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https://www.readbyqxmd.com/read/27906777/asymptomatic-bacteriuria-to-screen-or-not-to-screen-and-when-to-treat
#1
Tommaso Cai, Bela Koves, Truls E Bjerklund Johansen
PURPOSE OF REVIEW: Asymptomatic bacteriuria (ABU) is a common clinical condition that often leads to unnecessary treatment. The purpose of this review is to outline and evaluate the most recent literature on the management of ABU. RECENT FINDINGS: The role of ABU management has been evaluated in several patient subgroups: healthy patients without identified risk factors, pregnant women, postmenopausal women, women with recurrent UTI, patients with diabetes, elderly institutionalized patients, patients with renal transplants, patients with indwelling catheters and prior to surgery...
November 30, 2016: Current Opinion in Urology
https://www.readbyqxmd.com/read/27871759/rabbit-atg-or-basiliximab-induction-for-rapid-steroid-withdrawal-after-renal-transplantation-harmony-an-open-label-multicentre-randomised-controlled-trial
#2
Oliver Thomusch, Michael Wiesener, Mirian Opgenoorth, Andreas Pascher, Rainer Peter Woitas, Oliver Witzke, Bernd Jaenigen, Markus Rentsch, Heiner Wolters, Thomas Rath, Tülay Cingöz, Urs Benck, Bernhard Banas, Christian Hugo
BACKGROUND: Standard practice for immunosuppressive therapy after renal transplantation is quadruple therapy using antibody induction, low-dose tacrolimus, mycophenolate mofetil, and corticosteroids. Long-term steroid intake significantly increases cardiovascular risk factors with negative effects on the outcome, especially post-transplantation diabetes associated with morbidity and mortality. In this trial, we examined the efficacy and safety parameters of rapid steroid withdrawal after induction therapy with either rabbit antithymocyte globulin (rabbit ATG) or basiliximab in immunologically low-risk patients during the first year after kidney transplantation...
November 18, 2016: Lancet
https://www.readbyqxmd.com/read/27696238/embryonic-kidney-function-in-a-chronic-renal-failure-model-in-rodents
#3
Eisuke Fujimoto, Shuichiro Yamanaka, Sho Kurihara, Susumu Tajiri, Luna Izuhara, Yuichi Katsuoka, Shinya Yokote, Kei Matsumoto, Eiji Kobayashi, Hirotaka James Okano, Tatsuya Chikaraishi, Takashi Yokoo
BACKGROUND: Rapid advancements have been made in alternative treatments for renal diseases. Our goal for renal regeneration is to establish a kidney graft derived from human embryonic tissues. In this study, we investigated the effects of host renal failure on the structure and activity of transplanted embryonic kidney and bladder, and found that diuretics effectively induced urine production in the transplanted kidney. METHODS: Uremic conditions were reproduced using a 5/6 renal infarction rat model...
September 30, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27667505/the-importance-of-nonstop-treatment-after-delivery-for-pregnant-women-with-type-2-diabetes
#4
Yasue Omori, Keiko Yanagisawa, Asako Sato, Yasuko Uchigata
BACKGROUND: There are no reports of very long follow-up studies of pregnant women with type 2 diabetes after delivery. Here we describe cases of Japanese women whom we treated for 20 to 50 years after deliveries to investigate the relationship between blood glucose control and diabetic complications. METHODS: In Japan, the prevalence of type 1 diabetes is very low, and we have very few long-term follow-up cases with type 1 diabetes. Therefore, we chose to describe subjects with type 2 diabetes only...
September 26, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27649578/aspiration-of-immature-oocytes-during-cesarean-section-for-fertility-preservation
#5
Avi Ben-Haroush, Ronit Abir, Onit Sapir, Roni Garor, Benjamin Fisch
BACKGROUND: In vitro maturation of immature oocytes is an important technology for selected clinical indications. We previously described a pregnant woman with a history of renal transplantation who underwent oocyte aspiration during cesarean section (CS) for fertility preservation and future surrogacy. CASE: A 27-year-old pregnant woman was diagnosed with neck rhabdomyosarcoma at 37 weeks' gestation. CS was performed with direct aspiration of small follicles from one ovary and oophorectomy of the other...
