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https://www.readbyqxmd.com/read/28816621/use-disuse-paradigms-are-ubiquitous-concepts-in-characterizing-the-process-of-inheritance
#1
Sophie Juliane Veigl
In recent years, a Lamarckian theme has found its way back into academic discourse on evolution and inheritance. Especially the emerging field of transgenerational small RNAs has provided at least a proof of concept for the inheritance of acquired traits. Yet it remains unclear whether the Lamarckian concept of inheritance will in fact have its rennaisance or whether it will remain the rallying cry for the outlaws, heretics and enfants terribles of molecular biology. As unclear as the future of Lamarckian theory is its content and reference...
August 17, 2017: RNA Biology
https://www.readbyqxmd.com/read/28807754/transgenerational-effects-of-early-environmental-insults-on-aging-and-disease-incidence
#2
REVIEW
Mirela Ambeskovic, Tessa J Roseboom, Gerlinde A S Metz
Adverse early life experiences are major influences on developmental trajectories with potentially life-long consequences. Prenatal or early postnatal exposure to stress, undernutrition or environmental toxicants may reprogram brain development and increase risk of behavioural and neurological disorders later in life. Not only experience within a single lifetime, but also ancestral experience affects health trajectories and chances of successful aging. The central mechanism in transgenerational programming of a disease may the formation of epigenetic memory...
August 11, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28806546/parental-exposure-to-bisphenol-a-and-its-analogs-influences-zebrafish-offspring-immunity
#3
Xing Dong, Zhen Zhang, Shunlong Meng, Chenyuan Pan, Ming Yang, Xiangyang Wu, Liuqing Yang, Hai Xu
Transgenerational effects of environmental pollutants on humans and animals are complex. Thus, we used zebrafish to evaluate the effects of parental whole-life cycle exposure to bisphenol A and its analogs (bisphenol S and F) on offspring innate immunity. At adulthood, offspring were examined with/without continued chemicals treatment until 72h post-fertilization (hpf). To measure offspring immune function, larvae at 72 hpf were expose for 24h with/without the viral mimic polyinosinic-cytidylic acid (Poly I:C) or the bacterial mimic Pam3Cys-Ser-Lys4 (PAM3CSK4)...
August 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28805197/family-of-a-person-suffering-from-schizophrenia-in-the-context-of-a-qualitative-approach-to-understanding-the-family-as-a-system
#4
Andrzej Witusik
Qualitative analysis of the family system including a person suffering from schizophrenia is an underestimated research paradigm in modern psychiatry, clinical psychology and psychotherapy. This method is important both from the cognitive point of view and for evaluation of the effectiveness of therapy. AIM: The aim of the study was a qualitative analysis of the therapeutic process in a family whose member is suffering from schizophrenic psychosis. MATERIALS AND METHODS: The study of the process using qualitative research methodology in the paradigm of systemic thinking pointing to the mutual interactions in the family system inducing relapses in the identified patient, with identification of triangulation processes, transgenerational myths inheritance and coalitions formed by the family members...
July 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28797480/can-acclimation-of-thermal-tolerance-in-adults-and-across-generations-act-as-a-buffer-against-climate-change-in-tropical-marine-ectotherms
#5
S A Morley, K D Nguyen, L S Peck, C-H Lai, K S Tan
Thermal acclimation capacity was investigated in adults of three tropical marine invertebrates, the subtidal barnacle Striatobalanus amaryllis, the intertidal gastropod Volegalea cochlidium and the intertidal barnacle Amphibalanus amphitrite. To test the relative importance of transgenerational acclimation, the developmental acclimation capacity of A. amphitrite was investigated in F1 and F2 generations reared at a subset of the same incubation temperatures. The increase in CTmax (measured through loss of key behavioural metrics) of F0 adults across the incubation temperature range 25...
August 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28795474/endocrine-disruption-in-aquatic-systems-up-scaling-research-to-address-ecological-consequences
#6
Fredric M Windsor, Steve J Ormerod, Charles R Tyler
Endocrine-disrupting chemicals (EDCs) can alter biological function in organisms at environmentally relevant concentrations and are a significant threat to aquatic biodiversity, but there is little understanding of exposure consequences for populations, communities and ecosystems. The pervasive nature of EDCs within aquatic environments and their multiple sub-lethal effects make assessments of their impact especially important but also highly challenging. Herein, we review the data on EDC effects in aquatic systems focusing on studies assessing populations and ecosystems, and including how biotic and abiotic processes may affect, and be affected by, responses to EDCs...
