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Wen-Chyuan Chen, Yi-Ming Chen, Chi-Chang Huang, Yen-Dun Tzeng
Dehydroepiandrosterone (DHEA), the most abundant sex steroid, is primarily secreted by the adrenal gland and a precursor hormone used by athletes for performance enhancement. Whole-body vibration (WBV) is a well-known light-resistance exercise by automatic adaptations to rapid and repeated oscillations from a vibrating platform, which is also a simple and convenient exercise for older adults. However, the potential effects of DHEA supplementation combined with WBV training on to body composition, exercise performance, and hormone regulation are currently unclear...
2016: International Journal of Medical Sciences
Theresa Pauly, Jennifer C Lay, Urs M Nater, Stacey B Scott, Christiane A Hoppmann
BACKGROUND: Spending time alone constitutes a ubiquitous part of our everyday lives. As we get older, alone time increases. Less is known, however, about age differences in the experience of spending time alone (momentary solitude). OBJECTIVES: We examined time-varying associations between momentary solitude, affect quality, and two hypothalamic-pituitary-adrenal axis activity markers [salivary cortisol; dehydroepiandrosterone sulfate (DHEAs)] to better understand the affective and biological correlates of momentary solitude across the adult life span...
October 20, 2016: Gerontology
Sankar N Maity, Mark A Titus, Revekka Gyftaki, Guanglin Wu, Jing-Fang Lu, S Ramachandran, Elsa M Li-Ning-Tapia, Christopher J Logothetis, John C Araujo, Eleni Efstathiou
Cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17A1) is a validated treatment target for the treatment of metastatic castration-resistant prostate cancer (CRPC). Abiraterone acetate (AA) inhibits both 17α-hydroxylase (hydroxylase) and 17,20-lyase (lyase) reactions catalyzed by CYP17A1 and thus depletes androgen biosynthesis. However, coadministration of prednisone is required to suppress the mineralocorticoid excess and cortisol depletion that result from hydroxylase inhibition. VT-464, a nonsteroidal small molecule, selectively inhibits CYP17A1 lyase and therefore does not require prednisone supplementation...
October 17, 2016: Scientific Reports
Maria Magdalena Montt-Guevara, Jorge Eduardo Shortrede, Maria Silvia Giretti, Andrea Giannini, Paolo Mannella, Eleonora Russo, Alessandro David Genazzani, Tommaso Simoncini
The relationship between androgens and breast cancer is controversial. Androgens have complex effects on breast cancer progression and metastasis. Moreover, androgen receptor (AR) is expressed in approximately 70 to 90% of invasive breast carcinomas, which has prognostic relevance in basal-like cancers and in triple-negative breast cancers. Recent studies have associated the actin-binding proteins of the ezrin-radixin-moesin (ERM) family with metastasis in endocrine-sensitive cancers. We studied on T47D breast cancer cells whether androgens with different characteristics, such as testosterone (T), dihydrotestosterone (DHT), and dehydroepiandrosterone (DHEA) may regulate breast cancer cell motility and invasion through the control of actin remodeling...
2016: Frontiers in Endocrinology
Alexander J Frey, Qingqing Wang, Christine Busch, Daniel Feldman, Lisa Bottalico, Clementina A Mesaros, Ian A Blair, Anil Vachani, Nathaniel W Snyder
A multiplexed quantitative method for the analysis of three major unconjugated steroids in human serum by stable isotope dilution liquid chromatography-high resolution mass spectrometry (LC-HRMS) was developed and validated on a Q Exactive Plus hybrid quadrupole/Orbitrap mass spectrometer. This quantification utilized isotope dilution and Girard P derivatization on the keto-groups of testosterone (T), androstenedione (AD) and dehydroepiandrosterone (DHEA) to improve ionization efficiency using electrospray ionization...
October 13, 2016: Steroids
Batool Hossein Rashidi, Mansoureh Gorginzadeh, Soroush Aalipour, Eric Scott Sills
Objective: To compare serum anti-Müllerian hormone (AMH) and other endocrine parameters between patients diagnosed with polycystic ovary syndrome (PCOS) and age-matched ovulatory women. Materials and methods: AMH, DHEAS, FSH, LH, PRL, TSH and total testosterone (TT) were prospectively measured in oligo-ovulatory PCOS patients (n = 595) and in ovulatory non-PCOS women (n = 157) referred to a tertiary infertility center. Mean BMI was similar across the two study populations and there were no smokers in the sample...
October 10, 2016: Archives of Endocrinology and Metabolism
K G Sorwell, L Renner, A R Weiss, M Neuringer, S G Kohama, H F Urbanski
Estradiol supplementation has been shown to enhance cognitive performance in old ovariectomized rhesus macaques (Macaca mulatta). To determine if similar benefits could be achieved in perimenopausal animals using alternative hormonal supplements we administered dehydroepiandrosterone (DHEA) to old ovary-intact female rhesus macaques for ~2.5 months. Using computerized touchscreen memory tasks, including delayed response (DR) and delayed matching-to-sample (DMS), we observed improved performance with time in all of the animals but failed to detect a significant effect of DHEA...
