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leptin and intake

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https://www.readbyqxmd.com/read/29235553/pro-inflammatory-gene-expression-profile-in-obese-adults-with-high-plasma-gip-levels
#1
J Góralska, U Raźny, A Polus, J Stancel-Możwiłło, M Chojnacka, A Gruca, A Zdzienicka, A Dembińska-Kieć, B Kieć-Wilk, B Solnica, M Malczewska-Malec
BACKGROUND: GIP provides a novel link between the immune system and the gut, although results from different experimental and observational studies are contradictory, ranging from anti-inflammatory, through neutral to pro-inflammatory action of GIP. Thus, the aim of this study was to analyze inflammatory pathways on the level of gene expression and circulating inflammatory markers in relation to plasma GIP level. SUBJECTS/METHODS: The study included 128 obese adults...
December 13, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29233862/prolactin-releasing-peptide-improved-leptin-hypothalamic-signaling-in-obese-mice
#2
Martina Holubova, Lucie Hrubá, Barbora Neprašová, Zuzana Majercikova, Zdena Lacinova, Jaroslav Kunes, Lenka Maletinska, Blanka Zelezna
The situation following anti-obesity drug termination is rarely investigated, even though a decrease in body weight needs to be sustained. Therefore, this study examined the impact of twice-daily peripheral administration of 5 mg/kg [N-palm-γGlu-Lys11] prolactin-releasing peptide 31 (palm11-PrRP31) in mice with diet-induced obesity (DIO from consuming a high-fat diet) after 28 days of treatment (palm11-PrRP31 group) and after 14 days of peptide treatment followed by 14 days of discontinuation (palm11-PrRP31+saline group)...
December 12, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29224092/sex-differences-in-leptin-control-of-cardiovascular-function-in-health-and-metabolic-diseases
#3
Eric J Belin de Chantemèle
Leptin, the adipocyte-derived hormone identified in 1994 for its major role in the control of satiety and body weight regulation, is an adipokine secreted in a sex-specific manner. Although it has clearly been established that females secrete three to four times more leptin than males and that this sexual dimorphism in leptin secretion is exacerbated with overweight and obesity, the origin and the physiological consequences of this sexual dimorphism remain ill-defined. The adipose tissue is the major site of leptin secretion; however, leptin receptors are ubiquitously expressed, conferring to leptin, and indirectly to the adipose tissue, a potential role in the control of numerous physiological functions...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29219061/effect-of-conjugated-linoleic-acid-supplementation-on-serum-leptin-concentration-a-systematic-review-and-meta-analysis
#4
Fahimeh Haghighatdoost, Mitra Hariri
BACKGROUND: There are controversies regarding the effect of conjugated linoleic acid (CLA) on serum leptin. OBJECTIVE: To conduct a meta-analysis of randomized controlled trials (RCTs) to assess the effect of CLA on serum leptin concentrations. METHOD: Databases such as Ovid, PubMed/Medline, SCOPUS, Google Scholar, and ISI databases up to January 2017 were searched. The searches included RCTs conducted among human adults, and studies on the effect of conjugated linoleic acid on serum leptin concentrations as outcome variables...
December 7, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29216634/lysine-restriction-affects-feed-intake-and-amino-acid-metabolism-via-gut-microbiome-in-piglets
#5
Jie Yin, Hui Han, Yuying Li, Zhaojin Liu, Yurong Zhao, Rejun Fang, Xingguo Huang, Jie Zheng, Wenkai Ren, Fei Wu, Gang Liu, Xin Wu, Kai Wang, Liping Sun, Chunyong Li, Tiejun Li, Yulong Yin
BACKGROUND/AIMS: Our previous reports suggested that dietary supplementation with lysine influenced intestinal absorption and metabolism of amino acids. In this study, we further investigated the effect of lysine restriction (30%) on feed intake and we also tested the hypothesis that gut microbiome contributed to the potential mechanism of lysine restriction-mediated feeding behavior. Here, we profiled gut microbial communities by sequencing 16S ribosomal ribonucleic acid (rRNA) genes from gut samples as well as growth performance, serum hormones, and intestinal lysine transport in a piglet model...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29211750/chow-fed-uc-davis-strain-female-lepr-fatty-zucker-rats-exhibit-mild-glucose-intolerance-hypertriglyceridemia-and-increased-urine-volume-all-reduced-by-a-brown-norway-strain-chromosome-1-congenic-donor-region
#6
Craig H Warden, Ahmed Bettaieb, Esther Min, Janis S Fisler, Fawaz G Haj, Judith S Stern
Our objective is to identify genes that influence the development of any phenotypes of type 2 diabetes (T2D) or kidney disease in obese animals. We use the reproductively isolated UC Davis fatty Zucker strain rat model in which the defective chromosome 4 leptin receptor (LeprfaSte/faSte) results in fatty obesity. We previously produced a congenic strain with the distal half of chromosome 1 from the Brown Norway strain (BN) on a Zucker (ZUC) background (BN.ZUC-D1Rat183-D1Rat90). Previously published studies in males showed that the BN congenic donor region protects from some phenotypes of renal dysfunction and T2D...
