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Tongue carcinoma

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https://www.readbyqxmd.com/read/29164763/tmem207-hinders-the-tumour-suppressor-function-of-wwox-in-oral-squamous-cell-carcinoma
#1
Katsuaki Bunai, Hiroshi Okubo, Kimika Hano, Keisuke Inoue, Yusuke Kito, Chiemi Saigo, Toshiyuki Shibata, Tamotsu Takeuchi
The WW domain-containing oxidoreductase (WWOX) functions as a tumour suppressor in oral carcinogenesis. As aberrant TMEM207 expression may lead to tumour progression by hampering the tumour suppressor function of WWOX in various cancers, we explored the expression and pathobiological properties of TMEM207, focusing on the WWOX-mediated regulation of the HIF-1α pathway in oral squamous cell carcinoma (OSCC). TMEM207 immunoreactivity was detected in 40 of 90 OSCC samples but not in neighbouring non-tumorous epithelial tissues...
November 22, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29161780/assessment-of-relationship-of-abo-blood-groups-among-tobacco-induced-oral-cancer-patients-of-kanpur-population-uttar-pradesh
#2
Gayathri Ramesh, Anuradha Katiyar, Amrita Raj, Amit Kumar, Ramesh Nagarajappa, Amit Pandey
Background: The possibility of association between ABO blood groups and malignancy was first discussed by Anderson DE & Haas C. The association between blood group and oral cancer is least explored and hence this study was undertaken to evaluate relationship of ABO blood groups with an increased risk for oral cancer. Materials and method: The present study was conducted at various cancer hospitals in Kanpur. The study samples comprised 100 oral cancer patients and 50 controls with tobacco chewing habit...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29158988/a-16-gene-signature-predicting-prognosis-of-patients-with-oral-tongue-squamous-cell-carcinoma
#3
Zeting Qiu, Wei Sun, Shaowei Gao, Huaqiang Zhou, Wulin Tan, Minghui Cao, Wenqi Huang
Background: Oral tongue squamous cell carcinoma (OTSCC) is the most common subtype of oral cancer. A predictive gene signature is necessary for prognosis of OTSCC. Methods: Five microarray data sets of OTSCC from the Gene Expression Omnibus (GEO) and one data set from The Cancer Genome Atlas (TCGA) were obtained. Differentially expressed genes (DEGs) of GEO data sets were identified by integrated analysis. The DEGs associated with prognosis were screened in the TCGA data set by univariate survival analysis to obtain a gene signature...
2017: PeerJ
https://www.readbyqxmd.com/read/29158340/effects-of-black-raspberry-on-dibenzo-a-l-pyrene-diol-epoxide-induced-dna-adducts-mutagenesis-and-tumorigenesis-in-the-mouse-oral-cavity
#4
Kun-Ming Chen, Joseph B Guttenplan, Yuan-Wan Sun, Timothy Cooper, Nora Ae Shalaby, Wieslawa Kosinska, Gabrielle Benitez, Cesar Aliaga, Junjia Zhu, Jason Liao, Krishne Gowda, Shantu Amin, Gary Stoner, Karam El-Bayoumy
We previously showed that metabolic activation of the environmental and tobacco smoke constituent dibenzo[a,l]pyrene (DB[a,l]P) to its active fjord region diol epoxide (DB[a,l]PDE) is required to induce DNA damage, mutagenesis and squamous cell carcinoma (SCC) in the mouse oral cavity. In contrast to procarcinogens which were employed previously to induce SCC, DB[a,l]PDE does not require metabolic activation to exert its biological effects and thus, this study was initiated to examine, for the first time, whether black raspberry powder (BRB) inhibits post-metabolic processes such as DNA damage, mutagenesis and tumorigenesis...
