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Leptin, BMI, children

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https://www.readbyqxmd.com/read/29759068/childhood-retinol-binding-protein-4-rbp4-levels-predicting-the-10-year-risk-of-insulin-resistance-and-metabolic-syndrome-the-bcams-study
#1
Ge Li, Issy C Esangbedo, Lu Xu, Junling Fu, Lujiao Li, Dan Feng, Lanwen Han, Xinhua Xiao, Mingyao Li, Jie Mi, Ming Li, Shan Gao, Steven M Willi
BACKGROUND: Elevated retinol-binding protein 4 (RBP4) levels may contribute to the development of metabolic abnormalities, but prospective studies evaluating the association between childhood RBP4 levels and metabolic syndrome (MS) in adulthood are lacking. We investigated whether RBP4 levels during childhood predict cardiometabolic risk at 10-year follow-up. METHODS: The relationships between RBP4 levels, the established adipokines (leptin and adiponectin) and the components of MS were examined in 3445 school-aged children recruited in 2004 for the Beijing Child and Adolescent Metabolic Syndrome study...
May 14, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29733056/asociaci%C3%A3-n-de-leptina-con-factores-cardiometab%C3%A3-licos-en-escolares-y-adolescentes-con-hiperplasia-suprarrenal-cong%C3%A3-nita
#2
Jessie Nallely Zurita-Cruz, Miguel Ángel Villasís-Keever, Leticia Damasio-Santana, Leticia Manuel-Apolinar, Rosalba Ferrusca-Ceja, Elisa Nishimura-Meguro, Aleida de J Rivera-Hernández, Eulalia Garrido-Magaña
Introducción: En la hiperplasia suprarrenal congénita (HSC), la obesidad, la hiperinsulinemia y los niveles de leptina se encuentran incrementados. Objetivo: Identificar la frecuencia de los factores de riesgo cardiometabólico (FRC) en niños y adolescentes con HSC y explorar la relación con los niveles de leptina. Método: Estudio transversal de 40 pacientes a quienes se realizó somatometría y evaluación de glucosa, insulina, triglicéridos, 17-hidroxiprogesterona, leptina, colesterol HDL y LDL en ayuno...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29731827/leptin-hs-crp-il-18-and-urinary-protein-before-and-after-treatment-of-children-with-nephrotic-syndrome
#3
Jiayun Zhou, Feng Shi, Wenlong Xun
We aimed to analyze the changes in plasma leptin, serum inflammatory factors and urinary protein in children with nephrotic syndrome before and after treatment and their clinical significance. A total of 28 children treated and diagnosed with nephrotic syndrome between November 2015 and October 2016 were selected as treatment group, while 25 healthy children were selected as control group. There were no statistically significant differences in age, sex, body mass index (BMI), serum albumin and other general data between treatment group and control group (P>0...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29714458/increased-concentrations-of-serum-nesfatin-1-levels-in-childhood-with-idiopathic-chronic-malnutrition
#4
Sezer Acar, Gönül Çatlı, Tuncay Küme, Hale Tuhan, Özlem Gürsoy Çalan, Korcan Demir, Ece Böber, Ayhan Abacı
Background/aim: Nesfatin-1, an anorexigenic molecule, seems to play a role in appetite regulation and energy homeostasis. The goal of this study was to evaluate the relation of nesfatin-1 with anthropometric and metabolic (ghrelin, leptin) parameters in children with idiopathic chronic malnutrition. Materials and methods: The study included 37 underweight and 38 healthy children who were similar regarding age, sex, and pubertal status. Anthropometric and biochemical (nesfatin-1, ghrelin, and leptin levels) variables were assessed...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29682291/metformin-in-gestational-diabetes-the-offspring-follow-up-mig-tofu-body-composition-and-metabolic-outcomes-at-7-9-years-of-age
#5
Janet A Rowan, Elaine C Rush, Lindsay D Plank, Jun Lu, Victor Obolonkin, Suzette Coat, William M Hague
Objective: To compare body composition and metabolic outcomes at 7-9 years in offspring of women with gestational diabetes (GDM) randomized to metformin (±insulin) or insulin treatment during pregnancy. Research design and methods: Children were assessed at 7 years in Adelaide (n=109/181) and 9 years in Auckland (n=99/396) by anthropometry, bioimpedance analysis (BIA), dual-energy X-ray absorptiometry (DXA), magnetic resonance imaging (MRI) (n=92/99) and fasting bloods (n=82/99)...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29679911/the-effects-of-valproate-and-topiramate-use-on-serum-insulin-leptin-neuropeptide-y-and-ghrelin-levels-in-epileptic-children
#6
Nafiye Polat Çiçek, Tülay Kamaşak, Mine Serin, Aysenur Okten, Ahmet Alver, Ali Cansu
PURPOSE: Although some drugs used in the treatment of epilepsy are known to affect body weight, the hormonal factors responsible have not been sufficiently described. The purpose of this study was to compare insulin, leptin, neuropeptide Y and ghrelin levels in children with epilepsy receiving monotherapy with topiramate (TPM) and valproic acid (VPA), the drugs whose effects on body weight have been most discussed, with those of a control group. METHOD: 48 patients (25 VPA, 23 TPM) aged between 6 and 15...
