keyword
https://read.qxmd.com/read/38537202/significantly-elevated-fdg-activity-in-neurothekeoma
#21
JOURNAL ARTICLE
Raisa Amiruddin, Hongming Zhuang
Neurothekeoma is a very rare cutaneous lesion affecting mainly young patients. The lesion is generally benign. We report here that intense FDG activity on PET/CT was noted at the site of primary neurothekeoma of the right shoulder in a 16-year-old boy. Abnormal FDG activity was also seen in the metastatic neurothekeoma in the lung in the same patient 2 years later.
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38537201/prospective-evaluation-of-serum-free-thiols-in-inflammatory-bowel-disease-a-candidate-to-replace-c-reactive-protein-for-disease-activity-assessment
#22
JOURNAL ARTICLE
Anuj Bohra, Nicholas Batt, Krishneel Dutt, Pavel Sluka, Olga Niewiadomski, Abhinav Vasudevan, Daniel R Van Langenberg
BACKGROUND: Serum free thiols (SFTs) reflecting oxidative stress appear to correlate with inflammatory bowel disease (IBD) activity. We aimed to evaluate the performance of SFTs concentrations vs endoscopic and histological activity, compare SFTs with established biomarkers, and identify clinical and laboratory parameters independently associated with SFT levels in IBD patients. METHODS: Patients with confirmed IBD undergoing routine ileocolonoscopy for activity assessment were prospectively recruited, with serum samples obtained concurrently for SFTs and routine bloods, plus fecal calprotectin and immunochemical tests were collected ±30 days from ileocolonoscopy...
March 27, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38537186/can-the-width-of-lower-tongue-base-preoperative-sonography-measurements-predict-hypoxemia-during-esophagogastroduodenoscopy-under-sedation-in-asa-i-ii-patients
#23
JOURNAL ARTICLE
Hao Wu, Min Xia, Xu Chen, Sheng Wang, Wei Zhang
The most common complication during esophagogastroduodenoscopy (EGD) under sedation is hypoxemia. There is a scarcity of indicators to predict the risk of hypoxemia during EGD under sedation accurately. The width of the lower tongue base measured by ultrasound (US) is considered to be a significant predictor of the presence and severity of obstructive sleepapnea syndrome (OSAS), which develops hypoxemia by a similar mechanism to EGD under sedation. This study aimed to observe its ability to predict hypoxemia during EGD under sedation...
January 30, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38537185/influence-of-body-mass-normalization-on-the-correlations-between-muscle-cross-sectional-area-and-physical-performance-outcomes-in-older-women
#24
JOURNAL ARTICLE
Ty B Palmer, Bailey M Palmer
AIMS: Normalization is a method used to account for body mass in clinical practice and research. It is unclear if this method will improve the correlation between muscle cross-sectional area (CSA) and physical performance. We examined the correlations between quadriceps muscle morphology parameters and physical performance outcomes in older women. Material and methods: Twenty older women participated in this study. Ultrasound imaging was used to measure quadriceps muscle CSA and echo intensity...
January 30, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38537183/a-radiomics-model-based-on-transrectal-ultrasound-for-predicting-prostate-cancer
#25
JOURNAL ARTICLE
Yanhua Huang, Hongwei Qian, Yuanyuan Zheng, Huiming Song, Xiatian Liu
AIM: Prostate cancer (PCa) is one of the most common neoplasms in men. However, the value of ultrasound-based radiomics for diagnosing PCa remains uncertain. MATERIAL AND METHODS: We retrospectively analyzed ultrasonic and clinical data from 373 patients. Patients were divided into two groups according to the pathological results. Radiomics features wereextracted from TRUS, and we screened the optimal features to construct radiomics models. Relationships between clinical characteristics and prostate lesions were identified by univariate and multivariate logistic regression analysis...
February 7, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38537182/diagnostic-and-prognostic-efficacy-of-optic-nerve-sheath-diameter-in-patients-with-dysnatremia
#26
JOURNAL ARTICLE
Berika Kavaz Kuru, Ahmet Baydın, Metin Ocak, İskender Aksoy
AIM: This study aimed to investigate the diagnostic and prognostic value of optic nerve sheath diameter (ONSD) measurement in patients with dysnatremia. MATERIAL AND METHODS: This prospective clinical study included patients aged ≥18 years who were diagnosed with dysnatremia on admission to the emergency department. RESULTS: The present study included 65 patients (35 with hypernatremia [hypernatremia group] and 30 with hyponatremia [hyponatremia group]) and 14 healthy volunteers (control group)...
