keyword
https://read.qxmd.com/read/38075204/mirna-and-lncrna-as-potential-tissue-biomarkers-in-hepatocellular-carcinoma
#21
REVIEW
Venkata Ramana Mallela, Marie Rajtmajerová, Andriy Trailin, Václav Liška, Kari Hemminki, Filip Ambrozkiewicz
Hepatocellular carcinoma (HCC) is primary liver cancer, frequently diagnosed at advanced stages with limited therapeutic options. MicroRNAs (miRNAs) regulate target gene expression and through inhibitory competitive binding of miRNA influence cellular processes including carcinogenesis. Extensive evidence proved that certain miRNA's are specifically expressed in neoplastic tissues of HCC patients and are confirmed as important factors that can participate in the regulation of key signalling pathways in cancer cells...
March 2024: Non-Coding RNA Research
https://read.qxmd.com/read/38066437/a-novel-endoplasmic-reticulum-stress-related-lncrna-signature-for-prognosis-prediction-and-immune-response-evaluation-in-stomach-adenocarcinoma
#22
JOURNAL ARTICLE
Zhaoxiang Song, Mengge Su, Xiangyu Li, Jinlin Xie, Fei Han, Jianning Yao
BACKGROUND: Stomach adenocarcinoma (STAD) is a significant contributor to cancer-related mortality worldwide. Although previous research has identified endoplasmic reticulum stress (ERS) as a regulator of various tumor-promoting properties of cancer cells, the impact of ERS-related long non-coding RNAs (lncRNAs) on STAD prognosis has not yet been investigated. Therefore, our study aims to develop and validate an ERS-related lncRNA signature that can accurately predict the prognosis of STAD patients...
December 9, 2023: BMC Gastroenterology
https://read.qxmd.com/read/38034714/integrating-bulk-and-single-cell-rna-sequencing-data-to-establish-necroptosis-related-lncrna-risk-model-and-analyze-the-immune-microenvironment-in-hepatocellular-carcinoma
#23
JOURNAL ARTICLE
Rongjie Zhang, Qian Li, Xiaoxiao Yu, Yiwen Hou, Liang Yan, Yating Gao, Longshan Ji, Xin Zhang, Miao Fang, Lingying Huang, Zhuo Yu, Yueqiu Gao, Man Li
BACKGROUND: The increasing evidence suggests that necroptosis mediates many behaviors of tumors, as well as the regulation of the tumor microenvironment. Long non-coding RNAs (lncRNAs) are involved in a variety of regulatory processes during tumor development and are significantly associated with patient prognosis. It suggests that necroptosis-related lncRNAs (NRlncRNAs) may serve as biomarkers for the prognosis of hepatocellular carcinoma (HCC). METHODS: lncRNA expression profiles of HCC were obtained from TCGA database...
November 2023: Heliyon
https://read.qxmd.com/read/38020298/usf1-modulates-transcription-and-cellular-functions-by-regulating-multiple-transcription-factors-in-huh7-cells
#24
JOURNAL ARTICLE
Yan-Li Zeng, Fei Gao, Can Zhang, Pei-Pei Ren, Li Ma, Xin Wang, Ruzhen Wang, Yi Kang, Ke Li
Liver cancer, including hepatocellular carcinoma (HCC), is a malignant tumor that has high rates of metastasis and mortality worldwide. Upstream transcription factor 1 (USF1) is a canonical transcription factor (TF) and is associated with the pathogenesis of several cancers, but its biological functions and molecular targets in HCC remain unclear. Huh7 cells that overexpress USF1 were used with whole transcriptome profiling through RNA sequencing and chromatin immunoprecipitation (ChIP) sequencing methods to investigate the downstream targets of USF1...
