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https://www.readbyqxmd.com/read/28635208/association-of-clinical-characteristics-of-patients-presenting-with-influenza-like-illness-or-severe-acute-respiratory-illness-with-development-of-acute-respiratory-distress-syndrome
#1
Muhammad Ijaz, Muhammad Jaffar Khan, Jawad Khan, Usama Usama
Clinical judgement and suspicion of influenza based on signs and symptoms of influenza-like illness and severe acute respiratory illness are critical for better patient outcome. Whether clinical characteristics of patients are associated with the development of acute respiratory distress syndrome and PCR positivity of samples was the aim of this study. We included all patients (n=37) presenting with influenza like illness (ILI) or severe acute respiratory illness (SARI) to a tertiary care hospital in northwest Pakistan during December 2015 until the end of January 2016...
May 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28629372/novel-nbas-mutations-and-fever-related-recurrent-acute-liver-failure-in-chinese-children-a-retrospective-study
#2
Jia-Qi Li, Yi-Ling Qiu, Jing-Yu Gong, Li-Min Dou, Yi Lu, A S Knisely, Mei-Hong Zhang, Wei-Sha Luan, Jian-She Wang
BACKGROUND: Underlying causes in Chinese children with recurrent acute liver failure (RALF), including liver crises less than full acute liver failure, are incompletely understood. We sought to address this by searching for genes mutated in such children. METHODS: Five unrelated Chinese boys presenting between 2012 and 2015 with RALF of unexplained etiology were studied. Results of whole exome sequencing were screened for mutations in candidate genes. Mutations were verified in patients and their family members by Sanger sequencing...
June 19, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28620811/serological-molecular-and-clinical-correlates-of-dengue-from-a-tertiary-care-centre-in-chennai-india
#3
Vigna Seshan, Gopalsamy Sarangan, Khaleefathullah Sheriff, Kaveri Krishnasamy, Gunasekaran Palani, Padma Srikanth
Dengue disease is caused by dengue viruses 1-4 and has been ranked by the World Health Organisation (WHO) as the fastest spreading vector-borne viral disease. Dengue is often underreported and misdiagnosed due to a wide spectrum of clinical manifestations. Diagnosis of dengue is based on clinical case definitions and laboratory methods. Newer case definitions of dengue have been formulated by clinical studies in order to improve case detection. Owing to its epidemic potential, mortality and morbidity, there is a need for a rapid and accurate diagnostic assay for dengue in order to help the clinician in the early detection of cases and to prevent disease progression...
June 16, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28619306/management-of-viral-oral-ulcers-in-children-using-chinese-herbal-medicine-a-report-of-two-cases
#4
Yi-Chiao Lee, Ting-Hao Wang, Shih-Yu Chen, Hsiang-Ling Lin, Ming-Yen Tsai
OBJECTIVE: Viral oral ulcers are common presentations in pediatric clinics. Although self-limiting, painful ulcerative lesions and inflamed mucosa can decrease oral intake and lead to dehydration. Despite the widespread use of Chinese herbal medicine (CHM) for pediatric upper respiratory disease in Taiwan, there is little evidence for its effectiveness as an antipyretic or in aiding ulcer healing for children with viral oral ulcers. We report two cases of children who presented with viral oral ulcers to illustrate the potential efficacy of CHM treatment in recovery from herpangina (HA) and herpetic gingivostomatitis (HGS)...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28607239/scrub-typhus-in-bhutan-a-synthesis-of-data-from-2009-to-2014
#5
REVIEW
Tshokey Tshokey, Tashi Choden, Ragunath Sharma
Scrub typhus is an acute, febrile illness, caused by the bacterium Orientia tsutsugamushi, that affects millions annually in the endemic Asia-Pacific region. In untreated cases, the case-fatality rates range from 6% to 35%. In Bhutan, there was a probable outbreak in Gedu in 2009, which resulted in heightened awareness of the disease. Nevertheless, information on scrub typhus in Bhutan is limited and scattered and the epidemiology has yet to be established. To report the current picture of scrub typhus in Bhutan, this review gathered data from scholarly databases, surveillance reports, the Annual health bulletin, research publications and laboratory test reports from hospitals...
