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leptin and intake

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https://www.readbyqxmd.com/read/29469009/dairy-consumption-and-inflammatory-profile-a-cross-sectional-population-based-study-s%C3%A3-o-paulo-brazil
#1
Tábata Natal Gadotti, Marina Maintinguer Norde, Marcelo Macedo Rogero, Mauro Fisberg, Regina Mara Fisberg, Erica Oki, Lígia Araújo Martini
OBJECTIVES: The aim of this study was to investigate the association between dairy product consumption and plasma inflammatory biomarkers levels among a representative sample of Brazilian adults from São Paulo City. METHODS: Data were acquired from the Health Survey for São Paulo, a cross-sectional population-based study. All individuals 20 to 59 y of age with complete food consumption information (24-h dietary recall and food frequency questionnaire) and blood sample analysis were included (N = 259)...
October 26, 2017: Nutrition
https://www.readbyqxmd.com/read/29467172/amylin-selectively-signals-onto-pomc-neurons-in-the-arcuate-nucleus-of-the-hypothalamus
#2
Thomas A Lutz, Bernd Coester, Lynda Whiting, Ambrose A Dunn-Meynell, Christina N Boyle, Sebastien G Bouret, Barry E Levin, Christelle Le Foll
Amylin phosphorylates ERK (p-ERK) in the area postrema (AP) to reduce eating and synergizes with leptin to phosphorylate STAT3 in the arcuate (ARC) and ventromedial (VMN) hypothalamic nuclei, to reduce food intake and body weight. The current studies assessed potential amylin and amylin-leptin ARC/VMN interactions on ERK signaling and their roles in postnatal hypothalamic pathway development. In amylin knockout (KO) mice, the density of agouti-related protein (AgRP) immunoreactive (IR) fibers in the hypothalamic paraventricular nucleus (PVN) was increased, while the density of α-melanocyte stimulating hormone (αMSH) fibers was decreased...
February 21, 2018: Diabetes
https://www.readbyqxmd.com/read/29466028/analysis-of-the-impact-of-common-polymorphisms-of-the-fto-and-mc4r-genes-with-the-risk-of-severe-obesity-in-saudi-arabian-population
#3
Cyril Cyrus, Mona H Ismail, Shahanas Chathoth, Chittibabu Vatte, Majd Hasen, Amein Al Ali
BACKGROUND: Obesity has reached epidemic proportions worldwide resulting in a serious public health problem. In Saudi Arabia, 28.7% of the population is obese due largely to the adoption of western dietary patterns over the last decade. The Fat-mass and obesity associated (FTO) and melanocortin-4 receptor (MC4R) genes are ubiquitously expressed in the brain and pancreatic islets, and are the main link between the central nervous system and energy homeostasis based on food intake and energy expenditure...
February 21, 2018: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29461665/children-with-cow-s-milk-allergy-following-an-elimination-diet-had-normal-growth-but-relatively-low-plasma-leptin-at-age-two
#4
Ping Dong, Jing-Jing Feng, Dong-Yong Yan, Yu-Jing Lyu, Xiu Xu
AIM: To assess nutrient intake, growth and nutritional status of infants with cow's milk allergy (CMA) who follow a therapeutic elimination diet since the first few months of life. METHODS: Sixty infants younger than 4 months of age with challenge-proven CMA and 60 healthy age-matched children were investigated. Anthropometric and body composition (BC) were assessed up to 24 months. Dietary intake was recorded by the parents for 3 consecutive days before visits at 6, 12, 18 and 24 months...
February 20, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29460468/review-of-the-role-of-leptin-in-the-regulation-of-male-reproductive-function
#5
REVIEW
J Zhang, M Gong
Since discovered in 1994, leptin has been thought to be a pleiotropic hormone that regulates food intake, controls energy balance in the body and influences multiple tissues in the body. Leptin plays an important mediating role in the regulation of neuroendocrine and can transmit the nutritional status signals to the reproductive-related central nervous system. Many studies have shown that leptin may play an important role in the control of reproductive function. Leptin can act on all levels of the hypothalamus-pituitary-gonadal (HPG) axis and may have local effects on the function of testis and spermatogenesis...
