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https://www.readbyqxmd.com/read/28208108/dietary-administration-of-edc-mixtures-a-focus-on-fish-lipid-metabolism
#1
O Carnevali, V Notarstefano, I Olivotto, M Graziano, P Gallo, I Di Marco Pisciottano, L Vaccari, A Mandich, E Giorgini, F Maradonna
Many man-made chemical compounds are recognized as endocrine disruptors and once released into the environment are likely to spread and bioaccumulate in wild species. Due to their lipophilic nature, these substances pass through the cell membrane or bind to specific receptors activating physiological responses that in the long run can cause reproductive impairment, physiological disorders, including the occurrence of metabolic syndromes. One significant source of contamination is represented by the consumption of polluted food...
February 6, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28195970/reduction-of-physiological-strain-under-a-hot-and-humid-environment-by-a-hybrid-cooling-vest
#2
Albert P C Chan, Y Yang, Francis K W Wong, Michael C H Yam, Del P Wong, W F Song
Cooling treatment is regarded as one of good practices to provide safe training conditions to athletic trainers in the hot environment. The present study aimed to investigate whether wearing a commercial lightweight and portable hybrid cooling vest that combines air ventilation fans with frozen gel packs was an effective means to reduce participants' body heat strain. In this within-subject repeated measures study, 10 male volunteers participated in two heat-stress trials (one with the cooling vest - COOL condition, and another without - CON condition, in a randomized order) inside a climatic chamber with a controlled ambient temperature 33 °C and relative humidity (RH) 75% on an experimental day...
February 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28193464/igas-a-framework-for-using-electronic-intraoperative-medical-records-for-genomic-discovery
#3
Matthew A Levin, Thomas T Joseph, Janina M Jeff, Rajiv Nadukuru, Stephen B Ellis, Erwin P Bottinger, Eimear E Kenny
OBJECTIVE: Design and implement a HIPAA and Integrating the Healthcare Enterprise (IHE) profile compliant automated pipeline, the integrated Genomics Anesthesia System (iGAS), linking genomic data from the Mount Sinai Health System (MSHS) BioMe biobank to electronic anesthesia records, including physiological data collected during the perioperative period. The resulting repository of multi-dimensional data can be used for precision medicine analysis of physiological readouts, acute medical conditions, and adverse events that can occur during surgery...
February 10, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28187188/development-of-a-flow-chamber-system-for-the-reproducible-in-vitro-analysis-of-biofilm-formation-on-implant-materials
#4
Henryke Rath, Sascha Nico Stumpp, Meike Stiesch
Since the introduction of modern dental implants in the 1980s, the number of inserted implants has steadily increased. Implant systems have become more sophisticated and have enormously enhanced patients' quality of life. Although there has been tremendous development in implant materials and clinical methods, bacterial infections are still one of the major causes of implant failure. These infections involve the formation of sessile microbial communities, called biofilms. Biofilms possess unique physical and biochemical properties and are hard to treat conventionally...
2017: PloS One
https://www.readbyqxmd.com/read/28183820/sarcolipin-expression-is-not-required-for-the-mitochondrial-enzymatic-response-to-physical-activity-or-diet
#5
Daniel Gamu, Anton Trinh, Val A Farjado, Eric Bombardier, A Russell Tupling
In mice, transgenic manipulation of Ca(2+)-handling proteins is sufficient to alter the metabolic phenotype of muscle. We have previously shown that ablation of sarcolipin (SLN), a regulatory protein and uncoupler of sarco(endo)plasmic reticulum Ca(2+)-ATPases, leads to excessive diet-induced obesity and glucose intolerance in mice. However, it is unclear how loss of SLN per se affects muscle oxidative capacity and the ability of mitochondria to adapt to physiological stimuli such as exercise training or calorie overload...
