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JOURNAL ARTICLE
Tingwei Quan, Qi Su, Yu Luo, Xin Su, Qiuxuan Chen, Jingjun Yang, Hongzhen Tang
BACKGROUND: Although increasing evidence has revealed the efficacy of acupuncture in obesity/overweight, actual improvement in metabolism in children and adolescents is unclear. Therefore, we conducted a meta-analysis to evaluate this correlation. METHODS: A comprehensive search was conducted using multiple databases, including Medline, Cochrane, Embase, Web of Science, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Chinese Scientific Journal Database, and Wan-fang Data, to identify relevant randomized controlled trials published before February 1, 2023...
October 6, 2023: Medicine (Baltimore)
#22
REVIEW
Konstantina Dragoumani, Andreas Troumbis, Flora Bacopoulou, George Chrousos
There have been numerous attempts to establish a correlation between obesity and stress, inflammatory, and dysmetabolism biomarkers in children and adolescents. Here, we performed a meta-analysis of existing studies to shed light on the elusive correlations of childhood and adolescent obesity with physiological indicators of stress, inflammation, and metabolism before and after lifestyle interventions. Observational studies, meta-analyses, narrative and systematic reviews were excluded. From a total of 53 articles, 11 were selected according to specific criteria...
August 28, 2023: Journal of Personalized Medicine
#23
JOURNAL ARTICLE
Joicy Karla Grangeiro Pereira, Rubia Cartaxo Squizato DE Moraes, Ana Lydia Sawaya, José Luiz de Brito Alves, Andrea Filgueiras, Maria do Carmo Franco, Vinicius José Baccin Martins
The coexistence of stunting and excess weight in the same individual is defined as a double burden of malnutrition (DBM) and is associated with noncommunicable diseases. In this study, we evaluated the impact of DBM on adipokine concentrations and metabolic profiles in children compared with weight excess alone. Children were allocated to the weight excess group (n=23) [height-for-age (HAZ)>0.0, <2.0 Z score, and body mass index-for-age (BMI/I)>1.0 Z score] or DBM (n=22) group [HAZ<-1.0 Z score (including mild stunting), and BMI/I>1...
September 15, 2023: Applied Physiology Nutrition and Metabolism
#24
JOURNAL ARTICLE
Katarzyna Jakubek-Kipa, Sabina Galiniak, Katarzyna Łagowska, Izabela Krupa, Aleksandra Ludwin, Jacek Tabarkiewicz, Artur Mazur
INTRODUCTION: The purpose of our study was tomeasure the level of leptin and biologically active leptin (bioLEP) in children with type 1 diabetes, depending on the duration of diabetes and its degree of metabolic control. METHODS: The study included 94 children (58 boys and 36 girls). In a group of children with diabetes, 40 patients were newly diagnosed with type 1 diabetes, 40 children who have diabetes for more than a year (20 with good metabolic control and 20 with poor metabolic control)...
2023: Frontiers in Endocrinology
#25
JOURNAL ARTICLE
Julián Mier-Mota, Jesús G Ponce-González, Alejandro Perez-Bey, Verónica Cabanas-Sánchez, Oscar Veiga-Núñez, Catalina Santiago-Dorrego, Félix Gómez-Gallego, José Castro-Piñero
The role of polymorphism rs9939609 of the FTO gene has been related with fat mass and cardiovascular risk in adults, but it remains unclear in children and adolescents. Hence, the main aim of this study was to determine the FTO polymorphism effects on body composition, cardiorespiratory fitness (CRF), physical activity (PA), inflammatory markers, and cardiovascular risk both in cross-sectional analysis and after two-years of follow-up in children and adolescents. A total of 2129 participants were included in this study...
