keyword
MENU ▼
Read by QxMD icon Read
search

EMT renal

keyword
https://www.readbyqxmd.com/read/28523000/mast-cells-and-mcpt4-chymase-promote-renal-impairment-after-partial-ureteral-obstruction
#1
Maguelonne Pons, Liza Ali, Walid Beghdadi, Luca Danelli, Marianne Alison, Lydia Celia Madjène, Jessica Calvo, Julien Claver, Shamila Vibhushan, Magnus Åbrink, Gunnar Pejler, Marie-Laurence Poli-Mérol, Michel Peuchmaur, Alaa El Ghoneimi, Ulrich Blank
Obstructive nephropathy constitutes a major cause of pediatric renal progressive disease. The mechanisms leading to disease progression are still poorly understood. Kidney fibrotic lesions are reproduced using a model of partial unilateral ureteral obstruction (pUUO) in newborn mice. Based on data showing significant mast cell (MC) infiltration in patients, we investigated the role of MC and murine MCPT4, a MC-released chymase, in pUUO using MC- (W(sh/sh)), MCPT4-deficient (Mcpt4(-/-)), and wild-type (WT) mice...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28501426/attenuation-of-diabetic-nephropathy-by-sanziguben-granule-inhibiting-emt-through-nrf2-mediated-anti-oxidative-effects-in-streptozotocin-stz-induced-diabetic-rats
#2
Chenxue Zhang, Qian Li, Sisi Lai, Lei Yang, Guoqi Shi, Qing Wang, Zijie Luo, Ruizhi Zhao, Yang Yu
ETHNOPHARMACOLOGICAL RELEVANCE: Diabetic nephropathy (DN) is an acute and serious diabetic complication characterized by renal hypertrophy and renal fibrosis with the expansion of extracellular matrices. Diabetic nephropathy has become a major cause of end-stage kidney disease. Sanziguben Granule (SZGB) is a compound prescription which has been widely applied in clinical medicine for the prevention and treatment of diabetic nephropathy as well as for acute and chronic kidney injuries...
May 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28492542/lncrna-hotair-regulates-hif-1%C3%AE-axl-signaling-through-inhibition-of-mir-217-in-renal-cell-carcinoma
#3
Quan Hong, Ou Li, Wei Zheng, Wen-Zhen Xiao, Lu Zhang, Di Wu, Guang-Yan Cai, John Cijiang He, Xiang-Mei Chen
Long non-coding RNA HOTAIR was regarded as an oncogene in multiple cancers. Previous studies have shown that HOTAIR is involved in the proliferation and tumorigenesis of renal carcinoma cells, while microRNA (miR)-217 functions as a tumor suppressor in renal cell carcinoma (Rcc). However, the underlying molecular mechanism of HOTAIR in Rcc, especially in association with miR-217, has not been studied. In this study, we first demonstrated that HOTAIR expression was upregulated, which was correlated with tumor progression, and miR-217 downregulated in Rcc tissues and cells...
May 11, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28487942/cyclic-amp-responsive-element-binding-protein-induces-metastatic-renal-cell-carcinoma-by-mediating-the-expression-of-matrix-metallopeptidase-2-9-and-proteins-associated-with-epithelial-mesenchymal-transition
#4
Xue Wang, Hui Cui, Zhongguan Lou, Shuaishuai Huang, Yu Ren, Ping Wang, Guobin Weng
Renal cell carcinoma (RCC) is the most frequently occurring malignancy of the kidney worldwide. Anti-angiogenic targeted therapies inhibit the progression of RCC, however, limited effects on the invasion or metastasis of tumor cells have been observed. Cyclic AMP responsive element‑binding protein (CREB) is a serine/threonine kinase that has been implicated in the regulation of cell proliferation, apoptosis, cycle progression and metastasis, amongst others. Our previous research demonstrated that phosphorylated CREB (pCREB) was upregulated in human renal cancer cell lines and tissues, and decreased pCREB at the Ser133 site inhibited the growth and metastatic activity of OS‑RC‑2 cells...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28479251/csn5-promotes-renal-cell-carcinoma-metastasis-and-emt-by-inhibiting-zeb1-degradation
#5
Shouhua Zhang, Zhengdong Hong, Yong Chai, Zhiqiang Liu, Yunyan Du, Qiang Li, Queling Liu
CSN5 (also known as COPS5) is a newly characterized oncogene involved in various types of cancer. However, its expression pattern and biological functions in renal cell carcinoma (RCC) is unknown. Here, we found that CSN5 expression was elevated in RCC tissues than those in paired normal renal tissues. Additionally, we demonstrated that high CSN5 level was closely correlated with tumor progression and poor survival in RCC patients. Our results showed that increased expression of CSN5 was observed in RCC cell lines and knockdown of CSN5 significantly suppressed the migration and invasion of RCC cells in vitro and in vivo...
