keyword
MENU ▼
Read by QxMD icon Read
search

Ischemic placental disease

keyword
https://www.readbyqxmd.com/read/28974256/exosomes-of-human-placenta-derived-mesenchymal-stem-cells-stimulate-angiogenesis
#1
Motohiro Komaki, Yuri Numata, Chikako Morioka, Izumi Honda, Masayuki Tooi, Naoki Yokoyama, Hirohito Ayame, Kengo Iwasaki, Atsuko Taki, Noriko Oshima, Ikuo Morita
BACKGROUND: The therapeutic potential of mesenchymal stem cells (MSCs) may be attributed partly to humoral factors such as growth factors, cytokines, and chemokines. Human term placental tissue-derived MSCs (PlaMSCs), or conditioned medium left over from cultures of these cells, have been reported to enhance angiogenesis. Recently, the exosome, which can transport a diverse suite of macromolecules, has gained attention as a novel intercellular communication tool. However, the potential role of the exosome in PlaMSC therapeutic action is not well understood...
October 3, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28672786/residential-proximity-to-roadways-and-ischemic-placental-disease-in-a-cape-cod-family-health-study
#2
Amelia K Wesselink, Jenny L Carwile, María Patricia Fabian, Michael R Winter, Lindsey J Butler, Shruthi Mahalingaiah, Ann Aschengrau
Exposure to air pollution may adversely impact placental function through a variety of mechanisms; however, epidemiologic studies have found mixed results. We examined the association between traffic exposure and placental-related obstetric conditions in a retrospective cohort study on Cape Cod, MA, USA. We assessed exposure to traffic using proximity metrics (distance of residence to major roadways and length of major roadways within a buffer around the residence). The outcomes included self-reported ischemic placental disease (the presence of at least one of the following conditions: preeclampsia, placental abruption, small-for-gestational-age), stillbirth, and vaginal bleeding...
June 24, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28651900/potential-clinical-applications-of-placental-stem-cells-for-use-in-fetal-therapy-of-birth-defects
#3
Melissa Vanover, Aijun Wang, Diana Farmer
Placental stem cells are of growing interest for a variety of clinical applications due to their multipotency and ready availability from otherwise frequently discarded biomaterial. Stem cells derived from the placenta have been investigated in a number of disease processes, including wound healing, ischemic heart disease, autoimmune disorders, and chronic lung or liver injury. Fetal intervention for structural congenital defects, such as spina bifida, has rapidly progressed as a field due to advances in maternal-fetal medicine and improving surgical techniques...
May 18, 2017: Placenta
https://www.readbyqxmd.com/read/28397162/sustained-placental-growth-factor-2-treatment-does-not-aggravate-advanced-atherosclerosis-in-ischemic-cardiomyopathy
#4
Ming Wu, Peter Pokreisz, Melissa Swinnen, Ellen Caluwe, Hilde Gillijns, Nina Vanden Driessche, Andrea Casazza, Erik Verbeken, Desire Collen, Stefan Janssens
Angiogenic growth factor therapy for ischemic cardiovascular disease carries a risk of stimulating atherosclerotic plaque growth. We evaluated risk benefit ratio of sustained administration of recombinant human placental growth factor (rhPlGF)-2 in mice with advanced atherosclerosis and chronic ischemic cardiomyopathy. We maintained apolipoprotein E-deficient mice on a high cholesterol diet and induced myocardial infarction by transient ligation at 4 weeks. At 8 weeks, we assessed left ventricular (LV) function and randomized mice to receive rhPlGF-2 or vehicle (VEH) subcutaneously for 28 days...
April 10, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28165141/a-prospective-study-on-first-trimester-prediction-of-ischemic-placental-diseases
#5
Gulnar Nuriyeva, Semir Kose, Gamze Tuna, Melis Kant, Merve Akis, Sabahattin Altunyurt, Gül Huray Islekel, Omer Erbil Dogan
OBJECTIVE: The objective of the study is to assess the predictive power of mean uterine artery pulsatility index (UtA PI), maternal serum placental growth factor (PlGF) and placenta associated plasma protein A levels for the development of ischemic placental diseases (IPD) in a cohort of unselected singleton pregnancies during the first trimester combined test period. MATERIALS AND METHODS: A sample of 880 pregnancies was registered between September 2014 and January 2016...
