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Ban Leong Sng, Yanzhi Zeng, Nurun Nisa A de Souza, Wan Ling Leong, Ting Ting Oh, Fahad Javaid Siddiqui, Pryseley N Assam, Nian-Lin R Han, Edwin Sy Chan, Alex T Sia
BACKGROUND: Childbirth may cause the most severe pain some women experience in their lifetime. Epidural analgesia is an effective form of pain relief during labour and is considered to be the reference standard. Traditionally epidural analgesia has been delivered as a continuous infusion via a catheter in the epidural space, with or without the ability for the patient to supplement the analgesia received by activating a programmable pump to deliver additional top-up doses, known as patient-controlled epidural analgesia (PCEA)...
May 17, 2018: Cochrane Database of Systematic Reviews
Lindy Clemson, Lynette Mackenzie, Chris Roberts, Roslyn Poulos, Amy Tan, Meryl Lovarini, Cathie Sherrington, Judy M Simpson, Karen Willis, Mary Lam, Anne Tiedemann, Dimity Pond, David Peiris, Sarah Hilmer, Sabrina Winona Pit, Kirsten Howard, Lorraine Lovitt, Fiona White
BACKGROUND: Despite strong evidence giving guidance for effective fall prevention interventions in community-residing older people, there is currently no clear model for engaging general medical practitioners in fall prevention and routine use of allied health professionals in fall prevention has been slow, limiting widespread dissemination. This protocol paper outlines an implementation-effectiveness study of the Integrated Solutions for Sustainable Fall Prevention (iSOLVE) intervention which has developed integrated processes and pathways to identify older people at risk of falls and engage a whole of primary care approach to fall prevention...
February 7, 2017: Implementation Science: IS
Aysegul Hanikoglu, Ferhat Hanikoglu, Tomris Ozben
Acetylation and deactylation of histones are important determinants of gene expression. Histone deacetylases (HDACs) remove acetyl groups from histones leading to suppression and regulation of epigenetic gene expression. Current studies have demonstrated that HDAC-inhibitors (HDACIs) inducing histone hyperacetylation are promising novel agents in cancer treatment. HDACIs have been shown to have significant anticancer effects with negligible toxicity in the preclinical studies. Ongoing clinial trials are being performed to investigate the efficiency of HDACIs in human cancers...
2018: Current Protein & Peptide Science
Zhibin Wang, Xiao-Guang Luo, Chao Gao
In the clinic, the diagnosis of Parkinson's disease (PD) largely depends on clinicians' experience. When the diagnosis is made, approximately 80% of dopaminergic cells in the substantia nigra (SN) have been lost. Additionally, it is rather challenging to differentiate PD from atypical parkinsonian disorders (APD). Clinially-available 3T conventional MRI contributes little to solve these problems. The pathologic alterations of parkinsonism show abnormal brain iron deposition, and therefore susceptibility-weighted imaging (SWI), which is sensitive to iron concentration, has been applied to find iron-related lesions for the diagnosis and differentiation of PD in recent decades...
2016: Translational Neurodegeneration
Xiao-Yang Hao, Lin-Hong Wang, Yan-Yan Xie, Wen-Yue Qi, Song Zhang, Mei-Rong Yang, Zhen-Yu Yan, Nai-Yao Chen
OBJECTIVE: To investigate the influencing factors and pathogenesis of osteopenia in the patients with hemophilia. METHODS: Twenty-three patients with hemophilia were admitted in the hospital affiliated to North China University of Science and technology from March to August 2015, including 13 severe cases, 10 mild and moderate cases. All the patients accepted the detection of serum I collagen cross-linking N terminal peptide (NTX I), osteoprotegerin (OPG), bone alkaline phosphatase (BALP), basic fibroblast growth factor (bFGF), insulin-like growth factor (IGF) and transforming growth factor-β1 (TGF-β1), the score scale of activity ability was recorded according to the criteria published by the U...
June 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
Luis Fernández Salazar, Jesús Barrio Andrés, Fernando Muñoz, Concepción Muñoz Rosas, Ramón Pajares Villarroya, Montserrat Rivero Tirado, Vanessa Prieto Vicente, Jesús Legido Gil, Abdel Bouhmidi, Maite Herranz, Guillermo González Redondo, Nereida Fernández Fernández, Fernando Santos Santamarta, Ramón Sánchez Ocaña, Diana Joao Matias
INTRODUCTION: IFX therapy intensification in UC is more common than established in pivotal studies. OBJECTIVES: To establish the frequency and form of intensification for UC in clinial practice, as well as predictors, and to compare outcomes between intensified and non-intensified treatment. METHODS: A retrospective study of 10 hospitals and 144 patients with response to IFX induction. Predictive variables for intensification were analyzed using a Cox regression analysis...
