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Anabolic androgenic steroids

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https://www.readbyqxmd.com/read/28054434/in-vitro-phase-i-metabolism-of-selective-estrogen-receptor-modulators-in-horse-using-ultra-high-performance-liquid-chromatography-high-resolution-mass-spectrometry
#1
Karen Y Kwok, George H M Chan, Wai Him Kwok, Jenny K Y Wong, Terence S M Wan
Selective estrogen receptor modulators (SERMs) are chemicals that possess the anti-oestrogenic activities that are banned "in" and "out" of competition by the World Anti-Doping Agency (WADA) in human sports, and by the International Federation of Horseracing Authorities (IFHA) in horseracing. SERMs can be used as performance enhancing drugs to boost the level of androgens or to compensate for the adverse effects as a result of extensive use of androgenic anabolic steroids (AASs). SERMs have indeed been abused in human sports; hence, a similar threat can be envisaged in horseracing...
January 5, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28048973/effect-of-physical-exercise-and-anabolic-steroid-treatment-on-spinal-motoneurons-and-surrounding-glia-of-wild-type-and-als-mice
#2
Roman M Kassa, Roberta Bonafede, Federico Boschi, Marina Bentivoglio, Raffaella Mariotti
Motoneuron degeneration is the hallmark of amyotrophic lateral sclerosis (ALS). The cause and predisposing factors for sporadic ALS are still unknown. Exposure to a specific environmental risk factors in subjects with a susceptibility genotype may increase the risk of the disease. The role of physical activity and the use of anabolic steroids are still debated in epidemiological studies on patients and murine models of ALS. To assess at the cellular level the role (beneficial or detrimental) of physical exercise and the use of anabolic steroid, we here investigated, in SOD1(G93A) (mSOD1) mice and wild-type littermates, changes in the ventral horn after regular exercise, treatment with the anabolic androgenic steroid 19-nortestosterone (nandrolone), and their combination, compared with matched control sedentary mice...
December 31, 2016: Brain Research
https://www.readbyqxmd.com/read/28012338/an-unusual-case-of-left-hepatectomy-for-focal-nodular-hyperplasia-fnh-linked-to-the-use-of-anabolic-androgenic-steroids-aass
#3
Angela Romano, Michele Grassia, Giuseppe Esposito, Marianna Petrillo, Modestino Pezzella, Francesco Maria Romano, Francesco Esposito, Francesco Torelli, Natale Di Martino
INTRODUCTION: Focal Nodular Hyperplasia (FNH) is the second most common benign tumor of the liver. Clinically FNH is asymptomatic and discovered incidentally . The pathogenesis is unclear; FNH is usually asymptomatic. When the tumor is large, it may be painful. Surgery is recommended only in the case of complications such as compression of adjacent organs, lesion progression with tumor size >5cm and presence of symptoms. PRESENTATION OF CASE: A 30 years old man, was evaluated during a routine visit, for diffuse abdominal pain and weight loss; Abdominal ultrasound showed no evidence of biliary obstruction but the US shows a hypoechoic, well defined focal lesion in the left liver...
November 3, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27988413/white-matter-abnormalities-in-long-term-anabolic-androgenic-steroid-users-a-pilot-study
#4
Johanna Seitz, Amanda E Lyall, Gen Kanayama, Nikos Makris, James I Hudson, Marek Kubicki, Harrison G Pope, Marc J Kaufman
Recent studies of long-term anabolic-androgenic steroid (AAS) users reported amygdala structural and functional connectivity abnormalities. We assessed white matter microstructure in the inferior-fronto-occipital fasciculus (IFOF), a major associative bundle of the amygdala network. Diffusion weighted images acquired from 9 male long-term AAS users and 8 matched controls aged 36-51 years old were processed using a standardized pipeline (Tract-Based Spatial Statistics). Group differences were examined using linear regression with adjustment for age and current testosterone level...
