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Leptin, BMI, children

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https://www.readbyqxmd.com/read/28542631/concordance-of-bioactive-vs-total-immunoreactive-serum-leptin-levels-in-children-with-severe-early-onset-obesity
#1
Juraj Stanik, Jürgen Kratzsch, Kathrin Landgraf, Kathrin Scheuermann, Ulrike Spielau, Ruth Gausche, Daniela Gasperikova, Wieland Kiess, Antje Körner
CONTEXT: Leptin secreted from adipose tissue signals peripheral energy status to the brain. Monogenic leptin deficiency results in severe early onset obesity with hyperphagia. Recently, a similar phenotype of inactivating leptin mutations but with preserved immunoreactivity and hence normal circulating immunoreactive leptin has been reported. OBJECTIVE: We aimed to evaluate the proportion of bioactive leptin serum levels (compared to immunoreactive leptin) as a biomarker for the screening of leptin gene mutations causing monogenic obesity...
2017: PloS One
https://www.readbyqxmd.com/read/28511904/analysis-of-the-association-of-leptin-and-adiponectin-concentrations-with-metabolic-syndrome-in-children-results-from-the-idefics-study
#2
A Nappo, E M González-Gil, W Ahrens, K Bammann, N Michels, L A Moreno, Y Kourides, L Iacoviello, S Mårild, A Fraterman, D Molnàr, T Veidebaum, A Siani, P Russo
BACKGROUND AND AIMS: Adipokines may play a role in the pathogenesis of the metabolic syndrome (MetS) in children. We aimed to evaluate the association of leptin, adiponectin, and its ratio (L/A ratio) with the metabolic syndrome (MetS) in a subsample of the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS) cohort. METHODS AND RESULTS: Leptin, adiponectin and MetS parameters were measured in a subsample of 1253 children (3-9...
April 19, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28509827/leptin-elevation-as-a-risk-factor-for-slipped-capital-femoral-epiphysis-independent-of-obesity-status
#3
Schuyler J Halverson, Tracy Warhoover, Gregory A Mencio, Steven A Lovejoy, Jeffrey E Martus, Jonathan G Schoenecker
BACKGROUND: Slipped capital femoral epiphysis (SCFE) is strongly associated with childhood obesity, yet the prevalence of obesity is orders of magnitude greater than the prevalence of SCFE. Therefore, it is hypothesized that obesity is not, by itself, a sufficient condition for SCFE, but rather one component of a multifactorial process requiring preexisting physeal pathology. Leptin elevation is seen to varying degrees in patients with obesity, and as leptin has been shown to cause physeal pathology similar to the changes seen in SCFE, we propose that leptin may be a factor distinguishing between patients with SCFE and equally obese children without hip abnormalities...
May 17, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28422951/helicobacter-pylori-infection-and-serum-leptin-obestatin-and-ghrelin-levels-in-mexican-schoolchildren
#4
Carolina Romo-González, Eugenia Mendoza, Robertino M Mera, Rafael Coria-Jiménez, Patricia Chico-Aldama, Rita Gomez-Diaz, Ximena Duque
BACKGROUND: There is little information about the possible role of H. pylori infection on appetite-regulating peptides in children. This study evaluated the association between H. pylori infection and serum levels of ghrelin, leptin, and obestatin in schoolchildren. METHODS: One hundred seventy-eight schoolchildren, students at boarding schools in Mexico City, participated. H. pylori infection status was determined every six months for one year by a breath test using (13)C-urea; schoolchildren with consistently positive or negative results were selected to participate...