April 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28102332/dynamic-modeling-of-uteroplacental-blood-flow-in-iugr-indicates-vortices-and-elevated-pressure-in-the-intervillous-space-a-pilot-study
#6
Christian J Roth, Eva Haeussner, Tanja Ruebelmann, Franz V Koch, Christoph Schmitz, Hans-Georg Frank, Wolfgang A Wall
Ischemic placental disease is a concept that links intrauterine growth retardation (IUGR) and preeclampsia (PE) back to insufficient remodeling of uterine spiral arteries. The rheological consequences of insufficient remodeling of uterine spiral arteries were hypothesized to mediate the considerably later manifestation of obstetric disease. However, the micro-rheology in the intervillous space (IVS) cannot be examined clinically and rheological animal models of the human IVS do not exist. Thus, an in silico approach was implemented to provide in vivo inaccessible data...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27978593/fetal-neurosonogaphy-ultrasound-and-magnetic-resonance-imaging-in-competition
#7
COMMENT
S Tercanli, F Prüfer
Both in routine diagnostics and detailed, highly specialized workups, major advances have been observed in many areas of ultrasound due to an increase in expertise and improved technology in recent years. This is particularly true in the case of fetal neurosonography 1 2 3 4. Malformations of the CNS together with fetal heart defects are among the most common congenital anomalies. From the embryonic phase to the late third trimester, the CNS undergoes extensive development and maturation processes. The diagnosis of CNS anomalies is therefore primarily dependent on the time at which the examination is performed and the experience of the examiner...
December 2016: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/27780236/conditioned-medium-from-placental-mesenchymal-stem-cells-reduces-oxidative-stress-during-the-cryopreservation-of-ex-vivo-expanded-umbilical-cord-blood-cells
#8
Darshana Kadekar, Sonal Rangole, Vaijayanti Kale, Lalita Limaye
BACKGROUND: The limited cell dose in umbilical cord blood (UCB) necessitates ex vivo expansion of UCB. Further, the effective cryopreservation of these expanded cells is important in widening their use in the clinics. During cryopreservation, cells experience oxidative stress due to the generation of reactive oxygen species (ROS). Conditioned medium from mesenchymal stem cells (MSCs-CM) has been shown to alleviate the oxidative stress during wound healing, Alzheimer's disease and ischemic disease...
2016: PloS One
https://www.readbyqxmd.com/read/27624545/circulating-free-soluble-fms-like-tyrosine-kinase-1-during-late-first-trimester-in-relation-with-placental-volume-as-a-surrogate-for-trophoblastic-production-a-physiology-study-in-low-risk-cohort
#9
Sudtawin Manthati, Busadee Pratumvinit, Ratchaneekorn Hanyongyuth, Suthipol Udompunthurak, Amprapha Phaophan, Tuangsit Wataganara
BACKGROUND: Data on first-trimester circulating soluble fms-like tyrosine kinase-1 (sFlt-1) and ischemic placental disease is limited and conflicting. This study aimed to study its physiology in relation to trophoblastic mass as the source of production. METHODS: Low-risk (representing normal placentation) women from 11 0/7 to 13 6/7 weeks' gestation were prospectively enrolled. Selective measurement of serum free sFlt-1 using a new automated assay from 100 eligible subjects was analyzed with gestational age, maternal weight, fetal crown-rump length (CRL), and mean uterine artery Doppler pulsatility index (PI)...
February 5, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27608972/placental-growth-factor-what-hematologists-need-to-know
#10
REVIEW
Laura F Newell, Shernan G Holtan
Although first identified in placenta, the angiogenic factor known as placental growth factor (PlGF) can be widely expressed in ischemic or damaged tissues. Recent studies have indicated that PlGF is a relevant factor in the pathobiology of blood diseases including hemoglobinopathies and hematologic malignancies. Therapies for such blood diseases may one day be based upon these and ongoing investigations into the role of PlGF in sickle cell disease, acute and chronic leukemias, and complications related to hematopoietic cell transplantation...
