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International ovarian tumor analysis

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https://www.readbyqxmd.com/read/28401199/clinicopathology-of-epcam-and-egfr-in-human-epithelial-ovarian-carcinoma
#1
Jingying Zheng, Lijing Zhao, Yi Wang, Shuhua Zhao, Manhua Cui
The objective of this study was to explore the expression of EpCAM and EGFR in human epithelial ovarian cancer (EOC) and their correlation with clinicopathological parameters. The protein expression levels of epithelial cell adhesion molecule (EpCAM) and epidermal growth factor receptor (EGFR) were evaluated by immunohistochemistry in formalin-fixed paraffin-embedded specimens from 30 patients with epithelial ovarian carcinoma and 15 normal ovary tissues. Clinicopathological characteristics were gathered by retrospective review of the patients' files...
January 2017: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/28351334/upregulation-of-senp3-smt3ip1-promotes-epithelial-ovarian-cancer-progression-and-forecasts-poor-prognosis
#2
Jialin Cheng, Min Su, Yunfeng Jin, Qinghua Xi, Yan Deng, Jie Chen, Wei Wang, Yannan Chen, Lingling Chen, Nannan Shi, Guoxin Mao
As a crucial member of the small ubiquitin-like modifier system, SUMO-specific protease 3, was identified to be essential for cell proliferation and ribosomal RNA processing. Recent studies showed that SUMO-specific protease 3 was elevated in ovarian cancer compared to normal tissue samples. However, the connection between SUMO-specific protease 3-specific expression and clinicopathological parameters of epithelial ovarian cancer, as well as the physiologically potential role of SUMO-specific protease 3 in epithelial ovarian cancer remained unclear...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28349821/lamp3-expression-correlated-with-poor-clinical-outcome-in-human-ovarian-cancer
#3
Di Wang, Xuemin Cao, Yuquan Zhang, Yuanlin Liu, Chan Yao, Wenliang Ge, Yunzhao Xu
Lysosome-associated membrane protein 3 belongs to the lysosome-associated membrane glycoprotein family, which is associated with lymph node, metastasis, poor overall survival, and resistance to chemotherapy and radiotherapy. Epithelial ovarian cancer is one of the most deadly global female gynecologic malignant tumors. Its clinical outcome is poor and most epithelial ovarian cancer patients tend to relapse because of drug resistance. However, lysosome-associated membrane protein 3 expression in epithelial ovarian cancer and its relationship between clinicopathologic factors remain poorly understood...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28337275/microrna-215-targets-nob1-and-inhibits-growth-and-invasion-of-epithelial-ovarian-cancer
#4
Yang Lin, Yang Jin, Tianmin Xu, Shunqing Zhou, Manhua Cui
MicroRNA-215 (miR-215) has been showed to play crucial roles in tumorigenesis and tumor progression in many types of cancer. However, its biological function and underlying mechanism in epithelial ovarian cancer (EOC) remains greatly unknown. The aims of this study were to investigate biological role and underlying mechanism of miR-215 in EOC. Here, we found that miR-215 expression was significantly decreased in EOC tissues or cell lines compared with adjacent normal tissues or normal ovarian cell line. Decreased miR-215 expression was significantly associated with International Federation of Gynaecology and Obstetrics (FIGO) stage and lymph node metastasis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28315410/is-lymphadenectomy-necessary-in-mucinous-ovarian-cancer-a-single-institution-experience
#5
Ivan Salgado-Ceballos, Jazmín Ríos, Delia Pérez-Montiel, Lenny Gallardo, Salim Barquet-Muñoz, Rosa Salcedo-Hernández, Carlos Pérez-Plasencia, Luis Alonso Herrera, David Francisco Cantú de León
BACKGROUND: According to the International Federation of Gynecology and Obstetrics (FIGO) guidelines, every patient diagnosed with ovarian cancer (OC) should undergo a complete staging procedure to adequately assess tumor spread. The role of lymphadenectomy in the initial management of primary early mucinous ovarian cancer (MOC) remains unclear. OBJECTIVE: To describe the prevalence of pelvic and para-aortic node metastases in MOC. MATERIALS AND METHODS: The records of patients with MOC treated at our Institute during January 2005 to December 2011 were assessed...