September 21, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27586504/the-influence-of-exposure-to-immunosuppressive-treatment-during-pregnancy-on-renal-function-and-rate-of-apoptosis-in-native-kidneys-of-female-wistar-rats
#6
Joanna Kabat-Koperska, Agnieszka Kolasa-Wołosiuk, Irena Baranowska-Bosiacka, Krzysztof Safranow, Danuta Kosik-Bogacka, Izabela Gutowska, Anna Pilutin, Edyta Gołembiewska, Karolina Kędzierska, Kazimierz Ciechanowski
Pregnancy puts a significant additional strain on kidneys. The aim of our study was to investigate the impact of immunosuppressive drugs on changes in native kidneys in female Wistar rats after exposure during pregnancy. The study was conducted on 32 dams, subjected to immunosuppressive regimens commonly used in the therapy of human kidney transplant recipients (cyclosporine A, mycophenolate mofetil and prednisone; tacrolimus, mycophenolate mofetil and prednisone; cyclosporine A, everolimus and prednisone)...
November 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27496481/hypertension-in-pregnant-renal-and-liver-transplant-recipients
#7
A Madej, B Pietrzak, N Mazanowska, T Songin, B Kociszewska-Najman, A Cyganek, Z Jabiry-Zieniewicz, M Wielgos
BACKGROUND: Pregnancies in transplant recipients involve risks for both grafts and the fetus, and need to be carefully managed. Hypertension is the most frequent complications in pregnant transplant recipients, especially in renal transplant recipients. Strict control of blood pressure is essential for a favorable obstetric outcome and long-term graft survival. The aim of the study was to evaluate the influence of hypertension on obstetric outcome and graft function in pregnant renal transplant recipients (RTR) or liver transplant recipients (LTR) in comparison with healthy pregnant women...
June 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27274831/high-prevalence-of-chronic-kidney-disease-in-a-semi-urban-population-of-western-india
#8
Hargovind Trivedi, Aruna Vanikar, Himanshu Patel, Kamal Kanodia, Vivek Kute, Lovelesh Nigam, Kamlesh Suthar, Umang Thakkar, Harsh Sutariya, Shruti Gandhi
BACKGROUND: Globally there is an increase in incidence of chronic kidney diseases (CKDs). Diabetes mellitus (DM), hypertension and stone diseases are the major risk factors for CKD. We organized kidney disease screening camps in a semi-urban population of Gujarat, India on the occasion of World Kidney Day (WKD). METHODS: Voluntary participants from six towns were screened. Estimated glomerular filtration rate (eGFR) was calculated by the Modification of Diet in Renal Disease formula and CKD was defined as an eGFR <60 mL/min/1...
June 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/27196355/report-from-the-international-conference-on-viral-hepatitis-icvh-san-francisco-march-2016
#9
Vicente Soriano, Benjamin Young, Norah Terrault
The International Conference on Viral Hepatitis 2016 brought exciting news on the treatment of viral hepatitis. The conference was mainly focused on the most recent estimates of burden for HBV and HCV; the current gaps and prospects for regional and global HCV eradication; the use of HCV treatment as prevention; and the management of difficult-to-cure hepatitis C patients, including individuals who fail on direct-acting antivirals, people who inject drugs, and those with decompensated cirrhosis or renal insufficiency...
April 2016: AIDS Reviews
https://www.readbyqxmd.com/read/27125396/factors-related-to-deterioration-of-renal-function-after-singleton-delivery-in-pregnant-women-with-chronic-kidney-disease
#10
Yuko Fukasawa, Yasuo Makino, Masaki Ogawa, Keiko Uchida, Hideo Matsui
OBJECTIVE: This study is designed to evaluate which factors would relate to deterioration of renal function (DRF) after delivery in pregnant women with chronic kidney disease (CKD). MATERIALS AND METHODS: This study included 156 singleton pregnancies of 139 women with CKD at our institution from 2001 to 2010. DRF was defined as the shift of CKD stage into another more severe stage. The relevant variables were compared between women who had DRF (n = 39) and the controls (n = 117)...
