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Stephen W Scheff, Kelly N Roberts
We have previously shown that pycnogenol (PYC) increases antioxidants, decreases oxidative stress, suppresses neuroinflammation and enhances synaptic plasticity following traumatic brain injury (TBI). Here, we investigate the effects of PYC on cognitive function following a controlled cortical impact (CCI). Adult Sprague-Dawley rats received a CCI injury followed by an intraperitoneal injection of PYC (50 or 100mg/kg). Seven days post trauma, subjects were evaluated in a Morris water maze (MWM) and evaluated for changes in lesion volume...
October 10, 2016: Neuroscience Letters
Na-Rae Shin, Hyung-Won Ryu, Je-Won Ko, Ji-Won Park, Ok-Kyoung Kwon, Sei-Ryang Oh, Jong-Choon Kim, In-Sik Shin, Kyung-Seop Ahn
ETHNOPHARMACOLOGICAL RELEVANCE: A standardized bark extract of Pinus pinaster Aiton (Pycnogenol(®); PYC) used as an herbal medicine to treat various diseases in Europe and North America. AIM OF THE STUDY: This study evaluates the ability of PYC to inhibit chronic obstructive pulmonary disease (COPD) in the cigarette smoke extract (CSE)-stimulated human airway epithelial cell line NCI-H292 and in a cigarette smoke (CS) and lipopolysaccharide (LPS)-induced mouse model...
October 7, 2016: Journal of Ethnopharmacology
Zhaoe Liu, Bo Han, Xing Chen, Qiaoling Wu, Lijun Wang, Gang Li
Pycnogenol(®) (PYC) is utilized in the treatment of various diseases ranging from chronic inflammation to circulatory diseases, but its efficacy and functional mechanism in pediatric asthma continue to remain obscure. Therefore, the purpose of this study was to investigate the effectiveness and molecular mechanism of PYC on regulation of asthmatic airway inflammation. We found that PYC with tail intravenous injection of 50 mg/kg or intragastric administration of 100 mg/kg all reduced ovalbumin (OVA)-induced airway injury...
September 19, 2016: DNA and Cell Biology
Renato Riera Toledo, Maria Elisabeth Rennó de Castro Santos, Taylor Brandão Schnaider
BACKGROUND: Venous ulcers are common complications of chronic venous insufficiency that result in severe physical and mental suffering to patients. The oral administration of diosmin/hesperidin has been used as adjuvant therapy in the treatment of chronic venous insufficiency. The purpose of this study was to evaluate and compare the effect of pycnogenol and diosmin/hesperidin on the healing of venous ulcers. METHODS: This longitudinal, prospective, randomized clinical trial was conducted with 30 adult patients with venous ulcers from a vascular surgery outpatient clinic of a university hospital...
August 10, 2016: Annals of Vascular Surgery
Stephanie Maxine Ross
No abstract text is available yet for this article.
September 2016: Holistic Nursing Practice
Rui Liu, Bin Fan, Huiying Cong, Shoichiro Ikuyama, Haixia Guan, Jianqiu Gu
Pycnogenol (PYC) is an extract from French maritime pine bark. Its anti-oxidative and anti-inflammatory effects have been shown to be beneficial for atherosclerosis. Here, we tested whether PYC could suppress high cholesterol and fat diet (HCD)-induced atherosclerosis formation in apolipoprotein E (apoE)-deficient mice. In our study, PYC suppressed oxidized low-density lipoprotein (ox-LDL)-induced lipid accumulation in peritoneal macrophages. ApoE-deficient mice were orally administered PYC or a control solvent for ten weeks, and these mice were fed a standard diet or HCD during the latter 8 weeks...
June 16, 2016: Journal of Cardiovascular Pharmacology
Naglaa A Bayomy, Eman Z Abdelaziz, Mona A Said, Marwa S Badawi, Reda H El-Bakary
Vancomycin-induced nephrotoxicity has been reported to occur in 5%-25% of patients who were administered with it. Several natural antioxidants were found to be effective against drug-induced toxicity. We evaluated the possible protective effects of spirulina and pycnogenol alone or in combination on vancomycin-induced renal cortical oxidative stress. Forty-nine rats were randomly divided into 7 groups: group I, control; group II, received spirulina 1000 mg/kg per day; group III, received pycnogenol 200 mg/kg per day; group IV, received vancomycin 200 mg/kg per day every 12 h; group V, (spirulina + vancomycin); group VI, (pycnogenol + vancomycin); and group VII, (pycnogenol + spirulina + vancomycin)...
