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https://www.readbyqxmd.com/read/28815018/serum-complexed-and-free-prostate-specific-antigen-levels-are-lower-in-female-elite-athletes-in-comparison-to-control-women
#1
Emma Eklund, Eleftherios P Diamandis, Carla Muytjens, Sarah Wheeler, Anu Mathew, Martin Stengelin, Eli Glezer, Galina Nikolenko, Marshall D Brown, Yingye Zheng, Angelica Lindén Hirschberg
BACKGROUND: We hypothesize that prostate specific antigen (PSA), a protein that it is under regulation by androgens, may be differentially expressed in female elite athletes in comparison to control women. METHODS: We conducted a cross-sectional study of 106 female athletes and 114 sedentary age-matched controls.  Serum from these women was analyzed for complexed prostate specific antigen (cPSA) and free prostate specific antigen (fPSA), by fifth generation assays with limits of detection of around 6 and 140 fg/mL, respectively...
2017: F1000Research
https://www.readbyqxmd.com/read/28810889/dehydroepiandrosterone-sulfate-and-dehydroepiandrosterone-sulfate-cortisol-ratio-in-cirrhotic-patients-with-septic-shock-another-sign-of-hepatoadrenal-syndrome
#2
Ming-Hung Tsai, Hui-Chun Huang, Yun-Shing Peng, Yung-Chang Chen, Ya-Chung Tian, Chih-Wei Yang, Jau-Min Lien, Ji-Tseng Fang, Cheng-Shyong Wu, Sen-Yung Hsieh, Fa-Yauh Lee
BACKGROUND: Cirrhotic patients are susceptible to sepsis and critical illness-related corticosteroid insufficiency (CIRCI). Dehydroepiandrosterone sulfate (DHEAS) is a corticotropin-dependent adrenal androgen, which has immunostimulating and antiglucocorticoid effects. Considering the synchronized synthesis of cortisol and DHEAS and their opposing effects to each other, investigators have proposed measuring these two hormones as a ratio. Severe sepsis has been associated with low DHEAS, especially relative to high cortisol...
August 15, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28807679/identification-and-characterization-of-5%C3%AE-cyprinol-sulfating-cytosolic-sulfotransferases-sults-in-the-zebrafish-danio-rerio
#3
Katsuhisa Kurogi, Maki Yoshihama, Austin Horton, Isaac T Schiefer, Matthew D Krasowski, Lee R Hagey, Frederick E Williams, Yoichi Sakakibara, Naoya Kenmochi, Masahito Suiko, Ming-Cheh Liu
5α-Cyprinol 27-sulfate is the major biliary bile salt present in cypriniform fish including the zebrafish (Danio rerio). The current study was designed to identify the zebrafish cytosolic sulfotransferase (Sult) enzyme(s) capable of sulfating 5α-cyprinol and to characterize the zebrafish 5α-cyprinol-sulfating Sults in comparison with human SULT2A1. Enzymatic assays using zebrafish homogenates showed 5α-cyprinol-sulfating activity. A systematic analysis, using a panel of recombinant zebrafish Sults, revealed two Sult2 subfamily members, Sult2st2 and Sult2st3, as major 5α-cyprinol-sulfating Sults...
August 11, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28803991/dhea-increases-epithelial-markers-and-decreases-mesenchymal-proteins-in-breast-cancer-cells-and-reduces-xenograft-growth
#4
Zaira Colín-Val, Viridiana Yazmín González-Puertos, Criselda Mendoza-Milla, Erika Olivia Gómez, Claudia Huesca-Gómez, Rebeca López-Marure
Breast cancer is one of the most common neoplasias and the leading cause of cancer death in women worldwide. Its high mortality rate is linked to a great metastatic capacity associated with the epithelial-mesenchymal transition (EMT). During this process, a decrease in epithelial proteins expression and an increase of mesenchymal proteins are observed. On the other hand, it has been shown that dehydroepiandrosterone (DHEA), the most abundant steroid in human plasma, inhibits migration of breast cancer cells; however, the underlying mechanisms have not been elucidated...
August 10, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28800472/phthalate-and-bisphenol-a-exposure-during-in-utero-windows-of-susceptibility-in-relation-to-reproductive-hormones-and-pubertal-development-in-girls
#5
Deborah J Watkins, Brisa N Sánchez, Martha Maria Téllez-Rojo, Joyce M Lee, Adriana Mercado-García, Clara Blank-Goldenberg, Karen E Peterson, John D Meeker
BACKGROUND: Over the past several decades, the age of pubertal onset in girls has shifted downward worldwide. As early pubertal onset is associated with increased risky behavior and psychological issues during adolescence and cardiometabolic disease and cancer in adulthood, this is an important public health concern. Exposure to endocrine disrupting chemicals during critical windows of in utero development may play a role in this trend. Our objective was to investigate trimester-specific phthalate and BPA exposure in relation to pubertal development among girls in the Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) birth cohort...