February 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28181236/ca-2-tunneling-through-the-er-lumen-as-a-mechanism-for-delivering-ca-2-entering-via-store-operated-ca-2-channels-to-specific-target-sites
#6
Ole H Petersen, Raphael Courjaret, Khaled Machaca
Ca(2+) signalling is perhaps the most universal and versatile mechanism regulating a wide range of cellular processes. Because of the many different calcium-binding proteins distributed throughout cells, signalling precision requires localized rises in the cytosolic Ca(2+) concentration. In electrically non-excitable cells, for example epithelial cells, this is achieved by primary release of Ca(2+) from the endoplasmic reticulum via Ca(2+) release channels placed close to the physiological target. Because any rise in the cytosolic Ca(2+) concentration activates Ca(2+) extrusion, and in order for cells not to run out of Ca(2+) , there is a need for compensatory Ca(2+) uptake from the extracellular fluid...
February 9, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28178926/framework-for-the-establishment-of-a-feasible-tailored-and-effective-perinatal-education-programme
#7
Isabel Artieta-Pinedo, Carmen Paz-Pascual, Gonzalo Grandes, Maite Espinosa
BACKGROUND: Antenatal education needs to be renewed and adapted to the needs of women. OBJECTIVES: to assess women needs, identify factors that influence the desired outcomes, and propose a framework for developing new perinatal education based on the guidance published by the UK Medical Research Council for the development and evaluation of complex interventions in primary care. METHODS: For this study: (a) four focus group sessions were held from October to November 2010 in Bizkaia (Spain) with 30 women exploring their needs during pregnancy and postpartum; (b) two literature reviews were conducted on women's needs at these times and theoretical models of healthcare education; and (c) seven discussion and consensus sessions were run with a group of experts composed of midwifes, gynaecologists, paediatricians, and paediatric and postpartum nurses...
February 8, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28177719/impact-of-polyphenols-on-physiological-stress-and-cardiac-burden-in-marathon-runners-results-from-a-substudy-of-the-bemagic-study
#8
Sebastian Clauss, Johannes Scherr, Alan Hanley, Jens Schneider, Ina Klier, Korbinian Lackermair, Eva Hoster, Michael Vogeser, David C Nieman, Martin Halle, Thomas Nickel
Introduction Both physiologic stress and chronic heart disease are associated with increased systemic levels of chromogranin A (CGA) and NT-proBNP. Marathon running causes physiological stress and imposes a significant cardiac burden. Polyphenol-rich Mediterranean and Asian diets have been demonstrated to exert beneficial effects on the cardiovascular system. In this study we investigated whether pretreatment with a polyphenol beverage could attenuate the physiological and cardiac stress associated with a marathon...
January 16, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28174540/the-influence-of-mid-event-deception-on-psychophysiological-status-and-pacing-can-persist-across-consecutive-disciplines-and-enhance-self-paced-multi-modal-endurance-performance
#9
Daniel Taylor, Mark F Smith
Purpose: To examine the effects of deceptively aggressive bike pacing on performance, pacing, and associated physiological and perceptual responses during simulated sprint-distance triathlon. Methods: Ten non-elite, competitive male triathletes completed three simulated sprint-distance triathlons (0.75 km swim, 500 kJ bike, 5 km run), the first of which established personal best "baseline" performance (BL). During the remaining two trials athletes maintained a cycling power output 5% greater than BL, before completing the run as quickly as possible...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28174099/combining-field-work-and-laboratory-work-in-the-study-of-financial-risk-taking
#10
REVIEW
John Coates, Mark Gurnell
A contribution to a special issue on Hormones and Human Competition. Financial markets are periodically destabilized by bubbles and crashes during which investors display respectively what has been called "irrational exuberance" and "irrational pessimism". How can we best study these pathologies in competitive and risk-taking behaviours? In this article, we argue that a science of risk-taking and of the financial markets needs to draw heavily on physiology and especially endocrinology, due to their central roles in moderating human behaviour...
