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REVIEW
Hans-Jörg Busch, Sebastian Wolfrum, Guido Michels, Matthias Baumgärtel, Klaus-Friedrich Bodmann, Michael Buerke, Volker Burst, Philipp Enghard, Georg Ertl, Wolf Andreas Fach, Frank Hanses, Hans Jürgen Heppner, Carsten Hermes, Uwe Janssens, Stefan John, Christian Jung, Christian Karagiannidis, Michael Kiehl, Stefan Kluge, Alexander Koch, Matthias Kochanek, Peter Korsten, Philipp M Lepper, Martin Merkel, Ursula Müller-Werdan, Martin Neukirchen, Alexander Pfeil, Reimer Riessen, Wolfgang Rottbauer, Sebastian Schellong, Alexandra Scherg, Daniel Sedding, Katrin Singler, Marcus Thieme, Christian Trautwein, Carsten Willam, Karl Werdan
In Germany, physicians qualify for emergency medicine by combining a specialty medical training-e.g. internal medicine-with advanced training in emergency medicine according to the statutes of the State Chambers of Physicians largely based upon the Guideline Regulations on Specialty Training of the German Medical Association. Internal medicine and their associated subspecialities represent an important column of emergency medicine. For the internal medicine aspects of emergency medicine, this curriculum presents an overview of knowledge, skills (competence levels I-III) as well as behaviours and attitudes allowing for the best treatment of patients...
April 16, 2024: Medizinische Klinik, Intensivmedizin und Notfallmedizin
#2
JOURNAL ARTICLE
Karl Knipper, Thaddaeus Krey, Su Ir Lyu, Jin-On Jung, Naita M Wirsik, Hans F Fuchs, Wolfgang Schröder, Hans A Schlößer, Felix C Popp, Alexander Quaas, Christiane J Bruns, Thomas Schmidt
PURPOSE: Patients with local recurrence of esophageal cancer have a highly decreased overall survival. There is currently no standardized treatment algorithm for this group. This retrospective cohort study aimed to evaluate the survival of patients with local recurrence, despite receiving individualized treatment options. METHODS: 241 of 1791 patients were diagnosed with a local recurrence following Ivor-Lewis esophagectomy at the University Hospital of Cologne...
March 30, 2024: World Journal of Surgery
#3
JOURNAL ARTICLE
Exploring sleep duration and clinical reasoning process in resident physicians: a thematic analysis.
Jacob Collen, Steven Durning, Joshua Berk, Josef Mang, Karl Alcover, Eulho Jung
STUDY OBJECTIVES: Connecting resident physician work hours and sleep deprivation to adverse outcomes has been difficult. Our study explores clinical reasoning rather than outcomes. Diagnostic errors are a leading cause of medical error and may result from deficits in clinical reasoning. We used simulated cases to explore relationships between sleep duration and diagnostic reasoning. METHODS: Residents were recruited for a 2-month study (inpatient/outpatient). Each participant's sleep was tracked (sleep diary/actigraphy)...
March 28, 2024: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
#4
JOURNAL ARTICLE
Jesper Tessin, Arne Jung, Amanda Silberborth, Karl Rohn, Jochen Schulz, Christian Visscher, Nicole Kemper
Worldwide outbreaks make infections with pathogenic strains of Enterococcus cecorum (EC) one of the most important diseases in the broiler industry. Although research has increased knowledge about the pathogen, the transmission is not fully understood. Samples from different locations were collected from two broiler farms in Germany over a total of six production cycles. Samples were collected at days 1, 5, 10, 15, 21, 27, 34, 41 post-hatch and after cleaning and disinfection (C&D). A total of 1017 samples were collected from 25 different locations on the farms...
