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https://www.readbyqxmd.com/read/28568891/oncolytic-maraba-virus-mg1-as-a-treatment-for-sarcoma
#1
Fabrice Le Boeuf, Mohammed Selman, Hwan Hee Son, Anabel Bergeron, Andrew Chen, Jovian Tsang, Derek Butterwick, Rozanne Arulanandam, Nicole E Forbes, Fanny Tzelepis, John C Bell, Joel Werier, Hesham Abdelbary, Jean-Simon Diallo
The poor prognosis of patients with advanced bone and soft-tissue sarcoma has not changed in the past several decades, highlighting the necessity for new therapeutic approaches. Immunotherapies, including oncolytic viral (OV) therapy, have shown great promise in a number of clinical trials for a variety of tumor types. However, the effective application of OV in treating sarcoma still remains to be demonstrated. Although few pre-clinical studies using distinct OVs have been performed and demonstrated therapeutic benefit in sarcoma models, a side-by-side comparison of clinically relevant OV platforms has not been performed...
May 31, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28159747/nk-cell-recruitment-is-necessary-for-eradication-of-peritoneal-carcinomatosis-with-an-il12-expressing-maraba-virus-cellular-vaccine
#2
Almohanad A Alkayyal, Lee-Hwa Tai, Michael A Kennedy, Christiano Tanese de Souza, Jiqing Zhang, Charles Lefebvre, Shalini Sahi, Abhirami A Ananth, Ahmad Bakur Mahmoud, Andrew P Makrigiannis, Greg O Cron, Blair Macdonald, E Celia Marginean, David F Stojdl, John C Bell, Rebecca C Auer
Despite improvements in chemotherapy and radical surgical debulking, peritoneal carcinomatosis (PC) remains among the most common causes of death from abdominal cancers. Immunotherapies have been effective for selected solid malignancies, but their potential in PC has been little explored. Here, we report that intraperitoneal injection of an infected cell vaccine (ICV), consisting of autologous tumor cells infected ex vivo with an oncolytic Maraba MG1 virus expressing IL12, promotes the migration of activated natural killer (NK) cells to the peritoneal cavity in response to the secretion of IFNγ-induced protein-10 (IP-10) from dendritic cells...
February 3, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/27909702/complement-inhibition-enables-tumor-delivery-of-lcmv-glycoprotein-pseudotyped-viruses-in-the-presence-of-antiviral-antibodies
#3
Laura Evgin, Carolina S Ilkow, Marie-Claude Bourgeois-Daigneault, Christiano Tanese de Souza, Lawton Stubbert, Michael S Huh, Victoria A Jennings, Monique Marguerie, Sergio A Acuna, Brian A Keller, Charles Lefebvre, Theresa Falls, Fabrice Le Boeuf, Rebecca A Auer, John D Lambris, J Andrea McCart, David F Stojdl, John C Bell
The systemic delivery of therapeutic viruses, such as oncolytic viruses or vaccines, is limited by the generation of neutralizing antibodies. While pseudotyping of rhabdoviruses with the lymphocytic choriomeningitis virus glycoprotein has previously allowed for multiple rounds of delivery in mice, this strategy has not translated to other animal models. For the first time, we provide experimental evidence that antibodies generated against the lymphocytic choriomeningitis virus glycoprotein mediate robust complement-dependent viral neutralization via activation of the classical pathway...
2016: Molecular Therapy Oncolytics
https://www.readbyqxmd.com/read/27503504/combination-of-paclitaxel-and-mg1-oncolytic-virus-as-a-successful-strategy-for-breast-cancer-treatment
#4
Marie-Claude Bourgeois-Daigneault, Lauren Elizabeth St-Germain, Dominic Guy Roy, Adrian Pelin, Amelia Sadie Aitken, Rozanne Arulanandam, Theresa Falls, Vanessa Garcia, Jean-Simon Diallo, John Cameron Bell
BACKGROUND: Breast cancer is the most common malignant disease amongst Western women. The lack of treatment options for patients with chemotherapy-resistant or recurrent cancers is pushing the field toward the rapid development of novel therapies. The use of oncolytic viruses is a promising approach for the treatment of disseminated diseases like breast cancer, with the first candidate recently approved by the Food and Drug Administration for use in patients. In this report, we demonstrate the compatibility of oncolytic virotherapy and chemotherapy using various murine breast cancer models...