August 8, 2017: Environmental Research
https://www.readbyqxmd.com/read/28789856/age-related-differences-in-stress-responsiveness-of-the-hypothalamic-pituitary-adrenal-axis-of-nonhuman-primates-with-various-types-of-adaptive-behavior
#6
Nadezhda D Goncharova, Tamara E Oganyan
Aging is characterized by disturbances in the functioning of the hypothalamic-pituitary-adrenal (HPA) axis, associated with disturbances in the adaptation processes and increase of the probability of the onset of post-stress syndrome. However, the individual features of age-related disorders stress reactivity of HPA axis have not been studied. The purpose was to study individual characteristics of the HPA axis responsiveness to acute psycho-emotional stress exposure (restraint, ASE) at different age periods on the model of the young adult and old physically healthy female rhesus monkeys that differ in their behavioral responses to stress, i...
August 5, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28782626/%C3%AE-4-3-ketosteroids-as-a-new-class-of-substrates-for-the-cytosolic-sulfotransferases
#7
Takuyu Hashiguchi, Katsuhisa Kurogi, Takehiko Shimohira, Takamasa Teramoto, Ming-Cheh Liu, Masahito Suiko, Yoichi Sakakibara
Cytosolic sulfotransferase (SULT)-mediated sulfation is generally known to involve the transfer of a sulfonate group from the active sulfate, 3'-phosphoadenosine 5'-phosphosulfate (PAPS), to a hydroxyl group or an amino group of a substrate compound. We report here that human SULT2A1, in addition to being able to sulfate dehydroepiandrosterone (DHEA) and other hydroxysteroids, could also catalyze the sulfation of Δ(4)-3-ketosteroids, which carry no hydroxyl groups in their chemical structure. Among a panel of Δ(4)-3-ketosteroids tested as substrates, 4-androstene-3,17-dione and progesterone were found to be sulfated by SULT2A1...
August 3, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28782595/dhea-supplementation-to-dexamethasone-treated-rabbits-alleviates-oxidative-stress-in-kidney-cortex-and-attenuates-albuminuria
#8
Anna Kiersztan, Nina Trojan, Aleksandra Tempes, Paweł Nalepa, Joanna Sitek, Katarzyna Winiarska, Michał Usarek
Our recent study has shown that dehydroepiandrosterone (DHEA) administered to rabbits partially ameliorated several dexamethasone (dexP) effects on hepatic and renal gluconeogenesis, insulin resistance and plasma lipid disorders. In the current investigation, we present the data on DHEA protective action against dexP-induced oxidative stress and albuminuria in rabbits. Four groups of adult male rabbits were used in the in vivo experiment: (1) control, (2) dexP-treated, (3) DHEA-treated and (4) both dexP- and DHEA-treated...
August 4, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28771887/acsl3-promotes-intratumoral-steroidogenesis-in-prostate-cancer-cells
#9
Toshiro Migita, Ken-Ichi Takayama, Tomohiko Urano, Daisuke Obinata, Kazutaka Ikeda, Tomoyoshi Soga, Satoru Takahashi, Satoshi Inoue
Long-chain acyl-coenzyme A (CoA) synthetase 3 (ACSL3) is an androgen-responsive gene involved in the generation of fatty acyl-CoA esters. ACSL3 is expressed in both androgen-sensitive and castration-resistant prostate cancer (CRPC). However, its role in prostate cancer remains elusive. We overexpressed ACSL3 in androgen-dependent LNCaP cells and examined the downstream effectors of ACSL3. Furthermore, we examined the role of ACSL3 in the androgen metabolism of prostate cancer. ACSL3 overexpression led to upregulation of several genes such as aldo-keto reductase 1C3 (AKR1C3) involved in steroidogenesis, which utilizes adrenal androgen dehydroepiandrosterone sulfate (DHEAS) as substrate, and downregulated androgen-inactivating enzyme UDP-glucuronosyltransferase 2 (UGT2B)...