January 2017: Blood Reviews
https://www.readbyqxmd.com/read/27160365/complement-inhibition-by-hydroxychloroquine-prevents-placental-and-fetal-brain-abnormalities-in-antiphospholipid-syndrome
#11
Maria Laura Bertolaccini, Gregorio Contento, Ross Lennen, Giovanni Sanna, Philip J Blower, Michelle T Ma, Kavitha Sunassee, Guillermina Girardi
Placental ischemic disease and adverse pregnancy outcomes are frequently observed in patients with antiphospholipid syndrome (APS). Despite the administration of conventional antithrombotic treatment a significant number of women continue to experience adverse pregnancy outcomes, with uncertain prevention and management. Efforts to develop effective pharmacological strategies for refractory obstetric APS cases will be of significant clinical benefit for both mothers and fetuses. Although the antimalarial drug, hydroxychloroquine (HCQ) is increasingly used to treat pregnant women with APS, little is known about its efficacy and mechanism of action of HCQ...
December 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27091182/neovascularization-potential-of-blood-outgrowth-endothelial-cells-from-patients-with-stable-ischemic-heart-failure-is-preserved
#12
Dieter Dauwe, Beatriz Pelacho, Arief Wibowo, Ann-Sophie Walravens, Kristoff Verdonck, Hilde Gillijns, Ellen Caluwe, Peter Pokreisz, Nick van Gastel, Geert Carmeliet, Maarten Depypere, Frederik Maes, Nina Vanden Driessche, Walter Droogne, Johan Van Cleemput, Johan Vanhaecke, Felipe Prosper, Catherine Verfaillie, Aernout Luttun, Stefan Janssens
BACKGROUND: Blood outgrowth endothelial cells (BOECs) mediate therapeutic neovascularization in experimental models, but outgrowth characteristics and functionality of BOECs from patients with ischemic cardiomyopathy (ICMP) are unknown. We compared outgrowth efficiency and in vitro and in vivo functionality of BOECs derived from ICMP with BOECs from age-matched (ACON) and healthy young (CON) controls. METHODS AND RESULTS: We isolated 3.6±0.6 BOEC colonies/100×10(6) mononuclear cells (MNCs) from 60-mL blood samples of ICMP patients (n=45; age: 66±1 years; LVEF: 31±2%) versus 3...
April 18, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27045698/novel-3d-light-microscopic-analysis-of-iugr-placentas-points-to-a-morphological-correlate-of-compensated-ischemic-placental-disease-in-humans
#13
Eva Haeussner, Christoph Schmitz, Hans-Georg Frank, Franz Edler von Koch
The villous tree of the human placenta is a complex three-dimensional (3D) structure with branches and nodes at the feto-maternal border in the key area of gas and nutrient exchange. Recently we introduced a novel, computer-assisted 3D light microscopic method that enables 3D topological analysis of branching patterns of the human placental villous tree. In the present study we applied this novel method to the 3D architecture of peripheral villous trees of placentas from patients with intrauterine growth retardation (IUGR placentas), a severe obstetric syndrome...
April 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26925462/controlled-angiogenesis-in-peptide-nanofiber-composite-hydrogels
#14
Navindee C Wickremasinghe, Vivek A Kumar, Siyu Shi, Jeffrey D Hartgerink
Multidomain peptide (MDP) nanofibers create scaffolds that can present bioactive cues to promote biological responses. Orthogonal self-assembly of MDPs and growth-factor-loaded liposomes generate supramolecular composite hydrogels. These composites can act as delivery vehicles with time-controlled release. Here we examine the controlled release of placental growth factor-1 (PlGF-1) for its ability to induce angiogenic responses. PlGF-1 was loaded either in MDP matrices or within liposomes bound inside MDP matrices...
September 14, 2015: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/26909042/placental-nutrient-transport-and-intrauterine-growth-restriction
#15
REVIEW
Francesca Gaccioli, Susanne Lager
Intrauterine growth restriction refers to the inability of the fetus to reach its genetically determined potential size. Fetal growth restriction affects approximately 5-15% of all pregnancies in the United States and Europe. In developing countries the occurrence varies widely between 10 and 55%, impacting about 30 million newborns per year. Besides having high perinatal mortality rates these infants are at greater risk for severe adverse outcomes, such as hypoxic ischemic encephalopathy and cerebral palsy...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/26569331/immune-mechanisms-linking-obesity-and-preeclampsia
#16
REVIEW
Frank T Spradley, Ana C Palei, Joey P Granger
Preeclampsia (PE) is characterized by hypertension occurring after the twentieth week of pregnancy. It is a significant contributor to maternal and perinatal morbidity and mortality in developing countries and its pervasiveness is increasing within developed countries including the USA. However, the mechanisms mediating the pathogenesis of this maternal disorder and its rising prevalence are far from clear. A major theory with strong experimental evidence is that placental ischemia, resulting from inappropriate remodeling and widening of the maternal spiral arteries, stimulates the release of soluble factors from the ischemic placenta causing maternal endothelial dysfunction and hypertension...