August 30, 2023: Scandinavian Journal of Medicine & Science in Sports
#26
JOURNAL ARTICLE
Giuseppina Rosaria Umano, Grazia Cirillo, Gianmaria Sanchez, Giulia Rondinelli, Maria Vittoria Foderini, Serena Ferrara, Anna Di Sessa, Pierluigi Marzuillo, Alfonso Papparella, Nicola Santoro, Emanuele Miraglia Del Giudice
OBJECTIVE: Leptin plays a key role in the regulation of body weight and other endocrine systems. Recently, impairment of leptin gene transcription due to genetic variations in a long noncoding RNA (lncOb) has been described. This retrospective study aims to characterize the clinical and metabolic phenotype of children and adolescents with obesity who were homozygous for the lncOb rs10487505 leptin lowering allele. METHODS: Enrolled children underwent an anthropometrical evaluation, biochemical assessment, and genotyping for lncOb rs10487505...
August 7, 2023: Obesity
#27
REVIEW
Ya Li, Tonghua Liu, Lingling Qin, Lili Wu
BACKGROUND: This paper aimed to examine the effects of probiotics on eight factors in overweight or obese children by meta-analysis, namely, body mass index (BMI), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), adiponectin, leptin and tumor necrosis factor-α (TNF-α) and summarize the mechanisms of action of probiotics based on the existing researches. METHODS: Six databases (PubMed, Web of Science, Embase, Cochrane Library, SinoMed and CNKI) were searched until March 2023...
August 4, 2023: Journal of Translational Medicine
#28
JOURNAL ARTICLE
Mayara Vieira Queiroz De Paula, Maude Grant, Julie Lanigan, Atul Singhal
BACKGROUND: Possible mechanisms behind the association of breastfeeding with a lower risk of later obesity are unknown but one possibility is the unique composition of human milk. Here, we systematically reviewed the evidence linking breast-milk macronutrient and hormonal composition with later obesity. METHODS: We searched 7 databases for studies that included infants predominantly breast-fed for the first 3 months and which analysed associations between a measure of breast-milk composition and later (> 6 months) measures of obesity or body composition...
July 20, 2023: BMC Nutrition
#29
JOURNAL ARTICLE
O Abawi, R J Wahab, L Kleinendorst, L A Blankers, A E Brandsma, E F C van Rossum, B van der Voorn, M M van Haelst, R Gaillard, E L T van den Akker
OBJECTIVE: To assess BMI trajectories of children with genetic obesity in order to identify optimal early age of onset of obesity (AoO) cut-offs for genetic screening. STUDY DESIGN: T his longitudinal, observational study included growth measurements from birth onwards of children with non-syndromic and syndromic genetic obesity and control children with obesity from a population-based cohort. Diagnostic performance of AoO was evaluated. RESULTS: We describe BMI trajectories of 62 children with genetic obesity (29 non-syndromic, 33 syndromic) and 298 controls...
July 18, 2023: Journal of Pediatrics
#30
JOURNAL ARTICLE
Hae-Jin Ko, Sarah Woo, Junhee Han, Yoon Myung Kim, Hyun Jung Lim, Min-Jeong Kim, Yong Soon Park, Kyung Hee Park
INTRODUCTION: We aimed to evaluate the relationships between hepatic steatosis and various indices of obesity, and to identify the most useful index for the prediction of hepatic steatosis in children and adolescents with obesity. METHODS: A total of 226 children and adolescents with a mean body mass index (BMI) z-score of 2.65 and a mean age of 11.4 years were subjected to anthropometric and body composition measurements, laboratory testing, abdominal fat mass assessment, and hepatic fat accumulation by magnetic resonance imaging-derived proton density fat fraction (MRI-PDFF)...
June 17, 2023: Obesity Research & Clinical Practice
#31
JOURNAL ARTICLE
Junia N de Brito, Mark A Pereira, Aaron S Kelly, Darin J Erickson, Nancy E Sherwood, Susan M Mason, Katie A Loth, Simone A French, Nicholas G Evanoff, Donald R Dengel, Alicia S Kunin-Batson
Background: This study examined the associations between BMI trajectories and emerging cardiometabolic risk (CMR) in children living in low-income and racially and ethnically diverse households in the United States. Methods: Data were drawn from NET-Works randomized intervention trial and NET-Works 2 prospective follow-up study ( N = 338). BMI was measured across 6 follow-up visits and biomarkers of cardiometabolic risk (CMR) at the sixth visit. Group-based trajectory modeling identified child BMI trajectories...
