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https://www.readbyqxmd.com/read/29765575/association-of-serum-testosterone-and-dehydroepiandrosterone-sulfate-with-rheumatoid-arthritis-a-case-control-study
#1
Mahin Lashkari, Akram Noori, Sonia Oveisi, Mohammadreza Kheirkhah
Background: It is supposed that hypoandrogenism may be involved in the pathogenesis of rheumatoid arthritis (RA). Testosterone and dehydroepiandrosterone sulfate (DHEAs) levels decrease in body fluids of patients with RA. Objective: The aim of this study was to determine the association of serum testosterone and DHEAs with RA. Methods: This case-control study was conducted on 59 patients with RA and 61 healthy gender- and age-matched controls at Qazvin University of Medical Sciences, Qazvin, Iran, in 2014...
March 2018: Electronic Physician
https://www.readbyqxmd.com/read/29759075/metabolic-profiles-in-community-acquired-pneumonia-developing-assessment-tools-for-disease-severity
#2
Pu Ning, Yali Zheng, Qiongzhen Luo, Xiaohui Liu, Yu Kang, Yan Zhang, Rongbao Zhang, Yu Xu, Donghong Yang, Wen Xi, Keqiang Wang, Yusheng Chen, Shuchang An, Zhancheng Gao
BACKGROUND: This study aimed to determine whether community-acquired pneumonia (CAP) had a metabolic profile and whether this profile can be used for disease severity assessment. METHODS: A total of 175 individuals including 119 CAP patients and 56 controls were enrolled and divided into two cohorts. Serum samples from a discovery cohort (n = 102, including 38 non-severe CAP, 30 severe CAP, and 34 age and sex-matched controls) were determined by untargeted ultra-high-performance liquid chromatography with tandem mass spectrometry (LC-MS/MS)-based metabolomics...
May 14, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29757399/associations-of-dehydroepiandrosterone-sulfate-with-cardiometabolic-risk-factors-in-prepubertal-children
#3
Aino Mäntyselkä, Virpi Lindi, Anna Viitasalo, Aino-Maija Eloranta, Jyrki Ågren, Sari Väisänen, Raimo Voutilainen, Tomi Laitinen, Timo A Lakka, Jarmo Jääskeläinen
Context: Premature adrenarche (PA) has been associated with overweight and insulin resistance, but the associations of serum dehydroepiandrosterone sulfate (DHEAS) concentration with other cardiometabolic risk factors are uncertain. Objective: To examine the associations of serum DHEAS concentration with several cardiometabolic risk factors in children. Design: Cross-sectional data from the Physical Activity and Nutrition in Children Study...
May 10, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29753319/biotransformation-of-steroids-by-entomopathogenic-strains-of-isaria-farinosa
#4
Ewa Kozłowska, Natalia Hoc, Jordan Sycz, Monika Urbaniak, Monika Dymarska, Jakub Grzeszczuk, Edyta Kostrzewa-Susłow, Łukasz Stępień, Elżbieta Pląskowska, Tomasz Janeczko
BACKGROUND: Steroid compounds are very interesting substrates for biotransformation due to their high biological activity and a high number of inactivated carbons which make chemical modification difficult. Microbial transformation can involve reactions which are complicated and uneconomical in chemical synthesis, and searching for a new effective biocatalyst is necessary. The best known entomopathogenic species used in steroid modification is Beauveria bassiana. In this study we tested the ability of Isaria farinosa, another entomopathogenic species, to transform several steroids...
May 12, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29753148/sex-related-differences-in-the-associations-between-maternal-dioxin-like-compounds-and-reproductive-and-steroid-hormones-in-cord-blood-the-hokkaido-study
#5
Chihiro Miyashita, Atsuko Araki, Takahiko Mitsui, Sachiko Itoh, Houman Goudarzi, Seiko Sasaki, Jumboku Kajiwara, Tsuguhide Hori, Kazutoshi Cho, Kimihiko Moriya, Nobuo Shinohara, Katsuya Nonomura, Reiko Kishi
BACKGROUND: Prenatal exposure to dioxin-like compounds (DLCs) irreversibly affects fetal reproductive and steroid hormone synthesis. OBJECTIVE: This study aimed to assess the relationships between maternal DLCs and cord blood reproductive and steroid hormones. METHODS: Participants in this study were pregnant women who enrolled in the Sapporo Cohort of the Hokkaido Study between 2002 and 2005. We quantified 29 DLCs during the 2nd and 3rd trimesters in maternal blood...
