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https://www.readbyqxmd.com/read/27911021/a-rapid-and-simple-liquid-chromatography-tandem-mass-spectrometry-method-for-the-measurement-of-testosterone-androstenedione-and-dehydroepiandrosterone-in-human-serum
#1
Wenjuan Xu, Huijun Li, Qing Guan, Ying Shen, Liming Cheng
BACKGROUND: The assay of androgens plays an important role for the differential diagnosis of androgen-related endocrine diseases. We developed a rapid and simple liquid chromatography tandem mass spectrometry (LC-MS/MS) method with small sample volume and simple sample preparation for simultaneous determination of serum testosterone, androstenedione and dehydroepiandrosterone (DHEA) in adults. METHODS: We spiked 100 μL of serum with 200 μL of internal standard solution, which was prepared in methanol, for matrix effect relief and protein precipitation...
December 2, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27910716/persistent-amenorrhea-and-decreased-dheas-to-cortisol-ratio-after-recovery-from-anorexia-nervosa
#2
Alessandra Andrisani, Chiara Sabbadin, Silvia Minardi, Angela Favaro, Gabriella Donà, Luciana Bordin, Guido Ambrosini, Decio Armanini
Persistent amenorrhea is a frequent condition affecting anorexic patients after stable weight recovery. It has been proposed that it could be due to alterations of the hypothalamic-pituitary-gonadal axis linked with persistent hormonal impairments, such as relative hypercortisolemia and hypoleptinemia, and psychological symptoms related to anorexia nervosa (AN). The aim of our study was to evaluate the metabolic and hormonal pattern involved in the persistence of amenorrhea after recovery from AN. Eight weight-recovered anorexic patients with amenorrhea were investigated and matched with 10 healthy eumenorrhoic women, comparable for age and BMI...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27907849/association-between-dehydroepiandrosterone-sulfate-and-attention-in-long-term-survivors-of-childhood-acute-lymphoblastic-leukemia-treated-with-only-chemotherapy
#3
Yin Ting Cheung, Wassim Chemaitilly, Daniel A Mulrooney, Tara M Brinkman, Wei Liu, Pia Banerjee, Deokumar Srivastava, Ching-Hon Pui, Leslie L Robison, Melissa M Hudson, Kevin R Krull
Long-term survivors of childhood acute lymphoblastic leukemia (ALL) are at risk for neurocognitive impairment, as well as compromised hypothalamic-pituitary-adrenal (HPA) function. Dehydroepiandrosterone-sulfate (DHEAS) is an adrenal androgen commonly used as a marker of HPA function. In the general population, a low level of DHEAS has been associated with poorer cognition. At ≥2years post-treatment, we examined the association of DHEAS with attention outcomes in 35 male and 34 female long-term survivors of childhood ALL (mean[standard deviation] age at evaluation 14...
November 16, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27901631/11-oxygenated-c19-steroids-are-the-predominant-androgens-in-polycystic-ovary-syndrome
#4
Michael W O'Reilly, Punith Kempegowda, Carl Jenkinson, Angela E Taylor, Jonathan L Quanson, Karl-Heinz Storbeck, Wiebke Arlt
CONTEXT: Androgen excess is a defining feature of polycystic ovary syndrome (PCOS) but the exact origin of hyperandrogenemia remains a matter of debate. Recent studies have highlighted the importance of the 11-oxygenated C19 steroid pathway to androgen metabolism in humans. In this study, we analyzed the contribution of 11-oxygenated androgens to the androgen excess phenotype in women with PCOS. METHODS: 114 women with PCOS and 49 healthy controls underwent measurement of serum androgens by liquid chromatography-tandem mass spectrometry...
November 30, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27898988/lipid-accumulation-product-lap-as-an-index-of-metabolic-and-hormonal-disorders-in-aging-men
#5
I Rotter, A Rył, A Szylińska, W Pawlukowska, A Lubkowska, M Laszczyńska
Lipid accumulation product (LAP) is an index used for evaluating lipid overaccumulation in adults. Our study aimed at assessing associations between LAP and metabolic syndrome (MetS) and its components, age-related testosterone deficiency syndrome (TDS), low-density cholesterol (LDL), as well as HOMA-IR (insulin resistance ratio), insulin level in non-diabetics and total testosterone (TT), estradiol E2, dehydroepiandrosterone sulphate (DHEAs) and sex hormone-binding globulin (SHBG) in aging men.313 men aged 50-75 were surveyed with regard to the prevalence of diabetes (T2DM) and hypertension (HT)...