November 20, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29156763/elas1-induces-apoptotic-death-in-adenocarcinoma-du145-and-squamous-cell-carcinoma-sas-cancer-cells-but-not-in-normal-kd-cells
#5
Toshihiro Uchihashi, Kaori Ota, Yusuke Yabuno, Shouichi Ohno, Kohshiro Fukushima, Yoko Naito, Mikihiko Kogo, Norikazu Yabuta, Hiroshi Nojima
We previously reported that an ELAS1 peptide containing 29 amino acids induces apoptotic death in U2OS human osteosarcoma cells following DNA double-strand break insults. Here, we show that ELAS1 also caused apoptosis in prostate adenocarcinoma DU145 cells and tongue squamous-cell carcinoma SAS cells. ELAS1 appears to be safe because it induced apoptosis only in cancer cells, not in normal KD cells. Because the effect of ELAS1 is dependent on increased stability of p53 and enhanced phosphorylation of p53-S46, we exogenously expressed wild-type p53 protein to fully promote ELAS1-mediated induction of apoptosis in SAS cells...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156735/telomerase-reverse-transcriptase-mediates-emt-through-nf-%C3%AE%C2%BAb-signaling-in-tongue-squamous-cell-carcinoma
#6
Yan Wu, Chunxiang Bian, Chunlin Zhen, Liu Liu, Zhenghong Lin, Muhammad Farrukh Nisar, Mei Wang, Jörg W Bartsch, Enyi Huang, Ping Ji, Li Yang, Yanhong Yu, Junfeng Yang, Xuemei Jiang, Julia Li Zhong
Locoregional lymph nodes metastasis in oral tongue squamous cell carcinoma represents one of important and common prognostic factors for poor clinical outcome. The human Telomerase Reverse Transcriptase (hTERT) is one of key players in cancer metastasis and stemness, but its exact function in tongue squamous cell carcinoma remains unknown. Here, we aim to understand the role of hTERT by utilizing the CRISPR/Cas9 gene editing system to deplete hTERT in the SCC-15 cell line. Functional comparison of SCC-15 control and knockout cells (hTERT(-/-)) showed that loss of hTERT suppressed cell proliferation and migration/invasion...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156523/cancer-associated-%C3%AF-broblasts-confer-cisplatin-resistance-of-tongue-cancer-via-autophagy-activation
#7
Juan-Kun Liao, Bin Zhou, Xiu-Mei Zhuang, Pei-Lin Zhuang, Da-Ming Zhang, Wei-Liang Chen
Cancer-associated fibroblasts (CAFs) play important roles in carcinogenesis and progression of tongue squamous cell carcinoma (TSCC). However, effect of CAFs on chemotherapy resistance of TSCC remains largely obscure. Here, we cultured the matched primary CAFs and normal fibroblasts (NFs) pairs and detected their roles in cisplatin sensitivity of TSCC, as well as autophagy-related protein LC3 and Beclin1 expressions. During exposure to cisplatin, TSCC with CAFs group exhibited significantly increased cell viability and IC50, but reduced apoptosis than that with NFs group...
November 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29150404/stress-hormones-concentrations-in-the-normal-microenvironment-predict-risk-for-chemically-induced-cancer-in-rats
#8
Vitor Bonetti Valente, Flávia Alves Verza, Felipe Yudi Kabeya Lopes, Joana Zafalon Ferreira, Paulo Sérgio Patto Dos Santos, Maria Lúcia Marçal Mazza Sundefeld, Éder Ricardo Biasoli, Glauco Issamu Miyahara, Ana Maria Pires Soubhia, Mariza de Andrade, Sandra Helena Penha de Oliveira, Daniel Galera Bernabé
Evidence show that stress hormones can influence cancer progression, but its role in carcinogenesis is poorly understood. In this study, we used a new method based on oral carcinogenesis model in rats to test the hypothesis that physiological levels of stress hormones in the normal tissue microenvironment would have significant predictive value for chemically induced cancer occurrence. Male Wistar rats were submitted to a tongue biopsy for measuring not-stress induced levels of norepinephrine, corticosterone, adrenocorticotropic hormone (ACTH) and brain-derived neurotrophic factor (BDNF) in the tissue before carcinogenic induction...
November 8, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29149494/inhibiting-mt2-tfe3-dependent-autophagy-enhances-melatonin-induced-apoptosis-in-tongue-squamous-cell-carcinoma
#9
Tengfei Fan, Huifeng Pi, Min Li, Zhenhu Ren, Zhijing He, Feiya Zhu, Li Tian, Manyu Tu, Jia Xie, Mengyu Liu, Yuming Li, Miduo Tan, Gaoming Li, Weijia Qing, Russel J Reiter, Zhengping Yu, Hanjiang Wu, Zhou Zhou
Autophagy modulation is a potential therapeutic strategy for tongue squamous cell carcinoma (TSCC). Melatonin possesses significant anti-carcinogenic activity. However, whether melatonin induces autophagy and its roles in cell death in TSCC are unclear. Herein, we show that melatonin induced significant apoptosis in the TSCC cell line Cal27. Apart from the induction of apoptosis, we demonstrated that melatonin-induced autophagic flux in Cal27 cells as evidenced by the formation of GFP-LC3 puncta, and the upregulation of LC3-II and downregulation of SQSTM1/P62...