July 6, 2015: Revista Española de Enfermedades Digestivas
Zsolt Dubravcsik, Gyula Farkas, Péter Hegyi, István Hritz, Dezső Kelemen, Natália Lásztity, Zita Morvay, Attila Oláh, Ákos Pap, Andrea Párniczky, Miklós Sahin-Tóth, Zsolt Szentkereszti, Richárd Szmola, Tamás Takács, László Tiszlavicz, Ákos Szücs, László Czakó
Autoimmune pancreatitis is a rare disease which can even mimic pancreatic tumor, however, unlike the latter, it requires not surgical but conservative management. Correct diagnosis and differential diagnosis of autoimmune pancreatitis and treatment of these patients requires up-to-date and evidence based management guidelines. The Hungarian Pancreatic Study Group proposed to prepare an evidence based guideline based on the available international guidelines and evidences. The preparatory and consultation task force appointed by the Hungarian Pancreatic Study Group translated and complemented and/or modified the international guidelines if it was necessary...
February 22, 2015: Orvosi Hetilap
Tamás Takács, László Czakó, Zsolt Dubravcsik, Gyula Farkas, Péter Hegyi, István Hritz, Dezső Kelemen, Natália Lásztity, Zita Morvay, Attila Oláh, Ákos Pap, Andrea Párniczky, Árpád Patai, Miklós Sahin-Tóth, Zsolt Szentkereszti, Richárd Szmola, László Tiszlavicz, Ákos Szücs
Chronic pancreatitis is an inflammatory disease associated with structural and functional damage of the pancreas. In most cases pain, maldigestion and weight loss are the leading symptoms, which significantly worsen the quality of life. Correct diagnosis and differential diagnosis of chronic pancreatitis and treatment of these patients requires up-to-date and evidence based treatment guidelines. The Hungarian Pancreatic Study Group proposed to prepare an evidence based guideline based on the available international guidelines and evidence...
February 15, 2015: Orvosi Hetilap
Kimihiro Okubo
No abstract text is available yet for this article.
December 2014: Arerugī, [Allergy]
Si-Hoon Son, Seok-Won Chung, Kyoung-Tae Kim, Dae-Chul Cho
Back pain and radiating pain to the legs are the most common symptoms encountered in routine neurosurgical practice and usually originates from neurogenic causes including spinal stenosis. The clinial symptoms are often confused with symptoms of peripheral neuropathy, musculo-skeletal disease and vascular disease in elderly patients. Because it is not easy to distinguish out the cause of symptoms by only physical examination, routine spinal MRI is checked first to rule out the spinal diseases in most outpatient clinics...
December 2013: Korean Journal of Spine
Ajediran I Bello, Eric K Ofori, Oluwasegun J Alabi, David N Adjei
BACKGROUND: Objective physical assessment of patients with lumbar spondylosis involves plain film radiographs (PFR) viewing and interpretation by the radiologists. Physiotherapists also routinely assess PFR within the scope of their practice. However, studies appraising the level of agreement of physiotherapists' PFR interpretation with radiologists are not common in Ghana. METHOD: Forty-one (41) physiotherapists took part in the cross-sectional survey. An assessment guide was developed from findings of the interpretation of three PFR of patients with lumbar spondylosis by a radiologist...
March 29, 2014: BMC Medical Imaging
Heidi J Kalkwarf, Steven A Abrams, Linda A DiMeglio, Winston W K Koo, Bonny L Specker, Hope Weiler
Infants and children <5 yr were not included in the 2007 International Society for Clinical Densitometry Official Positions regarding Skeletal Health Assessment of Children and Adolescents. To advance clinical care of very young children, the International Society for Clinical Densitometry 2013 Position Development Conference reviewed the literature addressing appropriate methods and skeletal sites for clinical dual-energy X-ray absorptiometry (DXA) measurements in infants and young children and how results should be reported...
April 2014: Journal of Clinical Densitometry
Ana Paula Grotti Clemente, Bárbara Dal Molin Netto, Aline di Piano Ganen, Lian Tock, Danielle Arisa Caranti, Marco Túlio de Mello, Sergio Tufik, Ana R Dâmaso
Objectives. The present study aimed at determining cut-off points of visceral fat to predict NAFLD and analyzed metabolic disorders of obese adolescents. Methods. Cross-sectional study involved 165 obese adolescents ranged in age from 15 to 19 years. Glycemia, hepatic transaminases, lipid profile, and insulin resistance were analyzed. Visceral and subcutaneous fat were measured by ultrasound and body composition by plesthysmography. Results. The NAFLD adolescents had significantly higher values for body mass, BMI-for-age, BMI, total fat, waist circumference, and visceral fat when compared with non-NAFLD obese adolescents in both genders...
