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Leptin, BMI, children

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https://www.readbyqxmd.com/read/29320782/thyroid-hormone-status-in-overweight-children-with-attention-deficit-hyperactivity-disorder
#1
Christian Langrock, Johannes Hebebrand, Katharina Radowksi, Eckard Hamelmann, Thomas Lücke, Martin Holtmann, Tanja Legenbauer, Börge Schmidt, Mirjam Frank, Karl-Heinz Jöckel, Thomas Reinehr
BACKGROUND: There is an ongoing discussion whether thyroid hormones are involved in the development and course of attention deficit/hyperactivity disorder (ADHD). Since obesity is associated with both higher thyroid-stimulating hormone (TSH) and free triiodothyronine (fT3) concentrations and increased rates of ADHD, we hypothesized that overweight children with ADHD show higher TSH and fT3 concentrations compared to overweight children without ADHD. METHODS: TSH, fT3, fT4, and leptin levels were analyzed in 230 children (60...
January 10, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29314270/association-of-leptin-with-disease-severity-and-inflammation-indicators-in-chinese-obese-children-with-allergic-rhinitis
#2
Wenlong Liu, Qingxiang Zeng, Lifeng Zhou, Renzhong Luo, Haipeng Dong
BACKGROUND: The prevalence of both obesity and allergic diseases in children has increased over the last several decades. However, the direct relationship between diverse allergic diseases and obesity has varied in different studies. Therefore, we aimed to examine the effect of obesity on the incidence and severity of allergic rhinitis (AR) and the possible key inflammation mediators during AR. METHODS: A total of 3,126 healthy students (without chronic diseases) were recruited from 14 randomly selected secondary schools in Guangzhou, China...
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29246331/impact-of-severe-obesity-on-cardiovascular-risk-factors-in-youth
#3
Gali Zabarsky, Cherise Beek, Emilia Hagman, Bridget Pierpont, Sonia Caprio, Ram Weiss
OBJECTIVE: To compare cardiovascular risk factor clustering (CVRFC) in severely obese youth with those with lower degrees of obesity. STUDY DESIGN: We divided a childhood obesity clinic derived cohort into the degrees of obesity (class I, II, and III) and added a "class IV" category corresponding to >160% of the 95th centile of body mass index (BMI) for age and sex. In a cross-sectional analysis, we investigated the presence of CVRFC in 2244 participants; in 621 who were followed longitudinally, we investigated the determinants of endpoint CVRFC...
January 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29205916/leptin-in-maternal-plasma-and-cord-blood-as-a-predictor-of-offspring-adiposity-at-5-years-a-follow-up-study
#4
Dorothy Marie Meyer, Christina Brei, Lynne Stecher, Daniela Much, Stefanie Brunner, Hans Hauner
OBJECTIVE: Perinatal leptin exposure may modulate the risk of adiposity in early childhood. In previous analyses, negative associations between maternal (32 weeks' gestation) and cord blood leptin and offspring body composition at 2 years were observed. METHODS: Associations between maternal/cord blood leptin were assessed with indirect (i.e., body weight, BMI percentiles, sum of 4 skinfold thicknesses), and direct (i.e., ultrasonography, magnetic resonance imaging in a subgroup) growth and adipose tissue (AT) measurements in 120 children aged 3 to 5 years...
December 3, 2017: Obesity
https://www.readbyqxmd.com/read/29192796/the-effect-of-weight-loss-on-body-composition-serum-bone-markers-and-adipokines-in-prepubertal-obese-children-after-1-year-intervention
#5
Joanna Gajewska, Jadwiga Ambroszkiewicz, Witold Klemarczyk, Magdalena Chełchowska, Halina Weker, Katarzyna Szamotulska
Purpose/Aim: The influence of weight loss on bone turnover and bone quality in childhood remains controversial, but it may implicate interactions between adiposity and bone metabolism. Therefore, we studied the relationships between bone markers and adipokines during weight loss in obese children. MATERIALS AND METHODS: We determined serum leptin, soluble leptin receptor, adiponectin, bone alkaline phosphatase (BALP), C-terminal telopeptide of type I collagen (CTX-I), osteocalcin (OC), carboxylated-OC (Gla-OC), undercarboxylated-OC (Glu-OC), sclerostin, body composition, and bone mineral density (BMD) in 40 obese prepubertal children before and after therapy...
