keyword
https://read.qxmd.com/read/38245792/high-and-selective-cytotoxicity-of-ex-vivo-expanded-allogeneic-human-natural-killer-cells-from-peripheral-blood-against-bladder-cancer-implications-for-natural-killer-cell-instillation-after-transurethral-resection-of-bladder-tumor
#1
JOURNAL ARTICLE
Fangming Wang, Gang Zhang, Tianli Xu, Jianlin Ma, Jing Wang, Shuai Liu, Yuzhe Tang, Song Jin, Jianxing Li, Nianzeng Xing
BACKGROUND: Non-muscle-invasive bladder cancer (NMIBC) is treated with transurethral resection of bladder tumor (TURBT) followed by intravesical instillation of chemotherapy or Bacillus Calmette-Guérin therapy. However, these treatments have a high recurrence rate and side effects, emphasizing the need for alternative instillations. Previously, we revealed that expanded allogeneic human natural killer (NK) cells from peripheral blood are a promising cellular therapy for prostate cancer...
January 20, 2024: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/37998322/porcine-ul-16-binding-protein-1-is-not-a-functional-ligand-for-the-human-natural-killer-cell-activating-receptor-nkg2d
#2
JOURNAL ARTICLE
Kevin J Lopez, John Paul Spence, Wei Li, Wenjun Zhang, Barry Wei, Arthur A Cross-Najafi, James R Butler, David K C Cooper, Burcin Ekser, Ping Li
Natural killer (NK) cells play a vital role in xenotransplantation rejection. One approach to induce NK cell immune tolerance is to prevent the NK cell-mediated direct killing of porcine cells by targeting the interaction of the activating receptor NKG2D and its ligands. However, the identity of porcine ligands for the human NKG2D receptor has remained elusive. Previous studies on porcine UL-16 binding protein 1 (pULBP-1) as a ligand for human NKG2D have yielded contradictory results. The goal of the present study was to clarify the role of pULBP-1 in the immune response and its interaction with human NKG2D receptor...
November 7, 2023: Cells
https://read.qxmd.com/read/37774496/upregulation-of-the-nkg2d-ligand-ulbp2-by-jc-polyomavirus-infection-promotes-immune-recognition-by-natural-killer-cells
#3
JOURNAL ARTICLE
Stephanie Jost, Jenny Ahn, Sarah Chen, Taylor Yoder, Kayitare Eunice Gikundiro, Esther Lee, Simon B Gressens, Kyle Kroll, Melissa Craemer, G Campbell Kaynor, Michelle Lifton, C Sabrina Tan
BACKGROUND: JC polyomavirus(JCPyV) causes progressive multifocal leukoencephalopathy(PML), a potentially fatal complication of severe immune suppression with no effective treatment. Natural killer (NK) cells play critical roles in defense against viral infections, yet NK cell response to JCPyV infection remains unexplored. METHODS: NK and T cell responses against the JCPyV VP1 were compared using intracellular cytokine staining (ICS) upon stimulation with peptide pools...
September 29, 2023: Journal of Infectious Diseases
https://read.qxmd.com/read/37714550/complement-proteins-l-ficolin-and-m-ficolin-are-increased-in-axial-spondyloarthritis-patients-and-decrease-after-tnf-inhibitor-treatment
#4
JOURNAL ARTICLE
Clara Elbæk Mistegaard, Anne Troldborg, Annette Hansen, Steffen Thiel, Anne Grethe Jurik, Rosa M Kiil, Alice A Christiansen, Berit Schiøttz-Christensen, Oliver Hendricks, Susanne Juhl Pedersen, Inge Juul Sørensen, Mikkel Østergaard, Anne Gitte Loft
OBJECTIVE: We have previously reported elevated levels of the complement lectin pathway proteins L-ficolin and H-ficolin in axial spondyloarthritis (axSpA) patients compared with healthy controls. The aim of this study was to investigate these biomarkers in a cross-sectional cohort of patients suffering from low back pain (LBP). Furthermore, we aimed to investigate changes in lectin pathway protein levels after initiation of adalimumab (TNF-inhibitor) in a longitudinal cohort of axSpA patients...