August 3, 2017: Cancer Science
https://www.readbyqxmd.com/read/28765038/synergistic-effect-of-1%C3%AE-25-dihydroxyvitamin-d3-and-17%C3%AE-estradiol-on-osteoblast-differentiation-of-pediatric-mscs
#10
Jing Li, Bonnie L Padwa, Shuanhu Zhou, Julia Mullokandova, Meryl S LeBoff, Julie Glowacki
Vitamin D is essential for mineral homeostasis and contributes to bone metabolism by stimulating osteoblast differentiation of marrow stromal cells (MSCs). In this study, we used MSCs from pre-pubertal girls and boys to test the hypothesis that 1α,25(OH)2D and 17β-estradiol have synergistic effects on these MSCs, and what mechanism is involved. With IRB approval, we isolated MSCs from discarded excess iliac marrow graft from children undergoing alveolar cleft repair. Plasma was available from 8 female (9...
July 29, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28762529/the-impact-of-statin-use-on-the-efficacy-of-abiraterone-acetate-in-patients-with-castration-resistant-prostate-cancer
#11
Lauren C Harshman, Lillian Werner, Abhishek Tripathi, Xiaodong Wang, Benjamin L Maughan, Emmanuel S Antonarakis, Mari Nakabayashi, Rana McKay, Mark Pomerantz, Lorelei A Mucci, Mary-Ellen Taplin, Christopher J Sweeney, Gwo-Shu Mary Lee, Philip W Kantoff
BACKGROUND: Statins compete with DHEAS for influx through the SLCO2B1 transporter, which may prolong time to progression (TTP) on androgen deprivation therapy. Abiraterone acetate (AA) may also undergo SLCO-mediated transport. Based on preclinical findings showing antagonism, we hypothesized that statins may compete with AA for influx via SLCO2B1 and could negatively impact drug efficacy. METHODS: We queried two institutional clinical databases (Dana-Farber Cancer Institute [DFCI], Johns Hopkins University [JHU]) for CRPC patients treated with AA...
August 1, 2017: Prostate
https://www.readbyqxmd.com/read/28758852/dehydroepiandrosterone-supplementation-in-women-undergoing-assisted-reproductive-technology-with-poor-ovarian-response-a-prospective-case-control-study
#12
Haifa A Al-Turki
Objective The effects of dehydroepiandrosterone (DHEA) supplementation in Saudi Arabian women with poor ovarian response (POR) is presently unknown. The present study aimed to assess the benefits of DHEA supplementation in women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). Methods This was a prospective case-control study involving 62 women who were diagnosed with POR and underwent IVF/ICSI between January 2012 and June 2016. The positive influence of DHEA in 34 women, compared with 28 women without supplementation, was defined as improvements in the number of oocytes retrieved, the fertilization rate, the number of grade I embryos generated and the pregnancy rate...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28755980/profiling-coping-strategies-in-male-and-female-rats-potential-neurobehavioral-markers-of-increased-resilience-to-depressive-symptoms
#13
Molly Kent, Massimo Bardi, Ashley Hazelgrove, Kaitlyn Sewell, Emily Kirk, Brooke Thompson, Kristen Trexler, Brennan Terhune-Cotter, Kelly Lambert
Coping strategies have been associated with differential stress responsivity, perhaps providing a valuable neurobiological marker for susceptibility to the emergence of depressogenic symptoms or vulnerability to other anxiety-related disorders. Rats profiled with a flexible coping phenotype, for example, exhibit increased neurobiological markers of emotional regulation compared to active and passive copers (Bardi et al., 2012; Lambert et al., 2014). In the current study, responses of male and female rats to prediction errors in a spatial foraging task (dry land maze; DLM) were examined after animals were exposed to chronic unpredictable stress (CUS)...
August 3, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28752602/alterations-in-the-steroid-biosynthetic-pathways-in-the-human-prefrontal-cortex-in-mood-disorders-a-postmortem-study
#14
Xin-Rui Qi, Sabina Luchetti, Ronald W H Verwer, Arja A Sluiter, Matthew R J Mason, Jiang-Ning Zhou, Dick F Swaab
Altered levels of steroids have been reported in the brain, cerebral spinal fluid and plasma of patients with mood disorders. Neuroimaging studies have reported both functional and structural alterations in mood disorders, for instance in the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC). In order to determine whether the endogenous production of steroids is altered in the ACC and DLPFC of patients with major depressive disorder (MDD) or bipolar disorder (BPD), quantitative real-time PCR was performed to detect mRNA expression level of key enzymes in the steroid biosynthetic pathways...