November 29, 2016: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/27891401/premature-ovarian-failure-an-association-with-autoimmune-diseases
#6
Ayesha, Vandana Jha, Deepti Goswami
INTRODUCTION: Premature Ovarian Failure (POF) is the cessation of ovarian function before the age of 40 years. POF is reported to be associated with autoimmune diseases in 20-30% of cases. AIM: Patients presenting with idiopathic POF were screened for the presence of autoimmune disorders. MATERIALS AND METHODS: Twenty patients with idiopathic POF were included in the study. Baseline investigation in all subjects included fasting serum FSH, LH, E2, progesterone, free T3, free T4, Thyroid-Stimulating Hormone (TSH) and Anti-Thyroperoxidase (anti-TPO) antibodies, testosterone and Dehydroepiandrosterone (DHEAS) levels...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27882049/different-effects-of-myoinositol-plus-folic-acid-versus-combined-oral-treatment-on-androgen-levels-in-pcos-women
#7
Ali Cenk Ozay, Ozlen Emekci Ozay, Recep Emre Okyay, Erkan Cagliyan, Tuncay Kume, Bulent Gulekli
Recently, myoinositol (myo-ins) and folic acid combination has gained an important role for treating Polycystic Ovary Syndrome (PCOS), in addition to combined oral contraceptives (COC). We aimed to examine myo-ins effects on anti-Mullerian hormone (AMH) levels and compare them with those ones obtained administering COC. In this prospective study, 137 PCOS patients, diagnosed according to Rotterdam criteria and admitted to the Reproductive Endocrinology and Infertility Outpatient Clinic at Dokuz Eylul University (Izmir, Turkey), were included...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27875388/is-vulvovaginal-atrophy-due-to-a-lack-of-both-estrogens-and-androgens
#8
Fernand Labrie, Céline Martel, Georges Pelletier
OBJECTIVE: The aim of this study was to review the preclinical data showing the role of both estrogens and androgens in the physiology of the vagina, and, most likely, in vulvovaginal atrophy of menopause. METHODS: Mass spectrometry-based assays (validated according to the FDA guidelines) for the measurement of sex steroids, their precursors, and metabolites were used. In addition to fixation of the vagina for morphological examination, histomorphometry, immunocytochemistry, immunofluorescence, and quantitative reverse transcription polymerase chain reaction were performed...
November 21, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27871979/sex-specific-effects-of-dehydroepiandrosterone-dhea-on-glucose-metabolism-in-the-cns
#9
Claudia Vieira-Marques, Bruno Dutra Arbo, Aline Gonçalves Cozer, Ana Lúcia Hoefel, Ana Lúcia Cecconello, Priscila Zanini, Gabriela Niches, Luiz Carlos Kucharski, Maria Flávia M Ribeiro
DHEA is a neuroactive steroid, due to its modulatory actions on the central nervous system (CNS). DHEA is able to regulate neurogenesis, neurotransmitter receptors and neuronal excitability, function, survival and metabolism. The levels of DHEA decrease gradually with advancing age, and this decline has been associated with age related neuronal dysfunction and degeneration, suggesting a neuroprotective effect of endogenous DHEA. There are significant sex differences in the pathophysiology, epidemiology and clinical manifestations of many neurological diseases...
November 18, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27871978/differences-in-testosterone-and-its-precursors-by-sex-of-the-offspring-in-meconium
#10
Alexander J Frey, Bo Y Park, Emily R Schriver, Daniel R Feldman, Samuel Parry, Lisa A Croen, Daniele M Fallin, Irva Hertz-Picciotto, Craig J Newschaffer, Nathaniel W Snyder
Prenatal metabolism exerts profound effects on development. The first stool of the newborn, meconium, provides a window into the prenatal metabolic environment. The objective of this study was to examine the feasibility of meconium as a novel matrix to quantify prenatal steroid levels. We quantified parameters of analytical interest regarding the use of meconium, including sample stability. We hypothesized that meconium steroid content would differ by sex, prompting analysis of meconium to test effects of prenatal steroid metabolism...