September 15, 2023: Journal of Rheumatology
https://read.qxmd.com/read/37626965/the-role-and-regulation-of-the-nkg2d-nkg2d-ligand-system-in-cancer
#5
REVIEW
Ge Tan, Katelyn M Spillane, John Maher
The family of human NKG2D ligands (NKG2DL) consists of eight stress-induced molecules. Over 80% of human cancers express these ligands on the surface of tumour cells and/or associated stromal elements. In mice, NKG2D deficiency increases susceptibility to some types of cancer, implicating this system in immune surveillance for malignancy. However, NKG2DL can also be shed, released via exosomes and trapped intracellularly, leading to immunosuppressive effects. Moreover, NKG2D can enhance chronic inflammatory processes which themselves can increase cancer risk and progression...
August 2, 2023: Biology
https://read.qxmd.com/read/37565867/involvement-of-klrk1-in-immune-infiltration-of-head-and-neck-squamous-cell-carcinoma-correlates-with-favorable-prognosis
#6
JOURNAL ARTICLE
Haosheng Tan, Huaiyu Yang, Jiaxin Qian, Shaoyan Liu, Dangui Yan, Liyuan Wei, Wensheng Liu
Head and neck squamous cell carcinoma (HNSCC) is a malignancy commonly found in the head and neck region, with a low 5-year survival rate. Although immunotherapy has made significant progress, its efficacy in HNSCC treatment remains unsatisfactory. Killer cell lectin-like receptor K1 (KLRK1), a marker highly expressed in immune cells, can bind to its ligands expressed by cancer cells to exert its antitumor effect. However, the role of KLRK1 in HNSCC has yet to be studied extensively. This study aimed to explore the involvement of KLRK1 in immune infiltration of HNSCC and its correlation with prognosis...
August 11, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37509938/benign-and-malignant-breast-tumor-classification-in-ultrasound-and-mammography-images-via-fusion-of-deep-learning-and-handcraft-features
#7
JOURNAL ARTICLE
Clara Cruz-Ramos, Oscar García-Avila, Jose-Agustin Almaraz-Damian, Volodymyr Ponomaryov, Rogelio Reyes-Reyes, Sergiy Sadovnychiy
Breast cancer is a disease that affects women in different countries around the world. The real cause of breast cancer is particularly challenging to determine, and early detection of the disease is necessary for reducing the death rate, due to the high risks associated with breast cancer. Treatment in the early period can increase the life expectancy and quality of life for women. CAD (Computer Aided Diagnostic) systems can perform the diagnosis of the benign and malignant lesions of breast cancer using technologies and tools based on image processing, helping specialist doctors to obtain a more precise point of view with fewer processes when making their diagnosis by giving a second opinion...
June 28, 2023: Entropy
https://read.qxmd.com/read/37435613/the-effect-of-sevoflurane-on-metalloproteinase-and-natural-killer-group2-member-d-nkg2d-ligand-expression-and-natural-killer-cell-mediated-cytotoxicity-in-breast-cancer-an-in-vitro-study
#8
JOURNAL ARTICLE
Hyae Jin Kim, Soeun Jeon, Hyeon Jeong Lee, Jaeho Bae, Hyun-Su Ri, Jeong-Min Hong, Sung In Paek, Seul Ki Kwon, Jae Rin Kim, Seungbin Park, Eun-Jung Yun
BACKGROUND: We investigated the impacts of sevoflurane exposure on matrix metalloproteinase (MMP) expression, natural killer group 2, member D (NKG2D) ligands (UL16-binding proteins [ULBP] 1-3, and major histocompatibility complex class I chain-related molecules [MIC] A/B) expression and ablation, and natural killer (NK) cell-mediated cytotoxicity in breast cancer cells. METHODS: Three human breast cancer cell lines (MCF-7, MDA-MB-453, and HCC-70) were incubated with 0 (control), 600 (S6), or 1200 μM (S12) sevoflurane for 4 h...
