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Leptin, BMI, children

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https://www.readbyqxmd.com/read/28904569/serum-insulin-and-leptin-levels-in-children-with-epilepsy-on-valproate-associated-obesity
#1
Talha Rehman, Deepak Sachan, Anubhuti Chitkara
BACKGROUND: Weight gain is a common adverse effect of sodium valproic acid (VPA) in children with epilepsy. Several mechanisms of VPA-induced obesity have been suggested such as increased appetite, facultative thermogenesis, and elevated insulin and leptin levels. In this study, we aimed to investigate the role of Insulin and Leptin in the pathogenesis of weight gain caused by VPA. MATERIALS AND METHODS: Body mass index (BMI) was calculated, and serum insulin and leptin levels were measured in 45 consecutive patients and 45 controls...
April 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28900314/evaluation-of-metabolic-syndrome-and-related-factors-in-children-affected-by-acute-lymphoblastic-leukemia
#2
Soheila Zareifar, Sezaneh Haghpanah, Eslam Shorafa, Nader Shakibazad, Zohreh Karamizadeh
INTRODUCTION: Obesity is among the medical problems in survivors of childhood acute lymphoblastic leukemia (ALL). These patients are at risk of metabolic syndrome (MS). The present study aimed to follow the patients with ALL regarding the incidence of MS. PATIENTS AND METHODS: This study was conducted on all patients who referred to the oncology clinic from July 2012 to July 2013. The exclusion criteria of the study were ALL relapse, secondary malignancy, hypothyroidism, Down syndrome, and below 2 years of age...
April 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28898241/alterations-in-the-programming-of-energy-metabolism-in-adolescents-with-background-exposure-to-dioxins-dl-pcbs-and-pbdes
#3
Marike M Leijs, Janna G Koppe, Thomas Vulsma, Kees Olie, Wim M C van Aalderen, Pim de Voogt, Juliette Legler, Gavin W Ten Tusscher
OBJECTIVES: Dioxins and PCBs are highly toxic and persistent environmental pollutants that are measurable in humans worldwide. These persistent organic pollutants are associated with a higher incidence of diabetes mellitus. We hypothesise that perinatal (background) exposure to industrial pollutants like dioxins also influences body mass development and energy metabolism in later life. STUDY DESIGN: In The Netherlands, the perinatal exposure (prenatal exposure and postnatal lactational intake) to dioxins has been studied prospectively since 1987...
2017: PloS One
https://www.readbyqxmd.com/read/28893745/a-new-risk-locus-in-chchd5-for-hypertension-and-obesity-in-a-chinese-child-population-a-cohort-study
#4
Lijun Wu, Liwang Gao, Xiaoyuan Zhao, Meixian Zhang, Jianxin Wu, Jie Mi
OBJECTIVE: Coiled-coil-helix-coiled-coil-helix domain containing 5 (CHCHD5), a mitochondrial protein, is involved in the oxidative folding process in the mitochondrial intermembrane space. A previous study identified a hypertension-related single nucleotide polymorphism (SNP), rs3748024, in CHCHD5 in adults, but there are no reports regarding the association between CHCHD5 and obesity, which is a known risk factor for hypertension. The aim of the present study is to investigate the associations of the SNP rs3748024 with hypertension and obesity...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28817652/metabolomics-reveals-an-entanglement-of-fasting-leptin-concentrations-with-fatty-acid-oxidation-and-gluconeogenesis-in-healthy-children
#5
Franca Fabiana Kirchberg, Stephanie Brandt, Anja Moß, Wolfgang Peissner, Wolfgang Koenig, Dietrich Rothenbacher, Hermann Brenner, Berthold Koletzko, Christian Hellmuth, Martin Wabitsch
BACKGROUND: Leptin and adiponectin communicate with organ systems in order to regulate energetic and metabolic homeostasis. Their different points of action have been well characterized; however, no study has investigated their interrelationship with the metabolism at the molecular level in vivo. OBJECTIVE: To examine the associations of leptin and adiponectin with the metabolic profile reflecting the intercellular and interorgan communication as well as activated metabolic pathways...
