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https://www.readbyqxmd.com/read/28213925/rotator-cuff-disease-opinion-regarding-surgical-criteria-and-likely-outcome
#1
Alison Thorpe, Mark Hurworth, Peter O'Sullivan, Tim Mitchell, Anne Smith
BACKGROUND: Clinical guidelines for the management of rotator cuff disease are not clear. Surgeon surveys in the USA and UK lack agreement regarding surgical indications. Physical examination tests aid surgical decision-making but also lack robust evidence. Study aims were to evaluate: Western Australian orthopaedic surgeons' perceptions about surgical indications; utility of physical examination tests; findings at surgery predictive of outcome and surgeon opinion of a successful surgical outcome...
February 17, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28213156/myotonic-dystrophy-disease-repeat-range-penetrance-age-of-onset-and-relationship-between-repeat-size-and-phenotypes
#2
REVIEW
Kevin Yum, Eric T Wang, Auinash Kalsotra
Myotonic dystrophy (DM) is an autosomal dominant neuromuscular disease primarily characterized by myotonia and progressive muscle weakness. The pathogenesis of DM involves microsatellite expansions in noncoding regions of transcripts that result in toxic RNA gain-of-function. Each successive generation of DM families carries larger repeat expansions, leading to an earlier age of onset with increasing disease severity. At present, diagnosis of DM is challenging and requires special genetic testing to account for somatic mosaicism and meiotic instability...
February 14, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/28211187/deletion-of-junctional-adhesion-molecule-a-from-platelets-increases-early-stage-neointima-formation-after-wire-injury-in-hyperlipidemic-mice
#3
Zhen Zhao, Tanja Vajen, Ela Karshovska, Annemiek Dickhout, Martin M Schmitt, Remco T A Megens, Philipp von Hundelshausen, Thomas A Koeppel, Tilman M Hackeng, Christian Weber, Rory R Koenen
Platelets play an important role in the pathogenesis of vascular remodelling after injury. Junctional adhesion molecule A (JAM-A) was recently described to regulate platelet activation. Specific deletion of JAM-A from platelets resulted in increased reactivity and in accelerated progression of atherosclerosis. The aim of this study was to investigate the specific contribution of platelet-derived JAM-A to neointima formation after vascular injury. Mice with or without platelet-specific (tr)JAM-A-deficiency in an apolipoprotein e (apoe(-/-) ) background underwent wire-induced injury of the common carotid artery...
February 17, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28209743/skeletal-muscle-bioenergetics-during-all-out-exercise-mechanistic-insight-into-the-oxygen-uptake-slow-component-and-neuromuscular-fatigue
#4
Ryan M Broxterman, Gwenael Layec, Thomas J Hureau, Markus Amann, Russell S Richardson
Although commonly used, the physiological mechanisms underlying all-out exercise performance are still unclear and an in-depth assessment of skeletal muscle bioenergetics is lacking. Therefore, phosphorous magnetic resonance spectroscopy ((31)P-MRS) was utilized to assess skeletal muscle bioenergetics during a 5-min all-out intermittent isometric knee-extensor protocol in 8 healthy men. The metabolic perturbation, adenosine triphosphate (ATP) synthesis rates, ATP cost of contraction, and mitochondrial capacity were determined from intramuscular concentrations of phosphocreatine (PCr), inorganic phosphate (Pi), diprotonated phosphate (H2PO4⁻ ), and pH...
February 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28197275/cardiac-resynchronization-therapy-leads-to-improvements-in-handgrip-strength
#5
David R Warriner, Patricia Lawford, Paul J Sheridan
BACKGROUND: A reduction in skeletal muscle performance measured by handgrip strength is common in heart failure. No trial has investigated the role of cardiac resynchronization therapy, which leads to improvements in cardiac performance, on the function of skeletal muscle in patients with heart failure. METHODS: Nineteen patients were recruited, 18 male, age 69 ± 8 years, New York Heart Association class II-IV, QRS duration 173 ± 21 ms and left ventricular ejection fraction 26±8%...
