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https://www.readbyqxmd.com/read/28924479/marked-hyperandrogenicity-in-a-60-year-old-woman
#1
Khaled Aljenaee, Sulaiman Ali, Seong Keat Cheah, Owen MacEneaney, Niall Mulligan, Neil Hickey, Tommy Kyaw Tun, Seamus Sreenan, John H McDermott
Markedly elevated androgen levels can lead to clinical virilization in females. Clinical features of virilization in a female patient, in association with biochemical hyperandrogenism, should prompt a search for an androgen-producing tumor, especially of ovarian or adrenal origin. We herein report the case of a 60-year-old woman of Pakistani origin who presented with the incidental finding of male pattern baldness and hirsutism. Her serum testosterone level was markedly elevated at 21 nmol/L (normal range: 0...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28921241/evaluating-the-efficacy-of-vaginal-dehydroepiandosterone-for-vaginal-symptoms-in-postmenopausal-cancer-survivors-ncctg-n10c1-alliance
#2
Debra L Barton, Jeff A Sloan, Lynne T Shuster, Paula Gill, Patricia Griffin, Kathleen Flynn, Shelby A Terstriep, Fauzia N Rana, Travis Dockter, Pamela J Atherton, Michaela Tsai, Keren Sturtz, Jacqueline M Lafky, Mike Riepl, Jacqueline Thielen, Charles L Loprinzi
BACKGROUND: Women with estrogen deficiencies can suffer from vaginal symptoms that negatively impact sexual health. This study evaluated vaginal dehydroepiandrosterone (DHEA) for alleviation of vaginal symptoms. METHODS: This three-arm randomized, controlled trial evaluated DHEA 3.25 mg and DHEA 6.5 mg, each compared to a plain moisturizer (PM) over 12 weeks, to improve the severity of vaginal dryness or dyspareunia, measured with an ordinal scale, and overall sexual health using the Female Sexual Function Index (FSFI)...
September 18, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28919553/social-evaluative-threat-with-verbal-performance-feedback-alters-neuroendocrine-response-to-stress
#3
Jenny M Phan, Ekaterina Schneider, Jeremy Peres, Olga Miocevic, Vanessa Meyer, Elizabeth A Shirtcliff
Laboratory stress tasks such as the Trier Social Stress Test (TSST) have provided a key piece to the puzzle for how psychosocial stress impacts the hypothalamic-pituitary-adrenal axis, other stress-responsive biomarkers, and ultimately wellbeing. These tasks are thought to work through biopsychosocial processes, specifically social evaluative threat and the uncontrollability heighten situational demands. The present study integrated an experimental modification to the design of the TSST to probe whether additional social evaluative threat, via negative verbal feedback about speech performance, can further alter stress reactivity in 63 men and women...
September 15, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28912337/adrenal-hyperandrogenism-does-not-deteriorate-insulin-resistance-and-lipid-profile-in-women-with-pcos
#4
Stavroula A Paschou, Eleni Palioura, Dimitrios Ioannidis, Panagiotis Anagnostis, Argyro Panagiotakou, Vasiliki Loi, Georgios Karageorgos, Dimitrios Goulis, Andromachi Vryonidou
OBJECTIVE: The aim of this study was to investigate the impact of adrenal hyperandrogenism on insulin resistance and lipid profile in women with PCOS. PATIENTS AND METHODS: We studied 372 women with PCOS according to the NIH criteria. 232 age and BMI-matched women served as controls in order to define adrenal hyperandrogenism (DHEA-S >95th percentile). Then, patients with PCOS were classified into two groups, with adrenal hyperandrogenism (PCOS-AH, n=108) and without adrenal hyperandrogenism (PCOS-NAH, n=264)...
September 14, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28911133/kisspeptin-is-a-novel-regulator-of-human-fetal-adrenocortical-development-and-function-a-finding-with-important-implications-for-the-human-fetoplacental-unit
#5
Harshini Katugampola, Peter J King, Sumana Chatterjee, Muriel Meso, Andrew J Duncan, John C Achermann, Leo Guasti, Lea Ghataore, Norman F Taylor, Rebecca Allen, Shemoon Marlene, Joseph Aquilina, Ali Abbara, Channa N Jaysena, Waljit S Dhillo, Leo Dunkel, Ulla Sankilampi, Helen L Storr
Context: The human fetal adrenal (HFA) is an integral component of the fetoplacental unit and important for the maintenance of pregnancy. Low kisspeptin levels during pregnancy are associated with miscarriage, and kisspeptin and its receptor are expressed in the HFA. However, the role of kisspeptin in fetal adrenal function remains unknown. Objective: To determine the role of kisspeptin in the developing HFA. Design: Experiments using H295R and primary HFA cells as in vitro models of the fetal adrenal...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28903889/gdf9-and-bmp15-expressions-and-fine-structure-changes-during-folliculogenesis-in-polycystic-ovary-syndrome
#6
Meryem İlkay Karagül, Savaş Aktaş, Banu Coşkun Yılmaz, Mustafa Yılmaz, Gülhan Örekiçi Temel
BACKGROUND: Polycystic Ovary Syndrome (PCOS) is the most frequently seen endocrine disorder in women of the reproductive age with the prevalence of about 10%. AIMS: To investigate the efficiency of the growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) during folliculogenesis in a dehydroepiandrosterone (DHEA)-induced mouse PCOS model. STUDY DESIGN: Animal experimentation. METHODS: Mice were divided into three groups; control, vehicle and PCOS group...
