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https://www.readbyqxmd.com/read/29165653/transgenerational-effects-of-bisphenol-a-on-gene-expression-and-dna-methylation-of-imprinted-genes-in-brain
#1
Zuzana Drobná, Anne D Henriksen, Jennifer T Wolstenholme, Catalina Montiel, Philip S Lambeth, Stephen Shang, Erin P Harris, Changqing Zhou, Jodi A Flaws, Mazhar Adli, Emilie F Rissman
Bisphenol A (BPA) is a ubiquitous man-made endocrine disrupting compound (EDC). Developmental exposure to BPA changes behavioral and reproductive phenotypes and these effects can last for generations. We exposed embryos to BPA producing two lineages: controls and BPA-exposed. In the third generation (F3), brain tissues containing the preoptic area, the bed nucleus of the stria terminalis, and the anterior hypothalamus were collected. RNA sequencing (RNA-Seq) and subsequent data analyses revealed 50 differentially regulated genes in the brains of F3 juveniles from BPA- versus control-lineages...
November 17, 2017: Endocrinology
https://www.readbyqxmd.com/read/29165555/prenatal-exposure-to-di-2-ethylhexyl-phthalate-dehp-disrupts-ovarian-function-in-a-transgenerational-manner-in-female-mice
#2
Saniya Rattan, Emily Brehm, Liying Gao, Sarah Niermann, Jodi A Flaws
Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer found in polyvinyl chloride products such as vinyl flooring, plastic food containers, medical devices, and children's toys. DEHP is a ubiquitous environmental contaminant and is a known endocrine disrupting chemical. Little is known about the effects of prenatal DEHP exposure on the ovary and whether effects occur in subsequent generations. Thus, we tested the hypothesis that prenatal exposure to DEHP disrupts ovarian functions in the F1, F2, and F3 generations of female mice...
November 20, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29150410/lung-function-in-early-adulthood-and-health-in-later-life-a-transgenerational-cohort-analysis
#3
Alvar Agustí, Guillaume Noell, Josep Brugada, Rosa Faner
BACKGROUND: Early life events can affect health in later life. We hypothesised that low lung function (FEV1 <80% predicted) in early adulthood (25-40 years) is associated with higher prevalence and earlier incidence of respiratory, cardiovascular, and metabolic abnormalities, and premature death. METHODS: In this cohort analysis, we tested this hypothesis using data from the Framingham Offspring Cohort (FOC) and validated our observations in CARDIA (an independent cohort) and GenIII (which includes the direct descendants of FOC participants)...
November 14, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29149482/melatonin-alleviates-low-ps-i-limited-carbon-assimilation-under-elevated-co2-and-enhances-the-cold-tolerance-of-offspring-in-chlorophyll-b-deficient-mutant-wheat
#4
Xiangnan Li, Marian Brestic, Dun-Xian Tan, Marek Zivcak, Xiancan Zhu, Shengqun Liu, Fengbin Song, Russel J Reiter, Fulai Liu
Melatonin is involved in the regulation of carbohydrate metabolism and induction of cold tolerance in plants. The objective of this study was to investigate the roles of melatonin in modulation of carbon assimilation of wild type wheat and the Chl b-deficient mutant ANK32B in response to elevated CO2 concentration ([CO2 ]) and the transgenerational effects of application of exogenous melatonin (hereafter identified as melatonin priming) on the cold tolerance in offspring. The results showed that the melatonin priming enhanced the carbon assimilation in ANK32B under elevated [CO2 ], via boosting the activities of ATPase and sucrose synthesis and maintaining a relatively higher level of total chlorophyll concentration in leaves...