March 14, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28288666/reliability-of-preoperative-evaluation-of-postmenopausal-ovarian-tumors
#6
Riikka Johanna Niemi, Sami Kristian Saarelainen, Tiina Hannele Luukkaala, Johanna Unelma Mäenpää
BACKGROUND: Preoperative evaluation of ovarian tumors is challenging. This study was undertaken to evaluate the performance of conventional two-dimensional (2D) ultrasound and CA125 in predicting malignant or benign nature of pelvic masses, and to investigate if three-dimensional power Doppler (3DPD) ultrasound provides any added value. Ninety-six postmenopausal and four perimenopausal women with supposed ovarian tumors were examined by standardized 2D and 3DPD ultrasounds preoperatively...
March 14, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28266033/first-international-consensus-report-on-adnexal-masses-management-recommendations
#7
Phyllis Glanc, Beryl Benacerraf, Tom Bourne, Douglas Brown, Beverly G Coleman, Christopher Crum, Jason Dodge, Deborah Levine, Edward Pavlik, Dirk Timmerman, Frederick R Ueland, Wendy Wolfman, Steven R Goldstein
The First International Consensus Conference on Adnexal Masses was convened to thoroughly examine the state of the science and to formulate recommendations for clinical assessment and management. The panel included representatives of societies in the fields of gynecology, gynecologic oncology, radiology, and pathology and clinicians from Europe, Canada, and the United States. In the United States, there are approximately 9.1 surgeries per malignancy compared to the European International Ovarian Tumor Analysis center trials, with only 2...
May 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28259910/reduced-expression-of-sirt2-in-serous-ovarian-carcinoma-promotes-cell-proliferation-through-disinhibition-of-cdk4-expression
#8
Yanhua Du, Jun Wu, Haiyan Zhang, Shaobo Li, Hong Sun
The silent information regulator 2 related enzyme 2 (SIRT2) has been reported to have an important role in tumorigenesis. Although two distinct effects of SIRT2 have recently been revealed, which explain opposing expression patterns in different types of cancer, the specific function of SIRT2 in ovarian cancer remains unknown. The present study investigated the expression of SIRT2 in serous ovarian carcinoma (SOC) and its pathogenic mechanism. It was observed that SIRT2 expression in SOC was significantly downregulated when compared with ovarian surface epithelium via western blot and immunohistochemistry...
April 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28253891/evaluation-of-the-correlation-of-vasculogenic-mimicry-aldh1-kiss-1-and-macc1-in-the-prediction-of-metastasis-and-prognosis-in-ovarian-carcinoma
#9
Lan Yu, Bo Zhu, Shiwu Wu, Lei Zhou, Wenqing Song, Xiaomeng Gong, Danna Wang
BACKGROUND: Recurrence and metastasis are the usual manifestations of treatment failure of epithelial ovarian carcinoma (EOC). Vasculogenic mimicry (VM; blood supply development often seen in highly aggressive cancers), aldehyde dehydrogenase 1 (ALDH1, cancer stem cell biomarker), KiSS-1 (suppressor of tumor metastasis), and metastasis associated in colon cancer-1 (MACC1) are all useful predictive factors for metastasis and prognosis in various cancers. In this study, we analyzed associations among VM, ALDH1, KiSS-1, and MACC1 in EOC, and their respective correlations with clinicopathological characteristics and survival in EOC...
March 2, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28217670/a-novel-clinicopathological-analysis-of-early-stage-ovarian-sertoli-leydig-cell-tumors-at-a-single-institution
#10
Seon Mi Nam, Jee Whan Kim, Kyung Jin Eoh, Hye Min Kim, Jung Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim, Young Tae Kim
OBJECTIVE: To evaluate the clinical and pathologic characteristics of patients who were diagnosed with ovarian Sertoli-Leydig cell tumors (SLCTs) in a single institution. METHODS: The medical records of 11 patients who were pathologically diagnosed with SLCTs beginning in 1995 in a single institute was reviewed. RESULTS: The median patient age was 31 years (range, 16 to 70 years). Patient International Federation of Gynecology and Obstetrics stages were IA, IC, and IIB in 3 (27...
