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liver cancer lncRNA

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https://www.readbyqxmd.com/read/28339471/expression-quantitative-trait-loci-for-pax8-contributes-to-the-prognosis-of-hepatocellular-carcinoma
#1
Shijie Ma, Jianshui Yang, Ci Song, Zijun Ge, Jing Zhou, Guoxin Zhang, Zhibin Hu
Paired-box family member PAX8 encodes a transcription factor that has a role in cell differentiation and cell growth and may participate in the prognosis of hepatocellular carcinoma (HCC). By bioinformatics analysis, we identified several single nucleotide polymorphisms (SNPs) within a newly identified long non-coding RNA (lncRNA) AC016683.6 as expression quantitative trait loci (eQTLs) for PAX8. Hence, we hypothesized that PAX8eQTLs in lncRNA AC016683.6 may influence the HCC prognosis. We then performed a case-only study to assess the association between the two SNPs as well as the prognosis of HCC in 331 HBV-positive HCC patients without surgical treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28280353/long-non-coding-rna-ccat2-is-associated-with-poor-prognosis-in-hepatocellular-carcinoma-and-promotes-tumor-metastasis-by-regulating-snail2-mediated-epithelial-mesenchymal-transition
#2
Yongfu Xu, Binfeng Wang, Fabiao Zhang, Aidong Wang, Xuefeng Du, Peng Hu, Yu Zhu, Zheping Fang
Increasing evidence has demonstrated that aberrant expressions of long non-coding RNAs (lncRNAs) are involved in various malignancies, including hepatocellular carcinoma (HCC). This study aimed to investigate the role of lncRNA colon cancer-associated transcript 2 (CCAT2) in the progression of HCC. Quantitative real-time polymerase chain reaction analysis confirmed that CCAT2 was upregulated in HCC cell lines and cancerous tissues compared with normal liver cell line and adjacent normal tissue samples. The level of CCAT2 was positively associated with tumor-node-metastasis stages and vessel invasion...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28260918/long-noncoding-rna-neat1-promotes-cell-proliferation-and-invasion-by-regulating-hnrnp-a2-expression-in-hepatocellular-carcinoma-cells
#3
Yuanyi Mang, Li Li, Jianghua Ran, Shengning Zhang, Jing Liu, Laibang Li, Yiming Chen, Jian Liu, Yang Gao, Gang Ren
Growing evidence demonstrates that long noncoding RNAs (lncRNAs) are involved in the progression of various cancers, including hepatocellular carcinoma (HCC). The role of nuclear-enriched abundant transcript 1 (NEAT1), an essential lncRNA for the formation of nuclear body paraspeckles, has not been fully explored in HCC. We aimed to determine the expression, roles and functional mechanisms of NEAT1 in the proliferation and invasion of HCC. Based on real-time polymerase chain reaction data, we suggest that NEAT1 is upregulated in HCC tissues compared with noncancerous liver tissues...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28260109/absence-of-malat1-does-not-prevent-den-induced-hepatocarcinoma-in-mice
#4
Stéphanie Miard, Marie-Josée Girard, Philippe Joubert, Sophie Carter, Amy Gonzales, Huiping Guo, Benjamin Morpurgo, Louise Boivin, Andrei Golovko, Frédéric Picard
Long non-coding RNAs (lncRNA) are key regulators of gene expression both at the transcriptional and post-transcriptional levels. The lncRNA metastasis associated lung adenocarcinoma transcript 1 (Malat1) is overexpressed in many types of cancer, including hepatocarcinoma, and induces cell proliferation in several cell lines in vitro. However, the direct causal effects of Malat1 on hepatocyte proliferation and liver carcinogenesis in vivo are not fully understood. To better determine the contribution of Malat1 to hepatocarcinoma oncogenesis, this study was aimed at testing the hypothesis that its absence confers resistance to the development of liver tumors...
February 20, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28166203/lncrna-hulc-triggers-autophagy-via-stabilizing-sirt1-and-attenuates-the-chemosensitivity-of-hcc-cells
#5
H Xiong, Z Ni, J He, S Jiang, X Li, J He, W Gong, L Zheng, S Chen, B Li, N Zhang, X Lyu, G Huang, B Chen, Y Zhang, F He
Considerable evidences have shown that autophagy has an important role in tumor chemoresistance. However, it is still unknown whether the lncRNA HULC (highly upregulated in liver cancer) is involved in autophagy and chemoresistance of hepatocellular carcinoma (HCC). In this study, we for the first time demonstrated that treatment with antitumor reagents such as oxaliplatin, 5-fluorouracil and pirarubicin (THP) dramatically induced HULC expression and protective autophagy. Silencing of HULC sensitized HCC cells to the three antitumor reagents via inhibiting protective autophagy...