2013: Journal of Nutrition and Metabolism
Roger S Lo, Hubing Shi
(V600)BRAF mutation was identified as an ideal target for clinical therapy due to its indispensable roles in supporting melanoma initiation and progression. Despite the fact that BRAF inhibitors (BRAFi) can elicit anti-tumor responses in the majority of treated patients and confer overall survival benefits, acquired drug resistance is a formidable obstacle to long-term management of the disease. Several aberrant events including RTK upregulation, NRAS mutation, mutant BRAF amplification or alternative splicing, and MEK mutation have been reported as acquired BRAFi resistance mechanisms...
2014: Methods in Molecular Biology
Shoichi Onodera, Yasuhiko Onoe, Takahide Hosobe, Tetsuro Kato, Masaki Yoshida
We investigated the efficacy and safety of levofloxacin (LVFX) 500mg once a day in patients with non-gonorrheal urethritis. Men, aged 20 years or older, with urethritis symptoms, and detection of Chlamydia trachomatis (C. trachomatis) or Mycoplasma genitalium (M. genitalium) by a microbiological examination were eligible for this study. Patients were administered LVFX 500mg, orally, once a day and the dosage period was seven days. We assumed 22 patients for a safety and efficacy analysis. In 22 patients, 17 patients had urethritis with C...
December 2012: Japanese Journal of Antibiotics
Emese Kiss, Judit Dohán, János Németh, Gyula Poór
Behcet's disease is a multisystem autoimmune disease with variable clinial manifestations. The diagnosis may pose a difficult challenge for the clinician, who has to be familiar with the wide spectrum and combination of the symptoms of Behcet's disease. It is considered a rare disease in Hungary, and there are only few reports on Behcet's disease in the Hungarian literature. However, the past history of Hungary, the worldwide growing incidence of the disease, and the authors' experience raise the possibility that the occurrence of the disease is higher than previously thought...
January 20, 2013: Orvosi Hetilap
M Andratschke, J Lörken, R Eggers, R Magritz, R Siegert, B Wollenberg
BACKGROUND: Initial results on the application of the water-jet in a parotidectomy setting in an animal study demonstrate that there are morphologic changes which do, and some which do not, affect the clinial function of the facial nerve due to the different jet sizes and operating pressures used. In a further study the histomorphometric data of the facial nerve dissected by the water-jet should be evaluated and correlated to the different sizes of jet and operating pressures. MATERIAL AND METHODS: In total, 102 nerves (in 14 beagles) which had been dissected by water-jets of different sizes and operating pressures were evaluated...
October 2011: HNO
K M Prasad, K N Sreenivas, M V Ashok, D Bagchi
This retrospective study aimed to explore the sociodemographic and clinial profile of patients aged 60 years and above attending the psychiatric services of NIMHANS. Two hundred and sixty-five such patients utilized the services during one year. Preliminary analysis of the data revealed that nearly three-fourths of the patients were between 60 and 69 years of age. The family support was adequate for most of the patients. Psychoses made up two-thirds of the sample (nonorganic psychoses = 43% and organic psychoses = 22%)...
July 1996: Indian Journal of Psychiatry
S Malhotra, V M Aga, Balraj, N Gupta
In a retrospective descriptive study of hyperkinetic conduct disorders (HCD) and conduct disorders (CD), as per ICD-10 diagnostic criteria, their clinical and phenomenological correlates were compared; with an aim of describing their distinctive clinical profiles. 20 cases of HCD and 25 cases of CD were compared on socio-demographic variables, temperament and specified clinical variables. The two groups differed in terms of the HCD group having younger age of onset, a more gradual development of and longer duration of conduct symptoms as compared to CD children...
April 1999: Indian Journal of Psychiatry
Peter Rickenbacher
Based on multiple randomized controlled trials performed in the last 20 years, drugs form the basis of treatment for heart failure with reduced ejection fraction (HFREF). Despite solid evidence for their efficacy and safety and publication of detailed national and international guidelines many patients with HFREF remain, who are not at all or only insufficiently treated. Treatment goals include reduction of mortality and hospitalizations, improvement of symptoms and exercise tolerance as well as prevention of disease progression...
February 2011: Therapeutische Umschau. Revue Thérapeutique
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