June 15, 2023: Childhood Obesity
#32
JOURNAL ARTICLE
Toru Matsudaira, Hironari Sano, Yumi Miyashita, Naoko Tajima, Takako Shirasawa, Hirotaka Ochiai, Akatsuki Kokaze, Rimei Nishimura
OBJECTIVES: Asians are particularly susceptible to obesity-associated disorders and rapid progression of obesity from childhood to adulthood. Data on the association between adipocytokine parameters, particularly adipocytokine ratios, and cardiovascular risk factors in childhood remain limited. Herein, we assessed the association of resistin, adiponectin, and leptin levels and leptin/adiponectin and resistin/adiponectin ratios with selected cardiovascular risk factors and the influence of unhealthy weight on such associations in children aged 9-10 years...
June 12, 2023: Journal of Pediatric Endocrinology & Metabolism: JPEM
#33
JOURNAL ARTICLE
Claudia Vales-Villamarín, Olaya de Dios, Iris Pérez-Nadador, Teresa Gavela-Pérez, Leandro Soriano-Guillén, Carmen Garcés
Obesity is associated with the presence of low-grade inflammation even during childhood. The dysregulation in the secretion of adipokines, such as leptin, which occurs in obesity states, could be associated with an increase in inflammatory factors already at an early age. In this cross-sectional study, we aimed to investigate the role of leptin levels in the association between body mass index (BMI) and high-sensitivity C-reactive protein (hs-CRP) in healthy schoolchildren. Leptin and hs-CRP levels were analyzed in two pediatric cohorts comprising 684 prepubertal children and 763 adolescents...
May 19, 2023: Nutrients
#34
JOURNAL ARTICLE
Naroa Andueza, Nerea Martin-Calvo, Santiago Navas-Carretero, Marta Cuervo
The study aimed to evaluate the efficacy of a new nutritional intervention, focused on improving the quality of the diet in children aged 6 to 12 years. A 2-month parallel, controlled randomized trial was conducted in the Spanish child population. The children were randomized to ALINFA nutritional intervention, which consisted of a normocaloric diet that incorporates products, ready-to-eat meals and healthy recipes specifically designed for the study, or a control group, which received the usual advice on healthy eating...
May 18, 2023: Nutrients
#35
JOURNAL ARTICLE
Camilo A Espinosa, Waqasuddin Khan, Rasheda Khanam, Sayan Das, Javairia Khalid, Jesmin Pervin, Margaret P Kasaro, Kévin Contrepois, Alan L Chang, Thanaphong Phongpreecha, Basil Michael, Mathew Ellenberger, Usma Mehmood, Aneeta Hotwani, Ambreen Nizar, Furqan Kabir, Ronald J Wong, Martin Becker, Eloise Berson, Anthony Culos, Davide De Francesco, Samson Mataraso, Neal Ravindra, Melan Thuraiappah, Maria Xenochristou, Ina A Stelzer, Ivana Marić, Arup Dutta, Rubhana Raqib, Salahuddin Ahmed, Sayedur Rahman, A S M Tarik Hasan, Said M Ali, Mohamed H Juma, Monjur Rahman, Shaki Aktar, Saikat Deb, Joan T Price, Paul H Wise, Virginia D Winn, Maurice L Druzin, Ronald S Gibbs, Gary L Darmstadt, Jeffrey C Murray, Jeffrey S A Stringer, Brice Gaudilliere, Michael P Snyder, Martin S Angst, Anisur Rahman, Abdullah H Baqui, Fyezah Jehan, Muhammad Imran Nisar, Bellington Vwalika, Sunil Sazawal, Gary M Shaw, David K Stevenson, Nima Aghaeepour
Preterm birth (PTB) is the leading cause of death in children under five, yet comprehensive studies are hindered by its multiple complex etiologies. Epidemiological associations between PTB and maternal characteristics have been previously described. This work used multiomic profiling and multivariate modeling to investigate the biological signatures of these characteristics. Maternal covariates were collected during pregnancy from 13,841 pregnant women across five sites. Plasma samples from 231 participants were analyzed to generate proteomic, metabolomic, and lipidomic datasets...
