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https://www.readbyqxmd.com/read/28938459/selective-glucocorticoid-receptor-antagonist-cort125281-activates-brown-adipose-tissue-and-alters-lipid-distribution-in-male-mice
#1
Jan Kroon, Lisa L Koorneef, Jose K van den Heuvel, Cristy R C Verzijl, Nienke M van de Velde, Isabel M Mol, Hetty C M Sips, Hazel Hunt, Patrick C N Rensen, Onno C Meijer
Glucocorticoids influence a wide range of metabolic processes in the human body and excessive glucocorticoid exposure is known to contribute to the development of metabolic disease. We evaluated the utility of the novel glucocorticoid receptor (GR) antagonist CORT125281 for its potential to overcome adiposity, glucose intolerance and dyslipidaemia, and compared this head-to-head with classic GR antagonist RU486 (mifepristone). We show that, while RU486 displays cross-reactivity to the progesterone and androgen receptor, CORT125281 selectively inhibits GR transcriptional activity...
September 18, 2017: Endocrinology
https://www.readbyqxmd.com/read/28935167/impact-of-lifetime-traumatic-experiences-on-suicidality-and-likelihood-of-conversion-in-a-cohort-of-individuals-at-clinical-high-risk-for-psychosis
#2
Margaux M Grivel, Wei Leong, Michael D Masucci, Rebecca A Altschuler, Leigh Y Arndt, Samantha L Redman, Lawrence H Yang, Gary Brucato, Ragy R Girgis
Recent research suggests that trauma history (TH) is a strong socio-environmental risk factor for the development of psychosis. While reported rates of childhood trauma are higher among individuals at clinical high-risk (CHR) for psychosis than in the general population, little research has explored the effects of trauma upon the severity of attenuated positive symptoms. We aimed to explore the specific relationships between TH and baseline symptom severity; likelihood of conversion to full-blown psychosis; suicidal ideation (SI); and suicidal behavior (SB) in a cohort of 200 help-seeking CHR individuals...
September 18, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28934136/the-application-of-functionalized-pillared-porous-phosphate-heterostructures-for-the-removal-of-textile-dyes-from-wastewater
#3
José Jiménez-Jiménez, Manuel Algarra, Vanessa Guimarães, Iuliu Bobos, Enrique Rodríguez-Castellón
A synthesized functionalized pillared porous phosphate heterostructure (PPH), surface functionalized phenyl group, has been used to remove the dye Acid Blue 113 from wastewater. X-ray photoemission spectroscopy XPS and X-ray diffraction (XRD) were used to study its structure. The specific surface area of this was 498 m²/g. The adsorption capacities of PPH and phenyl surface functionalized (Φ-PPH) were 0.0400 and 0.0967 mmol/g, respectively, with a dye concentration of 10(-5) M when well fitted with SIPS and Langmuir isotherms respectively (pH 6...
September 21, 2017: Materials
https://www.readbyqxmd.com/read/28933820/considerations-for-safe-innovation-the-case-of-graphene
#4
Margriet V D Z Park, Eric A J Bleeker, Walter Brand, Flemming R Cassee, Merel van Elk, Ilse Gosens, Wim H De Jong, Johannes A J Meesters, Willie Jgm Peijnenburg, Joris T K Quik, Rob J Vandebriel, Adrienne J A M Sips
The terms 'Safe innovation' and 'Safe(r)-by-design' are currently popular in the field of nanotechnology. These terms are used to describe approaches that advocate the consideration of safety aspects already at an early stage of the innovation process of (nano)materials and nano-enabled products. Here, we investigate the possibilities of considering safety aspects during various stages of the innovation processes based on of graphene, outlining what information is already available for assessing potential hazard, exposure and risks...