2017: PloS One
https://www.readbyqxmd.com/read/28811937/association-between-salivary-leptin-levels-and-taste-perception-in-children
#6
Lénia Rodrigues, Rosa Espanca, Ana Rodrigues Costa, Célia Miguel Antunes, Clarinda Pomar, Fernando Capela-Silva, Cristina Conceição Pinheiro, Francisco Amado, Elsa Lamy
The satiety inducing hormone leptin acts not only at central nervous system but also at peripheral level. Leptin receptors are found in several sense related organs, including the mouth. A role of leptin in sweet taste response has been suggested but, until now, studies have been based on in vitro experiments, or in assessing the levels of the hormone in circulation. The present study investigated whether the levels of leptin in saliva are related to taste perception in children and whether Body Mass Index (BMI) affects such relationship...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/28774733/current-child-but-not-maternal-snoring-is-bi-directionally-related-to-adiposity-and-cardiometabolic-risk-markers-a-cross-sectional-and-a-prospective-cohort-analysis
#7
Olivia M Farr, Sheryl L Rifas-Shiman, Emily Oken, Elsie M Taveras, Christos S Mantzoros
PURPOSE: Obstructive sleep apnea (OSA), typically manifested as snoring, is closely associated with obesity. However, the directionality of associations of OSA with cardiometabolic risk markers is unclear, as obesity increases risk for OSA, and OSA results in excess weight gain and its metabolic consequences. Less is known about how obesity and OSA may relate in children and adolescents and whether maternal OSA may influence the development of obesity and cardiometabolic dysfunction in offspring...
June 29, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28771179/leptin-receptor-gene-variant-rs11804091-is-associated-with-bmi-and-insulin-resistance-in-spanish-female-obese-children-a-case-control-study
#8
Josune Olza, Azahara I Rupérez, Mercedes Gil-Campos, Rosaura Leis, Ramón Cañete, Rafael Tojo, Ángel Gil, Concepción M Aguilera
Leptin is an endocrine hormone that has a critical role in body weight homoeostasis and mediates its effects via the leptin receptor (LEPR). Common polymorphisms in the genes coding leptin receptors have been associated with metabolic abnormalities. We assessed the association of 28 LEPR polymorphisms with body mass index (BMI) and their relationship with obesity-related phenotypes, inflammation and cardiovascular disease risk biomarkers. A multicentre case-control study was conducted in 522 children (286 with obesity and 236 with normal-BMI)...
August 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28759403/metformin-for-obesity-in-prepubertal-and-pubertal-children-a-randomized-controlled-trial
#9
RANDOMIZED CONTROLLED TRIAL
Belén Pastor-Villaescusa, M Dolores Cañete, Javier Caballero-Villarraso, Raúl Hoyos, Miriam Latorre, Rocío Vázquez-Cobela, Julio Plaza-Díaz, José Maldonado, Gloria Bueno, Rosaura Leis, Ángel Gil, Ramón Cañete, Concepción M Aguilera
OBJECTIVES: Metformin has shown its effectiveness in treating obesity in adults. However, little research has been conducted in children, with a lack of attention on pubertal status. The objectives were to determine whether oral metformin treatment reduces BMI z score, cardiovascular risk, and inflammation biomarkers in children who are obese depending on pubertal stage and sex. METHODS: This was a randomized, prospective, double-blind, placebo-controlled, multicenter trial, stratified according to pubertal stage and sex, conducted at 4 Spanish clinical hospitals...
July 2017: Pediatrics
https://www.readbyqxmd.com/read/28749784/concentrations-of-leptin-adiponectin-and-other-metabolic-parameters-in-non-obese-children-with-down-syndrome
#10
Nikhil Tenneti, Devi Dayal, Sheetal Sharda, Inusha Panigrahi, Mohammed Didi, Savita Verma Attri, Naresh Sachdeva, Anil Kumar Bhalla
BACKGROUND: Recent data indicates that adults with Down syndrome (DS) are at increased risk for cardiovascular disease (CVD) that significantly contributes to their morbidity and mortality. Although identification of cardiometabolic risk factors during childhood is desirable to design preventive interventions, the data on such risk factors in children with DS is scarce. The aim of this study was to study the cardiometabolic risk factors such as insulin resistance (IR), leptin and adiponectin concentrations, lipid abnormalities and leptin resistance in non-obese children with DS...