August 9, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28794174/maternal-western-diet-age-specifically-alters-female-offspring-voluntary-physical-activity-and-dopamine-and-leptin-related-gene-expression
#7
Gregory N Ruegsegger, Kolter B Grigsby, Taylor J Kelty, Terese M Zidon, Thomas E Childs, Victoria J Vieira-Potter, David L Klinkebiel, Michael Matheny, Phillip J Scarpace, Frank W Booth
Prenatal overnutrition affects development into adulthood and influences risk of obesity. We assessed the transgenerational effect of maternal Western diet (WD) consumption on offspring physical activity. Voluntary wheel running was increased in juvenile (4-7 wk of age), but decreased in adult (16-19 wk of age), F1 female WD offspring In contrast, no wheel-running differences in F1 male offspring were observed. Increased wheel running in juvenile female WD offspring was associated with up-regulated dopamine receptor (DRD)-1 and -2 in the nucleus accumbens (NAc) and with down-regulated Lepr in the ventral tegmental area (VTA)...
August 9, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28779964/the-c-elegans-set-2-set1-histone-h3-lys4-h3k4-methyltransferase-preserves-genome-stability-in-the-germline
#8
M Herbette, M G Mercier, F Michal, D Cluet, C Burny, G Yvert, V J Robert, F Palladino
Maintaining the integrity of genetic information across generations is essential for both cell survival and reproduction, and requires the timely repair of DNA damage. Histone-modifying enzymes play a central role in the DNA repair process through the deposition and removal of post-translational modifications on the histone tails. Specific histone modification act in the DNA repair process through the recruitment of proteins and complexes with specific enzymatic activities, or by altering the chromatin state at the site of DNA lesions...
July 29, 2017: DNA Repair
https://www.readbyqxmd.com/read/28770062/transgenerational-plasticity-as-an-important-mechanism-affecting-response-of-clonal-species-to-changing-climate
#9
Zuzana Münzbergová, Věroslava Hadincová
In spite of the increasing number of studies on the importance of transgenerational plasticity for species response to novel environments, its effects on species ability to respond to climate change are still largely unexplored. We study the importance of transgenerational plasticity for response of a clonal species Festuca rubra. Individuals from four natural populations representing two levels of temperature and two levels of precipitation were cultivated in four growth chambers that simulate the temperature and precipitation of origin of the populations (maternal phase)...
July 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28764606/low-dose-radiation-induced-risk-in-spermatogenesis
#10
Hisanori Fukunaga, Karl T Butterworth, Akinari Yokoya, Takehiko Ogawa, Kevin M Prise
PURPOSE: To discuss low-dose radiation-induced risks to male fertility focusing on potential mechanisms of low-dose radiation-induced damage on spermatogenesis, epidemiological studies of environmental radiation effects on sperm parameters and transgenerational effects following exposure of spermatogonial stem cells (SSCs). BACKGROUND: Spermatogenesis produces mature male gametes, spermatozoa, which fertilize their counterpart female gametes, oocytes. The robust maintenance system of spermatogenesis is essential for genomic conservation; however, male fertility can be readily impacted by exposure to environmental, chemical and physical factors including ionizing radiation...
August 2, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28763935/parental-exposure-to-microcystin-lr-induced-thyroid-endocrine-disruption-in-zebrafish-offspring-a-transgenerational-toxicity
#11
Houcheng Cheng, Wei Yan, Qin Wu, Chunsheng Liu, Xiuying Gong, Tien-Chieh Hung, Guangyu Li
Microcystin-LR is the most poisonous and commonly encountered hepatotoxin produced by cyanobacteria in an aquatic ecosystem, and it may cause thyroid dysfunction in fish. The present study aimed to reveal the effects of transgenerational toxicity of MCLR on the thyroid endocrine system under sub-chronic exposure conditions. Adult zebrafish (F0) were exposed to environmentally relevant concentrations (1, 5 and 25 μg/L) of MCLR for 45 days. The produced F1 embryos were then tested without further MCLR treatment...
July 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28761010/the-placental-gateway-of-maternal-transgenerational-epigenetic-inheritance
#12
S Purnima Sailasree, Surabhi Srivastava, Rakesh K Mishra
While much of our understanding of genetic inheritance is based on the genome of the organism, it is becoming clear that there is an ample amount of epigenetic inheritance, which though reversible, escapes erasing process during gametogenesis and goes on to the next generation. Several examples of transgenerational inheritance of epigenetic features with potential impact on embryonic development and subsequent adult life have come to light. In placental mammals, the placenta is an additional route for epigenetic information flow...
July 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28761008/epigenetic-inheritance-prions-and-evolution
#13
Johannes Manjrekar
The field of epigenetics has grown explosively in the past two decades or so. As currently defined, epigenetics deals with heritable, metastable and usually reversible changes that do not involve alterations in DNA sequence, but alter the way that information encoded inDNAis utilized.The bulk of current research in epigenetics concerns itself with mitotically inherited epigenetic processes underlying development or responses to environmental cues (as well as the role of mis-regulation or dys-regulation of such processes in disease and ageing), i...
