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Karl Jung

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https://www.readbyqxmd.com/read/29511247/interactions-mediated-by-a-public-good-transiently-increase-cooperativity-in-growing-pseudomonas-putida-metapopulations
#1
Felix Becker, Karl Wienand, Matthias Lechner, Erwin Frey, Heinrich Jung
Bacterial communities have rich social lives. A well-established interaction involves the exchange of a public good in Pseudomonas populations, where the iron-scavenging compound pyoverdine, synthesized by some cells, is shared with the rest. Pyoverdine thus mediates interactions between producers and non-producers and can constitute a public good. This interaction is often used to test game theoretical predictions on the "social dilemma" of producers. Such an approach, however, underestimates the impact of specific properties of the public good, for example consequences of its accumulation in the environment...
March 6, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29452351/impact-of-treatment-delay-on-mortality-in-st-segment-elevation-myocardial-infarction-stemi-patients-presenting-with-and-without-haemodynamic-instability-results-from-the-german-prospective-multicentre-fitt-stemi-trial
#2
Karl Heinrich Scholz, Sebastian K G Maier, Lars S Maier, Björn Lengenfelder, Claudius Jacobshagen, Jens Jung, Claus Fleischmann, Gerald S Werner, Hans G Olbrich, Rainer Ott, Harald Mudra, Karlheinz Seidl, P Christian Schulze, Christian Weiss, Josef Haimerl, Tim Friede, Thomas Meyer
Aims: The aim of this study was to investigate the effect of contact-to-balloon time on mortality in ST-segment elevation myocardial infarction (STEMI) patients with and without haemodynamic instability. Methods and results: Using data from the prospective, multicentre Feedback Intervention and Treatment Times in ST-Elevation Myocardial Infarction (FITT-STEMI) trial, we assessed the prognostic relevance of first medical contact-to-balloon time in n = 12 675 STEMI patients who used emergency medical service transportation and were treated with primary percutaneous coronary intervention (PCI)...
April 1, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29445001/interventional-treatment-of-severe-tricuspid-regurgitation-early-clinical-experience-in-a-multicenter-observational-first-in-man-study
#3
Alexander Lauten, Hans R Figulla, Axel Unbehaun, Neil Fam, Joachim Schofer, Torsten Doenst, Joerg Hausleiter, Marcus Franz, Christian Jung, Henryk Dreger, David Leistner, Brunilda Alushi, Anja Stundl, Ulf Landmesser, Volkmar Falk, Karl Stangl, Michael Laule
BACKGROUND: Transcatheter caval valve implantation is under evaluation as a treatment option for inoperable patients with severe tricuspid regurgitation (TR). The procedure involves the catheter-based implantation of bioprosthetic valves in the inferior vena cava and superior vena cava to treat symptoms associated with TR. This study is the first to evaluate the feasibility, safety, and efficacy of this interventional concept. METHODS AND RESULTS: Twenty-five patients (mean age, 73...
February 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29423461/how-to-perform-contrast-enhanced-ultrasound-ceus
#4
REVIEW
Christoph F Dietrich, Michalakis Averkiou, Michael Bachmann Nielsen, Richard G Barr, Peter N Burns, Fabrizio Calliada, Vito Cantisani, Byung Choi, Maria C Chammas, Dirk-André Clevert, Michel Claudon, Jean-Michel Correas, Xin-Wu Cui, David Cosgrove, Mirko D'Onofrio, Yi Dong, JohnR Eisenbrey, Teresa Fontanilla, Odd Helge Gilja, Andre Ignee, Christian Jenssen, Yuko Kono, Masatoshi Kudo, Nathalie Lassau, Andrej Lyshchik, Maria Franca Meloni, Fuminori Moriyasu, Christian Nolsøe, Fabio Piscaglia, Maija Radzina, Adrian Saftoiu, Paul S Sidhu, Ioan Sporea, Dagmar Schreiber-Dietrich, Claude B Sirlin, Maria Stanczak, Hans-Peter Weskott, Stephanie R Wilson, Juergen Karl Willmann, Tae Kyoung Kim, Hyun-Jung Jang, Alexandar Vezeridis, Sue Westerway
"How to perform contrast-enhanced ultrasound (CEUS)" provides general advice on the use of ultrasound contrast agents (UCAs) for clinical decision-making and reviews technical parameters for optimal CEUS performance. CEUS techniques vary between centers, therefore, experts from EFSUMB, WFUMB and from the CEUS LI-RADS working group created a discussion forum to standardize the CEUS examination technique according to published evidence and best personal experience. The goal is to standardise the use and administration of UCAs to facilitate correct diagnoses and ultimately to improve the management and outcomes of patients...