January 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28216373/tweak-stimulated-macrophages-inhibit-metastasis-of-epithelial-ovarian-cancer-via-exosomal-shuttling-of-microrna
#11
Yuan Hu, Dong Li, Anyue Wu, Xingdi Qiu, Wen Di, Lei Huang, Lihua Qiu
Exosomal-miRNAs are emerging as mediators of crosstalk between tumor cells and macrophages. In this study, we observed that exosomes derived from TWEAK-stimulated macrophages (TMs) could be internalized by epithelial ovarian cancer (EOC) cells and inhibit cell metastasis. Through a miRNA microarray analysis, we identified 19 miRNAs that are differentially expressed in exosomes derived from macrophages treated with or without TWEAK. The study validated that TWEAK not only increased the levels of microRNA-7 (miR-7) in macrophages and its secreted exosomes but also resulted in an elevated level of miR-7 in recipient EOC cells, which eventually reduced the activity of the EGFR/AKT/ERK1/2 pathway...
February 16, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28202851/expression-of-inorganic-pyrophosphatase-ppa1-correlates-with-poor-prognosis-of-epithelial-ovarian-cancer
#12
Hui Li, Ning Xiao, Zongpeng Li, Qin Wang
Ovarian serous carcinoma (OSC) is the most common epithelial ovarian cancer. Inorganic pyrophosphatase (PPA1) catalyzes the hydrolysis of pyrophosphate to inorganic phosphate, thereby providing extra energy for metabolism. The significance of PPA1 in the prognosis of OSC has not been investigated. Our study aimed to explore the expression and predictive role of PPA1 in OSC progression. We screened the expression of PPA1 protein in OSC tissues from 139 patients by immunohistochemistry, and evaluated its correlation with clinicopathological characteristics...
February 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28202518/prolactin-receptor-mediated-internalization-of-imaging-agents-detects-epithelial-ovarian-cancer-with-enhanced-sensitivity-and-specificity
#13
Karthik M Sundaram, Yilin Zhang, Anirban K Mitra, Jean-Louis K Kouadio, Katja Gwin, Anthony A Kossiakoff, Brian B Roman, Ernst Lengyel, Joseph A Piccirilli
Poor prognosis of ovarian cancer, the deadliest of the gynecologic malignancies, reflects major limitations associated with detection and diagnosis. Current methods lack high sensitivity to detect small tumors and high specificity to distinguish malignant from benign tissue, both impeding diagnosis of early and metastatic cancer stages and leading to costly and invasive surgeries. Tissue microarray analysis revealed that >98% of ovarian cancers express the prolactin receptor (PRLR), forming the basis of a new molecular imaging strategy...
April 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28118296/malignancy-risk-of-sonographically-benign-appearing-purely-solid-adnexal-masses-in-asymptomatic-postmenopausal-women
#14
Juan Luis Alcazar, Maria Angela Pascual, Reyes Marquez, Silvia Ajossa, Leire Juez, Betlem Graupera, Alba Piras, Lourdes Hereter, Stefano Guerriero
OBJECTIVE: To assess the natural history of benign appearing purely solid ovarian lesions in asymptomatic postmenopausal women. METHODS: Retrospective observational cohort study comprising 99 women (mean age, 58.2 years, ranging from 50 to 77 years) diagnosed as having a purely solid ovarian lesion at transvaginal ultrasound between April 2001 and October 2015. Inclusion criteria were as follows: asymptomatic postmenopausal women with a well-defined purely solid ovarian lesion with International Ovarian Tumor Analysis color score 1 or 2, without ascites and/or signs of carcinomatosis...
January 23, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28101917/imaging-in-gynecological-disease-clinical-and-ultrasound-features-of-invasive-and-non-invasive-malignant-serous-ovarian-tumors
#15
F Moro, C Baima Poma, G F Zannoni, A Vidal Urbinati, T Pasciuto, M Ludovisi, M C Moruzzi, S Carinelli, D Franchi, G Scambia, A C Testa
OBJECTIVES: To describe clinical and ultrasound features of different subclasses of malignant serous ovarian tumors according to the WHO 2014 classification. METHODS: Patients with a histological diagnosis of borderline (BOT), non-invasive and invasive low grade serous carcinomas (LGSC) and high grade serous carcinoma (HGSC), who had undergone preoperative ultrasound examination, were retrospectively identified from two ultrasound centers. The masses were described using the terms of the International Ovarian Tumor Analysis group...