September 13, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28903616/circulating-dehydroepiandrosterone-sulphate-decreases-even-with-a-slight-change-in-oestradiol
#7
Sumika Matsui, Toshiyuki Yasui, Kana Kasai, Kanako Yoshida, Takeshi Kato, Hirokazu Uemura, Akira Kuwahara, Toshiya Matsuzaki, Minoru Irahara
The aim of this study was to determine the effect of hormone replacement therapy (HRT) on changes in circulating dehydroepiandrosterone-sulphate (DHEA-S) with focus on the relationship between oestrogen level and change in DHEA-S. Forty-two women were enrolled in this longitudinal study. Nineteen women received oral oestradiol and twenty-three women received transdermal oestradiol continuously. Twenty women received progesterone continuously except for women who had undergone hysterectomy. Circulating oestradiol, follicle-stimulating hormone, luteinising hormone and DHEA-S levels before and at 3 months after commencement of HRT were measured...
September 14, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28894299/dhea-inhibits-acute-microglia-mediated-inflammation-through-activation-of-the-trka-akt1-2-creb-jmjd3-pathway
#8
V I Alexaki, G Fodelianaki, A Neuwirth, C Mund, A Kourgiantaki, E Ieronimaki, K Lyroni, M Troullinaki, C Fujii, W Kanczkowski, A Ziogas, M Peitzsch, S Grossklaus, B Sönnichsen, A Gravanis, S R Bornstein, I Charalampopoulos, C Tsatsanis, T Chavakis
Dehydroepiandrosterone (DHEA) is the most abundant circulating steroid hormone in humans, produced by the adrenals, the gonads and the brain. DHEA was previously shown to bind to the nerve growth factor receptor, tropomyosin-related kinase A (TrkA), and to thereby exert neuroprotective effects. Here we show that DHEA reduces microglia-mediated inflammation in an acute lipopolysaccharide-induced neuro-inflammation model in mice and in cultured microglia in vitro. DHEA regulates microglial inflammatory responses through phosphorylation of TrkA and subsequent activation of a pathway involving Akt1/Akt2 and cAMP response element-binding protein...
September 12, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28893621/rare-genetic-variants-in-the-sodium-dependent-organic-anion-transporter-soat-slc10a6-effects-on-transport-function-and-membrane-expression
#9
Josefine Bennien, Thomas Fischer, Joachim Geyer
Sulfo-conjugated steroid hormones, such as dehydroepiandrosterone sulfate (DHEAS), pregnenolone sulfate or estrone-3-sulfate are abundant in the body, but are biologically inactive at classical androgen and estrogen steroid receptors. However, after carrier-mediated import and de-conjugation by the steroid sulfatase, these compounds participate in the overall steroid regulation of reproductive organs. The sodium-dependent organic anion transporter SOAT, coded by the SLC10A6 gene, is specific for the transport of steroid sulfates and is highly expressed in testicular germ cells, including pachytene spermatocytes, secondary spermatocytes, and round spermatids...
September 8, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28893591/neurosteroid-dehydroepiandrosterone-improves-active-avoidance-retrieval-and-induces-antidepressant-like-behavior-in-rats
#10
Janko Samardzic, Boris Hencic, Jasna Jancic, Dragana Jadzic, Milos Djuric, Dragan I Obradovic, Dubravka Svob Strac
Various studies reported beneficial effects of dehydroepiandrosterone (DHEA) and its sulphate (DHEAS), the neurosteroids involved in various brain functions, on synaptic plasticity, neuronal survival, memory, learning and behavior. This study aimed to investigate the behavioral profile of acute DHEA treatment by using active avoidance (AA) task, primarily predictive of the effects on the retrieval-based learning, and by applying forced swim test (FST), for assessment of antidepressant-like potential. Adult male Wistar rats received intraperitoneal injections of either DHEA (2, 10, 20mg/kg) or solvent, 30min prior to testing...
