Munitta Muthana, Aneurin J Kennerley, Russell Hughes, Ester Fagnano, Jay Richardson, Melanie Paul, Craig Murdoch, Fiona Wright, Christopher Payne, Mark F Lythgoe, Neil Farrow, Jon Dobson, Joe Conner, Jim M Wild, Claire Lewis
Cell-based therapy exploits modified human cells to treat diseases but its targeted application in specific tissues, particularly those lying deep in the body where direct injection is not possible, has been problematic. Here we use a magnetic resonance imaging (MRI) system to direct macrophages carrying an oncolytic virus, Seprehvir, into primary and metastatic tumour sites in mice. To achieve this, we magnetically label macrophages with super-paramagnetic iron oxide nanoparticles and apply pulsed magnetic field gradients in the direction of the tumour sites...
August 18, 2015: Nature Communications