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https://www.readbyqxmd.com/read/28932899/voluntary-running-enhanced-synaptic-plasticity-learning-and-memory-are-mediated-by-notch1-signal-pathway-in-c57bl-mice
#1
Xiaochen Zhang, Chunxiao Yang, Jing Gao, Hongqiang Yin, Hui Zhang, Tao Zhang, Zhuo Yang
It is well known that voluntary running can enhance synaptic plasticity and improve learning and memory abilities. The Notch1 receptor is also reported to be associated with these processes, but its role in running-induced alterations is unclear. In this study, we aimed to investigate whether the Notch1 signalling pathway was involved in voluntary running-induced enhancement of synaptic plasticity, learning and memory. Notch1 heterozygous deficient (Notch1(+/-)) mice and wildtype (WT) C57BL littermates were randomly divided into runner group and non-runner group...
September 20, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28916706/the-expression-of-ldh-c-in-the-skeletal-muscle-of-plateau-pika-ochotona-curzoniae-enhances-adaptation-to-a-hypoxic-environment
#2
Zhi F An, Deng B Wei, Lian Wei, Yang Wang, Lin N Wei
The plateau pika (Ochotona curzoniae) is a species of sprint-running alpine animals in the Qinghai-Tibet Plateau, which is a harsh highland hypoxic environment. Ldh-c is expressed in the testis, sperm and somatic tissues of plateau pika. To reveal the role and physiological mechanisms of sperm-specific lactate dehydrogenase (LDH-C4), in plateau pika to adapt to hypoxic environment, an adenoviral line of pMultiRNAi-Ldhc was constructed and injected into the bilateral biceps femoris of the hind legs. The swimming times of the pikas, and the Ldh-c expression levels, total LDH activities and ATP levels in skeletal muscle, were measured after the pikas were raised in the trapped site for 5 days...
September 15, 2017: Biology Open
https://www.readbyqxmd.com/read/28912649/does-live-high-train-low-and-high-hypoxic-training-alter-running-mechanics-in-elite-team-sport-players
#3
Olivier Girard, Grégoire P Millet, Jean-Benoit Morin, Franck Brocherie
This study aimed to investigate if "Live High-Train Low (and High)" hypoxic training alters constant-velocity running mechanics. While residing under normobaric hypoxia (≥14 h·d(-1); FiO2 14.5-14.2%) for 14 days, twenty field hockey players performed, in addition to their usual training in normoxia, six sessions (4 × 5 × 5-s maximal sprints; 25 s passive recovery; 5 min rest) under either normobaric hypoxia (FiO2 ~14.5%, n = 9) or normoxia (FiO2 20.9%, n = 11). Before and immediately after the intervention, their running pattern was assessed at 10 and 15 km·h(-1) as well as during six 30-s runs at ~20 km·h(-1) with 30-s passive recovery on an instrumented motorised treadmill...
September 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28912088/sip-and-spit-or-sip-and-swallow-choice-of-method-differentially-alters-taste-intensity-estimates-across-stimuli
#4
Cordelia A Running, John E Hayes
While the myth of the tongue map has been consistently and repeatedly debunked in controlled studies, evidence for regional differences in suprathreshold intensity has been noted by multiple research groups. Given differences in physiology between the anterior and posterior tongue (fungiform versus foliate and circumvallate papillae) and differences in total area stimulated (anterior only versus whole tongue, pharynx, and epiglottis), small methodological changes (sip and spit versus sip and swallow) have the potential to substantially influence data...
September 11, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28902113/comparative-effects-of-two-interval-shuttle-run-training-modes-on-physiological-and-performance-adaptations-in-female-professional-futsal-players
#5
Anderson S Teixeira, Francimara B Arins, Ricardo D De Lucas, Lorival J Carminatti, Naiandra Dittrich, Fábio Yuzo Nakamura, Luiz Guilherme A Guglielmo
The purpose of the present study was to analyze the effects of two shuttle-run interval training (SRIT) models with one and three directional changes per running bout on the aerobic and anaerobic performances of elite female futsal players. Sixteen players competing in the Brazilian National Division League took part in the study. The training protocols consisted of shuttle-run intervals organized in four sets of 4-min bouts with 3- min of rest intervals between the sets. The SRIT models were composed of one (7...