September 8, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28892223/dehydroepiandrosterone-as-a-potential-agent-to-slow-down-ovarian-aging
#11
Li-Te Lin, Jiin-Tsuey Cheng, Peng-Hui Wang, Chia-Jung Li, Kuan-Hao Tsui
AIM: Ovarian aging, which leads to diminished ovarian reserve and decreased oocyte quality, is highly associated with poor reproductive outcomes. It has been suggested that dehydroepiandrosterone (DHEA) might be able to temporarily slow down the aging process. This study attempted to investigate the clinical benefits of DHEA in older patients and the anti-senescence effect of DHEA on cumulus cells (CC) and human ovarian granulosa cells (HO23 cell line). METHODS: This prospective study enrolled 88 patients who underwent in vitro fertilization (IVF), including 30 younger patients (aged ≤ 37 years) and 58 older patients (aged > 37 years)...
September 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28891949/isaria-fumosorosea-kch-j2-entomopathogenic-strain-as-an-effective-biocatalyst-for-steroid-compound-transformations
#12
Ewa Kozłowska, Monika Dymarska, Edyta Kostrzewa-Susłow, Tomasz Janeczko
The catalytic activity of enzymes produced by an entomopathogenic filamentous fungus (Isaria fumosorosea KCh J2) towards selected steroid compounds (androstenedione, adrenosterone, progesterone, 17α-methyltestosterone and dehydroepiandrosterone) was investigated. All tested substrates were efficiently transformed. The structure of the substrate has a crucial impact on regio- and stereoselectivity of hydroxylation since it affects binding to the active site of the enzyme. Androstenedione was hydroxylated in the 7α-position to give a key intermediate in the synthesis of the diuretic-7α-hydroxyandrost-4-ene-3,17-dione with 82% conversion...
September 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28890388/dhea-prevents-ribavirin-induced-anemia-via-inhibition-of-glucose-6-phosphate-dehydrogenase
#13
Lynda Handala, Barbara Domange, Hakim Ouled-Haddou, Loïc Garçon, Eric Nguyen-Khac, Francois Helle, Sandra Bodeau, Gilles Duverlie, Etienne Brochot
Ribavirin has been widely used for antiviral therapy. Unfortunately, ribavirin-induced anemia is often a cause of limiting or interrupting treatment. Our team has observed that dehydroepiandrosterone (DHEA) has a protective effect against in vitro and in vivo ribavirin-induced hemolysis. The aim of this study was to better understand this effect as well as the underlying mechanism(s). DHEA was able to reduce in vitro intraerythrocytic ATP depletion induced by ribavirin. Only 1% of ATP remained after incubation with ribavirin (2 mM) at 37 °C for 24 h vs...
September 8, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28890368/cyp17a1-independent-production-of-the-neurosteroid-derived-5%C3%AE-pregnan-3%C3%AE-6%C3%AE-diol-20-one-in-androgen-responsive-prostate-cancer-cell-lines-under-serum-starvation-and-inhibition-by-abiraterone
#14
Antonio G Gomes de Mello Martins, Giuseppe Allegretta, Gerhard Unteregger, Jörg Haupenthal, Jens Eberhard, Michael Hoffmann, Jill A van der Zee, Kerstin Junker, Michael Stöckle, Rolf Müller, Rolf W Hartmann, Carsten-H Ohlmann
CYP17A1-independent intratumoral steroid hormone synthesis is regarded as one possible explanation for resistance to treatment with the CYP17-inhibitor Abiraterone (Abi). The aim of our study was therefore to investigate the steroid metabolism of prostate cancer cells under serum starvation and the effects of Abi treatment. We assessed steroid metabolism in a panel of prostate cancer cells under serum starvation by radioactivity detector-coupled HPLC and HPLC-ESI-ToF-mass spectrometry after treatment with pregnenolone, progesterone and allopregnanolone...
September 7, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28883857/postmenopausal-cognitive-changes-and-androgen-levels-in-the-context-of-apolipoprotein-e-polymorphism
#15
Iwona Bojar, Jarosław Pinkas, Mariusz Gujski, Alfred Owoc, Dorota Raczkiewicz, Kasia Gustaw-Rothenberg
INTRODUCTION: The focus of this study was to assess cognitive functions in relation to androgens and specifically testosterone and dehydroepiandrosterone in postmenopausal women as well as the correlation between cognitive functions and these two androgens according to polymorphism of the apolipoprotein E gene (APOE). MATERIAL AND METHODS: A group of 402 women was recruited to the study (minimum 2 years after the last menstruation, follicle-stimulating hormone (FSH) more than 30 U/ml and no dementia signs on Montreal Cognitive Assessment)...
