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https://read.qxmd.com/read/38482448/the-diagnostic-prognostic-drug-sensitivity-and-cerna-internet-of-ppp4r1-in-liver-hepatocellular-carcinoma-lihc
#1
JOURNAL ARTICLE
Xiaowei Li, Yinglian Pan, Siren Feng, Weimei Xing, Bo Lin, Wei Li, Mengsen Li, Mingyue Zhu
BACKGROUND: Recent studies have reported a role of protein phosphatase 4 regulatory subunit 1 ( PPP4R1 ) in cancer development. However, its expression, diagnostic significance, prognostic value and biological function in liver hepatocellular carcinoma (LIHC) are not known. METHODS: The expression level of PPP4R1 in pan-cancer was evaluated by analyzing publicly accessible data from the University of California Santa Cruz (UCSC) Xena database. The diagnostic value of PPP4R1 for tumors was assessed using receiver operating characteristic (ROC) curves, whereas the impact of PPP4R1 on tumor prognosis was determined using Kaplan-Meier survival curves, and a prognostic model for LIHC was established using cox regression analysis...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38460179/hepatocellular-carcinoma-linc01116-outcompetes-t-cells-for-linoleic-acid-and-accelerates-tumor-progression
#2
JOURNAL ARTICLE
Kun Ma, Junhui Chu, Yufeng Liu, Linmao Sun, Shuo Zhou, Xianying Li, Changyong Ji, Ning Zhang, Xinyu Guo, Shuhang Liang, Tianming Cui, Qingsong Hu, Jiabei Wang, Yao Liu, Lianxin Liu
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer with a highly immunosuppressive tumor microenvironment and a typical pattern of disturbances in hepatic lipid metabolism. Long non-coding RNAs are shown to play an important role in the regulation of gene expression, but much remains unknown between tumor microenvironment and lipid metabolism as a bridging molecule. Here, long intergenic nonprotein coding RNA 01116 (LINC01116) acts as this molecular which is frequently upregulated in HCC patients and associated with HCC progression in vitro and in vivo is identified...
March 9, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38438584/lncrna-snhg5-mediates-activation-of-hepatic-stellate-cells-by-regulating-nf2-and-hippo-pathway
#3
JOURNAL ARTICLE
Rongrong Zhang, Yating Zhan, Zhichao Lang, Yifei Li, Weizhi Zhang, Jianjian Zheng
Long noncoding RNA small nucleolar RNA host gene 5 (SNHG5) is an oncogene found in various human cancers. However, it is unclear what role SNHG5 plays in activating hepatic stellate cells (HSCs) and liver fibrosis. In this study, SNHG5 was found to be upregulated in activated HSCs in vitro and in primary HSCs isolated from fibrotic liver in vivo, and inhibition of SNHG5 suppressed HSC activation. Notably, Neurofibromin 2 (NF2), the main activator for Hippo signalling, was involved in the effects of SNHG5 on HSC activation...
March 4, 2024: Communications Biology
https://read.qxmd.com/read/38426568/-corrigendum-long-non%C3%A2-coding-rna-linc00238-suppresses-the-malignant-phenotype-of-liver-cancer-by-sponging-mir%C3%A2-522
#4
Hong-Gang Qian, Qiong Wu, Jian-Hui Wu, Xiu-Yun Tian, Wei Xu, Chun-Yi Hao
Subsequently to the publication of the above article, an interested reader drew to the authors' attention that two pairs of data panels featured in Figs. 2E and 6D, portraying the results from cell invasion and migration assay experiments, appeared to contain overlapping sections, such that data which were intended to show the results from differently performed experiments had apparently been derived from a smaller number of original sources. The authors were able to re‑examine their original data (which was also presented to the Editorial Office), and realized that errors has been made in the compilation of Fig...
April 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38426536/m6a-methyltransferase-mettl14%C3%A2-mediated-rp1%C3%A2-228h13-5-promotes-the-occurrence-of-liver-cancer-by-targeting-hsa%C3%A2-mir%C3%A2-205-zik1
#5
JOURNAL ARTICLE
Jia Xu, Chang Liu, Kai Qu, Jingyao Zhang, Sinan Liu, Fandi Meng, Yong Wan
The aim of the present study was to explore the association between N6 ‑methyladenosine (m6A) modification regulatory gene‑related long noncoding (lnc)RNA RP1‑228H13.5 and cancer prognosis through bioinformatics analysis, as well as the impact of RP1‑228H13.5 on cell biology‑related behaviors and specific molecular mechanisms. Bioinformatics analysis was used to construct a risk model consisting of nine genes. This model can reflect the survival time and differentiation degree of cancer...
