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https://www.readbyqxmd.com/read/29782310/putative-gonadotropin-releasing-hormone-agonist-therapy-and-dementia-an-application-of-medicare-hospitalization-claims-data
#1
Mark A Smith, Richard L Bowen, Richard Q Nguyen, George Perry, Craig S Atwood, Alfred A Rimm
BACKGROUND: Estrogen and hormone replacement therapies to reduce Alzheimer's disease (AD) have yielded conflicting results. However, this study proposes that the well-characterized increase in serum gonadotropins following menopause or andropause are accountable for the increased risk of developing AD among the elderly population. OBJECTIVE: To determine the role of gonadotropins in the development of AD and investigate gonadotropin-releasing hormone (GnRH) agonist therapy as a potential preventative and/or disease-modifying approach to AD management...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29743865/somatopause-weaknesses-of-the-therapeutic-approaches-and-the-cautious-optimism-based-on-experimental-ageing-studies-with-soy-isoflavones
#2
REVIEW
Vladimir Z Ajdžanovic, Svetlana Trifunovic, Dragana Miljic, Branka Šošic-Jurjevic, Branko Filipovic, Marko Miler, Nataša Ristic, Milica Manojlovic-Stojanoski, Verica Miloševic
The pathological phenomenon of somatopause, noticeable in hypogonadal ageing subjects, is based on the growth hormone (GH) production and secretion decrease along with the fall in GH binding protein and insulin-like growth factor 1 (IGF-1) levels, causing different musculoskeletal, metabolic and mental issues. From the perspective of safety and efficacy, GH treatment is considered to be highly controversial, while some other therapeutic approaches (application of IGF-1, GH secretagogues, gonadal steroids, cholinesterase-inhibitors or various combinations) exhibit more or less pronounced weaknesses in this respect...
2018: EXCLI journal
https://www.readbyqxmd.com/read/29528085/soy-isoflavone-effects-on-the-adrenal-glands-of-orchidectomized-adult-male-rats-a-comprehensive-histological-and-hormonal-study
#3
Verica Lj Milošević, Walter B Severs, Nataša M Ristić, Milica N Manojlović-Stojanoski, Florina V Popovska-Perčinić, Branka T Šošić-Jurjević, Lazo B Pendovski, Svetlana L Trifunović, Marko Š Miler, Vladimir Z Ajdžanović
Genistein (G) and related soy phytoestrogens have been studied for potential usefulness in different chronic diseases, and may ameliorate signs of aging. They have a profound influence on the hypothalamo-pituitary-adrenal (HPA) axis. The present study utilized the rat model of mild andropause to thoroughly evaluate the effects of G and soy extract on the adrenal gland and related blood hormones. Adult male rats were orchidectomized (Orx) or sham operated (SO). Orx rats received daily subcutaneous injections for 3 weeks of solvent, or G (Orx+G, 30 mg/kg), or commercial soy extract (Orx+Soy, 30 mg/kg)...
March 12, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29371146/couplepause-a-new-paradigm-in-treating-sexual-dysfunction-during-menopause-and-andropause
#4
REVIEW
Emmanuele A Jannini, Rossella E Nappi
BACKGROUND: At midlife and beyond, both men and women face organic changes that can affect sexual functioning. For women, ovarian exhaustion causes estrogen deficiency, leading to genitourinary syndrome of menopause, which may include vaginal dryness, irritation/itching, inadequate lubrication, and dyspareunia. Hypoactive sexual desire disorder also can result from biopsychosocial factors. For men, erectile dysfunction prevalence increases with age, and some men develop testosterone deficiency...
January 19, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29307303/hormones-and-ms-risk-factors-biomarkers-and-therapeutic-targets
#5
Riley Bove, Wendy Gilmore
Sex differences in epidemiological, clinical, and pathological features of multiple sclerosis (MS) have been observed for decades, establishing a foundation for more recent progress in our understanding of their overall impact on the disease. In the ACTRIMS session on Hormones, Sex Chromosomes, and MS: Risk Factors, Biomarkers, and Therapeutic Targets, this progress was summarized in three presentations by pioneers in the field, revealing evidence that sex chromosomes, epigenetic factors, and sex hormones function as interactive determinants of disease risk and phenotype in a fashion dependent upon life stage, from prenatal development, childhood, and adolescence to adulthood and aging...