September 6, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28901173/cyclin-d2-is-a-critical-mediator-of-exercise-induced-cardiac-hypertrophy
#6
Stephen W Luckey, Chris D Haines, John P Konhilas, Elizabeth D Luczak, Antke Messmer-Kratzsch, Leslie A Leinwand
A number of signaling pathways underlying pathological cardiac hypertrophy have been identified. However, few studies have probed the functional significance of these signaling pathways in the context of exercise or physiological pathways. Exercise studies were performed on females from six different genetic mouse models that have been shown to exhibit alterations in pathological cardiac adaptation and hypertrophy. These include mice expressing constitutively active glycogen synthase kinase-3β (GSK-3βS9A), an inhibitor of CaMK II (AC3-I), both GSK-3βS9A and AC3-I (GSK-3βS9A/AC3-I), constitutively active Akt (myrAkt), mice deficient in MAPK/ERK kinase kinase-1 (MEKK1(-/-)), and mice deficient in cyclin D2 (cyclin D2(-/-))...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28899656/greater-ankle-strength-anaerobic-and-aerobic-capacity-and-agility-predict-ground-combat-military-occupational-school-graduation-in-female-marines
#7
Katelyn Fleishman Allison, Karen A Keenan, Meleesa F Wohleber, Katherine A Perlsweig, Erin R Pletcher, Mita Lovalekar, Kim Beals, Lawrence C Coleman, Bradley C Nindl
Women can serve in all military occupational specialties (MOS); however, musculoskeletal and physiological characteristics that predict successful completion of ground combat MOS schools by female Marines are unknown. OBJECTIVES: To determine which demographic, musculoskeletal, and physiological characteristics predict graduation from infantry and vehicle ground combat MOS schools in female Marines. DESIGN: Prospective cohort study. METHODS: Prior to MOS school, the following were assessed in 62 female Marines (22...
August 24, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28899425/the-physiological-determinants-of-low-level-urine-cadmium-an-assessment-in-a-cross-sectional-study-among-schoolchildren
#8
Hongyu Wang, Xavier Dumont, Vincent Haufroid, Alfred Bernard
BACKGROUND: Recent studies in children have reported associations of urinary cadmium (U-Cd), used as biomarker of Cd body burden, with renal dysfunction, retarded growth and impaired cognitive development in children. Little is known, however, about factors influencing U-Cd in children and likely to act as confounders. METHODS: In a cross-sectional study involving 249 schoolchildren (mean age, 5.72 years; 138 boys), we measured the urine concentrations of cadmium, zinc, lead, albumin, alpha1-microglobulin (A1M), retinol-binding protein, β2-microglobulin and club cell protein (CC16)...
September 12, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28889219/a-validated-uplc-ms-ms-method-coupled-with-protein-precipitation-and-ion-exchange-solid-phase-extraction-for-the-quantitation-of-porcine-relaxin-b29-in-dog-plasma-and-its-application-to-a-pharmacokinetic-study
#9
Chong Su, Hui Sun, Hong Yang, Lei Yin, Jiwen Zhang, John Paul Fawcett, Jingkai Gu
Porcine relaxin is a 6 kDa peptide hormone of pregnancy with important physiological and pharmacological effects. It contains a number of analogs of which porcine relaxin B29 is one of the most important. To support the development of porcine relaxin B29 as a new drug, we established an UPLC-MS/MS method for its quantitation in dog plasma. Sample preparation by protein precipitation and ion exchange solid phase extraction was followed by UPLC on an XBridge™ BEH300 C18 column at 40 °C in a run time of only 5...