December 2023: Oncology Letters
https://read.qxmd.com/read/38013127/linc02561-promotes-metastasis-in-hcc-via-hif1-%C3%AE-ndrg1-upf1-axis
#25
JOURNAL ARTICLE
Sheng-Nan Li, Mei-Xiang Li, Wen-Wen Guo, Li-Rong Zhang, Yun-He Ding, Xiao-Jin Wu
In the entire world, hepatocellular carcinoma (HCC) is one of the most frequent cancers that lead to death. Experiments on the function of long non-coding RNAs in the emergence of malignancies, including HCC, are ongoing. As a crucial RNA monitoring mechanism in eucaryotic cells, nonsense-mediated mRNA decay (NMD) can recognize and destroy mRNAs, which has an premature termination codons (PTC) in the open reading frame to prevent harmful buildup of truncated protein products in the cells. Nonsense transcript regulator 1 (Up-frameshift suppressor 1, UPF1), as a highly conserved RNA helicase and ATPase, plays a key role in NMD...
November 25, 2023: Gene
https://read.qxmd.com/read/37957486/tumor-cell-derived-exosomes-mediating-hsa_circ_0001739-lncrna-ac159540-1-facilitate-liver-metastasis-in-colorectal-cancer
#26
JOURNAL ARTICLE
Cai-Feng Yue, Ju-Gao Chen, Zi-Yue Li, Lai-Sheng Li, Jie-Rong Chen, Hai-Xia Xie, Bin Zhang, Yun-Miao Guo
BACKGROUND: The current study probed into how tumor cell-derived exosomes (Exos) mediated hsa_circ_0001739/lncRNA AC159540.1 to manipulate microRNA (miR)-218-5p/FTO-N6-methyladenosine (m6A)/MYC signal axis in liver metastasis in colorectal cancer (CRC). METHODS: hsa_circ_0001739 and lncRNA AC159540.1 were identified as the upstream regulator of miR-218-5p using ENCORI and LncBase databases. Expression patterns of miR-218-5p, hsa_circ_0001739, lncRNA AC159540.1, FTO, and MYC were detected, accompanied by loss-and-gain-of function assays to examine their effects on CRC cell biological functions...
November 14, 2023: Cell Biology and Toxicology
https://read.qxmd.com/read/37950038/lncrna-mir31hg-fosters-stemness-malignant-features-of-non-small-cell-lung-cancer-via-h3k4me1-and-h3k27ace-mediated-gli2-expression
#27
JOURNAL ARTICLE
Weiwei Chen, Fei Wang, Xinyuan Yu, Jingjing Qi, Hongliang Dong, Bingjie Cui, Qian Zhang, Yan Wu, Jiajia An, Na Ni, Cuilan Liu, Yuchen Han, Shuo Zhang, Clemens A Schmitt, Jiong Deng, Yong Yu, Jing Du
Non-coding RNAs are responsible for oncogenesis and the development of stemness features, including multidrug resistance and metastasis, in various cancers. Expression of lncRNA MIR31HG in lung cancer tissues and peripheral sera of lung cancer patients were remarkably higher than that of healthy individuals and indicated a poor prognosis. Functional analysis showed that MIR31HG fosters stemness-associated malignant features of non-small cell lung cancer cells. Further mechanistic investigation revealed that MIR31HG modulated GLI2 expression via WDR5/MLL3/P300 complex-mediated H3K4me and H3K27Ace modification...
November 10, 2023: Oncogene
https://read.qxmd.com/read/37946148/construction-of-disulfidptosis-related-lncrna-signature-for-predicting-the-prognosis-and-immune-escape-in-colon-adenocarcinoma
#28
JOURNAL ARTICLE
Pan Chen, Jun Yu, Qian Luo, Jie Li, Wei Wang
Colon adenocarcinoma (COAD) is one of the most frequent types of cancer worldwide. Disulfidptosis has been identified as a new mode of cell death recently. The goal of this study was to explore the possibility of a connection between disulfidptosis and COAD. RNA sequencing data from COAD patients were retrieved from the The Cancer Genome Atlas (TCGA) database for this investigation. R software and various methods were used to identify disulfidptosis-related lncRNAs (DRLs) in COAD, and a prognostic model was created based on 6 DRLs (AP003555...