August 8, 2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/24695102/maraba-mg1-virus-enhances-natural-killer-cell-function-via-conventional-dendritic-cells-to-reduce-postoperative-metastatic-disease
#5
Jiqing Zhang, Lee-Hwa Tai, Carolina S Ilkow, Almohanad A Alkayyal, Abhirami A Ananth, Christiano Tanese de Souza, Jiahu Wang, Shalini Sahi, Lundi Ly, Charles Lefebvre, Theresa J Falls, Kyle B Stephenson, Ahmad B Mahmoud, Andrew P Makrigiannis, Brian D Lichty, John C Bell, David F Stojdl, Rebecca C Auer
This study characterizes the ability of novel oncolytic rhabdoviruses (Maraba MG1) to boost natural killer (NK) cell activity. Our results demonstrate that MG1 activates NK cells via direct infection and maturation of conventional dendritic cells. Using NK depletion and conventional dendritic cells ablation studies in vivo, we established that both are required for MG1 efficacy. We further explored the efficacy of attenuated MG1 (nonreplicating MG1-UV(2min) and single-cycle replicating MG1-Gless) and demonstrated that these viruses activate conventional dendritic cells, although to a lesser extent than live MG1...
July 2014: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/24648451/vesiculovirus-neutralization-by-natural-igm-and-complement
#6
Mulu Z Tesfay, Arun Ammayappan, Mark J Federspiel, Glen N Barber, David Stojdl, Kah-Whye Peng, Stephen J Russell
UNLABELLED: Because of its very low human seroprevalence, vesicular stomatitis virus (VSV) has promise as a systemic oncolytic agent for human cancer therapy. However, as demonstrated in this report, the VSV infectious titer drops by 4 log units during the first hour of exposure to nonimmune human serum. This neutralization occurs relatively slowly and is mediated by the concerted actions of natural IgM and complement. Maraba virus, whose G protein is about 80% homologous to that of VSV, is relatively resistant to the neutralizing activity of nonimmune human serum...
June 2014: Journal of Virology
https://www.readbyqxmd.com/read/24322333/maraba-virus-as-a-potent-oncolytic-vaccine-vector
#7
Jonathan G Pol, Liang Zhang, Byram W Bridle, Kyle B Stephenson, Julien Rességuier, Stephen Hanson, Lan Chen, Natasha Kazdhan, Jonathan L Bramson, David F Stojdl, Yonghong Wan, Brian D Lichty
The rhabdovirus Maraba has recently been characterized as a potent oncolytic virus. In the present study, we engineered an attenuated Maraba strain, defined as MG1, to express a melanoma-associated tumor antigen. Its ability to mount an antitumor immunity was evaluated in tumor-free and melanoma tumor-bearing mice. Alone, the MG1 vaccine appeared insufficient to prime detectable adaptive immunity against the tumor antigen. However, when used as a boosting vector in a heterologous prime-boost regimen, MG1 vaccine rapidly generated strong antigen-specific T-cell immune responses...
February 2014: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/21830071/genetic-and-antigenic-relationships-of-vesicular-stomatitis-viruses-from-south-america
#8
Steven J Pauszek, Jose Del C Barrera, Tony Goldberg, Rossana Allende, Luis L Rodriguez
Vesicular stomatitis (VS) viruses have been classified into two serotypes: New Jersey (VSNJV) and Indiana (VSIV). Here, we have characterized field isolates causing vesicular stomatitis in Brazil and Argentina over a 35-year span. Cluster analysis based on either serological relatedness, as inferred from virus neutralization and complement fixation assays, or nucleotide sequences of two separate genes (phosphoprotein or glycoprotein) grouped the field isolates into two distinct monophyletic groups within the Indiana serogroup...