June 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28463799/qi-zhu-xie-zhuo-fang-reduces-serum-uric-acid-levels-and-ameliorates-renal-fibrosis-in-hyperuricemic-nephropathy-rats
#6
Wang Huijuan, Chen Xiaoxu, Song Rui, Li Xinghui, Tao Beibei, Mao Jianchun
Hyperuricemia is associated with the development of chronic kidney disease. Epithelial-to-mesenchymal transition (EMT) induced by hyperuricemia is blamed for initiation of renal fibrosis, which is one of the main characters of hyperuricemic nephropathy. Qi-Zhu-Xie-Zhuo-Fang (QZXZF) has been employed clinically for many years to treat patients with hyperuricemic nephropathy, but the mechanism underlying the therapeutic potential remains unclear. In the present study, QZXZF was applied to rats treated with adenine (100mg/kg) and potassium oxonate (300mg/kg) and biochemical estimations, morphology and immunohistochemistry were performed to investigate whether QZXZF can improve hyperuricemia induced renal fibrosis and to explore the possible mechanisms...
April 29, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28460508/-effect-of-febuxostat-on-epithelial-to-mesenchymal-transition-of-kidney-tubules-serum-interleukin-6-and-transforming-growth-factor-%C3%AE-1-in-hyperuricemic-rats
#7
Z M Lin, R S Zhang, C X Fan, Y L Liang, L Li, L Zhao, J C Qu, X Xu, H Y Zhao, X N Liu, K S Zhu
Objective: To observe the effect of febuxostat on epithelial-to-mesenchymal transition (EMT) of kidney tubules and the levels of serum IL-6 nad transforming growth factor (TGF)β(1) in hyperuricemic rats. Methods: Forty male SD rats were divided into 4 groups: normal control group (NC group), oteracil potassium group (OP group), oteracil potassium with febuxostat group (OF group) and oteracil potassium with benzbromarone group (OB group). Each group had 10 rats and balanced in body weights. To induce hyperuricemia, rats were given oteracil potassium by gastric gavage once a day for eight weeks...
May 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28458345/hydrogen-rich-water-attenuates-renal-injury-and-fibrosis-by-regulation-transforming-growth-factor-%C3%AE-induced-sirt1
#8
Zhaoyu Xing, Wanma Pan, Jing Zhang, Xianlin Xu, Xuemei Zhang, Xiaozhou He, Min Fan
The current research was designed to study the role of hydrogen in renal fibrosis and the renal epithelial to mesenchymal transition (EMT) induced by transforming growth factor-β1 (TGF-β1). Hydrogen rich water (HW) was used to treat animal and cell models. Unilateral ureteral obstruction (UUO) was performed on Balb/c mice to create a model of renal fibrosis. Human kidney proximal tubular epithelial cells (HK-2 cells) were treated with TGF-β1 for 36 h to induce EMT. Serum creatinine (Scr) and blood urea nitrogen (BUN) were measured to test renal function, in addition, kidney histology and immunohistochemical staining of alpha-smooth muscle actin (α-SMA) positive cells was performed to examine the morphological changes...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28448446/renalase-protects-against-renal-fibrosis-by-inhibiting-the-activation-of-the-erk-signaling-pathways
#9
Yiru Wu, Liyan Wang, Dai Deng, Qidong Zhang, Wenhu Liu
Renal interstitial fibrosis is a common pathway for the progression of chronic kidney disease (CKD) to end-stage renal disease. Renalase, acting as a signaling molecule, has been reported to have cardiovascular and renal protective effects. However, its role in renal fibrosis remains unknown. In this study, we evaluated the therapeutic efficacy of renalase in rats with complete unilateral ureteral obstruction (UUO) and examined the inhibitory effects of renalase on transforming growth factor-β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) in human proximal renal tubular epithelial (HK-2) cells...
