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Ischemic placental disease

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https://www.readbyqxmd.com/read/27780236/conditioned-medium-from-placental-mesenchymal-stem-cells-reduces-oxidative-stress-during-the-cryopreservation-of-ex-vivo-expanded-umbilical-cord-blood-cells
#1
Darshana Kadekar, Sonal Rangole, Vaijayanti Kale, Lalita Limaye
BACKGROUND: The limited cell dose in umbilical cord blood (UCB) necessitates ex vivo expansion of UCB. Further, the effective cryopreservation of these expanded cells is important in widening their use in the clinics. During cryopreservation, cells experience oxidative stress due to the generation of reactive oxygen species (ROS). Conditioned medium from mesenchymal stem cells (MSCs-CM) has been shown to alleviate the oxidative stress during wound healing, Alzheimer's disease and ischemic disease...
2016: PloS One
https://www.readbyqxmd.com/read/27624545/circulating-free-soluble-fms-like-tyrosine-kinase-1-during-late-first-trimester-in-relation-with-placental-volume-as-a-surrogate-for-trophoblastic-production-a-physiology-study-in-low-risk-cohort
#2
Sudtawin Manthati, Busadee Pratumvinit, Ratchaneekorn Hanyongyuth, Suthipol Udompunthurak, Amprapha Phaophan, Tuangsit Wataganara
BACKGROUND: Data on first-trimester circulating soluble fms-like tyrosine kinase-1 (sFlt-1) and ischemic placental disease is limited and conflicting. This study aimed to study its physiology in relation to trophoblastic mass as the source of production. METHODS: Low-risk (representing normal placentation) women from 11 0/7 to 13 6/7 weeks' gestation were prospectively enrolled. Selective measurement of serum free sFlt-1 using a new automated assay from 100 eligible subjects was analyzed with gestational age, maternal weight, fetal crown-rump length (CRL), and mean uterine artery Doppler pulsatility index (PI)...
September 14, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27608972/placental-growth-factor-what-hematologists-need-to-know
#3
Laura F Newell, Shernan G Holtan
Although first identified in placenta, the angiogenic factor known as placental growth factor (PlGF) can be widely expressed in ischemic or damaged tissues. Recent studies have indicated that PlGF is a relevant factor in the pathobiology of blood diseases including hemoglobinopathies and hematologic malignancies. Therapies for such blood diseases may one day be based upon these and ongoing investigations into the role of PlGF in sickle cell disease, acute and chronic leukemias, and complications related to hematopoietic cell transplantation...
August 27, 2016: Blood Reviews
https://www.readbyqxmd.com/read/27160365/complement-inhibition-by-hydroxychloroquine-prevents-placental-and-fetal-brain-abnormalities-in-antiphospholipid-syndrome
#4
Maria Laura Bertolaccini, Gregorio Contento, Ross Lennen, Giovanni Sanna, Philip J Blower, Michelle T Ma, Kavitha Sunassee, Guillermina Girardi
Placental ischemic disease and adverse pregnancy outcomes are frequently observed in patients with antiphospholipid syndrome (APS). Despite the administration of conventional antithrombotic treatment a significant number of women continue to experience adverse pregnancy outcomes, with uncertain prevention and management. Efforts to develop effective pharmacological strategies for refractory obstetric APS cases will be of significant clinical benefit for both mothers and fetuses. Although the antimalarial drug, hydroxychloroquine (HCQ) is increasingly used to treat pregnant women with APS, little is known about its efficacy and mechanism of action of HCQ...
May 6, 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27091182/neovascularization-potential-of-blood-outgrowth-endothelial-cells-from-patients-with-stable-ischemic-heart-failure-is-preserved
#5
Dieter Dauwe, Beatriz Pelacho, Arief Wibowo, Ann-Sophie Walravens, Kristoff Verdonck, Hilde Gillijns, Ellen Caluwe, Peter Pokreisz, Nick van Gastel, Geert Carmeliet, Maarten Depypere, Frederik Maes, Nina Vanden Driessche, Walter Droogne, Johan Van Cleemput, Johan Vanhaecke, Felipe Prosper, Catherine Verfaillie, Aernout Luttun, Stefan Janssens
BACKGROUND: Blood outgrowth endothelial cells (BOECs) mediate therapeutic neovascularization in experimental models, but outgrowth characteristics and functionality of BOECs from patients with ischemic cardiomyopathy (ICMP) are unknown. We compared outgrowth efficiency and in vitro and in vivo functionality of BOECs derived from ICMP with BOECs from age-matched (ACON) and healthy young (CON) controls. METHODS AND RESULTS: We isolated 3.6±0.6 BOEC colonies/100×10(6) mononuclear cells (MNCs) from 60-mL blood samples of ICMP patients (n=45; age: 66±1 years; LVEF: 31±2%) versus 3...