December 1, 2017: Endocrine Research
https://www.readbyqxmd.com/read/29093301/adipokines-are-associated-with-hypertension-in-metabolically-healthy-obese-mho-children-and-adolescents-a-prospective-population-based-cohort-study
#6
Wenqing Ding, Hong Cheng, Fangfang Chen, Yinkun Yan, Meixian Zhang, Xiaoyuan Zhao, Dongqing Hou, Jie Mi
BACKGROUND: The potential mechanism underlying the relationship between the risk of cardiovascular diseases and metabolically healthy obese (MHO) individuals remains unclear. The aim of the study was to prospectively investigate the potential role of the adipokines in the association between the MHO phenotype and hypertension in children and adolescents. METHODS: A total of 1184 participants at baseline were recruited from a cohort of the Beijing Child and Adolescent Metabolic Syndrome (BCAMS) study...
October 25, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/29073286/differential-adipokine-receptor-expression-on-circulating-leukocyte-subsets-in-lean-and-obese-children
#7
Genoveva Keustermans, Laila B van der Heijden, Berlinda Boer, Rianne Scholman, Roos Nuboer, Gerard Pasterkamp, Berent Prakken, Wilco de Jager, Eric Kalkhoven, Arieke J Janse, Henk S Schipper
BACKGROUND: Childhood obesity prevalence has increased worldwide and is an important risk factor for type 2 diabetes (T2D) and cardiovascular disease (CVD). The production of inflammatory adipokines by obese adipose tissue contributes to the development of T2D and CVD. While levels of circulating adipokines such as adiponectin and leptin have been established in obese children and adults, the expression of adiponectin and leptin receptors on circulating immune cells can modulate adipokine signalling, but has not been studied so far...
2017: PloS One
https://www.readbyqxmd.com/read/29027597/lipoprotein-associated-phospholipase-a2-activity-in-obese-adolescents-with-and-without-type-2-diabetes
#8
Julia Seyfarth, Thomas Reinehr, Annika Hoyer, Christina Reinauer, Christina Bächle, Beate Karges, Ertan Mayatepek, Michael Roden, Sabine E Hofer, Susanna Wiegand, Joachim Woelfle, Wieland Kiess, Joachim Rosenbauer, Reinhard W Holl, Thomas Meissner
Lipoprotein-associated phospholipase A2 (Lp-PLA2) was identified as a strong predictor for cardiovascular events. Furthermore, it is highly associated with obesity. The role of Lp-PLA2 in diabetes mellitus is controversial and analyses, especially in adolescents with type 2 diabetes (T2D), are missing. Therefore, we compared Lp-PLA2 activity between two obese age-, sex-, and BMI-matched cohorts of adolescents with and without T2D. Relationships between Lp-PLA2 activity and age, BMI, hemoglobin A1c, lipids, and adipokines were evaluated...
October 13, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28904569/serum-insulin-and-leptin-levels-in-children-with-epilepsy-on-valproate-associated-obesity
#9
Talha Rehman, Deepak Sachan, Anubhuti Chitkara
BACKGROUND: Weight gain is a common adverse effect of sodium valproic acid (VPA) in children with epilepsy. Several mechanisms of VPA-induced obesity have been suggested such as increased appetite, facultative thermogenesis, and elevated insulin and leptin levels. In this study, we aimed to investigate the role of Insulin and Leptin in the pathogenesis of weight gain caused by VPA. MATERIALS AND METHODS: Body mass index (BMI) was calculated, and serum insulin and leptin levels were measured in 45 consecutive patients and 45 controls...
April 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28900314/evaluation-of-metabolic-syndrome-and-related-factors-in-children-affected-by-acute-lymphoblastic-leukemia
#10
Soheila Zareifar, Sezaneh Haghpanah, Eslam Shorafa, Nader Shakibazad, Zohreh Karamizadeh
INTRODUCTION: Obesity is among the medical problems in survivors of childhood acute lymphoblastic leukemia (ALL). These patients are at risk of metabolic syndrome (MS). The present study aimed to follow the patients with ALL regarding the incidence of MS. PATIENTS AND METHODS: This study was conducted on all patients who referred to the oncology clinic from July 2012 to July 2013. The exclusion criteria of the study were ALL relapse, secondary malignancy, hypothyroidism, Down syndrome, and below 2 years of age...