April 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27058329/-determination-of-cytomegalovirus-glycoprotein-b-genotypes-in-different-geographical-regions-and-different-patient-groups-in-turkey
#11
Duygu Eren Dağlar, Gözde Öngüt, Dilek Çolak, Aykut Özkul, Derya Mutlu, Ayşın Zeytinoğlu, Kenan Midilli, Selma Gökahmetoğlu, Filiz Günseren, Dilara Öğünç, Meral Gültekin
Cytomegalovirus (CMV), a common virus found all around the world, usually causes asymptomatic infections in immunocompetent hosts, however it may lead to serious complications in immunodeficient patients and in the fetus. CMV is divided into four genotypes according to the polymorphisms in UL55 gene that encodes for envelope glycoprotein B. Nucleotide polymorphisms of CMV gB gene can affect the cell tropism of the virus and host immune response and believed to have important changes in the pathogenesis of CMV...
January 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/26992458/obstetric-and-long-term-kidney-outcomes-in-renal-transplant-recipients-a-40-yr-single-center-study
#12
Sokratis Stoumpos, Susan H McNeill, Morag Gorrie, Patrick B Mark, Janet E Brennand, Colin C Geddes, Christopher J Deighan
Female renal transplant recipients of childbearing age may ask what the outcomes are for pregnancy and whether pregnancy will affect graft function. We analyzed obstetric and transplant outcomes among renal transplant recipients in our center who have been pregnant between 1973 and 2013. A case-cohort study was performed identifying 83 pairs of pregnant and non-pregnant controls matched for sex, age, transplant vintage, and creatinine. There were 138 pregnancies reported from 89 renal transplant recipients...
June 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/26946063/timing-of-pregnancy-after-kidney-transplantation-and-risk-of-allograft-failure
#13
C Rose, J Gill, N Zalunardo, O Johnston, A Mehrotra, J S Gill
The optimal timing of pregnancy after kidney transplantation remains uncertain. We determined the risk of allograft failure among women who became pregnant within the first 3 posttransplant years. Among 21 814 women aged 15-45 years who received a first kidney-only transplant between 1990 and 2010 captured in the United States Renal Data System, n = 729 pregnancies were identified using Medicare claims. The probability of allograft failure from any cause including death (ACGL) at 1, 3, and 5 years after pregnancy was 9...
August 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/26892892/administration-of-antithymocyte-globulin-rabbit-to-treat-a-severe-mixed-rejection-episode-in-a-pregnant-renal-transplant-recipient
#14
Heather L Kutzler, Xiaoyi Ye, Caroline Rochon, Spencer T Martin
Pregnancy in solid organ transplant recipients carries numerous risks to the mother such as increased risk of rejection, gestational diabetes mellitus, and preeclampsia. The developing fetus is subjected to risks such as birth defects, preterm delivery, and low birth weight. Typically, these risks can be managed through intensive, multidisciplinary prenatal care and a proper immunosuppressive regimen. In the setting of rejection, however, little data are available to suggest safe and effective treatment of acute cellular rejection, antibody-mediated rejection, or mixed rejection episodes in the pregnant solid organ transplant recipient...
April 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/26767122/pregnancy-management-of-women-with-kidney-transplantation
#15
Dávid Ágoston Kovács, László Szabó, Katalin Jenei, Roland Fedor, Gergely Zádori, Lajos Zsom, Krisztina Kabai, Anita Záhonyi, László Asztalos, Balázs Nemes
Women with renal disease, besides many dysfunctions, face increasing infertility and high-risk pregnancy due to uremia and changes of the hormonal functions. After renal transplantation, sexual dysfunction improves, providing the possibility of successful pregnancy for women of childbearing age. However, kidney transplanted patients are high-risk pregnant patients with increased maternal and fetal risks, and the graft also may be compromised during pregnancy; most studies report on several successive deliveries due to multidisciplinary team management...