September 9, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28885961/effectiveness-of-ice-sheet-cooling-following-exertional-hyperthermia
#10
Cory L Butts, Debora L Spisla, J D Adams, Cody R Smith, Kathleen M Paulsen, Aaron R Caldwell, Matthew S Ganio, Brendon P McDermott
BACKGROUND: The procedure of wrapping a heat casualty in ice-water soaked bed sheets to reduce core temperature has received little investigation, despite the practice and recommendation for its use in some military settings. Thus, the purpose of this study was to investigate the cooling efficacy of ice-sheet cooling (ISC) following exertional hyperthermia. METHODS: 13 (11 males, 2 females) participants (age = 23 ± 3 years, height = 176.5 ± 10.3 cm, mass = 78...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28883785/early-postnatal-but-not-late-adult-neurogenesis-is-impaired-in-the-pitx3-mutant-animal-model-of-parkinson-s-disease
#11
Moritz D Brandt, Diana Krüger-Gerlach, Andreas Hermann, Anne K Meyer, Kwang-Soo Kim, Alexander Storch
The generation of new neurons in the adult dentate gyrus has functional implications for hippocampal formation. Reduced hippocampal neurogenesis has been described in various animal models of hippocampal dysfunction such as dementia and depression, which are both common non-motor-symptoms of Parkinson's disease (PD). As dopamine plays an important role in regulating precursor cell proliferation, the loss of dopaminergic neurons in the substantia nigra (SN) in PD may be related to the reduced neurogenesis observed in the neurogenic regions of the adult brain: subventricular zone (SVZ) and dentate gyrus (DG)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28880924/localization-of-photo-respiration-and-co2-re-assimilation-in-tomato-leaves-investigated-with-a-reaction-diffusion-model
#12
Herman N C Berghuijs, Xinyou Yin, Q Tri Ho, Moges A Retta, Pieter Verboven, Bart M Nicolaï, Paul C Struik
The rate of photosynthesis depends on the CO2 partial pressure near Rubisco, Cc, which is commonly calculated by models using the overall mesophyll resistance. Such models do not explain the difference between the CO2 level in the intercellular air space and Cc mechanistically. This problem can be overcome by reaction-diffusion models for CO2 transport, production and fixation in leaves. However, most reaction-diffusion models are complex and unattractive for procedures that require a large number of runs, like parameter optimisation...
2017: PloS One
https://www.readbyqxmd.com/read/28880549/binding-and-release-between-polymeric-carrier-and-protein-drug-ph-mediated-interplay-of-coulomb-forces-hydrogen-bonding-van-der-waals-interactions-and-entropy
#13
Sergio De Luca, Fan Chen, Prasenjit Seal, Martina H Stenzel, Sean C Smith
The accelerating search for new types of drugs and delivery strategies poses the challenge to understand the mechanism of delivery. To this end, a detailed atomistic picture of binding between the drug and the carrier is quintessential. While many studies focus on the electrostatics of drug-vector interactions, it has also been pointed out that entropic factors relating to water and counter ions can play an important role. By carrying out extensive molecular dynamics simulations and subsequently validating with experiment, we shed light herein on the binding in aqueous solution between a protein drug and a polymeric carrier...
September 7, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28880151/salivary-markers-for-quantitative-dehydration-estimation-during-physical-exercise
#14
Matthias Ring, Clemens Lohmueller, Manfred Rauh, Joachim Mester, Bjoern M Eskofier
Salivary markers have been proposed as noninvasive and easy-to-collect indicators of dehydrations during physical exercise. It has been demonstrated that threshold-based classifications can distinguish dehydrated from euhydrated subjects. However, considerable challenges were reported simultaneously, for example, high intersubject variabilities in these markers. Therefore, we propose a machine-learning approach to handle the intersubject variabilities and to advance from binary classifications to quantitative estimations of total body water (TBW) loss...