November 18, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27871080/the-association-between-premature-adrenarche-and-cardiovascular-risk-may-be-greater-than-expected
#11
Nurullah Çelik, Hayrullah Alp, Emine Çamtosun, Esma Alp, Sibel Çelik, Erhan Berk
AIM: The aim of this study was to investigate the cardiovascular risk of children with premature adrenarche (PA). METHODS: A total of 75 children (44 with PA and 31 control subjects) aged 6-10 years were included in the study. Their metabolic, anthropometric, and echocardiographic parameters were recorded and compared. RESULTS: Triglyceride, DHEA-SO4, and 17-hydroxyprogesterone levels were significantly higher in the PA group (p = 0.04, p = 0...
November 22, 2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27867884/comparison-clinical-and-metabolic-effects-of-metformin-and-pioglitazone-in-polycystic-ovary-syndrome
#12
Karoon Shahebrahimi, Nasrin Jalilian, Nasrin Bazgir, Mansour Rezaei
INTRODUCTION: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women. PCOS comprises a broad spectrum of anomalies, including hyperandrogenism, chronic anovulation, obesity, and infertility. Insulin resistance and its compensatory hyperinsulinemia play a key role in the pathogenicity of PCOS. This study compares the effects of 2 types of insulin sensitizer drugs, metformin and pioglitazone, on clinical, metabolic, and endocrine characteristics of women with PCOS...
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27865406/an-adverse-immune-endocrine-profile-in-patients-with-tuberculosis-and-type-2-diabetes
#13
R Fernández, A Díaz, L D'Attilio, B Bongiovanni, N Santucci, D Bertola, H Besedovsky, A Del Rey, M L Bay, O Bottasso
Diabetes is a risk factor for the development of pulmonary tuberculosis (TB) and both diseases present endocrine alterations likely to play a role in certain immuno-endocrine-metabolic associated disorders. Patients with TB, or with TB and type 2 diabetes (TB + T2DM) and healthy controls (HCo) were assessed for plasma levels of cortisol, dehydroepiandrosterone (DHEA), estradiol, testosterone, growth hormone (GH), prolactin, insulin-like growth factor-1 (IGF-1), cytokines (IL-6, IL-10, IFN-γ) and the specific lymphoproliferative capacity of peripheral blood mononuclear cells...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27855510/uhplc-ms-ms-bioanalysis-of-urinary-dhea-cortisone-and-their-hydroxylated-metabolites-as-potential-biomarkers-for-cyp3a-mediated-drug-drug-interactions
#14
Naiyu Zheng, Lisa J Christopher, Xuewen Ma, Qin C Ji, Adela Buzescu, Hamza Kandoussi, Samira M Garonzik, Frank LaCreta, Anne-Francoise Aubry, Mark E Arnold, Jianing Zeng
AIM: A UHPLC-MS/MS assay was developed to quantify urinary dehydroepiandrosterone (DHEA), 7β-hydroxy-DHEA, cortisone and 6β-hydroxycortisone as potential biomarkers to predict CYP3A activity. RESULTS: A sensitive assay at LLOQ of 0.500 ng/ml with good accuracy and precision was developed for the four analytes in human urine. This UHPLC-MS/MS assay was optimized by eliminating nonspecific loss of the analytes in urine, ensuring complete hydrolysis of the conjugates to unconjugated forms and use of the product ions of [M+H-H2O](+) for multiple reaction monitoring detection of DHEA and 7β-hydroxy-DHEA...
December 2016: Bioanalysis
https://www.readbyqxmd.com/read/27853073/feminizing-adrenocortical-carcinoma-with-distinct-histopathological-findings
#15
Masako Hatano, Yasuhiro Takenaka, Ikuo Inoue, Keiko Homma, Tomonobu Hasegawa, Hisanobu Sasano, Takuya Awata, Shigehiro Katayama
We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor with heterogeneous intensity. Iodine-131 adosterol scintigraphy showed an increased uptake at the same site. Because feminizing adrenocortical carcinoma was suspected, right adrenalectomy was performed; the pathological diagnosis was adrenocortical carcinoma...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27845856/modified-release-and-conventional-glucocorticoids-and-diurnal-androgen-excretion-in-congenital-adrenal-hyperplasia
#16
Christopher M Jones, Ashwini Mallappa, Nicole Reisch, Nikolaos Nikolaou, Nils Krone, Beverly A Hughes, Donna M O'Neil, Martin J Whitaker, Jeremy W Tomlinson, Karl-Heinz Storbeck, Deborah P Merke, Richard J Ross, Wiebke Arlt
CONTEXT: The classic androgen synthesis pathway proceeds via DHEA, androstenedione and testosterone to 5α-dihydrotestosterone (DHT). However, DHT synthesis can also be achieved by an alternative pathway originating from 17α-hydroxyprogesterone (17OHP), which accumulates in congenital adrenal hyperplasia (CAH). Similarly, recent work has highlighted androstenedione-derived 11-oxygenated 19-carbon steroids as active androgens and, in CAH, androstenedione is generated directly from 17OHP...