September 2016: WHO South-East Asia Journal of Public Health
https://www.readbyqxmd.com/read/28601976/zika-virus-as-an-emerging-neuropathogen-mechanisms-of-neurovirulence-and-neuro-immune-interactions
#6
REVIEW
Gerwyn Morris, Tatiana Barichello, Brendon Stubbs, Cristiano A Köhler, André F Carvalho, Michael Maes
Zika virus (ZIKV) is an emerging arbovirus of the genus Flaviviridae, which causes a febrile illness and has spread from across the Pacific to the Americas in a short timeframe. Convincing evidence has implicated the ZIKV to incident cases of neonatal microcephaly and a set of neurodevelopmental abnormalities referred to as the congenital Zika virus syndrome. In addition, emerging data points to an association with the ZIKV and the development of the so-called Guillain-Barre syndrome, an acute autoimmune polyneuropathy...
June 11, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28593634/first-isolation-of-rickettsia-monacensis-from-a-patient-south-korea
#7
Yeon-Sook Kim, Yeon-Joo Choi, Kyung-Min Lee, Kyu-Joong Ahn, Heung-Chul Kim, Terry Klein, Ju Jiang, Allen Richards, Kyung-Hee Park, Won-Jong Jang
A Rickettsia sp. was isolated from blood of a patient with acute febrile illness using the shell vial technique and the isolate was named as CN45Kr. The CN45Kr was identified as Rickettsia monacensis, which was recognized as a pathogen for the first time in Spain, by molecular assay. In sequencing analysis, gltA sequence of the isolate was identical to those of Rickettsia sp. IRS3. The ompA-5' fragment sequence showed 100% identity to R. monacensis and Rickettsia sp. In56 and ompA-3' fragments showed 99.9% similarity to Rickettsia sp...
June 7, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28585301/analysis-of-complete-genome-sequence-and-major-surface-antigens-of-neorickettsia-helminthoeca-causative-agent-of-salmon-poisoning-disease
#8
Mingqun Lin, Katherine Bachman, Zhihui Cheng, Sean C Daugherty, Sushma Nagaraj, Naomi Sengamalay, Sandra Ott, Al Godinez, Luke J Tallon, Lisa Sadzewicz, Claire Fraser, Julie C Dunning Hotopp, Yasuko Rikihisa
Neorickettsia helminthoeca, a type species of the genus Neorickettsia, is an endosymbiont of digenetic trematodes of veterinary importance. Upon ingestion of salmonid fish parasitized with infected trematodes, canids develop salmon poisoning disease (SPD), an acute febrile illness that is particularly severe and often fatal in dogs without adequate treatment. We determined and analysed the complete genome sequence of N. helminthoeca: a single small circular chromosome of 884 232 bp encoding 774 potential proteins...
July 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28584297/increased-risk-of-influenza-among-vaccinated-adults-who-are-obese
#9
S D Neidich, W D Green, J Rebeles, E A Karlsson, S Schultz-Cherry, T L Noah, S Chakladar, M G Hudgens, S S Weir, M A Beck
BACKGROUND: Influenza infects 5-15% of the global population each year, and obesity has been shown to be an independent risk factor for increased influenza-related complications including hospitalization and death. However, the risk of developing influenza or ILI in a vaccinated obese adult population has not been addressed. OBJECTIVE: This study evaluated whether obesity was associated with increased risk of influenza and influenza-like illness among vaccinated adults...
June 6, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28580712/kawasaki-disease-state-of-the-art
#10
Jane W Newburger
Kawasaki disease is an acute febrile arteritis of childhood that can result in coronary artery aneurysms if untreated in the first 10 and ideally 7 days of illness. Kawasaki disease begins as a necrotizing arteritis with neutrophilic infiltrate, followed by subacute/chronic changes and luminal myofibroblastic proliferation that can cause coronary artery stenosis. Manifestations include the presence of ≥5 days of fever, together with clinical criteria of extremity changes, rash, conjunctivitis, oral changes, and unilateral cervical lymphadenopathy...