May 9, 2018: Environment International
https://www.readbyqxmd.com/read/29746855/the-first-multi-zoo-application-of-an-allostatic-load-index-to-western-lowland-gorillas-gorilla-gorilla-gorilla
#6
Ashley N Edes, Barbara A Wolfe, Douglas E Crews
Vertebrate stress responses are highly adaptive biological functions, maximizing survival probability in life-threatening situations. However, experiencing repeated and/or chronic stressors can generate physiological dysregulation and lead to disease. Because stress responses are multi-systemic and involve a wide range of physiological functions, identifying responses to stressors is best accomplished using integrated biomarker models. Allostatic load, defined as the physiological dysregulation that accumulates over the lifespan due to stressful experiences, is one such model...
May 7, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29743556/no-evidence-for-the-immunocompetence-handicap-hypothesis-in-male-humans
#7
Judyta Nowak, Bogusław Pawłowski, Barbara Borkowska, Daria Augustyniak, Zuzanna Drulis-Kawa
The observations that testosterone might be immunosuppressive, form the basis for the immunocompetence handicap hypothesis (ICHH). According to ICHH only high-quality individuals can maintain high levels of testosterone and afford the physiological cost of hormone-derived immunosuppression. The animal and human studies that attempted to support the ICHH by precisely defined impairment of immunity associated with high testosterone levels are inconclusive. Furthermore, human studies have used only selected immune functions and varying testosterone fractions...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29743239/human-dhea-sulfation-requires-direct-interaction-between-paps-synthase-2-and-dhea-sulfotransferase-sult2a1
#8
Jonathan W Mueller, Jan Idkowiak, Tarsis F Gesteira, Cecilia Vallet, Rebecca Hardman, Johannes van den Boom, Vivek Dhir, Shirley K Knauer, Edina Rosta, Wiebke Arlt
The high-energy sulfate donor 3'-phosphoadenosine-5'-phosphosulfate (PAPS), generated by human PAPS synthase isoforms PAPSS1 and PAPSS2, is required for all human sulfation pathways. Sulfotransferase SULT2A1 uses PAPS for sulfation of the androgen precursor dehydroepiandrosterone (DHEA), thereby reducing downstream activation of DHEA to active androgens. Human PAPSS2 mutations manifest with undetectable DHEA sulfate, androgen excess and metabolic disease, suggesting that ubiquitous PAPSS1 cannot compensate for deficient PAPSS2 in supporting DHEA sulfation...
May 9, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29739821/c-type-natriuretic-peptide-a-link-between-hyperandrogenism-and-anovulation-in-a-mouse-model-of-polycystic-ovary-syndrome
#9
Adelina M Reis, Kinulpe Honorato-Sampaio
The polycystic ovary (PCO) syndrome (PCOS) is the most common cause of anovulatory infertility in women and is associated with several clinical disorders. Despite the great amount of research in the area, mechanisms involved in the genesis of this syndrome remain poorly understood. In a recent issue of Clinical Science (vol. 132, issue 7, 759-776), Wang and colleagues, highlight the important role of overactivated C-type natriuretic peptide (CNP) and natriuretic peptide receptor 2 (CNP/NPR2) system in preventing oocyte maturation and ovulation in PCOS mice model induced by androgen...
