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https://www.readbyqxmd.com/read/29164484/association-between-cortisol-to-dhea-s-ratio-and-sickness-absence-in-japanese-male-workers
#1
Kumi Hirokawa, Yasuhito Fujii, Toshiyo Taniguchi, Jiro Takaki, Akizumi Tsutsumi
PURPOSE: This study aimed to investigate the association between serum levels of cortisol and dehydroepiandrosterone sulfate (DHEA-s) and sickness absence over 2 years in Japanese male workers. METHOD: A baseline survey including questions about health behavior, along with blood sampling for cortisol and DHEA-s, was conducted in 2009. In total, 429 men (mean ± SD age, 52.9 ± 8.6 years) from whom blood samples were collected at baseline were followed until December 31, 2011...
November 21, 2017: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29164377/systemic-and-local-effects-of-vaginal-dehydroepiandrosterone-dhea-ncctg-n10c1-alliance
#2
Debra L Barton, Lynne T Shuster, Travis Dockter, Pamela J Atherton, Jacqueline Thielen, Stephen N Birrell, Richa Sood, Patricia Griffin, Shelby A Terstriep, Bassam Mattar, Jacqueline M Lafky, Charles L Loprinzi
BACKGROUND: Dehydroepiandrosterone (DHEA) is helpful for treating vaginal symptoms. This secondary analysis evaluated the impact of vaginal DHEA on hormone concentrations, bone turnover, and vaginal cytology in women with a cancer history. METHODS: Postmenopausal women, diagnosed with breast or gynecologic cancer, were eligible if they reported at least moderate vaginal symptoms. Participants could be on tamoxifen or aromatase inhibitors (AIs). Women were randomized to 3...
November 21, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29155118/patterns-of-neuroendocrine-coupling-in-9-year-old-children-effects-of-sex-body-mass-index-and-life-stress
#3
Sarah R Black, Matthew D Lerner, Elizabeth A Shirtcliff, Daniel N Klein
Previous investigations have explored stress and pubertal hormones in parallel; it has been a recent development, however, to explore the relationships between different hormones during puberty, and how this hormonal cross-talk may be influenced by the environment. The current study investigated neuroendocrine coupling, or the extent to which hormones are correlated within the individual, and also investigated early life stressors that may influence coupling. Participants were 405 adrenarcheal children (mean Tanner stage=1...
November 16, 2017: Biological Psychology
https://www.readbyqxmd.com/read/29147745/steroid-hormone-profiling-in-human-breast-adipose-tissue-using-semi-automated-purification-and-highly-sensitive-determination-of-estrogens-by-gc-apci-ms-ms
#4
Kristin Hennig, Jean Philippe Antignac, Emmanuelle Bichon, Marie-Line Morvan, Isabelle Miran, Suzette Delaloge, Jean Feunteun, Bruno Le Bizec
Body mass index is a known breast cancer risk factor due to, among other mechanisms, adipose-derived hormones. We developed a method for steroid hormone profiling in adipose tissue to evaluate healthy tissue around the tumor and define new biomarkers for cancer development. A semi-automated sample preparation method based on gel permeation chromatography and subsequent derivatization with trimethylsilyl (TMS) is presented. Progestagens and androgens were determined by GC-EI-MS/MS (LOQ 0.5 to 10 ng/g lipids)...
November 16, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29144993/evaluate-the-effects-of-antiepileptic-drugs-on-reproductive-endocrine-system-in-newly-diagnosed-female-epileptic-patients-receiving-either-valproate-or-lamotrigine-monotherapy-a-prospective-study
#5
Harpreet Singh Sidhu, R Srinivasa, Akshay Sadhotra
OBJECTIVE: To investigate the development of reproductive endocrine changes in Indian women with epilepsy initiating on either Valproate (VPA) or Lamotrigine (LTG) monotherapy. METHODS: Reproductive hormonal profiles, hirsutism, ovarian morphology by ultrasonography and menstrual cycle data in newly diagnosed women with epilepsy taking VPA (n=34) or LTG (n=32) monotherapy were compared. None of the women were receiving hormonal contraception. Patients gave details of seizure type and frequency, medical and drug history...
