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International ovarian tumor analysis

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https://www.readbyqxmd.com/read/29324538/specific-regions-rather-than-the-entire-peritoneal-carcinosis-index-are-predictive-of-complete-resection-and-survival-in-advanced-epithelial-ovarian-cancer
#1
Mikkel Rosendahl, Philipp Harter, Signe Frahm Bjørn, Claus Høgdall
BACKGROUND: Advanced epithelial ovarian cancer (EOC) often involves the peritoneum. Because complete resection of tumor and carcinosis is the most important prognostic factor, the peritoneal carcinosis index (PCI) has been evaluated in EOC. We hypothesize that specific PCI regions comprising the small intestine with mesentery (regions 9-12) and the hepatoduodenal ligament (region 2) are more predictive of complete resection (R = 0) and survival than the entire PCI. MATERIALS AND METHODS: We analyzed prospectively collected nationwide data from 507 patients with International Federation of Gynecology and Obstetrics stage IIIB to IVB EOC who underwent primary surgery with complete cytoreductive intent...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29324534/reproductive-outcomes-after-gestational-trophoblastic-neoplasia-a-comparison-between-single-agent-and-multiagent-chemotherapy-retrospective-analysis-from-the-mito-9-group
#2
Raffaella Cioffi, Alice Bergamini, Angiolo Gadducci, Gennaro Cormio, Veronica Giorgione, Micaela Petrone, Emanuela Rabaiotti, Francesca Pella, Massimo Candiani, Giorgia Mangili
OBJECTIVES: Gestational trophoblastic neoplasia affects women of reproductive age and is usually treated by chemotherapy. Major concerns related to chemotherapy in young women are the possible infertility, risk of early menopause, and teratogenic effects on subsequent pregnancies. The study's aim was to analyze menstrual and reproductive outcomes of women treated with single-agent versus multiagent chemotherapy for gestational trophoblastic neoplasia. METHODS: One-hundred fifty-one patients were treated...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29324532/low-expression-of-protocadherin-8-promotes-the-progression-of-ovarian-cancer
#3
Yuan Cao, Yan Yu, Xiaolong Chen, Fang Ren, Ruitao Zhang, Yanyan Jia, Zhigang Ren, Ranran Sun, Juan Li, Huirong Shi
OBJECTIVE: Ovarian cancer (OC) is the second most lethal gynecological cancer among women throughout the world. Protocadherin-8 (PCDH8) could function as a candidate tumor suppressor. However, the link between PCDH8 and OC development is poorly understood. MATERIALS AND METHODS: A total of 68 OC patients were retrospectively enrolled. Clinical information was collected and cancer tissues were used for tissue microarray. The PCDH8 expression was determined on tissue microarray by immunohistochemical staining, and PCDH8 protein was detected in cancer tissues and adjacent tissue by western blotting...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29250192/creb5-promotes-tumor-cell-invasion-and-correlates-with-poor-prognosis-in-epithelial-ovarian-cancer
#4
Shanyang He, Yalan Deng, Yanbin Liao, Xiaojin Li, Jun Liu, Shuzhong Yao
CAMP responsive element binding protein 5 (CREB5) has crucial roles in regulating cell growth, proliferation, differentiation and cell cycle regulation. CREB5 has been identified to be overexpressed in several types of human cancer. However, the expression characteristics of CREB5 in epithelial ovarian cancer remains unknown, and its potential clinical prognostic significance has not yet been elucidated. In the present study, quantitative polymerase chain reaction (qPCR) and western blot analysis were performed to detect CREB5 mRNA and protein expression levels in 10 fresh tissue and cell lines epithelial ovarian cancer...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29248013/fertility-sparing-surgery-in-advanced-stage-malignant-ovarian-germ-cell-tumor-a-case-report
#5
Montassar Ghalleb, Hatem Bouzaiene, Skander Slim, Achraf Hadiji, Monia Hechiche, Jamel Ben Hassouna, Khaled Rahal
BACKGROUND: Malignant ovarian germ cell tumor is a rare type of disease, which generally has a good prognosis due to the high chemosensitivity of this type of tumor. Fertility preservation is an important issue because malignant ovarian germ cell tumor commonly affects young women. Although conservation is the standard for early stage, it becomes more debatable as the disease progresses to more advanced stages. AIM: Report the case of a patient with an International Federation of Gynecology and Obstetrics Stage IIIc malignant ovarian germ cell tumor, who had conservative surgery and chemotherapy with a good fertility outcome...
