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Pycnogenol

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https://www.readbyqxmd.com/read/28836883/review-on-sustained-relief-of-osteoarthritis-symptoms-with-a-proprietary-extract-from-pine-bark-pycnogenol
#1
Peter Jörg Rohdewald
The review summarizes the effects of the standardized proprietary bark extract of the French maritime pine (Pycnogenol(®)) in mild osteoarthritis (OA), stage 1 and 2. The extract exerts antioxidative, anti-inflammatory, and chondroprotective effects in vitro and in vivo. Its phenolic acids as well as catechin and taxifolin are quickly absorbed. Active metabolites, produced by gut microbiota in the intestinal tract from oligomeric procyanidins, appear in blood 6 h following ingestion and remain for at least 14 h, providing a long-lasting flow of anti-inflammatory substances for relief of OA symptoms...
August 24, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28833790/pycnogenol-cytotoxicity-in-pancreatic-ins-1e-%C3%AE-cells-induced-by-calcium-dysregulation
#2
Jana Viskupicova, Petronela Zizkova, Lucia Rackova, Lubica Horakova
Natural standardized flavonoid extract from the bark of Pinus pinaster, Pycnogenol (Pyc), was recently found to decrease intensively the activity of sarcoplasmic reticulum Ca(2+) -ATPase of rabbit skeletal muscle (SERCA1). On the basis of this inhibitory effect in a cell-free system and similarities of SERCA1 to its other isoforms, proapoptotic properties of Pyc may be expected in cellular systems. Pycnogenol (40-100 μg/mL) induced a concentration-dependent decrease of the viability of pancreatic INS-1E β cells associated with induction of apoptosis...
August 18, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28804235/management-of-varicose-veins-and-chronic-venous-insufficiency-in-a-comparative-registry-with-nine-venoactive-products-in-comparison-with-stockings
#3
G Belcaro, M Dugall, R Luzzi, M Corsi, A Ledda, A Ricci, L Pellegrini, M R Cesarone, M Hosoi, B M Errichi, U Cornelli, R Cotellese, G Agus, B Feragalli
The aim of this registry study was to compare products used to control symptoms of CVI. Endpoints of the study were microcirculation, effects on volume changes, and symptoms (analogue scale). Pycnogenol, venoruton, troxerutin, the complex diosmin-hesperidin, Antistax, Mirtoselect (bilberry), escin, and the combination Venoruton-Pycnogenol (VE-PY) were compared with compressions. No safety or tolerability problems were observed. At inclusion, measurements in the groups were comparable: 1,051 patients completed the registry...
September 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28747971/pine-bark-extract-pycnogenol%C3%A2-suppresses-cigarette-smoke-induced-fibrotic-response-via-transforming-growth-factor-%C3%AE-1-smad-family-member-2-3-signaling
#4
Je-Won Ko, Na-Rae Shin, Sung-Hyeuk Park, Joong-Sun Kim, Young-Kwon Cho, Jong-Choon Kim, In-Sik Shin, Dong-Ho Shin
Chronic obstructive pulmonary diseases (COPD) is an important disease featured as intense inflammation, protease imbalance, and air flow limitation and mainly induced by cigarette smoke (CS). In present study, we explored the effects of Pycnogenol® (PYC, pine bark extract) on pulmonary fibrosis caused by CS+lipopolysaccharide (LPS) exposure. Mice were treated with LPS intranasally on day 12 and 26, followed by CS exposure for 1 h/day (8 cigarettes per day) for 4 weeks. One hour before CS exposure, 10 and 20 mg/kg of PYC were administered by oral gavage for 4 weeks...
June 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28662519/neuroprotective-effects-of-pycnogenol-against-oxygen-glucose-deprivation-reoxygenation-induced-injury-in-primary-rat-astrocytes-via-nf-%C3%AE%C2%BAb-and-erk1-2-mapk-pathways
#5
Ruixue Xia, Chunxue Ji, Leguo Zhang
BACKGROUNDS/AIMS: Pycnogenol (PYC) is a patented mix of bioflavonoids with potent anti-oxidant and anti-inflammatory properties. In this study, we investigated the effects of PYC on oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury in primary rat astrocytes. METHODS: The primary rat astrocytes were randomly divided into 6 groups, blank control, OGD/R, OGD/R+PYC (10, 20, 40, and 60 µg/mL). The cell activity were detected by MTT and LDH assays, then the levels of oxidant products [malondialdehyde (MDA) and reactive oxygen species (ROS)] , antioxidants [superoxide dismutase (SOD)], mitochondrial membrane potential (MMP) and inflammatory cytokines were detected...