August 28, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28743192/searching-for-evidence-of-an-anti-inflammatory-diet-in-children-a-systematic-review-of-randomized-controlled-trials-for-pediatric-obesity-interventions-with-a-focus-on-leptin-ghrelin-and-adiponectin
#11
Kimberly A Lewis, Sharon A Brown
PROBLEM: To address the complex phenomenon of pediatric obesity, one must understand the physiological mechanisms regulating energy intake and inflammation. The peptide hormones leptin, ghrelin, and adiponectin are involved in both, but their functions are dysregulated in obesity. The purpose of this systematic review is (1) to characterize studies of nutrition interventions for weight management in children who measure these peptides as outcomes, (2) to assess risk of bias in the studies, and (3) to determine the relationships between these peptides and body mass index (BMI)...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/28728946/serum-galectin-1-levels-are-positively-correlated-with-body-fat-and-negatively-with-fasting-glucose-in-obese-children
#12
Sezer Acar, Ahu Paketçi, Tuncay Küme, Hale Tuhan, Özlem Gürsoy Çalan, Korcan Demir, Ece Böber, Ayhan Abacı
Galectin-1, a recently identified peptide, is primarily released from the adipose tissue. Although galectin-1 was shown to have an anti-inflammatory effect, its specific function is not clearly understood. We aimed to evaluate the relationship of serum galectin-1 levels with clinical and laboratory parameters in childhood obesity. A total of 45 obese children (mean age: 12.1±3.1years) and 35 normal-weight children (mean age: 11.8±2.2years) were enrolled. Clinical [body mass index (BMI), waist circumference (WC), percentage of body fat and blood pressure] and biochemical [glucose, insulin, lipids, galectin-1, high-sensitive C-reactive protein (hsCRP) and leptin levels] parameters were assessed...
July 17, 2017: Peptides
https://www.readbyqxmd.com/read/28718186/intrauterine-growth-restriction-iugr-induces-signs-of-subclinical-atherosclerosis-in-6-year-old-infants-despite-absence-of-excessive-growth
#13
Anja Tzschoppe, Rüdiger von Kries, Ellen Struwe, Wolfgang Rascher, Helmuth-Guenther Dörr, Jörg Jüngert, Manfred Rauh, Matthias Beckmann, Ralf Schild, Tamme W Goecke, Jörg Dötsch
Background Postnatal catch-up growth and rapid weight gain after intrauterine growth restriction (IUGR) seem to increase the risk for later disease. This study aimed to compare features of the metabolic syndrome early in life between IUGR and appropriate for gestational age (AGA) infants. Patients Data for 9 infants with IUGR defined by a birth weight<10(th) percentile and ultrasound-proven placental insufficiency and 11 AGA children were available. Method Postnatal growth, auxological, cardiovascular, and metabolic parameters up to a chronological age of 6 years were assessed: Fasting serum concentrations of LDL-cholesterol, insulin, leptin, IGF-I, DHEAS, skinfold thicknesses, blood pressure, and mean carotid intima-media thickness (cIMT)...
July 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28636414/non-dipping-status-and-selected-adipokines-concentration-in-children-with-primary-arterial-hypertension
#14
Agnieszka Jędzura, Piotr Adamczyk, Omar Bjanid, Elżbieta Świętochowska, Dagmara Roszkowska-Bjanid, Anna Baraniecka, Beata Banaszak, Krzysztof Plesiński, Aurelia Morawiec-Knysak, Katarzyna Ziora, Maria Szczepańska
High blood pressure (BP) in children and adolescents is associated with increased risk of persistent hypertension (HT) in adulthood and, consequently, cardiovascular disease and target organ damage. AIM: The values of selected anthropometric parameters and laboratory test results including leptin and apelin concentration were evaluated with regard to averaged values of office BP measurements and 24-hour ABPM. MATERIAL AND METHODS: The study included 55 children: 23-with primary HT and coexisting overweight or obese (HT-OB), 16-with primary HT and normal weight (HT-NW), and 16 healthy children (C)...
June 21, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28588306/metabolomics-allows-the-discrimination-of-the-pathophysiological-relevance-of-hyperinsulinism-in-obese-prepubertal-children
#15
G Á Martos-Moreno, A Mastrangelo, V Barrios, A García, J A Chowen, F J Rupérez, C Barbas, J Argente
BACKGROUND/OBJECTIVES: Insulin resistance (IR) is the cornerstone of the obesity-associated metabolic derangements observed in obese children. Targeted metabolomics was employed to explore the pathophysiological relevance of hyperinsulinemia in childhood obesity in order to identify biomarkers of IR with potential clinical application. SUBJECTS/METHODS: One hundred prepubertal obese children (50 girls/50 boys, 50% IR and 50% non-IR in each group), underwent an oral glucose tolerance test for usual carbohydrate and lipid metabolism determinations...