March 25, 2024: Avian Pathology: Journal of the W.V.P.A
#5
Xiangnan Guan, Ruozhen Hu, Yoonha Choi, Shyam Srivats, Barzin Y Nabet, John Silva, Lisa McGinnis, Robert Hendricks, Katherine Nutsch, Karl L Banta, Ellen Duong, Alexis Dunkle, Patrick S Chang, Chia-Jung Han, Stephanie Mittman, Nandini Molden, Pallavi Daggumati, Wendy Connolly, Melissa Johnson, Delvys Rodriguez Abreu, Byoung Chul Cho, Antoine Italiano, Ignacio Gil-Bazo, Enriqueta Felip, Ira Mellman, Sanjeev Mariathasan, David S Shames, Raymond Meng, Eugene Y Chiang, Robert J Johnston, Namrata S Patil
No abstract text is available yet for this article.
March 13, 2024: Nature
#6
JOURNAL ARTICLE
Maxim Privalov, Malte Junge, Matthias Karl Jung, Sven Yves Vetter, Jochen Franke, Svetlana Hetjens, Paul Alfred Grützner, Holger Stadthalter
BACKGROUND: Type C pelvic fractures (AO/OTA) are severe injuries that frequently lead to bleeding and hemodynamic instability. Pelvic binders play a crucial role in their initial management. Placement at the correct level in the prehospital setting is challenging. The aim of this study was to compare two pelvic binders regarding their effectiveness in reducing intrapelvic volume and increasing intrapelvic pressure in patients with type C pelvic fractures (AO/OTA) when applied at three different levels...
March 4, 2024: International Journal of Emergency Medicine
#7
JOURNAL ARTICLE
Xiangnan Guan, Ruozhen Hu, Yoonha Choi, Shyam Srivats, Barzin Y Nabet, John Silva, Lisa McGinnis, Robert Hendricks, Katherine Nutsch, Karl L Banta, Ellen Duong, Alexis Dunkle, Patrick S Chang, Chia-Jung Han, Stephanie Mittman, Nandini Molden, Pallavi Daggumati, Wendy Connolly, Melissa Johnson, Delvys Rodriguez Abreu, Byoung Chul Cho, Antoine Italiano, Ignacio Gil-Bazo, Enriqueta Felip, Ira Mellman, Sanjeev Mariathasan, David S Shames, Raymond Meng, Eugene Y Chiang, Robert J Johnston, Namrata S Patil
Tiragolumab, an anti-TIGIT antibody with an active IgG1κ Fc, demonstrated improved outcomes in the phase 2 CITYSCAPE trial (ClinicalTrials.gov: NCT03563716 ) when combined with atezolizumab (anti-PD-L1) versus atezolizumab alone1 . However, there remains little consensus on the mechanism(s) of response with this combination2 . Here we find that a high baseline of intratumoural macrophages and regulatory T cells is associated with better outcomes in patients treated with atezolizumab plus tiragolumab but not with atezolizumab alone...
February 28, 2024: Nature
#8
JOURNAL ARTICLE
Angela L Rasmussen, Gigi K Gronvall, Anice C Lowen, Felicia Goodrum, James Alwine, Kristian G Andersen, Simon J Anthony, Joel Baines, Arinjay Banerjee, Andrew J Broadbent, Christopher B Brooke, Samuel K Campos, Patrizia Caposio, Arturo Casadevall, Gary C Chan, Anna R Cliffe, Donna Collins-McMillen, Nancy Connell, Blossom Damania, Matthew D Daugherty, Kari Debbink, Terence S Dermody, Daniel DiMaio, W Paul Duprex, Michael Emerman, Denise A Galloway, Robert F Garry, Stephen A Goldstein, Alexander L Greninger, Amy L Hartman, Brenda G Hogue, Stacy M Horner, Peter J Hotez, Jae U Jung, Jeremy P Kamil, Stephanie M Karst, Lou Laimins, Seema S Lakdawala, Igor Landais, Michael Letko, Brett Lindenbach, Shan-Lu Liu, Micah Luftig, Grant McFadden, Andrew Mehle, Juliet Morrison, Anne Moscona, Elke Mühlberger, Joshua Munger, Karl Münger, Eain Murphy, Christopher J Neufeldt, Janko Z Nikolich, Christine M O'Connor, Andrew Pekosz, Sallie R Permar, Julie K Pfeiffer, Saskia V Popescu, John G Purdy, Vincent R Racaniello, Charles M Rice, Jonathan A Runstadler, Martin J Sapp, Rona S Scott, Gregory A Smith, Erin M Sorrell, Emily Speranza, Daniel Streblow, Scott A Tibbetts, Zsolt Toth, Koenraad Van Doorslaer, Susan R Weiss, Elizabeth A White, Timothy M White, Christiane E Wobus, Michael Worobey, Satoko Yamaoka, Andrew Yurochko
No abstract text is available yet for this article.