2017: PloS One
https://www.readbyqxmd.com/read/29207625/stanniocalcin2-acts-as-an-anorectic-factor-through-activation-of-stat3-pathway
#7
Yang Jiao, Jiejie Zhao, Guojun Shi, Xing Liu, Xuelian Xiong, Xiaoying Li, Huijie Zhang, Qinyun Ma, Yan Lu
The regulation of food intake and body weight has been hotly investigated. In the present study, we show that stanniocalcin2 (STC2), a cytokine ubiquitously expressed and especially upregulated in many types of human cancers, has a regulatory role in food intake and weight loss. Systemic treatment of C57BL/6 mice with recombinant STC2 protein resulted in decreased food intake and body weight, whereas energy expenditure was not affected. Similarly, STC2 treatment also induced anorexia in hyperphagic leptin-deficient mice, leading to a significant reduction in body weight and improvement of blood glucose levels...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207134/novel-herbal-medicine-la16001-ameliorates-cisplatin-induced-anorexia
#8
Sang-Mi Woo, Kang Min Lee, Gyu Ri Lee, Ji Youn Park, Hee Jae Lee, Hyo-Jung Bahn, Hyun Seok Yoon, Jem Yung Kim, Young Cheol Shin, Sung-Gook Cho, Seong-Gyu Ko
Chemotherapy frequently causes anorexia in cancer patients, which has been associated with poor disease prognosis. Several therapeutic strategies for the treatment of chemotherapy‑induced anorexia are available; however, their adverse effects limit their clinical use. Herbal medicines have a long history of use for the treatment of various diseases, including cancer, and recent research has demonstrated their safety and efficacy. In the present study, combinations of herbal medicines were designed based on traditional Korean medicine, and their effects were investigated on chemotherapy‑induced anorexia...
November 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29206867/gnb3-overexpression-causes-obesity-and-metabolic-syndrome
#9
Alev Cagla Ozdemir, Grace M Wynn, Aimee Vester, M Neale Weitzmann, Gretchen N Neigh, Shanthi Srinivasan, M Katharine Rudd
The G-protein beta subunit 3 (GNB3) gene has been implicated in obesity risk; however, the molecular mechanism of GNB3-related disease is unknown. GNB3 duplication is responsible for a syndromic form of childhood obesity, and an activating DNA sequence variant (C825T) in GNB3 is also associated with obesity. To test the hypothesis that GNB3 overexpression causes obesity, we created bacterial artificial chromosome (BAC) transgenic mice that carry an extra copy of the human GNB3 risk allele. Here we show that GNB3-T/+ mice have increased adiposity, but not greater food intake or a defect in satiety...
2017: PloS One
https://www.readbyqxmd.com/read/29204137/microbial-mechanistic-insight-into-the-role-of-inulin-in-improving-maternal-health-in-a-pregnant-sow-model
#10
Pan Zhou, Yang Zhao, Pan Zhang, Yan Li, Taotao Gui, Jun Wang, Chao Jin, Lianqiang Che, Jian Li, Yan Lin, Shengyu Xu, Bin Feng, Zhengfeng Fang, De Wu
General consumption of "western diet" characterized by high refined carbohydrates, fat and energy intake has resulted in a global obesity epidemics and related metabolic disturbance even for pregnant women. Pregnancy process is accompanied by substantial hormonal, metabolic and immunological changes during which gut microbiota is also remarkably remodeled. Dietary fiber has been demonstrated to have a striking role in shifting the microbial composition so as to improve host metabolism and health in non-pregnant individuals...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29195999/the-effect-of-raisins-on-biomarkers-of-endothelial-function-and-oxidant-damage-an-open-label-and-randomized-controlled-intervention
#11
Panagiotis T Kanellos, Andriana C Kaliora, Athanasios D Protogerou, Nikolaos Tentolouris, Despina N Perrea, Vaios T Karathanos
Based on the existing data in grapes and wine, the aim of the present study was to investigate the probability that raisins improve clinical features and markers of oxidative stress, inflammation and arterial function in healthy smokers. Thirty-six apparently healthy smokers were recruited to an open-label and randomized, controlled, 4-week prospective intervention. All participants were reported to consume less than the recommended amount of five servings fruits and vegetables daily. Participants in the intervention were instructed to consume raisins equal to five fruit servings (90g/d)...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29193738/cooperative-role-of-the-glp-1-receptor-and-%C3%AE-3-adrenergic-mediated-signaling-on-fat-mass-reduction-through-the-down-regulation-of-pka-akt-ampk-signaling-in-the-adipose-tissue-and-muscle-of-rats
#12
Juan Decara, Patricia Rivera, Sergio Arrabal, Antonio Vargas, Antonia Serrano, Francisco Javier Pavón, Carlos Dieguez, Rubén Nogueiras, Fernando Rodríguez de Fonseca, Juan Suárez
AIM: To explore the cooperation of GLP-1 receptor and β3-adrenergic receptor-mediated signaling in the control of fat mass/feeding behavior by studying the effects of a combined therapy composed of the GLP-1R agonist liraglutide and the β3-AR agonist CL316243. METHODS: The study included the analysis of key mechanisms regulating lipid/cholesterol metabolism, and thermogenesis in brown (BAT) and epididymal white (eWAT) adipose tissues, abdominal muscle and liver of male rats...