November 15, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27832095/increased-muscular-5%C3%AE-dihydrotestosterone-in-response-to-resistance-training-relates-to-skeletal-muscle-mass-and-glucose-metabolism-in-type-2-diabetic-rats
#17
Naoki Horii, Koji Sato, Noboru Mesaki, Motoyuki Iemitsu
Regular resistance exercise induces skeletal muscle hypertrophy and improvement of glycemic control in type 2 diabetes patients. Administration of dehydroepiandrosterone (DHEA), a sex steroid hormone precursor, increases 5α-dihydrotestosterone (DHT) synthesis and is associated with improvements in fasting blood glucose level and skeletal muscle hypertrophy. Therefore, the aim of this study was to investigate whether increase in muscle DHT levels, induced by chronic resistance exercise, can contribute to skeletal muscle hypertrophy and concomitant improvement of muscular glucose metabolism in type 2 diabetic rats...
2016: PloS One
https://www.readbyqxmd.com/read/27809877/n-docosahexaenoylethanolamine-ameliorates-lps-induced-neuroinflammation-via-camp-pka-dependent-signaling
#18
Taeyeop Park, Huazhen Chen, Karl Kevala, Ji-Won Lee, Hee-Yong Kim
BACKGROUND: Brain inflammation has been implicated as a critical mechanism responsible for the progression of neurodegeneration and characterized by glial cell activation accompanied by production of inflammation-related cytokines and chemokines. Growing evidence also suggests that metabolites derived from docosahexaenoic acid (DHA) have anti-inflammatory and pro-resolving effects; however, the possible role of N-docosahexaenoylethanolamine (synaptamide), an endogenous neurogenic and synaptogenic metabolite of DHA, in inflammation, is largely unknown...
November 4, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27809697/determination-of-17ohpreg-and-dheas-by-lcmsms-impact-of-age-sex-pubertal-stage-and-bmi-on-the-%C3%AE-5-steroid-pathway
#19
Alexandra Elisabeth Kulle, Thomas Reinehr, Gunter Simic-Schleicher, Nadine C Hornig, Paul-Martin Holterhus
BACKGROUND: Dehydroepiandrosterone-sulfate (DHEAS) and 17-hydroxypregnenolone (17OHPreg) are important for understanding the Δ5-pathway, e.g. in adrenarche and obesity. While mass spectrometry has become the state-of-the-art method for quantifying steroids, there are few comprehensive age-, sex- and pubertal stage-specific reference ranges for children. AIMS: To develop a sensitive and reliable UPLC-MS/MS method for simultaneous quantification of DHEAS and 17OHPreg, and establish the entire age-, sex- and pubertal stage-specific reference ranges in children...
November 3, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27808591/the-impact-of-gastric-bypass-surgery-on-sex-hormones-and-menstrual-cycles-in-premenopausal-women
#20
Mette Mandrup Kjær, Sten Madsbad, David M Hougaard, Arieh S Cohen, Lisbeth Nilas
Obesity has adverse effects on ovulation, menstrual cyclicity and oocyte development leading to clinical symptoms such as infertility and menstrual disorders. The Roux-en-Y gastric bypass (RYGB) leads to weight loss, improved insulin sensitivity and may improve ovarian function. In 31 premenopausal women, 18 eu- and 13 oligo-/amenorrhoic, we followed the changes in follicular phase sex hormones 3, 6 and 12 month after RYGB. The average weight loss during the first postoperative year was 39.6 kg. The insulin sensitivity and serum insulin improved markedly especially within the first three postoperative months...
November 3, 2016: Gynecological Endocrinology
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