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https://www.readbyqxmd.com/read/28929120/sulodexide-protects-renal-tubular-epithelial-cells-from-oxidative-stress-induced-injury-via-upregulating-klotho-expression-at-an-early-stage-of-diabetic-kidney-disease
#1
Yu Ning Liu, Jingwei Zhou, Tingting Li, Jing Wu, Shu Hua Xie, Hua-Feng Liu, Zhangsuo Liu, Tae Sun Park, Yaoxian Wang, Wei Jing Liu
The hypoalbuminuric effect of sulodexide (SDX) on diabetic kidney disease (DKD) was suggested by some clinical trials but was denied by the Collaborative Study Group. In this study, the diabetic rats were treated with SDX either from week 0 to 24 or from week 13 to 24. We found that 24-week treatment significantly decreased the urinary protein and HAVCR1 excretion, inhibited the interstitial expansion, and downregulated the renal cell apoptosis and interstitial fibrosis. Renoprotection was also associated with a reduction in renocortical/urinary oxidative activity and the normalization of renal klotho expression...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28920823/diagnosis-and-treatment-of-a-unilateral-renal-cystadenoma-in-an-african-lion-panthera-leo
#2
Ronan Eustace, Jacob Rubin, Kimberly A Thompson, Kyle Snowdon, James G Sikarskie, Colleen Monahan, Rebecca C Smedley
A renal tubular cystadenoma was diagnosed in a 14-yr-old male African lion (Panthera leo). During a routine health evaluation, a left renal mass was identified via physical examination, radiographs, and abdominal ultrasonography. The mass was 30 × 15 cm in size and had a thin capsule with central hypoechoic fluid, suggestive of a perirenal cyst. An exploratory celiotomy with partial nephrectomy was performed without complications. Histologically, the tumor was characterized by a thick fibrous capsule surrounding multiple, variable-sized cysts that markedly compressed the adjacent fibrotic and atrophied renal cortex...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28919632/cd36-in-chronic-kidney-disease-novel-insights-and-therapeutic-opportunities
#3
REVIEW
Xiaochun Yang, Daryl M Okamura, Xifeng Lu, Yaxi Chen, John Moorhead, Zac Varghese, Xiong Z Ruan
CD36 (also known as scavenger receptor B2) is a multifunctional receptor that mediates the binding and cellular uptake of long-chain fatty acids, oxidized lipids and phospholipids, advanced oxidation protein products, thrombospondin and advanced glycation end products, and has roles in lipid accumulation, inflammatory signalling, energy reprogramming, apoptosis and kidney fibrosis. Renal CD36 is mainly expressed in tubular epithelial cells, podocytes and mesangial cells, and is markedly upregulated in the setting of chronic kidney disease (CKD)...
September 18, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28912882/atorvastatin-alleviates-iodinated-contrast-media-induced-cytotoxicity-in-human-proximal-renal-tubular-epithelial-cells
#4
Gai-Ling Liu, Rong Lei, Shao-Bin Duan, Mi-Mi Tang, Min Luo, Qian Xu
Contrast media (CM)-induced nephropathy (CIN) is a serious complication of intravascularly applied radiocontrast media. At present, no drugs have been approved for the prevention of CIN. The present study aimed to explore the effects and potential mechanisms of atorvastatin on iodinated CM-induced cytotoxicity in the human proximal renal tubular epithelial cells. The cytotoxic effect of iohexol (50, 100 and 200 mg I/ml) and the protective effect of atorvastatin pretreatment (1, 20 and 40 µM) were assessed...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28903918/-pro-renin-receptor-mediates-albumin-induced-cellular-responses-role-of-site-1-protease-derived-soluble-pro-renin-receptor-in-renal-epithelial-cells
#5
Hui Fang, Chuanming Xu, Aihua Lu, Chang-Jiang Zou, Shiying Xie, Yanting Chen, Li Zhou, Mi Liu, Lei Wang, Weidong Wang, Tianxin Yang
Proteinuria is a characteristic of chronic kidney disease (CKD) and also a causative factor that promotes the disease progression in part via activation of intrarenal renin-angiotensin system (RAS). (Pro) renin receptor (PRR), a newly discovered component of the RAS, binds renin and (pro) renin to promote angiotensin I generation. The present study was performed to test the role of soluble PRR (sPRR) in albumin overload-induced responses in cultured human renal proximal tubular cell line HK-2 cells. Bovine serum albumin (BSA) treatment for 24 h at 20 mg/ml induced renin activity and inflammation, both of which were attenuated by a PRR decoy inhibitor PRO20...
