keyword
https://read.qxmd.com/read/38536701/the-milan-score-a-novel-manometric-tool-for-a-more-efficient-diagnosis-of-gastro-esophageal-reflux-disease
#1
JOURNAL ARTICLE
Stefano Siboni, Marco Sozzi, Ivan Kristo, Sara Boveri, Benjamin D Rogers, Nicola De Bortoli, Anthony Hobson, Brian E Louie, Yeong Yeh Lee, Salvatore Tolone, Elisa Marabotto, Pierfrancesco Visaggi, Jordan Haworth, Megan L Ivy, Garrett Greenan, Takahiro Masuda, Roberto Penagini, Benedetta Barcella, Marina Coletta, Dimitrios Theodorou, Tania Triantafyllou, Chiara Facchini, Vincent Tee, Luigi Bonavina, Lorenzo Cusmai, Sebastian F Schoppmann, Edoardo Savarino, Emanuele Asti, C Prakash Gyawali
OBJECTIVE: A definitive diagnosis of gastroesophageal reflux disease (GERD) depends on endoscopic and/or pH-study criteria. However, high resolution manometry (HRM) can identify factors predicting GERD, such as ineffective esophageal motility (IEM), esophago-gastric junction contractile integral (EGJ-CI), evaluating esophagogastric junction (EGJ) type and straight leg raise (SLR) maneuver response. We aimed to build and externally validate a manometric score (Milan Score) to stratify the risk and severity of the disease in patients undergoing HRM for suspected GERD...
March 27, 2024: United European Gastroenterology Journal
https://read.qxmd.com/read/38536601/in-females-salivary-secretion-was-significantly-lower-in-patients-with-severe-reflux-esophagitis-than-in-healthy-controls
#2
JOURNAL ARTICLE
Shintaro Hoshino, Eri Momma, Mai Koeda, Yoshimasa Hoshikawa, Tomohide Tanabe, Noriyuki Kawami, Yuichi Kitasako, Katsuhiko Iwakiri
BACKGROUND: The salivary secretion in patients with mild reflux esophagitis (RE) and non-erosive reflux disease is significantly lower in females, but not in males. However, sex differences in salivary secretion in patients with severe RE remain unknown. Therefore, the present study investigated sex differences in saliva secretion in patients with severe RE. METHODS: Subjects consisted of 23 male patients with severe RE, 24 male healthy controls (HCs), 26 female patients with severe RE, and 25 female HCs...
March 27, 2024: Esophagus: Official Journal of the Japan Esophageal Society
https://read.qxmd.com/read/38528263/risk-factors-associated-with-functional-esophageal-disorders-fed-versus-gastroesophageal-reflux-disease-gerd
#3
JOURNAL ARTICLE
Moniyka Sachar, Marina Wizentier, Emma Risner, Hannah Asmail, Mathew Omara, Shreya Chablaney, Abraham Khan, Rita Knotts
INTRODUCTION: Despite the high prevalence of typical symptoms of gastroesophageal reflux disease (GERD), approximately 30% of patients have functional esophageal disorders (FED) on ambulatory reflux monitoring, which may include reflux hypersensitivity (RH; defined as physiologic acid exposure but temporally correlated symptoms of reflux), or functional heartburn (FH; defined as physiologic acid exposure and negative symptom correlation). There are limited epidemiological data characterizing these conditions...
March 25, 2024: Surgical Endoscopy
https://read.qxmd.com/read/38528208/saliva-production-and-esophageal-motility-influence-esophageal-acid-clearance-related-to%C3%A2-post-reflux-swallow-induced-peristaltic-wave
#4
JOURNAL ARTICLE
Lorenzo Marchetti, Benjamin D Rogers, Tricia Hengehold, Daniel Sifrim, C Prakash Gyawali
BACKGROUND: The post-reflux swallow-induced peristaltic wave (PSPW) brings salivary bicarbonate to neutralize residual distal esophageal mucosal acidification. AIMS: To determine if reduced saliva production and esophageal body hypomotility would compromise PSPW-induced pH recovery in the distal esophagus. METHODS: In this multicenter retrospective cross-sectional study, patients with confirmed Sjogren's syndrome and scleroderma/mixed connective tissue disease (MCTD) who underwent high resolution manometry (HRM) and ambulatory pH-impedance monitoring off antisecretory therapy were retrospectively identified...