September 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28931844/calibrated-link-budget-of-a-silicon-photonics-wdm-transceiver-with-soa-and-semiconductor-mode-locked-laser
#5
Alvaro Moscoso-Mártir, Juliana Müller, Elmira Islamova, Florian Merget, Jeremy Witzens
Based on the single channel characterization of a Silicon Photonics (SiP) transceiver with Semiconductor Optical Amplifier (SOA) and semiconductor Mode-Locked Laser (MLL), we evaluate the optical power budget of a corresponding Wavelength Division Multiplexed (WDM) link in which penalties associated to multi-channel operation and the management of polarization diversity are introduced. In particular, channel cross-talk as well as Cross Gain Modulation (XGM) and Four Wave Mixing (FWM) inside the SOA are taken into account...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923955/leaderless-secreted-peptide-signaling-molecule-alters-global-gene-expression-and-increases-virulence-of-a-human-bacterial-pathogen
#6
Hackwon Do, Nishanth Makthal, Arica R VanderWal, Mandy Rettel, Mikhail M Savitski, Nikolai Peschek, Kai Papenfort, Randall J Olsen, James M Musser, Muthiah Kumaraswami
Successful pathogens use complex signaling mechanisms to monitor their environment and reprogram global gene expression during specific stages of infection. Group A Streptococcus (GAS) is a major human pathogen that causes significant disease burden worldwide. A secreted cysteine protease known as streptococcal pyrogenic exotoxin B (SpeB) is a key virulence factor that is produced abundantly during infection and is critical for GAS pathogenesis. Although identified nearly a century ago, the molecular basis for growth phase control of speB gene expression remains unknown...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28919716/palatability-and-physical-properties-of-potassium-binding-resin-rdx7675-comparison-with-sodium-polystyrene-sulfonate
#7
Vanessa Zann, John McDermott, Jeffrey W Jacobs, James P Davidson, Fangling Lin, Paul Korner, Robert C Blanks, David P Rosenbaum
BACKGROUND: Hyperkalemia is a potentially life-threatening condition that patients with heart failure or chronic kidney disease, especially those taking renin-angiotensin-aldosterone system inhibitors, are at high risk of developing. Sodium polystyrene sulfonate (SPS), a current treatment, binds potassium within the gastrointestinal tract to reduce potassium absorption. However, poor palatability limits its long-term use. RDX7675, a novel potassium binder in development for the treatment of hyperkalemia, is a calcium salt of a reengineered polystyrene sulfonate-based resin designed to have enhanced palatability...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28918638/a-rapid-blood-test-to-determine-the-active-status-and-duration-of-acute-viral-infection
#8
Tianyu Zheng, Caroline Finn, Christopher J Parrett, Kunal Dhume, Ji Hae Hwang, David Sidhom, Tara M Strutt, Yuen Yee Li Sip, Karl K McKinstry, Qun Huo
The ability to rapidly detect and diagnose acute viral infections is crucial for infectious disease control and management. Serology testing for the presence of virus-elicited antibodies in blood is one of the methods used commonly for clinical diagnosis of viral infections. However, standard serology-based tests have a significant limitation: they cannot easily distinguish active from past, historical infections. As a result, it is difficult to determine whether a patient is currently infected with a virus or not, and on an optimal course of action, based off of positive serology testing responses...
September 20, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28918440/interpersonal-sensitivity-and-persistent-attenuated-psychotic-symptoms-in-adolescence
#9
Alice Masillo, M Brandizzi, L R Valmaggia, R Saba, N Lo Cascio, J F Lindau, L Telesforo, P Venturini, D Montanaro, D Di Pietro, M D'Alema, P Girardi, P Fiori Nastro
Interpersonal sensitivity defines feelings of inner-fragility in the presence of others due to the expectation of criticism or rejection. Interpersonal sensitivity was found to be related to attenuated positive psychotic symptom during the prodromal phase of psychosis. The aims of this study were to examine if high level of interpersonal sensitivity at baseline are associated with the persistence of attenuated positive psychotic symptoms and general psychopathology at 18-month follow-up. A sample of 85 help-seeking individuals (mean age = 16...
September 16, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28912088/sip-and-spit-or-sip-and-swallow-choice-of-method-differentially-alters-taste-intensity-estimates-across-stimuli
#10
Cordelia A Running, John E Hayes
While the myth of the tongue map has been consistently and repeatedly debunked in controlled studies, evidence for regional differences in suprathreshold intensity has been noted by multiple research groups. Given differences in physiology between the anterior and posterior tongue (fungiform versus foliate and circumvallate papillae) and differences in total area stimulated (anterior only versus whole tongue, pharynx, and epiglottis), small methodological changes (sip and spit versus sip and swallow) have the potential to substantially influence data...