January 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29282701/towards-icf-implementation-in-menopause-healthcare-a-systematic-review-of-icf-application-in-switzerland
#6
Martina Zangger, Dagmar Poethig, Florian Meissner, Michael von Wolff, Petra Stute
AIMS OF THE STUDY: To present a systematic literature review on the application and degree of implementation of the International Classification of Functioning, Disability and Health (ICF) across different health conditions and regions in Switzerland in order to develop an ICF classification of the climacteric syndrome in the medium term. METHODS: A systematic literature search was conducted through Embase and Medline covering the period between 2011 and August 2016...
December 28, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29075365/antioxidant-and-antifibrotic-effect-of-a-herbal-formulation-in-vitro-and-in-the-experimental-andropause-via-nrf2-ho-1-signaling-pathway
#7
Woong Jin Bae, Guan Qun Zhu, Sae Woong Choi, Hyun Cheol Jeong, Fahad Bashraheel, Kang Sup Kim, Su Jin Kim, Hyuk Jin Cho, U Syn Ha, Sung Hoo Hong, Ji Youl Lee, Hyun-A Oh, Hye Cheong Koo, Do Ram Kim, Sung Yeoun Hwang, Sae Woong Kim
The Korean herbal formulation Ojayeonjonghwan is used for improving late-onset hypogonadism (LOH) symptoms such as erectile dysfunction (ED). A previous research suggested that a modified Ojayeonjonghwan (KH-204) could be used as an alternative to the treatment for ED. The pharmacological effects were examined in different conditions, including in vitro and in vivo. We measured the survival rate of TM3 Leydig cells under the oxidative stress condition. The s.c. injection of leuprorelin was used to induce androgen deprivation...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29065996/joint-opinion-paper-ageing-and-sexual-health-by-the-european-board-college-of-obstetrics-and-gynaecology-ebcog-and-the-european-menopause-and-andropause-society-emas
#8
REVIEW
Margaret Rees, Irene Lambrinoudaki, Johannes Bitzer, Tahir Mahmood
No abstract text is available yet for this article.
January 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28975776/menopause-and-hormone-replacement-therapy-the-2017-recommendations-of-the-italian-menopause-society
#9
Marco Gambacciani, Nicoletta Biglia, Angelo Cagnacci, Salvatore Caruso, Ettore Cicinelli, Vincenzo DE Leo, Costantino DI Carlo, Manuela Farris, Alessandro Gambera, Secondo Guaschino, Antonio Lanzone, Anna M Paoletti, Novella Russo, Franco Vicariotto, Paola Villa, Annibale Volpe
Over the last decade, the risk benefits ratio of hormone replacement therapy (HRT) has been reevaluated mainly in tens of cardiovascular risk. Present Consensus Statement is largely inspired by the Global Consensus on Menopausal Hormone Therapy in 2013 and 2016 by leading global menopause societies (The American Society for Reproductive Medicine, The Asia Pacific Menopause Federation, The Endocrine Society, The European Menopause and Andropause Society, The International Menopause Society, The International Osteoporosis Foundation and The North American Menopause Society)...
February 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/28831925/diabetes-mellitus-and-male-aging-pharmacotherapeutics-and-clinical-implications
#10
Swathi Putta, Ilaria Peluso, Nagendra Sastry Yarla, Eswar Kumar Kilari, Anupam Bishayee, Da-Yong Lu, George E Barreto, Ghulam Md Ashraf, Luciana Scotti, Marcus T Scotti, Rajeev K Singla, Thonos Alexiou, Atanas G Atanasov, Vadim V Tarasov, P Veera Bramhachari, Sarat Babu Imandi, Madhuri Chintala, Bechan Sharma, Marcella Reale, Rosanna Filosa, Gjumrakch Aliev, Mohammad Amjad Kamal
Andropause or male menopause is defined as androgen decline and onset of hypogonadism in the aging male. Testosterone deficiency in adult male is associated with diabetes mellitus, coronary artery disease, and heart failure. Type 2 diabetic male patients aged above 30 years showed low testosterone levels which is common in diabetic men and had symptoms of hypogonadism. Male sexual dysfunction among diabetic patients can include disorders of libido, ejaculatory problems, and erectile dysfunctions are common among people with diabetes, particularly in older men who had diabetes for years...