February 13, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38537177/an-unexpected-seminal-vesicle-pitfall-in-psma-pet
#27
JOURNAL ARTICLE
Angela Bronte, Juan J Rosales, Marcos Torres Roca, Bernardino Miñana, Macarena Rodríguez-Fraile
A 76-year-old man undergoing hormone therapy for prostate cancer was referred for 68Ga-PSMA-11-PET (PSMA PET) due to persistently detectable PSA level. No PSMA-positive tumor lesions were detected, so a delayed phase imaging was performed, which revealed focal PSMA uptake in the right seminal vesicle together with contrast accumulation on excretory phase contrast-enhanced CT. These findings were finally determined to be secondary to urinary reflux as a consequence of a prostatic enucleation he had undergone 5 months earlier following an episode of acute urinary retention...
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38537161/serum-hsp70-and-vegf-levels-are-effective-predictive-factors-of-chemoradiosensitivity-and-prognosis-of-pancreatic-cancer-patients
#28
JOURNAL ARTICLE
Liumei Xiong, Danming Li, Gui Xiao, Sipin Tan, Jianbo Wen, Guiliang Wang
AIM: To evaluate the value of serum HSP70 and VEGF levels for predicting the chemoradiosensitivity of the pancreatic cancer patients. METHODS: A total of 255 patients with pancreatic cancer and 60 healthy subjects were enrolled in this study. Serum levels of HSP70 and VEGF were measured using enzyme-linked immunosorbent assay (ELISA) for the pre-treatment, during-treatment and post- chemoradiotherapy time-points. The results were analyzed to evaluate the potential of serum HSP70 and VEGF levels for predicting the chemoradiosensitivity of pancreatic cancer patients...
March 27, 2024: Pancreas
https://read.qxmd.com/read/38537159/pack-year-smoking-history-an-inadequate-and-biased-measure-to-determine-lung-cancer-screening-eligibility
#29
JOURNAL ARTICLE
Alexandra L Potter, Nuo N Xu, Priyanka Senthil, Deepti Srinivasan, Hang Lee, G Scott Gazelle, Lydia Chelala, Wei Zheng, Florian J Fintelmann, Lecia V Sequist, Jessica Donington, Julie R Palmer, Chi-Fu Jeffrey Yang
PURPOSE: Pack-year smoking history is an imperfect and biased measure of cumulative tobacco exposure. The use of pack-year smoking history to determine lung cancer screening eligibility in the current US Preventive Services Task Force (USPSTF) guideline may unintentionally exclude many high-risk individuals, especially those from racial and ethnic minority groups. It is unclear whether using a smoking duration cutoff instead of a smoking pack-year cutoff would improve the selection of individuals for screening...
March 27, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38537158/impact-of-broadening-trial-eligibility-criteria-on-the-inclusion-of-patients-with-brain-metastases-in-cancer-clinical-trials-time-series-analyses-for-2012-2022
#30
JOURNAL ARTICLE
Hong Xiao, Riha Vaidya, Dawn L Hershman, Joseph M Unger
PURPOSE: In October 2017, an ASCO, Friends of Cancer Research (FoCR), and US Food and Drug Administration (ASCO/FoCR/FDA) task force recommended that common eligibility criteria be modified to make trials more inclusive. We examined whether patterns of exclusions regarding patients with brain metastases changed over time in relation to these recommendations. METHODS: Trial eligibility criteria were abstracted from ClinicalTrials.gov for phase I-III US-based interventional clinical trials for patients with advanced breast, colorectal, lung, or melanoma cancers from January 2012 to December 2022...
March 27, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38537157/toward-racial-equity-in-lung-cancer-screening-eligibility
#31
EDITORIAL
Hasmeena Kathuria, Renda Soylemez Wiener
No abstract text is available yet for this article.
March 27, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38537156/female-specific-health-care-of-military-female-designated-service-members-and-veterans-a-systematic-overview-of-reviews
#32
JOURNAL ARTICLE
Megan C McDermott, Megan G Musilli, Jill E Brown, John L Melton, Michael J Miller, Rhonda J Allard, Monica A Lutgendorf
INTRODUCTION: Since the War in Afghanistan began in 2001, service members have faced significant health effects related to service during war, with female-designated service members facing unique challenges. Numerous high-quality review articles have been published on the health and care of female-designated service members and veterans. Given the increasing volume of literature, we completed an overview of reviews on the health and health care of female-designated military populations...