May 16, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29725371/analyses-of-risk-factors-for-polycystic-ovary-syndrome-complicated-with-non-alcoholic-fatty-liver-disease
#10
Jianhai Zhang, Jian Hu, Chunxia Zhang, Yanni Jiao, Xiang Kong, Wei Wang
The risk factors related to polycystic ovary syndrome (PCOS) patients complicated with non-alcoholic fatty liver disease (NAFLD) were investigated. A total of 188 PCOS patients treated in Shengli Oilfield Central Hospital (Dongying, China) from February 2014 to February 2015 were retrospectively analyzed as PCOS group, and PCOS group was further divided into NAFLD group and non-NAFLD (N-NAFLD) group according to the liver B ultrasound. In the same time-period, 65 healthy people were selected as normal control group...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29725246/dehydroepiandrosterone-supplementation-combined-with-weight-loading-whole-body-vibration-training-wwbv-affects-exercise-performance-and-muscle-glycogen-storage-in-middle-aged-c57bl-6-mice
#11
Yi-Ming Chen, Hao-Chieh Lee, Mu-Tsung Chen, Chi-Chang Huang, Wen-Chyuan Chen
Background : Adequate nutritional intake and an optimal training program are important elements of any strategy to preserve or increase muscle mass and strength during aging. Purpose : In the current study, we investigate the effects of Dehydroepiandrosterone (DHEA), one of the most abundant circulating steroids in humans and a precursor hormone, supplementation combined with a weight-loading whole-body vibration (WWBV) on exercise performance, physical fatigue-related biochemical responses and testosterone content in middle-aged 9 months old C57BL/6 mice...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29723293/elevated-androstenedione-in-young-adult-but-not-early-adolescent-prenatally-androgenized-female-rats
#12
Ami B Shah, Isaac Nivar, Diana L Speelman
BACKGROUND: Elevated testosterone (T) is routinely reported as a marker of hyperandrogenemia in rodent models for polycystic ovary syndrome (PCOS). In women with PCOS, elevated serum androstenedione (A4) is associated with more severe phenotypes, including a positive correlation with serum T, DHEAS, free androgen index (FAI), LH, and LH/FSH ratio. Furthermore, A4, along with calculated free T and FAI, was identified as one of the best predictors of PCOS in adult women of all ages (18 to > 50 y)...
2018: PloS One
https://www.readbyqxmd.com/read/29713278/dehydroepiandrosterone-antagonizes-pain-stress-induced-suppression-of-testosterone-production-in-male-rats
#13
Qiqi Zhu, Fei Ge, Xiaoheng Li, Hou-Sheng Deng, Miao Xu, Tiao Bu, Jingyang Li, Yiyan Wang, Yuanyuan Shan, Ren-Shan Ge, Ming Yao
Background: Leydig cells secrete the steroid hormone, testosterone, which is essential for male fertility and reproductive health. Stress increases the secretion of glucocorticoid [corticosterone, (CORT) in rats] that decreases circulating testosterone levels in part through a direct action on its receptors in Leydig cells. Intratesticular CORT level is dependent on oxidative inactivation of CORT by 11β-hydroxysteroid dehydrogenase 1 (HSD11B1) in rat Leydig cells. Pain may cause the stress, thus affecting testosterone production in Leydig cells...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29710837/mechanism-of-the-dual-activities-of-human-cyp17a1-and-binding-to-anti-prostate-cancer-drug-abiraterone-revealed-by-a-novel-v366m-mutation-causing-17-20-lyase-deficiency
#14
Mónica Fernández-Cancio, Núria Camats, Christa E Flück, Adam Zalewski, Bernhard Dick, Brigitte M Frey, Raquel Monné, Núria Torán, Laura Audí, Amit V Pandey
The CYP17A1 gene regulates sex steroid biosynthesis in humans through 17α-hydroxylase/17,20 lyase activities and is a target of anti-prostate cancer drug abiraterone. In a 46, XY patient with female external genitalia, together with a loss of function mutation S441P, we identified a novel missense mutation V366M at the catalytic center of CYP17A1 which preferentially impaired 17,20 lyase activity. Kinetic experiments with bacterially expressed proteins revealed that V366M mutant enzyme can bind and metabolize pregnenolone to 17OH-pregnenolone, but 17OH-pregnenolone binding and conversion to dehydroepiandrosterone (DHEA) was impaired, explaining the patient’s steroid profile...
April 29, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29703963/determination-of-dehydroepiandrosterone-and-its-biologically-active-oxygenated-metabolites-in-human-plasma-evinces-a-hormonal-imbalance-during-hiv-tb-coinfection
#15
María Belén Vecchione, Javier Eiras, Guadalupe Verónica Suarez, Matías Tomás Angerami, Cecilia Marquez, Omar Sued, Graciela Ben, Héctor Miguel Pérez, Diego Gonzalez, Patricia Maidana, Viviana Mesch, María Florencia Quiroga, Andrea Claudia Bruttomesso
An estimated one third of the world's population is affected by latent tuberculosis (TB), which once active represents a leading cause of death among infectious diseases. Human immunodeficiency virus (HIV) infection is a main predisposing factor to TB reactivation. Individuals HIV-TB co-infected develop a chronic state of inflammation associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation. This results in a hormonal imbalance, disturbing the physiological levels of cortisol and dehydroepiandrosterone (DHEA)...