October 13, 2016: Genes, Brain, and Behavior
Min Jae Kang, Jeong Seon Lee, Hwa Young Kim, Hae Woon Jung, Young Ah Lee, Sun Hee Lee, Ji-Young Seo, Jae Hyun Kim, Hye Rim Chung, Se Young Kim, Choong Ho Shin, Sei Won Yang
The CAG repeat length of the androgen receptor (AR) gene, which exhibits an inverse relationship to AR sensitivity, might influence the development of the pubarche along with hyperandrogenemia. There are ethnic differences in the AR CAG repeat length, however, no Asian studies on premature pubarche (PP) have been reported, including Korea. Our objectives were to examine the hormone levels and AR CAG repeat length, and to assess their contributions to PP in Korean girls. Subjects with PP (n=16) and normal pubarche (NP, n=16), and normal controls (NC, n=16) were enrolled...
October 6, 2016: Endocrine Journal
Kemal Atasayan, Tevfik Yoldemir, Sedef Ramoglu, Dilek Gogas Yavuz
OBJECTIVE: To evaluate the endothelial function and structure in patients with hirsutism in reproductive age. STUDY DESIGN: The study was conducted on 69 consecutive women admitted with complaints of hirsutism and 63 voluntary healthy women, as controls. A total of 132 subjects who applied to the Gynecology and Infertility Outpatient Clinics were included. Participants with modified Ferriman Gallway (mFG) score over 8 were considered to be hirsute. The demographic, metabolic, hormonal characteristics, risk factors of cardiovascular disease, CIMT (carotis intima media thickness) and FMD (flow-mediated dilatation) were compared between hirsute women and those in the control group...
October 3, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Sónia do Vale, Lenka Selinger, João Martin Martins, Manuel Bicho, Isabel do Carmo, Carles Escera
Several studies have suggested that dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) may enhance working memory and attention, yet current evidence is still inconclusive. The balance between both forms of the hormone might be crucial regarding the effects that DHEA and DHEAS exert on the central nervous system. To test the hypothesis that higher DHEAS-to-DHEA ratios might enhance working memory and/or involuntary attention, we studied the DHEAS-to-DHEA ratio in relation to involuntary attention and working memory processing by recording the electroencephalogram of 22 young women while performing a working memory load task and a task without working memory load in an audio-visual oddball paradigm...
October 4, 2016: Neuroscience Letters
Edgar Flores-Soto, Jorge Reyes-García, Abril Carbajal-García, Elías Campuzano-González, Mercedes Perusquía, Bettina Sommer, Luis M Montaño
: Testosterone (TES), other androgens and female sex steroids induce non-genomic rapid relaxing effects in airway smooth muscle (ASM). In guinea pig ASM, basal tension was relaxed by dehydroepiandrosterone (DHEA) and TES; 17β-estradiol (E2) had a small effect. Blockers of L-type voltage dependent Ca(2+) channel (L-VDCC, D-600) and store operated Ca(2+) channel (SOC, 2-APB) also relaxed the basal tone. In tracheal myocytes, DHEA and TES diminished intracellular basal Ca(2+) concentrations (b[Ca(2+)]i) as D-600+2-APB but to a higher extend...
October 4, 2016: Molecular and Cellular Endocrinology
Marjaana Viljanto, James Scarth, Pamela Hincks, Lynn Hillyer, Adam Cawley, Craig Suann, Glenys Noble, Christopher J Walker, Andrew T Kicman, Mark C Parkin
Detection of testosterone and/or its pro-drugs in the gelding is currently regulated by the application of an international threshold for urinary testosterone of 20 ng/mL. The use of steroid ratios may provide a useful supplementary approach to aid in differentiating between the administration of these steroids and unusual physiological conditions that may result in atypically high testosterone concentrations. In the current study, an ultra high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method was developed to quantify testosterone (T) and epitestosterone (E)...
October 7, 2016: Drug Testing and Analysis
Kelly E Glajch, Laura Ferraiuolo, Kaly A Mueller, Matthew J Stopford, Varsha Prabhkar, Achille Gravanis, Pamela J Shaw, Ghazaleh Sadri-Vakili
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease caused by loss of motor neurons. ALS patients experience rapid deterioration in muscle function with an average lifespan of 3-5 years after diagnosis. Currently, the most effective therapeutic only extends lifespan by a few months, thus highlighting the need for new and improved therapies. Neurotrophic factors (NTFs) are important for neuronal development, maintenance, and survival. NTF treatment has previously shown efficacy in pre-clinical ALS models...
2016: PloS One
Márcio Silveira Corrêa, Bruno Lima Giacobbo, Kelem Vedovelli, Daiane Borba de Lima, Pamela Ferrari, Irani Iracema de Lima Argimon, Julio Cesar Walz, Elke Bromberg
OBJECTIVES: Older familial caregivers of Alzheimer's disease patients are subjected to stress-related cognitive and psychophysiological dysfunctions that may affect their quality of life and ability to provide care. Younger caregivers have never been properly evaluated. We hypothesized that they would show qualitatively similar cognitive and psychophysiological alterations to those of older caregivers. METHOD: The cognitive measures of 17 young (31-58 years) and 18 old (63-84 years) caregivers and of 17 young (37-57 years) and 18 old (62-84 years) non-caregiver controls were evaluated together with their salivary cortisol and dehydroepiandrosterone (DHEA) levels, as measured by radioimmunoassays and ELISA assays of brain-derived neurotrophic factor (BDNF) in serum...