January 2018: Ultrasound International Open
https://www.readbyqxmd.com/read/29377740/impact-of-10-sf-6-gas-compared-to-100-air-tamponade-in-descemet-s-membrane-endothelial-keratoplasty
#5
Annekatrin Rickmann, Peter Szurman, Sacha Jung, Karl Thomas Boden, Silke Wahl, Arno Haus, Katrin Boden, Kai Januschowski
PURPOSE: To compare the clinical outcomes following Descemet's membrane endothelial keratoplasty (DMEK) with 100% air tamponade versus 10% sulfur hexafluoride (SF6 ) tamponade. METHODS: Retrospective analysis of 108 consecutive DMEK cases subdivided by anterior chamber tamponade with 54 eyes receiving 10% SF6 and 54 eyes receiving 100% air injection. A post-hoc matched analysis revealed no statistically significant differences between the groups. The main outcome measurements were the complication rate, including intra- and postoperative complications and graft detachment rate requiring re-bubbling...
April 2018: Current Eye Research
https://www.readbyqxmd.com/read/29339520/targeted-knockout-of-a-chemokine-like-gene-increases-anxiety-and-fear-responses
#6
Jung-Hwa Choi, Yun-Mi Jeong, Sujin Kim, Boyoung Lee, Krishan Ariyasiri, Hyun-Taek Kim, Seung-Hyun Jung, Kyu-Seok Hwang, Tae-Ik Choi, Chul O Park, Won-Ki Huh, Matthias Carl, Jill A Rosenfeld, Salmo Raskin, Alan Ma, Jozef Gecz, Hyung-Goo Kim, Jin-Soo Kim, Ho-Chul Shin, Doo-Sang Park, Robert Gerlai, Bradley B Jamieson, Joon S Kim, Karl J Iremonger, Sang H Lee, Hee-Sup Shin, Cheol-Hee Kim
Emotional responses, such as fear and anxiety, are fundamentally important behavioral phenomena with strong fitness components in most animal species. Anxiety-related disorders continue to represent a major unmet medical need in our society, mostly because we still do not fully understand the mechanisms of these diseases. Animal models may speed up discovery of these mechanisms. The zebrafish is a highly promising model organism in this field. Here, we report the identification of a chemokine-like gene family, samdori ( sam ), and present functional characterization of one of its members, sam2 We show exclusive mRNA expression of s am2 in the CNS, predominantly in the dorsal habenula, telencephalon, and hypothalamus...
January 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29284140/effective-connectivity-during-working-memory-and-resting-states-a-dcm-study
#7
Kyesam Jung, Karl J Friston, Chongwon Pae, Hanseul H Choi, Sungho Tak, Yoon Kyoung Choi, Bumhee Park, Chan-A Park, Chaejoon Cheong, Hae-Jeong Park
Although the relationship between resting-state functional connectivity and task-related activity has been addressed, the relationship between task and resting-state directed or effective connectivity - and its behavioral concomitants - remains elusive. We evaluated effective connectivity under an N-back working memory task in 24 participants using stochastic dynamic causal modelling (DCM) of 7 T fMRI data. We repeated the analysis using resting-state data, from the same subjects, to model connectivity among the same brain regions engaged by the N-back task...
April 1, 2018: NeuroImage
https://www.readbyqxmd.com/read/29198914/glut3-addiction-is-a-druggable-vulnerability-for-a-molecularly-defined-subpopulation-of-glioblastoma
#8
Érika Cosset, Sten Ilmjärv, Valérie Dutoit, Kathryn Elliott, Tami von Schalscha, Maria F Camargo, Alexander Reiss, Toshiro Moroishi, Laetitia Seguin, German Gomez, Jung-Soon Moo, Olivier Preynat-Seauve, Karl-Heinz Krause, Hervé Chneiweiss, Jann N Sarkaria, Kun-Liang Guan, Pierre-Yves Dietrich, Sara M Weis, Paul S Mischel, David A Cheresh
While molecular subtypes of glioblastoma (GBM) are defined using gene expression and mutation profiles, we identify a unique subpopulation based on addiction to the high-affinity glucose transporter, Glut3. Although Glut3 is a known driver of a cancer stem cell phenotype, direct targeting is complicated by its expression in neurons. Using established GBM lines and patient-derived stem cells, we identify a subset of tumors within the "proneural" and "classical" subtypes that are addicted to aberrant signaling from integrin αvβ3, which activates a PAK4-YAP/TAZ signaling axis to enhance Glut3 expression...
