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Paraneoplastic pemphigus

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https://www.readbyqxmd.com/read/29749393/correction-paraneoplastic-autoimmune-multiorgan-syndrome-and-paraneoplastic-pemphigus-describe-the-same-spectrum-of-disease-pathology
#1
Aimee S Payne, Michael Kasperkiewicz, Christoph T Ellebrecht, Hayato Takahashi, Jun Yamagami, Detlef Zillikens, Masayuki Amagai
This corrects the article DOI: 10.1038/nrdp.2018.13.
May 11, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29630151/paraneoplastic-pemphigus-without-antibodies-to-desmoglein-1-and-3
#2
Kelsey Flood, Christopher Stroud, Zelmira Lazarov, Nadarajah Vigneswara, Sylvia Hsu
Paraneoplastic pemphigus is a severe autoimmune blistering disease presenting in the setting of underlying malignancy. Paraneoplastic pemphigus is associated with diffuse painful stomatitis throughout the oral cavity with extension to the lips. The cutaneous findings are varied and have been described as lichenoid, pemphigoid, and targetoid lesions. Herein, we report a patient with paraneoplastic pemphigus whose routine testing led to a diagnosis of pemphigus vulgaris. However, further testing was pursued revealing an antibody profile consistent with paraneoplastic pemphigus...
February 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29599682/paraneoplastic-pemphigus-with-anti-desmocollin-3-autoantibodies-and-chronic-lymphocytic-leukemia
#3
Alicja Adaszewska, Norito Ishii, Jadwiga Dwilewicz-Trojaczek, Katarzyna Woźniak, Takashi Hashimoto, Cezary Kowalewski
No abstract text is available yet for this article.
February 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29566927/blistering-diseases-in-the-mature-patient
#4
Ines Lakoš Jukić, Sandra Jerković Gulin, Branka Marinović
Autoimmune blistering diseases (AIBD) are a group of chronic diseases affecting the skin and mucous membranes, with different presentation, clinical course, histologic and immunopathologic findings, and different therapeutic approach. Blisters develop as a result of autoantibodies directed against distinct adhesion structures within desmosomes or within the basement membrane zone. The most common AIBD that develops in the elderly is bullous pemphigoid (previously also named "pemphigoid senilis"), but mature patients can also present with other AIBD as mucous membrane pemphigoid, epidermolysis bullosa acquisita, paraneoplastic pemphigus, pemphigus vulgaris, pemphigus foliaceus, linear IgA dermatosis, and dermatitis herpetiformis...
March 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29562442/-paraneoplastic-pemphigus-associated-with-chronic-lymphocytic-leukemia-a-case-report
#5
K L Wang, Y P Xie, Y Xu, P F Shi, S X Qian
No abstract text is available yet for this article.
February 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29561527/paraneoplastic-pemphigus-associated-with-castleman-disease-detected-by-18f-fdg-pet-ct
#6
Zhanli Fu, Meng Liu, Xueqi Chen, Xing Yang, Qian Li
A 36-year-old woman suffering from oral ulcerations, skin rash, and dyspnea was suspected of having paraneoplastic pemphigus. An F-FDG PET/CT was performed to detect the underlying neoplasms and revealed an F-FDG-avid mass in the lower right retroperitoneum. The mucocutaneous lesions and dyspnea were relieved after the tumor excision, and the pathology indicated Castleman disease.
March 20, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29536971/clinical-immunological-profile-and-follow-up-of-patients-with-pemphigus-a-study-from-india
#7
Sivaranjini Ramassamy, Poonam Agrawal, Dharshini Sathishkumar, Lydia Mathew, John Victor Peter, Thenmozhi Mani, Renu George
BACKGROUND: Pemphigus has a protracted course and multiple factors influence its prognosis. The objective of this study was to describe the epidemiology and clinical profile of pemphigus patients and to study its influence on treatment end points. METHODS: This was a retrospective chart review done in an Indian tertiary care hospital from December 1991 to December 2013. Patients with less than 3 months' follow up and those who had paraneoplastic pemphigus were excluded...