December 10, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27955960/the-risk-environment-of-anabolic-androgenic-steroid-users-in-the-uk-examining-motivations-practices-and-accounts-of-use
#5
Gisella Hanley Santos, Ross Coomber
BACKGROUND: The numbers using illicit anabolic-androgenic steroids are a cause of concern for those seeking to reduce health harms. Using the 'risk environment' as a conceptual framework to better comprehend how steroid users' practices and perspectives impact on health risks, this paper examines steroid user motivations, patterns of use, and the ways in which these practices are accounted for. METHODS: As part of a wider mixed-method study into performance and image enhancing drug (PIED) use and supply in one mid-sized city in South West England, qualitative interviews were undertaken with 22 steroid users...
December 7, 2016: International Journal on Drug Policy
https://www.readbyqxmd.com/read/27942448/brain-connectivity-aberrations-in-anabolic-androgenic-steroid-users
#6
Lars T Westlye, Tobias Kaufmann, Dag Alnæs, Ingunn R Hullstein, Astrid Bjørnebekk
Sustained anabolic-androgenic steroid (AAS) use has adverse behavioral consequences, including aggression, violence and impulsivity. Candidate mechanisms include disruptions of brain networks with high concentrations of androgen receptors and critically involved in emotional and cognitive regulation. Here, we tested the effects of AAS on resting-state functional brain connectivity in the largest sample of AAS-users to date. We collected resting-state functional magnetic resonance imaging (fMRI) data from 151 males engaged in heavy resistance strength training...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27937337/a-jaundiced-bodybuilder-cholestatic-hepatitis-as-side-effect-of-injectable-anabolic-androgenic-steroids
#7
Marije N Boks, Anton T Tiebosch, Laurens A van der Waaij
The use of anabolic steroids is prevalent in recreational athletes. This case report describes a young amateur bodybuilder who was referred to our outpatient clinic with jaundice and loss of appetite due to cholestatic hepatitis. Additional tests including a liver biopsy made it likely that the hepatitis was caused by the injectable anabolic steroid trenbolone enanthate. Cholestatic hepatitis may not be limited to the use of oral anabolic-androgenic steroids, as is widely assumed. Therefore, and because of other side effects, the recreational use of all forms of anabolic steroids should be discouraged...
December 12, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27930760/body-image-disorders-and-abuse-of-anabolic-androgenic-steroids-among-men
#8
Harrison G Pope, Jag H Khalsa, Shalender Bhasin
No abstract text is available yet for this article.
January 3, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27891233/effectiveness-and-implementation-of-a-community-based-prevention-programme-targeting-anabolic-androgenic-steroid-use-in-gyms-study-protocol-of-a-quasi-experimental-control-group-study
#9
Yasmina Molero, Johanna Gripenberg, Ann-Sofie Bakshi
BACKGROUND: During the past decades, concerns about increased anabolic androgenic steroid (AAS) use among recreational sportspeople have been raised, yet there is a paucity of AAS prevention efforts targeting this group. Accordingly, doping prevention efforts aimed at gyms have been recommended. The overall objective of the present project is to examine a prevention programme named 100% Pure Hard Training (100% PHT), which targets AAS use among recreational sportspeople training in gyms...
2016: BMC Sports Science, Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27890818/the-anabolic-steroid-nandrolone-alters-cannabinoid-self-administration-and-brain-cb1-receptor-density-and-function
#10
Dicky Struik, Paola Fadda, Tamara Zara, Erica Zamberletti, Tiziana Rubino, Daniela Parolaro, Walter Fratta, Liana Fattore
Clinical and pre-clinical observations indicate that anabolic-androgenic steroids can induce neurobiological changes that alter the rewarding effects of drugs of abuse. In this study, we investigated the effect of the anabolic steroid nandrolone on the rewarding properties of the cannabinoid CB1 receptor agonist WIN55,212-2 (WIN) in rats. Lister Hooded male rats were treated intramuscularly with nandrolone (15mg/kg) or vehicle for 14 consecutive days, and then allowed to self-administer WIN (12.5μg/kg/infusion) intravenously...