February 6, 2017: Oncogene
https://www.readbyqxmd.com/read/28088733/long-non-coding-rna-uc001kfo-promotes-hepatocellular-carcinoma-proliferation-and-metastasis-by-targeting-%C3%AE-sma
#6
Yanfeng Pan, Tao Qin, Shenglu Yin, Xianqiang Zhang, Xiaojuan Gao, Lifen Mu
Several long non-coding RNAs (lncRNAs) have been investigated and found to be correlated with the behaviours and prognosis of hepatocellular carcinoma (HCC); Specifically, we revealed that the lncRNA UC001kfo was differentially expressed in HCC tissues compared with normal liver tissues using lncRNA microarrays, but its functional role in cancers, including HCC, has not yet been elucidated. The present study found that the expression of UC001kfo was upregulated in HCC tissues and cell lines in comparison with tumour-adjacent tissues and normal hepatocytes, respectively...
March 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28053545/high-expression-of-long-noncoding-rna-hulc-is-a-poor-predictor-of-prognosis-and-regulates-cell-proliferation-in-glioma
#7
Hong Yan, Rui Tian, Min Zhang, Jing Wu, Min Ding, Jie He
PURPOSE: Emerging studies show that long noncoding RNAs (lncRNAs) have important roles in carcinogenesis. This study investigated the role of lncRNA highly upregulated in liver cancer (HULC) expression in glioma and its clinical significance in glioma patients. MATERIALS AND METHODS: HULC expression was detected in glioma tissues and cell lines by using real-time quantitative reverse transcription polymerase chain reactions. Association between HULC levels and clinicopathological factors and patients prognosis was also analyzed...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28027578/lncrna-hulc-modulates-the-phosphorylation-of-yb-1-through-serving-as-a-scaffold-of-erk-and-yb-1-to-enhance-hepatocarcinogenesis
#8
Dan Li, Xuefeng Liu, Jian Zhou, Jie Hu, Dongdong Zhang, Jing Liu, Yanyan Qiao, Qimin Zhan
Dysregulated expressions of lncRNAs have been reported in many types of cancers, indicating that they may play critical roles in tumorigenesis. HULC (Highly Up-regulated in Liver Cancer) was firstly characterized in hepatocelluar carcinoma (HCC). However, the detailed mechanisms of HULC remain unclear. Here, we demonstrated a novel mechanism by which lncRNA plays oncogenic roles through modulating the phosphorylation status of its interaction protein. First, we validated that the remarkably increased expression levels of HULC in HCC tissues compared to their adjacent non-cancerous tissues...
December 27, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27986124/long-noncoding-rna-highly-up-regulated-in-liver-cancer-predicts-unfavorable-outcome-and-regulates-metastasis-by-mmps-in-triple-negative-breast-cancer
#9
Feng Shi, Fang Xiao, Ping Ding, Hong Qin, Ruixue Huang
BACKGROUND AND AIMS: Long noncoding RNA (lncRNA) highly up-regulated in liver cancer (HULC) is the first identified lncRNA highly expressed in hepatocellular carcinoma and acts as an oncogenic lncRNA. However, the significance of HULC in triple-negative breast cancer (TNBC) is still unclear. Our purpose is to explore the clinical significance and biological function of HULC in TNBC. METHODS: Expression of HULC in TNBC tissues and cell lines was measured and the association between HULC expression and clinicopathological factors was analyzed...
August 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27979710/hotair-facilitates-hepatic-stellate-cells-activation-and-fibrogenesis-in-the-liver
#10
Er-Bao Bian, Yuan-Yuan Wang, Yang Yang, Bao-Ming Wu, Tao Xu, Xiao-Ming Meng, Cheng Huang, Lei Zhang, Xiong-Wen Lv, Zhi-Gang Xiong, Jun Li
Long non-coding RNAs (lncRNAs) are increasingly recognized as major players in regulating various biological processes. LncRNA HOX transcript antisense RNA (Hotair) has been extensively studied in cancer. However, the role of Hotair in liver fibrosis remains unknown. Here we observed that Hotair expression was significantly increased in CCl4-induced mouse liver fibrosis models, human fibrotic livers and activated hepatic stellate cells (HSCs) by TGF-β1 stimulation. Enforced expression of Hotair in LX-2 cells promoted cell proliferation and activation while inhibition of its expression had an opposite effect...
