keyword
MENU ▼
Read by QxMD icon Read
search

Tongue carcinoma

keyword
https://www.readbyqxmd.com/read/27933385/outcomes-and-prognostic-factors-for-squamous-cell-carcinoma-of-the-oral-tongue-in-young-adults-a-single-institution-case-matched-analysis
#1
Pierre Blanchard, Farid Belkhir, Stéphane Temam, Clément El Khoury, Francesca De Felice, Odile Casiraghi, Anna Patrikidou, Haitham Mirghani, Antonin Levy, Caroline Even, Philippe Gorphe, France Nguyen, François Janot, Yungan Tao
There is controversy regarding prognosis and treatment of young patients with oral cavity cancer compared to their older counterparts. We conducted a retrospective case-matched analysis of all adult patients younger than 40 years and treated at our institution for a squamous cell carcinoma of the oral cavity. Only non-metastatic adult patients (age >18) with oral tongue cancer were eventually included and matched 1:1 with patients over 40 years of age, at least 20 years older than the cases, with same T and N category and treatment period...
December 8, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27932243/inhibition-of-mtor-eif4e-by-anti-viral-drug-ribavirin-effectively-enhances-the-effects-of-paclitaxel-in-oral-tongue-squamous-cell-carcinoma
#2
Dehua Dai, Hujie Chen, Jing Tang, Yi Tang
Upregulation of eIF4E is associated with poor clinical outcome in many human cancers and represents a potential therapeutic target. However, the function of eIF4E remains unknown in oral tongue squamous cell carcinoma (OTSCC). In this work, we show that ribavirin, an anti-viral drug, effectively augments sensitivity of OTSCC cells to paclitaxel via inhibiting mTOR/eIF4E signaling pathway. Ribavirin dose-dependently inhibits proliferation and induces apoptosis in SCC-9 and CAL27 cells. Combination of ribavirin and paclitaxel are more effectively in inhibiting proliferation and inducing apoptosis in OTSCC cells...
December 5, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27930761/transoral-robotic-surgery-assisted-endoscopy-with-primary-site-detection-and-treatment-in-occult-mucosal-primaries
#3
Kyle M Hatten, Bert W O'Malley, Andres M Bur, Mihir R Patel, Christopher H Rassekh, Jason G Newman, Steven B Cannady, Ara A Chalian, Benjamin L Hodnett, Alexander Lin, John N Lukens, Roger B Cohen, Joshua M Bauml, Kathleen T Montone, Virginia A Livolsi, Gregory S Weinstein
Importance: Management of cervical lymph node metastasis without a known primary tumor is a diagnostic and treatment challenge for head and neck oncologists. Identification of the occult mucosal primary tumor minimizes the morbidity of treatment. Objective: To analyze the role of transoral robotic surgery (TORS) in facilitating the identification of a primary tumor site for patients presenting with squamous cell carcinoma of unknown primary (CUP). In addition, we assessed treatment deintensification by determining the number of patients who did not undergo definitive radiation therapy and chemotherapy...
December 8, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27930712/cantharidin-induced-oral-squamous-cell-carcinoma-cell-apoptosis-via-the-jnk-regulated-mitochondria-and-endoplasmic-reticulum-stress-related-signaling-pathways
#4
Chin-Chuan Su, Kuan-I Lee, Mu-Kuan Chen, Chun-Ying Kuo, Chih-Hsin Tang, Shing Hwa Liu
Oral cancer is a subtype of head and neck cancer which represents 2.65% of all human malignancies. Most of oral cancer is histopathologically diagnosed as oral squamous cell carcinoma (OSCC). OSCC is characterized by a high degree of local invasion and a high rate of metastasis to the cervical lymph nodes. How to prevention and treatment of OSCC is important and imperative. Here, we investigated the therapeutic effect and molecular mechanism of cantharidin, an active compound isolated from blister beetles, on OSCC in vitro...
2016: PloS One
https://www.readbyqxmd.com/read/27926795/tumour-budding-evaluated-in-biopsy-specimens-is-a-useful-predictor-of-prognosis-in-patients-with-cn0-early-stage-oral-squamous-cell-carcinoma
#5
Mai Seki, Takaaki Sano, Satoshi Yokoo, Tetsunari Oyama
AIMS: Oral squamous cell carcinoma (OSCC) prognosis depends on lymph node metastasis (LNM). We recently reported that tumour budding is a good predictive factor for LNM in squamous cell carcinoma of the tongue and floor of the mouth (FOM). Our aim was to evaluate whether tumour budding is a good prognostic factor in OSCC. METHODS AND RESULTS: We examined conventional histopathological assessment and a new factor, tumour budding, in 209 cases of OSCC in incisional biopsy specimens...