March 12, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29526963/paraneoplastic-pemphigus-associated-with-b-cell-chronic-lymphocytic-leukemia-treated-with-ibrutinib-and-rituximab
#8
Yuta Ito, Shinichi Makita, Akiko Miyagi Maeshima, Shunsuke Hatta, Tomotaka Suzuki, Sayako Yuda, Suguru Fukuhara, Wataru Munakata, Tatsuya Suzuki, Dai Maruyama, Koji Izutsu
Paraneoplastic pemphigus (PNP) is a severe autoimmune blistering disease associated with an underlying malignancy, and its prognosis is poor. We herein report the first patient with B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL)-associated PNP successfully treated with the Bruton's tyrosine kinase inhibitor ibrutinib and rituximab. Although his PNP lesions did not improve with ibrutinib monotherapy, the combination of ibrutinib and rituximab was effective against B-CLL/SLL-associated PNP...
March 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29512980/oral-pemphigus
#9
Luca Giannetti, Luigi Generali, Carlo Bertoldi
The involvement of the oral mucosa in patients affected by pemphigus vulgaris (PV), paraneoplastic, IgA pemphigus, and in some cases iatrogenic pemphigus is common and often a prelude to skin lesions. Intraepidermal bullae are caused by acantholysis, induced by IgG autoantibodies directed against the desmosomes and the domain of numerous keratinocytes self-antigens desmogleins (namely cadherins), thus supporting the autoimmune nature of the disease. Apoptosis may contribute to the acantholysis. Oral mucosal lesions are more commonly refractory to treatment compared to skin lesions and have been associated with disease duration, disease location and possibly the presence of HSV DNA in the oral cavity...
June 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29479654/pemphigus-group-overview-epidemiology-mortality-and-comorbidities
#10
REVIEW
Khalaf Kridin
Pemphigus forms a group of rare autoimmune bullous diseases that affect the skin and mucous membranes. This group has a chronic course leading to high morbidity and mortality. It is characterized by the production of pathogenic autoantibodies directed against different proteins of the desmosome, leading histologically to intraepidermal cleavage, and clinically to vesicles and erosions on the epithelium of the mucous membranes and/or the skin. The diagnosis of the subtype of pemphigus is based on clinical features, the level of histologic cleavage, and the identification of the antigens recognized by circulating autoantibodies by immunoserological analyses...
April 2018: Immunologic Research
https://www.readbyqxmd.com/read/29469089/paraneoplastic-autoimmune-multi-organ-syndrome-is-a-distinct-entity-from-traditional-pemphigus-subtypes
#11
Kyle T Amber
No abstract text is available yet for this article.
February 22, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29469088/authors-reply-paraneoplastic-autoimmune-multi-organ-syndrome-is-a-distinct-entity-from-traditional-pemphigus-subtypes
#12
Aimee S Payne, Michael Kasperkiewicz, Christoph T Ellebrecht, Hayato Takahashi, Jun Yamagami, Detlef Zillikens, Masayuki Amagai
No abstract text is available yet for this article.
February 22, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29447659/paraneoplastic-pemphigus-in-a-34-year-old
#13
Laura E Melnick, Jenna M Beasley, Randi Kim, Nooshin Brinster, Kristen Lo Sicco
Paraneoplastic Pemphigus (PNP) is a rare and often fatal autoimmune mucocutaneous blistering disease associated with an underlying malignancy. It is thought to be caused by antibodies to tumor antigenscross-reacting with epithelial antigens, specifically desmosomal and hemidesmosomal antigens. There are at least five clinical morphologic variants of PNP, with the earliest and most consistent finding beingsevere stomatitis. Diagnosis of PNP requires direct immunofluorescence of perilesional skin and indirect immunofluorescence...
December 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29447653/rituximab-and-intravenous-immunoglobulin-as-alternatives-to-long-term-systemic-corticosteroids-in-the-treatment-of-pemphigus-a-single-center-case-series-of-63-patients
#14
COMPARATIVE STUDY
Ashley E Brown, Kiran Motaparthi, Sylvia Hsu
Rituximab and intravenous immunoglobulin [IVIg] have recently emerged as effective treatments for pemphigus refractory to corticosteroids [CS]. This case series sought to compare the clinical, serologic,and adverse effects of CS, IVIg, and rituximab in patients with pemphigus. A retrospective review of 63 patients with pemphigus vulgaris (PV), pemphigus foliaceus (PF), or paraneoplastic pemphigus (PNP)was performed. Clinical remission (CR), serologic remission (SR), and adverse effects were evaluated. Three study groups were compared: patients treated with systemic CS, refractory patients treated withIVIg, and refractory patients treated with rituximab...