October 28, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29144805/dpp4-inhibitor-sitagliptin-as-a-potential-treatment-option-in-metformin-intolerant-obese-women-with-polycystic-ovary-syndrome-a-pilot-randomized-study
#6
Simona Ferjan, Andrej Janez, Mojca Jensterle
OBJECTIVE: Metformin has an established role in the management of polycystic ovary syndrome (PCOS). Some patients cannot tolerate it due to associated gastrointestinal adverse events. The present study evaluated DPP4 inhibitor sitagliptin as a potential treatment option in metformin intolerant PCOS. DESIGN: We conducted a 12-week prospective randomized open-label study with 30 obese metformin intolerant women with PCOS (aged 35.0±7.2 years, BMI 36.9±5.5 kg/m(2))...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29141871/potential-approaches-to-prevent-hypoglycemia-associated-autonomic-failure
#7
REVIEW
Eric Lontchi-Yimagou, Jee Young You, Michelle Carey, Ilan Gabriely, Harry Shamoon, Meredith Hawkins
Clear health benefits are associated with intensive glucose control in type 1 diabetes mellitus (T1DM). However, maintaining near-normal glycemia remains an elusive goal for many patients, in large part owing to the risk of severe hypoglycemia. In fact, recurrent episodes of hypoglycemia lead to 'hypoglycemia-associated autonomic failure' (HAAF), characterized by defective counter-regulatory responses to hypoglycemia. Extensive studies to understand the mechanisms underlying HAAF have revealed multiple potential etiologies, suggesting various approaches to prevent the development of HAAF...
November 14, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29127580/sigma-1-receptor-agonists-induce-oxidative-stress-in-mitochondria-and-enhance-complex-i-activity-in-physiological-condition-but-protect-against-pathological-oxidative-stress
#8
Nino Goguadze, Elene Zhuravliova, Didier Morin, Davit Mikeladze, Tangui Maurice
The sigma1 receptor (σ1R) is a chaperone protein residing at mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), where it modulates Ca(2+) exchange between the ER and mitochondria by interacting with inositol-1,4,5 trisphosphate receptors (IP3Rs). The σ1R is highly expressed in the central nervous system and its activation stimulates neuromodulation and neuroprotection, for instance in Alzheimer's disease (AD) models in vitro and in vivo. σ1R effects on mitochondria pathophysiology and the downstream signaling are still not fully understood...
November 10, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/29126147/adrenocorticotropin-acutely-regulates-pregnenolone-sulfate-production-by-the-human-adrenal-in-vivo-and-in-vitro
#9
Juilee Rege, Aya T Nanba, Richard J Auchus, Jianwei Ren, Hwei-Ming Peng, William E Rainey, Adina F Turcu
Background: Dehydroepiandrosterone sulfate (DHEAS) is the most abundant steroid in human circulation, and ACTH is considered the major regulator of its synthesis. Pregnenolone sulfate (PregS) and 5-Androstenediol-3-sulfate (AdiolS) have recently emerged as biomarkers of adrenal disorders. Objective: To define the relative human adrenal production of ∆5-steroid sulfates under basal and cosyntropin-stimulated conditions. Methods: Liquid chromatography-tandem mass spectrometry was used to quantify three unconjugated and four sulfated ∆5-steroids in: 1) paired adrenal vein (AV) and mixed venous serum samples (21 patients), and 2) cultured human adrenal cells, both before and after cosyntropin stimulation; 3) microdissected zona fasciculata (ZF) and zona reticularis (ZR) from 5 human adrenal glands; 4) reconstituted in vitro human 17α-hydroxylase/17,20-lyase (CYP17A1/ P450 17A1) system...
November 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29114265/dehydroepiandrosterone-sulfate-insulin-resistance-and-ovarian-volume-estimation-in-patients-with-polycystic-ovarian-syndrome
#10
Chrysi Christodoulaki, Eftihios Trakakis, Vasilios Pergialiotis, Periklis Panagopoulos, Charalampos Chrelias, Dimitrios Kassanos, Dimos Sioutis, Nikolaos Papantoniou, Dimitrios Xirofotos
Objective: To investigate the potential association of DHEA-S with metabolic and hormonal alterations and with disorders of ovarian morphology. Materials and methods: The present study was based on women with PCOS that attended the Gynaecological Endocrinology - Paediatric and Adolescence Endocrinology Department of our clinic. Overall, 321 patients who met the Rotterdam ESHRE/ ASRM - Sponsored criteria for the definition of PCOS were included. Women's personal medical history was recorded, anthropometric parameters were assessed and blood was drawn for analysis of metabolic and hormonal parameters...