May 24, 2023: Science Advances
#36
JOURNAL ARTICLE
Vasiliki Karava, Antonia Kondou, John Dotis, Athanasios Christoforidis, Anna Taparkou, Evangelia Farmaki, Konstantinos Kollios, Vassilios Liakopoulos, Nikoleta Printza
OBJECTIVE: This cross-sectional study explores the association of adipokines and interleukin-6 (IL-6) with muscle and protein energy wasting (PEW) in children with chronic kidney disease (CKD). METHODS: We measured serum adiponectin, leptin, resistin and IL-6 in 53 patients with CKD stage 3-5. Lean tissue (LTI) and fat tissue index (FTI) were estimated by bioimpedance analysis spectroscopy. PEW was defined as muscle wasting [LTI adjusted to height age (LTI HA) z-score <-1...
May 11, 2023: Journal of Renal Nutrition
#37
JOURNAL ARTICLE
Inas H Mazen, Mona A El-Gammal, Aya A Elaidy, Ghada M Anwar, Engy A Ashaat, Sherif F Abdel-Ghafar, Mohamed S Abdel-Hamid
Early childhood obesity is a real public health problem worldwide. Identifying the etiologies, especially treatable and preventable causes, can direct health professionals toward proper management. Measurement of serum leptin levels is helpful in the diagnosis of congenital leptin and leptin receptor deficiencies which are considered important rare causes of early childhood obesity. The main aim of this study was to investigate the frequency of LEP, LEPR, and MC4R gene variants among a cohort of Egyptian patients with severe early onset obesity...
May 4, 2023: Molecular Genetics and Genomics: MGG
#38
JOURNAL ARTICLE
Nikhil Shah, Anuradha Khadilkar, Chirantap Oza, Shital Bhor, Dipali Ladkat, Ketan Gondhalekar, Chidvilas More, Vaman Khadilkar
OBJECTIVES: Adiponectin/leptin ratio (ALR) is a promising novel marker of cardio-metabolic risk in patients with metabolic syndrome. Our aim was to study the association of adiponectin-leptin ratio with markers of obesity and adiposity and also to assess its usefulness as a marker of increased cardiometabolic risk (CMR) in Indian children and youth with type 1 diabetes mellitus. METHODS: This observational study included 79 children and youth with type 1 diabetes (T1DM) (10-21 years) having disease duration>6 months...
May 3, 2023: Journal of Pediatric Endocrinology & Metabolism: JPEM
#39
JOURNAL ARTICLE
Joanna Gajewska, Jadwiga Ambroszkiewicz, Katarzyna Szamotulska, Grażyna Rowicka, Małgorzata Strucińska, Witold Klemarczyk, Magdalena Chełchowska
Oxidative stress is implicated in the pathophysiology of Prader-Willi syndrome (PWS), but there are no data on these disorders in non-obese children with PWS. Therefore, the presented study examined total oxidant capacity (TOC), total antioxidant capacity (TAC), the oxidative stress index (OSI), and adipokine levels in 22 non-obese children with PWS during dietary intervention and growth hormone treatment compared with 25 non-obese healthy children. Serum concentrations of TOC, TAC, nesfatin-1, leptin, hepcidin, ferroportin, and ferritin were determined using immunoenzymatic methods...
April 13, 2023: Antioxidants (Basel, Switzerland)
#40
JOURNAL ARTICLE
Maria Kaza, Charalampos Tsentidis, Elpis Vlachopapadopoulou, Spyridon Karanasios, Irine- Ikbale Sakou, George Paltoglou, George Mastorakos, Kyriaki Karavanaki
PURPOSE: Individuals with Type-1-Diabetes (T1D) are at higher risk of having premature cardiovascular-disease (CVD). Physical activity and healthy lifestyle are major components in the prevention of diabetes' related comorbidities and complications. The aim of this study was to investigate the impact of physical activity, eating habits and quality of life in children and adolescents with T1D on diabetic control, cardiovascular and biochemical profile, infection indices, and adipokine levels...
April 21, 2023: Endocrine
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