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acute febrile illness

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https://www.readbyqxmd.com/read/28225519/a-cytokine-pattern-that-differentiates-preseroconversion-from-postseroconversion-phases-of-primary-hiv-infection
#1
Lucia Pastor, Erica Parker, Jorge Carrillo, Victor Urrea, Laura Fuente-Soro, Durval Respeito, Chenjerai Jairoce, Inacio Mandomando, Julià Blanco, Denise Naniche
BACKGROUND: During acute HIV infection, HIV actively replicates but seroconversion has not yet occurred. Primary HIV infection (PHI) is characterized by a transient nonspecific febrile illness, a massive inflammatory response, and the progressive appearance of anti-HIV-specific antibodies. In this study, we have identified patterns of inflammatory biomarkers associated with the innate immunological reaction before completion of a full humoral response. METHODS: A symptom-based screening was used to identify acute HIV infection in the Manhiça District Hospital in Mozambique...
April 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28222811/recurring-septic-shock-in-a-patient-with-blunt-abdominal-and-pelvic-trauma-how-mandatory-is-source-control-surgery-a-case-report
#2
Antonella Frattari, Giustino Parruti, Rocco Erasmo, Luigi Guerra, Ennio Polilli, Rosamaria Zocaro, Giuliano Iervese, Paolo Fazii, Tullio Spina
BACKGROUND: In critically ill patients with colonization/infection of multidrug-resistant organisms, source control surgery is one of the major determinants of clinical success. In more complex cases, the use of different tools for sepsis management may allow survival until complete source control. CASE PRESENTATION: A 42-year-old white man presented with traumatic hemorrhagic shock. Unstable pelvic fractures led to emergency stabilization surgery. Fever ensued with diarrhea, followed by septic shock...
February 22, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28218629/fever-induced-brugada-pattern-misdiagnosed-as-an-acute-myocardial-infarction
#3
David Tadin, Roberto Quintal
The Brugada syndrome is a rare condition associated with increased risk of ventricular tachyarrhythmias and sudden cardiac death (SCD). The Brugada pattern on electrocardiogram (EKG) is known to be revealed by several precipitants including febrile illnesses. The appearance of a Brugada pattern on EKG with fever may indicate an elevated risk of arrhythmia or sudden cardiac death. We report a case in which the electrocardiographic abnormality of Brugada pattern induced by sepsis was initially misinterpreted as a ST-segment elevation myocardial infarction (STEMI)...
January 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28217609/acute-pancreatitis-due-to-malaria-a-case-report-of-five-patients-and-review-of-literature
#4
Kundavaram Paul Prabhakar Abhilash, Atif Shaikh Iqbal Ahmed, Sowmya Sathyendra, Ooriapadickal Cherian Abraham
Malaria is endemic in large parts of India and can cause multiorgan failure and death. Acute pancreatitis as a complication is rare and is potentially fatal. This case series describes five adult patients between 2005 and 2010 who presented with a short duration febrile illness and diagnosed to have malaria with acute pancreatitis. The mean age of the five patients with acute pancreatitis was 40.4 years and four of them were males. None of them were alcohol consumers and did not have any other risk factor for acute pancreatitis...
July 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28217558/the-scid-mouse-model-for-identifying-virulence-determinants-in-coxiella-burnetii
#5
Erin J van Schaik, Elizabeth D Case, Eric Martinez, Matteo Bonazzi, James E Samuel
Coxiella burnetii is an intracellular, zoonotic pathogen that is the causative agent of Q fever. Infection most frequently occurs after inhalation of contaminated aerosols, which can lead to acute, self-limiting febrile illness or more serve chronic infections such as hepatitis or endocarditis. Macrophages are the principal target cells during infection where C. burnetii resides and replicates within a unique phagolysosome-like compartment, the Coxiella-containing vacuole (CCV). The first virulence determinant described as necessary for infection was full-length lipopolysaccarride (LPS); spontaneous rough mutants (phase II) arise after passage in immuno-incompetent hosts...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28202789/use-of-multiplex-real-time-pcr-to-diagnose-scrub-typhus
#6
Wiwit Tantibhedhyangkul, Ekkarat Wongsawat, Saowaluk Silpasakorn, Duangdao Waywa, Nuttawut Saenyasiri, Jintapa Suesuay, Wilawan Thipmontree, Yupin Suputtamongkol
Scrub typhus, caused by Orientia tsutsugamushi, is a common cause of acute undifferentiated febrile illness in the Asia--Pacific region. However, its non-specific clinical manifestation often prevents early diagnosis. We propose the use of PCR and serologic tests as diagnostic tools. Here, we developed a multiplex real-time PCR assay using hydrolysis (Taqman) probes targeting O. tsutsugamushi47-kDa, groEL, and human IFNB genes to improve early diagnosis of scrub typhus. The amplification efficiency was higher than 94%, and the lower detection limit was 10 copies per reaction...