June 7, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28542631/concordance-of-bioactive-vs-total-immunoreactive-serum-leptin-levels-in-children-with-severe-early-onset-obesity
#16
Juraj Stanik, Jürgen Kratzsch, Kathrin Landgraf, Kathrin Scheuermann, Ulrike Spielau, Ruth Gausche, Daniela Gasperikova, Wieland Kiess, Antje Körner
CONTEXT: Leptin secreted from adipose tissue signals peripheral energy status to the brain. Monogenic leptin deficiency results in severe early onset obesity with hyperphagia. Recently, a similar phenotype of inactivating leptin mutations but with preserved immunoreactivity and hence normal circulating immunoreactive leptin has been reported. OBJECTIVE: We aimed to evaluate the proportion of bioactive leptin serum levels (compared to immunoreactive leptin) as a biomarker for the screening of leptin gene mutations causing monogenic obesity...
2017: PloS One
https://www.readbyqxmd.com/read/28511904/analysis-of-the-association-of-leptin-and-adiponectin-concentrations-with-metabolic-syndrome-in-children-results-from-the-idefics-study
#17
MULTICENTER STUDY
A Nappo, E M González-Gil, W Ahrens, K Bammann, N Michels, L A Moreno, Y Kourides, L Iacoviello, S Mårild, A Fraterman, D Molnàr, T Veidebaum, A Siani, P Russo
BACKGROUND AND AIMS: Adipokines may play a role in the pathogenesis of the metabolic syndrome (MetS) in children. We aimed to evaluate the association of leptin, adiponectin, and its ratio (L/A ratio) with the metabolic syndrome (MetS) in a subsample of the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS) cohort. METHODS AND RESULTS: Leptin, adiponectin and MetS parameters were measured in a subsample of 1253 children (3-9...
June 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28509827/leptin-elevation-as-a-risk-factor-for-slipped-capital-femoral-epiphysis-independent-of-obesity-status
#18
Schuyler J Halverson, Tracy Warhoover, Gregory A Mencio, Steven A Lovejoy, Jeffrey E Martus, Jonathan G Schoenecker
BACKGROUND: Slipped capital femoral epiphysis (SCFE) is strongly associated with childhood obesity, yet the prevalence of obesity is orders of magnitude greater than the prevalence of SCFE. Therefore, it is hypothesized that obesity is not, by itself, a sufficient condition for SCFE, but rather one component of a multifactorial process requiring preexisting physeal pathology. Leptin elevation is seen to varying degrees in patients with obesity, and as leptin has been shown to cause physeal pathology similar to the changes seen in SCFE, we propose that leptin may be a factor distinguishing between patients with SCFE and equally obese children without hip abnormalities...
May 17, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28422951/helicobacter-pylori-infection-and-serum-leptin-obestatin-and-ghrelin-levels-in-mexican-schoolchildren
#19
Carolina Romo-González, Eugenia Mendoza, Robertino M Mera, Rafael Coria-Jiménez, Patricia Chico-Aldama, Rita Gomez-Diaz, Ximena Duque
BackgroundThere is little information about the possible role of Helicobacter pylori infection on appetite-regulating peptides in children. This study evaluated the association between H. pylori infection and serum levels of ghrelin, leptin, and obestatin in schoolchildren.MethodsOne hundred seventy-eight schoolchildren, students at boarding schools in Mexico City, participated. H. pylori infection status was determined every 6 months for 1 year by a breath test using (13)C-urea; schoolchildren with consistently positive or negative results were selected to participate...
October 2017: Pediatric Research
https://www.readbyqxmd.com/read/28415953/influence-of-etanercept-on-leptin-and-ghrelin-secretion-in-children-with-juvenile-idiopathic-arthritis
#20
Izabela Maciejewska-Paszek, Elżbieta Grochowska-Niedworok, Andrzej Siwiec, Anna Gruenpeter, Lechosław Dul, Tomasz Irzyniec
Objective To assess possible changes in leptin and ghrelin secretion due to etanercept in juvenile idiopathic arthritis (JIA). Methods 50 patients with JIA and 16 age-matched controls were enrolled into this prospective, cross-sectional study. Serum leptin, total and acyl ghrelin were measured in addition to white blood cell (WBC) and lymphocyte counts. Results 25 patients received etanercept and 25 conventional therapies (including methotrexate) for JIA. There was no difference between treatment and control groups in leptin or ghrelin levels and no evidence of a relationship between leptin and ghrelin in patients with JIA...
April 2017: Journal of International Medical Research
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