June 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28566935/variations-in-echogenicity-in-carotid-and-femoral-atherosclerotic-plaques-with-pycnogenol%C3%A2-%C3%A2-centella-asiatica-supplementation
#6
Gianni Belcaro, Umberto Cornelli
This registry study evaluated echogenicity of carotid-femoral plaques in asymptomatic subjects with increased oxidative stress and risk factors (mild hypertension, hypercholesterolemia). Supplementation with the combination Pycnogenol-CA (centella asiatica) on the echogenicity of plaques was assessed at 6 months (79 subjects). A standard management (SM) plan was used in all subjects (control of risk factors, lifestyle changes); 36 subjects used the supplements +SM; 43 SM only. The groups were comparable. High-resolution ultrasound evaluated echogenicity and plaque structure...
June 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28541356/food-and-plant-bioactives-for-reducing-cardiometabolic-disease-risk-an-evidence-based-approach
#7
REVIEW
Arrigo F G Cicero, Federica Fogacci, Alessandro Colletti
Cardiovascular diseases (CVDs) are one of the major causes of mortality and disability in Western countries. Prevention is known to be the cornerstone to lessen the incidence of CVDs and also to reduce the economic burden of both the citizen and the healthcare system. "Interventional medicine" certainly puts lifestyle modification as the first therapeutic step, including a healthy diet and physical activity. Secondly, a large body of research individuated a number of food and plant bioactives, which are potentially efficacious in preventing and reducing some highly prevalent CV risk factors, such as hypercholesterolemia, hypertension, vascular inflammation and vascular compliance...
June 21, 2017: Food & Function
https://www.readbyqxmd.com/read/28452960/distribution-of-constituents-and-metabolites-of-maritime-pine-bark-extract-pycnogenol-%C3%A2-into-serum-blood-cells-and-synovial-fluid-of-patients-with-severe-osteoarthritis-a-randomized-controlled-trial
#8
Melanie Mülek, Lothar Seefried, Franca Genest, Petra Högger
The present randomized controlled study aimed to investigate the in vivo distribution of constituents or metabolites of the standardized maritime pine bark extract Pycnogenol(®). Thirty-three patients with severe osteoarthritis scheduled for a knee arthroplasty were randomized to receive either 200 mg per day Pycnogenol(®) (P+) or no treatment (Co) over three weeks before surgery. Serum, blood cells, and synovial fluid samples were analyzed using liquid chromatography coupled to tandem mass spectrometry with electrospray ionization (LC-ESI/MS/MS)...
April 28, 2017: Nutrients
https://www.readbyqxmd.com/read/28448268/the-effect-of-pycnogenol-on-wound-healing-in-diabetic-rats
#9
Elif Dogan, Latif Yanmaz, Semin Gedikli, Ugur Ersoz, Zafer Okumus
Pycnogenol (PYC), an extract of pine bark, is known to have photoprotective, antimicrobial, antioxidant, and anti-inflammatory properties. An in vivo study was conducted to evaluate the effects of PYC treatment on wound healing in 48 adult male Sprague-Dawley rats, of which 24 were injected with a single dose of alloxan to induce diabetes. Three (3) excisional skin wounds (1.3 cm x 1.3 cm x 2 mm) were created in each healthy and diabetic animal. One (1) wound in each animal was left untreated, 1 was treated daily with a cleanser (ethacridine lactate) and covered with silver sulfadiazine (SSD), and 1 was treated with PYC powder (30 mg)...
April 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28351412/effect-of-pycnogenol%C3%A2-on-attention-deficit-hyperactivity-disorder-adhd-study-protocol-for-a-randomised-controlled-trial
#10
Annelies A J Verlaet, Berten Ceulemans, Helene Verhelst, Dirk Van West, Tess De Bruyne, Luc Pieters, Huub F J Savelkoul, Nina Hermans
BACKGROUND: Methylphenidate (MPH), the first choice medication for attention-deficit hyperactivity disorder (ADHD), is associated with serious adverse effects like arrhythmia. Evidence on the association of ADHD with immune and oxidant-antioxidant imbalances offers potential for antioxidant and/or immunomodulatory nutritional supplements as ADHD therapy. One small randomised trial in ADHD suggests, despite various limitations, therapeutic benefit from Pycnogenol®, a herbal, polyphenol-rich extract...