December 7, 2016: Histopathology
https://www.readbyqxmd.com/read/27926789/characterization-of-the-oropharynx-anatomy-histology-immunology-squamous-cell-carcinoma-surgical-resection
#6
REVIEW
Croix C Fossum, Ashish V Chintakuntlawar, L Price, Joaquin J Garcia
Understanding the structure and function of the oropharynx is paramount to providing excellent patient care. In clinical oncology, the oropharynx is generally divided into four distinct components: (1) base of tongue, (2) soft palate, (3) palatine tonsillar fossa, and (4) pharyngeal wall. Oropharyngeal mucosa is distinct from other mucosal surfaces in the body since it is comprised of a reticulated epithelium with a discontinuous basement membrane, also known as lymphoepithelium. This review article describes the anatomy, histology, immunology and surgical resection of the oropharynx as it relates to oncologic care...
December 7, 2016: Histopathology
https://www.readbyqxmd.com/read/27926487/egf-induces-epithelial-mesenchymal-transition-and-cancer-stem-like-cell-properties-in-human-oral-cancer-cells-via-promoting-warburg-effect
#7
Qilin Xu, Qunzhou Zhang, Yasutaka Ishida, Souren Hajjar, Xudong Tang, Haoran Shi, Chi V Dang, Anh D Le
"Warburg effect", the enhanced glycolysis or aerobic glycolysis, confers cancer cells the ability to survive and proliferate even under stressed conditions. In this study, we explored the role of epidermal growth factor (EGF) in orchestrating Warburg effect, the epithelial-mesenchymal transition (EMT) process, and the acquisition of cancer stem-like cell properties in human oral squamous cell carcinoma (OSCC) cells. Our results showed that EGF induces EMT process in OSCC cells, which correlates with the acquisition of cancer stem-like properties, including the enrichment of CD44+/CD24- population of cancer cells and an increased expression of CSC-related genes, aldehyde dehydrogenase-1 (ALDH1) and Bmi-1...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27926482/hexokinase-2-enhances-the-metastatic-potential-of-tongue-squamous-cell-carcinoma-via-the-sod2-h2o2-pathway
#8
Wei Wang, Zhonghua Liu, Luodan Zhao, Jingjing Sun, Qianting He, Wangxiang Yan, Zhiyuan Lu, Anxun Wang
The glycolytic enzyme hexokinase (HK2), which is aberrantly expressed in various types of tumours, is associated with metastasis. However, its role in the progression and metastasis of tongue squamous cell carcinoma (TSCC) remains unclear. The results of our study showed that HK2 expression is often deregulated in TSCC patients. Increased HK2 expression was associated with tumour stage, clinical stage, lymph node metastasis, but not pathological grade, and reduced overall survival. Microarray and western blotting analyses revealed increases in HK2 expression in TSCC cells with higher metastatic potential...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27925687/dna-base-excision-repair-proteins-ape-1-and-xrcc-1-are-overexpressed-in-oral-tongue-squamous-cell-carcinoma
#9
Thalita Santana, Melka Coêlho Sá, Edilmar de Moura Santos, Hébel Cavalcanti Galvão, Ricardo D Coletta, Roseana de Almeida Freitas
BACKGROUND: DNA repair systems play a critical role in protecting the human genome from damage caused by carcinogens. Modifications in DNA repair genes may be responsible for tumor development and resistance of malignant cells to chemotherapeutic agents. The major pathway for oxidative DNA damage repair is the base excision repair pathway. This study aimed to assess the immunoexpression of DNA repair proteins APE-1 and XRCC-1 and its association with clinical, histological and survival parameters in oral tongue squamous cell carcinoma in order to investigate a possible role for those proteins in tumor behavior...
December 7, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27923325/a-gingiva-derived-mesenchymal-stem-cell-laden-porcine-small-intestinal-submucosa-extracellular-matrix-construct-promotes-myomucosal-regeneration-of-the-tongue
#10
Qilin Xu, Rabie M Shanti, Qunzhou Zhang, Steven B Cannady, Bert W O'Malley, Anh D Le
In the oral cavity, the tongue is the anatomic subsite most commonly involved by invasive squamous cell carcinoma. Current treatment protocols often require significant tissue resection to achieve adequate negative margins and optimal local tumor control. Reconstruction of the tongue while preserving and/or restoring its critical vocal, chewing, and swallowing functions remains one of the major challenges in head and neck oncologic surgery. We investigated the in vitro feasibility of fabricating a novel combinatorial construct using porcine small intestinal submucosa extracellular matrix (SIS-ECM) and human gingival mesenchymal stem cells (GMSCs) as a GMSC/SIS-ECM tissue graft for the tongue reconstruction...