June 2016: Cardiology Research
https://www.readbyqxmd.com/read/28193157/whole-genome-association-analysis-of-pork-meat-ph-revealed-three-significant-regions-and-several-potential-genes-in-finnish-yorkshire-pigs
#6
Lucas L Verardo, Marja-Liisa Sevón-Aimonen, Timo Serenius, Ville Hietakangas, Pekka Uimari
BACKGROUND: One of the most commonly used quality measurements of pork is pH measured 24 h after slaughter. The most probable mode of inheritance for this trait is oligogenic with several known major genes, such as PRKAG3. In this study, we used whole-genome SNP genotypes of over 700 AI boars; after a quality check, 42,385 SNPs remained for association analysis. All the boars were purebred Finnish Yorkshire. To account for relatedness of the animals, a pedigree-based relationship matrix was used in a mixed linear model to test the effect of SNPs on pH measured from loin...
February 13, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28191601/the-maxillary-artery-and-its-variants-an-anatomical-study-with-neurosurgical-applications
#7
Jorge E Alvernia, Joaquin Hidalgo, Marc P Sindou, Chad Washington, Gustavo Luzardo, Eddie Perkins, Remi Nader, Patrick Mertens
BACKGROUND: The maxillary artery (MA) has gained attention in neurosurgery particularly in cerebral revascularization techniques, intracranial endonasal approaches and endovascular procedures. OBJECTIVES: To describe and illustrate the anatomy of the MA and its neurosurgical importance in a detailed manner. METHODS: Six cadaveric heads (12 MAs) were injected with latex. The arteries and surrounding structures were dissected and studied using microsurgical techniques...
February 13, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28185377/feeding-corn-distillers-grains-as-an-energy-source-to-gestating-and-lactating-beef-heifers-impact-of-excess-protein-on-feedlot-performance-glucose-tolerance-carcass-characteristics-and-longissimus-muscle-fatty-acid-profile-of-steer-progeny
#8
Patrick J Gunn, Glen A Bridges, Ronald P Lemenager, Jon P Schoonmaker
This study was conducted to determine the impact of dried distiller's grain with solubles (DDGS) from 192 days of gestation through 118 days of lactation on feedlot performance, carcass characteristics, Longissimus muscle (LM) fatty acids and glucose tolerance of male progeny (n = 36). Angus-Simmental heifer dams were fed diets that contained either DDGS (DG) or not (CON) formulated to provide similar daily net energy for gain but differing crude protein. In the feedlot, male progeny were fed a diet devoid of DDGS...
February 9, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28183169/effects-of-wheat-supplementation-levels-on-growth-performance-blood-profiles-nutrient-digestibility-and-pork-quality-in-growing-finishing-pigs
#9
Taehee Han, J S Hong, L H Fang, S H Do, B O Kim, Y Y Kim
Objective: This study was conducted to evaluate various wheat supplementation levels on growth performance, blood profiles, nutrient digestibility, and pork quality in growing-finishing pigs. Methods: A total of 120 growing pigs ([Yorkshire × Landrace] × Duroc), with an average 27.75 ± 1.319 kg body weight (BW), were used in growth trial. Pigs were allotted into each treatment by body weight and sex in 4 replicates with 6 pigs per pen in a randomized complete block (RCB) design...
February 1, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28182001/rasal2-a-ras-gtpase-activating-protein-inhibits-stemness-and-epithelial-mesenchymal-transition-via-mapk-sox2-pathway-in-bladder-cancer
#10
Ke Hui, Yang Gao, Jun Huang, Shan Xu, Bin Wang, Jin Zeng, Jinhai Fan, Xinyang Wang, Yangyang Yue, Shiqi Wu, Jer-Tsong Hsieh, Dalin He, Kaijie Wu
Muscle-invasive or metastatic bladder cancer (BCa) is associated with a very poor prognosis, and the underlying mechanism remains poorly understood. In this study, we demonstrate RASAL2, a RAS GTPase-activating protein (RAS GAP), acts as a tumor suppressor in BCa. First, RASAL2 was downregulated in BCa specimens and inversely correlated with pathological grades and clinical stages. Furthermore, we observed that RASAL2 could inhibit BCa stemness and epithelial-mesenchymal transition (EMT) based on our gain-of-function and loss-of-function experiments...