December 13, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27943263/distinct-hepatitis-b-virus-integration-patterns-in-hepatocellular-carcinoma-and-adjacent-normal-liver-tissue
#11
Xiaobo Yang, Liangcai Wu, Jianzhen Lin, Anqiang Wang, Xueshuai Wan, Yan Wu, Simon C Robson, Xinting Sang, Haitao Zhao
Infection by the hepatitis B virus (HBV) is one of the main etiologies of hepatocellular carcinoma (HCC). During chronic infection, HBV DNA can integrate into the human genome, and this has been postulated as a possible mechanism of HBV-induced HCC. In this study we used 2199 HBV integration sites from Dr.VIS v2.0 and mapped them to the human genome (hg19) to obtain viral integration sites (VIS) related to protein-coding and non-protein-coding genes. In total, we found 1,377 and 767 VIS within close proximity to protein coding genes and noncoding genes, respectively...
March 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27912775/a-novel-long-non-coding-rna-lnc-gnat1-1-is-low-expressed-in-colorectal-cancer-and-acts-as-a-tumor-suppressor-through-regulating-rkip-nf-%C3%AE%C2%BAb-snail-circuit
#12
Chunxiang Ye, Zhanlong Shen, Bo Wang, Yansen Li, Tao Li, Yang Yang, Kewei Jiang, Yingjiang Ye, Shan Wang
BACKGROUND: The role of long non-coding RNAs (lncRNAs) in colorectal cancer (CRC) progression has not fully been elucidated. This study was designed to report the identification of a novel lncRNA, lnc-GNAT1-1, and its functional role in CRC progression. METHODS: lncRNA expression profile microarray was performed in three paired primary and liver metastatic tissues of CRC, and a novel lncRNA, lnc-GNAT1-1, was identified to be a potential functional lncRNA. Quantitative real-time PCR was used to detect its expression in CRC tissues, cell lines, and patients' plasma, cell fractionation was used to evaluate its subcellular location...
December 3, 2016: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27905400/lncbrm-initiates-yap1-signalling-activation-to-drive-self-renewal-of-liver-cancer-stem-cells
#13
Pingping Zhu, Yanying Wang, Jiayi Wu, Guanling Huang, Benyu Liu, Buqing Ye, Ying Du, Guangxia Gao, Yong Tian, Lei He, Zusen Fan
Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and heterogeneity of hepatocellular carcinoma (HCC). However, the biology of hepatic CSCs remains largely undefined. Through analysis of transcriptome microarray data, we identify a long noncoding RNA (lncRNA) called lncBRM, which is highly expressed in liver CSCs and HCC tumours. LncBRM is required for the self-renewal maintenance of liver CSCs and tumour initiation. In liver CSCs, lncBRM associates with BRM to initiate the BRG1/BRM switch and the BRG1-embedded BAF complex triggers activation of YAP1 signalling...
December 1, 2016: Nature Communications
https://www.readbyqxmd.com/read/27896271/expression-and-clinical-significance-of-the-novel-long-noncoding-rna-znf674-as1-in-human-hepatocellular-carcinoma
#14
Lufei Zhang, Tianyu He, Yingcai Yan, Yuan Zhang, Xiaohu Zhou, Pengfei Huang, Yang Kong, Minjie Xie, Linshi Zhang, Qiang Sun, Dongkai Zhou, Haiyang Xie, Lin Zhou, Shusen Zheng, Weilin Wang
Long noncoding RNAs (lncRNAs) play crucial roles in cancer occurrence and progression. However, the relationship between the expression levels of lncRNAs and the hepatocellular carcinoma (HCC) process is unclear. The goal of this study was to determine the expression level of ZNF674-AS1, a newly found lncRNA, in HCC and its clinical association. The expression of ZNF674-AS1 in 137 pairs of tumorous and adjacent normal tissues from patients with HCC was detected by quantitative real-time reverse transcription polymerase chain reaction...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27895772/hotair-a-long-non-coding-rna-driver-of-malignancy-whose-expression-is-activated-by-foxc1-negatively-regulates-mirna-1-in-hepatocellular-carcinoma
#15
Dong-Na Su, Shi-Pin Wu, Hong-Tao Chen, Jin-Hua He
Evidence is rapidly accumulating that long non-coding RNAs (lncRNAs) are involved in human tumorigenesis and are dysregulated in multiple cancers, including hepatocellular carcinoma (HCC). lncRNAs can regulate essential pathways that contribute to tumor initiation and progression with tissue specificity, which suggests that lncRNAs may be valuable biomarkers and therapeutic targets. HOX transcript antisense intergenic RNA (HOTAIR) has previously been demonstrated to be an oncogene and a negative prognostic factor in a variety of cancers; however, the factors that contribute to the upregulation of HOTAIR and the interaction between HOTAIR and microRNAs (miRNAs or miRs) are largely unknown...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27895760/prioritization-of-non-coding-disease-causing-variants-and-long-non-coding-rnas-in-liver-cancer