April 19, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28415953/influence-of-etanercept-on-leptin-and-ghrelin-secretion-in-children-with-juvenile-idiopathic-arthritis
#5
Izabela Maciejewska-Paszek, Elżbieta Grochowska-Niedworok, Andrzej Siwiec, Anna Gruenpeter, Lechosław Dul, Tomasz Irzyniec
Objective To assess possible changes in leptin and ghrelin secretion due to etanercept in juvenile idiopathic arthritis (JIA). Methods 50 patients with JIA and 16 age-matched controls were enrolled into this prospective, cross-sectional study. Serum leptin, total and acyl ghrelin were measured in addition to white blood cell (WBC) and lymphocyte counts. Results 25 patients received etanercept and 25 conventional therapies (including methotrexate) for JIA. There was no difference between treatment and control groups in leptin or ghrelin levels and no evidence of a relationship between leptin and ghrelin in patients with JIA...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28396702/interaction-between-prenatal-pesticide-exposure-and-a-common-polymorphism-in-the-pon1-gene-on-dna-methylation-in-genes-associated-with-cardio-metabolic-disease-risk-an-exploratory%C3%A2-study
#6
Ken Declerck, Sylvie Remy, Christine Wohlfahrt-Veje, Katharina M Main, Guy Van Camp, Greet Schoeters, Wim Vanden Berghe, Helle R Andersen
BACKGROUND: Prenatal environmental conditions may influence disease risk in later life. We previously found a gene-environment interaction between the paraoxonase 1 (PON1) Q192R genotype and prenatal pesticide exposure leading to an adverse cardio-metabolic risk profile at school age. However, the molecular mechanisms involved have not yet been resolved. It was hypothesized that epigenetics might be involved. The aim of the present study was therefore to investigate whether DNA methylation patterns in blood cells were related to prenatal pesticide exposure level, PON1 Q192R genotype, and associated metabolic effects observed in the children...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28393717/leptin-levels-in-children-with-obstructive-sleep-apnea-syndrome
#7
Ayhan Söğüt, Şerefden Açıkgöz, Lokman Uzun, Mehmet Birol Uğur, Remzi Altın, Elif Dağlı, Athanasios Kaditis, Refika Ersu
Introduction: The aim of this study is to assess the effect of obstructive sleep apnea syndrome (OSAS) severity on leptin levels in children. Patients and Methods: Children with habitual snoring underwent overnight polysomnography. Fasting venous blood samples were obtained between 8 AM and 9 AM, following the night of the sleep study. Children with an apnea-hypopnea index of ≥ 5/h were included in the moderate-to-severe OSAS group while those with an apnea-hypopnea index of < 5/h formed the mild OSAS/primary snoring group...
December 2016: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28366141/-leptin-levels-in-children-with-obstructive-sleep-apnea-syndrome
#8
Ayhan Söğüt, Şerefden Açıkgöz, Lokman Uzun, Mehmet Birol Uğur, Remzi Altın, Elif Dağlı, Athanasios Kaditis, Refika Ersu
Introduction: The aim of this study is to assess the effect of obstructive sleep apnea syndrome (OSAS) severity on leptin levels in children. Patients and Methods: Children with habitual snoring underwent overnight polysomnography. Fasting venous blood samples were obtained between 8 AM and 9 AM, following the night of the sleep study. Children with an apnea-hypopnea index of ≥ 5/h were included in the moderate-to-severe OSAS group while those with an apnea-hypopnea index of < 5/h formed the mild OSAS/primary snoring group...
December 2016: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28359065/evaluating-weight-status-and-sex-as-moderators-of-the-association-of-serum-leptin-with-bone-mineral-density-in-children-and-adolescents%C3%A2
#9
Sara A Armaiz-Flores, Nichole R Kelly, Ovidiu A Galescu, Andrew P Demidowich, Anne M Altschul, Sheila M Brady, Van S Hubbard, Courtney K Pickworth, Marian Tanofsky-Kraff, Lauren B Shomaker, James C Reynolds, Jack A Yanovski
BACKGROUND/AIMS: Animal studies suggest that leptin may adversely affect bone mineral density (BMD). Clinical studies have yielded conflicting results. We therefore investigated associations between leptin and bone parameters in children. METHODS: 830 healthy children (age = 11.4 ± 3.1 years; 75% female; BMI standard deviation score [BMIz] = 1.5 ± 1.1) had fasting serum leptin measured with ELISA and body composition by dual-energy X-ray absorptiometry. The main effects for leptin and BMIz plus leptin's interactions with sex and BMIz were examined using hierarchical linear regressions for appendicular, pelvis, and lumbar spine BMD as well as bone mineral content (BMC), and bone area (BA)...
March 30, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28329079/sleep-duration-and-cardiometabolic-risk-among-chinese-school-aged-children-do-adipokines-play-a-mediating-role
#10
Lujiao Li, Junling Fu, Xin Ting Yu, Ge Li, Lu Xu, Jinghua Yin, Hong Cheng, Dongqing Hou, Xiaoyuan Zhao, Shan Gao, Wenhui Li, Changhong Li, Struan F A Grant, Mingyao Li, Yi Xiao, Jie Mi, Ming Li
Study Objectives: To assess the associations between sleep duration and cardiometabolic risk factors in Chinese school-aged children and to explore the possible mediating role of adipokines. Methods: Sleep duration was collected in 3166 children from the Beijing Child and Adolescent Metabolic Syndrome study. Glucose homeostasis and other cardiometabolic risk factors were assessed. Serum adipokines including leptin, total and high-molecular-weight (HMW) adiponectin, resistin, fibroblast growth factor 21 (FGF21), and retinol binding protein 4 (RBP4) were determined...