July 12, 2023: Korean Journal of Anesthesiology
https://read.qxmd.com/read/37298418/cross-dressing-of-multiple-myeloma-cells-mediated-by-extracellular-vesicles-conveying-mic-and-ulbp-ligands-promotes-nk-cell-killing
#9
JOURNAL ARTICLE
Elisabetta Vulpis, Luisa Loconte, Chiara Cassone, Fabrizio Antonangeli, Giulio Caracciolo, Laura Masuelli, Francesca Fazio, Maria Teresa Petrucci, Cinzia Fionda, Alessandra Soriani, Cristina Cerboni, Marco Cippitelli, Angela Santoni, Alessandra Zingoni
Natural Killer (NK) cells are innate cytotoxic lymphoid cells that play a crucial role in cancer immunosurveillance. NKG2D is an activating receptor that binds to MIC and ULBP molecules typically induced on damaged, transformed, or infected cells. The secretion of NKG2D ligands (NKG2DLs) through protease-mediated cleavage or in an extracellular vesicle (EV) is a mode to control their cell surface expression and a mechanism used by cancer cells to evade NKG2D-mediated immunosurveillance. EVs are emerging as important players in mediating cell-to-cell communication due to their ability to transfer biological material to acceptor cells...
May 30, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36862260/stem-cell-assisted-enzyme-prodrug-therapy-makes-drug-resistant-ovarian-cancer-cells-vulnerable-to-natural-killer-cells-through-upregulation-of-nkg2d-ligands
#10
JOURNAL ARTICLE
Geng Li, Shahryar Khoshtinat Nikkhoi, Arash Hatefi
Cancer stem-like cells (CSCs) are believed to be responsible for cancer recurrence and metastasis. Therefore, a therapeutic approach is needed to eliminate both rapidly proliferating differentiated cancer cells and slow-growing drug-resistant CSCs. Using established ovarian cancer cells lines as well as ovarian cancer cells isolated from a patient with high-grade drug-resistant ovarian carcinoma, we demonstrate that ovarian CSCs consistently express lower levels of NKG2D ligands (MICA/B and ULBPs) on their surfaces, a mechanism by which they evade natural killer (NK) cells' surveillance...
March 2, 2023: Medical Oncology
https://read.qxmd.com/read/36569955/editorial-the-interaction-of-nkg2d-and-its-ligands-in-health-and-diseases
#11
EDITORIAL
Silvana Gaudieri, Hugh T Reyburn, Mar Vales-Gomez, Chanvit Leelayuwat
No abstract text is available yet for this article.
2022: Frontiers in Immunology
https://read.qxmd.com/read/36338147/human-allogenic-%C3%AE-%C3%AE-t-cells-kill-patient-derived-glioblastoma-cells-expressing-high-levels-of-dnam-1-ligands
#12
JOURNAL ARTICLE
Haeyoun Choi, Yunkyung Lee, Soon A Park, Ji Hyeon Lee, Junseong Park, Jang Hyun Park, Heung Kyu Lee, Tai-Gyu Kim, Sin-Soo Jeun, Stephen Ahn
Adoptive transfer of γδ T cells is a novel immunotherapeutic approach to glioblastoma. Few recent studies have shown the efficacy of γδ T cells against glioblastoma, but no previous studies have identified the ligand-receptor interactions between γδ T cells and glioblastoma cells. Here, we identify those ligand-receptor interactions and provide a basis for using γδ T cells to treat glioblastoma. Vγ9Vδ2 T cells were generated from peripheral blood mononuclear cells of healthy donors using artificial antigen presenting cells...
2022: Oncoimmunology
https://read.qxmd.com/read/36175895/enhanced-natural-killer-cell-anti-tumor-activity-with-nanoparticles-mediated-ferroptosis-and-potential-therapeutic-application-in-prostate-cancer
#13
JOURNAL ARTICLE
Kwang-Soo Kim, Bongseo Choi, Hyunjun Choi, Min Jun Ko, Dong-Hwan Kim, Dong-Hyun Kim
Ferroptosis provides an opportunity to overcome the cancer cell therapeutic resistance and modulate the immune system. Here an interaction between ferroptosis of cancer cells and natural killer (NK) cells was investigated with a clinical grade iron oxide nanoparticle (ferumoxytol) for potential synergistic anti-cancer effect of ferroptosis and NK cell therapy in prostate cancer. When ferumoxytol mediated ferroptosis of cancer cells was combined with NK cells, the NK cells' cytotoxic function was increased. Observed ferroptosis mediated NK cell activation was also confirmed with IFN-γ secretion and lytic degranulation...