June 5, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28578700/a-rare-presentation-of-an-acute-abdomen-an-ileal-diverticular-perforation
#11
Basuru Uvindu Thilakawardana, Sanjay De Mel, Vasitha Abeysuriya, Janaki Hewavisenthi, Chandima De Mel, Lal Chandrasena, Visula Abeysuriya
BACKGROUND: This case report highlights the value of prompt intervention of diagnostic laparoscopy in a patient suspects of having an acute abdomen due to an intestinal perforation, where there is a limitation of performing Contrast Enhanced Computed Tomography of abdomen. A previously healthy young adult presenting with an acute abdomen due to a spontaneous ileal perforation, without any associated risk factors is a rare clinical entity in a developing country. Therefore, entertaining an early diagnosis will possibly prevent a fatal consequence...
June 2, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28553605/management-of-glycemia-in-acute-febrile-illness
#12
REVIEW
Sanjay Kalra, Sameer Aggarwal, Deepak Khandelwal, Deep Dutta
With increasing the prevalence of diabetes and prediabetes across the globe, a large number of patients with acute febrile illness (AFI) are likely to have concomitant diabetes or stress hyperglycemia. Management of associated hyperglycemia in patients with AFI is of utmost importance for early recovery and to prevent complications. There is no published literature, detailing the strategies and targets for glycemic control in AFI specifically; however, guidelines do exist for the management of hyperglycemia in hospitalized or outpatients in general...
May 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28542661/-benign-acute-childhood-myositis-clinical-series-and-literature-review
#13
Felipe Cavagnaro S M, Alejandra Aird G, Ingrid Harwardt R, Carmen Gloria Marambio Q
Benign acute childhood myositis (BACM) is a rare clinical condition that mainly affects pre-school and school age-children. It is usually preceded by a viral illness, particularly influenza virus infection. OBJECTIVE: To describe a cluster of BACM cases that were seen in a paediatric unit. PATIENTS AND METHODS: A retrospective series of cases that presented with a clinical picture suggestive of BACM between August and November 2012 in the paediatric emergency department of a private clinic...
April 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28523438/reversible-splenial-lesions-presenting-in-conjunction-with-febrile-illness-a-case-series-and-literature-review
#14
David Lin, Matthew Rheinboldt
Transient restricted diffusion and increased T2 signal intensity within the splenium of the corpus callosum is an increasingly recognized albeit uncommon imaging feature in the setting of acute encephalitis and antecedent viral illness. This review will discuss three index cases obtained from an institutional databank. Additionally, the current understanding of the underlying neurophysiologic pathogenesis will be discussed together with differential clinical and imaging diagnostic considerations, treatment options, and outcome metrics...
May 18, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28522338/year-round-influenza-immunisation-during-pregnancy-in-nepal-a-phase-4-randomised-placebo-controlled-trial
#15
Mark C Steinhoff, Joanne Katz, Janet A Englund, Subarna K Khatry, Laxman Shrestha, Jane Kuypers, Laveta Stewart, Luke C Mullany, Helen Y Chu, Steven C LeClerq, Naoko Kozuki, Monica McNeal, Adriana M Reedy, James M Tielsch
BACKGROUND: Influenza immunisation during pregnancy is recommended but not widely implemented in some low-income regions. We assessed the safety and efficacy in mothers and infants of year-round maternal influenza immunisation in Nepal, where influenza viruses circulate throughout the year. METHODS: In this phase 4, randomised, placebo-controlled trial, we enrolled two consecutive sequential annual cohorts of pregnant women from the Sarlahi district in southern Nepal...