April 11, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29679223/association-between-lepr-fto-mc4r-and-pparg-2-polymorphisms-with-obesity-traits-and-metabolic-phenotypes-in-school-aged-children
#7
Sílvia M Almeida, José M Furtado, Paulo Mascarenhas, Maria E Ferraz, José C Ferreira, Mariana P Monteiro, Manuel Vilanova, Fernando P Ferraz
PURPOSE: Evaluate the relationship of leptin receptor (LEPR) rs1137101, fat mass obesity-associated (FTO) receptors 9939609, melanocortin-4 receptors (MC4R) rs2229616 and rs17782313, and proliferator-activated receptor-gamma (PPARG) rs1801282 with clinical and metabolic phenotypes in prepubertal children. RESEARCH QUESTION: What is the effect of polymorphisms on clinical and metabolic phenotypes in prepubertal children? METHODS: A cross-sectional descriptive study was performed to evaluate anthropometric features, percentage body fat (%BF), biochemical parameters, and genotype in 773 prepubertal children...
April 20, 2018: Endocrine
https://www.readbyqxmd.com/read/29575812/branched-chain-amino-acids-androgen-hormones-and-metabolic-risk-across-early-adolescence-a-prospective-study-in-project-viva
#8
Wei Perng, Sheryl L Rifas-Shiman, Marie-France Hivert, Jorge E Chavarro, Emily Oken
OBJECTIVE: This study aimed to examine the associations of two obesity-related metabolite patterns with changes in metabolic biomarkers during early adolescence. METHODS: Multivariable linear regression was used to examine associations of branched chain amino acid (BCAA) and androgen hormone patterns with changes in glycemia (fasting glucose, insulin, homeostatic model assessment of insulin resistance), adipokines (leptin, adiponectin), inflammation (C-reactive protein, interleukin-6), lipid profile, and blood pressure during ∼5 years of follow-up among 213 children aged 6 to 10 years at baseline...
March 25, 2018: Obesity
https://www.readbyqxmd.com/read/29568105/early-childhood-bmi-trajectories-in-monogenic-obesity-due-to-leptin-leptin-receptor-and-melanocortin-4-receptor-deficiency
#9
Katja Kohlsdorf, Adriana Nunziata, Jan-Bernd Funcke, Stephanie Brandt, Julia von Schnurbein, Heike Vollbach, Belinda Lennerz, Maria Fritsch, Susanne Greber-Platzer, Elke Fröhlich-Reiterer, Manuel Luedeke, Guntram Borck, Klaus-Michael Debatin, Pamela Fischer-Posovszky, Martin Wabitsch
OBJECTIVE: To evaluate whether early childhood body mass index (BMI) is an appropriate indicator for monogenic obesity. METHODS: A cohort of n = 21 children living in Germany or Austria with monogenic obesity due to congenital leptin deficiency (group LEP, n = 6), leptin receptor deficiency (group LEPR, n = 6) and primarily heterozygous MC4 receptor deficiency (group MC4R, n = 9) was analyzed. A control group (CTRL) was defined that consisted of n = 22 obese adolescents with no mutation in the above mentioned genes...
February 27, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29476734/bioactive-leptin-is-stronger-related-to-parameters-of-fat-mass-and-distribution-than-conventionally-measured-leptin-findings-from-a-longitudinal-study-in-obese-children-participating-in-a-lifestyle-intervention
#10
Petra Niklowitz, Juliane Rothermel, Nina Lass, Andre Barth, Thomas Reinehr
OBJECTIVE: This study analyzed the relationships between bioactive leptin, conventionally measured leptin, and parameters of fat mass and distribution in obese children before and after weight reduction. METHODS: We determined bioactive leptin (bioLep), conventional measured leptin (conLep), weight, height, body fat based on skinfold measurements and bioimpedance analyses, waist circumference (wc), and pubertal stage in 88 obese children participating in a lifestyle intervention at baseline and one year later...