May 1, 2017: Sleep
https://www.readbyqxmd.com/read/28239164/adipocyte-c1qtnf5-expression-is-bmi-dependently-related-to-early-adipose-tissue-dysfunction-and-systemic-ctrp5-serum-levels-in-obese-children
#11
J T Schwartze, K Landgraf, U Spielau, D Rockstroh, D Löffler, J Kratzsch, W Kiess, A Körner
BACKGROUND/OBJECTIVES: The recently identified adipocytokine C1QTNF5 (encodes for CTRP5) has been demonstrated to inhibit pro-metabolic insulin signaling in adipocytes. We hypothesized that adipocyte C1QTNF5 expression in subcutaneous (sc) adipose tissue (AT) would correlate with the degree of obesity, systemic CTRP5 serum levels, and early AT and metabolic dysfunction in children. SUBJECTS/METHODS: Sc AT samples were obtained from 33 healthy Caucasian lean children aged 10...
February 27, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28157487/comparison-of-body-composition-and-adipokine-levels-between-thin-and-normal-weight-prepubertal-children
#12
Jadwiga Ambroszkiewicz, Joanna Gajewska, Katarzyna Szamotulska, Grażyna Rowicka, Witold Klemarczyk, Magdalena Chełchowska
OBJECTIVE: Thinness can have substantial consequences for child development and health. Adipokines, including leptin and adiponectin, play a significant role in the regulation of important metabolic functions. The aim of this study was to investigate associations between body composition and serum leptin and adiponectin levels in thin and normal-weight children. METHODS: The authors examined 100 healthy prepubertal children, who were divided into two subgroups: thin (n=50) and normal-weight children (n=50)...
February 1, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28139438/fgf21-deficiency-is-associated-with-childhood-obesity-insulin-resistance-and-hypoadiponectinaemia-the-bcams-study
#13
G Li, J Yin, J Fu, L Li, S F A Grant, C Li, M Li, J Mi, M Li, S Gao
OBJECTIVE: Fibroblast growth factor 21 (FGF21) exerts beneficial effects on metabolic homoeostasis and has been reported to be regulated by adiponectin, leptin and resistin. However, while an association between increased circulating FGF21 and metabolic disorders has been reported in adults, paediatric-specific data are lacking. DESIGN AND METHODS: This study investigated the relationship between FGF21 levels and obesity, insulin resistance (IR), the metabolic syndrome (MetS) and adipokines (adiponectin, leptin and resistin) in a cohort of 3231 Chinese youngsters aged 6-18...
January 27, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28128972/leptin-and-leptin-to-adiponectin-ratio-predict-adiposity-gain-in-nonobese-children-over-a-six-year-period
#14
Meixian Zhang, Hong Cheng, Xiaoyuan Zhao, Dongqing Hou, Yinkun Yan, Katherine Cianflone, Ming Li, Jie Mi
BACKGROUND: Previous longitudinal studies have shown inconsistent results regarding the influence of adipokines on changes in weight and body fat. We aimed to determine the predictive value of serum leptin, adiponectin, and their ratio on subsequent changes in obesity measures in children. METHODS: Two hundred forty-six obese and 532 nonobese children aged 6-11 years were remeasured for BMI and waist circumference after 6.4 ± 0.2 years. Z-score of BMI was used to standardize for age and sex...
June 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28028397/vitamin-d-status-insulin-resistance-leptin-to-adiponectin-ratio-in-adolescents-results-of-a-1-year-lifestyle-intervention
#15
Christine Rambhojan, Laurent Larifla, Josiane Clepier, Elodie Bouaziz-Amar, Fritz-Line Velayoudom-Cephise, Anne Blanchet-Deverly, Christophe Armand, Jean Plumasseau, Jean-Marc Lacorte, Lydia Foucan
AIM: We aimed to study the relationships between circulating 25-hydroxyvitamin D [25(OH)D], insulin resistance and leptin-to-adiponectin (L/A) ratio in Guadeloupean children and adolescents and to analyse the changes in 25(OH)D levels after a 1-year lifestyle intervention program. METHODS: 25(OH)D concentrations were measured via a chemiluminescence assay. Cardiometabolic risk factors, homoeostasis model assessment of insulin resistance (HOMA-IR), and adipokines were measured...