August 22, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28817241/association-between-vitamin-d-deficiency-and-heart-failure-risk-in-the-elderly
#11
Catarina Magalhães Porto, Vanessa De Lima Silva, João Soares Brito da Luz, Brivaldo Markman Filho, Vera Magalhães da Silveira
AIMS: The aim of this study was to evaluate the association between vitamin D deficiency and risk of heart failure in elderly patients of cardiology outpatient clinics. METHODS AND RESULTS: A cross-sectional study with an analytical approach was employed. Clinical data were collected from the elderly from August 2015 to February 2016. The dependent variable was the risk of heart failure; the independent variable was vitamin D deficiency; and intervening factors were age, gender, education, ethnicity, hypertension, diabetes mellitus, hypothyroidism, renal failure, dementia, stroke, dyslipidaemia, depression, smoking, alcoholism, obesity, andropause, and cardiac arrhythmia...
February 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/28777369/-obstructive-sleep-apnea-syndrome-and-age-related-hypohonadism
#12
I M Madaeva, O N Berdina, N V Semenova, V V Madaev, L V Rychkova, L I Kolesnikova
BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is a common disease that causes a different spectrum of life processes violations in the continuum of 'sleep-wakefulness'. OSAS in combination with age-specific hypogonadism as a systemic pathology requires certain interdisciplinary approaches involving both the correction of the obstruction, and testosterone therapy in men with hypogonadism. AIM: Assessment of the effect of combined use of CPAP (Continuous Positive Airway Pressure) and testosterone replacement therapy (transdermal form - Androgel) on indicators of polysomnography monitoring (PSG) with simultaneous study of erectile function and testosterone secretion...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28713963/sexual-dimorphism-of-frailty-and-cognitive-impairment-potential-underlying-mechanisms-review
#13
REVIEW
Qingwei Ruan, Grazia D'onofrio, Tao Wu, Antonio Greco, Daniele Sancarlo, Zhuowei Yu
The aim of the present study was to assess systematically gender differences in susceptibility to frailty and cognitive performance decline, and the underlying mechanisms. A systematic assessment was performed of the identified reviews of cohort, mechanistic and epidemiological studies. The selection criteria of the present study included: i) Sexual dimorphism of frailty, ii) sexual dimorphism of subjective memory decline (impairment) and atrophy of hippocampus during early life, iii) sexual dimorphism of late‑onset Alzheimer's disease and iv) sexual dimorphism mechanisms underlying frailty and cognitive impairment...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28650892/the-2017-hormone-therapy-position-statement-of-the-north-american-menopause-society
#14
(no author information available yet)
The 2017 Hormone Therapy Position Statement of The North American Menopause Society (NAMS) updates the 2012 Hormone Therapy Position Statement of The North American Menopause Society and identifies future research needs. An Advisory Panel of clinicians and researchers expert in the field of women's health and menopause was recruited by NAMS to review the 2012 Position Statement, evaluate new literature, assess the evidence, and reach consensus on recommendations, using the level of evidence to identify the strength of recommendations and the quality of the evidence...
June 22, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28650869/the-2017-hormone-therapy-position-statement-of-the-north-american-menopause-society
#15
(no author information available yet)
The 2017 Hormone Therapy Position Statement of The North American Menopause Society (NAMS) updates the 2012 Hormone Therapy Position Statement of The North American Menopause Society and identifies future research needs. An Advisory Panel of clinicians and researchers expert in the field of women's health and menopause was recruited by NAMS to review the 2012 Position Statement, evaluate new literature, assess the evidence, and reach consensus on recommendations, using the level of evidence to identify the strength of recommendations and the quality of the evidence...