September 29, 2022: Journal of Nanobiotechnology
https://read.qxmd.com/read/36142281/integrated-antitumor-activities-of-cellular-immunotherapy-with-cik-lymphocytes-and-interferons-against-kit-pdgfra-wild-type-gist
#14
JOURNAL ARTICLE
Erika Fiorino, Alessandra Merlini, Lorenzo D'Ambrosio, Ilaria Cerviere, Enrico Berrino, Caterina Marchiò, Lidia Giraudo, Marco Basiricò, Annamaria Massa, Chiara Donini, Valeria Leuci, Ramona Rotolo, Federica Galvagno, Letizia Vitali, Alessia Proment, Soldano Ferrone, Alberto Pisacane, Ymera Pignochino, Massimo Aglietta, Giovanni Grignani, Giulia Mesiano, Dario Sangiolo
Gastrointestinal stromal tumors (GISTs) are rare, mesenchymal tumors of the gastrointestinal tract, characterized by either KIT or PDGFRA mutation in about 85% of cases. KIT/PDGFRA wild type gastrointestinal stromal tumors (wtGIST) account for the remaining 15% of GIST and represent an unmet medical need: their prevalence and potential medical vulnerabilities are not completely defined, and effective therapeutic strategies are still lacking. In this study we set a patient-derived preclinical model of wtGIST to investigate their phenotypic features, along with their susceptibility to cellular immunotherapy with cytokine-induced killer lymphocytes (CIK) and interferons (IFN)...
September 8, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36073504/mmp-2-inhibitor-mediated-tumor-microenvironment-regulation-using-a-sequentially-released-bio-nanosystem-for-enhanced-cancer-photo-immunotherapy
#15
JOURNAL ARTICLE
Huifang Liu, Dongqin Lei, Jiong Li, Jing Xin, Luwei Zhang, Lei Fu, Jing Wang, Weihui Zeng, Cuiping Yao, Zhenxi Zhang, Sijia Wang
Combining photodynamic therapy (PDT) with natural killer (NK) cell-based immunotherapy has shown great potential against cancers, but the shedding of NK group 2, member D ligands (NKG2DLs) on tumor cells inhibited NK cell activation in the tumor microenvironment. Herein, we assembled microenvironment-/light-responsive bio-nanosystems (MLRNs) consisting of SB-3CT-containing β-cyclodextrins (β-CDs) and photosensitizer-loaded liposomes, in which SB-3CT was considered to remodel the tumor microenvironment. β-CDs and liposomes were linked by metalloproteinase 2 (MMP-2) responsive peptides, enabling sequential release of SB-3CT and chlorin e6 triggered by the MMP-2-abundant tumor microenvironment and 660 nm laser irradiation, respectively...
September 8, 2022: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/35970825/circular-ezh2-encoded-ezh2-92aa-mediates-immune-evasion-in-glioblastoma-via-inhibition-of-surface-nkg2d-ligands
#16
JOURNAL ARTICLE
Jian Zhong, Xuesong Yang, Junju Chen, Kejun He, Xinya Gao, Xujia Wu, Maolei Zhang, Huangkai Zhou, Feizhe Xiao, Lele An, Xiuxing Wang, Yu Shi, Nu Zhang
Glioblastoma (GBM) is a highly aggressive primary brain tumour and is resistant to nearly all available treatments, including natural killer (NK) cell immunotherapy. However, the factors mediating NK cell evasion in GBM remain largely unclear. Here, we report that EZH2-92aa, a protein encoded by circular EZH2, is overexpressed in GBM and induces the immune evasion of GBM stem cells (GSCs) from NK cells. Positively regulated by DEAD-box helicase 3 (DDX3), EZH2-92aa directly binds the major histocompatibility complex class I polypeptide-related sequence A/B (MICA/B) promoters and represses their transcription; it also indirectly represses UL16-binding protein (ULBP) transcription by stabilizing EZH2...