December 15, 2016: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27990162/the-changes-of-serum-leptin-and-kisspeptin-levels-in-chinese-children-and-adolescents-in-different-pubertal-stages
#16
Hui Juan Zhu, Su Juan Li, Hui Pan, Naishi Li, Dian Xi Zhang, Lin Jie Wang, Hong Bo Yang, Qinyong Wu, Feng Ying Gong
The aim of the study is to investigate the changes of serum leptin and kisspeptin levels in children and adolescents with different pubertal stages and nutritional states. A total of 647 Chinese children and adolescents were recruited, and serum estradiol, testosterone, pituitary gonadotropins, leptin, and kisspeptin levels were measured. The results showed that serum leptin levels of boys in T2 stage were the highest among the five stages, while they showed a gradual increase from T1 to T5 stage in girls and reached the highest in T5 stage (P < 0...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27974716/early-bmi-gain-and-later-height-growth-predicts-higher-dheas-concentrations-in-7-year-old-chilean-children
#17
Verónica Mericq, Ana Pereira, Ricardo Uauy, Camila Corvalán
BACKGROUND: Accelerated weight and height gain in infancy have been associated with premature adrenarche. However, the exact tempo of these events remains undefined. Thus, our goal was to assess the relationship between early BMI and height growth in different periods before 7 years of age and plasma DHEAS levels at 7 years of age. METHODS: This is a longitudinal follow-up of participants of the Growth and Obesity Chilean Cohort Study (GOCS) that represents Chilean children from low- to middle-income families...
2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27806063/biomarker-profiles-in-women-with-pcos-and-pcos-offspring-a-pilot-study
#18
Nadine M P Daan, Maria P H Koster, Marlieke A de Wilde, Gerdien W Dalmeijer, Annemieke M V Evelein, Bart C J M Fauser, Wilco de Jager
OBJECTIVE: To study metabolic/inflammatory biomarker risk profiles in women with PCOS and PCOS offspring. DESIGN: Cross-sectional comparison of serum biomarkers. SETTING: University Medical Center Utrecht. PATIENTS: Hyperandrogenic PCOS women (HA-PCOS, n = 34), normoandrogenic PCOS women (NA-PCOS, n = 34), non-PCOS reference population (n = 32), PCOS offspring (n = 14, age 6-8 years), and a paedriatic reference population (n = 30)...
2016: PloS One
https://www.readbyqxmd.com/read/27753812/ssa-04-3-leptin-adiponectin-in-cardiometabolic-disease
#19
Patricio Lopez-Jaramillo
Cardiovascular diseases (CVD) are major causes of death and illness worldwide. In recent decades an increased prevalence of CVD mortality has been reported in low-medium income countries, which has been associated with changes in life styles, deficiencies in health systems and the persistence of social inequities.The metabolic syndrome comprises a cluster of cardiometabolic risk factors, with insulin resistance and increased adiposity as its central features. Identifying individuals with metabolic syndrome is important due to its association with an increased risk of coronary heart disease and type 2 diabetes mellitus (DM2)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27651112/inflammation-mediates-the-association-between-visceral-adiposity-and-obstructive-sleep-apnea-in-adolescents
#20
Jordan Gaines, Alexandros N Vgontzas, Julio Fernandez-Mendoza, Susan L Calhoun, Fan He, Duanping Liao, Marjorie D Sawyer, Edward O Bixler
Only a handful of studies, primarily in clinical samples, have reported an association between obesity, inflammation, and obstructive sleep apnea (OSA) in children and adolescents. No studies, however, have examined the pathogenetic link between visceral adiposity, systemic inflammation, and incident OSA in a large general population sample using objective measures of sleep and body fat. Adolescents (n = 392; mean age 17.0 ± 2.2 yr, 54.0% male) from the Penn State Child Cohort (PSCC) underwent 9-h overnight polysomnography; a DXA scan to assess body fat distribution; and a single fasting blood draw for the assessment of plasma interleukin-6 (IL-6), IL-6 soluble receptor (IL-6 sR), tumor necrosis factor alpha (TNFα), tumor necrosis factor receptor 1A (TNFR1), C-reactive protein (CRP), leptin, and adiponectin levels via ELISA...
November 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
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