November 17, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29147574/generational-comparisons-f1-versus-f3-of-vinclozolin-induced-epigenetic-transgenerational-inheritance-of-sperm-differential-dna-methylation-regions-epimutations-using-medip-seq
#5
Daniel Beck, Ingrid Sadler-Riggleman, Michael K Skinner
Environmentally induced epigenetic transgenerational inheritance of disease and phenotypic variation has been shown to involve DNA methylation alterations in the germline (e.g. sperm). These differential DNA methylation regions (DMRs) are termed epimutations and in part transmit the transgenerational phenotypes. The agricultural fungicide vinclozolin exposure of a gestating female rat has previously been shown to promote transgenerational disease and epimutations in F3 generation (great-grand-offspring) animals...
July 2017: Environmental Epigenetics
https://www.readbyqxmd.com/read/29143536/time-for-a-new-zeitgeist-in-perinatal-mental-health
#6
Fiona Judd, Louise Kathryn Newman, Angela A Komiti
Perinatal depression, and to a lesser extent anxiety, has been the focus of interest for perinatal psychiatrists for several decades. Policy and substantial funding has supported this. We argue that it is now time to change this focus and to invest greater funding to support clinical and research effort in 'high-risk' caregivers and their infants. We define high-risk caregivers as those who are likely to have attachment and relationship difficulties with their infant as a result of their own developmental experiences, personality difficulties and/or trauma-related mental disorders, often complicated by substance abuse, depression and anxiety...
November 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29129606/transgenerational-blunting-of-morphine-induced-corticosterone-secretion-is-associated-with-dysregulated-gene-expression-in-male-offspring
#7
Fair M Vassoler, Anika M Toorie, Elizabeth M Byrnes
A number of parental experiences, even when occurring prior to conception, have been shown to induce transgenerational effects beyond the first generation. In the case of exposure to drugs of abuse, studies in rodents suggest that offspring demonstrate significant differences in how they respond to the drug to which their parent was exposed. We have previously observed significant alterations in morphine analgesia, conditioned place preference and self-administration in the offspring of females exposed to morphine during adolescent development...
November 9, 2017: Brain Research
https://www.readbyqxmd.com/read/29129155/transgenerational-inheritance-of-familial-lipomyelomeningocele
#8
Thomas Larrew, Ramin Eskandari, Kenton R Holden, Amy Chen, Catherine J Spellicy, Julie R Jones, Jennifer A Lee, Michael J Lyons
Lipomyelomeningocele is a type of neural tube defect characterized by lipomatous tissue causing a defect in the vertebrae, infiltrating the dura, and tethering the spinal cord. Despite significant neurologic consequences, the underlying etiology remains poorly understood. We present a father and son with remarkably similar presentations of lipomyelomeningocele. Genetic testing did not reveal an underlying cause but whole exome sequencing identified variants in the ARHGAP29 and RADIL genes in the proband and his affected father...
December 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/29126411/thermal-conditions-during-early-life-influence-seasonal-maternal-strategies-in-the-three-spined-stickleback
#9
Sin-Yeon Kim, Neil B Metcalfe, Alberto da Silva, Alberto Velando
BACKGROUND: Conditions experienced by a female during early life may affect her reproductive strategies and maternal investment later in life. This effect of early environmental conditions is a potentially important mechanism by which animals can compensate for the negative impacts of climate change. In this study, we experimentally tested whether three-spined sticklebacks (Gasterosteus aculeatus) change their maternal strategy according to environmental temperatures experienced earlier in life...
November 10, 2017: BMC Ecology
https://www.readbyqxmd.com/read/29119291/determination-of-histone-epigenetic-marks-in-arabidopsis-and-tomato-genes-in-the-early-response-to-botrytis-cinerea
#10
Óscar Crespo-Salvador, Mónica Escamilla-Aguilar, Jaime López-Cruz, Gerardo López-Rodas, Carmen González-Bosch
Determination of histone epigenetic marks in Arabidopsis and tomato genes in the early response to Botrytis cinerea may contribute to find biomarkers of the early detection of this devastating pathogen. Recent studies have linked epigenetic modifications with plant responses to biotic stresses. Information about specific histone marks upon necrotrophic pathogens is scarce. Here we wondered whether the altered responsiveness of specific genes in plants infected with Botrytis cinerea was associated with changes in chromatin structure...
