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Ramón N Herrera, Julio A Miotti, Aldo S Pereyra, María V Lobo, Mariela T Ibarra, Andrés F Tomé Guzmán
Marfan syndrome is an infrequent genetic disorder of connective tissue whose clinical manifestations mainly affect the cardiovascular, ocular and musculoskeletal systems. Serious cardiovascular manifestations are generally the cause of mortality of Marfan patients. Thromboembolic venous disease is intimately related to different risk factors: inherited, acquired, mixed or unknown; hyperhomocysteinemia is a moderate risk factor for venous thromboembolism. We present the case of a 47-year-old woman with Marfan syndrome associated to a painless type A aortic dissection, who simultaneously suffered venous thromboembolism of left upper and lower limbs with pulmonary embolism...
2012: Medicina
Mario Terra-Filho, Marcos Figueiredo Mello, Mônica Silveira Lapa, Ricardo Henrique Oliveira Braga Teixeira, Fábio Biscegli Jatene
INTRODUCTION: Chronic thromboembolic pulmonary hypertension is a disease affecting approximately 4,000 people per year in the United States. The incidence rate in Brazil, however, is unknown. The estimated survival for patients with chronic thromboembolic pulmonary hypertension without treatment is approximately three years. Pulmonary thromboendarterectomy for select patients is a potentially curative procedure when correctly applied. In Brazil, the clinical and hemodynamic profiles of chronic thromboembolic pulmonary hypertension patients have yet to be described...
2010: Clinics
Ekaterina Uchikova, Blagovest Pehlivanov
OBJECTIVE: To compare the effects of two monophasic oral contraceptives upon coagulation, fibrinolysis and the system of natural inhibitors (anticoagulant pathways) in Bulgarian women. METHODS: This prospective, open clinical study lasted 12 months and included 70 women, divided into two equal groups of 35 each. The women from group A received a contraceptive containing 20 microg ethinylestradiol/75 microg gestodene. The women from group B received a contraceptive containing 30 microg ethinylestradio l/75 microg gestodene...
August 2008: Expert Opinion on Pharmacotherapy
I N Bokarev, A V Arshinov, A L Mel'nikov
The article describes the historical aspects of the formation of the notion antiphospholipid syndrome (AFS) as well as the development of the conception of its clinical symptoms and laboratory tests confirming the diagnosis. Special attention is paid to the modern interpretation of the notion of AFS, which excludes a number of clinical symptoms and laboratory tests and defines more clearly the use of the rest of clinical and laboratory signs. Theoretical concepts of the pathogenetic mechanisms of the development of this disease and its association with congenital thrombofilias are adduced...
2007: Klinicheskaia Meditsina
Muge Aksoy, Ibrahim Tek, Halil Karabulut, Bulent Berker, Feride Soylemez
OBJECTIVE: To study, the impact of thrombophilia caused by Factor V, Factor ll G20210A mutations on recurrent abortions, the prevelance of Factor V Leiden and Factor II G20210A mutation in patients with habitual abortions. METHODS: Forty one patients with a diagnosis of habitual abortion were enrolled in the study. Control group consisted of 50 women without a history of poor obstetric outcome. 10 ml. peripheral venous blood was taken from study and control groups and transferred to EDTA tubes, and were tested for Factor V Leiden and Factor II G20210A mutations by PCR in genetics laboratory...
March 2005: JPMA. the Journal of the Pakistan Medical Association
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