February 20, 2018: Andrologia
https://www.readbyqxmd.com/read/29456490/limited-access-to-a-high-fat-diet-alters-endocannabinoid-tone-in-female-rats
#6
Valentina Satta, Maria Scherma, Fabiana Piscitelli, Paolo Usai, M Paola Castelli, Tiziana Bisogno, Walter Fratta, Paola Fadda
Emerging evidence suggest an impaired endocannabinoid activity in the pathophysiology of binge eating disorder (BED). Herein, we investigated whether endocannabinoid tone could be modified as a consequence of dietary-induced binge eating in female rats. For this purpose, brain levels of the endocannabinoids anandamide (AEA) and 2-arachidonoyl glycerol (2-AG), as well as two endocannabinoid-like lipids, oleoylethanolamide (OEA) and palmitoylethanolamide (PEA), were assessed in different brain areas involved in the hedonic feeding (i...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29440390/high-dietary-fat-and-sucrose-results-in-an-extensive-and-time-dependent-deterioration-in-health-of-multiple-physiological-systems-in-mice
#7
James G Burchfield, Melkam A Kebede, Christopher C Meoli, Jacqueline Stöckli, P Tess Whitworth, Amanda L Wright, Nolan J Hoffman, Annabel Y Minard, Xiuquan Ma, James R Krycer, Marin E Nelson, Shi-Xiong Tan, Belinda Yau, Kristen C Thomas, Natalie K Y Wee, Ee-Cheng Khor, Ronaldo F Enriquez, Bryce Vissel, Trevor J Biden, Paul A Baldock, Kyle L Hoehn, James Cantley, Gregory J Cooney, David E James, Daniel J Fazakerley
Obesity is associated with metabolic dysfunction, including insulin resistance and hyperinsulinemia, and with disorders such as cardiovascular disease, osteoporosis, and neurodegeneration. Typically, these pathologies are examined in discrete model systems and with limited temporal resolution, and whether these disorders co-occur is therefore unclear. To address this question, we examined multiple physiological systems in male C57BL/6J mice following prolonged exposure to a high-fat/high-sucrose diet (HFHSD)...
February 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29438540/influence-of-sleep-restriction-on-weight-loss-outcomes-associated-with-caloric-restriction
#8
Xuewen Wang, Joshua R Sparks, Kimberly P Bowyer, Shawn D Youngstedt
Study Objectives: To examine the effects of moderate sleep restriction on body weight, body composition, and metabolic variables in individuals undergoing caloric restriction. Methods: Overweight or obese adults were randomized to an 8-week caloric restriction (CR) regimen alone (n=15) or combined with sleep restriction (CR+SR) (n=21). All participants were instructed to restrict daily calorie intake to 95% of their measured resting metabolic rate. Participants in the CR+SR group were also instructed to reduce time in bed on 5 nights and to sleep ad libitum on the other 2 nights each week...
February 9, 2018: Sleep
https://www.readbyqxmd.com/read/29431471/appetite-suppression-and-altered-food-preferences-coincide-with-changes-in-appetite-mediating-hormones-during-energy-deficit-at-high-altitude-but-are-not-affected-by-protein-intake
#9
J Philip Karl, Renee E Cole, Claire E Berryman, Graham Finlayson, Patrick N Radcliffe, Matthew T Kominsky, Nancy E Murphy, John W Carbone, Jennifer C Rood, Andrew J Young, Stefan M Pasiakos
Karl, J. Philip, Renee E. Cole, Claire E. Berryman, Graham Finlayson, Patrick N. Radcliffe, Matthew T. Kominsky, Nancy E. Murphy, John W. Carbone, Jennifer C. Rood, Andrew J. Young, and Stefan M. Pasiakos. Appetite Suppression and Altered Food Preferences Coincide with Changes in Appetite-Mediating Hormones During Energy Deficit at High Altitude, But Are Not Affected by Protein Intake. High Alt Med Biol. 00:000-000, 2018.-Anorexia and unintentional body weight loss are common during high altitude (HA) sojourn, but underlying mechanisms are not fully characterized, and the impact of dietary macronutrient composition on appetite regulation at HA is unknown...
February 12, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29421542/leptin-levels-and-its-correlation-with-crack-cocaine-user-severity-a-preliminary-study
#10
Mariana Escobar, Juliana Nichterwitz Scherer, Felipe Ornell, Giovana Bristot, Cassia Medino Soares, Luciano Santos Pinto Guimarães, Lísia Von Diemen, Flavio Pechansky
BACKGROUND: Crack-cocaine is an important public health problem in Brazil and worldwide. It is a potent form of cocaine which results in rapid and damaging stimulating effects on the central nervous system through inhibition of the dopamine transporter. Some studies have suggested that both food and drugs - including crack, can act on the same brain reward mechanisms, altering the dopamine pathways that modulate behavioral responses. Our hypothesis was that leptin, a well-known peptide that modulates energy metabolism and appetite, can be used as a biomarker for drug use...