2016: PloS One
Lisandra L Martin, Clemens Kubeil, Alexandr N Simonov, Vladimir L Kuznetsov, C Jo Corbin, Richard J Auchus, Alan J Conley, Alan M Bond, Raymond J Rodgers
Within the superfamily of cytochrome P450 enzymes (P450s), there is a small class which is functionally employed for steroid biosynthesis. The enzymes in this class appear to have a small active site to accommodate the steroid substrates specifically and snuggly, prior to the redox transformation or hydroxylation to form a product. Cytochrome P450c17 is one of these and is also a multi-functional P450, with two activities, the first 17α-hydroxylation of pregnenolone is followed by a subsequent 17,20-lyase transformation to dehydroepiandrosterone (DHEA) as the dominant pathways to cortisol precursors or androgens in humans, respectively...
October 3, 2016: Molecular and Cellular Endocrinology
Laura E Dichtel, Melanie Schorr, Corey M Gill, Konstantinos P Economopoulos, Anu V Gerweck, Brooke Swearingen, Richard Hodin, Miriam A Bredella, Karen K Miller
Hypercortisolemia is associated with abdominal adiposity. Prior studies have quantified visceral adipose tissue (VAT) versus subcutaneous adipose tissue (SAT) accumulation as assessed by CT and MRI in patients with pituitary Cushing's disease (1-3) but not of other etiologies. Hormone differences in women with Cushing's syndrome due to pituitary versus adrenal and iatrogenic etiologies, including differences in DHEA production, may affect body composition. This article is protected by copyright. All rights reserved...
October 3, 2016: Clinical Endocrinology
Kathrine Eggers Pedersen, Robert J Letcher, Christian Sonne, Rune Dietz, Bjarne Styrishave
Per- and polyfluoroalkyl substances (PFASs) are emerging in the Arctic and accumulate in brain tissues of East Greenland (EG) polar bears. In vitro studies have shown that PFASs might possess endocrine disrupting abilities and therefore the present study was conducted to investigate potential PFAS induced alterations in brain steroid concentrations. The concentrations of eleven steroid hormones were determined in eight brain regions from ten EG polar bears. Pregnenolone (PRE), the dominant progestagen, was found in mean concentrations of 5-47ng/g (ww) depending on brain region...
September 27, 2016: Environment International
K Hartmann, J Bennien, B Wapelhorst, K Bakhaus, V Schumacher, S Kliesch, W Weidner, M Bergmann, J Geyer, D Fietz
Within the human testis, large amounts of sulfated steroid hormones are produced. As shown in breast tissue and placenta, these might not only be excretion intermediates, but re-activated in target cells by steroid sulfatase (STS). This process is called sulfatase pathway and may play a pivotal role in para- and/or intracrine regulation by creating a local supply for steroid hormones. This requires a facilitated transport via uptake carriers and efflux transporters as these hydrophilic molecules cannot pass the cell membrane...
September 29, 2016: Histochemistry and Cell Biology
Li-Te Lin, Peng-Hui Wang, San-Nung Chen, Chia-Jung Li, Zhi-Hong Wen, Jiin-Tsuey Cheng, Kuan-Hao Tsui
BACKGROUND: Growing studies have demonstrated that dehydroepiandrosterone (DHEA) may improve fertility outcomes in poor ovarian responders (PORs). The aim of this study was to compare clinical outcomes and cumulus cell (CC) expression before and after DHEA treatment in PORs undergoing in vitro fertilization (IVF) cycles. METHODS: Six patients with poor ovarian response were enrolled in the study according to Bologna criteria. DHEA was supplied at least 2 months before patients entered into the next IVF cycle...
August 12, 2016: Gynecological Endocrinology
Amy A Lubik, Mannan Nouri, Sarah Truong, Mazyar Ghaffari, Hans H Adomat, Eva Corey, Michael E Cox, Na Li, Emma S Guns, Parvin Yenki, Steven Pham, Ralph Buttyan
Despite the substantial benefit of androgen deprivation therapy (ADT) for metastatic prostate cancer, patients often progress to castration-resistant disease (CRPC) that is more difficult to treat. CRPC is associated with renewed androgen receptor activity in tumor cells and restoration of tumor androgen levels through acquired intratumoral steroidogenesis (AIS). Although prostate cancer (PCa) cells have been shown to have steroidogenic capability in vitro, we previously found that benign prostate stromal cells (PrSCs) can also synthesize testosterone (T) from an adrenal precursor, DHEA, when stimulated with a hedgehog (Hh) pathway agonist, SAG...
September 27, 2016: International Journal of Cancer. Journal International du Cancer
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