September 11, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28901636/risk-analysis-and-technology-assessment-in-support-of-technology-development-putting-responsible-innovation-in-practice-in-a-case-study-for-nanotechnology
#11
Annemarie P van Wezel, Harro van Lente, Johannes J M van de Sandt, Hans Bouwmeester, Rens L J Vandeberg, Adrienne J A M Sips
Governments invest in 'key enabling technologies' such as nanotechnology, to solve societal challenges and boost the economy. At the same time governmental agencies demand for risk reduction to prohibit any often unknown adverse effects, and industrial parties demand for smart approaches to reduce uncertainties. Responsible research and innovation (RRI) is therefore a central theme in policy-making. Risk Analysis and Technology Assessment, together referred to as RATA, can provide a basis to assess human, environmental and societal risks of new technological developments during the various stages of technological development...
September 13, 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28895946/dna-sip-based-genome-centric-metagenomics-identifies-key-long-chain-fatty-acid-degrading-populations-in-anaerobic-digesters-with-different-feeding-frequencies
#12
Ryan M Ziels, Diana Z Sousa, H David Stensel, David A C Beck
Fats, oils and greases (FOG) are energy-dense wastes that can be added to anaerobic digesters to substantially increase biomethane recovery via their conversion through long-chain fatty acids (LCFAs). However, a better understanding of the ecophysiology of syntrophic LCFA-degrading microbial communities in anaerobic digesters is needed to develop operating strategies that mitigate inhibitory LCFA accumulation from FOG. In this research, DNA stable isotope probing (SIP) was coupled with metagenomic sequencing for a genome-centric comparison of oleate (C18:1)-degrading populations in two anaerobic codigesters operated with either a pulse feeding or continuous-feeding strategy...
September 12, 2017: ISME Journal
https://www.readbyqxmd.com/read/28886901/perceptual-abnormalities-in-clinical-high-risk-youth-and-the-role-of-trauma-cannabis-use-and-anxiety
#13
Yun Lu, Catherine Marshall, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Thomas H McGlashan, Diana O Perkins, Larry J Seidman, Ming T Tsuang, Elaine F Walker, Scott W Woods, Carrie E Bearden, Daniel Mathalon, Jean Addington
Recent research suggests that perceptual abnormalities are a group of diverse experiences, which have been associated with trauma, cannabis use, and anxiety. Of the attenuated psychotic symptoms that are present in youth at clinical high risk (CHR) of psychosis, perceptual abnormalities tend to be one of the most frequently endorsed symptoms. However, very few studies have explored perceptual abnormalities and their relationships with the above environmental and affective factors in a CHR sample. Four hundred and forty-one CHR individuals who met criteria for attenuated psychotic symptom syndrome (APSS) determined by the Structured Interview for Psychosis-risk Syndromes (SIPS) were assessed on the content of their perceptual abnormalities, early traumatic experience, cannabis use and self-reported anxiety...
August 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28879149/development-and-implementation-of-the-caribbean-laboratory-quality-management-systems-stepwise-improvement-process-lqms-sip-towards-accreditation
#14
George Alemnji, Lisa Edghill, Giselle Guevara, Sacha Wallace-Sankarsingh, Rachel Albalak, Sebastien Cognat, John Nkengasong, Jean-Marc Gabastou
BACKGROUND: Implementing quality management systems and accrediting laboratories in the Caribbean has been a challenge. OBJECTIVES: We report the development of a stepwise process for quality systems improvement in the Caribbean Region. METHODS: The Caribbean Laboratory Stakeholders met under a joint Pan American Health Organization/US Centers for Disease Control and Prevention initiative and developed a user-friendly framework called 'Laboratory Quality Management System - Stepwise Improvement Process (LQMS-SIP) Towards Accreditation' to support countries in strengthening laboratory services through a stepwise approach toward fulfilling the ISO 15189: 2012 requirements...
2017: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/28877846/environmental-surveillance-during-an-outbreak-of-tularaemia-in-hares-the-netherlands-2015
#15
Ingmar Janse, Miriam Maas, Jolianne M Rijks, Miriam Koene, Rozemarijn Qj van der Plaats, Marc Engelsma, Peter van der Tas, Marieta Braks, Arjan Stroo, Daan W Notermans, Maaike C de Vries, Frans Reubsaet, Ewout Fanoy, Corien Swaan, Marja Jl Kik, Jooske IJzer, Ryanne I Jaarsma, Sip van Wieren, Ana Maria de Roda-Husman, Mark van Passel, Hendrik-Jan Roest, Joke van der Giessen
Tularaemia, a disease caused by the bacterium Francisella tularensis, is a re-emerging zoonosis in the Netherlands. After sporadic human and hare cases occurred in the period 2011 to 2014, a cluster of F. tularensis-infected hares was recognised in a region in the north of the Netherlands from February to May 2015. No human cases were identified, including after active case finding. Presence of F. tularensis was investigated in potential reservoirs and transmission routes, including common voles, arthropod vectors and surface waters...