April 2024: Oncology Reports
https://read.qxmd.com/read/38378545/identification-of-functional-genes-in-liver-fibrosis-based-on-bioinformatics-analysis-of-a-lncrna-mediated-cerna-network
#6
JOURNAL ARTICLE
Feng Zhang, Siya Pei, Meifang Xiao
BACKGROUND: Liver fibrosis is a major global healths problem; nevertheless, its molecular mechanism are not completely clear. This study aimed to build a lncRNA-miRNA-mRNA network, identify potentially related lncRNAs, and explore the pathogenesis of liver fibrosis. MATERIALS AND METHODS: We used the Gene Expression Omnibus databases and bioinformatics analysis to identify differentially expressed genes (DEGs) between liver fibrosis and normal tissues. The ceRNA network was constructed according to the interactions between DElncRNA, miRNA, and DEmRNA...
February 20, 2024: BMC Medical Genomics
https://read.qxmd.com/read/38347289/featured-lncrna-based-signature-for-discriminating-prognosis-and-progression-of-hepatocellular-carcinoma
#7
JOURNAL ARTICLE
Huiyuan Qiu, Bo Jiang, Yinqi Chen, Zhaoyi Lin, Wenjie Zheng, Xianglei Cao
Long non-coding RNAs (lncRNAs) have been implicated in carcinogenesis and progression of hepatocellular carcinoma (HCC). This study aimed to identify a robust lncRNA signature for predicting the survival of HCC patients. We performed an integrated analysis of the lncRNA expression profiling in The Cancer Genome Atlas (TCGA)-liver hepatocellular carcinoma database to identify the prognosis-related lncRNA for the HCC. The HCC cohort was randomly divided into a training set (n = 250) and a testing set (n = 113)...
February 12, 2024: Journal of Applied Genetics
https://read.qxmd.com/read/38334792/development-of-a-novel-lncrna-derived-immune-gene-score-using-machine-learning-based-ensembles-for-predicting-the-survival-of-hcc
#8
JOURNAL ARTICLE
Qun Cai, Guoqi Li, Mingyan Zhu, Tingting Zhuo, Jiaying Xiao
BACKGROUND: Long noncoding RNAs (lncRNAs) are implicated in the tumor immunology of hepatocellular carcinoma (HCC). METHODS: HCC mRNA and lncRNA expression profiles were used to extract immune-related genes with the ImmPort database, and immune-related lncRNAs with the ImmLnc algorithm. The MOVICS package was used to cluster immune-related mRNA, immune-related lncRNA, gene mutation and methylation data on HCC from the TCGA. GEO and ICGC datasets were used to validate the model...
February 9, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38332153/tgf%C3%AE-induced-long-non-coding-rna-linc00313-activates-wnt-signaling-and-promotes-cholangiocarcinoma
#9
JOURNAL ARTICLE
Panagiotis Papoutsoglou, Raphaël Pineau, Raffaële Leroux, Corentin Louis, Anaïs L'Haridon, Dominika Foretek, Antonin Morillon, Jesus M Banales, David Gilot, Marc Aubry, Cédric Coulouarn
Cholangiocarcinoma is a devastating liver cancer characterized by high aggressiveness and therapy resistance, resulting in poor prognosis. Long non-coding RNAs and signals imposed by oncogenic pathways, such as transforming growth factor β (TGFβ), frequently contribute to cholangiocarcinogenesis. Here, we explore novel effectors of TGFβ signalling in cholangiocarcinoma. LINC00313 is identified as a novel TGFβ target gene. Gene expression and genome-wide chromatin accessibility profiling reveal that nuclear LINC00313 transcriptionally regulates genes involved in Wnt signalling, such as the transcriptional activator TCF7...
February 8, 2024: EMBO Reports
https://read.qxmd.com/read/38317193/targeting-of-h19-cell-adhesion-molecules-circuitry-by-gsk-j4-epidrug-inhibits-metastatic-progression-in-prostate-cancer
#10
JOURNAL ARTICLE
Valeria Pecci, Fabiola Troisi, Aurora Aiello, Sara De Martino, Angela Carlino, Vincenzo Fiorentino, Cristian Ripoli, Dante Rotili, Francesco Pierconti, Maurizio Martini, Manuela Porru, Francesco Pinto, Antonello Mai, Pier Francesco Bassi, Claudio Grassi, Carlo Gaetano, Alfredo Pontecorvi, Lidia Strigari, Antonella Farsetti, Simona Nanni
BACKGROUND: About 30% of Prostate cancer (PCa) patients progress to metastatic PCa that remains largely incurable. This evidence underlines the need for the development of innovative therapies. In this direction, the potential research focus might be on long non-coding RNAs (lncRNAs) like H19, which serve critical biological functions and show significant dysregulation in cancer. Previously, we showed a transcriptional down-regulation of H19 under combined pro-tumoral estrogen and hypoxia treatment in PCa cells that, in turn, induced both E-cadherin and β4 integrin expression...