March 27, 2024: Military Medicine
https://read.qxmd.com/read/38537155/giredestrant-for-estrogen-receptor-positive-her2-negative-previously-treated-advanced-breast-cancer-results-from-the-randomized-phase-ii-acelera-breast-cancer-study
#33
JOURNAL ARTICLE
Miguel Martín, Elgene Lim, Mariana Chavez-MacGregor, Aditya Bardia, Jiong Wu, Qingyuan Zhang, Zbigniew Nowecki, Felipe Melo Cruz, Rustem Safin, Sung-Bae Kim, Christian Schem, Alberto J Montero, Sarah Khan, Reeti Bandyopadhyay, Heather M Moore, Mahesh Shivhare, Monika Patre, Jorge Martinalbo, Laura Roncoroni, Pablo Diego Pérez-Moreno, Joohyuk Sohn
PURPOSE: To compare giredestrant and physician's choice of endocrine monotherapy (PCET) for estrogen receptor-positive, HER2-negative, advanced breast cancer (BC) in the phase II acelERA BC study (ClinicalTrials.gov identifier: NCT04576455). METHODS: Post-/pre-/perimenopausal women, or men, age 18 years or older with measurable disease/evaluable bone lesions, whose disease progressed after 1-2 lines of systemic therapy (≤1 targeted, ≤1 chemotherapy regimen, prior fulvestrant allowed) were randomly assigned 1:1 to giredestrant (30 mg oral once daily) or fulvestrant/aromatase inhibitor per local guidelines (+luteinizing hormone-releasing hormone agonist in pre-/perimenopausal women, and men) until disease progression/unacceptable toxicity...
March 27, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38537153/novel-proteomic-signatures-may-indicate-mri-assessed-intrahepatic-fat-state-and-changes-the-direct-plus-clinical-trial
#34
JOURNAL ARTICLE
Dana T Goldberg, Anat Yaskolka Meir, Gal Tsaban, Ehud Rinott, Alon Kaplan, Hila Zelicha, Nora Klöting, Uta Ceglarek, Berend Iserman, Ilan Shelef, Philip Rosen, Matthias Blüher, Michael Stumvoll, Ohad Etzion, Meir J Stampfer, Frank B Hu, Iris Shai
OBJECTIVE: We demonstrated in the randomized 18-month DIRECT PLUS trial (n=294) that a Mediterranean (MED) diet, supplemented with polyphenol-rich Mankai duckweed, green tea, and walnuts and restricted in red/processed meat, caused substantial intrahepatic fat (IHF%) loss compared with two other healthy diets, reducing NAFLD by half, regardless similar weight loss. Here, we investigated the baseline proteomic profile associated with IHF% and the changes in proteomics associated with IHF% changes induced by lifestyle intervention...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537150/prediction-of-occult-hemorrhage-in-the-lower-body-negative-pressure-model-initial-validation-of-machine-learning-approaches
#35
JOURNAL ARTICLE
Navid Rashedi, Yifei Sun, Vikrant Vaze, Parikshit Shah, Ryan Halter, Jonathan T Elliott, Norman A Paradis
INTRODUCTION: Detection of occult hemorrhage (OH) before progression to clinically apparent changes in vital signs remains an important clinical problem in managing trauma patients. The resource-intensiveness associated with continuous clinical patient monitoring and rescue from frank shock makes accurate early detection and prediction with noninvasive measurement technology a desirable innovation. Despite significant efforts directed toward the development of innovative noninvasive diagnostics, the implementation and performance of the newest bedside technologies remain inadequate...