November 8, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/29112878/reproductive-and-endocrine-disrupting-toxicity-of-microcystis-aeruginosa-in-female-zebrafish
#11
Guangfu Liu, Mingjing Ke, Xiaoji Fan, Meng Zhang, Youchao Zhu, Tao Lu, Liwei Sun, Haifeng Qian
Microcystis aeruginosa, a primary species in cyanobacterial blooms, is ubiquitously distributed in water. Microcystins (MCs) purified from M. aeruginosa can exert reproductive toxicity in fish. However, the effects of M. aeruginosa at environmentally relevant levels on the reproductive and endocrine systems of zebrafish are still unknown. The present study investigated the reproductive and endocrine-disrupting toxicity of M. aeruginosa on female zebrafish (Danio rerio) by short-term exposure (96 h). After exposure, marked histological lesions in the liver or gonads, such as nuclear pyknosis and deformation, were observed, and the fertilization rate and hatchability of eggs spawned from treated females were both significantly lower than they were in females in the control group, suggesting the possibility of transgenerational effects of M...
November 1, 2017: Chemosphere
https://www.readbyqxmd.com/read/29111290/-transgenerational-impact-of-chemotherapy-would-the-father-exposure-impact-the-health-of-future-progeny
#12
A Tremblay, H Beaud, G Delbès
The number of cancer survivors is increasing and their quality of life is becoming a major public health issue. Cancer treatments reduce men's reproductive health by targeting spermatogenesis. Ultimately, DNA, chromatin and the epigenome of spermatozoa can be altered in cancer survivors. Knowing whether the history of cancer and the treatments received can have consequences on the health of their offspring is therefore a fundamental question for these patients. This review gathers the experimental and epidemiological evidences of the effects observed on the direct descendants and on several generations, and draws up the state of knowledge on the mechanisms potentially involved...
October 27, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29109696/low-dose-alkylphenol-exposure-promotes-mammary-epithelium-alterations-and-transgenerational-developmental-defects-but-does-not-enhance-tumorigenic-behavior-of-breast-cancer-cells
#13
Clémence Chamard-Jovenin, Charlène Thiebaut, Amand Chesnel, Emmanuel Bresso, Chloé Morel, Malika Smail-Tabbone, Marie-Dominique Devignes, Taha Boukhobza, Hélène Dumond
Fetal and neonatal exposure to long-chain alkylphenols has been suspected to promote breast developmental disorders and consequently to increase breast cancer risk. However, disease predisposition from developmental exposures remains unclear. In this work, human MCF-10A mammary epithelial cells were exposed in vitro to a low dose of a realistic (4-nonylphenol + 4-tert-octylphenol) mixture. Transcriptome and cell-phenotype analyses combined to functional and signaling network modeling indicated that long-chain alkylphenols triggered enhanced proliferation, migration ability, and apoptosis resistance and shed light on the underlying molecular mechanisms which involved the human estrogen receptor alpha 36 (ERα36) variant...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29106518/prenatal-ethanol-exposure-and-neocortical-development-a-transgenerational-model-of-fasd
#14
Charles W Abbott, David J Rohac, Riley T Bottom, Sahil Patadia, Kelly J Huffman
Fetal Alcohol Spectrum Disorders, or FASD, represent a range of adverse developmental conditions caused by prenatal ethanol exposure (PrEE) from maternal consumption of alcohol. PrEE induces neurobiological damage in the developing brain leading to cognitive-perceptual and behavioral deficits in the offspring. Alcohol-mediated alterations to epigenetic function may underlie PrEE-related brain dysfunction, with these changes potentially carried across generations to unexposed offspring. To determine the transgenerational impact of PrEE on neocortical development, we generated a mouse model of FASD and identified numerous stable phenotypes transmitted via the male germline to the unexposed third generation...