February 5, 2024: Cancer Cell International
https://read.qxmd.com/read/38308967/unveiling-the-role-of-ferroptosis-associated-exosomal-non-coding-rnas-in-cancer-pathogenesis
#11
REVIEW
Yiping Zhang, Jun Xie
The pivotal regulatory role of non-coding RNAs (ncRNAs), especially exosomal ncRNAs, in ferroptosis significantly influences cancer cell fate. This review explores their involvement across various human cancers, focusing on microRNAs (miRNA), long non-coding RNAs (lncRNA), and circular RNAs (circRNA). These ncRNAs either stimulate or inhibit ferroptosis by targeting key components, impacting cancer susceptibility to this form of cell death. Specific studies in lung, gastric, liver, cervical, bladder, pancreatic, and osteosarcoma cancers underscore the crucial role of exosomal ncRNAs in modulating ferroptosis, influencing cancer progression, and therapeutic responses...
February 2, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38297160/role-of-upf1-in-lncrna-heih-regulation-for-hepatocellular-carcinoma-therapy
#12
JOURNAL ARTICLE
Hyunho Cha, Minwoo Kim, Narae Ahn, Seong Dong Jeong, Elizaveta Ignatova, Sung Wook Chi, Hyeon Ho Kim, Jungwook Hwang
UPF1, a novel posttranscriptional regulator, regulates the abundance of transcripts, including long noncoding RNAs (lncRNAs), and thus plays an important role in cell homeostasis. In this study, we revealed that UPF1 regulates the abundance of hepatocellular carcinoma upregulated EZH2-associated lncRNA (lncRNA-HEIH) by binding the CG-rich motif, thereby regulating hepatocellular carcinoma (HCC) tumorigenesis. UPF1-bound lncRNA-HEIH was susceptible to degradation mediated by UPF1 phosphorylation via SMG1 and SMG5...
February 1, 2024: Experimental & Molecular Medicine
https://read.qxmd.com/read/38293480/a-prognostic-exosome-related-long-non-coding-rnas-risk-model-related-to-the-immune-microenvironment-and-therapeutic-responses-for-patients-with-liver-hepatocellular-carcinoma
#13
JOURNAL ARTICLE
Yuan Yue, Jie Tao, Dan An, Lei Shi
BACKGROUND: Liver hepatocellular carcinoma (LIHC) is the third largest cause of cancer mortality. Exosomes are vital regulators in the development of cancer. However, the mechanisms regarding the association of exosome-related long non-coding RNAs (lncRNAs) in LIHC are not clear. METHODS: LIHC RNA sequences and exosome-associated genes were collected according to The Cancer Genome Atlas (TCGA), Hepatocellular Carcinoma Cell DataBase (HCCDB) and ExoBCD databases, and exosome-related lncRNAs with prognostic differential expression were screened as candidate lncRNAs using Spearman's method and univariate Cox regression analysis...
January 30, 2024: Heliyon
https://read.qxmd.com/read/38230218/eps15-as1-inhibits-akr1b1-expression-to-enhance-ferroptosis-in-hepatocellular-carcinoma-cells
#14
JOURNAL ARTICLE
Quan Man, Guoyou Zhang, Xiaojun Chen, Sa Ren Na, Siguleng Bai, Haoqiang Zhi, Ling Sun, Huifang Pang
Epidermal growth factor receptor substrate 15 (EPS15) is part of the EGFR pathway and has been implicated in various tumorigenesis. Increasing evidence suggests that long noncoding RNA (lncRNA) plays an essential role in liver hepatocellular carcinoma (LIHC) by regulating the expression of proteins and genes. Through analysis of the cancer genome atlas (TCGA) database, we found that EPS15 is highly expressed in LIHC tissue, and lncRNA EPS15-antisense1 (EPS15-AS1) decreased in LIHC cell lines. However, the function of EPS15-AS1 in LIHC is still unknown...
2024: Journal of Cancer
https://read.qxmd.com/read/38213732/a-concise-review-of-the-regulatory-diagnostic-and-prognostic-implications-of-hoxb-as3-in-tumors
#15
REVIEW
Hongze Wu, Jiarong Ye, Mengqi Zhang, Hongliang Luo
Recent studies have reported that HOXB-AS3 (HOXB Cluster Antisense RNA 3) is an intriguing molecule with dual functionality as a long noncoding RNA (lncRNA) and putative coding peptide in tumorigenesis and progression. The significant expression alterations of HOXB-AS3 were detected in diverse cancer types and closely correlated with clinical stage and patient survival. Furthermore, HOXB-AS3 was involved in a spectrum of biological processes in solid tumors and hematological malignancies, such as stemness, lipid metabolism, migration, invasion, and tumor growth...