August 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28878092/equine-fetal-adrenal-gonadal-and-placental-steroidogenesis
#16
Erin L Legacki, Barry A Ball, C Jo Corbin, Shavahn C Loux, Kirsten E Scoggin, Scott D Stanley, Alan J Conley
Equine fetuses have substantial circulating pregnenolone concentrations and thus have been postulated to provide significant substrate for placental 5α-reduced pregnane production, but the fetal site of pregnenolone synthesis remains unclear. The current studies investigated steroid concentrations in blood, adrenal glands, gonads and placenta from fetuses (4, 6, 9 and 10 months of gestational age (GA)), as well as tissue steroidogenic enzyme transcript levels. Pregnenolone and dehydroepiandrosterone (DHEA) were the most abundant steroids in fetal blood, pregnenolone was consistently higher but decreased progressively with GA...
October 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28875157/sex-hormones-and-quantitative-ultrasound-parameters-at-the-heel-in-men-and-women-from-the-general-population
#17
Konrad Pätzug, Nele Friedrich, Hanna Kische, Anke Hannemann, Henry Völzke, Matthias Nauck, Brian G Keevil, Robin Haring
PURPOSE/INTRODUCTION: The present study investigates potential associations between liquid chromatography-mass spectrometry (LC-MS) measured sex hormones, dehydroepiandrosterone sulphate, sex hormone-binding globulin (SHBG) and bone ultrasound parameters at the heel in men and women from the general population. METHODS: Data from 502 women and 425 men from the population-based Study of Health in Pomerania (SHIP-TREND) were used. Cross-sectional associations of sex hormones including testosterone (TT), calculated free testosterone (FT), dehydroepiandrosterone sulphate (DHEAS), androstenedione (ASD), estrone (E1) and SHBG with quantitative ultrasound (QUS) parameters at the heel, including broadband ultrasound attenuation (BUA), speed of sound (SOS) and stiffness index (SI) were examined by analysis of variance (ANOVA) and multivariable quantile regression models...
December 2017: Bone Reports
https://www.readbyqxmd.com/read/28867888/efficacy-of-combined-cabergoline-and-metformin-compared-to-metformin-alone-on-cycle-regularity-in-patients-with-polycystic-ovarian-disease-with-hyperprolactinemia-a-randomized-clinical-trial
#18
Mervat Ali Mohamed Elsersy
PURPOSE: Polycystic ovarian syndrome (PCOS) is a common reproductive disorder. Increasing serum prolactin in these patients could be detected in both follicular and luteal phase of the normal and stimulated cycles. Hyperprolactinemia affects the hypothalamic-pituitary-ovarian axis causing anovulation and abnormal uterine bleeding. In this study, the efficacy of combined cabergoline and metformin therapy was compared to metformin therapy alone in patients with PCOS on the body mass index, androgen profile and menstrual cycle regulation...
October 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28865040/the-impact-of-peri-operative-dexamethasone-administration-on-the-normal-hypothalamic-pituitary-adrenal-response-to-major-surgical-procedures
#19
Katia El-Sibai, Aman Rajpal, Ribal Al-Aridi, Warren R Selman, Baha M Arafah
BACKGROUND: Surgical procedures are associated with activation of the hypothalamic-pituitary-adrenal axis (HPA). Studies examining HPA dynamics peri-operatively are limited and the modulating influence of peri-operatively administered glucocorticoids on that is not well established. This investigation examined alterations in HPA function and the impact of dexamethasone (DEX) administration during the peri-operative period. METHODS: We examined HPA function in 297 patients with normal function who had surgical procedures including pituitary mass resection (n = 191), craniotomy (n = 17) and other thoracic/ abdominal/ pelvic surgeries (n = 89)...
September 1, 2017: Endocrine
https://www.readbyqxmd.com/read/28854691/the-clinical-recovery-of-tuberculosis-patients-undergoing-specific-treatment-is-associated-with-changes-in-the-immune-and-neuroendocrine-responses
#20
Ariana Díaz, Bettina Bongiovanni, Luciano D'Attilio, Natalia Santucci, Griselda Dídoli, Rocío Del Valle Fernández, Leandro Kovalevski, Susana Lioi, Walter Gardeñez, Nadia Brandan, Luis J Nannini, Hugo Besedovsky, Adriana Del Rey, Oscar Bottasso, María Luisa Bay
Tuberculosis (TB) caused by Mycobacterium tuberculosis is a health problem worldwide. Patients with pulmonary TB show a neuro-immune-endocrine imbalance characterized by an impaired cellular immunity together with increased plasma levels of cortisol, pro- and anti-inflammatory cytokines and markedly decreased dehydroepiandrosterone (DHEA) levels. Extending these findings, we now investigated the immune-endocrine profile of TB patients undergoing specific treatment. Patients (n = 24) were bled at diagnosis (T0), 2, 4, 6 months after treatment initiation and 3 months following its completion...
September 29, 2017: Pathogens and Disease
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