December 17, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29242280/results-of-fertility-sparing-surgery-for-expansile-and-infiltrative-mucinous-ovarian-cancers
#6
Sebastien Gouy, Marine Saidani, Amandine Maulard, Slim Bach-Hamba, Enrica Bentivegna, Alexandra Leary, Patricia Pautier, Mojgan Devouassoux-Shisheboran, Catherine Genestie, Philippe Morice
BACKGROUND: No series had been reported focusing on the results of fertility-sparing surgery in stage I mucinous ovarian cancers according to histotype (infiltrative vs. expansile). Investigating such outcomes was the aim of the present study. MATERIALS AND METHODS: The present study was a retrospective analysis of patients treated conservatively with preservation of the uterus and contralateral ovary from 1976 to 2016. The pathology of the tumors was reviewed by two expert pathologists according to the 2014 World Health Organization (WHO) classification criteria...
December 14, 2017: Oncologist
https://www.readbyqxmd.com/read/29236181/ultrasound-based-logistic-regression-model-lr2-versus-magnetic-resonance-imaging-for-discriminating-between-benign-and-malignant-adnexal-masses-a-prospective-study
#7
Kanane Shimada, Koji Matsumoto, Takashi Mimura, Tetsuya Ishikawa, Jiro Munechika, Yoshimitsu Ohgiya, Miki Kushima, Yusuke Hirose, Yuka Asami, Chiaki Iitsuka, Shingo Miyamoto, Mamiko Onuki, Hajime Tsunoda, Ryu Matsuoka, Kiyotake Ichizuka, Akihiko Sekizawa
BACKGROUND: The diagnostic performances of the International Ovarian Tumor Analysis (IOTA) ultrasound-based logistic regression model (LR2) and magnetic resonance imaging (MRI) in discriminating between benign and malignant adnexal masses have not been directly compared in a single study. METHODS: Using the IOTA LR2 model and subjective interpretation of MRI findings by experienced radiologists, 265 consecutive patients with adnexal masses were preoperatively evaluated in two hospitals between February 2014 and December 2015...
December 13, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29194193/clinical-predictors-of-recurrence-and-prognostic-value-of-lymph-node-involvement-in-the-serous-borderline-ovarian-tumor
#8
Xue-Qian Qian, Xiao-Ping Hua, Juan-Hong Wu, Yuan-Ming Shen, Xiao-Dong Cheng, Xiao-Yun Wan
AIM: This study was aimed to evaluate the risk factors of recurrence and the value of nodal involvement in patients with serous borderline ovarian tumors (SBOT). METHODS: Two hundred twenty-five patients who underwent surgery and were diagnosed with SBOT were retrospectively studied. Univariate and multivariate analyses were used to assess the risk factors for recurrence. Patients' clinical pathologic characteristics were compared between the patients who presented lymph node involvement and those who did not...
November 30, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29194189/ovarian-yolk-sac-tumors-does-age-matter
#9
Cecile Faure Conter, Caihong Xia, David Gershenson, Jean Hurteau, Al Covens, Farzana Pashankar, Mark Krailo, Deborah Billmire, Catherine Patte, Brice Fresneau, Furqan Shaikh, Sara Stoneham, James Nicholson, Matthew Murray, Anne Lindsay Frazier
BACKGROUND: Whereas among pediatric oncologists, ovarian yolk sac tumor (O-YST) is considered a chemosensitive tumor, it is often cited as an adverse prognostic factor in adult women with ovarian germ cell tumors. METHODS: The Malignant Germ Cell International Consortium data set included 6 pediatric clinical trials (United States, United Kingdom, and France) and 2 adult gynecology clinical trials (United States). Any patient with an O-YST that was International Federation of Gynecology and Obstetrics stage IC or higher and treated with a platinum-based chemotherapy was eligible...
November 30, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29185271/prognostic-significance-of-normal-sized-ovary-in-advanced-serous-epithelial-ovarian-cancer
#10
E Sun Paik, Ji Hye Kim, Tae Joong Kim, Jeong Won Lee, Byoung Gie Kim, Duk Soo Bae, Chel Hun Choi
OBJECTIVE: We compared survival outcomes of advanced serous type epithelial ovarian cancer (EOC) patients with normal-sized ovaries and enlarged-ovarian tumors by propensity score matching analysis. METHODS: The medical records of EOC patients treated at Samsung Medical Center between 2002 and 2015 were reviewed retrospectively. We investigated EOC patients with high grade serous type histology and International Federation of Gynecology and Obstetrics (FIGO) stage IIIB, IIIC, or IV who underwent primary debulking surgery (PDS) and adjuvant chemotherapy to identify patients with normal-sized ovaries...