November 10, 2023: BMC Gastroenterology
https://read.qxmd.com/read/37945918/identification-of-a-bile-acid-and-bile-salt-metabolism-related-lncrna-signature-for-predicting-prognosis-and-treatment-response-in-hepatocellular-carcinoma
#29
JOURNAL ARTICLE
Hao Cui, Jia Lian, Baiguo Xu, Zhenjun Yu, Huiling Xiang, Jingxiang Shi, Yingtang Gao, Tao Han
Bile acids and salts have been shown to play a role in liver carcinogenesis through DNA damage, inflammation, and tumor proliferation. However, the correlation between bile acid metabolism and hepatocellular carcinoma (HCC) prognosis remains unclear. This study aimed to identify a predictive signature of bile acid and bile salt metabolism-related long non-coding RNAs (lncRNAs) for HCC prognosis and treatment response. The study used HCC RNA-sequencing data and corresponding clinical and prognostic data from The Cancer Genome Atlas...
November 9, 2023: Scientific Reports
https://read.qxmd.com/read/37941063/lncrna-mafg-as1-is-involved-in-human-cancer-progression
#30
REVIEW
Penghui Li, Xiao Ma, Xinyu Gu
Long noncoding RNAs (lncRNAs) refer to a type of non-protein-coding transcript of more than 200 nucleotides. LncRNAs play fundamental roles in disease development and progression, and lncRNAs are dysregulated in many pathophysiological processes. Thus, lncRNAs may have potential value in clinical applications. The lncRNA, MAF BZIP Transcription Factor G (MAFG)-AS1, is dysregulated in several cancer, including breast cancer, lung cancer, liver cancer, bladder cancer, colorectal cancer, gastric cancer, esophagus cancer, prostate cancer, pancreatic cancer, ovarian cancer, and glioma...
November 8, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37927237/snhg1-interacting-with-snd1-contributes-to-sorafenib-resistance-of-liver-cancer-cells-by-increasing-m6a-mediated-slc7a11-expression-and-promoting-aerobic-glycolysis
#31
JOURNAL ARTICLE
Rong Li, Shunle Li, Lin Shen, Junhui Li, Di Zhang, Jinmin Yu, Lanxuan Huang, Na Liu, Hongwei Lu, Meng Xu
Aerobic glycolysis plays an important role in multidrug resistance of cancer cells. Here, we screened different expressed lncRNAs associated with sorafenib resistance of liver cancer cells, by intersecting the bioinformatics analyses of TCGA and GEO (the GSE62813 dataset) databases. Our results revealed that the 18 upregulated lncRNAs in the intersection are associated with and enriched in metabolism of small molecule organic acids, suggesting their potential in glycolysis. The lncRNA small nucleolar RNA host gene 1 (Snhg1) was chosen as a potential regulator of aerobic glycolysis in liver cancer cells, for its significant promotion on lactate production...
November 6, 2023: Environmental Toxicology
https://read.qxmd.com/read/37898914/a-cuproptosis-related-lncrna-risk-model-for-predicting-prognosis-and-immunotherapeutic-efficacy-in-patients-with-hepatocellular-carcinoma
#32
JOURNAL ARTICLE
Shuo Wang, Hongyan Bai, Sujuan Fei, Bei Miao
Cuproptosis is a novel programmed cell death pathway that is initiated by direct binding of copper to lipoylated tricarboxylic acid (TCA) cycle proteins. Recent studies have demonstrated that cuproptosis-related genes regulate tumorigenesis. However, the potential role and clinical significance of cuproptosis-related long noncoding RNAs (lncRNAs) in hepatocellular carcinoma (HCC) have not been established. We performed a bioinformatics analyses of RNA-sequencing data of HCC patients extracted from The Cancer Genome Atlas (TCGA) dataset to identify and validate a cuproptosis-related lncRNA prognostic signature...