February 4, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28167917/forced-running-endurance-is-influenced-by-gene-s-on-mouse-chromosome-10
#11
Mindaugas Kvedaras, Petras Minderis, Andrej Fokin, Aivaras Ratkevicius, Tomas Venckunas, Arimantas Lionikas
Phenotypic diversity between laboratory mouse strains provides a model for studying the underlying genetic mechanisms. The A/J strain performs poorly in various endurance exercise models. The aim of the study was to test if endurance capacity and contractility of the fast- and slow-twitch muscles are affected by the genes on mouse chromosome 10. The C57BL/6J (B6) strain and C57BL/6J-Chr 10(A/J)/NaJ (B6.A10) consomic strain which carries the A/J chromosome 10 on a B6 strain background were compared. The B6.A10 mice compared to B6 were larger in body weight (p < 0...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28167230/adaptation-to-a-blood-pressure-telemetry-system-revealed-by-measures-of-activity-agility-and-operant-learning-in-mice
#12
Anfisa Popova, Darya Tsvirkun, Oleg Dolgov, Konstantin Anokhin, Jeffrey Alberts, Evgeniia Lagereva, Marc-Antoine Custaud, Guillemette Gauquelin-Koch, Olga Vinogradova, Alexander Andreev-Andrievskiy
INTRODUCTION: Implantable telemetry enables continuous monitoring of physiological functions in freely moving animals and can greatly complement pharmacological research. Despite its miniaturization, a sensor/transmitter constitutes 5% or more of a mouse's bodyweight. The aim of the present study was to evaluate whether factors related to the presence of a probe/transmitter influence the ambulatory activity, strength, agility, or operant, motivated behaviors of this small rodent. METHODS: Adult male mice (C57BL/6N, 22-25g, 9-10weeks; implanted n=26, intact n=45) were evaluated during week-long tests, conducted three and eight weeks after surgical implantation of the PA-C10 blood pressure probe...
February 3, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28166612/acute-exercise-activates-p38-mapk-and-increases-the-expression-of-telomere-protective-genes-in-cardiac-muscle
#13
Andrew T Ludlow, Laila Gratidao, Lindsay W Ludlow, Espen E Spangenburg, Stephen M Roth
Age is the greatest risk factor for cardiovascular disease. Telomere length is shorter in the hearts of aged mice compared to young mice, and short telomere length has been associated with an increased risk of cardiovascular disease. One year of voluntary wheel running exercise attenuates the age-associated loss of telomere length and results in altered gene expression of telomere length maintaining and genome stabilizing proteins in heart tissue of mice. Understanding the early adaptive response of the heart to an endurance exercise bout is paramount to understanding the impact of endurance exercise on heart tissue and cells...
February 6, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28164383/physiological-biochemical-anthropometric-and-biomechanical-influences-on-exercise-economy-in-humans
#14
Carsten Lundby, David Montero, Saskia Gehrig, Ulrika Anderson Hall, Pascal Kaiser, Robert Boushel, Anne-Kristine Meinild Lundby, Niels Kirk, Paola Valdivieso, Martin Flück, Niels H Secher, Frederik Edin, Tobias Hein, Klavs Madsen
Inter-individual variation in running and cycling exercise economy (EE) remains unexplained although studied for more than a century. This study is the first to comprehensively evaluate the importance of biochemical, structural, physiological, anthropometric, and biomechanical influences on running and cycling EE within a single study. In 22 healthy males (VO2 max range 45.5 to 72.1 ml.min(-1) .kg(-1) ) no factor related to skeletal muscle structure (% slow twitch fibre content, number of capillaries per fibre), mitochondrial properties (volume density, oxidative capacity, or mitochondrial efficiency) or protein content (UCP3 and MFN2 expression) explained variation in cycling and running EE among subjects...
February 5, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28163143/on-the-detection-of-high-frequency-correlations-in-resting-state-fmri
#15
Cameron Trapp, Kishore Vakamudi, Stefan Posse
Current studies of resting-state connectivity rely on coherent signal fluctuations at frequencies below 0.1 Hz, however, recent studies using high-speed fMRI have shown that fluctuations above 0.5 Hz may exist. This study replicates the feasibility of measuring high frequency (HF) correlations in six healthy controls and a patient with a brain tumor while analyzing non-physiological signal sources via simulation. Resting-state data were acquired using a high-speed multi-slab echo-volumar imaging pulse sequence with 136 ms temporal resolution...