December 6, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27919662/squamous-cell-carcinoma-of-the-anterior-tongue-is-tumour-thickness-an-indicator-for-cervical-metastasis
#11
P Loganathan, A Sayan, D W K Hsu, S Paraneetharan, V Ilankovan
The incidence of squamous cell carcinoma (SCC) of the tongue accounts for 90% of all malignancies affecting the oral cavity and oropharynx. The distribution between the anterior and posterior tongue is equal. Nodal metastasis is dependent on various factors including tumour thickness, site, size, differentiation, and perineural and perivascular invasion. There is increasing evidence of a close correlation between tumour thickness and metastasis. A retrospective study covering the 16-year period from 2000 to 2016 was performed...
December 2, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27916172/neck-dissection-versus-watchful-waiting-in-early-squamous-cell-carcinoma-of-the-tongue-our-experience-on-127-cases
#12
Giovanni Dell'Aversana Orabona, Paola Bonavolontà, Fabio Maglitto, Marco Friscia, Giorgio Iaconetta, Luigi Califano
BACKGROUND: Early oral squamous cell carcinoma (EOSCC) represents about 90% of the oral cancers especially in older males. The etiology is multifactorial, strongly related to tobacco and alcohol abuse, but also infective agents, Human papillomaviruses (HPV16-18), genetic factors and pre-neoplastic lesions seem to be implicated. There is no consensus in the literature for the treatment of early squamous cell carcinoma of the tongue (stages I-II); both an elective neck dissection policy and a watchful-waiting policy have their proponents in the different centers...
December 2016: Surgical Oncology
https://www.readbyqxmd.com/read/27908710/prognosis-of-oral-squamous-cell-carcinoma-patients-with-level-iv-v-metastasis-an-observational-study
#13
Takumi Hasegawa, Yasuyuki Shibuya, Daisuke Takeda, Eiji Iwata, Izumi Saito, Yasumasa Kakei, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori
PURPOSE: The objectives of this study were to retrospectively describe the characteristics and outcomes of patients with oral squamous cell carcinoma (OSCC) with level IV/V metastases, and to evaluate the multivariate relationships among potential risk factors for metastasis and prognosis. MATERIALS AND METHODS: We evaluated 291 patients (178 men and 113 women; mean age, 65.9 ± 13.5 years). Clinicopathological data, time of development of level IV/V metastases, and clinical course were investigated...
October 29, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27905120/incidence-of-contralateral-bilateral-nodes-in-the-human-papillomavirus-era
#14
Andrew G Tritter, Vikas Mehta, Madeleine Samuelson, Ginger deGravelle, Xiaohui Ma, Tara Medlin-Moore, Amol Takalkar, Gloria Caldito, Cherie-Ann O Nathan
OBJECTIVES/HYPOTHESIS: HPV-positive oropharyngeal squamous cell carcinoma has a more favorable prognosis when compared to HPV-negative disease, regardless of the presence of nodal metastases. However, the importance of contralateral neck treatment based on HPV status has not been well studied. Given the historically poor prognostic implications of cervical nodal metastases, this study sought to elucidate the relationship between HPV status and contralateral/bilateral nodal metastasis in patients with oropharyngeal squamous cell carcinoma...
December 1, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27898192/reappraising-hyalinizing-clear-cell-carcinoma-a-population-based-study-with-molecular-confirmation
#15
Juan C Hernandez-Prera, Ricky Kwan, Joseph Tripodi, Simion Chiosea, Carlos Cordon-Cardo, Vesna Najfeld, Elizabeth G Demicco
BACKGROUND: Hyalinizing clear cell carcinoma (HCCC) is a rare malignancy, characterized by EWSR1-ATF1 gene fusion, whose behavior is poorly understood, as it was for many years considered a diagnosis of exclusion. METHODS: All available salivary gland carcinomas (n = 594) from our institution were reviewed. Diagnosis of HCCC was confirmed by fluorescence in situ hybridization (FISH) for EWSR1. Literature review was performed. RESULTS: We found 15 patients with HCCCs (10 women, 5 men), 13 with EWSR1 rearrangement...