February 5, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29418022/acute-antiobesity-effects-of-intracerebroventricular-11%C3%AE-hsd1-inhibitor-administration-in-diet-induced-obese-mice
#11
Minchul Seo, S K M Azizul Islam, Seong-Su Moon
Hypothalamus is the regulatory center of both appetite and energy balance, and endoplasmic reticulum (ER) stress in the hypothalamus is involved in the pathogenesis of obesity. Recently, inhibition of 11 β hydroxysteroid dehydrogenase type1 (11β-HSD1) was reported to have an anti-obesity effect by reducing fat mass. However, link between the role of 11β-HSD1 in hypothalamus and obesity has yet to be elucidated. In this study, embryonal primary hypothalamic neurons and high fat diet (HFD) fed mice were used to investigate the anorexigenic effects of 11β-HSD1 inhibitors in in vitro and in vivo...
February 8, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29412381/obese-with-higher-fndc5-irisin-levels-have-a-better-metabolic-profile-lower-lipopolysaccharide-levels-and-type-2-diabetes-risk
#12
Ivan Luiz Padilha Bonfante, Mara Patricia Traina Chacon-Mikahil, Diego Trevisan Brunelli, Arthur Fernandes Gáspari, Renata Garbellini Duft, Alexandre Gabarra Oliveira, Tiago Gomes Araujo, Mario Jose Abdalla Saad, Cláudia Regina Cavaglieri
OBJECTIVE: Thus, the aim of this study was to compare if higher or smaller fibronectin type 3 domain-containing protein 5 (FNDC5)/irisin levels are associated with inflammatory and metabolic markers, caloric/macronutrient intake, physical fitness and type 2 diabetes mellitus (T2DM) risk in obese middle-aged men, and also to correlate all variables analyzed with FNDC5/irisin. SUBJECTS AND METHODS: On the basis of a cluster study, middle-aged obese men (IMC: 31.01 ± 1...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29410008/changes-in-eating-behavior-and-plasma-leptin-in-children-with-obesity-participating-in-a-family-centered-lifestyle-intervention
#13
Tamara R Cohen, Tom J Hazell, Catherine A Vanstone, Celia Rodd, Hope A Weiler
The goal of childhood obesity lifestyle interventions are to positively change body composition, however it is unknown if interventions also modulate factors that are related to energy intake. This study aimed to examine changes in eating behaviors and plasma leptin concentrations in overweight and obese children participating in a 1-year family-centered lifestyle intervention. Interventions were based on Canadian diet and physical activity (PA) guidelines. Children were randomized to 1 of 3 groups: Control (Ctrl; no intervention), Standard treatment (StnTx: 2 servings milk and alternatives/day (d), 3x/wk weight-bearing PA), or Modified treatment (ModTx: 4 servings milk and alternatives/day; daily weight-bearing PA)...
February 2, 2018: Appetite
https://www.readbyqxmd.com/read/29407384/regulation-of-compensatory-growth-by-molecular-mechanism-in-labeo-rohita-juveniles-under-different-feeding-regimes
#14
Showkat Ahmad Dar, Prem P Srivastava, Tincy Varghese, Sheikh Irfan Rasool, Garima Anand, Subodh Gupta, P Gireesh-Babu, Gopal Krishna
A study was carried out to assess the regulation of compensatory growth under different restriction feeding regimes in Labeo rohita juveniles by the interaction of various feed intake and growth regulating genes. A 60 day feeding trial was conducted with five treatment groups, Control (3% body weight, bw), T1 (alternate days), T2 (0.5% bw), T3 (1% bw) and T4 (2% bw) and feeding was done for first 30 days of the trial. For next 30 days, all the treatment groups were fed at a rate of 3% bw as in the control group...
January 30, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29405731/apelin-13-increased-food-intake-with-serum-ghrelin-and-leptin-levels-in-male-rats
#15
S Saral, M Alkanat, A Sumer, S Canpolat
In this study, we aimed to explain the role of apelin-13 on body weight, food and water intake with serum leptin, ghrelin, neuropeptid Y (NPY) and peptid YY (PYY) levels in male rat. Thirty-two Sprague-Dawley male rats were used for the study. The rats were injected SP (0.9 %) intraperitoneally (i.p) in the control group and 30 (AP30), 100 (AP100) and 300 (AP300) µg/kg apelin-13 in the study groups, respectively, 10 min before the transition to dark period, for 10 days. During the experimental period, with light and dark periods of food and water intake, body weights were recorded in rats...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29397535/the-leptin-dopamine-and-serotonin-receptors-in-hypothalamic-pomc-neurons-of-normal-and-obese-rodents
#16
Irina V Romanova, Kira V Derkach, Anastasiya L Mikhrina, Ivan B Sukhov, Elena V Mikhailova, Alexander O Shpakov
The pro-opiomelanocortin (POMC)-expressing neurons of the hypothalamic arcuate nucleus (ARC) are involved in the control of food intake and metabolic processes. It is assumed that, in addition to leptin, the activity of these neurons is regulated by serotonin and dopamine, but only subtype 2C serotonin receptors (5-HT2CR) was identified earlier on the POMC-neurons. The aim of this work was a comparative study of the localization and number of leptin receptors (LepR), types 1 and 2 dopamine receptors (D1R, D2R), 5-HT1BR and 5-HT2CR on the POMC-neurons and the expression of the genes encoding them in the ARC of the normal and diet-induced obese (DIO) rodents and the agouti mice (A y /a) with the melanocortin obesity...