February 9, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28175977/development-and-evaluation-of-a-novel-curved-biopsy-device-for-ct-guided-biopsy-of-lesions-unreachable-using-standard-straight-needle-trajectories
#11
Maximilian Franz Schulze-Hagen, Jochen Pfeffer, Markus Zimmermann, Martin Liebl, Saskia Freifrau von Stillfried, Christiane Kuhl, Philipp Bruners, Peter Isfort
PURPOSE: To evaluate the feasibility of a novel curved CT-guided biopsy needle prototype with shape memory to access otherwise not accessible biopsy targets. METHODS AND MATERIALS: A biopsy needle curved by 90° with specific radius was designed. It was manufactured using nitinol to acquire shape memory, encased in a straight guiding trocar to be driven out for access of otherwise inaccessible targets. Fifty CT-guided punctures were conducted in a biopsy phantom and 10 CT-guided punctures in a swine corpse...
February 7, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28167333/regional-asymmetry-of-metabolic-and-antioxidant-profile-in-the-sciaenid-fish-shi-drum-umbrina-cirrosa-white-muscle-response-to-starvation-and-refeeding
#12
M Carmen Hidalgo, Amalia E Morales, Marta Arizcun, Emilia Abellán, Gabriel Cardenete
The objective of the present study is to characterize the metabolic and antioxidant profile of white muscle of shi drum in two sites of the body, anterior dorsal (AM) and posterior dorsal (PM) portions. In addition, it will be analyzed the possible effect of starvation and a subsequent refeeding, with two different protocols, pair feeding and ad libitum. Activities of key enzymes of intermediary metabolism and of antioxidant enzymes, as well as lipid peroxidation, as an index of oxidative stress, were evaluated...
February 1, 2017: Redox Biology
https://www.readbyqxmd.com/read/28166765/optitrain-a-randomised-controlled-exercise-trial-for-women-with-breast-cancer-undergoing-chemotherapy
#13
Y Wengström, K A Bolam, S Mijwel, C J Sundberg, M Backman, M Browall, J Norrbom, H Rundqvist
BACKGROUND: Women with breast cancer undergoing chemotherapy suffer from a range of detrimental disease and treatment related side-effects. Exercise has shown to be able to counter some of these side-effects and improve physical function as well as quality of life. The primary aim of the study is to investigate and compare the effects of two different exercise regimens on the primary outcome cancer-related fatigue and the secondary outcomes muscle strength, function and structure, cardiovascular fitness, systemic inflammation, skeletal muscle gene activity, health related quality of life, pain, disease and treatment-related symptoms in women with breast cancer receiving chemotherapy...
February 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28164048/rare-giant-cell-tumor-of-olecranon-bone
#14
Pawan Goyal, Vishal Gautam, Narender Saini, Yogesh Sharma
INTRODUCTION: Giant cell tumor (GCT) is a bone tumor involving epiphyseal area of bone abutting the subchondral bone. Commonly found in long bones such as proximal tibia and distal femur. We report a case of GCT of olecranon bone in a 23-year-old male. CASE REPORT: A 23-year-old patient presented to our outpatient department with pain and mild swelling at the elbow from last 2 to 3 months. On examination, it was seen that there was a moderate swelling at the tip of the olecranon...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28160750/repetitive-peripheral-magnetic-neurostimulation-of-multifidus-muscles-combined-with-motor-training-influences-spine-motor-control-and-chronic-low-back-pain
#15
Hugo Massé-Alarie, Louis-David Beaulieu, Richard Preuss, Cyril Schneider
OBJECTIVE: The study tested whether combining repetitive peripheral magnetic stimulation (RPMS) and motor training of the superficial multifidus muscle (MF) better improved the corticomotor control of spine than training alone in chronic low back pain (CLBP). METHODS: Twenty-one participants with CLBP were randomly allocated to [RPMS+training] and [Sham+training] groups for three sessions (S1-S3) over a week where MF was stimulated before training (volitional contraction)...