November 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/27891616/human-papillomavirus-induced-oropharyngeal-cancer-in-hispanics-in-the-united-states
#16
Giovana R Thomas, Kaming Lo, Raphael Nwojo
OBJECTIVES/HYPOTHESIS: Determine disparities in survival outcome and clinical presentation between Hispanic and non-Hispanic white patients with human papillomavirus-positive oropharyngeal squamous cell carcinoma. STUDY DESIGN: Retrospective clinical research. METHODS: Clinical data on Hispanics and non-Hispanic white patients with diagnosis of human papillomavirus/p16-positive oropharyngeal squamous cell carcinoma were drawn from a tumor registry from the University of Miami Hospitals and Clinics from 2008 to 2014...
November 28, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27889695/retrospective-observational-study-of-occult-cervical-lymph-node-metastasis-in-t1n0-tongue-cancer
#17
Takayuki Imai, Ikuro Satoh, Ko Matsumoto, Yukinori Asada, Tomoko Yamazaki, Shinkichi Morita, Satoshi Saijo, Jun-Ichi Okubo, Shun Wakamori, Shigeru Saijo, Kazuto Matsuura
OBJECTIVE: Delayed neck metastasis is the most significant prognostic factor for early tongue cancer. The main strategies for controlling cervical lymph nodes in Japan are elective neck dissection or watchful waiting. Elective neck dissection offers significantly better survival, but adversely impacts patient quality of life; consequently, here we investigated how to identify high-risk patients warranting elective neck dissection. METHODS: We retrospectively evaluated 67 patients with T1N0 oral tongue squamous cell carcinoma who underwent primary treatment in our department from April 2001 to March 2015...
November 25, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27888823/investigating-kras-braf-mutation-in-oropharyngeal-squamous-cell-carcinomas-a-preliminary-study
#18
Ülkü Küçük, Ümit Bayol, Elif Usturalı Keskin, Emel Ebru Pala, İbrahim Çukurova, Mehmet Ali Çolak, Mustafa Değirmenci, Özge Özer, Altuğ Koç
OBJECTIVES: This study aims to investigate the role of KRAS/BRAF gene mutation in the pathogenesis of oropharyngeal squamous cell carcinoma (OSCC). PATIENTS AND METHODS: A total of 26 OSCC patients (23 males, 3 females; mean age 60 years; range 41 to 77 years) diagnosed between January 2003 and November 2013 were included in the study. The methods used in our study were quantitative fluorescence polymerase chain reaction for KRAS/BRAF mutation analysis. RESULTS: Ten of the tumors were located at the tongue base, 12 in the tonsil and four at the floor of mouth...
September 2016: Kulak Burun Boğaz Ihtisas Dergisi: KBB, Journal of Ear, Nose, and Throat
https://www.readbyqxmd.com/read/27888679/continuing-rise-in-oropharyngeal-cancer-in-a-high-hpv-prevalence-area-a-danish-population-based-study-from-2011-to-2014
#19
Amanda-Louise Fenger Carlander, Christian Grønhøj Larsen, David Hebbelstrup Jensen, Emilie Garnæs, Katalin Kiss, Luise Andersen, Caroline Holkmann Olsen, Maria Franzmann, Estrid Høgdall, Susanne K Kjær, Bodil Norrild, Lena Specht, Elo Andersen, Thomas van Overeem Hansen, Finn Cilius Nielsen, Christian von Buchwald
BACKGROUND: Human papillomavirus (HPV) is a critical element in the rising incidence of oropharyngeal squamous cell carcinoma (OPSCC), although whether this trend will continue, and the types of HPV responsible, are currently unknown. We previously demonstrated an increased incidence of HPV-related OPSCC in the high HPV prevalence area of Eastern Denmark from 2000 to 2010. Therefore, we investigated if the incidence for OPSCC continued to rise, the association to HPV and putative HPV-types in Eastern Denmark from 2011 to 14...
November 23, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27882233/high-dose-rate-brachytherapy-for-local-recurrent-adenoid-cystic-carcinoma-of-the-tongue-base-following-postoperative-external-beam-radiotherapy
#20
Sun Young Lee, Jung Soo Kim, Hyoung Cheol Kwon
Adenoid cystic carcinoma is a rare neoplasm commonly originating from the minor salivary glands. The clinical findings typical of this tumor include slow growth, perineural invasion and high frequency of local recurrence. In this study, a patient presented with a tongue base lesion that was treated with surgical excision and additional postoperative external beam radiotherapy. However, local recurrence occurred 8 months after radiotherapy. If recurrence occurs after radiation therapy, total glossectomy should be considered...
November 2016: Molecular and Clinical Oncology
keyword
keyword
45218
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"