December 2015: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/25920920/lupus-nephritis-management-guidelines-compared
#16
Suzanne Wilhelmus, Ingeborg M Bajema, George K Bertsias, Dimitrios T Boumpas, Caroline Gordon, Liz Lightstone, Vladimir Tesar, David R Jayne
In the past years, many (randomized) trials have been performed comparing the treatment strategies for lupus nephritis. In 2012, these data were incorporated in six different guidelines for treating lupus nephritis. These guidelines are European, American and internationally based, with one separate guideline for children. They offer information on different aspects of the management of lupus nephritis including induction and maintenance treatment of the different histological classes, adjunctive treatment, monitoring of the patient, definitions of response and relapse, indications for (repeat) renal biopsy, and additional challenges such as the presence of vascular complications, the pregnant SLE patient, treatment in children and adolescents and considerations about end-stage renal disease and transplantation...
June 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/25815535/pregnancy-in-kidney-transplanted-women-what-are-the-optimal-conditions-for-a-better-pregnancy-outcome
#17
REVIEW
Amine Ben Haj Hassine, Haythem Siala, Mohamed Basly, Kais Harzallah, Mounir Chibani, Radhouane Rachdi
BACKGROUND: Motherhood has long been not recommended for kidney transplanted women for fear of adverse effects on the graft and the risks to the fetus. AIMS: This article aimed to provide evidence based answer to the following questions regarding pregnancy in kidney transplanted women: 1. what are the nephrologic and obstetrical parameters that can influence the pregnancy outcome? 2. What is the impact of pregnancy on graft? 3. What are the optimal conditions for pregnancy planning in kidney transplanted women? METHODS: A literature search was conducted using as key words "pregnancy", "renal transplant", "renal graft survival" in the PubMed database over the period from January 1994 to December 2011...
August 2014: La Tunisie Médicale
https://www.readbyqxmd.com/read/25787613/-263-pos-psychological-assessment-of-renal-transplant-recipients-during-pregnancy
#18
Vera L Belardi Neto
OBJECTIVES: (1) To identify the psychological sense of motherhood to these women who have submitted kidney transplantation, (2) to verify if the socio-cultural and religious aspects are involved in desire to get pregnant METHODS: Fourteen pregnant kidney transplantation women with average of 27.5years were included in the study. All patients investigated beyond the 20th week of pregnancy to delivery. This study is cross-sectional and participation is based on developed phenomenological method...
January 2015: Pregnancy Hypertension
https://www.readbyqxmd.com/read/25787569/-219-pos-tacrolimus-as-the-first-choice-of-immunosuppressive-therapy-in-kidney-transplantation-pregnant-did-not-reduce-significantly-maternal-and-perinatal-risks-a-preliminary-analysis
#19
Nelson Sass, Jussara L Sato, Thais A Facca, Vinicius A C C Gomes, Hélio T Silva Júnior, Maria R S Mesquita, Henri A Korkes, Leandro G Oliveira
OBJECTIVES: There has been an increase in the number of pregnancies in renal transplant recipients. In recent years there has been a change from the option of immunosuppressive therapy in its patients. Unlike the previous standard of clinical care where cyclosporine was a common option, currently tacrolimus is the first choice in our group. However both options involve risks. Thus, our goal is a preliminary evaluation of maternal and perinatal outcomes of this new interaction. METHODS: Eighteen patients from January 2011 to December 2013 were evaluated as clinical, obstetrical and perinatal outcomes...
January 2015: Pregnancy Hypertension
https://www.readbyqxmd.com/read/25709284/serial-ultra-wide-field-imaging-for-following-up-acute-retinal-necrosis-cases
#20
Koushik Tripathy, Yog Raj Sharma, Varun Gogia, Pradeep Venkatesh, Subodh Kumar Singh, Rajpal Vohra
We describe two cases of acute retinal necrosis (ARN) in a post renal transplant diabetic patient and a pregnant female in the first trimester. Serial ultra wide field imaging (UWFI) with comprehensive ocular examination was done to monitor the progression of the disease. All the cases responded favorably with intravenous followed by oral acyclovir, which was captured with UWFI. UWFI provides objective proof of response to therapy in ARN. UWFI may also improve patient education and counseling for this peripheral retinal disorder...
January 2015: Oman Journal of Ophthalmology
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