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Tongue carcinoma

M Y Sun, H J Wu
A 55-year old middle-aged male presented swelling lymph nodes in neck and mass in left tongue for three mouths. Physical examination shows a size 5 cm×5 cm mass in tongue and went over the midline. The mandibular lymph nodes were touched with moderate tenderness and little mobility in bilateral. The laboratory results, function of the kidney and heart liver, nasopharyngeal fiber area were basically normal. The result of CT and MRI shows the mass reached the lingual muscle layer and several suspected metastatic lymph nodes in neck...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Liyuan Huang, Fangfang Song, Hualing Sun, Lu Zhang, Cui Huang
Iroquois homeobox gene 5 (Irx5) is a highly conserved member of the Iroquois homeobox gene family. Members of this family play distinct and overlapping roles in normal embryonic cell patterning and development of malignancies. In this study, we observed that IRX5 was abnormally abundant in tongue squamous cell carcinoma (TSCC) tissues and cell lines. We used gain- and loss-of-function methods to overexpress and knockdown IRX5 expression in the TSCC cell line CAL27. Our results elucidated that elevated levels of IRX5 promoted proliferation, migration and invasion of TSCC cells, whereas stable or transient knockdown of IRX5 expression suppressed TSCC cell proliferation, migration and invasion...
May 15, 2018: Journal of Cellular and Molecular Medicine
Rabeia Almahmoudi, Abdelhakim Salem, Meri Sieviläinen, Elias Sundquist, Alhadi Almangush, Sanna Toppila-Salmi, Timo Paavonen, Tuula Salo, Ahmed Al-Samadi
BACKGROUND: Oral tongue squamous cell carcinoma (SCC) is characterized by early metastasis and poor prognosis. Interleukin-17F (IL-17F) plays a protective role in many tumors. However, IL-17F expression in oral tongue SCC tissue has not been investigated. METHODS: Immunostaining of 83 oral tongue SCC specimens and blinded-scoring were used to map IL-17F expression, location, and distribution. Survival curves were constructed according to Kaplan-Meier method. The Cox proportional hazard model was applied for univariate and multivariate survival analyses...
May 14, 2018: Head & Neck
Kevin Y Zhan, Patrick F Morgan, David M Neskey, Joanne J Kim, Andrew T Huang, Elizabeth Garrett-Mayer, Terry A Day
BACKGROUND: Nodal disease predicts survival in oral cavity squamous cell carcinoma (SCC). Currently, no large studies on predictors of occult nodal disease in cT1N0 oral cavity SCC exist. METHODS: The National Cancer Database (NCDB) review for cT1N0 oral cavity SCC with surgical resection and elective neck dissection (END). RESULTS: The number of patients found with occult nodal disease was 2623 (15.1%). In multivariable regression, female sex and tumor differentiation predict occult nodal disease...
May 14, 2018: Head & Neck
Feng Liao, Li Liu, En Luo, Jian Hu
PURPOSE: This study evaluated the role of anti-tumor immune response of curcumin on tongue squamous cell carcinama (TSCC). EXPERIMENTAL DESIGN: Cell lines (Cal 27, FaDu) and animal model (4NQO mice model) were uesd in this study. The MTT assay was used to detecte cell proliferation. The Western blotting, immunohistochemistry and immunofluorescence were used to examine the protein expression. The flow cytometry was performed to determine the number of Treg and MDSC...
April 30, 2018: Archives of Oral Biology
Maheer M Masood, Douglas R Farquhar, Jessica P Vanleer, Samip N Patel, Trevor G Hackman
OBJECTIVES: Depth of invasion was added to the 8th edition American Joint Committee on Cancer guidelines for T staging of HPV-negative oral cavity squamous cell carcinoma. Our aim is to determine the impact of depth of invasion on pathological variables and outcomes in low-stage tongue cancer patients. We also examine the impact of tumor thickness and tumor clinical staging for comparison. SUBJECTS AND METHODS: All clinical T1/T2 N0 HPV negative tongue squamous cell carcinoma patients who received elective neck dissections at our institution between 2000 and 2015 were included...
May 11, 2018: Oral Diseases
Dyah Listyarifah, Mikko T Nieminen, Laura K Mäkinen, Caj Haglund, Daniel Grenier, Valtteri Häyry, Dan Nordström, Marcela Hernandez, Tülay Yucel-Lindberg, Taina Tervahartiala, Mari Ainola, Timo Sorsa, Jaana Hagström
BACKGROUND: Certain periodontopathogenic bacteria have been linked to cancers. Treponema denticola (Td) is associated with severe periodontitis. Chymotrypsin-like proteinase (CTLP), a major virulence factor of Td, can degrade various host proteins and peptides, and modulate inflammatory responses. However the role of Td in the tongue carcinogenesis remains unknown. This study aimed to investigate the presence of Td-CTLP in early-stage mobile tongue squamous cell carcinoma (MTSCC) and its relation to clinical and pathological characteristics...