February 15, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28195095/molecular-detection-of-orientia-tsutsugamushi-from-suspected-scrub-typhus-cases
#7
Seethalakshmi Srinivasan, Thangam Menon
CONTEXT: Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi. The disease is under-diagnosed in India, because of low index of suspicion and also due to its nonspecific presentation, and lack of confirmatory diagnostic tests. AIMS: This study was undertaken to diagnose scrub typhus in patients with undifferentiated fevers by serology and molecular methods. MATERIALS AND METHODS: A total of 68 blood samples were collected from patients clinically suspected to have scrub typhus...
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28174559/zika-virus-chikungunya-virus-and-dengue-virus-in-cerebrospinal-fluid-from-adults-with-neurological-manifestations-guayaquil-ecuador
#8
Nathalie Acevedo, Jesse Waggoner, Michelle Rodriguez, Lissette Rivera, José Landivar, Benjamin Pinsky, Hector Zambrano
Zika virus (ZIKV), chikungunya virus (CHIKV), and dengue virus (DENV) have been associated with clinical presentations that involve acute neurological complaints. In the current study, we identified ZIKV, CHIKV, and DENV in cerebrospinal fluid (CSF) samples from patients admitted to the Hospital Luis Vernaza (Guayaquil, Ecuador) to the Emergency Room or the Intensive Care Unit, with neurological symptoms and/or concern for acute arboviral infections. Viral RNA from one or more virus was detected in 12/16 patients...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28141801/distinct-antibody-responses-of-patients-with-mild-and-severe-leptospirosis-determined-by-whole-proteome-microarray-analysis
#9
Carolina Lessa-Aquino, Janet C Lindow, Arlo Randall, Elsio Wunder, Jozelyn Pablo, Rie Nakajima, Algis Jasinskas, Jaqueline S Cruz, Alcineia O Damião, Nívison Nery, Guilherme S Ribeiro, Federico Costa, José E Hagan, Mitermayer Galvão Reis, Albert I Ko, Marco Alberto Medeiros, Philip L Felgner
BACKGROUND: Leptospirosis is an important zoonotic disease worldwide. Humans usually present a mild non-specific febrile illness, but a proportion of them develop more severe outcomes, such as multi-organ failure, lung hemorrhage and death. Such complications are thought to depend on several factors, including the host immunity. Protective immunity is associated with humoral immune response, but little is known about the immune response mounted during naturally-acquired Leptospira infection...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28138049/clinical-manifestations-associated-with-peripheral-joint-involvement-in-patients-with-acute-chikungunya-virus-infection
#10
Mariangelí Arroyo-Ávila, Amanda Cabán, Enid J García-Rivera, Marisela Irizarry-Pérez, Hilda Torres, Héctor Gorbea, Luis M Vilá
Chikungunya virus (CHIKV) causes an acute febrile illness usually accompanied by severe polyarthralgia and polyarthritis. Previous studies have shown that older age, female gender, and some comorbid conditions are associated with chronic CHIKV arthritis. However, the factors associated with acute arthralgia and arthritis are not well known. Thus, we studied the clinical manifestations associated with acute peripheral joint involvement in a group of CHIKV patients from Puerto Rico. Patients with a history of fever for < 7 days evaluated at the emergency department of a university-based hospital were tested for several pathogens including CHIKV...