2024: Journal of Cancer
https://read.qxmd.com/read/38199212/liquid-liquid-phase-separation-related-lncrna-prognostic-signature-and-znf32-as2-as-a-novel-biomarker-in-hepatocellular-carcinoma
#16
JOURNAL ARTICLE
Wang Peng, Yanling Li, Bin Cheng, Mengdie Cao, Luyao Liu, Yilei Yang, Shuya Bai, Si Xiong, Wei Chen, Yuchong Zhao
BACKGROUND: Liquid-liquid phase separation (LLPS) enhances oncogenic signaling pathways and advances cancer progression, and has been proposed as a promising cancer biomarker and intervention target. Nevertheless, doubts remain about the prognostic importance of LLPS-related long non-coding RNAs (lncRNAs) in hepatocellular carcinoma (HCC). METHODS: An LLPS-related lncRNA prognostic signature was generated by drivers and regulators of LLPS, and was validated in external datasets...
January 6, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38192253/deciphering-role-of-lncrna-91h-in-liver-cancer-impact-on-tumorigenesis
#17
JOURNAL ARTICLE
Zhiyuan Mo, Zhuangqiang Wang
OBJECTIVE: This study aimed to investigate functional role of long ncRNA (lncRNA) 91H in liver cancer tumorigenesis, focusing on its effect on cell proliferation, apoptosis, cell cycle progression, migration, invasion, epithelial-mesenchymal transition (EMT) and In vivo tumor growth. MATERIALS AND METHODS: In this experimental study, liver cancer tissues and cell lines were analyzed for lncRNA 91H expression using quantitative reverse transcription polymerase chain reaction (qRT-PCR)...
December 31, 2023: Cell Journal
https://read.qxmd.com/read/38161583/crnde-a-pivotal-oncogenic-long-non-coding-rna-in-cancers
#18
REVIEW
Yi Zhen Hor, Shamala Salvamani, Baskaran Gunasekaran, Koh Rhun Yian
Colorectal Neoplasia Differentially Expressed (CRNDE), a long non-coding RNA that was initially identified as aberrantly expressed in colorectal cancer (CRC) has also been observed to exhibit elevated expression in various other human malignancies. Recent research has accumulated substantial evidence implicating CRNDE as an oncogenic player, exerting influence over critical cellular processes linked to cancer progression. Particularly, its regulatory interactions with microRNAs and proteins have been shown to modulate pathways that contribute to carcinogenesis and tumorigenesis...
December 2023: Yale Journal of Biology and Medicine
https://read.qxmd.com/read/38129820/lum-as-a-novel-prognostic-marker-and-its-correlation-with-immune-infiltration-in-gastric-cancer-a-study-based-on-immunohistochemical-analysis-and-bioinformatics
#19
JOURNAL ARTICLE
Wu Xu, Shasha Chen, Qiuju Jiang, Jinlan He, Feifei Zhang, Zhuying Wang, Caishun Ruan, Bin Shi
BACKGROUND: Gastric cancer (GC) is considered the sixth highly prevailing malignant neoplasm and is ranked third in terms of cancer mortality rates. To enable an early and efficient diagnosis of GC, it is important to detect the fundamental processes involved in the oncogenesis and progression of gastric malignancy. The understanding of molecular signaling pathways can facilitate the development of more effective therapeutic strategies for GC patients. METHODS: The screening of genes that exhibited differential expression in early and advanced GC was performed utilizing the Gene Expression Omnibus databases (GSE3438)...
December 21, 2023: BMC Gastroenterology
https://read.qxmd.com/read/38083905/identification-of-ap002498-1-and-linc01871-as-prognostic-biomarkers-and-therapeutic-targets-for-distant-metastasis-of-colorectal-adenocarcinoma
#20
JOURNAL ARTICLE
Na Wu, Jingyi Chen, Tingru Lin, Zhaohui Zhong, Mei Li, Yimeng Yu, Jingzhu Guo, Weidong Yu
BACKGROUND: Increasing evidence suggests that lncRNA (Long non-coding RNA, lncRNA)-mediated ceRNA (competing endogenous RNA, ceRNA) networks are involved in the occurrence and progression of colorectal cancer (CRC). However, the roles of the lncRNA-miRNA-mRNA ceRNA network in distant metastasis of CRC are still unclear. METHODS: In this study, we constructed a specific ceRNA network to identify potential biomarkers and therapeutic targets for distant metastasis of CRC...
December 11, 2023: Cancer Medicine
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