July 27, 2017: Brain Pathology
https://www.readbyqxmd.com/read/28751368/functional-correlates-of-detailed-body-composition-in-healthy-elderly-subjects
#15
Corinna Geisler, Lisa Schweitzer, Manfred James Müller
Methods of body composition analysis (BCA) are now widely used to characterize health status, i.e. nutritional status, metabolic rates and cardio-metabolic risk factors. However, the functional correlates of individual body components have not been systematically analyzed. A 2-compartment model was assessed by air displacement plethysmographie, detailed body composition (BC)was measured by whole-body magnetic resonance imaging (MRI) in a healthy population of 40 Caucasians aged 65 to 81 years (20 males; body mass index range: 18...
July 27, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28751021/the-association-between-alcohol-abuse-and-neuroendocrine-system-dysregulation-race-differences-in-a-national-sample
#16
Yusuf Ransome, Natalie Slopen, Oskar Karlsson, David R Williams
Health outcomes, including chronic disease and mortality, attributed to or associated with alcohol abuse are discrepant between African Americans and Whites. To date, the topic is not fully understood and few studies conducted have used biomarker indicators of health. We investigated whether the association between alcohol abuse and biomarkers of the neuroendocrine system vary between black or African American and White respondents aged 34 to 84 from the Midlife in the United States Study (MIDUS) II (2004-2006) (n =1,129)...
July 24, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28750898/the-use-of-a-unique-co-culture-model-of-fetoplacental-steroidogenesis-as-a-screening-tool-for-endocrine-disruptors-the-effects-of-neonicotinoids-on-aromatase-activity-and-hormone-production
#17
Elyse Caron-Beaudoin, Rachel Viau, Andrée-Anne Hudon-Thibeault, Cathy Vaillancourt, J Thomas Sanderson
Estrogen biosynthesis during pregnancy is dependent on the collaboration between the fetus producing the androgen precursors, and the placenta expressing the enzyme aromatase (CYP19). Disruption of estrogen production by contaminants may result in serious pregnancy outcomes. We used our recently developed in vitro co-culture model of fetoplacental steroidogenesis to screen the effects of three neonicotinoid insecticides on the catalytic activity of aromatase and the production of steroid hormones. A co-culture of H295R human adrenocortical carcinoma cells with fetal characteristics and BeWo human choriocarcinoma cells which display characteristics of the villous cytotrophoblast was exposed for 24h to various concentrations of three neonicotinoids: thiacloprid, thiamethoxam and imidacloprid...
July 24, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28744698/association-of-basal-serum-androgen-levels-with-ovarian-response-and-icsi-cycle-outcome
#18
C Abide Yayla, E Ozkaya, S Kayatas Eser, I Sanverdi, B Devranoglu, T Kutlu
BACKGROUND: The purpose of this study was to assess the predictive value of basal serum testosterone (T) and dehydroepiandrosterone sulfate (DHEAS) levels during follicular phase for ovarian response and outcome in intracytoplasmic sperm injection (ICSI) cycles of women with diminished ovarian reserve. METHODS: We prospectively gathered data of basal serum androgen levels and ICSI cycle characteristics of 120 women with diminished ovarian reserve. Association of basal serum T and DHEAS levels with ovarian response was analyzed...
July 25, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28742984/single-versus-combined-immunoregulatory-approach-using-pd-1-and-ctla-4-modulators-in-controlling-sepsis
#19
Courtney P Rudick, David L Cornell, Devendra K Agrawal
Sepsis is a disease process characterized by an extreme inflammatory response followed by a period of severe immunosuppression. In recent years, there has been improved survival in the initial immune response during systemic inflammatory response syndrome, and compensatory anti-inflammatory response, yet is mostly unchanged with 18-30% mortality during the later stage of sepsis despite numerous Phase 3 clinical trials. Areas covered: This review article presents a critical evaluation of the most promising newer studies aimed at improving the immunosuppressive stage of sepsis...
September 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28739331/associations-of-sex-hormones-and-anthropometry-with-the-speaking-voice-profile-in-the-adult-general-population
#20
Lasse Jost, Michael Fuchs, Markus Loeffler, Joachim Thiery, Juergen Kratzsch, Thomas Berger, Christoph Engel
OBJECTIVE: There is evidence that sexual hormone concentrations and anthropometric factors influence the human voice. The goal of this study was to investigate to what extent body mass index (BMI), body height, body weight, breast-to-abdomen-ratio, testosterone, estradiol, dehydroepiandrosterone-sulfate (DHEA-S), follicle-stimulating hormone, and luteinizing hormone are associated with the sound pressure level and the fundamental frequency of the speaking voice in a cross-sectional approach among adults in the general population...
July 21, 2017: Journal of Voice: Official Journal of the Voice Foundation
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