January 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28131646/resource-impact-of-managing-suspected-middle-east-respiratory-syndrome-patients-in-a-uk-teaching-hospital
#11
J Veater, N Wong, I Stephenson, H Kirk-Granger, L F Baxter, R Cannon, S Wilson, S Atabani, A Sahota, D Bell, M Wiselka, J W Tang
Clinical challenges exist in the management of hospitalized patients returning to the UK with potential Middle East respiratory syndrome coronavirus (MERS-CoV) infection, particularly with its clinical overlap with influenza, as demonstrated in this case-series and cost-analysis review of returning Hajj pilgrims. These patients were hospitalized with acute febrile respiratory illness, initially managed as potential MERS-CoV infections, but were eventually diagnosed with influenza. Additional costs were small, yet enhanced infection prevention measures created significant burdens on isolation rooms and staff time...
March 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28103905/spatio-temporal-analysis-of-the-genetic-diversity-and-complexity-of-plasmodium-falciparum-infections-in-kedougou-southeastern-senegal
#12
Makhtar Niang, Laty G Thiam, Cheikh Loucoubar, Abdourahmane Sow, Bacary D Sadio, Mawlouth Diallo, Amadou A Sall, Aissatou Toure-Balde
BACKGROUND: Genetic analyses of the malaria parasite population and its temporal and spatial dynamics could provide an assessment of the effectiveness of disease control strategies. The genetic diversity of Plasmodium falciparum has been poorly documented in Senegal, and limited data are available from the Kedougou Region. This study examines the spatial and temporal variation of the genetic diversity and complexity of P. falciparum infections in acute febrile patients in Kedougou, southeastern Senegal...
January 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28093542/disease-burden-of-dengue-in-the-philippines-adjusting-for-underreporting-by-comparing-active-and-passive-dengue-surveillance-in-punta-princesa-cebu-city
#13
Eduardo A Undurraga, Frances E Edillo, Jonathan Neil V Erasmo, Maria Theresa P Alera, In-Kyu Yoon, Francisco M Largo, Donald S Shepard
Dengue virus (DENV) is a serious threat to public health. Having reliable estimates of the burden of dengue is important to inform policy and research, but surveillance systems are not designed to capture all symptomatic DENV infections. We derived the rate of reporting of dengue by comparing active surveillance of symptomatic DENV infections in a prospective community-based seroepidemiological cohort study (N = 1008) of acute febrile illness in Punta Princesa, Cebu City, Philippines, with passive surveillance data from the Cebu City Health Department...
January 16, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28093537/dengue-epidemic-in-postconflict-swat-district-khyber-pakhtunkhwa-pakistan-2013
#14
Mamoona Chaudhry, Saeed Ahmad, Hamad Bin Rashid, Iftikhar Ud Din
Swat, a lush green valley of 1.3 million persons, remained under militant insurgency from 2007 to 2009, which damaged the health infrastructure. An outbreak of dengue fever (DF) was declared in the valley in 2013. To investigate this outbreak, we established active surveillance of national hospitals and private clinics, reviewed available clinical and laboratory records, and conducted entomological survey. From August to November 2013, 16,000 suspected patients with acute febrile illness were presented to health facilities...
January 16, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28092222/varied-presentations-of-leptospirosis-experience-from-a-tertiary-care-hospital-in-north-india
#15
Rama Chaudhry, Karnika Saigal, Tej Bahadur, Kamla Kant, Bishwanath Chourasia, Nitin Gupta
Leptospirosis has been recognised as an emerging global public health problem. The aim of our study was to explore the epidemiological and clinical pattern of disease occurrence in suspected cases and to search for any existing co-infections. Ours was a retrospective study in patients with acute febrile illness in north India over a period of three years (April 2011 to June 2014). Serological diagnosis of leptospirosis was made using the PanBio IgM ELISA kit. Using modified Faine's criteria, presumptive and possible diagnosis was made in 57% and 34% cases, respectively...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/28086810/genotypic-characterization-of-orientia-tsutsugamushi-from-patients-in-two-geographical-locations-in-sri-lanka
#16
Ranjan Premaratna, Lucas S Blanton, Dilhar N Samaraweera, G Nalika N de Silva, Nilmini T G A Chandrasena, David H Walker, H J de Silva
BACKGROUND: To date more than 20 antigenically distinct strains of Orientia tsutsugamushi (OT) reported within the tsutsugamushi triangle that cause an undifferentiated acute febrile illness in humans. Genotypic characterization of OT in different geographic regions or within the same country, is important in order to establish effective diagnostics, clinical management and to develop effective vaccines. Genetic and antigenic characterization of OT causing human disease in OT-endemic regions is not known for Sri Lanka...