May 10, 2018: Journal of Oral Pathology & Medicine
Justin Wray, Robert J Amdur, Kaitlin M Christopherson, Christopher G Morris, Peter T Dziegielewski, Brian J Boyce, William M Mendenhall
OBJECTIVE: Patients with mucosal squamous cell carcinoma (SCC) of the head and neck almost always have a primary site in the base of tongue or tonsillar fossa. Lingual tonsillectomy has recently been advocated as part of the diagnostic evaluation as opposed to directed biopsies of the base of tongue and thought to possibly result in an increased likelihood or cure. The purpose of this project is to determine whether this is probable. MATERIALS AND METHODS: We reviewed the medical records of patients treated with primary radiotherapy (RT) between January 1983 and March 2013...
May 10, 2018: American Journal of Clinical Oncology
David Forner, Derek Wilke, Matthew H Rigby, Sidney Croul, Anuradha Mishra, Emad Massoud, David B Clarke, Nathan Lamond
BACKGROUND: HPV-associated OSCC (HPV-OSCC) has been determined to be a distinct disease entity from non-HPV associated OSCC. Patients affected by HPV-OSCC generally have a more favourable prognosis, with improved rates of locoregional control and survival compared with their non-HPV counterparts. Despite this, HPV-OSCC has a similar rate of distant metastases. Interestingly, recent evidence has emerged that demonstrates more frequent atypical metastasis patterns when compared to non-HPV associated disease...
May 9, 2018: Journal of Otolaryngology—Head & Neck Surgery
Michele Giuliani, Giuseppe Troiano, Massimo Cordaro, Massimo Corsalini, Gioele Gioco, Lorenzo Lo Muzio, Pamela Pignatelli, Carlo Lajolo
OBJECTIVE: The aim of this study is to systematically review the literature to determine: 1) the malignant transformation rate (TR) of Oral Lichen Planus (OLP) and its risk factors; 2) whether or not Oral Lichenoid Lesions (OLL) have a different malignant TR. MATERIALS AND METHODS: PubMed, Scopus and Web of Science were used as search engines: only observational, full-length, English language studies were investigated. PRISMA protocol was used to evaluate and present results...
May 8, 2018: Oral Diseases
Wei Chen, Kyung L Kang, Abdullah Alshaikh, Saaket Varma, Yi-Ling Lin, Ki-Hyuk Shin, Reuben Kim, Cun-Yu Wang, No-Hee Park, Katharina Walentin, Kai M Schmidt-Ott, Mo K Kang
Grainyhead-Like 2 (GRHL2) is an epithelial-specific transcription factor that regulates epithelial morphogenesis and differentiation. Prior studies suggested inverse regulation between GRHL2 and TGF-β in epithelial plasticity and potential carcinogenesis. Here, we report the role of GRHL2 in oral carcinogenesis in vivo using a novel Grhl2 knockout (KO) mouse model and the underlying mechanism involving its functional interaction with TGF-β signaling. We developed epithelial-specific Grhl2 conditional KO mice by crossing Grhl2 floxed mice with those expressing CreER driven by the K14 promoter...
May 8, 2018: Oncogenesis
Manish Mair, Deepa Nair, Sudhir Nair, Akshat Malik, Aseem Mishra, Sadhana Kannan, Saurabh Bobdey, Hitesh Singhvi, Pankaj Chaturvedi
BACKGROUND: As per TNM classification, superficial tumors with a favorable prognosis are fallaciously clubbed together with unfavorable, deeply infiltrating lesions in the same classification. METHODS: This is a retrospective study of 588 patients with treatment-naive oral tongue cancers. Binary logistic regression was used to identify predictors of nodal metastasis and extracapsular spread (ECS) using tumor volume and thickness as separate models. The C-index was generated to quantify predictive accuracy of T classification, thickness, and tumor volume for survival...
May 7, 2018: Head & Neck
Huayong Zhang, Xiaoyan Fu, Xuan Su, Ankui Yang
Increased expression of CBX3/HP1γ, a core component of heterochromatin protein 1, has recently proved to be involved in human tumorigenesis and patient prognosis. The present study aimed to investigate the expression of CBX3/HP1γ and its clinicopathological significance in primary tongue squamous cell carcinoma (TSCC). Gene expression profiles of CBX3/HP1γ in TSCC from Oncomine database were analyzed. The expression of CBX3/HP1γ at protein level was measured using immunohistochemistry (IHC). The potential associations between CBX3/HP1γ expression and multiple clinicopathological parameters were estimated using the Chi square test...
May 2018: Experimental and Therapeutic Medicine
Pooja Aggarwal, Chitrapriya Saxena, Arun Kumar, Vijay Wadhwan
Basaloid squamous cell carcinoma is a rare distinct histologic variant of squamous cell carcinoma of the head and neck region. Majority of them can be differentiated from squamous cell carcinoma by their aggressive clinical course and their histological features: the usual site of occurrence of basaloid squamous cell carcinoma is the upper areodigestive tract, floor of mouth and base of tongue. We hereby present two cases of a rare but aggressive basaloid squamous cell carcinoma, both affecting mandible.