March 2017: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/29113921/antihypertensive-responses-of-vasoactive-androgens-in-an-in-vivo-experimental-model-of-preeclampsia
#11
Mercedes Perusquía, Andrea E Hanson, Claudia M Meza, Cris Kubli, Nieves Herrera, John N Stallone
Dehydroepiandrosterone (DHEA), testosterone (TES) and its 5-reduced metabolites induce a nongenomic vasorelaxation in several vascular beds of mammals; similarly these hormones produce systemic hypotensive and antihypertensive responses in normotensive and hypertensive male rats. Thus, it was hypothesized that the antihypertensive response of androgens, whose levels are elevated during gestation, protect against gestational hypertension. An animal model of preeclampsia was induced in female Wistar rats using DOCA-salt-treated pregnant (PT) and normal pregnant (NP) rats...
November 4, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29112780/associations-of-lifestyle-factors-with-serum-dehydroepiandrosterone-sulfate-and-insulin-like-growth-factor-1-concentration-in-prepubertal-children
#12
Aino Mäntyselkä, Jarmo Jääskeläinen, Aino-Maija Eloranta, Juuso Väistö, Raimo Voutilainen, Ken Ong, Soren Brage, Timo A Lakka, Virpi Lindi
OBJECTIVE: Little is known about the relationships of dietary factors, physical activity, and sedentary behavior to dehydroepiandrosterone sulfate (DHEAS) and insulin-like growth factor-1 (IGF-1) concentrations among prepubertal children. Therefore, we studied the associations of these lifestyle factors with serum DHEAS and IGF-1 in children. DESIGN AND SUBJECTS: Cross-sectional analysis of a population sample of 431 prepubertal children aged 6-9 years. MEASUREMENTS: Assessment of dietary factors by food records and physical activity and sedentary behavior by a combined heart rate and movement monitor and a questionnaire...
November 7, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29110281/the-effect-of-vitamin-d-supplementation-in-combination-with-low-calorie-diet-on-anthropometric-indices-and-androgen-hormones-in-women-with-polycystic-ovary-syndrome-a-double-blind-randomized-placebo-controlled-trial
#13
S Jafari-Sfidvajani, R Ahangari, M Hozoori, H Mozaffari-Khosravi, H Fallahzadeh, A Nadjarzadeh
PURPOSE: Polycystic ovary syndrome (PCOS) is known as the most common endocrine disorder in reproductive age women. The aim of this studywas to evaluate the effects of vitamin D supplementation in combination with low-calorie diet on anthropometric indices, reproductive hormones and menstrual regularity in overweight and obese PCOS women. METHODS: In this randomized controlled clinical trial, 60 PCOS women with vitamin D insufficiency were randomly assigned to 12 weeks of either (1) weight-loss intervention + 50,000 IU/week oral vitamin D3 or (2) weight-loss intervention + placebo...
November 6, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29110028/quantification-of-dehydroepiandrosterone-in-human-serum-on-a-routine-basis-development-and-validation-of-a-tandem-mass-spectrometry-method-based-on-a-surrogate-analyte
#14
Beatrice Campi, Sabina Frascarelli, Elisabetta Pietri, Ilaria Massa, Caterina Donati, Roberto Bozic, Silvano Bertelloni, Aldo Paolicchi, Riccardo Zucchi, Alessandro Saba
In the clinical laboratories, dehydroepiandrostenedione (DHEA) is usually quantified by immunoassay-based methods, which are often affected by cross-reactivity with endogenous interferences, such as 4-androsten-3β-ol-17-one. The interfering compounds lead to a poor accuracy of the measurements, mainly at a low concentration level. The present paper describes a validated method based on tandem mass spectrometry coupled to liquid chromatography, for the accurate quantification of DHEA in serum. The peculiarity of this method is the use of calibrators and quality controls prepared by adding measured amounts of DHEA-D5, a stable isotope-labeled analogue of DHEA, to real serum from healthy subjects...
November 6, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29091323/lower-levels-of-dehydroepiandrosterone-sulfate-are-associated-with-more-advanced-liver-fibrosis-in-chronic-hepatitis-c
#15
João Marcello de Araujo Neto, Henrique Sérgio Moraes Coelho, Maria Chiara Chindamo, Guilherme Ferreira da Motta Rezende, Vera Lúcia Nunes Pannain, Adriana Marques Caroli de Freitas Bottino, Luiz Fernando Bruzzi Porto, Ronir Raggio Luiz, Cristiane Alves Villela-Nogueira, Renata M Perez
Chronic infection with the hepatitis C virus induces liver fibrosis, but it is unknown why some patients progress to advanced fibrosis while others remain with mild disease. Recently, an inverse association between serum levels of dehydroepiandrosterone sulphate (DHEA-S) and liver fibrosis in patients with nonalcoholic fatty liver disease was described and it was postulated that dehydroepiandrosterone (DHEA) has anti-fibrotic effects. Our aim was to compare serum DHEA-S levels with liver fibrosis in hepatitis C patients...