April 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28435451/ahnak2-is-a-novel-prognostic-marker-and-oncogenic-protein-for-clear-cell-renal-cell-carcinoma
#10
Minglei Wang, Xuefeng Li, Jin Zhang, Qiong Yang, Wenqi Chen, Weilin Jin, Yi-Ran Huang, Ru Yang, Wei-Qiang Gao
Integrative database analysis was performed to identify novel candidate oncogene AHNAK2 overexpressed in clear cell renal cell carcinoma (ccRCC). However, the function of AHNAK2 in cancer cells is currently unknown. In this study, we first confirmed the upregulation of AHNAK2 in ccRCC tissues compared with adjacent normal tissues in 15 pairs of samples. Then we analyzed AHNAK2 expression in a large cohort of ccRCC patient samples (n = 355), and found that up-regulation of AHNAK2 was positively correlated with tumor progression and poor survival (p = 0...
2017: Theranostics
https://www.readbyqxmd.com/read/28409352/epithelial-to-mesenchymal-transition-emt-and-endothelial-to-mesenchymal-transition-endmt-role-and-implications-in-kidney-fibrosis
#11
Ana S Cruz-Solbes, Keith Youker
Tubulointerstitial injury is one of the hallmarks of renal disease. In particular, interstitial fibrosis has a prominent role in the development and progression of kidney injury. Collagen-producing fibroblasts are responsible for the ECM deposition. However, the origin of those activated fibroblasts is not clear. This chapter will discuss in detail the concept of epithelial to mesenchymal transition (EMT) and endothelial to mesenchymal transition (EndMT) in the context of fibrosis and kidney disease. In short, EMT and EndMT involve a change in cell shape, loss of polarity and increased motility associated with increased collagen production...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/28408805/effect-of-berberine-on-the-renal-tubular-epithelial-to-mesenchymal-transition-by-inhibition-of-the-notch-snail-pathway-in-diabetic-nephropathy-model-kkay-mice
#12
Guannan Yang, Zongjiang Zhao, Xinxue Zhang, Amin Wu, Yawei Huang, Yonghui Miao, Meijuan Yang
Renal tubular epithelial-to-mesenchymal transition (EMT) and renal tubular interstitial fibrosis are the main pathological changes of diabetic nephropathy (DN), which is a common cause of end-stage renal disease. Previous studies have suggested that berberine (BBR) has antifibrotic effects in the kidney and can reduce apoptosis and inhibit the EMT of podocytes in DN. However, the effect of BBR on the renal tubular EMT in DN and its mechanisms of action are unknown. This study was performed to explore the effects of BBR on the renal tubular EMT and the molecular mechanisms of BBR in DN model KKAy mice and on the high glucose (HG)-induced EMT in mouse renal tubular epithelial cells...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28408246/renal-protective-effect-and-action-mechanism-of-huangkui-capsule-and-its-main-five-flavonoids
#13
Hong-Die Cai, Shu-Lan Su, Da-Wei Qian, Sheng Guo, Wei-Wei Tao, Xu Dong Cong, Renmao Tang, Jin-Ao Duan
ETHNOPHARMACOLOGICAL RELEVANCE: The flower of Abelmoschus manihot (Linn.) Medicus (A. manihot), as a traditional Chinese Herbal medicine, was used widely in China with efficacy of inducing diuresis for treating strangurtia, and subdhing swelling and detoxicating. It has been reported that Huangkui capsule, prepared by the extract of the flower of A. manihot, can reduce the content of urinary protein, serum creatinine and serum urea nitrogen in nephropathy rats and processes renoprotective activity, while the action mechanism need to illuminate deeply...
April 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28406456/metronomic-cordycepin-therapy-prolongs-survival-of-oral-cancer-bearing-mice-and-inhibits-epithelial-mesenchymal-transition
#14
Nai-Wen Su, Shu-Hua Wu, Chih-Wen Chi, Chung-Ji Liu, Tung-Hu Tsai, Yu-Jen Chen
Cordycepin (3'-deoxyadenosine) is a natural compound abundantly found in Cordyceps sinesis in natural and fermented sources. In this study, we examined the effects of cordycepin in a human oral squamous cell carcinoma (OSCC) xenograft model. Cordycepin was administered in a regular, low-dose and prolonged schedule metronomic therapy. Two doses of cordycepin (25 mg/kg, 50 mg/kg) were administrated five days a week for eight consecutive weeks. The tumor volumes were reduced and survival time was significantly prolonged from 30...
April 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28394941/correction-heparanase-a-potential-new-factor-involved-in-the-renal-epithelial-mesenchymal-transition-emt-induced-by-ischemia-reperfusion-i-r-injury
#15
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0160074.].