April 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27045698/novel-3d-light-microscopic-analysis-of-iugr-placentas-points-to-a-morphological-correlate-of-compensated-ischemic-placental-disease-in-humans
#6
Eva Haeussner, Christoph Schmitz, Hans-Georg Frank, Franz Edler von Koch
The villous tree of the human placenta is a complex three-dimensional (3D) structure with branches and nodes at the feto-maternal border in the key area of gas and nutrient exchange. Recently we introduced a novel, computer-assisted 3D light microscopic method that enables 3D topological analysis of branching patterns of the human placental villous tree. In the present study we applied this novel method to the 3D architecture of peripheral villous trees of placentas from patients with intrauterine growth retardation (IUGR placentas), a severe obstetric syndrome...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26925462/controlled-angiogenesis-in-peptide-nanofiber-composite-hydrogels
#7
Navindee C Wickremasinghe, Vivek A Kumar, Siyu Shi, Jeffrey D Hartgerink
Multidomain peptide (MDP) nanofibers create scaffolds that can present bioactive cues to promote biological responses. Orthogonal self-assembly of MDPs and growth-factor-loaded liposomes generate supramolecular composite hydrogels. These composites can act as delivery vehicles with time-controlled release. Here we examine the controlled release of placental growth factor-1 (PlGF-1) for its ability to induce angiogenic responses. PlGF-1 was loaded either in MDP matrices or within liposomes bound inside MDP matrices...
September 14, 2015: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/26909042/placental-nutrient-transport-and-intrauterine-growth-restriction
#8
REVIEW
Francesca Gaccioli, Susanne Lager
Intrauterine growth restriction refers to the inability of the fetus to reach its genetically determined potential size. Fetal growth restriction affects approximately 5-15% of all pregnancies in the United States and Europe. In developing countries the occurrence varies widely between 10 and 55%, impacting about 30 million newborns per year. Besides having high perinatal mortality rates these infants are at greater risk for severe adverse outcomes, such as hypoxic ischemic encephalopathy and cerebral palsy...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/26569331/immune-mechanisms-linking-obesity-and-preeclampsia
#9
REVIEW
Frank T Spradley, Ana C Palei, Joey P Granger
Preeclampsia (PE) is characterized by hypertension occurring after the twentieth week of pregnancy. It is a significant contributor to maternal and perinatal morbidity and mortality in developing countries and its pervasiveness is increasing within developed countries including the USA. However, the mechanisms mediating the pathogenesis of this maternal disorder and its rising prevalence are far from clear. A major theory with strong experimental evidence is that placental ischemia, resulting from inappropriate remodeling and widening of the maternal spiral arteries, stimulates the release of soluble factors from the ischemic placenta causing maternal endothelial dysfunction and hypertension...
November 12, 2015: Biomolecules
https://www.readbyqxmd.com/read/26444581/ischemic-placental-syndrome-prediction-and-new-disease-monitoring
#10
Sebastian Kwiatkowski, Ewa Kwiatkowska, Rafał Rzepka, Andrzej Torbe, Barbara Dolegowska
The last decade has seen an improved understanding of the cause of the development of pathologies such as gestational hypertension, preeclampsia, intrauterine growth restriction, intrauterine fetal death or placental abruption. Nowadays, we know that most conditions within this group share the same pathogenesis, the cause of which is placental ischemia. The following review is an attempt to propose a new method for prediction, diagnosis and--above all--appropriate monitoring of pregnant women and fetuses developing the ischemic placental syndrome with the use of tests that are new but yet widely available in clinical diagnosis...