May 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29445241/is-early-life-exposure-to-polyomaviruses-and-herpesviruses-associated-with-obesity-indices-and-metabolic-traits-in-childhood
#11
Marianna Karachaliou, Silvia de Sanjose, Tim Waterboer, Theano Roumeliotaki, Maria Vassilaki, Katerina Sarri, Vasiliki Leventakou, Marina Vafeiadi, Georgia Chalkiadaki, Eftichia Stiakaki, Angelika Michel, Michael Pawlita, Manolis Kogevinas, Leda Chatzi
BACKGROUND: Evidence for an infectious origin of obesity is emerging. We explored whether common viruses were associated with obesity and metabolic traits. METHODS: We used cross-sectional (n = 674) and prospective (n = 440) data from children participating at the 4 and 6 years of age follow-up in the Rhea birth cohort. Presence of IgG antibodies to ten polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, HPyV6, HPyV7, TSPyV, MCPyV, HPyV9, and HPyV10) and four herpesviruses (EBV, CMV, HSV-1, and HSV-2) were measured at age 4...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29412799/correlation-between-serum-leptin-and-its-gene-expression-to-the-anthropometric-measures-in-overweight-and-obese-children
#12
Maha K Eldosouky, Azza M Abdu Allah, Abeer AbdElmoneim, Najat Saaeid Al-Ahmadi
Obesity is a multifactor disorder with evidence supporting the role of the genetic factor in its etiology. The present study evaluates the relationship between leptin G2548A (rs7799039) and leptin receptors (Gln223Arg (rs1137101) genotyping and its leptin level and the risk of childhood obesity. This case-control study was conducted on 168 overweight and obese Saudi children and 126 non obese one served as control. Fasting insulin, leptin, blood glucose, lipid profile levels were measured. HOMA- IR, and BMI were assessed...
January 31, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29410008/changes-in-eating-behavior-and-plasma-leptin-in-children-with-obesity-participating-in-a-family-centered-lifestyle-intervention
#13
Tamara R Cohen, Tom J Hazell, Catherine A Vanstone, Celia Rodd, Hope A Weiler
The goal of childhood obesity lifestyle interventions are to positively change body composition, however it is unknown if interventions also modulate factors that are related to energy intake. This study aimed to examine changes in eating behaviors and plasma leptin concentrations in overweight and obese children participating in a 1-year family-centered lifestyle intervention. Interventions were based on Canadian diet and physical activity (PA) guidelines. Children were randomized to 1 of 3 groups: Control (Ctrl; no intervention), Standard treatment (StnTx: 2 servings milk and alternatives/day (d), 3x/wk weight-bearing PA), or Modified treatment (ModTx: 4 servings milk and alternatives/day; daily weight-bearing PA)...
June 1, 2018: Appetite
https://www.readbyqxmd.com/read/29379539/enteric-parasites-can-disturb-leptin-and-adiponectin-levels-in-children
#14
Raida S Yahya, Soha I Awad, Nadeem Kizilbash, Hatim A El-Baz, Gehan Atia
Introduction: Infection by intestinal parasites in childhood may be the main cause of many health-related problems in developed countries such as anemia, anorexia, loss of appetite, retarded growth and development. The aim of the present study was to assess the effect of different intestinal parasites on white adipose tissue hormones. Material and methods: Eighty-one children infected by different parasites and 35 apparently healthy children were enrolled in this study...
January 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29320782/thyroid-hormone-status-in-overweight-children-with-attention-deficit-hyperactivity-disorder
#15
Christian Langrock, Johannes Hebebrand, Katharina Radowksi, Eckard Hamelmann, Thomas Lücke, Martin Holtmann, Tanja Legenbauer, Börge Schmidt, Mirjam Frank, Karl-Heinz Jöckel, Thomas Reinehr
BACKGROUND: There is an ongoing discussion whether thyroid hormones are involved in the development and course of attention deficit/hyperactivity disorder (ADHD). Since obesity is associated with both higher thyroid-stimulating hormone (TSH) and free triiodothyronine (fT3) concentrations and increased rates of ADHD, we hypothesized that overweight children with ADHD show higher TSH and fT3 concentrations compared to overweight children without ADHD. METHODS: TSH, fT3, fT4, and leptin levels were analyzed in 230 children (60...