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
C Guo, M-Q Jia, L Wang, J Jia
Primary intestinal-type adenocarcinoma (ITAC) of the tongue is a rare neoplasm. The case of a 59-year-old male with a painless mass in the dorsum of the oral tongue diagnosed as primary ITAC is reported here. The particular characteristic of the case was the patient's long-term medical history of 40years. The patient underwent resection of the tongue carcinoma through a midline approach and direct suture, with postoperative chemoradiotherapy. Immunohistochemical staining indicated that the tumour was positive for CK20 and negative for CK7...
April 30, 2018: International Journal of Oral and Maxillofacial Surgery
Yue Chen, Tian Tian, Min-Jie Mao, Wei-Ye Deng, Hao Li
BACKGROUND: Tongue squamous cell carcinoma (TSCC) is one of the most common malignancies of oral squamous cell carcinomas. Cellular retinol binding protein-1 (CRBP-1) as a carrier protein transports retinol from the liver storage site to peripheral tissue. Up-regulated expression of CRBP-1 is associated with some tumor types such as prostate cancer, breast cancer and ovarian cancer as reported, but its role in TSCC remains uncertain. METHODS: In this study, an integrated bioinformatics analysis based on the multiple cancer microarray data sets available from Oncomine database was conducted to view the differential expression of CRBP-1 between TSCC and the adjacent non-tumorous tissues...
May 2, 2018: BMC Cancer
Eric A Dik, Norbertus A Ipenburg, Peter A Kessler, Robert J J van Es, Stefan M Willems
INTRODUCTION: In oral squamous cell carcinoma (OSCC) the differentiation grade of the tumor is determined on the biopsy and the resection specimen. The relation between tumor grade, nodal metastasis and survival is debatable. The aims of this study were to determine the correlation between differentiation grade of the biopsy and the resection specimen. Furthermore, we wanted to correlate tumor differentiation grade with nodal stage and survival. PATIENTS AND METHODS: One-hundred and forty-five patients with OSCC staged as T1-2, N0 of the tongue, floor of mouth or cheek with primary resection of the tumor were examined...
April 5, 2018: Journal of Cranio-maxillo-facial Surgery
Deepa Nair, Manish Mair, Hitesh Singhvi, Aseem Mishra, Sudhir Nair, Jaiprakash Agrawal, Pankaj Chaturvedi
BACKGROUND: Controversy exists regarding the administration of adjuvant radiotherapy (RT) when perineural invasion (PNI) is the only adverse histological feature. The purpose of this study was to evaluate the impact of PNI on the survival of patients with oral cavity squamous cell carcinoma (SCC). METHODS: A retrospective study of 1524 treatment naive patients with oral cavity SCC who underwent surgery from January 2012 to March 2015 was conducted. Survival analysis was performed using Cox regression model...
April 29, 2018: Head & Neck
Corey C Foster, James M Melotek, Ryan J Brisson, Tanguy Y Seiwert, Ezra E W Cohen, Kerstin M Stenson, Elizabeth A Blair, Louis Portugal, Zhen Gooi, Nishant Agrawal, Everett E Vokes, Daniel J Haraf
OBJECTIVES: Definitive chemoradiation (CRT) for oral cavity squamous cell carcinoma (OC-SCC) is often criticized for poor efficacy or toxicity. We describe a favorable 20-year experience of primary CRT for locally-advanced OC-SCC. MATERIALS AND METHODS: Patients with locally-advanced, stage III/IV OC-SCC receiving primary concomitant CRT on protocols from 1994 to 2014 were analyzed. Chemotherapy included fluorouracil and hydroxyurea with other third agents. Radiotherapy (RT) was delivered once or twice daily to a maximum dose of 70-75 Gy...
May 2018: Oral Oncology
Jeremie Berdugo, Lester D R Thompson, Bibianna Purgina, Charles D Sturgis, Madalina Tuluc, Raja Seethala, Simion I Chiosea
The 8th edition of American Joint Committee on Cancer (AJCC 8th) staging manual incorporated depth of invasion (DOI) into pT stage of oral cavity cancer. The aim of this study was to characterize several histological findings that may complicate measurement of DOI in early conventional squamous cell carcinomas (SCC) of the oral tongue: (1) lack of or minimal residual carcinoma following biopsy; (2) positive deep margin; (3) extratumoral perineural invasion (PNI); and (4) lymphatic or vascular invasion. Conventional SCC of the oral tongue (n = 407) with the largest dimension of ≤ 4 cm and with a negative elective cervical lymph node dissection (pN0) were reviewed...
April 26, 2018: Head and Neck Pathology
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