November 17, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29148840/resveratrol-induces-mitochondrial-apoptosis-and-inhibits-epithelial-mesenchymal-transition-in-oral-squamous-cell-carcinoma-cells
#10
Seong-Eon Kim, Sang-Hun Shin, Jae-Yeol Lee, Chul-Hoon Kim, In-Kyo Chung, Hae-Mi Kang, Hae-Ryoun Park, Bong-Soo Park, In-Ryoung Kim
OSCC is the most common malignant cancer of the head and neck. EMT is an essential cellular process critical to the morphogenesis and homeostasis of solid tissues. It is also involved in the initial stage of cancer metastasis and invasion in which cells lose epithelial characteristics. While cancer therapy protocols such as surgery, radiation, and chemotherapy are effective and useful, the drug tolerance and toxicity of OSCC patients remain a problem. Resveratrol is mainly produced in red grape skin and exhibits anti-oxidative, anti-inflammatory, anti-proliferative, and anti-cancer properties...
November 17, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29147443/4-nitroquinoline-1-oxide-induced-tongue-and-esophagus-carcinogenesis-in-obese-and-diabetic-tsod-mice
#11
Takuji Tanaka, Kunihiro Kawabata, Shigeyuki Sugie
Background: Obesity and diabetes mellitus are associated with lifestyle-related carcinogenesis. They are also risk factors of esophageal adenocarcinoma, but there are only a few reports on association between obesity/diabetes and development of squamous cell carcinoma in the oral cavity and esophagus. In this study, we therefore aimed to determine whether obesity and diabetes affect oral and esophageal carcinogenesis using model mice of obesity and diabetes, the Tsumura Suzuki obese diabetes (TSOD) and Tsumura Suzuki non-obesity (TSNO) control mice, which were treated with 4-nitroquinoline 1-oxide (4-NQO) to produce tongue and esophageal carcinomas...
August 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29138797/activation-of-adrenergic-receptor-%C3%AE-2-promotes-tumor-progression-and-epithelial-mesenchymal-transition-in-tongue-squamous-cell-carcinoma
#12
Haichao Liu, Cheng Wang, Nan Xie, Zehang Zhuang, Xiqiang Liu, Jinsong Hou, Hongzhang Huang
Tongue squamous cell carcinoma (TSCC) is more aggressive than other cancers in the head and neck region because of its potential for metastasis. Recently, β2‑adrenergic receptor (β2‑AR) has been reported to be a potential promoter in various types of solid cancer. However, the role of β2‑AR and its effect on TSCC is not well documented. Histological staining, western blot analysis, migration and invasion assay were used. In this study, the expression of β2‑AR was increased in TSCC tissue compared with adjacent non‑cancerous epithelium...
November 9, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29137247/the-influence-of-marital-status-on-survival-in-patients-with-oral-tongue-squamous-cell-carcinoma
#13
Wei Sun, Zeting Qiu, Wulin Tan, Zhongqi Liu, Zhongxing Wang, Wenqi Huang, Minghui Cao
Marital status was found to be an independent prognostic factor for survival in several cancers. However related researches of oral tongue squamous cell carcinoma (OTSCC) are still rare. We explored the Surveillance, Epidemiology, and End Results (SEER) program and finally identified 14,194 patients with OTSCC. Kaplan-Meier analysis and multivariate Cox regression models were used to distinguish risk factors for overall survival (OS) and tumor cause-specific survival (TCSS). Widowed patients had the highest percentage of female, highest average ages and more prevalence with localized SEER Stage significantly, while patients in the single group were younger than other groups...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134466/glycogen-synthase-kinase-3%C3%AE-mediated-regulation-of-matrix-metalloproteinase-9-and-its-involvement-in-oral-squamous-cell-carcinoma-progression-and-invasion
#14
Kamdeo K Pramanik, Siddavaram Nagini, Abhay K Singh, Prajna Mishra, Tanushree Kashyap, Nidhi Nath, Manzar Alam, Ajay Rana, Rajakishore Mishra
PURPOSE: Oral squamous cell carcinoma (OSCC)-related deaths mainly result from invasion of the tumor cells into local cervical lymph nodes. It has been reported that progressive basement membrane loss promotes the metastatic and invasive capacities of OSCCs. Matrix metalloproteinase-9 (MMP-9) is known to play a central role in tumor progression and invasion. However, the role of MMP-9 in OSCC invasion has so far remained paradoxical and little is known about its regulation. Here, we aimed to assess MMP-9 expression regulation and its activation by glycogen synthase kinase-3β during human OSCC progression and invasion...
November 13, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29130787/mir-19a-and-mir-424-target-tgfbr3-to-promote-epithelial-to-mesenchymal-transition-and-migration-of-tongue-squamous-cell-carcinoma-cells
#15
Duo Li, Ke Liu, Zhiyong Li, Jian Wang, Xiaofeng Wang
Previous studies indicate that TGFBR3 (transforming growth factor type III receptor, also known as betaglycan), a novel suppressor of progression in certain cancers, is down-regulated in tongue squamous cell carcinoma (TSCC). However, the role of this factor as an upstream regulator in TSCC cells remains to be elucidated. The present study was designed to elucidate whether TGFBR3 gene expression is regulated by two microRNA molecules, miR-19a and miR-424. The study also aimed to determine if these microRNAs promote migration of CAL-27 human oral squamous cells...