January 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29184867/comorbidity-of-gynecological-and-non-gynecological-diseases-with-adenomyosis-and-endometriosis
#11
Eun Ji Choi, Seong Beom Cho, Sa Ra Lee, Young Mi Lim, Kyungah Jeong, Hye-Sung Moon, Hyewon Chung
Objective: Adenomyosis and endometriosis are relatively common gynecological diseases that exhibit many common features. This study identified gynecological and non-gynecological diseases that exhibited comorbidity with adenomyosis and endometriosis in Korean women. Methods: We used Health Insurance Review and Assessment data from 2009 to 2011 and searched for adenomyosis and endometriosis (coded as N80.1 and D25 in International Classification of Disease, 10th revision [ICD-10], respectively)...
November 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29119698/differences-in-the-ultrasound-features-of-papillations-in-unilocular-solid-adnexal-cysts-a-retrospective-international-multicenter-study
#12
Chiara Landolfo, Lil Valentin, Dorella Franchi, Caroline Van Holsbeke, Robert Fruscio, Wouter Froyman, Povilas Sladkevicius, Jeroen Kaijser, Lieveke Ameye, Tom Bourne, Luca Savelli, An Coosemans, Antonia Testa, Dirk Timmerman
OBJECTIVES: The aim is to determine if there are any ultrasound features of papillations or of the cyst wall that can discriminate between benign and malignant unilocular-solid cysts with papillations but no other solid components. METHODS: Patients with an adnexal lesion described at ultrasonography as unilocular-solid with papillations but no other solid components were identified from the International Ovarian Tumor Analysis (IOTA) database derived from seven ultrasound centers...
November 8, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29113377/an-updated-meta-analysis-of-the-prognostic-value-of-decreased-e-cadherin-expression-in-ovarian-cancer
#13
LiLi Yu, Xiaoli Hua, Yu Yang, Ke Li, Qilin Zhang, Lixiu Yu
Decreased epithelial cadherin (E-cadherin) expression is hypothesized to be related to poor prognosis of ovarian cancer, but the predictive value is still inconsistent. We conducted an updated meta-analysis with a total of 16 studies enrolling 1720 patients to estimate the prognostic value of decreased E-cadherin expression in ovarian cancer. Reduced expression of E-cadherin was significantly associated to poor overall survival (HR = 1.74, 95% CI: 1.40-2.17) and progression-free survival (HR = 1.45, 95% CI: 1...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29113220/pax8-is-a-potential-marker-for-the-diagnosis-of-primary-epithelial-ovarian-cancer
#14
Hong-Juan Chai, Qing Ren, Qin Fan, Liu Ye, Guang-Ye Du, Hua-Wen Du, Wei Xu, Yue Li, Lan Zhang, Zhong-Ping Cheng
The present study aimed to investigate the clinical significance of paired-box 8 (PAX8) in primary epithelial ovarian cancer (PEOC). Using immunohistochemical (IHC) staining, the expression of PAX8 in 60 patients with PEOC, 20 patients with ovarian benign lesions and 10 patients with metastatic ovarian cancer (MOC), was examined based on the clinicopathological profiles of the patients. The correlation between PAX8 expression and the clinicopathological parameters or prognosis of patients was statistically analyzed...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29039517/microrna%C3%A2-455-inhibits-cell-proliferation-and-invasion-of-epithelial-ovarian-cancer-by-directly-targeting-notch1
#15
Lixia Xu, Haiyan Li, Lei Su, Qian Lu, Zhenfeng Liu
Ovarian cancer (OC) is the fifth leading cause of cancer‑associated mortality among women in developed countries. Numerous microRNAs are aberrantly expressed in epithelial (E) OC, and are involved in EOC formation and progression. As such, microRNAs may be investigated as diagnostic and prognostic molecular biomarkers, and therapeutic targets for patients with EOC. For instance, microRNA‑455 (miR‑455) is abnormally expressed in various types of human cancer. However, details on the expression level, biological roles and underlying mechanism of miR‑455 in EOC remain unclear...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28969913/genetic-predisposition-to-bevacizumab-induced-hypertension
#16
Melissa K Frey, Fanny Dao, Narciso Olvera, Jason A Konner, Maura N Dickler, Douglas A Levine
OBJECTIVE: Bevacizumab, a monoclonal antibody to VEGF, has shown efficacy in ovarian, cervical and endometrial cancer in addition to several other solid tumors. Serious side effects include hypertension, proteinuria, bowel perforation, and thrombosis. We tested the hypothesis that genetic variation in hypertension-associated genes is associated with bevacizumab-induced hypertension (BIH). METHODS: Patients with solid tumors treated with bevacizumab in combination with other therapy were identified from six clinical trials...