February 9, 2024: Journal of Virology
#9
JOURNAL ARTICLE
Cornelia Baum, Laurent Audigé, Thomas Stojanov, Sebastian A Müller, Christian Candrian, Andreas M Müller, Claudio Rosso, Lena Fankhauser, Gernot Willscheid, Philipp Moroder, Doruk Akgün, Victor Danzinger, Henry Gebauer, Jan-Philipp Imiolczyk, Katrin Karpinski, Lucca Lacheta, Marvin Minkus, Alp Paksoy, Eduardo Samaniego, Kathi Thiele, Isabella Weiss, Thomas Suter, Julia Müller-Lebschi, Sebastian Mueller, Markus Saner, Claudia Haag-Schumacher, Giorgio Tamborrini-Schütz, Mai Lan Dao Trong, Carlos Buitrago-Tellez, Julian Hasler, Ulf Riede, Sandra Weber, Beat Moor, Matthias Biner, Sarah Fournier, Nicolas Gallusser, Deborah Marietan, Sebastien Pawlak, Christoph Spormann, Britta Hansen, Nadja Mamisch, Holger Durchholz, Jakob Bräm, Gregory Cunningham, Abed Kourhani, Sarah Ossipow, Patricia Simao, Alexandre Lädermann, Rainer Egli, Stephanie Erdbrink, Remy Flückiger, Paolo Lombardo, Tawan Pinworasarn, Philipp Scacchi, Johannes Weihs, Matthias Zumstein, Matthias Flury, Ralph Berther, Christine Ehrmann, Larissa Hübscher, David Schwappach, Karim Eid, Susanne Bensler, Yannick Fritz, Nisha Grünberger, Philipp Kriechling, Daniel Langthaler, Richard Niehaus, Raffaela Nobs, Emanuel Benninger, Quintin de Groot, Aleksis Doert, Sebastian Ebert, Philemon Grimm, Fabian Mottier, Markus Pisan, Jan Schätz, Ariane Schwank, Julian Wiedenbach, Markus Scheibel, Laurent Audigé, Frederik Bellmann, Daniela Brune, Marije de Jong, Stefan Diermayr, David Endell, Marco Etter, Florian Freislederer, Nikitas Gkikopoulos, Michael Glanzmann, Cécile Grobet, Christian Jung, Fabrizio Moro, Philipp Moroder, Ralph Ringer, Jan Schätz, Hans-Kaspar Schwyzer, Béatrice Weber, Martina Wehrli, Barbara Wirth, Manuela Nötzli, Anne Franz, Jörg Oswald, Birgit Steiger, Yacine Ameziane, Christopher Child, Giovanni Spagna, Christian Candrian, Filippo Del Grande, Pietro Feltri, Giuseppe Filardo, Francesco Marbach, Florian Schönweger, Bernhard Jost, Michael Badulescu, Stephanie Lüscher, Fabian Napieralski, Lena Öhrström, Martin Olach, Jan Rechsteiner, Jörg Scheler, Christian Spross, Vilijam Zdravkovic, Matthias A Zumstein, Adrian Chlasta, Kate Gerber, Annabel Hayoz, Julia Müller-Lebschi, Frederick Schuster, Karl Wieser, Paul Borbas, Samy Bouaicha, Roland Camenzind, Sabrina Catanzaro, Christian Gerber, Florian Grubhofer, Anita Hasler, Bettina Hochreiter, Roy Marcus, Farah Selman, Reto Sutter, Sabine Wyss, Christian Appenzeller-Herzog, Soheila Aghlmandi, Ilona Ahlborn, Cornelia Baum, Franziska Eckers, Kushtrim Grezda, Simone Hatz, Sabina Hunziker, Thomas Stojanov, Mohy Taha, Giorgio Tamborrini-Schütz, Andreas Marc Mueller
BACKGROUND: Arthroscopic rotator cuff repair (ARCR) is among the most commonly performed orthopaedic procedures. Several factors-including age, sex, and tear severity-have been identified as predictors for outcome after repair. The influence of the tear etiology on functional and structural outcome remains controversial. PURPOSE: To investigate the influence of tear etiology (degenerative vs traumatic) on functional and structural outcomes in patients with supraspinatus tendon tears...