January 10, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29314270/association-of-leptin-with-disease-severity-and-inflammation-indicators-in-chinese-obese-children-with-allergic-rhinitis
#16
Wenlong Liu, Qingxiang Zeng, Lifeng Zhou, Renzhong Luo, Haipeng Dong
BACKGROUND: The prevalence of both obesity and allergic diseases in children has increased over the last several decades. However, the direct relationship between diverse allergic diseases and obesity has varied in different studies. Therefore, we aimed to examine the effect of obesity on the incidence and severity of allergic rhinitis (AR) and the possible key inflammation mediators during AR. METHODS: A total of 3126 healthy students (without chronic diseases) were recruited from 14 randomly selected secondary schools in Guangzhou, China...
March 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29246331/impact-of-severe-obesity-on-cardiovascular-risk-factors-in-youth
#17
Gali Zabarsky, Cherise Beek, Emilia Hagman, Bridget Pierpont, Sonia Caprio, Ram Weiss
OBJECTIVE: To compare cardiovascular risk factor clustering (CVRFC) in severely obese youth with those with lower degrees of obesity. STUDY DESIGN: We divided a childhood obesity clinic derived cohort into the degrees of obesity (class I, II, and III) and added a "class IV" category corresponding to >160% of the 95th centile of body mass index (BMI) for age and sex. In a cross-sectional analysis, we investigated the presence of CVRFC in 2244 participants; in 621 who were followed longitudinally, we investigated the determinants of endpoint CVRFC...
January 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29205916/leptin-in-maternal-plasma-and-cord-blood-as-a-predictor-of-offspring-adiposity-at-5-years-a-follow-up-study
#18
Dorothy Marie Meyer, Christina Brei, Lynne Stecher, Daniela Much, Stefanie Brunner, Hans Hauner
OBJECTIVE: Perinatal leptin exposure may modulate the risk of adiposity in early childhood. In previous analyses, negative associations between maternal (32 weeks' gestation) and cord blood leptin and offspring body composition at 2 years were observed. METHODS: Associations between maternal/cord blood leptin were assessed with indirect (i.e., body weight, BMI percentiles, sum of 4 skinfold thicknesses), and direct (i.e., ultrasonography, magnetic resonance imaging in a subgroup) growth and adipose tissue (AT) measurements in 120 children aged 3 to 5 years...
February 2018: Obesity
https://www.readbyqxmd.com/read/29192796/the-effect-of-weight-loss-on-body-composition-serum-bone-markers-and-adipokines-in-prepubertal-obese-children-after-1-year-intervention
#19
Joanna Gajewska, Jadwiga Ambroszkiewicz, Witold Klemarczyk, Magdalena Chełchowska, Halina Weker, Katarzyna Szamotulska
Purpose/Aim: The influence of weight loss on bone turnover and bone quality in childhood remains controversial, but it may implicate interactions between adiposity and bone metabolism. Therefore, we studied the relationships between bone markers and adipokines during weight loss in obese children. MATERIALS AND METHODS: We determined serum leptin, soluble leptin receptor, adiponectin, bone alkaline phosphatase (BALP), C-terminal telopeptide of type I collagen (CTX-I), osteocalcin (OC), carboxylated-OC (Gla-OC), undercarboxylated-OC (Glu-OC), sclerostin, body composition, and bone mineral density (BMD) in 40 obese prepubertal children before and after therapy...
December 1, 2017: Endocrine Research
https://www.readbyqxmd.com/read/29093301/adipokines-are-associated-with-hypertension-in-metabolically-healthy-obese-mho-children-and-adolescents-a-prospective-population-based-cohort-study
#20
Wenqing Ding, Hong Cheng, Fangfang Chen, Yinkun Yan, Meixian Zhang, Xiaoyuan Zhao, Dongqing Hou, Jie Mi
BACKGROUND: The potential mechanism underlying the relationship between the risk of cardiovascular diseases and metabolically healthy obese (MHO) individuals remains unclear. The aim of the study was to prospectively investigate the potential role of the adipokines in the association between the MHO phenotype and hypertension in children and adolescents. METHODS: A total of 1184 participants at baseline were recruited from a cohort of the Beijing Child and Adolescent Metabolic Syndrome (BCAMS) study...
January 5, 2018: Journal of Epidemiology
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