April 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28898241/alterations-in-the-programming-of-energy-metabolism-in-adolescents-with-background-exposure-to-dioxins-dl-pcbs-and-pbdes
#11
Marike M Leijs, Janna G Koppe, Thomas Vulsma, Kees Olie, Wim M C van Aalderen, Pim de Voogt, Juliette Legler, Gavin W Ten Tusscher
OBJECTIVES: Dioxins and PCBs are highly toxic and persistent environmental pollutants that are measurable in humans worldwide. These persistent organic pollutants are associated with a higher incidence of diabetes mellitus. We hypothesise that perinatal (background) exposure to industrial pollutants like dioxins also influences body mass development and energy metabolism in later life. STUDY DESIGN: In The Netherlands, the perinatal exposure (prenatal exposure and postnatal lactational intake) to dioxins has been studied prospectively since 1987...
2017: PloS One
https://www.readbyqxmd.com/read/28893745/a-new-risk-locus-in-chchd5-for-hypertension-and-obesity-in-a-chinese-child-population-a-cohort-study
#12
Lijun Wu, Liwang Gao, Xiaoyuan Zhao, Meixian Zhang, Jianxin Wu, Jie Mi
OBJECTIVE: Coiled-coil-helix-coiled-coil-helix domain containing 5 (CHCHD5), a mitochondrial protein, is involved in the oxidative folding process in the mitochondrial intermembrane space. A previous study identified a hypertension-related single nucleotide polymorphism (SNP), rs3748024, in CHCHD5 in adults, but there are no reports regarding the association between CHCHD5 and obesity, which is a known risk factor for hypertension. The aim of the present study is to investigate the associations of the SNP rs3748024 with hypertension and obesity...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28817652/metabolomics-reveals-an-entanglement-of-fasting-leptin-concentrations-with-fatty-acid-oxidation-and-gluconeogenesis-in-healthy-children
#13
Franca Fabiana Kirchberg, Stephanie Brandt, Anja Moß, Wolfgang Peissner, Wolfgang Koenig, Dietrich Rothenbacher, Hermann Brenner, Berthold Koletzko, Christian Hellmuth, Martin Wabitsch
BACKGROUND: Leptin and adiponectin communicate with organ systems in order to regulate energetic and metabolic homeostasis. Their different points of action have been well characterized; however, no study has investigated their interrelationship with the metabolism at the molecular level in vivo. OBJECTIVE: To examine the associations of leptin and adiponectin with the metabolic profile reflecting the intercellular and interorgan communication as well as activated metabolic pathways...
2017: PloS One
https://www.readbyqxmd.com/read/28811937/association-between-salivary-leptin-levels-and-taste-perception-in-children
#14
Lénia Rodrigues, Rosa Espanca, Ana Rodrigues Costa, Célia Miguel Antunes, Clarinda Pomar, Fernando Capela-Silva, Cristina Conceição Pinheiro, Francisco Amado, Elsa Lamy
The satiety inducing hormone leptin acts not only at central nervous system but also at peripheral level. Leptin receptors are found in several sense related organs, including the mouth. A role of leptin in sweet taste response has been suggested but, until now, studies have been based on in vitro experiments, or in assessing the levels of the hormone in circulation. The present study investigated whether the levels of leptin in saliva are related to taste perception in children and whether Body Mass Index (BMI) affects such relationship...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/28774733/current-child-but-not-maternal-snoring-is-bi-directionally-related-to-adiposity-and-cardiometabolic-risk-markers-a-cross-sectional-and-a-prospective-cohort-analysis
#15
Olivia M Farr, Sheryl L Rifas-Shiman, Emily Oken, Elsie M Taveras, Christos S Mantzoros
PURPOSE: Obstructive sleep apnea (OSA), typically manifested as snoring, is closely associated with obesity. However, the directionality of associations of OSA with cardiometabolic risk markers is unclear, as obesity increases risk for OSA, and OSA results in excess weight gain and its metabolic consequences. Less is known about how obesity and OSA may relate in children and adolescents and whether maternal OSA may influence the development of obesity and cardiometabolic dysfunction in offspring...
