Ali Akbar Ashkarran, Soheyl Tadjiki, Zijin Lin, Kylie Hilsen, Noor Ghazali, Sarah Krikor, Shahriar Sharifi, Meisam Asgari, Michael Hotchkin, Adam Dorfman, Karen S Ho, Morteza Mahmoudi
The interaction between nanoparticles (NPs) and biological environments is profoundly influenced by a stable, strongly adsorbed "hard" protein corona. This corona significantly determines the NPs' pharmacokinetics and biological destiny. Our study delves into the mechanisms by which colloidal Au nanocrystals that are synthesized electrochemically without surface-capping organic ligands, known as CNM-Au8, traverse the blood-brain barrier (BBB) and target human brain tissue for treating neurodegenerative disorders...
April 12, 2024: ACS Pharmacology & Translational Science