March 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28160082/periodization-effects-during-short-term-resistance-training-with-equated-exercise-variables-in-females
#16
Thiemo Pelzer, Boris Ullrich, Mark Pfeiffer
PURPOSE: During resistance training, volume and load can be altered either gradually (traditional periodization: TP) or with frequent changes between subsequent sessions (daily undulating periodization: DUP). We hypothesized that the periodization model employed would not impact upon training-induced adaptations when exercise variables are equated. METHODS: Nineteen females (22.0 years, moderate resistance training experience of 27.9 months) performed 6 weeks of knee extensor training with 3 weekly sessions exercising one leg using TP and the contralateral leg using DUP...
February 3, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28159680/long-term-results-of-letournel-scapulothoracic-fusion-in-facioscapulohumeral-muscular-dystrophy-a-retrospective-study-of-eight-cases
#17
Malo Le Hanneur, Yann Saint-Cast
BACKGROUND: The aim of this study was to evaluate long-term radio-clinical outcome in scapulothoracic fusion using the Letournel technique (where the fourth rib is passed through the wing of the scapula and cerclage wires are tightened to the two ribs below) for patients suffering from facioscapulohumeral muscular dystrophy (FSHMD), a degenerative pathology affecting scapula-stabilizing muscles, leading to scapular winging, shoulder pain and restricted shoulder abduction and flexion, despite a functional deltoid muscle...
January 31, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28159637/transcranial-magnetic-stimulation-tms-responses-elicited-in-hindlimb-muscles-as-an-assessment-of-synaptic-plasticity-in-spino-muscular-circuitry-after-chronic-spinal-cord-injury
#18
Hayk A Petrosyan, Valentina Alessi, Sue A Sisto, Mark Kaufman, Victor L Arvanian
Electromagnetic stimulation applied at the cranial level, i.e. transcranial magnetic stimulation (TMS), is a technique for stimulation and neuromodulation used for diagnostic and therapeutic applications in clinical and research settings. Although recordings of TMS elicited motor-evoked potentials (MEP) are an essential diagnostic tool for spinal cord injured (SCI) patients, they are reliably recorded from arm, and not leg muscles. Mid-thoracic contusion is a common SCI that results in locomotor impairments predominantly in legs...
January 31, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28153611/phosphoglycerol-dihydroceramide-a-distinctive-ceramide-produced-by-porphyromonas-gingivalis-promotes-rankl-induced-osteoclastogenesis-by-acting-on-non-muscle-myosin-ii-a-myh9-an-osteoclast-cell-fusion-regulatory-factor
#19
Hiroyuki Kanzaki, Alexandru Movila, Rayyan Kayal, Marcelo H Napimoga, Kenji Egashira, Floyd Dewhirst, Hajime Sasaki, Mohammed Howait, Ayman Al-Dharrab, Abdulghani Mira, Xiaozhe Han, Martin A Taubman, Frank C Nichols, Toshihisa Kawai
Among several virulence factors produced by the periodontal pathogen Porphyromonas gingivalis (Pg), a recently identified novel class of dihydroceramide lipids that contains a long acyl-chain has the potential to play a pathogenic role in periodontitis because of its higher level of tissue penetration compared to other lipid classes produced by Pg. However, the possible impact of Pg ceramides on osteoclastogenesis is largely unknown. In the present study, we report that the phosphoglycerol dihydroceramide (PGDHC) isolated from Pg enhanced osteoclastogenesis in vitro and in vivo...
January 31, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28153456/perinatal-undernutrition-associated-to-experimental-model-of-cerebral-palsy-increases-adverse-effects-on-chewing-in-young-rats
#20
Diego Cabral Lacerda, Kelli Nogueira Ferraz-Pereira, Diego Bulcão Visco, Paula Brielle Pontes, Wenicius Ferreira Chaves, Omar Guzman-Quevedo, Raul Manhães-de-Castro, Ana Elisa Toscano
The aim of the present study was to investigate the effect of perinatal undernutrition on the sensorimotor pattern of chewing in rats submitted to cerebral palsy experimental model. A total of 60 male Wistar rats were randomly distributed into four groups: Nourished/Control (NC, n=15), Nourished/Cerebral Palsy (NCP, n=15); Undernourished/Control (UC, n=15) and Undernourished/Cerebral Palsy (UCP, n=15). Animals of cerebral palsy (CP) group were subjected to an experimental model based on the combination of perinatal anoxia associated with sensorimotor restriction of the hindlimb...
January 30, 2017: Physiology & Behavior
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