March 27, 2024: Military Medicine
https://read.qxmd.com/read/38537134/nk-cell-elicited-gasdermin-d-dependent-hepatocyte-pyroptosis-induces-neutrophil-extracellular-traps-that-facilitates-hbv-related-acute-on-chronic-liver-failure
#36
JOURNAL ARTICLE
Qiang Zhao, Dong-Ping Chen, Hua-Di Chen, Ying-Zhe Wang, Wei Shi, Yi-Tong Lu, Yi-Zheng Ren, Yuan-Kai Wu, Yi-Hua Pang, Hong Deng, Xiaoshun He, Dong-Ming Kuang, Zhi-Yong Guo
BACKGROUND AIMS: Hepatitis B virus (HBV) infection is a major etiology of acute-on-chronic liver failure (ACLF). At present, the pattern and regulation of hepatocyte death during HBV-ACLF progression are still undefined. Evaluating the mode of cell death and its inducers will provide new insights for developing therapeutic strategies targeting cell death. In this study, we aimed to elucidate whether and how immune landscapes trigger hepatocyte death and lead to the progression of HBV-related ACLF...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537130/comprehensive-molecular-classification-predicted-microenvironment-profiles-and-therapy-response-for-hepatocellular-carcinoma
#37
JOURNAL ARTICLE
Yihong Chen, Xiangying Deng, Yin Li, Ying Han, Yinghui Peng, Wantao Wu, Xinwen Wang, Jiayao Ma, Erya Hu, Xin Zhou, Edward Shen, Shan Zeng, Changjing Cai, Yiming Qin, Hong Shen
BACKGROUND AND AIMS: Tumor microenvironment (TME) heterogeneity leads to a discrepancy in survival prognosis and clinical treatment response for hepatocellular carcinoma (HCC) patients. The clinical applications of documented molecular subtypes are constrained by several issues. APPROACH AND RESULTS: We integrated three single-cell datasets to describe the TME landscape and identified six prognosis-related cell subclusters. Unsupervised clustering of subcluster-specific markers was performed to generate transcriptomic subtypes...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537129/the-association-between-mean-arterial-pressure-and-acute-kidney-injury-reversal-among-decompensated-cirrhosis-patients
#38
JOURNAL ARTICLE
Giuseppe Cullaro, Andrew S Allegretti, Cynthia Fenton, Jin Ge, Kavish R Patidar, Jessica Rubin, Arjun Sharma, Jennifer C Lai
BACKGROUND: This study informs how mean arterial pressure (MAP) impacts AKI recovery among all patients hospitalized with cirrhosis, regardless of etiology. METHODS: We identified incident AKI episodes among subjects in our cohort of decompensated cirrhosis patients. AKI was defined as a ≥50% increase in creatinine (sCr) from an outpatient baseline (≥7 days prior) that required hospitalization. Linear mixed-effects models were completed to determine the impact between AKI recovery, MAP, and time...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537123/excitatory-cerebellar-transcranial-direct-current-stimulation-boosts-the-leverage-of-prior-knowledge-for-predicting-actions
#39
JOURNAL ARTICLE
Viola Oldrati, Niccolò Butti, Elisabetta Ferrari, Zaira Cattaneo, Cosimo Urgesi, Alessandra Finisguerra
The cerebellum causally supports social processing by generating internal models of social events based on statistical learning of behavioral regularities. However, whether the cerebellum is only involved in forming or also in using internal models for the prediction of forthcoming actions is still unclear. We used cerebellar transcranial Direct Current Stimulation (ctDCS) to modulate the performance of healthy adults in using previously learned expectations in an action prediction task. In a first learning phase of this task, participants were exposed to different levels of associations between specific actions and contextual elements, to induce the formation of either strongly or moderately informative expectations...
February 28, 2024: Social Cognitive and Affective Neuroscience
https://read.qxmd.com/read/38537119/constructing-linear-oriented-pre-vascularized-human-spinal-cord-tissues-for-spinal-cord-injury-repair
#40
JOURNAL ARTICLE
Caixia Fan, Hui Cai, Lulu Zhang, Xianming Wu, Junyan Yan, Lifang Jin, Baowei Hu, Jiaxiong He, Yanyan Chen, Yannan Zhao, Jianwu Dai
Repairing spinal cord injury (SCI) is a global medical challenge lacking effective clinical treatment. Developing human-engineered spinal cord tissues that can replenish lost cells and restore a regenerative microenvironment offers promising potential for SCI therapy. However, creating vascularized human spinal cord-like tissues that mimic the diverse cell types and longitudinal parallel structural features of spinal cord tissues remains a significant hurdle. In present study, vascularized spinal cord tissues (VSCT) were engineered using embryonic human spinal cord-derived neural cells and endothelial cells on linear ordered collagen scaffolds (LOCS)...
March 27, 2024: Advanced Healthcare Materials
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