2017: PloS One
https://www.readbyqxmd.com/read/28393205/high-annexin-a5-expression-promotes-tumor-progression-and-poor-prognosis-in-renal-cell-carcinoma
#16
Jingyuan Tang, Zhiqiang Qin, Peng Han, Wei Wang, Chengdi Yang, Zhen Xu, Ran Li, Bianjiang Liu, Chao Qin, Zengjun Wang, Min Tang, Wei Zhang
Annexin A5 has been found to act as an oncogenic protein in a variety of cancers. However, its specific biological role and mechanism in renal cell cancer (RCC) remains unknown. Quantitative Real-time PCR and western blotting were used to evaluate the mRNA and protein expression level of Annexin A5 in human RCC cell lines and tissues. Immunohistochemistry was adopted to measure the Annexin A5 expression in 123 cases of RCC tissues. Survival analysis was performed to explore the association between Annexin A5 expression and the prognosis of RCC...
April 3, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28387228/calcium-oxalate-crystals-and-oxalate-induce-an-epithelial-to-mesenchymal-transition-in-the-proximal-tubular-epithelial-cells-contribution-to-oxalate-kidney-injury
#17
Marcia Bastos Convento, Edson Andrade Pessoa, Edgar Cruz, Maria Aparecida da Glória, Nestor Schor, Fernanda Teixeira Borges
TGF-β1 is the main mediator of epithelial-to-mesenchymal transition (EMT). Hyperoxaluria induces crystalluria, interstitial fibrosis, and progressive renal failure. This study analyzed whether hyperoxaluria is associated with TGF-β1 production and kidney fibrosis in mice and if oxalate or calcium oxalate (CaOx) could induce EMT in proximal tubule cells (HK2) and therefore contribute to the fibrotic process. Hyperoxaluria was induced by adding hydroxyproline and ethylene glycol to the mice's drinking water for up to 60 days...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28385574/ouabain-promotes-partial-epithelial-to-mesenchymal-transition-emt-changes-in-human-autosomal-dominant-polycystic-kidney-disease-adpkd-cells
#18
Jessica Venugopal, Jeffrey McDermott, Gladis Sanchez, Madhulika Sharma, Leandro Barbosa, Gail A Reif, Darren P Wallace, Gustavo Blanco
The hormone ouabain has been shown to enhance the cystic phenotype of autosomal dominant polycystic kidney disease (ADPKD). Among other characteristics, the ADPKD phenotype includes cell de-differentiation and epithelial to mesenchymal transition (EMT). Here, we determined whether physiological concentrations of ouabain induces EMT in human renal epithelial cells from patients with ADPKD. We found that ADPKD cells respond to ouabain with a decrease in expression of the epithelial marker E-cadherin and increase in the expression of the mesenchymal markers N-cadherin, α smooth muscle actin (αSMA) and collagen-I; and the tight junction protein occludin and claudin-1...
April 3, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28378840/alpha-lipoic-acid-ameliorates-the-epithelial-mesenchymal-transition-induced-by-unilateral-ureteral-obstruction-in-mice
#19
Hyun Seop Cho, Jin Hyun Kim, Ha Nee Jang, Tae Won Lee, Myeong Hee Jung, Tae Ho Kim, Se-Ho Chang, Dong Jun Park
The epithelial-to-mesenchymal transition (EMT) is one of mechanisms that induce renal interstitial fibrosis. Understanding EMT in renal fibrosis has important therapeutic implications for patients with kidney disease. Alpha-lipoic acid (ALA) is a natural compound with antioxidant properties. Studies for ALA are performed in acute kidney injury with renal tubular apoptosis, renal inflammation, and oxidative stress. We investigated the effects of ALA on EMT-mediated renal interstitial fibrosis in mice with unilateral ureteral obstruction (UUO)...
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28374152/uric-acid-activates-nrlp3-inflammasome-in-an-in-vivo-model-of-epithelial-to-mesenchymal-transition-in-the-kidney
#20
César Andrés Romero, Aline Remor, Alexandra Latini, Ana Lucía De Paul, Alicia Inés Torres, Jorge Humberto Mukdsi
Uric acid (UA) has been associated with renal fibrosis and progression of chronic kidney disease. However, the underlying mechanisms of this process have still not been identified. Here, we studied the role of the innate imunity receptor NLRP3/ASC in UA induced epithelial-mesenchymal transition (EMT) in kidney. Wistar rats were fed with oxonic acid 2% and UA 2% (OXA + U), OXA + U plus allopurinol (ALL) or regular chow (C) for 7 weeks. We analyzed the presence of EMT markers, the expression of NLRP3, ASC, Caspase-1 and Smad 2/3 molecules and the mitochondrial morphological and functional characteristics...
April 3, 2017: Journal of Molecular Histology
keyword
keyword
45231
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"