November 13, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/29128262/intraoperative-imaging-during-minimally-invasive-transoral-robotic-surgery-using-near-infrared-light
#16
Nicholas Scott-Wittenborn, Ryan S Jackson
PURPOSE: The purpose of this study was to determine if the use of the FIREFLY imaging system could be an asset in transoral robotic surgery (TORS) for oropharyngeal squamous cell carcinoma (OPSCC). The system uses indocyanine green dye (ICG), which fluoresces when illuminated by near-infrared light from the Da Vinci robot. The system may improve visualization of tumor margins, highlight important vascular structures, and help identify the location of tumors and unknown primary head and neck cancers...
September 6, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29125138/detection-accuracy-for-epithelial-dysplasia-using-an-objective-autofluorescence-visualization-method-based-on-the-luminance-ratio
#17
Nanami Yamamoto, Koji Kawaguchi, Hisako Fujihara, Mitsuhiko Hasebe, Yuta Kishi, Masaaki Yasukawa, Kenichi Kumagai, Yoshiki Hamada
The autofluorescence visualization method (AVM) uses blue excitation light to assist in the diagnosis of epithelial dysplasia. It detects epithelial dysplasia as a black area, which is known as fluorescence visualization loss (FVL). In this study, we evaluated the detection accuracy for epithelial dysplasia of the tongue using the objective AVM and assessed its possible clinical utility. Seventy-nine tongue specimens clinically suspected to have leukoplakia or squamous cell carcinoma (SCC) were analyzed. First, the AVM was subjectively performed using the Visually Enhanced Lesion scope (VELscope), and the iodine-staining method was then performed...
November 10, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/29117785/notch1-regulates-tongue-cancer-cells-proliferation-apoptosis-and-invasion
#18
Rui-Huan Gan, Hua Wei, Jing Xie, Dan-Ping Zheng, Er-Ling Luo, Xiao-Yu Huang, Jian Xie, Yong Zhao, Lin-Can Ding, Bo-Hua Su, Li-Song Lin, Da-Li Zheng, You-Guang Lu
OBJECTIVES: Notch1 regulates tumor biology in a complex, context-dependent manner. The roles of Notch1 in tongue cancer are still controversial. The aim of this study is to investigate the roles of Notch1 in tongue cancer. MATERIALS AND METHODS: The expression of Notch1 was tested between tongue cancer and normal samples by using immunohistochemistry. Tongue cancer cells were transfected with siRNA or plasmid, respectively. Cell proliferation, apoptosis, migration and invasion ability were tested in appropriate ways...
November 8, 2017: Cell Cycle
https://www.readbyqxmd.com/read/29115421/gene-expression-profiles-and-protein%C3%A2-protein-interaction-networks-during-tongue-carcinogenesis-in-the-tumor-microenvironment
#19
Wei Sun, Zeting Qiu, Wenqi Huang, Minghui Cao
Oral tongue squamous cell carcinoma (OTSCC) has a high incidence and is associated with a high mortality rate. Studies regarding the potential molecular mechanism of OTSCC in the tumor microenvironment (TME) are required. The present study aimed to perform bioinformatic analysis to identify important nodes, clusters and functional pathways during tongue carcinogenesis in the TME. After downloading the gene expression data of GSE42780, differentially expressed genes (DEGs) among carcinoma, dysplastic and normal samples in epithelia and fibroblasts were identified using the affy and limma packages with R version 3...
October 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29113960/lesion-oxygenation-associates-with-clinical-outcomes-in-premalignant-and-early-stage-head-and-neck-tumors-treated-on-a-phase-1-trial-of-photodynamic-therapy
#20
Peter H Ahn, Jarod C Finlay, Shannon M Gallagher-Colombo, Harry Quon, Bert W O'Malley, Gregory S Weinstein, Ara Chalian, Kelly Malloy, Thomas Sollecito, Martin Greenberg, Charles B Simone, Sally McNulty, Alexander Lin, Timothy C Zhu, Virginia Livolsi, Michael Feldman, Rosemarie Mick, Keith A Cengel, Theresa M Busch
BACKGROUND: We report on a Phase 1 trial of photodynamic therapy (PDT) for superficial head and neck (H&N) lesions. Due to known oxygen dependencies of PDT, translational measurements of lesion hemoglobin oxygen saturation (StO2) and blood volume (tHb) were studied for associations with patient outcomes. METHODS: PDT with aminolevulinc acid (ALA) and escalating light doses was evaluated for high-grade dysplasia, carcinoma-in-situ, and microinvasive carcinomas of the H&N...
November 4, 2017: Photodiagnosis and Photodynamic Therapy
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