January 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27875951/effect-of-supraphysiological-doses-of-nandrolone-decanoate-upon-aldosterone-concentration-and-serum-na-k-levels-in-albino-mice
#11
Parmita Chowdhury, Rita Mahanta
BACKGROUND: This article is a study of adverse effects associated with the abuse of recreational drugs such as Anabolic Androgenic Steroids. Nandrolone Decanoate is one such drug often abused by athletes and bodybuilders seeking enhanced physical strength or appearance. The use of such steroids has increased dramatically over the years. OBJECTIVE: The present study was conducted to investigate the impact of nandrolone decanoate when consumed at an abused dose, upon serum aldosterone concentration in albino mice...
November 21, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27866079/multimodal-plasmonic-biosensing-nanostructures-prepared-by-dna-directed-immobilization-of-multifunctional-dna-gold-nanoparticles
#12
Nuria Tort, J-Pablo Salvador, M-Pilar Marco
Biofunctional multimodal plasmonic nanostructures suitable for multiplexed localized surface plasmon resonance (LSPR) biosensing have been created by DNA-directed immobilization (DDI) of two distinct multifunctional biohybrid gold nanoparticles. Gold nanoparticles (AuNP) of distinct sizes, and therefore showing distinct plasmon resonant peaks (RP), have been biofunctionalized and codified with two different single stranded-DNA (ssDNA) chains. One of these oligonucleotide chains has been specifically designed to direct each AuNP to a distinct location of the surface of a DNA microarray chip through specific hybridization with complementary oligonucleotide strands...
April 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27842983/a-novel-hplc-mrm-strategy-to-discover-unknown-and-long-term-metabolites-of-stanozolol-for-expanding-analytical-possibilities-in-doping-control
#13
Zhe Wang, Xinmiao Zhou, Xin Liu, Ying Dong, Jinlan Zhang
Stanozolol is one of the most commonly abused anabolic androgenic steroids (AAS) by athletes and usually detected by its parent drug and major metabolites. However, its metabolic pathway is complex, varied and individually different, it is important to characterize its overall metabolic profiles and discover new and long-term metabolites for the aims of expanding detection windows. High performance liquid chromatography coupled with triple quadrupole mass spectrometer (HPLC-MS/MS) was used to analyze the human urine after oral administration of stanozolol...
January 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27827563/analytical-strategies-to-detect-enobosarm-administration-in-bovines
#14
Nora Cesbron, Alexandre Sydor, Mylène Penot, Stéphanie Prevost, Bruno Le Bizec, Gaud Dervilly-Pinel
Selective androgen receptor modulators (SARMs) are a novel class of androgen receptor ligands. They are intended to exhibit the same kind of effects as androgenic drugs, like anabolic steroids, but be much more selective in their action, targeting particular tissues without any undesirable effects on others. While the main applications of these synthetic substances are for therapeutic purposes, they also have a high potential for misuse in veterinary practice and the sporting world. In order to guarantee the consumers with food from animal origin free from any residues of such compounds, analytical strategies are required to ensure safe food and also enable fair trade between producers...
November 9, 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27762462/the-binding-properties-of-metandienone-and-human-serum-albumin-by-comparing-with-other-five-similar-compounds
#15
Xiang Lin, Qing Wang, Xilin Peng, Hui Li
Metandienone (MET) is an exogenous anabolic androgenic steroid. The interaction between MET and human serum albumin (HSA) was investigated by molecular modeling and different optical techniques. There was no possibility of energy transfer, and the fluorescence quenching of HSA induced by MET was mainly due to the complex formation. The differences of binding ability between MET and compounds 1-5 were significantly caused by space steric hindrance. The single crystallographic data of two steroids (compounds 4 and 5) were obtained in the methanol at the first time...