October 29, 2023: Biochemical Genetics
https://read.qxmd.com/read/37888625/transcriptome-analysis-of-deoxynivalenol-don-induced-hepatic-and-intestinal-toxicity-in-zebrafish-insights-into-gene-expression-and-potential-detoxification-pathways
#33
JOURNAL ARTICLE
Feng Yao, Miaomiao Zhao, Yaowen Du, Guoli Chang, Chuanpeng Li, Ruiyu Zhu, Chenggang Cai, Suqing Shao
The effects of deoxynivalenol (DON, 50 µg/mL) on the zebrafish liver and intestine were studied. Differentially expressed genes (DEGs) from mRNA and lncRNA were analyzed by RNA seq. Gene Ontology (GO) and signaling pathways were studied where the top 30 DEGs of each type of RNA were involved. The results showed there were 2325 up-regulated and 934 down-regulated DEGs of lncRNA in the intestinal tract, and 95 up-regulated genes and 211 down-regulated genes in the liver, respectively. GO functional annotation analysis showed that lncRNA was enriched in the biological processes, involving the RNA splicing, CSF1-CSF1R complexes, and MAP kinase activity...
October 2, 2023: Toxins
https://read.qxmd.com/read/37884580/lncrna-calml3-as1-modulated-by-m-6-a-modification-induces-btnl9-methylation-to-drive-non-small-cell-lung-cancer-progression
#34
JOURNAL ARTICLE
Heng Zhang, Shao-Qiang Wang, Jie-Bo Zhu, Li-Na Wang, Hang Lin, Lin-Feng Li, Yuan-Da Cheng, Chao-Jun Duan, Chun-Fang Zhang
Non-small cell lung cancer (NSCLC) is a common and lethal malignancy. The carcinogenic roles of lncRNA CALML3 antisense RNA 1 (CALML3-AS1) have been documented. However, the function and potential mechanisms of CALML3-AS1 in the progression of NSCLC need to be further explored. The molecule expression was assessed by qRT-PCR and Western blot. The subcellular localization of CALML3-AS1 was observed by fluorescence in situ hybridization (FISH). The malignant behaviors of NSCLC cells were evaluated by CCK-8, colony formation, EdU, wound healing and transwell assays...
October 27, 2023: Cancer Gene Therapy
https://read.qxmd.com/read/37880710/jmjd6-brd4-complex-stimulates-lncrna-hotair-transcription-by-binding-to-the-promoter-region-of-hotair-and-induces-radioresistance-in-liver-cancer-stem-cells
#35
JOURNAL ARTICLE
Ruifeng Pei, Le Zhao, Yiren Ding, Zhan Su, Deqiang Li, Shuo Zhu, Lu Xu, Wei Zhao, Wuyuan Zhou
BACKGROUND: Long non-coding RNA (lncRNA) HOTAIR acts importantly in liver cancer development, but its effect on radioresistance remains poorly understood. Here, our study probed into the possible impact of HOTAIR in radioresistance in liver cancer stem cells (LCSCs) and to elucidate its molecular basis. METHODS: Following sorting of stem and non-stem liver cancer cells, LCSCs were identified and subjected to RNA-seq analysis for selecting differentially expressed genes...
October 25, 2023: Journal of Translational Medicine
https://read.qxmd.com/read/37867671/construction-of-a-novel-cuproptosis-related-cerna-network-snhg3-mir-1306-5p-pdha1-and-identification-of-snhg3-as-a-prognostic-biomarker-in-hepatocellular-carcinoma
#36
JOURNAL ARTICLE
Yong Pan, Yiru Zhang, Xiaodan Hu, Shibo Li
The crucial role of competitive endogenous RNA (ceRNA) in the malignant biological behavior of tumors has been certificated. Nevertheless, the detailed function and molecular mechanism of ceRNA associated with cuproptosis in hepatocellular carcinoma (HCC) remains dismal. In this study, we first constructed a protein-protein interaction network and identified the module with the highest degree of aggregation degree. DLAT and PDHA1 were screened out of the module after differential expression and survival analysis...