August 2016: Canadian Journal of Physiology and Pharmacology
Stanislava Jankyova, Dominika Rubintova, Lenka Janosikova, Peter Panek, Tatiana Foltanova, Eva Kralova
The progression of diabetes mellitus leads in time to the development of serious cardiovascular complications. Pycnogenol® (PYC) belongs to strong antioxidants that may interfere with different pathways playing an important role in diseases associated with oxidative stress. Metformin (MET), commonly used antidiabetic drug, has cardio-protective effects via activation of AMP kinase (AMPK). In our study, we examined the effects of PYC as add-on drug to metformin therapy in streptozotocin (STZ)-induced diabetic rats...
August 2016: Phytotherapy Research: PTR
Aylin Eryilmaz, Nuket Eliyatkin, Buket Demirci, Yesim Basal, Imran Kurt Omurlu, Ceren Gunel, Safiye Aktas, Ali Toka, Sema Basak
CONTEXT: Pycnogenol(®), which is French maritime pine bark extract, is a potent antioxidant. It is used in medical conditions caused by oxidative stress. Cisplatin (cis-diamminedichloroplatinum II) is an antineoplastic agent. However, its serious side effects such as ototoxicity limit its usage. OBJECTIVE: Antioxidants can be used to prevent ototoxicity. We investigated the effect of Pycnogenol(®) on cisplatin-induced ototoxicity. MATERIALS AND METHODS: Rats were randomly assigned to four groups of five...
May 9, 2016: Pharmaceutical Biology
In-Hyoung Yang, Ji-Ae Shin, Lee-Han Kim, Ki Han Kwon, Sung-Dae Cho
In the present study, the apoptotic effect of pycnogenol and its molecular mechanism in human oral squamous cell carcinoma HSC-3 cells were investigated. Pycnogenol significantly inhibited the viability of HSC-3 cells and suppressed neoplastic cell transformation in HSC-3 cells and TPA-treated JB6 cells. It caused caspase-dependent apoptosis evidenced by the increase in cleaved poly (ADP-ribose) polymerase and caspase 3 in a dose-dependent manner. Pycnogenol increased Bak protein by enhancing its protein stability whereas other Bcl-2 family members were not altered...
January 2016: Journal of Clinical Biochemistry and Nutrition
Gianni Belcaro
This 8-week registry study was a comparative evaluation of Pycnogenol (French Maritime Pine Bark extract; Horphag Research, Geneva) and Antistax (grape leaf extract [GLE, Boehringer Ingelheim, Germany]) in controlling symptoms of chronic venous insufficiency (CVI). "Standard management" for CVI is compression; a group of comparable subjects was monitored to evaluate the effects of stockings. The registry included 183 patients (166 completing). Supplementation with Antistax (two tablets of 360 mg/d) or Pycnogenol (100 mg/d) was used...
December 2015: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
G Belcaro, M Dugall, E Ippolito, S Hu, A Saggino, B Feragalli
AIM: This 12-month product registry study evaluated the effects of supplementation with French pine bark extract (Pycnogenol(®)) on cognitive function, attention, and mental performance in healthy subjects with high oxidative stress. METHODS: Healthy subjects (age range 55-70) were screened - within a cardiovascular screening program - for oxidative stress. Out of 150 subjects, high oxidative stress was present in 44; the use of the supplement Pycnogenol(®) was suggested (100 mg/day)...
December 2015: Journal of Neurosurgical Sciences
Christopher M Norris, Pradoldej Sompol, Kelly N Roberts, Mubeen Ansari, Stephen W Scheff
Pycnogenol (PYC) is a patented mix of bioflavonoids with potent anti-oxidant and anti-inflammatory properties. Previously, we showed that PYC administration to rats within hours after a controlled cortical impact (CCI) injury significantly protects against the loss of several synaptic proteins in the hippocampus. Here, we investigated the effects of PYC on CA3-CA1 synaptic function following CCI. Adult Sprague-Dawley rats received an ipsilateral CCI injury followed 15 min later by intravenous injection of saline vehicle or PYC (10 mg/kg)...
February 2016: Experimental Neurology
G Belcaro, M Dugall, E Ippolito, M Hosoi, U Cornelli, A Ledda, M Scoccianti, M R Cesarone, L Pellegrini, R Luzzi, M Corsi
: The aim of the study was to evaluate the effect of the nutritional supplements Pycnogenol and Centella Asiatica (CA) on atherosclerosis progression in low-risk, asymptomatic subjects with carotid or femoral stenosing plaques. METHODS: The study included subjects aged 45-60 with stenosing atherosclerotic plaques (>50- 60%) in at least one carotid or common femoral bifurcation. Subjects were allocated into 3 groups: Group 1 (controls): management was based on education, exercise, diet and lifestyle changes...