September 13, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28901491/mir%C3%A2-21-attenuates-contrast%C3%A2-induced-renal-cell-apoptosis-by-targeting-pdcd4
#6
Kun Wang, Wei-Jie Bei, Yuan-Hui Liu, Hua-Long Li, Shi-Qun Chen, Kai-Yang Lin, Zhi-Ling Zhou, Ji-Yan Chen, Yong Liu, Ning Tan
Contrast medium (CM) is widely used in cardiac catheterization; however, it may induce acute kidney injury or renal failure, although the underlying mechanism remains to be elucidated. MicroRNA‑21 (miR‑21) is involved in renal disease and has been indicated to regulate cellular apoptosis and fibrosis, although its role in CM‑induced renal cell injury is unknown. The present study examined the expression and potential targets of miR‑21 in human renal proximal tubular epithelial (HK‑2) cells following CM treatment...
September 5, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28877724/characteristics-of-lipid-metabolism-including-serum-apolipoprotein-m-levels-in-patients-with-primary-nephrotic-syndrome
#7
Lagu He, Pengfei Wu, Li Tan, Bai Le, Wenhan Du, Ting Shen, Jiali Wu, Zheyi Xiang, Min Hu
BACKGROUND: Apolipoprotein M (apoM) is a 26-kD apolipoprotein that is mainly expressed in specific cell types, such as human liver parenchymal cells and kidney proximal renal tubular epithelial cells. ApoM can regulate the formation of pre-β-HDL and the reverse cholesterol transport and thus plays an important role in the metabolism of lipids and lipoproteins, meaning that it can affect the development of lipid metabolism disorders. Significantly elevated serum apoM levels are detected in patients with hyperlipidemia...
September 6, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28871336/zoledronate-dysregulates-fatty-acid-metabolism-in-renal-tubular-epithelial-cells-to-induce-nephrotoxicity
#8
Lili Cheng, Mengmeng Ge, Zhou Lan, Zhilong Ma, Wenna Chi, Wenhua Kuang, Kun Sun, Xinbin Zhao, Ye Liu, Yaqian Feng, Yuedong Huang, Maoguo Luo, Liping Li, Bin Zhang, Xiaoyu Hu, Lina Xu, Xiaohui Liu, Yi Huo, Haiteng Deng, Jinliang Yang, Qiaoran Xi, Yonghui Zhang, Julie A Siegenthaler, Ligong Chen
Zoledronate is a bisphosphonate that is widely used in the treatment of metabolic bone diseases. However, zoledronate induces significant nephrotoxicity associated with acute tubular necrosis and renal fibrosis when administered intravenously. There is speculation that zoledronate-induced nephrotoxicity may result from its pharmacological activity as an inhibitor of the mevalonate pathway but the molecular mechanisms are not fully understood. In this report, human proximal tubular HK-2 cells and mouse models were combined to dissect the molecular pathways underlying nephropathy caused by zoledronate treatments...
September 4, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28870804/high-glucose-instigates-tubulointerstitial-injury-by-stimulating-hetero-dimerization-of-adiponectin-and-angiotensin-ii-receptors
#9
Dongqing Zha, Huaiyan Cheng, Weiwei Li, Yizhe Wu, Xiaoning Li, Lian Zhang, Ying-Hong Feng, Xiaoyan Wu
Abnormal expression and dysfunction of adiponectin and the cognate receptors are involved in diabetes and diabetic kidney disease (DKD), whereas angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) alleviate diabetic albuminuria and prevent development of DKD through upregulation of adiponectin expression. Here we report that high glucose stimulates expression of angiotensin II (AngII) receptors (AT1 and AT2) in renal proximal tubular epithelial cells (NRK-52E). These receptors underwent hetero-dimerization with adiponectin receptor AdipoR1 and AdipoR2, respectively...
September 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28867961/potential-immunotoxic-effects-of-trichloroethylene-induced-iv-allergic-reaction-in-renal-impairment
#10
Jun-Feng Yu, Yan-Yan Feng, Xiao-Feng Shen
Trichloroethylene (TCE) is known to induce allergic contact dermatitis and subsequent occupational medicamentosa-like dermatitis (OMLD) with multi-system injuries, including liver, kidney, and skin injuries. However, the mechanisms underlying immune system dysfunction that result in organ injury have not yet been clearly elucidated. In the present study, we measured the levels of secreted cytokines by effect or T cells in TCE-treated guinea pigs to better understand the contribution of allergic disorders in renal injuries...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28859984/epstein-barr-virus-encoded-latent-membrane-protein-1-induces-epithelial-to-mesenchymal-transition-by-inducing-v-set-ig-domain-containing-4-vsig4-expression-via-nf-kb-in-renal-tubular-epithelial-hk-2%C3%A2-cells
#11
Seung-Mi Kim, Se Won Oh, Sang Hyun Park, Dae Young Hur, Seung-Woo Hong, Sang Youb Han
The epithelial to mesenchymal transition (EMT), a hallmark of chronic kidney disease, is a key event in the conversion from tubular epithelial cells to myofibroblasts in renal fibrosis. Epstein-Barr virus (EBV) is a γ-herpes oncovirus associated with chronic kidney disease. However, the relationship between EBV and the EMT process in renal tubular epithelial cells is not well understood. Among EBV-latent genes, EBV-encoded latent membrane protein 1 (LMP1) induces EMT by regulating a variety of molecules in EBV-induced oncogenic transformation...