March 25, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38526598/development-and-validation-of-the-gastrointestinal-symptom-severity-scale-in-spanish-children-and-adolescents
#5
JOURNAL ARTICLE
Néstor Montoro-Pérez, Agustín Ernesto Martínez-González, Lidia Infante-Cañete, María de Los Ángeles Martínez-González, Silvia Hidalgo-Berutich, Pedro Andreo-Martínez
Functional gastrointestinal disorders (FGIDs) are characterized by chronic or recurrent gastrointestinal symptoms (GS) that are not explained by structural or biochemical abnormalities. FGIDs are related to lower quality of life, increased demands on medical resources, and greater somatization and emotional instability. Furthermore, GS appears to be an indicator of dysbiosis in gut-microbiota, affecting the gut-microbiota-brain relationship. To develop and evaluate the psychometric properties of a new instrument called the Gastrointestinal Symptom Severity Scale (GSSS) using a web-based survey in a sample of neurotypical children and adolescents from Spain...
March 25, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38526305/bovine-aortic-arch-with-an-aberrant-left-vertebral-artery-in-a-3-year-old-boy-with-vacterl-association-a-case-report
#6
JOURNAL ARTICLE
Jesús Martínez-García, Sara F Ordorica-Sandoval, Erick Rivera-Sainz, Manuel A Beltrán-Salas, Nidia León-Sicairos, Adrian Canizalez-Roman
BACKGROUND The VACTEREL association is an acronym that includes vertebral malformations (V), anal atresia (A), cardiac defects (C), tracheoesophageal fistula (TE), renal defects (R), and limb malformations (L). The aortic arch is the section between the ascending aorta and the descending aorta, where some variants have been described, such as the right aortic arch and bovine aortic arch, among others. A rare presentation in the Natsis classification is the "type X" where a bovine aortic arch and anomalous origin of the left vertebral artery are present...
March 11, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38525936/pilot-study-evaluating-salivary-bile-acids-as-a-diagnostic-biomarker-of-laryngopharyngeal-reflux
#7
JOURNAL ARTICLE
Amanda J Krause, Madeline Greytak, Marco Kessler, Rena Yadlapati
Bile acids in refluxate contribute to esophageal and laryngeal symptoms and are quantifiable. The aim of this study was to compare salivary bile acid concentrations across healthy controls and symptomatic patients (esophageal or laryngeal) with or without objective gastroesophageal reflux disease (GERD). This prospective study enrolled adults into three groups: esophageal symptoms (heartburn, regurgitation, chest pain); laryngeal symptoms (cough, throat clearing, sore throat, dysphonia); and controls. Symptomatic patients primarily underwent prolonged wireless reflux monitoring off acid suppression and were categorized as symptomatic no GERD (acid exposure time <4%) or esophageal/laryngeal symptoms with GERD (acid exposure time ≥4%)...
March 24, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38523886/efficacy-and-safety-of-peroral-endoscopic-myotomy-poem-in-achalasia-an-updated-meta-analysis
#8
JOURNAL ARTICLE
Afshin Khaiser, Muhammad Baig, David Forcione, Matthew Bechtold, Srinivas R Puli
Background: Heller myotomy has been considered the standard surgical treatment for patients with achalasia. Since the initiation of peroral endoscopic myotomy (POEM), it has represented an alternative for treating patients with achalasia. Over the years, numerous prospective and retrospective studies with POEM use for achalasia have been published. We performed a systematic review and meta-analysis to evaluate the efficacy and safety of POEM in patients with achalasia. Methods: Publications investigating the safety and efficacy of POEM in patients with achalasia were searched in Medline, Ovid Journals, Medline non-indexed citations, and Cochrane Central Register of Controlled Trials and Database of Systematic Reviews...
October 2023: Middle East Journal of Digestive Diseases
https://read.qxmd.com/read/38523885/predictors-of-pathological-gastroesophageal-reflux-among-emirati-patients-with-reflux-symptoms-who-undergo-wireless-ph-monitoring
#9
JOURNAL ARTICLE
Mostafa Ahmed Shehata, Talaha Aziz Malik, Mona Hassan Jasem Alzaabi, Ameirah Bader Abdullah Al Ali, Khalifa Saleh Ahmed Al Tenaiji, Yashbir Singh, Michael Bradley Wallace
Background: Diagnosis of gastroesophageal reflux disease (GERD) relies on recognizing symptoms of reflux and mucosal changes during esophagogastroduodenoscopy. The desired response to acid suppression therapy is reliable resolution of GERD symptoms; however, these are not always reliable, hence the need for pH testing in unclear cases. Our objective was to identify potential predictors of a high DeMeester score among patients with potential GERD symptoms to identify patients most likely to have pathological GERD...