October 27, 2015: Minerva Cardioangiologica
Hong Luo, Jing Wang, Chenhui Qiao, Ning Ma, Donghai Liu, Weihua Zhang
Atherosclerosis is a leading cause of death worldwide and is characterized by lipid-laden foam cell formation. Recently, pycnogenol (PYC) has drawn much attention because of its prominent effect on cardiovascular disease (CVD). However, its protective effect against atherosclerosis and the underlying mechanism remains undefined. Here PYC treatment reduced areas of plaque and lipid deposition in atherosclerotic mice, concomitant with decreases in total cholesterol and triglyceride levels and increases in HDL cholesterol levels, indicating a potential antiatherosclerotic effect of PYC through the regulation of lipid levels...
2015: Experimental & Molecular Medicine
Susanne Grether-Beck, Alessandra Marini, Thomas Jaenicke, Jean Krutmann
Nutritional strategies to benefit skin health are of growing importance. Current approaches mainly involve nutritional supplements containing antioxidants which were initially designed to protect human skin against ultraviolet radiation-induced damage. Within recent years, however, a growing number of studies suggests that the beneficial effects of these products clearly extend beyond photoprotection. In this review we take the nutritional supplement Pycnogenol®, which is based on an extract prepared from French marine pine bark extract, as an example to illustrate this development...
2016: Skin Pharmacology and Physiology
Yoshitomo Kobori, Keisuke Suzuki, Toshiyuki Iwahata, Takeshi Shin, Yuko Sadaoka, Ryo Sato, Kojiro Nishio, Hiroshi Yagi, Gaku Arai, Shigehiro Soh, Hiroshi Okada, Jeffry Michael Strong, Peter Rohdewald
We evaluated the effectiveness of antioxidant co-supplementation therapy using Larginine and Pycnogenol(®) in Japanese men with oligoasthenozoospermia and mild erectile dysfunction (ED). A total of forty-seven adult males with oligoasthenoteratozoospermia syndrome (OAT) were eligible for enrollment. The effectiveness of supplementation with a combination of L-arginine 690 mg and French maritime pine bark extract (Pycnogenol(®)) 60mg for OAT and ED was investigated. The sperm concentration was enhanced significantly after treatment 2 and 4 months (11...
September 2015: Archivio Italiano di Urologia, Andrologia
Gangyong Huang, Jianguo Wu, Siqun Wang, Yibing Wei, Feiyan Chen, Jie Chen, Jingsheng Shi, Jun Xia
CONTEXT: Pycnogenol(®) extracted from French maritime pine bark (Pinus pinaster Ait. subsp. atlantica) is functional for its antioxidant activity. OBJECTIVE: To investigate the effects of Pycnogenol(®) on bone mineral density (BMD), trabecular microarchitecture and bone metabolism in ovariectomized (OVX) rats. MATERIALS AND METHODS: Thirty Sprague-Dawley rats were randomized into 3 groups: SHAM group (sham-operated rats), OVX group (OVX rats), and treatment group (OVX rats supplemented with 40 mg/kg Pycnogenol(®) by oral gavage)...
2015: International Journal of Clinical and Experimental Medicine
Bin Fan, Sai-Hong Dun, Jian-Qiu Gu, Yang Guo, Shoichiro Ikuyama
Over activation of microglia results in the production of proinflammatory agents that have been implicated in various brain diseases. Pycnogenol is a patented extract from French maritime pine bark (Pinus pinaster Aiton) with strong antioxidant and anti-inflammatory potency. The present study investigated whether pycnogenol may be associated with the production of proinflammatory mediators in lipopolysaccharide-stimulated BV2 (mouse-derived) microglia. It was found that pycnogenol treatment was dose-dependently associated with significantly less release of nitricoxide (NO), TNF-α, IL-6 and IL-1β, and lower levels of intercellular adhesion molecule1 (ICAM-1) and perilipin 2 (PLIN2)...
2015: PloS One
Bo Gao, Chongwang Chang, Jie Zhou, Tianzhi Zhao, Chao Wang, Chen Li, Guodong Gao
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by dopaminergic neurons degeneration and oxidative damage may underlie this process. However, there are still no efficient drugs to cure the disease. Pycnogenol (PYC) isolated from the procyanidin-rich French maritime pine (Pinus maritime) bark has shown various antioxidant activities in previous studies. In this study, we explored its effect against rotenone (Rot)-induced neurotoxicity and the underlying mechanisms in PC12 cells...
October 2015: DNA and Cell Biology
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