July 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28758839/is-there-a-transgenerational-inheritance-of-host-resistance-against-pathogens-lessons-from-the-galleria-mellonella-bacillus-thuringiensis-interaction-model
#14
Hélène Bierne, Christina Nielsen-LeRoux
No abstract text is available yet for this article.
July 31, 2017: Virulence
https://www.readbyqxmd.com/read/28753980/transgenerational-social-stress-alters-immune-behavior-associations-and-the-response-to-vaccination
#15
Alexandria Hicks-Nelson, Gillian Beamer, Kursat Gurel, Rachel Cooper, Benjamin C Nephew
Similar to the multi-hit theory of schizophrenia, social behavior pathologies are mediated by multiple factors across generations, likely acting additively, synergistically, or antagonistically. Exposure to social adversity, especially during early life, has been proposed to induce depression symptoms through immune mediated mechanisms. Basal immune factors are altered in a variety of neurobehavioral models. In the current study, we assessed two aspects of a transgenerational chronic social stress (CSS) rat model and its effects on the immune system...
July 21, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28750703/translational-perspective-on-epigenetics-in%C3%A2-cardiovascular-disease
#16
REVIEW
Pim van der Harst, Leon J de Windt, John C Chambers
A plethora of environmental and behavioral factors interact, resulting in changes in gene expression and providing a basis for the development and progression of cardiovascular diseases. Heterogeneity in gene expression responses among cells and individuals involves epigenetic mechanisms. Advancing technology allowing genome-scale interrogation of epigenetic marks provides a rapidly expanding view of the complexity and diversity of the epigenome. In this review, the authors discuss the expanding landscape of epigenetic modifications and highlight their importance for future understanding of disease...
August 1, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28750655/non-genomic-transmission-of-longevity-between-generations-potential-mechanisms-and%C3%A2-evidence-across-species
#17
REVIEW
Alexander M Vaiserman, Alexander K Koliada, Randy L Jirtle
Accumulating animal and human data indicate that environmental exposures experienced during sensitive developmental periods may strongly influence risk of adult disease. Moreover, the effects triggered by developmental environmental cues can be transgenerationally transmitted, potentially affecting offspring health outcomes. Increasing evidence suggests a central role of epigenetic mechanisms (heritable alterations in gene expression occurring without changes in underlying DNA sequence) in mediating these effects...
July 27, 2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28750172/transgenerational-modification-of-hippocampus-tnf-%C3%AE-and-s100b-levels-in-the-offspring-of-rats-chronically-exposed-to-morphine-during-adolescence
#18
Jamal Amri, Mehdi Sadegh, Neda Moulaei, Mohammad Reza Palizvan
BACKGROUND: TNF-α and S100B are important signaling factors that are involved in many aberrant conditions of the brain. Chronic morphine exposure causes aberrant modifications in the brain. OBJECTIVES: We examined the consequences of chronic morphine consumption by parents before mating on hippocampus TNF-α and S100B levels in the parents and their offspring. METHODS: A total of 12 adult female and 12 adult male Wistar rats were used as parents...
July 27, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28747973/effect-of-ionizing-radiation-at-low-dose-on-transgenerational-carcinogenesis-by-epigenetic-regulation
#19
Lan Li, Jong-Hyun Kim, Hee-Tae Park, Jae-Hoon Lee, Min-Koo Park, Ji-Won Lee, Jeong-Chan Lee, Min-Jae Lee
The objective of this study was to determine the effect of ionizing radiation (IR) exposure of parents on carcinogenesis of the next generation focusing on the epigenetic perspective to clarify the relationship between radiation dose and carcinogenesis in F1 generation SD rats. F1 generations from pregnant rats (F0) who were exposed to gamma rays were divided into three groups according to the dose of radiation: 10 rad, 30 rad, and untreated. They were intraperitoneally injected with 50 mg/kg of diethylnitrosamine (DEN)...
June 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28745897/incorporating-transgenerational-epigenetic-inheritance-into-ecological-risk-assessment-frameworks
#20
Jennifer L A Shaw, Jonathan D Judy, Anupama Kumar, Paul Bertsch, Ming-Bo Wang, Jason K Kirby
Chronic exposure to environmental contaminants can induce heritable 'transgenerational' modifications to organisms, potentially affecting future ecosystem health and functionality. Incorporating transgenerational epigenetic heritability into risk assessment procedures has been previously suggested. However, a critical review of existing literature yielded numerous studies claiming transgenerational impacts, with little compelling evidence. Therefore, contaminant-induced epigenetic inheritance may be less common than is reported in the literature...
July 26, 2017: Environmental Science & Technology
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