August 31, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28876259/powdered-grape-seeds-pgs-as-an-alternative-biosorbent-to-remove-pharmaceutical-dyes-from-aqueous-solutions
#16
Gabriel Vanni, Leticia Belén Escudero, Guilherme Luiz Dotto
An alternative, low-cost and efficient biosorbent, powdered grape seeds (PGS), was prepared from wastes of a wine industry, and used to remove brilliant blue (BB) and amaranth red (AR) dyes from aqueous solutions. The biosorbent was properly characterized before and after the biosorption operation. The potential of PGS to remove BB and AR dyes was investigated thought kinetic, isotherm and thermodynamic studies. The biosorption of BB and AR was favored at pH 1.0 using biosorbent dosage of 0.500 g L(-1), being attained more than 85% of removal percentage...
September 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28873685/consumer-perception-of-salt-reduced-breads-comparison-of-single-and-two-bites-evaluation
#17
Lucía Antúnez, Ana Giménez, Florencia Alcaire, Leticia Vidal, Gastón Ares
Salt-reduction in processed products has been proposed as a high-impact intervention for reducing the sodium intake at population level. A major limitation for this approach is its potential negative impact on the sensory characteristics of products. The current practice in sensory and consumer science involves single sip/bite evaluations, which may not properly reflect the sensory experience that occurs during product consumption. In this context, the aim of the present work was to compare single and two bite evaluations of consumer sensory and hedonic perception of salt-reduced breads...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28871500/computational-neuroanatomy-of-human-stratum-proprium-of-interparietal-sulcus
#18
Maiko Uesaki, Hiromasa Takemura, Hiroshi Ashida
Recent advances in diffusion-weighted MRI (dMRI) and tractography have enabled identification of major long-range white matter tracts in the human brain. Yet, our understanding of shorter tracts, such as those within the parietal lobe, remains limited. Over a century ago, a tract connecting the superior and inferior parts of the parietal cortex was identified in a post-mortem study: stratum proprium of interparietal sulcus (SIPS; Sachs, Das hemisphärenmark des menschlichen grosshirns. Verlag von georg thieme, Leipzig, 1892)...
September 4, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28870748/sulfated-polysaccharide-of-sepiella-maindroni-ink-inhibits-the-migration-invasion-and-matrix-metalloproteinase-2-expression-through-suppressing-egfr-mediated-p38-mapk-and-pi3k-akt-mtor-signaling-pathways-in-skov-3-cells
#19
Wenjie Jiang, Yanna Cheng, Na Zhao, Lian Li, Yikang Shi, Aizhen Zong, Fengshan Wang
Previous studies demonstrated that SIP-SII, a sulfated derivative of SIP that is isolated from the ink of Sepiella maindroni, showed significant inhibition of tumor growth and metastasis. In this study, the effects of SIP-SII on the migration, invasion and molecular mechanism in ovarian cancer cell line, SKOV-3 cells, were investigated. The flow cytometry, confocal microscope observation, western blot and RT-PCR results indicated that SIP-SII located on cell membrane and inhibited the expression and activation of epidermal growth factor receptor (EGFR)...
September 1, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28866556/understanding-a-sequence-of-sequences-visual-exploration-of-categorical-states-in-lake-sediment-cores
#20
Andrea Unger, Nadine Drager, Mike Sips, Dirk J Lehmann
This design study focuses on the analysis of a time sequence of categorical sequences. Such data is relevant for the geoscientific research field of landscape and climate development. It results from microscopic analysis of lake sediment cores. The goal is to gain hypotheses about landscape evolution and climate conditions in the past. To this end, geoscientists identify which categorical sequences are similar in the sense that they indicate similar conditions. Categorical sequences are similar if they have similar meaning (semantic similarity) and appear in similar time periods (temporal similarity)...
August 30, 2017: IEEE Transactions on Visualization and Computer Graphics
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