September 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28877266/feasibility-of-using-a-hand-held-device-to-characterize-tendon-tissue-biomechanics
#15
Sahand Sohirad, David Wilson, Charlotte Waugh, Evan Finnamore, Alexander Scott
OBJECTIVES: To examine the feasibility of using the MyotonPRO digital palpation device in measuring the transverse stiffness of tendon tissue. DESIGN: Experimental study. METHODS: The MyotonPRO was used to measure the stiffness and related properties of ballistics gel in comparison with an external materials testing system (PCB electronics). The device was then used to measure the same properties of avian Achilles tendons before and after the removal of the overlying skin and subcutaneous tissue...
2017: PloS One
https://www.readbyqxmd.com/read/28869746/physiological-intensity-profile-exercise-load-and-performance-predictors-of-a-65-km-mountain-ultra-marathon
#16
Alessandro Fornasiero, Aldo Savoldelli, Damiano Fruet, Gennaro Boccia, Barbara Pellegrini, Federico Schena
The aims of the study were to describe the physiological profile of a 65-km (4000-m cumulative elevation gain) running mountain ultra-marathon (MUM) and to identify predictors of MUM performance. Twenty-three amateur trail-runners performed anthropometric evaluations and an uphill graded exercise test (GXT) for VO2max, ventilatory thresholds (VTs), power outputs (PMax, PVTs) and heart rate response (HRmax, HR@VTs). Heart rate (HR) was monitored during the race and intensity was expressed as: Zone I (<VT1), Zone II (VT1-VT2), Zone III (>VT2) for exercise load calculation (training impulse, TRIMP)...
September 4, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28865018/making-of-a-synapse-recurrent-roles-of-drebrin-a-at-excitatory-synapses-throughout-life
#17
Chiye Aoki, Ang D Sherpa
Mature excitatory synapses are composed of more than 1500 proteins postsynaptically and hundreds more that operate presynaptically. Among them, drebrin is an F-actin-binding protein that increases noticeably during juvenile synaptogenesis. Electron microscopic analysis reveals that drebrin is highly enriched specifically on the postsynaptic side of excitatory synapses. Since dendritic spines are structures specialized for excitatory synaptic transmission, the function of drebrin was probed by analyzing the ultrastructural characteristics of dendritic spines of animals with genetic deletion of drebrin A (DAKO), the adult isoform of drebrin...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28860998/human-biomechanical-and-cardiopulmonary-responses-to-partial-gravity-a-systematic-review
#18
REVIEW
Charlotte Richter, Bjoern Braunstein, Andrew Winnard, Mona Nasser, Tobias Weber
The European Space Agency has recently announced to progress from low Earth orbit missions on the International Space Station to other mission scenarios such as exploration of the Moon or Mars. Therefore, the Moon is considered to be the next likely target for European human space explorations. Compared to microgravity (μg), only very little is known about the physiological effects of exposure to partial gravity (μg < partial gravity <1 g). However, previous research studies and experiences made during the Apollo missions comprise a valuable source of information that should be taken into account when planning human space explorations to reduced gravity environments...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28859831/automatic-reconstruction-of-the-muscle-architecture-from-the-superficial-layer-fibres-data
#19
Josef Kohout, David Cholt
BACKGROUND AND OBJECTIVE: Physiological cross-sectional area (PCSA) of a muscle plays a significant role in determining the force contribution of muscle fascicles to skeletal movement. This parameter is typically calculated from the lengths of muscle fibres selectively sampled from the superficial layer of the muscle. However, recent studies have found that the length of fibres in the superficial layer often differs significantly (p < 0.5) from the length of fibres in the deep layer...
October 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28859414/physiological-and-biomechanical-mechanisms-of-distance-specific-human-running-performance
#20
M A Thompson
Running events range from 60-m sprints to ultra-marathons covering 100 miles or more, which presents an interesting diversity in terms of the parameters for successful performance. Here, we review the physiological and biomechanical variations underlying elite human running performance in sprint to ultramarathon distances. Maximal running speeds observed in sprint disciplines are achieved by high vertical ground reaction forces applied over short contact times. To create this high force output, sprint events rely heavily on anaerobic metabolism, as well as a high number and large cross-sectional area of type II fibers in the leg muscles...
August 1, 2017: Integrative and Comparative Biology
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