#16
Hua Li, Zekun He, Yang Gu, Lin Fang, Xin Lv
There are multiple bioinformatics tools available for the detection of coding driver mutations in cancers. However, the prioritization of pathogenic non-coding variants remains a challenging and demanding task. The present study was performed to discriminate non-coding disease-causing mutations and prioritize potential cancer-implicated long non-coding RNAs (lncRNAs) in liver cancer using a logistic regression model. A logistic regression model was constructed by combining 19,153 disease-associated ClinVar and human gene mutation database pathogenic variants as the response variable and non-coding features as the predictor variable...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27766570/long-noncoding-rna-tcf7-promotes-invasiveness-and-self-renewal-of-human-non-small-cell-lung-cancer-cells
#17
Jinhui Wu, Dongshuang Wang
Lung cancer is the most common solid tumor and the leading cause of cancer-related death worldwide. Non-small cell lung cancer (NSCLC) represents the major histological subtype and accounts for about 80 % cases of lung cancer cases. Recently, lncRNA lncTCF7 was identified, which is highly expressed in hepatocellular carcinoma (HCC) tumors and liver cancer stem cells (CSCs). However, the role of lnTCF7 in NSCLC remains largely unknown. In this study, Gain- and loss-of-function studies demonstrated the critical role of lncTCF7 in promoting invasion and self-renewal in NSCLC cells...
January 2017: Human Cell
https://www.readbyqxmd.com/read/27669232/long-noncoding-rna-lnccamta1-promotes-proliferation-and-cancer-stem-cell-like-properties-of-liver-cancer-by-inhibiting-camta1
#18
Li-Juan Ding, Yan Li, Shu-Dong Wang, Xin-Sen Wang, Fang Fang, Wei-Yao Wang, Peng Lv, Dong-Hai Zhao, Feng Wei, Ling Qi
Hepatocellular carcinoma (HCC) is the most common subtype of liver malignancy, and it is characterized by poor prognosis because of cancer stem cell (CSC)-mediated high postsurgical recurrence rates. Thus, targeting CSCs, or HCC cells with CSC-like properties, is an effective strategy for HCC therapy. Here, using long noncoding RNA (lncRNA) microarray analysis, we identified a novel lncRNA termed lncCAMTA1 that is increased in both liver CSCs and HCC. High lncCAMTA1 expression in HCC indicates poor clinical outcome...
September 23, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27588491/long-non-coding-rna-pvt1-activates-hepatic-stellate-cells-through-competitively-binding-microrna-152
#19
Jianjian Zheng, Fujun Yu, Peihong Dong, Limei Wu, Yuan Zhang, Yanwei Hu, Lei Zheng
Epithelial-mesenchymal transition (EMT) process is considered as a key event in the activation of hepatic stellate cells (HSCs). Hedgehog (Hh) pathway is known to be required for EMT process. Long non-coding RNAs (lncRNAs) have been reported to be involved in a wide range of biological processes. Plasmacytoma variant translocation 1 (PVT1), a novel lncRNA, is often up-regulated in various human cancers. However, the role of PVT1 in liver fibrosis remains undefined. In this study, PVT1 was increased in fibrotic liver tissues and activated HSCs...
September 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27553854/lncsox4-promotes-the-self-renewal-of-liver-tumour-initiating-cells-through-stat3-mediated-sox4-expression
#20
Zhen-Zhen Chen, Lan Huang, Ya-Hong Wu, Wen-Jie Zhai, Ping-Ping Zhu, Yan-Feng Gao
Liver cancer has a tendency to develop asymptomatically in patients, so most patients are diagnosed at a later stage. Accumulating evidence implicates that liver tumour-initiating cells (TICs) as being responsible for liver cancer initiation and recurrence. However, the molecular mechanism of liver TIC self-renewal is poorly understood. Here we discover that a long noncoding RNA (lncRNA) termed LncSox4 is highly expressed in hepatocellular carcinoma (HCC) tissues and in liver TICs. We find that LncSox4 is required for liver TIC self-renewal and tumour initiation...
2016: Nature Communications
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