October 2023: Middle East Journal of Digestive Diseases
https://read.qxmd.com/read/38523834/experience-in-the-treatment-of-long-gap-esophageal-atresia-by-intraluminal-esophageal-stretching-elongation
#10
JOURNAL ARTICLE
Ning Zhang, Wenjie Wu, Yujia Zhuang, Weipeng Wang, Weihua Pan, Jun Wang
OBJECTIVE: To summarize the experience with intraluminal esophageal stretching elongation (ILESE) in the successful treatment of long-gap esophageal atresia (LGEA) at a single center. METHODS: Clinical data of 68 neonates who underwent LGEA between February 2015 and January 2022 were retrospectively analyzed. Four patients died of multiple associated severe malformations and did not undergo ILESE. Esophageal anastomosis was successfully performed in 60 cases (93...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38523356/the-impact-of-lung-transplantation-on-esophageal-motility-and-inter-relationships-with-reflux-and-lung-mechanics-in-patients-with-restrictive-and-obstructive-respiratory-disease
#11
JOURNAL ARTICLE
Ali Alghubari, Ramsah Cheah, Sadia Z Shah, Abdel-Rahman N Naser, Augustine S Lee, Kenneth R DeVault, Lesley A Houghton
BACKGROUND: For many patients with lung disease the only proven intervention to improve survival and quality of life is lung transplantation (LTx). Esophageal dysmotility and gastroesophageal reflux (GER) are common in patients with respiratory disease, and often associate with worse prognosis following LTx. Which, if any patients, should be excluded from LTx based on esophageal concerns remains unclear. Our aim was to understand the effect of LTx on esophageal motility diagnosis and examine how this and the other physiological and mechanical factors relate to GER and clearance of boluses swallowed...
March 24, 2024: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://read.qxmd.com/read/38522850/obesity-and-upper-gastrointestinal-diseases
#12
REVIEW
Younghee Choe
Obesity increases gastroesophageal reflux disease through several factors. As a result, Barrett's esophagus, esophageal adenocarcinoma, and gastroesophageal junctional gastric cancer are increasing. Existing studies usually defined obesity by body mass index and analyzed the correlation. Recently, more studies have shown that central obesity is a more important variable in upper gastrointestinal diseases related to gastroesophageal reflux. Studies have reported that weight loss is effective in reducing gastroesophageal reflux symptoms...
March 25, 2024: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://read.qxmd.com/read/38521967/concurrent-abnormal-non-acid-reflux-is-associated-with-additional-chronic-rejection-risk-in-lung-transplant-patients-with-increased-acid-exposure
#13
JOURNAL ARTICLE
Wai-Kit Lo, Mayssan Muftah, Hilary J Goldberg, Nirmal Sharma, Walter W Chan
Acid reflux has been associated with allograft injury and rejection in lung transplant patients; however, the pathogenic role of non-acid reflux remains debated. We aimed to evaluate the impact of concurrent abnormal non-acid reflux with acid reflux on chronic rejection in lung transplant patients with acid reflux. This was a retrospective cohort study of lung transplant recipients who underwent pre-transplant combined impedance-pH study off acid suppression. Only subjects with acid exposure >4% were included...
March 23, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38519934/perioperative-outcomes-of-the-surgical-management-of-achalasia-in-two-tertiary-cameroonian-hospitals-a-cohort-study
#14
JOURNAL ARTICLE
Joël Igor Kamla, Guy Aristide Bang, Joel Noutakdie Tochie, George Motto Bwelle, Blondel Nana Oumarou, Bernadette Ngo Nonga
INTRODUCTION: Achalasia is a rare esophageal disease with potentially lethal complications. Knowledge of the outcomes of the different surgical treatment modalities for achalasia by Heller's cardiomyotomy (HCM) helps to choose the safest and most effective option. However, data on the management of achalsia using a Heller myotomy is limited in Africa. Thus, our aim was to determine the perioperative morbidity, mortality and short-term functional outcomes of HCM in Cameroon. METHODOLOGY: We conducted a cohort study throughout a 10-year chart review of patients who underwent HCM for achalasia and were followed up postoperatively for at least three months at two tertiary health centers in Cameroon...
March 22, 2024: BMC Gastroenterology
https://read.qxmd.com/read/38518703/esophageal-adenocarcinoma-heterogeneity-in-clinicopathology-and-prognosis-a-single-center-longitudinal-study-of-146-cases-over-a-20-year-period
#15
JOURNAL ARTICLE
Qin Huang, Edward Lew, Yuqing Cheng, Shweta Shinagare, Vikram Deshpande, Jason S Gold, Daniel Wiener, H Christian Weber
Recent genomic studies suggest that esophageal adenocarcinoma (EAC) is not homogeneous and can be divided into true (tEAC) and probable (pEAC) groups. We compared clinicopathologic and prognostic features between the two groups of EAC. Based on endoscopic, radiologic, surgical, and pathologic reports, tumors with epicenters beyond 2 cm of the gastroesophageal junction (GEJ) were assigned to the tEAC group (N = 63), while epicenters within 2 cm of, but not crossing the GEJ, were allocated to the pEAC group (N = 83)...