November 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28771179/leptin-receptor-gene-variant-rs11804091-is-associated-with-bmi-and-insulin-resistance-in-spanish-female-obese-children-a-case-control-study
#16
Josune Olza, Azahara I Rupérez, Mercedes Gil-Campos, Rosaura Leis, Ramón Cañete, Rafael Tojo, Ángel Gil, Concepción M Aguilera
Leptin is an endocrine hormone that has a critical role in body weight homoeostasis and mediates its effects via the leptin receptor (LEPR). Common polymorphisms in the genes coding leptin receptors have been associated with metabolic abnormalities. We assessed the association of 28 LEPR polymorphisms with body mass index (BMI) and their relationship with obesity-related phenotypes, inflammation and cardiovascular disease risk biomarkers. A multicentre case-control study was conducted in 522 children (286 with obesity and 236 with normal-BMI)...
August 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28759403/metformin-for-obesity-in-prepubertal-and-pubertal-children-a-randomized-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Belén Pastor-Villaescusa, M Dolores Cañete, Javier Caballero-Villarraso, Raúl Hoyos, Miriam Latorre, Rocío Vázquez-Cobela, Julio Plaza-Díaz, José Maldonado, Gloria Bueno, Rosaura Leis, Ángel Gil, Ramón Cañete, Concepción M Aguilera
OBJECTIVES: Metformin has shown its effectiveness in treating obesity in adults. However, little research has been conducted in children, with a lack of attention on pubertal status. The objectives were to determine whether oral metformin treatment reduces BMI z score, cardiovascular risk, and inflammation biomarkers in children who are obese depending on pubertal stage and sex. METHODS: This was a randomized, prospective, double-blind, placebo-controlled, multicenter trial, stratified according to pubertal stage and sex, conducted at 4 Spanish clinical hospitals...
July 2017: Pediatrics
https://www.readbyqxmd.com/read/28749784/concentrations-of-leptin-adiponectin-and-other-metabolic-parameters-in-non-obese-children-with-down-syndrome
#18
Nikhil Tenneti, Devi Dayal, Sheetal Sharda, Inusha Panigrahi, Mohammed Didi, Savita Verma Attri, Naresh Sachdeva, Anil Kumar Bhalla
BACKGROUND: Recent data indicates that adults with Down syndrome (DS) are at increased risk for cardiovascular disease (CVD) that significantly contributes to their morbidity and mortality. Although identification of cardiometabolic risk factors during childhood is desirable to design preventive interventions, the data on such risk factors in children with DS is scarce. The aim of this study was to study the cardiometabolic risk factors such as insulin resistance (IR), leptin and adiponectin concentrations, lipid abnormalities and leptin resistance in non-obese children with DS...
August 28, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28743192/searching-for-evidence-of-an-anti-inflammatory-diet-in-children-a-systematic-review-of-randomized-controlled-trials-for-pediatric-obesity-interventions-with-a-focus-on-leptin-ghrelin-and-adiponectin
#19
Kimberly A Lewis, Sharon A Brown
PROBLEM: To address the complex phenomenon of pediatric obesity, one must understand the physiological mechanisms regulating energy intake and inflammation. The peptide hormones leptin, ghrelin, and adiponectin are involved in both, but their functions are dysregulated in obesity. The purpose of this systematic review is (1) to characterize studies of nutrition interventions for weight management in children who measure these peptides as outcomes, (2) to assess risk of bias in the studies, and (3) to determine the relationships between these peptides and body mass index (BMI)...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/28728946/serum-galectin-1-levels-are-positively-correlated-with-body-fat-and-negatively-with-fasting-glucose-in-obese-children
#20
Sezer Acar, Ahu Paketçi, Tuncay Küme, Hale Tuhan, Özlem Gürsoy Çalan, Korcan Demir, Ece Böber, Ayhan Abacı
Galectin-1, a recently identified peptide, is primarily released from the adipose tissue. Although galectin-1 was shown to have an anti-inflammatory effect, its specific function is not clearly understood. We aimed to evaluate the relationship of serum galectin-1 levels with clinical and laboratory parameters in childhood obesity. A total of 45 obese children (mean age: 12.1±3.1years) and 35 normal-weight children (mean age: 11.8±2.2years) were enrolled. Clinical [body mass index (BMI), waist circumference (WC), percentage of body fat and blood pressure] and biochemical [glucose, insulin, lipids, galectin-1, high-sensitive C-reactive protein (hsCRP) and leptin levels] parameters were assessed...
July 17, 2017: Peptides
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