February 2024: American Journal of Sports Medicine
#10
JOURNAL ARTICLE
Michael Lehrke, Georg Fuernau, Christian Jung, Florian Kahles, Julia Moellmann, Ingo Eitel, Nathalie Thelemann, Steffen Desch, Karl Werdan, Uwe Zeymer, Volker Adams, Nikolaus Marx, Holger Thiele
BACKGROUND: Glucagon-like peptide-1 (GLP-1) is a gut-derived peptide secreted in response to nutritional and inflammatory stimuli. Elevated GLP-1 levels predict adverse outcome in patients with acute myocardial infarction or sepsis. GLP-1 holds cardioprotective effects and GLP-1 receptor agonists reduce cardiovascular events in high-risk patients with diabetes. In this study, we aimed to investigate the capacity of GLP-1 to predict outcome in patients with cardiogenic shock (CS) complicating myocardial infarction...
January 3, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
#11
JOURNAL ARTICLE
Angela L Rasmussen, Gigi K Gronvall, Anice C Lowen, Felicia Goodrum, James Alwine, Kristian G Andersen, Simon J Anthony, Joel Baines, Arinjay Banerjee, Andrew J Broadbent, Christopher B Brooke, Samuel K Campos, Patrizia Caposio, Arturo Casadevall, Gary C Chan, Anna R Cliffe, Donna Collins-McMillen, Nancy Connell, Blossom Damania, Matthew D Daugherty, Kari Debbink, Terence S Dermody, Daniel DiMaio, W Paul Duprex, Michael Emerman, Denise A Galloway, Robert F Garry, Stephen A Goldstein, Alexander L Greninger, Amy L Hartman, Brenda G Hogue, Stacy M Horner, Peter J Hotez, Jae U Jung, Jeremy P Kamil, Stephanie M Karst, Lou Laimins, Seema S Lakdawala, Igor Landais, Michael Letko, Brett Lindenbach, Shan-Lu Liu, Micah Luftig, Grant McFadden, Andrew Mehle, Juliet Morrison, Anne Moscona, Elke Mühlberger, Joshua Munger, Karl Münger, Eain Murphy, Christopher J Neufeldt, Janko Z Nikolich, Christine M O'Connor, Andrew Pekosz, Sallie R Permar, Julie K Pfeiffer, Saskia V Popescu, John G Purdy, Vincent R Racaniello, Charles M Rice, Jonathan A Runstadler, Martin J Sapp, Rona S Scott, Gregory A Smith, Erin M Sorrell, Emily Speranza, Daniel Streblow, Scott A Tibbetts, Zsolt Toth, Koenraad Van Doorslaer, Susan R Weiss, Elizabeth A White, Timothy M White, Christiane E Wobus, Michael Worobey, Satoko Yamaoka, Andrew Yurochko
In the United States (US), biosafety and biosecurity oversight of research on viruses is being reappraised. Safety in virology research is paramount and oversight frameworks should be reviewed periodically. Changes should be made with care, however, to avoid impeding science that is essential for rapidly reducing and responding to pandemic threats as well as addressing more common challenges caused by infectious diseases. Decades of research uniquely positioned the US to be able to respond to the COVID-19 crisis with astounding speed, delivering life-saving vaccines within a year of identifying the virus...