September 29, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28834973/simple-rules-not-so-simple-the-use-of-international-ovarian-tumor-analysis-iota-terminology-and-simple-rules-in-inexperienced-hands-in-a-prospective-multicenter-cohort-study
#17
Evelyne Meys, Iris Rutten, Roy Kruitwagen, Brigitte Slangen, Sandrina Lambrechts, Helen Mertens, Ernst Nolting, Dieuwke Boskamp, Toon Van Gorp
Objectives To analyze how well untrained examiners - without experience in the use of International Ovarian Tumor Analysis (IOTA) terminology or simple ultrasound-based rules (simple rules) - are able to apply IOTA terminology and simple rules and to assess the level of agreement between non-experts and an expert. Methods This prospective multicenter cohort study enrolled women with ovarian masses. Ultrasound was performed by non-expert examiners and an expert. Ultrasound features were recorded using IOTA nomenclature, and used for classifying the mass by simple rules...
August 23, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/28830009/humanization-of-jaa-f11-a-highly-specific-anti-thomsen-friedenreich-pancarcinoma-antibody-and-invitro-efficacy-analysis
#18
Swetha Tati, John C Fisk, Julia Abdullah, Loukia Karacosta, Taylor Chrisikos, Padraic Philbin, Susan Morey, Diala Ghazal, Fatma Zazala, Joseph Jessee, Sally Quataert, Stephen Koury, David Moreno, Jing Ying Eng, Vladislav V Glinsky, Olga V Glinskii, Muctarr Sesay, Anthony W Gebhard, Karamveer Birthare, James R Olson, Kate Rittenhouse-Olson
JAA-F11 is a highly specific mouse monoclonal to the Thomsen-Friedenreich Antigen (TF-Ag) which is an alpha-O-linked disaccharide antigen on the surface of ~80% of human carcinomas, including breast, lung, colon, bladder, ovarian, and prostate cancers, and is cryptic on normal cells. JAA-F11 has potential, when humanized, for cancer immunotherapy for multiple cancer types. Humanization of JAA-F11, was performed utilizing complementarity determining regions grafting on a homology framework. The objective herein is to test the specificity, affinity and biology efficacy of the humanized JAA-F11 (hJAA-F11)...
August 19, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28782867/imaging-in-gynecological-disease-11-clinical-and-ultrasound-features-of-mucinous-ovarian-tumors
#19
F Moro, G F Zannoni, D Arciuolo, T Pasciuto, S Amoroso, F Mascilini, S Mainenti, G Scambia, A C Testa
OBJECTIVE: To describe the clinical and ultrasound findings in patients with mucinous ovarian tumors. METHODS: In this retrospective study, women with a histological diagnosis of mucinous ovarian tumor who had undergone preoperative ultrasound examination were identified from the database of a single ultrasound center. The histological examination was performed by the same pathologist in all cases, and the ultrasound appearance of the tumors was described using the terms and definitions of the International Ovarian Tumor Analysis group...
August 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28758939/stonin-2-overexpression-is-correlated-with-unfavorable-prognosis-and-tumor-invasion-in-epithelial-ovarian-cancer
#20
Xiaoying Sun, Weijing Zhang, Han Li, Chunhao Niu, Yulan Ou, Libing Song, Yanna Zhang
Stonin 2 (STON2), which functions in adjusting endocytotic complexes, is probably involved in the monitoring of the internalization of dopamine D2 receptors which have an inhibitory action of dopamine on tumor progression. However, its clinical significance in tumor progression and prognosis remains unclear. We explored the association between STON2 and the clinicopathological characteristics of epithelial ovarian cancer (EOC). The STON2 levels in ovarian cancer and normal cell lines and tissues were detected by real-time PCR and Western blot analyses...
July 29, 2017: International Journal of Molecular Sciences
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