March 28, 2017: Trials
https://www.readbyqxmd.com/read/28255210/postpartum-varicose-veins-supplementation-with-pycnogenol-or-elastic-compression-a-12-month-follow-up
#11
Gianni Belcaro, Mark Dugall, Roberta Luzzi, Edmondo Ippolito, M Rosaria Cesarone
This open registry aimed to evaluate the clinical evolution of postpartum varicose veins (VVs), in healthy women after the second pregnancy, how these veins regain shape and competence, and possible treatments. The registry included two groups of women: (1) those who used elastic compression stockings, and (2) who used an oral venotonic agent (Pycnogenol, 100 mg/d). A total of 12 evaluation targets were established. Minor symptoms were scored in an analogue scale line. A visual analogue scale line evaluated the overall satisfaction relative to elastic compression or Pycnogenol...
March 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28178874/ameliorative-effects-of-pine-bark-extract-on-cisplatin-induced-acute-kidney-injury-in-rats
#12
In-Chul Lee, Je-Won Ko, Sung-Hyeuk Park, Na-Rae Shin, In-Sik Shin, Yun-Bae Kim, Jong-Choon Kim
OBJECTIVE: This study investigated the dose-response effects of pine bark extract (PBE, pycnogenol(®)) on oxidative stress-mediated apoptotic changes induced by cisplatin (Csp) in rats. MATERIALS AND METHODS: The ameliorating potential of PBE was evaluated after orally administering PBE at doses of 10 or 20 mg/kg for 10 days. Acute kidney injury was induced by a single intraperitoneal injection of Csp at 7 mg/kg on test day 5. RESULTS: Csp treatment caused acute kidney injury manifested by elevated levels of serum blood urea nitrogen (BUN) and creatinine (CRE) with corresponding histopathological changes, including degeneration of tubular epithelial cells, hyaline casts in the tubular lumen, and inflammatory cell infiltration (interstitial nephritis)...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28116886/normalization-of-cardiovascular-risk-factors-in-peri-menopausal-women-with-pycnogenol%C3%A2
#13
Roberta Luzzi, Gianni Belcaro, Morio Hosoi, Beatrice Feragalli, Umberto Cornelli, Mark Dugall, Andrea Ledda
BACKGROUND: The aim of the study was the evaluation of the efficacy of Pycnogenol® in peri-menopausal women in controlling homocysteine and C-reactive protein (CRP) levels, borderline cardiovascular risk factors, oxidative stress (OS) and symptoms associated to menopausal transition (MT). METHODS: Pycnogenol®, 100mg/day, was used as a supplement for 8 weeks by a group of 35 women. A comparable group of 35 women with identical cardiovascular risk factors was included as the control group...
February 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28053897/effects-of-a-supplement-combining-pycnogenol-%C3%A2-and-l-arginine-aspartate-on-lower-urinary-dysfunction-compared-with-saw-palmetto-extract
#14
Hiroshi Yagi, Ryo Sato, Kojiro Nishio, Gaku Arai, Shigehiro Soh, Hiroshi Okada
OBJECTIVES: Lower urinary tract symptoms (LUTS) and sexual dysfunction (SDys) are common problems that affect quality of life (QOL) in elderly men. In addition to prescribed drugs, many over-the-counter medications including supplements are used to treat QOL diseases. Phosphodiesterase inhibitors are reported to be effective for both LUTS and SDys by increasing nitric oxide levels. French maritime pine bark extract Pycnogenol(®), which is a potent nitric oxide donor, is reported to be effective for SDys...
January 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/27994914/inhibitory-effect-of-pycnogenol-%C3%A2-on-airway-inflammation-in-ovalbumin-induced-allergic-rhinitis
#15
Ceren Günel, Buket Demirci, Aylin Eryılmaz, Mustafa Yılmaz, İbrahim Meteoğlu, İmran Kurt Ömürlü, Yeşim Başal
BACKGROUND: The supplement Pycnogenol(®) (PYC) has been used for the treatment of several chronic diseases including allergic rhinitis (AR). However, the in vivo effects on allergic inflammation have not been identified to date. AIMS: To investigate the treatment results of PYC on allergic inflammation in a rat model of allergic rhinitis. STUDY DESIGN: Animal experimentation. METHODS: Allergic rhinitis was stimulated in 42 rats by intraperitoneal sensitization and intranasal challenge with Ovalbumin...