November 28, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/29190720/intramyocellular-triacylglycerol-accumulation-across-weight-loss-strategies-sub-study-of-the-central-trial
#13
Yftach Gepner, Ilan Shelef, Dan Schwarzfuchs, Noa Cohen, Nitzan Bril, Michal Rein, Gal Tsaban, Hila Zelicha, Anat Yaskolka Meir, Lilac Tene, Benjamin Sarusy, Philip Rosen, Jay R Hoffman, Jeffrey R Stout, Joachim Thiery, Uta Ceglarek, Michael Stumvoll, Matthias Blüher, Meir J Stampfer, Iris Shai
BACKGROUND: Intramyocellular triacylglycerol (IMTG) is utilized as metabolic fuel during exercise and is linked to insulin resistance, but the long-term effect of weight loss strategies on IMTG among participants with abdominal fat, remain unclear. METHODS: In an 18-month trial, sedentary participants with abdominal fat/dyslipidemia were randomized to either a low-fat (LF) or Mediterranean/low-carbohydrate (MED/LC) diet (including 28g·day-1 of walnuts). After 6-months, the participants were re-randomized to moderate intense physical activity (PA+) or non-physical activity (PA-)...
2017: PloS One
https://www.readbyqxmd.com/read/29190687/leptin-reverses-hyperglycemia-and-hyperphagia-in-insulin-deficient-diabetic-rats-by-pituitary-independent-central-nervous-system-actions
#14
Alexandre A da Silva, John E Hall, Jussara M do Carmo
The hypothalamic-pituitary-adrenal (HPA) axis has been postulated to play a major role in mediating the antidiabetic effects of leptin. We tested if the pituitary is essential for the chronic central nervous system mediated actions of leptin on metabolic and cardiovascular function in insulin-dependent diabetic and non-diabetic rats. Male 12-week-old hypophysectomized Sprague-Dawley rats (Hypo, n = 5) were instrumented with telemetry probes for determination of mean arterial pressure (MAP) and heart rate (HR) 24-hrs/day and an intracerebroventricular (ICV) cannula was placed into the brain lateral ventricle for continuous leptin infusion...
2017: PloS One
https://www.readbyqxmd.com/read/29186387/resveratrol-intake-during-pregnancy-and-lactation-modulates-the-early-metabolic-effects-of-maternal-nutrition-differently-in-male-and-female-offspring
#15
Purificación Ros, Francisca Díaz, Alejandra Freire-Regatillo, Pilar Argente-Arizón, Vicente Barrios, Jesús Argente, Julie A Chowen
Poor maternal nutrition can have detrimental long-term consequences on energy homeostasis in the offspring. Resveratrol exerts anti-oxidant and anti-obesity actions, but its impact during development remains largely unknown. We hypothesized that resveratrol intake during pregnancy and lactation could improve the effects of poor maternal nutrition on offspring metabolism. Wistar rats received a low-fat diet (LFD: 10.2% Kcal from fat) or high fat diet (HFD: 61.6% Kcal from fat), with half of each group receiving resveratrol (+R) in their drinking water (50 mg/L) during pregnancy and lactation...