2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26291780/the-association-between-umbilical-cord-abnormalities-and-the-development-of-non-reassuring-fetal-heart-rate-leading-to-emergent-cesarean-deliveries
#11
COMPARATIVE STUDY
E Weiner, N Fainstein, L Schreiber, R Sagiv, J Bar, M Kovo
OBJECTIVE: To study the contribution of umbilical cord (UC) abnormalities in emergent cesarean deliveries (ECDs) for non-reassuring fetal heart rate (NRFHR) and to explore their association with placental histopathology and neonatal outcome. STUDY DESIGN: Data from 530 ECDs for NRFHR were reviewed for the occurrence of UC abnormalities. Those included the presence of UC entanglements, the number and location of loops, true knots and short cord (<50 cm). Multiple UC entanglements were defined as ⩾ 2 UC loops...
November 2015: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/26149518/placental-elasticity-evaluation-using-virtual-touch-tissue-quantification-during-pregnancy
#12
Takako Ohmaru, Yasuyuki Fujita, Maiko Sugitani, Mototsugu Shimokawa, Kotaro Fukushima, Kiyoko Kato
INTRODUCTION: Virtual touch tissue quantification (VTTQ) has been developed to evaluate tissue elasticity. Our previous study using delivered placentas showed increased elasticity in fetal growth restriction (FGR). Therefore, we investigated changes in placental elasticity during pregnancy, including complicated pregnancies. METHODS: Based on complications, 199 women were divided into 5 groups (normal, FGR, pregnancy induced hypertension (PIH), diabetes mellitus and collagen disease), and shear wave velocity (SWV) of the placenta, measured using VTTQ, was compared...
August 2015: Placenta
https://www.readbyqxmd.com/read/26081109/incidence-of-obstetrical-thrombotic-thrombocytopenic-purpura-in-a-retrospective-study-within-thrombocytopenic-pregnant-women-a-difficult-diagnosis-and-a-treatable-disease
#13
Yahsou Delmas, Sébastien Helou, Pierre Chabanier, Anne Ryman, Fanny Pelluard, Dominique Carles, Pierre Boisseau, Agnès Veyradier, Jacques Horovitz, Paul Coppo, Christian Combe
BACKGROUND: Thrombotic thrombocytopenic Purpura (TTP) defined as ADAMTS-13 (A Disintegrin And Metalloprotease with ThromboSpondin type 1 domain 13) activity <10 % is a rare aetiology of thrombocytopenia during pregnancy, although the precise incidence is unknown. During pregnancy, the diagnosis of TTP is crucial as it has high feto-maternal morbidity-mortality and requires urgent plasma exchange. The purpose of this study was to assess the incidence of TTP retrospectively and to describe case presentations and follow-up...
June 17, 2015: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/26054585/angiogenic-properties-of-human-placenta-derived-adherent-cells-and-efficacy-in-hindlimb-ischemia
#14
Aleksandar Francki, Kristen Labazzo, Shuyang He, Ellen Z Baum, Stewart E Abbot, Uri Herzberg, Wolfgang Hofgartner, Robert Hariri
OBJECTIVE: Human placenta-derived adherent cells (PDACs) are a culture-expanded, undifferentiated mesenchymal-like population from full-term placental tissue and were previously shown to possess anti-inflammatory and immunomodulatory properties. PDACs (formulated as PDA-002) are in clinical trials for peripheral arterial disease with diabetic foot ulcer. In the current study, we examined their angiogenic and tissue reparative properties. METHODS: The effects of PDACs on survival and tube formation of human umbilical vein endothelial cells (HUVECs) were tested using conditioned media and noncontact coculture...
September 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/25826430/coxsackie-virus-a16-infection-of-placenta-with-massive-perivillous-fibrin-deposition-leading-to-intrauterine-fetal-demise-at-36-weeks-gestation
#15
Weiming Yu, Raymond Tellier, James R Wright
Massive perivillous fibrin deposition (MPFD) is an uncommon placental disorder, associated with significant fetal morbidity, mortality, and recurrence; its etiology is unknown. We describe a 31-year-old mother, diagnosed with Coxsackievirus infection and hand-foot-and-mouth disease at 35 weeks gestation. Ultrasound at 35 weeks revealed a normal fetus and placenta. One week later, the mother experienced decreased fetal movement and ultrasound demonstrated intrauterine demise. The autopsy showed mild, acute pericarditis and hypoxic-ischemic encephalopathy...