May 15, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28520981/clinical-presentation-and-outcomes-of-children-with-human-granulocytic-anaplasmosis
#16
Anna M Schotthoefer, Matthew C Hall, Satya Vittala, Raza Bajwa, Holly M Frost
Background.: Adults with the tick-borne disease human granulocytic anaplasmosis (HGA) have a spectrum of acute febrile illnesses that, if untreated, might be severe. Clinical presentation and outcomes of children with HGA have been poorly described. Methods.: A retrospective analysis was conducted to determine the frequency, presentation, and outcomes of pediatric patients with HGA between 1994 and 2015 in a region of Wisconsin in which HGA is highly endemic. Patients with related International Classification of Diseases Ninth and Tenth Revision (ICD-9 and ICD-10, respectively) codes or positive HGA laboratory test results were evaluated and classified as having had confirmed, probable, or suspected HGA on the basis of the Centers for Disease Control and Prevention (CDC) case definition...
May 16, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28483396/early-diagnosis-of-capos-syndrome-before-acute-onset-ataxia-review-of-the-literature-and-a-new-family
#17
Anna Duat Rodriguez, Michaela Prochazkova, Saturnino Santos Santos, Oscar Rubio Cabezas, Veronica Cantarin Extremera, Luis Gonzalez-Gutierrez-Solana
BACKGROUND: CAPOS syndrome (cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss) is a rare disease that has been reported in 22 patients so far. In all cases, the mutation c.2452G>A (p.Glu818Lys) in the ATP1A3 gene was identified. Patients typically present at an early age with an acute-onset fever-induced episode of ataxia frequently associated with encephalopathy and weakness. They usually present one to three episodes. The acute symptoms improve within days, but most patients show slow progression afterward...
June 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28480664/clinical-and-genetic-features-of-coxiella-burnetii-in-a-patient-with-an-acute-febrile-illness-in-korea
#18
Seung Hun Lee, Jung Yeon Heo, Hae Kyung Lee, Yeong Seon Lee, Hye Won Jeong, Seon Do Hwang
Although Q fever is an important zoonotic infection with a worldwide distribution, no human isolates of Coxiella burnetii have been identified in Korea. For the first time, we identified the nucleotide sequence of C. burnetii from a 32-year-old man with an acute febrile illness in Korea. Diagnosis of acute Q fever was confirmed by seroconversion using indirect immunofluorescence antibody assays. Phylogenetic analysis demonstrated high sequence similarity (99.6%-100%) with C. burnetii 16S rRNA sequences identified from the reservoir...
June 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28474627/scrub-typhus-in-uttarakhand-adjoining-uttar-pradesh-seasonality-clinical-presentations-predictors-of-mortality
#19
Anurag Bhargava, Reshma Kaushik, Rajeev Mohan Kaushik, Anita Sharma, Sohaib Ahmad, Minakshi Dhar, Garima Mittal, Sushant Khanduri, Priyannk Pant, Rajesh Kakkar
BACKGROUND & OBJECTIVES: Scrub typhus is a re-emerging mite-borne rickettsiosis, which continues to be underdiagnosed, with lethal consequences. The present study was conducted to determine the seasonality, clinical presentation and predictors of mortality in patients with scrub typhus at a tertiary care teaching hospital in northern India. METHODS: Scrub typhus was suspected in patients attending the hospital as per the standard case definition and serological evidence was obtained by performing an IgM ELISA...
December 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28468882/serum-metabolomics-investigation-of-humanized-mouse-model-with-dengue-infection
#20
Liang Cui, Jue Hou, Jinling Fang, Yie Hou Lee, Vivian Vasconcelos Costa, Lan Hiong Wong, Qingfeng Chen, Eng Eong Ooi, Steven R Tannenbaum, Jianzhu Chen, Choon Nam Ong
Dengue is an acute febrile illness caused by dengue virus (DENV) and a major cause of morbidity and mortality in tropical and subtropical regions of the world. The lack of an appropriate small-animal model of dengue infection has greatly hindered the study of dengue pathogenesis and the development of therapeutics. In this study, we conducted a mass spectrometry-based serum metabolic profiling from a humanized mice (humice) model with DENV serotype 2 infection at 0, 3, 7, 14 and 28 days post infection (dpi)...
May 3, 2017: Journal of Virology
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