January 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28072887/dengue-fever-in-travellers-and-risk-of-local-spreading-case-reports-from-southern-italy-and-literature-update
#17
Claudia Fabrizio, Luciana Lepore, Maria Chironna, Gioacchino Angarano, Annalisa Saracino
Dengue fever (DF), an arbovirosis caused by Dengue viruses (DV, serotypes 1-4), is responsible for an increasing number of travel-related acute febrile illnesses due to population growth, climate changes, spreading by viremic travellers, and improved laboratory diagnosis. The presence of efficient vectors (mosquito Aedes albopictus) has also been described in temperate regions including Italy which is considered the most heavily infected European country. Normally characterized by non-specific signs and symptoms, DF incidence is probably underestimated, especially in non-endemic countries, but the risk of severe forms is substantial...
January 2017: New Microbiologica
https://www.readbyqxmd.com/read/28069071/sporadic-cases-of-adult-measles-a-research-article
#18
Ranjan Premaratna, Nathasha Luke, Harsha Perera, Mahesh Gunathilake, Pubudu Amarasena, T G A Nilmini Chandrasena
BACKGROUND: Measles caused by a paramyxovirus, characterized by fever, malaise, cough, coryza conjunctivitis, a maculopapular rash is known to result in pneumonia, encephalitis and death. Fatal cases of measles in Sri Lanka are rare after implementation of the National Immunization Programme in 1984. Thereafter 0.1% case fatality rate was observed during October 1999-June 2000 which is a very low figure compared to other regional countries. Immunization guidelines were further revised in 2001, 2011 and in 2012 when additional immunization was recommended to age group 4-21 years; who are likely to have inadequate immunization, in order to achieve elimination of Measles by 2020...
January 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28065617/borrelia-miyamotoi-in-vectors-and-hosts-in-the-netherlands
#19
Alex Wagemakers, Seta Jahfari, Bob de Wever, Lodewijk Spanjaard, Markus V Starink, Henry J C de Vries, Hein Sprong, Joppe W Hovius
Ixodes ticks transmit Borrelia burgdorferi sensu lato (s.l.), the causative agent of Lyme borreliosis (LB). These tick species also transmit Borrelia miyamotoi, which was recently found to cause infections in humans. We were interested in the prevalence of B. miyamotoi infection in ticks and natural hosts in The Netherlands, and to what extent ticks are co-infected with B. burgdorferi. In addition, erythema migrans has been sporadically described in B. miyamotoi-infected patients, but these skin lesions might as well represent co-infections with B...
December 30, 2016: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28051359/electron-microscopy-of-alkhumra-hemorrhagic-fever-virus
#20
Tariq A Madani, El-Tayb M E Abuelzein, Sawsan M Jalalah, Huda Abu-Araki, Esam I Azhar, Ahmed M Hassan, Hussein M S Al-Bar
Alkhumra hemorrhagic fever virus (AHFV) is a newly described zoonotic flavivirus that was first isolated during 1994-1995 from the Alkhumra district south of Jeddah, Saudi Arabia. Subsequently, the virus was also isolated from Makkah city (2001-2003) and Najran (2008-2009), Saudi Arabia. The virus causes acute febrile illness with hepatitis, hemorrhagic manifestations, and encephalitis. A case fatality rate of 25% was reported among hospitalized patients. Although several biological and molecular characteristics of the virus have been published, no data are available on electron microscopic features of the virus...
January 4, 2017: Vector Borne and Zoonotic Diseases
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