July 2015: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/25787479/-130-pos-placental-abruption-and-long-term-maternal-cardiovascular-disease-mortality-a-population-based-registry-study-in-norway-and-sweden
#16
Lisa A DeRoo, Rolv Skjaerven, Allen J Wilcox, Kari Klungsoyr, Anna-Karin Wikstrom, Nils-Halvdan Morken, Sven Cnattingius
OBJECTIVES: Women with preeclamptic pregnancies have increased risk of long-term cardiovascular mortality. We explored this mortality risk among women with placental abruption, another placental pathology. METHODS: We used linked Medical Birth Registry and Death Registry data to study cardiovascular disease mortality among women with a first singleton birth between 1967 and 2002 in Norway and 1973 and 2003 in Sweden. Cox regression analysis was used to estimate associations between placental abruption and cardiovascular disease death adjusting for maternal age, education, year of the pregnancy and country...
January 2015: Pregnancy Hypertension
https://www.readbyqxmd.com/read/25707334/prospective-study-of-time-to-pregnancy-and-adverse-birth-outcomes
#17
Lauren A Wise, Ellen M Mikkelsen, Henrik Toft Sørensen, Kenneth J Rothman, Kristen A Hahn, Anders H Riis, Elizabeth E Hatch
OBJECTIVE: To investigate the association between time to pregnancy (TTP) and adverse birth outcomes. DESIGN: Prospective cohort study. SETTING: Not applicable. PATIENT(S): A total of 3,521 singletons born to women aged 18-40 years at cohort entry. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Selected birth outcomes, including preterm birth (PTB, <37 weeks' gestation), low birth weight (<2,500 g), small for gestational age, large for gestational age, and placental disorders, ascertained from the Danish Medical Birth Registry and Danish National Registry of Patients...
April 2015: Fertility and Sterility
https://www.readbyqxmd.com/read/25701267/a-retrospective-survey-studying-the-impact-of-fabry-disease-on-pregnancy
#18
Alexandrea Holmes, Dawn Laney
Fabry disease (FD) is a lysosomal storage disorder resulting from a deficiency of lysosomal enzyme α-galactosidase A (α-gal A). Reduced or missing α-gal A enzyme results in the storage of globotriaosylceramide (GL3) and related glycosphingolipids in the cellular lysosomes throughout the body. The majority of GL3 buildup occurs in the body's vasculature resulting in narrowed blood vessels and an increased risk for strokes, transient ischemic attacks, and deep vein thrombosis. Theoretical concerns have been raised about increased pregnancy complications in women affected by FD as glycosphingolipid storage has been found in both maternal- and fetal-derived placental tissues...
2015: JIMD Reports
https://www.readbyqxmd.com/read/25553352/intraoperative-findings-placental-assessment-and-neonatal-outcome-in-emergent-cesarean-deliveries-for-non-reassuring-fetal-heart-rate
#19
Eran Weiner, Jacob Bar, Nataly Fainstein, Letizia Schreiber, Avi Ben-Haroush, Michal Kovo
OBJECTIVE: To correlate between intraoperative findings, placental histopathology and neonatal outcome in emergent cesarean deliveries (ECD) for non-reassuring fetal heart rate (NRFHR). STUDY DESIGN: Data on ECD for NRFHR were reviewed for labor, documented intraoperative findings, neonatal outcome parameters and placental histopathology reports. Results were compared between those with and without intraoperative findings. Placental lesions were classified to those related to maternal underperfusion or fetal thrombo-occlusive disease, and those related to maternal (MIR) and fetal (FIR) inflammatory responses...
February 2015: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/25270247/prenatal-drinking-water-exposure-to-tetrachloroethylene-and-ischemic-placental-disease-a-retrospective-cohort-study
#20
Jenny L Carwile, Shruthi Mahalingaiah, Michael R Winter, Ann Aschengrau
BACKGROUND: Prenatal drinking water exposure to tetrachloroethylene (PCE) has been previously related to intrauterine growth restriction and stillbirth. Pathophysiologic and epidemiologic evidence linking these outcomes to certain other pregnancy complications, including placental abruption, preeclampsia, and small-for-gestational-age (SGA) (i.e., ischemic placental diseases), suggests that PCE exposure may also be associated with these events. We examined whether prenatal exposure to PCE-contaminated drinking water was associated with overall or individual ischemic placental diseases...
2014: Environmental Health: a Global Access Science Source
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