November 2011: Archives of Virology
https://www.readbyqxmd.com/read/21560181/non-human-viruses-developed-as-therapeutic-agent-for-use-in-humans
#9
REVIEW
Danijela Koppers-Lalic, Rob C Hoeben
Viruses usually infect a restricted set of host species, and only in rare cases does productive infection occur outside the natural host range. Infection of a new host species can manifest as a distinct disease. In this respect, the use of non-human viruses in clinical therapy may be a cause for concern. It could provide the opportunity for the viruses to adapt to the new host and be transferred to the recipient's relatives or medical caretakers, or even to the normal host species. Such environmental impact is evidently undesirable...
July 2011: Reviews in Medical Virology
https://www.readbyqxmd.com/read/20551913/identification-of-genetically-modified-maraba-virus-as-an-oncolytic-rhabdovirus
#10
Jan Brun, Dan McManus, Charles Lefebvre, Kang Hu, Theresa Falls, Harold Atkins, John C Bell, J Andrea McCart, Douglas Mahoney, David F Stojdl
To expand our current array of safe and potent oncolytic viruses, we screened a variety of wild-type (WT) rhabdoviruses against a panel of tumor cell lines. Our screen identified a number of viruses with varying degrees of killing activity. Maraba virus was the most potent of these strains. We built a recombinant system for the Maraba virus platform, engineered a series of attenuating mutations to expand its therapeutic index, and tested their potency in vitro and in vivo. A double mutant (MG1) strain containing both G protein (Q242R) and M protein (L123W) mutations attenuated Maraba virus in normal diploid cell lines, yet appeared to be hypervirulent in cancer cells...
August 2010: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/6091472/carajas-and-maraba-viruses-two-new-vesiculoviruses-isolated-from-phlebotomine-sand-flies-in-brazil
#11
A P Travassos da Rosa, R B Tesh, J F Travassos da Rosa, J P Herve, A J Main
Two new rhabdoviruses, designated Carajas and Maraba, are described. Both were isolated from phlebotomine sand flies (Lutzomyia spp.) collected in the Amazon basin of Brazil. One recovery of Carajas virus was made from male sand flies. By complement-fixation and neutralization tests both agents were shown to be members of the vesicular stomatitis virus (VSV) serogroup (genus Vesiculovirus). The pathogenicity of the two viruses in mice and Vero cells is similar to that of VSV-Indiana and VSV-New Jersey. Both Carajas and Maraba viruses replicated in Lutzomyia longipalpis following intrathoracic inoculation, and both agents were transovarially transmitted in this sand fly species...
September 1984: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/3034087/natural-infection-of-humans-animals-and-phlebotomine-sand-flies-with-the-alagoas-serotype-of-vesicular-stomatitis-virus-in-colombia
#12
R B Tesh, J Boshell, G B Modi, A Morales, D G Young, A Corredor, C Ferro de Carrasquilla, C de Rodriguez, L L Walters, M O Gaitan
Five isolations of the Alagoas serotype of vesicular stomatitis virus (Rhabdoviridae: Vesiculovirus) were made from naturally infected phlebotomine sand flies (Lutzomyia spp.) collected in Colombia. These are the first isolations of Alagoas virus from an arthropod. Replication of the virus occurred in laboratory-reared sand flies (Lutzomyia longipalpis) after inoculation. Bite and transovarial transmission of the virus was also demonstrated in experimentally infected sand flies. Alagoas virus neutralizing antibodies were found in sera of humans and animals living near the insect collection site; antibody rates among human residents of two nearby towns were 63% and 83%, respectively...
May 1987: American Journal of Tropical Medicine and Hygiene
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