January 3, 2024: Journal of Virology
#12
JOURNAL ARTICLE
Wonkyung Jung, Mia Vogel, Karl Cristie F Figuracion, Eeeseung Byun, Hilaire Thompson
PURPOSE: The aim of this study was to explore the perceived meaning of traumatic brain injury (TBI) over the first-year postinjury among older adults and to explore if and how meaning changes. DESIGN: A longitudinal multiple-case study design was used. METHODS: Semistructured face-to-face interviews were completed at 1 week and 1, 3, 6, and 12 months postinjury. Transcripts were analyzed using inductive thematic analysis. RESULTS: Fifty-five interviews were conducted with 12 participants...
December 30, 2023: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
#13
JOURNAL ARTICLE
Maria-Elisabeth Leinweber, Phillip Geisbuesch, Kai Balzer, Thomas Schmandra, Thomas Karl, Sebastian Popp, Johannes Hoffmann, Thomas Schmitz-Rixen, Georg Jung, Kyriakos Oikonomou, Martin Storck, Kai Balzer, Ulrich Kugelmann, Christina Schneider, Michael Engelhardt, Michael Petzold, Barbara Weis-Mueller, Markus Wortmann, Sebastian Popp, Dirk Grotemeyer, Heiner Wenk, Roushanak Shayesteh-Kheslat, Giovanni Torsello, Dittmar Böckler, Katrin Meisenbacher, Johannes Hoffmann, Hubert Schelzig, Yush Roopa, Thomas Strohschneider, Thomas Noppeney, Viktor Reichert, Uwe Lorenz, Karin Pfister, Shoaeddin Damirchi, Tomislav Stojanovic, Alexander Oberhuber, Bernd Lobenstein, Tolga Atilla Sagban, Tomas Pfeiffer, Johann Koller, Christian Sprenger, Thomas Kruschwitz, Claus-Georg Schmedt, Frank Marquardt, Thomas Schmandra, Dorothee Bail
OBJECTIVE: Only 5% of patients with popliteal artery aneurysms (PAAs) are female. Evidence on PAA treatment and outcomes in women is therefore scarce. The POPART Registry provides one of Europe's largest data collections regarding PAA treatment. Data on clinical presentation, aneurysm morphology, and perioperative outcomes after open surgical PAA repair in women will be presented. METHODS: POPART is a multicenter, noninterventional registry for open and endovascular PAA repair, with 42 participating centers in Germany and Luxembourg...
December 23, 2023: Journal of Vascular Surgery
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JOURNAL ARTICLE
Tommaso Nicoletti, Andrea Bink, Birgit Helmchen, Nils Briel, Karl Frontzek, Benjamin Vlad, Ariana Gaspert, Elisabeth Boudriot, Hans Heinrich Jung, Anna Maria Reuss, Michael Weller, Tibor Hortobágyi
Nephropathic cystinosis is a rare autosomal recessive storage disorder caused by CTNS gene mutations, leading to autophagy-lysosomal pathway impairment and cystine crystals accumulation. Neurologic involvement is highly variable and includes both neurodevelopmental and neurodegenerative disturbances, as well as focal neurologic deficits. By presenting longitudinal data of a 28-year-old patient with a large infratentorial lesion, we summarized the pathology, clinical and imaging features of neurological involvement in cystinosis patients...