August 30, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28858401/histopathology-of-middle-east-respiratory-syndrome-coronovirus-mers-cov-infection-clinicopathological-and-ultrastructural-study
#12
Khaled O Alsaad, Ali H Hajeer, Mohammed Al Balwi, Mohammed Al Moaiqel, Nourah Al Oudah, Abdulaziz Al Ajlan, Sameera AlJohani, Sami Alsolamy, Giamal E Gmati, Hanan Balkhy, Hamdan H Al-Jahdali, Salim A Baharoon, Yaseen M Arabi
AIMS: The pathogenesis, viral localization and histopathological features of Middle East Respiratory Syndrome - Coronavirus (MERS-CoV) in human are not sufficiently described. The aims of this study were to explore and define the spectrum of histological and ultrastructural pathological changes affecting various organs in a patient with MERS-CoV infection and represent a base of MERS-CoV histopathology. METHODS AND RESULTS: We analyzed the postmortem histopathological findings and investigated viral particles localization in the pulmonary and extra-pulmonary tissue by transmission electron microscopic examination in a 33-year-old male patient of T-cell lymphoma, who acquired MERS-CoV infection...
August 31, 2017: Histopathology
https://www.readbyqxmd.com/read/28852907/functional-role-of-suv39h1-in-human-renal-tubular-epithelial-cells-under-high-glucose-ambiance
#13
Jiayi Wang, Wenzhe Yan, Xiaofei Peng, Yafeng Jiang, Liyu He, Youming Peng, Xian Chen, Muyao Ye, Hui Zhuo
SUV39H1, the histone methyltransferase (HMTase) of histone H3 lysine 9 trimethylation (H3K9me3), is a known transcriptional repressor of inflammatory genes. The effect of SUV39H1 on inflammatory gene promoters under high-glucose stimulation in vascular smooth muscle cells (VSMCs), macrophages, and cardiomyocytes has been studied, but how SUV39H1 functions in renal tubules under diabetic conditions is unclear. Renal biopsy specimens of ten diabetic nephropathy (DN) subjects and seven non-DN minimal change diseases (MCD) subjects were collected...
August 29, 2017: Inflammation
https://www.readbyqxmd.com/read/28846887/attenuation-of-cyclosporine-a-induced-nephrotoxicity-by-schisandrin-b-through-suppression-of-oxidative-stress-apoptosis-and-autophagy
#14
Qiao Lai, Zhengzhong Luo, Chunying Wu, Sisi Lai, Hanmei Wei, Tongming Li, Qing Wang, Yang Yu
Cyclosporine A (CsA) is a potent immunosuppressive agent whose clinical usage is limited by nephrotoxicity. Schisandrin B (SchB), isolated from the fruit of Schisandra chinensis, is a natural compound with multiple pharmacological activities that has been shown to attenuate organ injury caused by CsA. Hence, the primary objective of the current study was to evaluate whether SchB has a cytoprotective effect on CsA-induced nephrotoxicity in human proximal tubular epithelial cell line (HK-2). This study demonstrated that pre-incubation of HK-2 cells with 2...
August 25, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28843710/renal-collision-tumor-composed-of-oncocytoma-and-mucinous-tubular-and-spindle-cell-carcinoma-case-report-of-an-unprecedented-entity
#15
Komal Arora, Ross Miller, Seema Mullick, Steven Shen, Alberto G Ayala, Jae Y Ro
Primary renal collision tumors composed of two histologically distinct components are rare with only isolated case reports in the medical literature. Oncocytoma is a benign renal neoplasm, which is thought to originate from distal tubular epithelial cells. Mucinous tubular and spindle cell carcinoma (MTSCC) of kidney is a rare, relatively recently described renal neoplasm that was first included in the 2004 World Health Organization RCC classification as a distinct entity. Current studies suggest the tumor originates from the proximal nephron, although it is still controversial...