January 19, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29389687/tocilizumab-cannot-prevent-the-development-of-bronchiolitis-obliterans-in-patients-with-castleman-disease-associated-paraneoplastic-pemphigus
#15
Liyang Gu, Shuang Ye
No abstract text is available yet for this article.
February 1, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29387753/paraneoplastic-pemphigus-mimicking-toxic-epidermal-necrolysis-an-underdiagnosed-entity
#16
R Matthew McLarney, Rodrigo H Valdes-Rodriguez, Gabriel Isaza-Gonzalez, Jason H Miller, Sylvia Hsu, Kiran Motaparthi
No abstract text is available yet for this article.
January 2018: JAAD Case Reports
https://www.readbyqxmd.com/read/29204394/paraneoplastic-pemphigus-with-underlying-retroperitoneal-inflammatory-myofibroblastic-tumor-a-case-report-and-review-of-the-literature
#17
Mohammad Shahidi-Dadras, Fahimeh Abdollahimajd, Nasibeh Barzkar, Zahra Asadi Kani, Mohammad Nikvar
Inflammatory myofibroblastic tumor (IMT) is a peculiar low-grade neoplasm of spindle cell fibroblasts and myofibroblasts in an inflammatory background. The lung is the most common site of involvement. Here, we report a case of paraneoplastic pemphigus (PNP)-associated with an extensive retroperitoneal IMT. The patient had a favourable response following treatment with a low dose of systemic steroid, mycophenolate mofetil, and intravenous immunoglobulin (IVIG). He subsequently underwent surgery for resection of the tumor with nephrectomy and five courses of IVIG were administered after surgery due to a minor relapse...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29198780/pemphigus-and-hematologic-malignancies-a-population-based-study-of-11-859-patients
#18
Khalaf Kridin, Shira Zelber-Sagi, Doron Comaneshter, Erez Batat, Arnon D Cohen
BACKGROUND: The association of nonparaneoplastic pemphigus with comorbid hematologic malignancies has yet to be established. OBJECTIVE: To estimate the association between pemphigus and the common types of hematologic malignancies. METHODS: A cross-sectional study was conducted comparing pemphigus patients with age-, sex- and ethnicity-matched control subjects regarding the prevalence of 6 comorbid hematologic malignancies. The study was performed using the computerized database of Clalit Health Services ensuring the availability of 4...
December 2, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29186863/paraneoplastic-pemphigus-insight-into-the-autoimmune-pathogenesis-clinical-features-and-therapy
#19
REVIEW
Giovanni Paolino, Dario Didona, Giuseppe Magliulo, Giannicola Iannella, Biagio Didona, Santo Raffaele Mercuri, Elisa Moliterni, Michele Donati, Andrea Ciofalo, Guido Granata, Patricia Ranuzzi, Vincenzo Falasca, Stefano Calvieri
Paraneoplastic pemphigus is a rare autoimmune skin disease that is always associated with a neoplasm. Usually, oral, skin, and mucosal lesions are the earliest manifestations shown by paraneoplastic pemphigus patients. The pathogenesis of paraneoplastic pemphigus is not yet completely understood, although some immunological aspects have been recently clarified. Because of its rarity, several diagnostic criteria have been proposed. Besides, several diagnostic procedures have been used for the diagnosis, including indirect immunofluorescence, direct immunofluorescence, and ELISA...
November 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28877826/clinical-analysis-of-unicentric-castleman-s-disease-with-paraneoplastic-pemphigus-and-bronchiolitis-obliterans
#20
Jun-Feng Zhen, Lu Zhang, Xin-Xin Cao, Jun Feng, Dao-Bin Zhou, Song-Bai Lin, Jian Li
Objective To investigate the clinical features of unicentric Castleman's disease(UCD)with paraneoplastic pemphigus(PNP)and bronchiolitis obliterans(BO).Method Data of UCD patients with PNP and BO from Peking Union Medical College Hospital were retrospectively analyzed,along with literatures review. Results Totally 23 cases(11 males and 12 females)were enrolled.The median age was 31 years(13-56 years).The most common pathological type was hyaline-vascular variant(91.4%),and most tumors located in abdominopelvic cavity(69...
August 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
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