January 15, 2024: Journal of the Neurological Sciences
#15
JOURNAL ARTICLE
Fabian Voß, Tharusan Thevathasan, Karl Heinrich Scholz, Bernd W Böttiger, Daniel Scheiber, Payam Kabiri, Michael Bernhard, Peter Kienbaum, Christian Jung, Ralf Westenfeld, Carsten Skurk, Christoph Adler, Malte Kelm
BACKGROUND: Out-of-hospital cardiac arrest (OHCA) remains a frequent medical emergency with low survival rates even after a return of spontaneous circulation (ROSC). Growing evidence supports formation of dedicated teams in scenarios like cardiogenic shock to improve prognosis. Thus, the European Resuscitation Council (ERC) recommended introduction of Cardiac Arrest Centers (CAC) in their 2015 guidelines. Here, we aimed to elucidate the effects of newly introduced CACs in Germany regarding survival rate and neurological outcome...
December 5, 2023: Resuscitation
#16
REVIEW
Erik Jung, Karl Gademann
This review discusses small molecule antibiotics approved for clinical use in the time frame 2010-2022. This time span saw the approval of four synthetic antibiotics (bedaquiline, pretomanid, delafloxacin, tedizolid), nine natural product derivatives (ceftaroline fosamil, cefiderocol, plazomicin, omadacycline, eravacycline, sarecycline, lefamulin, dalbavancin, oritavancin), and one natural product (fidaxomicin).
April 26, 2023: Chimia
#17
JOURNAL ARTICLE
Maximilian Nowka, Karl Hilbig, Lukas Schulze, Eggert Jung, Thomas Vietor
Additive manufacturing of components using the material extrusion (MEX) of thermoplastics enables the integration of multiple materials into a single part. This can include functional structures, such as electrically conductive ones. The resulting functional structure properties depend on the process parameters along the entire manufacturing chain. The aim of this investigation is to determine the influence of process parameters in filament production and additive manufacturing on resistivity. Filament is produced from a commercially available composite of polylactide (PLA) with carbon nanotubes (CNT) and carbon black (CB), while the temperature profile and screw speed were varied...
November 17, 2023: Polymers
#18
Scott R Ceresnak, Yaqi Zhang, Xuefeng B Ling, Kuo Jung Su, Qiming Tang, Bo Jin, James Schilling, C James Chou, Zhi Han, Brendan J Floyd, John C Whitin, Kuo Yuan Hwa, Karl G Sylvester, Henry Chubb, Ruben Y Luo, Lu Tian, Harvey J Cohen, Doff B McElhinney
No abstract text is available yet for this article.
November 22, 2023: Biomarker Research
#19
JOURNAL ARTICLE
Matthew Huang, Karl Frohlich, Ehsan Esmaili, Ting Yang, Ling Li, Sunghwan Jung
The cuttlebone, a chambered gas-filled structure found in cuttlefish, serves a crucial role in buoyancy control for the animal. This study investigates the motion of liquid-gas interfaces within cuttlebone-inspired artificial channels. The cuttlebone's unique microstructure, characterized by chambers divided by vertical pillars, exhibits interesting fluid dynamics at small scales while pumping water in and out. Various channels were fabricated with distinct geometries, mimicking cuttlebone features, and subjected to different pressure drops...
October 1, 2023: Biomimetics
#20
JOURNAL ARTICLE
Erik Jung, Anastassia Kraimps, Silvia Dittmann, Tizian Griesser, Jordan Costafrolaz, Yves Mattenberger, Simon Jurt, Patrick H Viollier, Peter Sander, Susanne Sievers, Karl Gademann
Fidaxomicin (Fdx) is a natural product antibiotic with potent activity against Clostridioides difficile and other Gram-positive bacteria such as Mycobacterium tuberculosis. Only few Fdx derivatives have been synthesized and examined for their biological activity in the 50 years since its discovery. Fdx has a well-studied mechanism of action, namely inhibition of the bacterial RNA polymerase. Yet, the targeted organisms harbor different target protein sequences, which poses a challenge for the rational development of new semisynthetic Fdx derivatives...
September 20, 2023: Chembiochem: a European Journal of Chemical Biology
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