November 24, 2017: Endocrinology
https://www.readbyqxmd.com/read/29180021/insulin-resistance-in-3t3-l1-adipocytes-by-tnf-%C3%AE-is-improved-by-punicic-acid-through-upregulation-of-insulin-signalling-pathway-and-endocrine-function-and-downregulation-of-proinflammatory-cytokines
#16
S S Anusree, G Sindhu, M R Preetha Rani, K G Raghu
Insulin resistance (IR) has become a major threat to public health due to its role in metabolic syndrome. Inflammation associated with IR is an interesting area of biomedical researchers in recent years and is expected to affect insulin signalling pathway via downregulating glucose transporters. In the present study, we evaluate the potential of punicic acid (PA), a nutraceutical found in pomegranate seed oil, against TNF-α induced alteration in 3T3-L1 adipocytes on glucose metabolism, endocrine function and inflammation...
November 24, 2017: Biochimie
https://www.readbyqxmd.com/read/29175578/exposure-to-permethrin-promotes-high-fat-diet-induced-weight-gain-and-insulin-resistance-in-male-c57bl-6j-mice
#17
Xiao Xiao, Quancai Sun, Yoo Kim, Szu-Hao Yang, Weipeng Qi, Daeyoung Kim, Kyong Sup Yoon, John M Clark, Yeonhwa Park
Permethrin is a pyrethroid pesticide that was previously reported to promote fat accumulation and insulin resistance in vitro. A recent study in female mice also found that permethrin could promote high fat-induced insulin resistance. The effects of permethrin on glucose and lipid metabolisms in male mice, however, remain unknown. The purpose of this study was to investigate the effects and interactions of permethrin exposure (50, 500, and 5000 μg/kg body weight/day) and dietary fat (low fat, 4% w/w; high fat, 20% w/w) on development of obesity and insulin resistance in male C57BL/6J mice...
November 23, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29175182/impact-of-diesel-exhaust-exposure-on-the-liver-of-mice-fed-on-omega-3-polyunsaturated-fatty-acids-deficient-diet
#18
Masakazu Umezawa, Masayuki Nakamura, Ashraf A El-Ghoneimy, Atsuto Onoda, Hazem M Shaheen, Hiroshi Hori, Yusuke Shinkai, Yasser S El-Sayed, Ali H El-Far, Ken Takeda
Exposure to diesel exhaust (DE) exacerbates non-alcoholic fatty liver disease, and may systemically affect lipid metabolism. Omega-3 polyunsaturated fatty acids (n-3 PUFA) have anti-inflammatory activity and suppresses hepatic triacylglycerol accumulation, but many daily diets are deficient in this nutrient. Therefore, the effect of DE exposure in mice fed n-3 PUFA-deficient diet was investigated. Mice were fed control chow or n-3 PUFA-deficient diet for 4 weeks, then exposed to clean air or DE by inhalation for further 4 weeks...
November 21, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29173690/omega-3-fatty-acids-inflammatory-status-and-biochemical-markers-of-patients-with-systemic-lupus-erythematosus-a-pilot-study
#19
Mariane Curado Borges, Fabiana de Miranda Moura Dos Santos, Rosa Weiss Telles, Marcus Vinícius Melo de Andrade, Maria Isabel Toulson Davisson Correia, Cristina Costa Duarte Lanna
BACKGROUND: Studies have shown that omega-3 fatty acids reduce the concentrations of eicosanoids, cytokines, chemokines, C-reactive protein (CRP) and other inflammatory mediators. OBJECTIVE: To investigate the effects of omega-3 fatty acids on circulating levels of inflammatory mediators and biochemical markers in women with systemic lupus erythematosus (SLE). METHODS: Experimental clinical study (clinical trial: NCT02524795); 49 women with SLE (ACR1982/1997) were randomized: 22 to the omega-3 group (daily intake of 1080mg EPA+200mg DHA, for 12 weeks) and 27 to the control group...
November 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29167577/association-of-maternal-breast-milk-and-serum-levels-of-macronutrients-hormones-and-maternal-body-composition-with-infant-s-body-weight
#20
Adeleh Khodabakhshi, Hassan Mehrad-Majd, Farhad Vahid, Mohammad Safarian
BACKGROUND/OBJECTIVES: This study was aimed to investigate the association of maternal serum and breast-milk levels of macronutrients, hormones, growth factors, and maternal body composition with infant's body weight. SUBJECTS/METHODS: Eighty mother-infant pairs comprised 40 with overweight or obese infant and 40 with normal-weight infant were enrolled in this study. The level of ghrelin, Leptin, adiponectin, EGF, and IGF1 in plasma and breast milk were assessed...
November 23, 2017: European Journal of Clinical Nutrition
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