January 19, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28052682/prognostic-significance-of-mapk-topo-ii%C3%AE-and-e-cadherin-immunoexpression-in-ovarian-serous-carcinomas
#16
D Sundov, B Petric Mise, I Mrklic, B Bacic, E Vrdoljak, S Tomic
Ovarian cancer accounts for only 3% of all cancers in women but is the most lethal gynaecologic malignancy. Low-grade and high-grade ovarian serous carcinomas (OSCs) represent two different diseases with different prognosis, approaches to detection and treatment. We assessed correlation between, MAPK, topoIIα, E-cadherin immunoexpression and clinicopathological features with overall survival (OS) in OSCs. The study included 81 patients undergoing surgery between January 1995 and December 2005.Formalin fixed paraffin embedded tumour sections were reviewed and examined immunohistochemically using antibodies against MAPK, topoIIα and E-cadherin...
2017: Neoplasma
https://www.readbyqxmd.com/read/28004457/clinical-and-ultrasound-characteristics-of-surgically-removed-adnexal-lesions-with-a-largest-diameter-%C3%A2-2-5-cm-a-pictorial-essay
#17
A Di Legge, P Pollastri, R Mancari, M Ludovisi, F Mascilini, D Franchi, D Jurkovic, M E Coccia, D Timmerman, G Scambia, A Testa, L Valentin
OBJECTIVES: The aim was to describe the ultrasound characteristics, the indications for surgery and the histological diagnoses of surgically removed adnexal masses with largest diameter <2.5 cm ("very small tumors"), to estimate sensitivity and specificity with regard to malignancy of subjective assessment of ultrasound images of very small tumors, and to present a gallery of ultrasound images of surgically removed very small tumors especially those causing diagnostic difficulties...
December 22, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27888711/preoperative-monocyte-to-lymphocyte-ratio-in-peripheral-blood-predicts-stages-metastasis-and-histological-grades-in-patients-with-ovarian-cancer
#18
Jiangdong Xiang, Lina Zhou, Xing Li, Wei Bao, Taizhong Chen, Xiaowei Xi, Yinyan He, Xiaoping Wan
PURPOSE: The monocyte-to-lymphocyte ratio (MLR) has been shown to be associated with the prognosis of various solid tumors. This study sought to evaluate the important value of the MLR in ovarian cancer patients. METHODS: A total of 133 ovarian cancer patients and 43 normal controls were retrospectively reviewed. The patients' demographics were analyzed along with clinical and pathologic data. The counts of peripheral neutrophils, lymphocytes, monocytes, and platelets were collected and used to calculate the MLR, neutrophil-to-lymphocyte ratio (NLR)...
November 23, 2016: Translational Oncology
https://www.readbyqxmd.com/read/27871313/conservation-of-immune-gene-signatures-in-solid-tumors-and-prognostic-implications
#19
Julia Chifman, Ashok Pullikuth, Jeff W Chou, Davide Bedognetti, Lance D Miller
BACKGROUND: Tumor-infiltrating leukocytes can either limit cancer growth or facilitate its spread. Diagnostic strategies that comprehensively assess the functional complexity of tumor immune infiltrates could have wide-reaching clinical value. In previous work we identified distinct immune gene signatures in breast tumors that reflect the relative abundance of infiltrating immune cells and exhibited significant associations with patient outcomes. Here we hypothesized that immune gene signatures agnostic to tumor type can be identified by de novo discovery of gene clusters enriched for immunological functions and possessing internal correlation structure conserved across solid tumors from different anatomic sites...
November 22, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27797247/comparison-of-effectiveness-in-differentiating-benign-from-malignant-ovarian-masses-between-iota-simple-rules-and-subjective-sonographic-assessment
#20
Theera Tongsong, Dangcheewan Tinnangwattana, Linlada Vichak-Ururote, Paponrad Tontivuthikul, Cholaros Charoenratana, Thitikarn Lerthiranwong
BACKGROUND: To compare diagnostic performance in differentiating benign from malignant ovarian masses between IOTA (the International Ovarian Tumor Analysis) simple rules and subjective sonographic assessment. MATERIALS AND METHODS: Women scheduled for elective surgery because of ovarian masses were recruited into the study and underwent ultrasound examination within 24 hours of surgery to apply the IOTA simple rules by general gynecologists and to record video clips for subjective assessment by an experienced sonographer...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
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