, Ali Fathollahi, Rong Mo, Michael Kavran, Nicole Episalla, Chi-Chung Hui, Walid A Farhat, Adonis K Hijaz
AIMS: To characterize the urinary incontinence observed in adult Gli2(+/)(-) ; Gli3(Δ699/+) female mice and identify the defects underlying the condition. METHODS: Gli2(+/)(-) and Gli3(Δ699/+) mice were crossed to generate: wild-type, mutant Gli2 (Gli2(+/-) ), mutant Gli3 (Gli3(Δ699/+) ), and double mutant (Gli2(+/-) ; Gli3(Δ699/+) ) female mice, verified via Polymerase Chain Reactions. Bladder functional studies including cystometrogram (CMG), leak point pressure (LPP), and voiding testing were performed on adult female mice...
February 28, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28226372/reconstruction-of-the-intranasal-lining
#16
Joseph Zenga, John J Chi
Reconstruction of full-thickness nasal defects has been the subject of surgical inquiry and innovation for over 2,000 years. The replacement of the internal nasal lining is a critical feature of complex nasal reconstruction. Successful reconstruction can prevent cicatricial contraction, external distortion, and internal stenosis. An array of reconstructive possibilities has been described, including cutaneous, mucosal, and fascial options. The challenge to the reconstructive surgeon is to select the repair that maximizes internal stability, while maintaining a patent nasal airway, minimizing morbidity, and meeting patient expectations...
February 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28210078/sex-differences-and-effects-of-oestrogen-in-rat-gastric-mucosal-defence
#17
Richard Shore, Håkan Björne, Yoko Omoto, Anna Siemiatkowska, Jan-Åke Gustafsson, Mats Lindblad, Lena Holm
AIM: To evaluate sex differences and the effects of oestrogen administration in rat gastric mucosal defence. METHODS: Sex differences in gastric mucus thickness and accumulation rate, absolute gastric mucosal blood flow using microspheres, the integrity of the gastric mucosal epithelium in response to a chemical irritant and the effects of oestrogen administration on relative gastric mucosal blood flow in an acute setting was assessed in an in vivo rat experimental model...
January 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28206943/limited-resection-of-the-duodenum-for-nonampullary-duodenal-tumors-with-review-of-the-literature
#18
REVIEW
Daisuke Hashimoto, Kota Arima, Akira Chikamoto, Katsunobu Taki, Risa Inoue, Takayoshi Kaida, Takaaki Higashi, Katsunori Imai, Toru Beppu, Hideo Baba
The surgical management of duodenal pathology is challenging because of its retroperitoneal position and shared blood supply with the pancreas. We present three types of limited resection of the duodenum for the removal of superficial or small nonampullary duodenal (NADL) lesions, and also a review of the English literature regarding management, such as endoscopic resection and limited duodenal resection. Ten cases underwent limited resections of the duodenum for superficial or small NADL lesions from 2011 to 2015...
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28191788/full-thickness-skin-mesh-graft-vaginoplasty-a-skin-sparing-technique
#19
Guilherme Lang Motta, Patric Machado Tavares, Gabriel Veber Moisés Silva, Milton Berger, Brasil Silva Neto, Tiago Elias Rosito
INTRODUCTION: The ideal vaginoplasty method should promote good cosmetic and functional results with low morbidity. We describe a new technique for congenital vaginal agenesis using a full-thickness perforated skin graft. MATERIALS AND METHODS: We report an 18 year old patient with vaginal agenesis (Morris syndrome) that undergone a modified version of McIndoe vaginoplasty. Patient is set in a low lithotomy position and lateral traction sutures are placed in labia and a 16Fr urethral catheter inserted...
January 27, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28185382/autogenous-bone-block-grafting-provides-facial-implant-tissue-stability-long-term
#20
Fernando Verdugo, Agurne Uribarri, Antonio D'Addona
BACKGROUND: Mucosal recession (MR) and bone loss can compromise anterior implant esthetics. PURPOSE: To evaluate tissue stability and clinical outcomes of anterior implants augmented with autogenous block transplants long-term. MATERIALS AND METHODS: This prospective cross-sectional clinical study analyzed facial tissue recession of anterior implants augmented with autogenous bone blocks and compared them to adjacent teeth in forty patients 52 months post-augmentation...
February 10, 2017: Clinical Implant Dentistry and related Research
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