November 1, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29073797/features-of-polycystic-ovary-syndrome-pcos-in-women-with-functional-hypothalamic-amenorrhea-fha-may-be-reversible-with-recovery-of-menstrual-function
#16
Enrico Carmina, Franca Fruzzetti, Roger A Lobo
OBJECTIVE: Since features of polycystic ovary syndrome (PCOS) have been found to be prevalent in women with functional hypothalamic amenorrhea (FHA), we wished to determine what happens to these features after recovery of menstrual function in FHA Design: Prospective cohort study. Twenty-eight women with FHA and 30 age-matched ovulatory controls were studied. METHODS: Twenty-eight women with FHA and 30 age-matched ovulatory controls were studied. We measured serum estradiol, LH, FSH, testosterone, DHEAS, anti-Mullerian hormone (AMH), body mass index, and ovarian morphology on transvaginal ultrasound...
October 27, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29073790/efficacy-of-dehydroepiandrosterone-dhea-supplementation-for-in-vitro-fertilization-and-embryo-transfer-cycles-a-systematic-review-and-meta-analysis
#17
Yaofang Liu, Lina Hu, Lingye Fan, Fang Wang
Dehydroepiandrosterone (DHEA) supplementation might hold some promise in vitro fertilization and embryo transfer cycles. However, the results remain controversial. We conducted a systematic review and meta-analysis to evaluate the efficacy of DHEA in patients for in vitro fertilization. PubMed, EMbase, Web of science, EBSCO and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of DHEA versus placebo on in vitro fertilization were included. Two investigators independently searched articles, extracted data and assessed the quality of included studies...
October 26, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29068579/usefulness-of-a-new-anthropometric-indicator-vai-visceral-adiposity-index-in-the-evaluation-of-metabolic-and-hormonal-disorders-in-women-with-polycystic-ovary-syndrome
#18
Anna Brończyk-Puzoń, Paweł Jagielski, Karolina Kulik-Kupka, Aneta Koszowska, Justyna Nowak, Barbara Zubelewicz-Szkodzińska
BACKGROUND: Visceral adiposity index (VAI) is a new anthropometric indicator that makes it possible to define the risk of obesity-related cardiometabolic complications even before the diagnosis of metabolic syndrome. OBJECTIVES: Evaluating the usefulness of VAI in order to differentiate metabolically unhealthy women (MU-PCOS) and defining the usefulness of this index in everyday practice. MATERIAL AND METHODS: A prospective study was conducted among 43 women who met the Rotterdam criteria for diagnosing polycystic ovarian syndrome...
August 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29068242/heterogenous-origins-of-hyperandrogenism-in-the-polycystic-ovary-syndrome-in-relation-to-body-mass-index-and-insulin-resistance
#19
Shalini Patlolla, Suresh Vaikkakara, Alok Sachan, Ashok Venkatanarasu, Bharath Bachimanchi, Aparna Bitla, Sarala Settipalli, Sumathi Pathiputturu, Roopa Naik Sugali, Sravani Chiri
BACKGROUND: Insulin resistance and obesity are not universal features of polycystic ovary syndrome (PCOS). We planned to assess the differences between patients with nonobese /insulin-sensitive phenotype vs. obese/ insulin-resistant phenotype in terms of the potential mechanisms underlying their hyperandrogenism. MATERIALS AND METHODS: A total of 52 women satisfying Androgen Excess Society (AES) criteria were included. Hormonal and metabolic profile including prolactin, dehydroepiandrosterone sulfate (DHEAS), free testosterone, sex hormone binding globulin (SHBG), fasting plasma glucose and insulin were measured in follicular phase...
October 25, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29067249/serum-dehydroepiandrosterone-sulfate-in-assessing-the-integrity-of-the-hypothalamic-pituitary-adrenal-axis
#20
Suranut Charoensri, Laor Chailurkit, Dittapol Muntham, Pongamorn Bunnag
OBJECTIVE: To evaluate the relationship between age- and gender-adjusted dehydroepiandrosterone sulfate (DHEA-S) levels and low-dose adrenocorticotropic hormone (ACTH) stimulation in assessing the integrity of the hypothalamic-pituitary-adrenal (HPA) axis, in patients who were at risk of HPA insufficiency, including those currently being treated with glucocorticoids. METHODS: Forty-six participants with a suspicion of secondary adrenal insufficiency were recruited from the Diabetes and Endocrinology Clinic at Ramathibodi Hospital, Mahidol University, Bangkok...
March 2017: Journal of Clinical & Translational Endocrinology
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