November 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27777890/supplementing-conventional-treatment-with-pycnogenol%C3%A2-may-improve-hepatitis-c-virus-associated-type-2-diabetes-a-mini-review
#16
REVIEW
Sayeh Ezzikouri, Fatima Zahra Jadid, Salsabil Hamdi, Lahcen Wakrim, Kyoko Tsukiyama-Kohara, Soumaya Benjelloun
Hepatitis C virus (HCV) infection and type 2 diabetes mellitus (T2DM) present a significant health burden, with increasing complications and mortality rates worldwide. Pycnogenol® (PYC), a natural product, possesses antidiabetic and antiviral properties that may improve HCV-associated T2DM. In this review, we present previously published data on the effectiveness of PYC against HCV replication and T2DM. We believe that supplementing conventional treatment with PYC may improve the current HCV therapy, attenuate HCV-associated T2DM, and reduce the risk of complications such as cirrhosis or hepatocellular carcinoma and cardiovascular disease...
September 28, 2016: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/27737807/cognitive-assessment-of-pycnogenol-therapy-following-traumatic-brain-injury
#17
Stephen W Scheff, Kelly N Roberts
We have previously shown that pycnogenol (PYC) increases antioxidants, decreases oxidative stress, suppresses neuroinflammation and enhances synaptic plasticity following traumatic brain injury (TBI). Here, we investigate the effects of PYC on cognitive function following a controlled cortical impact (CCI). Adult Sprague-Dawley rats received a CCI injury followed by an intraperitoneal injection of PYC (50 or 100mg/kg). Seven days post trauma, subjects were evaluated in a Morris water maze (MWM) and evaluated for changes in lesion volume...
November 10, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27725237/a-standardized-bark-extract-of-pinus-pinaster-aiton-pycnogenol-%C3%A2-attenuated-chronic-obstructive-pulmonary-disease-via-erk-sp1-signaling-pathway
#18
Na-Rae Shin, Hyung-Won Ryu, Je-Won Ko, Ji-Won Park, Ok-Kyoung Kwon, Sei-Ryang Oh, Jong-Choon Kim, In-Sik Shin, Kyung-Seop Ahn
ETHNOPHARMACOLOGICAL RELEVANCE: A standardized bark extract of Pinus pinaster Aiton (Pycnogenol(®); PYC) used as an herbal medicine to treat various diseases in Europe and North America. AIM OF THE STUDY: This study evaluates the ability of PYC to inhibit chronic obstructive pulmonary disease (COPD) in the cigarette smoke extract (CSE)-stimulated human airway epithelial cell line NCI-H292 and in a cigarette smoke (CS) and lipopolysaccharide (LPS)-induced mouse model...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27643741/pycnogenol-ameliorates-asthmatic-airway-inflammation-and-inhibits-the-function-of-goblet-cells
#19
Zhaoe Liu, Bo Han, Xing Chen, Qiaoling Wu, Lijun Wang, Gang Li
Pycnogenol(®) (PYC) is utilized in the treatment of various diseases ranging from chronic inflammation to circulatory diseases, but its efficacy and functional mechanism in pediatric asthma continue to remain obscure. Therefore, the purpose of this study was to investigate the effectiveness and molecular mechanism of PYC on regulation of asthmatic airway inflammation. We found that PYC with tail intravenous injection of 50 mg/kg or intragastric administration of 100 mg/kg all reduced ovalbumin (OVA)-induced airway injury...
November 2016: DNA and Cell Biology
https://www.readbyqxmd.com/read/27521821/effect-of-pycnogenol-on-the-healing-of-venous-ulcers
#20
RANDOMIZED CONTROLLED TRIAL
Renato Riera Toledo, Maria Elisabeth Rennó de Castro Santos, Taylor Brandão Schnaider
BACKGROUND: Venous ulcers are common complications of chronic venous insufficiency that result in severe physical and mental suffering to patients. The oral administration of diosmin/hesperidin has been used as adjuvant therapy in the treatment of chronic venous insufficiency. The purpose of this study was to evaluate and compare the effect of pycnogenol and diosmin/hesperidin on the healing of venous ulcers. METHODS: This longitudinal, prospective, randomized clinical trial was conducted with 30 adult patients with venous ulcers from a vascular surgery outpatient clinic of a university hospital...
January 2017: Annals of Vascular Surgery
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