July 6, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29103876/intergenerational-transmission-of-gene-regulatory-information-in-caenorhabditis-elegans
#15
REVIEW
Olga Minkina, Craig P Hunter
Epigenetic mechanisms can stably maintain gene expression states even after the initiating conditions have changed. Often epigenetic information is transmitted only to daughter cells, but evidence is emerging, in both vertebrate and invertebrate systems, for transgenerational epigenetic inheritance (TEI), the transmission of epigenetic gene regulatory information across generations. Each new description of TEI helps uncover the properties, molecular mechanisms and biological roles for TEI. The nematode Caenorhabditis elegans has been particularly instrumental in the effort to understand TEI, as multiple environmental and genetic triggers can initiate an epigenetic signal that can alter the expression of both transgenes and endogenous loci...
November 2, 2017: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/29096770/what-are-the-transgenerational-consequences-of-maternal-childhood-adversity-and-maternal-stress-during-pregnancy
#16
EDITORIAL
James F Leckman
No abstract text is available yet for this article.
November 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29094774/perinatal-maternal-depressive-symptoms-alter-amygdala-functional-connectivity-in-girls
#17
Ni Ni Soe, Daniel J Wen, Joann S Poh, Yap-Seng Chong, Birit Fp Broekman, Helen Chen, Lynette P Shek, Kok Hian Tan, Peter D Gluckman, Marielle V Fortier, Michael J Meaney, Anqi Qiu
Perinatal maternal depressive symptoms influence brain development of offspring. Such effects are particularly notable in the amygdala, a key structure involved in emotional processes. This study investigated whether the functional organization of the amygdala varies as a function of pre- and postnatal maternal depressive symptoms. The amygdala functional network was assessed using resting-state functional magnetic resonance imaging (rs-fMRI) in 128 children at age of 4.4 to 4.8 years. Maternal depressive symptoms were obtained at 26 weeks of gestation, 3 months, 1, 2, 3, and 4...
November 2, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29094667/the-effects-of-a-reduced-balanced-protein-diet-on-litter-moisture-pododermatitis-and-feather-condition-of-female-broiler-breeders-over-three-generations
#18
C Li, J Lesuisse, S Schallier, W Clímaco, Y Wang, A Bautil, N Everaert, J Buyse
Protein content reduction in broiler breeder diets has been increasingly investigated. However, broiler breeders reared on low protein diets are characterized by a deterioration of the feather condition. Furthermore, polydipsia induced by controlled feed intake increases litter moisture and as a consequence pododermatitis. This project aimed to study the litter moisture, pododermatitis and feather condition of breeders fed with a 25% reduced balanced protein (RP) diet during the rearing and laying period over three successive generations...
November 2, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29084191/therapy-of-a-couple-with-a-bipolar-spouse
#19
Andrzej Witusik, Tadeusz Pietras
Qualitative analysis of therapy of a couple with a partner who has bipolar disorder is an important research paradigm in contemporary psychotherapy of mental disorders.The qualitative method of the study is important both from the cognitive point of view and for the evaluation of the therapeutic efficacy in the individual, idiographical aspect. AIM: The aim of the study is a qualitative analysis of the therapeutic process of a couple in which one partner suffers from bipolar affective disorder...
October 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29080023/bidirectional-effects-of-mother-young-contact-on-the-maternal-and-neonatal-brains
#20
Gabriela González-Mariscal, Angel I Melo
Adaptive plasticity occurs intensely during the early postnatal period through processes like proliferation, migration, differentiation, synaptogenesis, myelination and apoptosis. Exposure to particular stimuli during this critical period has long-lasting effects on cognition, stress reactivity and behavior. Maternal care is the main source of social, sensory and chemical stimulation to the young and is, therefore, critical to "fine-tune" the offspring's neural development. Mothers providing a low quantity or quality of stimulation produce offspring that will exhibit reduced cognitive performance, impaired social affiliation and increased agonistic behaviors...
2017: Advances in Experimental Medicine and Biology
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