February 3, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29395813/ghrelin-concentration-as-an-indicator-of-eating-disorder-risk-in-obese-women
#17
S Iceta, B Julien, K Seyssel, S Lambert-Porcheron, B Segrestin, E Blond, P Cristini, M Laville, E Disse
AIM: Eating disorders (EDs), disordered eating (DE) and obesity are thought to have overlapping aetiological processes. DE in obesity can jeopardize weight-loss results, and acyl ghrelin (AG) is a hormone that stimulates food intake and reward processes. The main study objective was to determine whether higher-than-expected concentrations of AG in common obesity are associated with DE symptoms. METHODS: The study population included 84 women, aged 20-55 years, free of established EDs: 55 were severely obese (OB) and 29 were of normal weight (NW)...
January 27, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29391762/helicobacter-pylori-and-corpus-gastric-pathology-are-associated-with-lower-serum-ghrelin
#18
Paula Mantero, Gonzalo Sebastián Matus, Rodolfo Ernesto Corti, Ana María Cabanne, Gerardo Gabriel Zerbetto de Palma, Liliana Marchesi Olid, María Marta Piskorz, Marcela Beatriz Zubillaga, Mariana Andrea Janjetic, Cinthia Gabriela Goldman
AIM: To evaluate the association of Helicobacter pylori (H. pylori), cagA genotype, and type of gastric pathology with ghrelin, leptin and nutritional status. METHODS: Fasted dyspeptic adults (18-70 years) referred for an upper digestive endoscopy were enrolled in this cross-sectional study. Height and weight were assessed for body mass index (BMI) calculation. A sociodemographic survey was administered and nutrient intake was evaluated with 24 h dietary recalls...
January 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29389606/structural-difference-of-palm-based-medium-and-long-chain-triacylglycerol-mlct-further-reduces-body-fat-accumulation-in-dio-c57bl-6j-mice-when-consumed-in-low-fat-diet-for-a-mid-term-period
#19
Yee-Ying Lee, Teck-Kim Tang, Eng-Tong Phuah, Nur Azwani Abdul Karim, Noorjahan Banu Mohamed Alitheen, Chin-Ping Tan, Intan Shameha Abdul Razak, Oi-Ming Lai
Medium-and-Long Chain Triacylglycerol (MLCT) is a type of structured lipid that is made up of medium chain, MCFA (C8-C12) and long chain, LCFA (C16-C22) fatty acid. Studies claimed that consumption of MLCT has the potential in reducing visceral fat accumulation as compared to long chain triacylglycerol, LCT. This is mainly attributed to the rapid metabolism of MCFA as compared to LCFA. Our study was designed to compare the anti-obesity effects of a enzymatically interesterified MLCT (E-MLCT) with physical blend of palm kernel and palm oil (B-PKOPO) having similar fatty acid composition and a commercial MLCT (C-MLCT) made of rapeseed/soybean oil on Diet Induced Obesity (DIO) C57BL/6J mice for a period of four months in low fat, LF (7%) and high fat, HF (30%) diet...
January 2018: Food Research International
https://www.readbyqxmd.com/read/29384699/catecholaminergic-projections-into-an-interconnected-forebrain-network-control-the-sensitivity-of-male-rats-to-diet-induced-obesity
#20
Shin J Lee, Anne J Jokiaho, Graciela Sanchez-Watts, Alan G Watts
Hindbrain catecholamine neurons convey gut-derived metabolic signals to an interconnected neuronal network in the hypothalamus and adjacent forebrain. They are critical for short-term glycemic control, glucocorticoid and glucoprivic feeding responses, and GLP-1 signaling. Here we investigate whether these pathways also contribute to long-term energy homeostasis by controlling obesogenic sensitivity to a high-fat, high sucrose choice diet (HFSC). We ablated hindbrain-originating catecholaminergic projections by injecting anti-dopamine-β-hydroxylase-conjugated saporin (DSAP) into the paraventricular nucleus of the hypothalamus (PVH) of male rats fed a chow diet for up to 12 weeks or a HFSC for 8 weeks...
January 31, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
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