October 20, 2016: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/27757350/body-builder-s-nightmare-black-market-steroid-injection-gone-wrong-a-case-report
#16
Or Friedman, Ehud Arad, Oded Ben Amotz
In the pursuit of success in sports, some athletes are not deterred by health risks associated with the (mis)use of black market preparations of dubious origin as performance-enhancing agents. Several studies published in the recent years demonstrated that anabolic-androgenic steroids, but also stimulants and growth hormones, are misused by numerous recreational athletes from all over the world. Trenbolone is an anabolic steroid routinely used in the finishing phase of beef production to improve animal performance and feed efficiency...
September 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27753588/guerilla-warfare-on-the-pancreas-a-case-of-acute-pancreatitis-from-a-supplement-known-to-contain-anabolic-androgenic-steroids
#17
Billy-Joe Liane, Charles Magee
INTRODUCTION: Performance-enhancing drugs (PEDs) are commonly consumed in the United States with high prevalence of use in athlete populations and increased use by deployed service members. Many PEDs may contain anabolic-androgenic steroids (AAS), which are legally restricted and prohibited by many agencies due to their health risk. CASE DESCRIPTION: A unique case of acute pancreatitis associated with the use of the PED "Guerilla Warfare," a labeled AAS-containing supplement, is presented...
October 2016: Military Medicine
https://www.readbyqxmd.com/read/27752030/the-effect-of-nandrolone-treatment-with-and-without-enforced-swimming-on-histological-and-biochemical-changes-in-the-heart-and-coronary-artery-of-male-rats
#18
Asghar Tofighi, Minoo Shirpoor, M H Khadem Ansari, Alireza Shirpoor, Mitra Zerehpoosh
OBJECTIVE: Chronic anabolic androgenic steroid (AAS) consumption increases incidence of cardiovascular abnormalities in athletes and mechanisms underlying those abnormalities continue to be investigated. This study examines whether nandrolone consumption induced cardiac and coronary artery wall abnormalities via oxidative stress. It was also designed to determine whether enforced swimming augmented possible cardiotoxic effects of nandrolone in rat heart. METHODS: Twenty-four male Wistar rats were divided into 3 groups: control, nandrolone, and nandrolone with enforced swimming...
October 12, 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/27726308/selective-androgen-receptor-modulators-comparative-excretion-study-of-bicalutamide-in-bovine-urine-and-faeces
#19
Dante Rojas, Gaud Dervilly-Pinel, Nora Cesbron, Mylène Penot, Alexandre Sydor, Stéphanie Prévost, Bruno Le Bizec
Besides their development for therapeutic purposes, non-steroidal selective androgen receptor modulators (non-steroidal SARMs) are also known to impact growth-associated pathways as ligands of androgenic receptors (AR). They present a potential for abuse in sports and food-producing animals as an interesting alternative to anabolic androgenic steroids (AAS). These compounds are easily available and could therefore be (mis)used in livestock production as growth promoters. To prevent such practices, dedicated analytical strategies should be developed for specific and sensitive detection of these compounds in biological matrices...
October 11, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27721739/the-diagnosis-and-manifestations-of-liver-injury-secondary-to-off-label-androgenic-anabolic-steroid-use
#20
Elena Cabb, Shanna Baltar, David Wes Powers, Karthik Mohan, Antonio Martinez, Eric Pitts
Drug-induced liver injury (DILI) presents as a broad spectrum of adverse drug reactions which can range from a mild elevation in liver enzymes to fulminant liver failure. The primary goal is to identify DILI early when the patient's liver enzymes are elevated and to discontinue the offending agent as soon as possible to prevent further injury. Herbal, dietary supplements and anabolic steroids represent a significant component of the drugs thought to cause DILI in the United States. Unlike all other drugs known to cause DILI, these drugs fall into a category of injury that is neither intrinsic nor idiosyncratic due to overlapping characteristics between the two...
May 2016: Case Reports in Gastroenterology
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