August 23, 2017: Human Pathology
https://www.readbyqxmd.com/read/28831192/zika-virus-infects-renal-proximal-tubular-epithelial-cells-with-prolonged-persistency-and-cytopathic-effects
#16
Jian Chen, Yi-Feng Yang, Jun Chen, Xiaohui Zhou, Zhaoguang Dong, Tianyue Chen, Yu Yang, Peng Zou, Biao Jiang, Yunwen Hu, Lu Lu, Xiaoyan Zhang, Jia Liu, Jianqing Xu, Tongyu Zhu
Zika virus (ZIKV) infection can cause fetal developmental abnormalities and Guillain-Barré syndrome in adults. Although progress has been made in understanding the link between ZIKV infection and microcephaly, the pathology of ZIKV, particularly the viral reservoirs in human, remains poorly understood. Several studies have shown that compared to serum samples, patients' urine samples often have a longer duration of ZIKV persistency and higher viral load. This finding suggests that an independent viral reservoir may exist in the human urinary system...
August 23, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28819999/high-glucose-induces-hgf-independent-activation-of-met-receptor-in-human-renal-tubular-epithelium
#17
Lucia Mesarosova, Peter Ochodnicky, Jaklien C Leemans, Sandrine Florquin, Peter Krenek, Jan Klimas
CONTEXT: The role of hepatocyte growth factor (HGF) in diabetic kidney damage remains controversial. OBJECTIVE: To test the hypothesis that high glucose levels activate pathways related to HGF and its receptor Met and that this could participate in glucose-induced renal cell damage. MATERIALS AND METHODS: HK2 cells, a human proximal tubule epithelial cell line, were stimulated with high glucose for 48 hours. Levels of pMet/Met, pEGFR/EGFR, pSTAT3/STAT3, pAkt/Akt and pERK1/2/ERK1/2 were studied by immunoblotting...
August 18, 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28817830/microrna-200a-inhibits-transforming-growth-factor-%C3%AE-1-induced-proximal-tubular-epithelial-mesenchymal-transition-by-targeting-%C3%AE-catenin
#18
Yi Gong, Zhexue Qin, Baoshang Zhou, Hua Chen, Zhengmin Shi, Jing Zhang
BACKGROUND: The epithelial-mesenchymal transition (EMT) is a crucial event in the development of renal interstitial fibrosis (RIF). A growing body of evidence indicates that β-catenin plays an important role in various types of fibrosis. Although members of the microRNA (miRNA)-200 family have been suggested to suppress EMT in cancer and fibrosis, the function of miRNA-200a in regulating the progression of RIF is unknown. We speculate that miRNA-200a may hinder this progression through the suppression of β-catenin...
August 18, 2017: Nephron
https://www.readbyqxmd.com/read/28815470/alterations-in-scai-expression-during-cell-plasticity-fibrosis-and-cancer
#19
Ákos Gasparics, Gábor Kökény, Attila Fintha, Rita Bencs, Miklós M Mózes, Emese Irma Ágoston, Anna Buday, Zoltán Ivics, Péter Hamar, Balázs Győrffy, László Rosivall, Attila Sebe
Suppressor of cancer cell invasion (SCAI) has been originally characterized as a tumor suppressor inhibiting metastasis in different human cancer cells, and it has been suggested that SCAI expression declines in tumors. The expression patterns and role of SCAI during physiological and pathophysiological processes is still poorly understood. Earlier we demonstrated that SCAI is regulating the epithelial-mesenchymal transition of proximal tubular epithelial cells, it is downregulated during renal fibrosis and it is overexpressed in Wilms' tumors...
August 16, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28814511/targeting-phospholipase-d4-attenuates-kidney-fibrosis
#20
Priyanka Trivedi, Ramya K Kumar, Ashwin Iyer, Sarah Boswell, Casimiro Gerarduzzi, Vivekkumar P Dadhania, Zach Herbert, Nikita Joshi, James P Luyendyk, Benjamin D Humphreys, Vishal S Vaidya
Phospholipase D4 (PLD4), a single-pass transmembrane glycoprotein, is among the most highly upregulated genes in murine kidneys subjected to chronic progressive fibrosis, but the function of PLD4 in this process is unknown. Here, we found PLD4 to be overexpressed in the proximal and distal tubular epithelial cells of murine and human kidneys after fibrosis. Genetic silencing of PLD4, either globally or conditionally in proximal tubular epithelial cells, protected mice from the development of fibrosis. Mechanistically, global knockout of PLD4 modulated innate and adaptive immune responses and attenuated the upregulation of the TGF-β signaling pathway and α1-antitrypsin protein (a serine protease inhibitor) expression and downregulation of neutrophil elastase (NE) expression induced by obstructive injury...
August 16, 2017: Journal of the American Society of Nephrology: JASN
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