November 12, 2015: Biomolecules
https://www.readbyqxmd.com/read/26444581/ischemic-placental-syndrome-prediction-and-new-disease-monitoring
#17
REVIEW
Sebastian Kwiatkowski, Ewa Kwiatkowska, Rafał Rzepka, Andrzej Torbe, Barbara Dolegowska
The last decade has seen an improved understanding of the cause of the development of pathologies such as gestational hypertension, preeclampsia, intrauterine growth restriction, intrauterine fetal death or placental abruption. Nowadays, we know that most conditions within this group share the same pathogenesis, the cause of which is placental ischemia. The following review is an attempt to propose a new method for prediction, diagnosis and--above all--appropriate monitoring of pregnant women and fetuses developing the ischemic placental syndrome with the use of tests that are new but yet widely available in clinical diagnosis...
2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26291780/the-association-between-umbilical-cord-abnormalities-and-the-development-of-non-reassuring-fetal-heart-rate-leading-to-emergent-cesarean-deliveries
#18
COMPARATIVE STUDY
E Weiner, N Fainstein, L Schreiber, R Sagiv, J Bar, M Kovo
OBJECTIVE: To study the contribution of umbilical cord (UC) abnormalities in emergent cesarean deliveries (ECDs) for non-reassuring fetal heart rate (NRFHR) and to explore their association with placental histopathology and neonatal outcome. STUDY DESIGN: Data from 530 ECDs for NRFHR were reviewed for the occurrence of UC abnormalities. Those included the presence of UC entanglements, the number and location of loops, true knots and short cord (<50 cm). Multiple UC entanglements were defined as ⩾ 2 UC loops...
November 2015: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/26149518/placental-elasticity-evaluation-using-virtual-touch-tissue-quantification-during-pregnancy
#19
Takako Ohmaru, Yasuyuki Fujita, Maiko Sugitani, Mototsugu Shimokawa, Kotaro Fukushima, Kiyoko Kato
INTRODUCTION: Virtual touch tissue quantification (VTTQ) has been developed to evaluate tissue elasticity. Our previous study using delivered placentas showed increased elasticity in fetal growth restriction (FGR). Therefore, we investigated changes in placental elasticity during pregnancy, including complicated pregnancies. METHODS: Based on complications, 199 women were divided into 5 groups (normal, FGR, pregnancy induced hypertension (PIH), diabetes mellitus and collagen disease), and shear wave velocity (SWV) of the placenta, measured using VTTQ, was compared...
August 2015: Placenta
https://www.readbyqxmd.com/read/26081109/incidence-of-obstetrical-thrombotic-thrombocytopenic-purpura-in-a-retrospective-study-within-thrombocytopenic-pregnant-women-a-difficult-diagnosis-and-a-treatable-disease
#20
Yahsou Delmas, Sébastien Helou, Pierre Chabanier, Anne Ryman, Fanny Pelluard, Dominique Carles, Pierre Boisseau, Agnès Veyradier, Jacques Horovitz, Paul Coppo, Christian Combe
BACKGROUND: Thrombotic thrombocytopenic Purpura (TTP) defined as ADAMTS-13 (A Disintegrin And Metalloprotease with ThromboSpondin type 1 domain 13) activity <10 % is a rare aetiology of thrombocytopenia during pregnancy, although the precise incidence is unknown. During pregnancy, the diagnosis of TTP is crucial as it has high feto-maternal morbidity-mortality and requires urgent plasma exchange. The purpose of this study was to assess the incidence of TTP retrospectively and to describe case presentations and follow-up...
June 17, 2015: BMC Pregnancy and Childbirth
keyword
keyword
45267
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"