April 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29701669/differentiating-medicated-patients-suffering-from-major-depressive-disorder-from-healthy-controls-by-spot-urine-measurement-of-monoamines-and-steroid-hormones
#16
Chandra S Wijaya, Jovia J Z Lee, Syeda F Husain, Cyrus S H Ho, Roger S McIntyre, Wilson W Tam, Roger C M Ho
Introduction : Major Depressive Disorder (MDD) is a common psychiatric disorder. Currently, there is no objective, cost-effective and non-invasive method to measure biological markers related to the pathogenesis of MDD. Previous studies primarily focused on urinary metabolite markers which are not proximal to the pathogenesis of MDD. Herein, we compare urinary monoamines, steroid hormones and the derived ratios amongst MDD when compared to healthy controls. Methods : Morning urine samples of medicated patients suffering from MDD ( n = 47) and healthy controls ( n = 41) were collected...
April 26, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29695968/neurosteroid-transport-in-the-brain-role-of-abc-and-slc-transporters
#17
REVIEW
Markus Grube, Paul Hagen, Gabriele Jedlitschky
Neurosteroids, comprising pregnane, androstane, and sulfated steroids can alter neuronal excitability through interaction with ligand-gated ion channels and other receptors and have therefore a therapeutic potential in several brain disorders. They can be formed in brain cells or are synthesized by an endocrine gland and reach the brain by penetrating the blood-brain barrier (BBB). Especially sulfated steroids such as pregnenolone sulfate (PregS) and dehydroepiandrosterone sulfate (DHEAS) depend on transporter proteins to cross membranes...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29694639/assessing-endocrine-and-immune-parameters-in-human-immunodeficiency-virus-infected-patients-before-and-after-the-immune-reconstitution-inflammatory-syndrome
#18
Liliana Rateni, Sergio Lupo, Liliana Racca, Jorge Palazzi, Sergio Ghersevich
Objective The present study compares immune and endocrine parameters between HIV-infected patients who underwent the Immune Reconstitution Inflammatory Syndrome (IRIS-P) during antiretroviral therapy (ART) and HIV-patients who did not undergo the syndrome (non-IRIS-P). Materials and methods Blood samples were obtained from 31 HIV-infected patients (15 IRIS-P and 16 non-IRIS-P) before ART (BT) and 48 ± 2 weeks after treatment initiation (AT). Plasma Interleukin-6 (IL-6) and Interleukin-18 (IL-18) were determined by ELISA...
February 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29684479/impairment-of-the-gn%C3%AE-11-controlled-expression-of-claudin-1-and-mmp-9-and-collective-migration-of-human-breast-cancer-mcf-7-cells-by-dheas
#19
Neha Upmanyu, Ahmed Bulldan, Dimitrios Papadopoulos, Raimund Dietze, Viveka Nand Malviya, Georgios Scheiner-Bobis
Although dehydroepiandrosterone sulfate (DHEAS) constitutes the most abundant steroid in humans, in-depth investigations of its effects are rather scarce. We address here DHEAS effects on the estrogen receptor-positive metastatic human breast cancer cell line MCF-7. We focus on DHEAS-mediated signaling that might influence expression of claudin-1 and matrix metalloproteinase-9 (MMP-9), both known to be critical factors for migration and invasiveness of various cancers, including breast cancer cells. Physiological concentrations of DHEAS trigger persistent phosphorylation of Erk1/2 in MCF-7 cells...
April 20, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29678582/reversion-of-aging-related-dheas-decline-in-mouse-plasma-alleviates-aging-related-glucose-tolerance-impairment-by-potentiation-of-glucose-stimulated-insulin-secretion-of-acute-phase
#20
Junlei Ma, Jiang Yue, Rong Huang, Yu Liao, Shengxian Li, Wei Liu
AIMS/HYPOTHESIS: The latest research proposes mild age-related diabetes (MARD) as a subgroup of type 2 diabetes. While in human circulating dehydroepiandrosterone sulfate (DHEAS) decline with age is related to MARD, the role of circulating DHEAS in insulin secretion remains little known. METHODS: After intraperitoneal administration of glucose (2 g/kg) together with DHEAS (50 μg/kg) or equivalent DMSO to young (6-8 week old) or aging (12 month old) male C57BL/6 mice, plasma DHEAS and blood glucose were measured at indicated time point...
April 17, 2018: Biochemical and Biophysical Research Communications
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