October 17, 2023: ACS Omega
https://read.qxmd.com/read/37855346/lncrna-meg3-targeting-the-molecular-mechanisms-and-pathogenic-causes-of-metabolic-diseases
#37
JOURNAL ARTICLE
Yiyang Luo, Hailin Wang, Lijun Wang, Wei Wu, Jiale Zhao, Xueqing Li, Ruisi Xiong, Xueliang Ding, Ding Yuan, Chengfu Yuan
BACKGROUND: Non-coding RNA is a type of RNA that does not encode proteins, distributed among rRNA, tRNA, snRNA, snoRNA, microRNA and other RNAs with identified functions, where the Long non-coding RNA (lncRNA) displays a nucleotide length over 200. LncRNAs enable multiple biological processes in the human body, including cancer cell invasion and metastasis, apoptosis, cell autophagy, inflammation, etc. Recently, a growing body of studies has demonstrated the association of lncRNAs with obesity and obesity-induced insulin resistance and NAFLD, where MEG3 is related to glucose metabolism, such as insulin resistance...
October 19, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37851112/lncrna-snhg9-enhances-liver-cancer-stem-cell-self-renewal-and-tumorigenicity-by-negatively-regulating-pten-expression-via-recruiting-ezh2
#38
JOURNAL ARTICLE
Shouzhang Yang, Xiaojiao Ruan, Bingren Hu, Jinfu Tu, Huajie Cai
Liver cancer stem cell (CSC) self-renewal and tumorigenesis are important causes of hepatocellular carcinoma (HCC) recurrence. We purposed to investigate the function of long noncoding RNA small nucleolar RNA host gene 9 (SNHG9) in liver CSC self-renewal and tumorigenesis in this study. Flow cytometry was carried out to separate CD133+ Populations and CD133- Populations from HCC cell lines. A combination of CD133+ cells and Matrigel matrix was subcutaneously injected to create the NOD-SCID mouse xenograft tumor model...
October 18, 2023: Cell and Tissue Research
https://read.qxmd.com/read/37814867/-jag1-affects-monocytes-macrophages-to-reshape-the-pre-metastatic-niche-of-triple-negative-breast-cancer-through-lncrna-malat1-in-exosomes
#39
JOURNAL ARTICLE
M Xu, Y Shi, J Liu, M Wu, F Zhang, Z He, M Tang
OBJECTIVE: To investigate the effect of JAG1 on the activities of monocytes-macrophages in pre-metastatic niche (PMN) of triple-negative breast cancer (TNBC) and explore the possible regulatory mechanism. METHODS: JAG1 expression in human TNBC MDA-MB-231 and MDA-MB-231B cells was detected using quantitative real-time PCR (qRT-PCR).Ten female nude mice were inoculated with MDA-MB-231 cells ( n =5) or MDA-MB-231B cells ( n =5) in the mammary fat pad, and 6 weeks later, the tumor tissues were collected for immunohistochemistry...
September 20, 2023: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://read.qxmd.com/read/37813208/integrative-analysis-of-serum-derived-exosomal-lncrna-profiles-of-alveolar-echinococcosis-patients
#40
JOURNAL ARTICLE
Selçuk Özdemir, Selim Çomaklı, Sefa Küçükler, Nurhak Aksungur, Necip Altundaş, Salih Kara, Ercan Korkut, Şeyma Aydın, Betül Bağcı, Muhammed Hüdai Çulha, Gürkan Öztürk
Alveolar echinococcosis is a severe zoonotic disease caused by the pseudotumoral intrahepatic development of the larval stage of the tapeworm Echinococcus multilocularis. The diagnosis of alveolar echinococcosis is hard since it has features of liver cancer. LncRNAs are among the non-coding RNAs that have received the most attention in recent biomarker studies. Here, we aimed to identify the serum-derived exosomal lncRNAs associated with alveolar echinococcosis in humans with RNA-seq. After RNA isolation from exosomes, we performed RNA-seq to determine the lncRNAs...
October 7, 2023: Gene
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