February 27, 2024: Annals of Diagnostic Pathology
https://read.qxmd.com/read/38516909/pediatric-retrograde-cricopharyngeal-dysfunction-diagnosed-by-high-resolution%C3%A2-impedance-manometry
#16
JOURNAL ARTICLE
Lev Dorfman, Khalil El-Chammas, Sherief Mansi, Kahleb Graham, Ajay Kaul
OBJECTIVES: The inability to burp, known as retrograde cricopharyngeal dysfunction (R-CPD), was initially described in adults. The proposed clinical diagnostic criteria for R-CPD include belching inability, abdominal bloating and discomfort/nausea, postprandial chest pain, and involuntary noises. Botulinum toxin injection to the cricopharyngeal muscle has been reported to be beneficial. High-resolution esophageal impedance-manometry (HRIM) features in adolescent patients with R-CPD have not been described yet...
March 22, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38516311/integrative-effects-of-transcutaneous-auricular-vagus-nerve-stimulation-on-esophageal-motility-and-pharyngeal-symptoms-via-vagal-mechanisms-in-patients-with-laryngopharyngeal-reflux-disease
#17
JOURNAL ARTICLE
Yizhou Huang, Jie Liu, Chaolan Lv, Chenyu Sun, Muzi Meng, Scott Lowe, Yue Yu
BACKGROUND AND AIM: Laryngopharyngeal reflux disease (LPRD) is primarily characterized by discomfort in the pharynx and has limited treatment options. This research aimed to assess the efficacy of transcutaneous auricular vagus nerve stimulation (tVNS) in patients with LPRD and delve into the potential underlying mechanisms. METHODS: A total of 44 participants, diagnosed with LPRD were divided into two groups randomly. Twice-daily stimulation was delivered for 2 weeks for patients in experimental group, with stimulation ranging from 1...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38516244/immunoglobulin-g-mediated-food-intolerance-and-metabolic-syndrome-influence-the-occurrence-of-reflux-esophagitis-in-helicobacter-pylori-infected-patients
#18
JOURNAL ARTICLE
Li-Hui Wang, Bin-Bin Su, Sheng-Shu Wang, Guan-Chao Sun, Kun-Ming Lv, Yi Li, Hui Shi, Qian-Qian Chen
BACKGROUND: Reflux esophagitis has an increasing prevalence and complex and diverse symptoms. Identifying its risk factors is crucial to understanding the etiology, prevention, and management of the disease. The occurrence of reflux esophagitis may be associated with food reactions, Helicobacter pylori ( H. pylori ) infection, and metabolic syndromes. AIM: To investigate the risk factors for reflux esophagitis and analyze the effects of immunoglobulin (Ig) G-mediated food intolerance, H...
February 28, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38513743/risk-of-esophageal-adenocarcinoma-after-helicobacter-pylori-eradication-treatment-in-a-population-based-multinational-cohort-study
#19
JOURNAL ARTICLE
Anna-Klara Wiklund, Giola Santoni, Jane Yan, Cecilia Radkiewicz, Shaohua Xie, Helgi Birgisson, Eivind Ness-Jensen, My von Euler-Chelpin, Joonas H Kauppila, Jesper Lagergren
BACKGROUND & AIMS: Helicobacter pylori infection is associated with a decreased risk of esophageal adenocarcinoma, and the declining prevalence of such infection might contribute to the rising incidence of this tumor. We examined the hypothesis that eradication treatment of Helicobacter pylori increases the risk of esophageal adenocarcinoma. METHODS: This population-based multinational cohort, entitled the "Nordic Helicobacter Pylori Eradication Project (NordHePEP)", included all adults (≥18 years) receiving Helicobacter pylori eradication treatment from 1995-2018 in any of the five Nordic countries (Denmark, Finland, Iceland, Norway, Sweden) with follow-up throughout 2019...
March 19, 2024: Gastroenterology
https://read.qxmd.com/read/38511308/effect-of-intermittent-oro-esophageal-tube-feeding-in-bulbar-palsy-after-ischemic-stroke-a-randomized-controlled-study
#20
JOURNAL ARTICLE
Hongji Zeng, Weijia Zhao, Junfa Wu, Jihong Wei, Heping Li, Liugen Wang, Xi Zeng
BACKGROUND: Nasogastric tube feeding (NG) has been widely used in patients with bulbar palsy after ischemic stroke but is associated with a significant risk of complications including malnutrition and pneumonia. Intermittent oro-esophageal tube feeding (IOE) can help alleviate these concerns. This study explored the clinical effect of IOE versus NG on nutritional status, swallowing function, stroke-associated pneumonia, and depression in patients with bulbar palsy after ischemic stroke...
March 21, 2024: Stroke; a Journal of Cerebral Circulation
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