July 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28539995/the-effect-of-luteinizing-hormone-reducing-agent-on-anxiety-and-novel-object-recognition-memory-in-gonadectomized-rats
#16
Paria Arfa-Fatollahkhani, Arezo Nahavandi, Hossein Abtahi, Shabnam Anjidani, Sahar Borhani, Seyed Behnam Jameie, Mohammad Shabani, Saeed Mehrzadi, Ali Shahbazi
INTRODUCTION: Mood disorders such as anxiety and depression are common following menopause and andropause. Lack of sex steroid hormones is suggested as the primary cause of these disturbances. The level of luteinizing hormone (LH) would also rise 3-4 times than normal in these people. The potential effects of LH on mood and cognitive symptoms following menopause and andropause are still unknown. This study aimed to investigate the effect of increased LH on novel object discrimination (NOD) memory and anxiety like behavior in gonadectomized rats...
March 2017: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/28485654/awareness-and-experience-of-andropause-symptoms-in-men-referring-to-health-centers-a-cross-sectional-study-in-iran
#17
Forough Samipoor, Sedigheh Pakseresht, Parvaneh Rezasoltani, Ehsan Kazemnajad Leili
INTRODUCTION: Andropause is a gradual process and more similar to menopause in women. Knowledge and experience of symptoms of andropause is an important discussion is in their lives. OBJECTIVES: This study aimed to determine Awareness and Experience of Andropause Symptoms in Men referring to Health Centers in Rasht, Iran. MATERIALS AND METHODS: This cross-sectional and analytical study included 140 men over 40 years referring to one of health centers...
September 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28443210/erratum-to-bcl-2-expression-is-a-poor-predictor-for-hepatocellular-carcinoma-prognosis-of-andropause-age-patients
#18
Xiao-Fei Zhang, Xin Yang, Hu-Liang Jia, Wen-Wei Zhu, Lu Lu, Wei Shi, Hao Zhang, Jin-Hong Chen, Yi-Feng Tao, Zheng-Xin Wang, Jun Yang, Lian-Xin Wang, Ming Lu, Yan Zheng, Jing Zhao, Qiong-Zhu Dong, Lun-Xiu Qin
No abstract text is available yet for this article.
February 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28389043/interventions-to-reduce-the-risk-of-ovarian-and-fallopian-tube-cancer-a-european-menopause-and-andropause-society-postition-statement
#19
REVIEW
Faustino R Pérez-López, Iuliana Ceausu, Herman Depypere, Sean Kehoe, Irene Lambrinoudaki, Alfred Mueck, Levent M Senturk, Tommaso Simoncini, John C Stevenson, Petra Stute, Margaret Rees
BACKGROUND: Ovarian cancer is a leading cause of female gynecological cancer-related death, and there are no effective screening procedures or early diagnostic approaches. AIMS: To examine risk factors and risk-reducing strategies for both sporadic and familial tumors. MATERIALS AND METHODS: Literature review and consensus of expert opinion. RESULTS AND CONCLUSIONS: In women with a genetic predisposition to ovarian cancer, salpingo-oophorectomy reduces the risk of ovarian malignancy, and to a lesser degree of breast cancer...
June 2017: Maturitas
https://www.readbyqxmd.com/read/28363155/novel-aryl-piperazines-for-alleviation-of-andropause-associated-prostatic-disorders-and-depression
#20
Sonal Gupta, Deepti Pandey, Dhanaraju Mandalapu, Vikas Sharma, Mahendra Shukla, Seema Singh, Nidhi Singh, Santosh Kumar Yadav, Dilip Kumar Tanpula, Surabhi Singh, Jagdamba P Maikhuri, Shubha Shukla, Jawahar Lal, Mohammad I Siddiqi, Gopal Gupta, Vishnu L Sharma
A series of seventeen piperazine derivatives have been synthesized and biologically evaluated for the management of andropause-associated prostatic disorders and depression. Five compounds 16, 19, 20, 21 and 22 significantly inhibited proliferation of androgen-sensitive LNCaP prostatic cell line with EC50 values of 12.4 μM, 15.6 μM, 11.8 μM, 10.4 μM, 12.2 μM respectively and decreased Ca(2+) entry through adrenergic-receptor α1A blocking activity. Anti-androgenic behaviour of compound 19 and 22 was evident by decreased luciferase activity...
May 26, 2017: European Journal of Medicinal Chemistry
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