February 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28158252/physiological-responses-and-external-validity-of-a-new-setting-for-taekwondo-combat-simulation
#16
Matheus Hausen, Pedro Paulo Soares, Marcus Paulo Araújo, Flávia Porto, Emerson Franchini, Craig Alan Bridge, Jonas Gurgel
Combat simulations have served as an alternative framework to study the cardiorespiratory demands of the activity in combat sports, but this setting imposes rule-restrictions that may compromise the competitiveness of the bouts. The aim of this study was to assess the cardiorespiratory responses to a full-contact taekwondo combat simulation using a safe and externally valid competitive setting. Twelve male national level taekwondo athletes visited the laboratory on two separate occasions. On the first visit, anthropometric and running cardiopulmonary exercise assessments were performed...
2017: PloS One
https://www.readbyqxmd.com/read/28155605/met-activating-genetically-improved-chimeric-factor-1-promotes-angiogenesis-and-hypertrophy-in-adult-myogenesis
#17
Flavio Ronzoni, Gabriele Ceccarelli, Ilaria Perini, Laura Benedetti, Daniela Galli, Francesca Mulas, Martina Balli, Giovanni Magenes, Riccardo Bellazzi, Gabriella Cusella De Angelis, Maurilio Sampaolesi
BACKGROUND: Myogenic progenitor cells (activated satellite cells) are able to express both HGF and its receptor cMet. After muscle injury, HGF-Met stimulation promotes activation and primary division of satellite cells. MAGIC-F1 (Met-Activating Genetically Improved Chimeric Factor-1) is an engineered protein that contains two human Met-binding domains that promotes muscle hypertrophy. MAGIC-F1 protects myogenic precursors against apoptosis and increases their fusion ability enhancing muscle differentiation...
February 1, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28149367/triathlon-wetsuit-removal-strategy-physiological-cost-of-running-with-a-wetsuit
#18
Mihaela Ciulei, Aaron Prado, James Navalta, John A Mercer
Triathletes exiting the swim portion of an event have to decide on how and when to take a wetsuit off (if worn). The purpose of this study was to determine the physiological cost of running while not using a wetsuit, carrying a wetsuit, wearing a wetsuit halfway down or wearing a wetsuit fully up. Participants (n = 20, 30.9 ± 8.7 yrs, 1.71 ± 0.08 m, 71.6 ± 9.5 kg) completed four 5 min running conditions: 1) not wearing the wetsuit, 2) wearing the wetsuit fully up, 3) wearing the wetsuit halfway down, and 4) carrying the wetsuit...
June 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28149347/application-of-a-physiological-strain-index-in-evaluating-responses-to-exercise-stress-a-comparison-between-endurance-and-high-intensity-intermittent-trained-athletes
#19
Ilona Pokora, Aleksandra Żebrowska
The study evaluated differences in response to exercise stress between endurance and high-intensity intermittent trained athletes in a thermoneutral environment using a physiological strain index (PSI). Thirty-two subjects participated in a running exercise under normal (23°C, 50% RH) conditions. The group included nine endurance trained athletes (middle-distance runners - MD), twelve high-intensity intermittent trained athletes (soccer players - HIIT) and eleven students who constituted a control group. The exercise started at a speed of 4 km·h(-1) which was increased every 3 min by 2 km·h(-1) to volitional exhaustion...
April 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28146032/different-training-loads-partially-influence-physiological-responses-to-preparation-period-in-basketball
#20
Davide Ferioli, Andrea Bosio, Antonio La Torre, Domenico Carlomagno, Darragh R Connolly, Ermanno Rampinini
The aim of this study was to compare perceived TL (sRPE-TL), training volume (TV) and the changes in physical fitness between professional (n=14) and semi-professional (n=18) basketball players during the preparation period. Furthermore, relationships between sRPE-TL and TV with changes in physical fitness level were investigated. The players performed the Yo-Yo Intermittent Recovery Test (Yo-Yo IR1) before and after the preparation period. In addition, physiological responses to a standardized 6-min continuous running test (Mognoni's test) and to a standardized 5-min high-intensity intermittent running test (HIT) were measured...
January 30, 2017: Journal of Strength and Conditioning Research
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