August 15, 2022: Nature Communications
https://read.qxmd.com/read/35803129/antioxidant-nutrients-can-increase-high-dose-methotrexate-efficacy-in-4t1-breast-tumor-model-an-experimental-study-on-vitamin-e-succinate-and-methyl-selenic-acid
#17
JOURNAL ARTICLE
Meisam Barati, Mahdi Shabani, Masoumeh Jabbari, Vahid Khaki Bakhtiarvand, Payman Nikmehr, Houssein Ahmadi, Mohammad Esmaeil Akbari, Sayed Hossein Davoodi
BACKGROUND: We aimed to evaluate the anti-cancer and immune system enhancing properties of Vitamin E succinate (VES) and methylselenic acid (MSA) administration on 4T1 breast tumor model under high-dose methotrexate (HDMTX) therapy and folinic acid (FA) rescue. METHODS: Thirty six 4T1 mammary carcinoma bearing mice were randomly divided into six groups: control (untreated; n = 6), treatment-1 (T1 group; HDMTX; n = 6), T2 (T1 + FA; n = 6), T3 (T2 + MSA; n = 6), T4 (T2 + VES; n = 6) and T5 (T3 + VES; n = 6)...
September 2022: International Immunopharmacology
https://read.qxmd.com/read/35780757/expressional-regulation-of-nkg2dls-is-associated-with-the-tumor-development-and-shortened-overall-survival-in-lung-adenocarcinoma
#18
JOURNAL ARTICLE
Burak Kucuk, Ercan Cacan
Natural killer group 2D ligands (NKG2DLs) are expressed on tumor cells as a ligand for Natural killer group 2D (NKG2D) receptors. NKG2DLs interact with NKG2D to induce immune cell-mediated cytotoxicity for eliminating tumors. Studies demonstrated that tumor cells can reduce NKG2DLs' expression to escape from anti-tumor immunity, leading to an aggressive cancer phenotype and poor prognosis in some cancers. However, these studies are limited and there is no comprehensive work on the regulation of NKG2DLs in lung adenocarcinoma (LUAD) which is one of the deadliest cancers worldwide...
July 2022: Immunobiology
https://read.qxmd.com/read/35482216/feature-generalization-for-breast-cancer-detection-in-histopathological-images
#19
JOURNAL ARTICLE
Rik Das, Kanwalpreet Kaur, Ekta Walia
Recent period has witnessed benchmarked performance of transfer learning using deep architectures in computer-aided diagnosis (CAD) of breast cancer. In this perspective, the pre-trained neural network needs to be fine-tuned with relevant data to extract useful features from the dataset. However, in addition to the computational overhead, it suffers the curse of overfitting in case of feature extraction from smaller datasets. Handcrafted feature extraction techniques as well as feature extraction using pre-trained deep networks come into rescue in aforementioned situation and have proved to be much more efficient and lightweight compared to deep architecture-based transfer learning techniques...
April 28, 2022: Interdisciplinary Sciences, Computational Life Sciences
https://read.qxmd.com/read/35364779/investigating-the-susceptibility-of-treatment-resistant-oesophageal-tumours-to-natural-killer-cell-mediated-responses
#20
JOURNAL ARTICLE
Eimear Mylod, Ellen McKenna, Maria Davern, Martin P Barr, Noel E Donlon, Becky A S Bibby, Anshul Bhardwaj, John V Reynolds, Joanne Lysaght, Stephen G Maher, Melissa J Conroy
The majority of oesophageal adenocarcinoma (OAC) patients do not respond to multimodal treatment regimens and face dismal survival rates. Natural killer (NK) cells are crucial anti-tumour immune cells, and this study investigated the susceptibility of treatment-resistant OAC cells to these potent tumour killers. Natural killer receptor (NKR) ligand expression by OE33CisP (cisplatin-sensitive) and OE33CisR (cisplatin-resistant) cells was investigated. The immunomodulatory effects of OE33CisP and OE33CisR cells on NK cell phenotype and function were assessed...
April 1, 2022: Clinical and Experimental Medicine
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