December 11, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29191323/transcatheter-aortic-valve-replacement-in-pure-native-aortic-valve-regurgitation
#9
MULTICENTER STUDY
Sung-Han Yoon, Tobias Schmidt, Sabine Bleiziffer, Niklas Schofer, Claudia Fiorina, Antonio J Munoz-Garcia, Ermela Yzeiraj, Ignacio J Amat-Santos, Didier Tchetche, Christian Jung, Buntaro Fujita, Antonio Mangieri, Marcus-Andre Deutsch, Timm Ubben, Florian Deuschl, Shingo Kuwata, Chiara De Biase, Timothy Williams, Abhijeet Dhoble, Won-Keun Kim, Enrico Ferrari, Marco Barbanti, E Mara Vollema, Antonio Miceli, Cristina Giannini, Guiherme F Attizzani, William K F Kong, Enrique Gutierrez-Ibanes, Victor Alfonso Jimenez Diaz, Harindra C Wijeysundera, Hidehiro Kaneko, Tarun Chakravarty, Moody Makar, Horst Sievert, Christian Hengstenberg, Bernard D Prendergast, Flavien Vincent, Mohamed Abdel-Wahab, Luis Nombela-Franco, Miriam Silaschi, Giuseppe Tarantini, Christian Butter, Stephan M Ensminger, David Hildick-Smith, Anna Sonia Petronio, Wei-Hsian Yin, Federico De Marco, Luca Testa, Nicolas M Van Mieghem, Brian K Whisenant, Karl-Heinz Kuck, Antonio Colombo, Saibal Kar, Cesar Moris, Victoria Delgado, Francesco Maisano, Fabian Nietlispach, Michael J Mack, Joachim Schofer, Ulrich Schaefer, Jeroen J Bax, Christian Frerker, Azeem Latib, Raj R Makkar
BACKGROUND: Limited data exist about safety and efficacy of transcatheter aortic valve replacement (TAVR) in patients with pure native aortic regurgitation (AR). OBJECTIVES: This study sought to compare the outcomes of TAVR with early- and new-generation devices in symptomatic patients with pure native AR. METHODS: From the pure native AR TAVR multicenter registry, procedural and clinical outcomes were assessed according to VARC-2 criteria and compared between early- and new-generation devices...
December 5, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29163475/critical-role-for-very-long-chain-sphingolipids-in-invariant-natural-killer-t-cell-development-and-homeostasis
#10
Ashish Saroha, Yael Pewzner-Jung, Natalia S Ferreira, Piyush Sharma, Youenn Jouan, Samuel L Kelly, Ester Feldmesser, Alfred H Merrill, François Trottein, Christophe Paget, Karl S Lang, Anthony H Futerman
The role of sphingolipids (SLs) in the immune system has come under increasing scrutiny recently due to the emerging contributions that these important membrane components play in regulating a variety of immunological processes. The acyl chain length of SLs appears particularly critical in determining SL function. Here, we show a role for very-long acyl chain SLs (VLC-SLs) in invariant natural killer T ( i NKT) cell maturation in the thymus and homeostasis in the liver. Ceramide synthase 2-null mice, which lack VLC-SLs, were susceptible to a hepatotropic strain of lymphocytic choriomeningitis virus, which is due to a reduction in the number of i NKT cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29107946/yeast-casein-kinase-2-governs-morphology-biofilm-formation-cell-wall-integrity-and-host-cell-damage-of-candida-albicans
#11
Sook-In Jung, Natalie Rodriguez, Jihyun Irrizary, Karl Liboro, Thania Bogarin, Marlene Macias, Edward Eivers, Edith Porter, Scott G Filler, Hyunsook Park
The regulatory networks governing morphogenesis of a pleomorphic fungus, Candida albicans are extremely complex and remain to be completely elucidated. This study investigated the function of C. albicans yeast casein kinase 2 (CaYck2p). The yck2Δ/yck2Δ strain displayed constitutive pseudohyphae in both yeast and hyphal growth conditions, and formed enhanced biofilm under non-biofilm inducing condition. This finding was further supported by gene expression analysis of the yck2Δ/yck2Δ strain which showed significant upregulation of UME6, a key transcriptional regulator of hyphal transition and biofilm formation, and cell wall protein genes ALS3, HWP1, and SUN41, all of which are associated with morphogenesis and biofilm architecture...
2017: PloS One
https://www.readbyqxmd.com/read/28992408/analysis-and-sensory-evaluation-of-volatile-constituents-of-fresh-blackcurrant-ribes-nigrum-l-fruits
#12
Kathrin Jung, Oxana Fastowski, Iulia Poplacean, Karl-Heinz Engel
Volatile constituents of fresh blackcurrant (Ribes nigrum L.) berries were isolated via vacuum-headspace extraction and analyzed by capillary gas chromatography-mass spectrometry. In agreement with previous studies with frozen fruits, short-chain esters and terpenes were major compound classes. However, rather high concentrations of C6 -compounds (e.g., (E)-hex-2-enal, (Z)-hex-3-enal) constituted a striking difference to data reported for frozen fruits. Frozen storage of blackcurrant berries was shown to result in drastically reduced concentrations of C6 -compounds and a shift of the volatile profile in favor of terpenes...
November 1, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28937824/clinical-comparison-of-two-methods-of-graft-preparation-in-descemet-membrane-endothelial-keratoplasty
#13
Annekatrin Rickmann, Natalia Opitz, Peter Szurman, Karl Thomas Boden, Sascha Jung, Silke Wahl, Arno Haus, Lara-Jil Damm, Kai Januschowski
PURPOSE: Descemet membrane endothelial keratoplasty (DMEK) has been improved over the last decade. The aim of this study was to compare the clinical outcome of the recently introduced liquid bubble method compared to the standard manual preparation. METHODS: This retrospective study evaluated the outcome of 200 patients after DMEK surgery using two different graft preparation techniques. Ninety-six DMEK were prepared by manual dissection and 104 by the novel liquid bubble technique...
January 2018: Current Eye Research
https://www.readbyqxmd.com/read/28878077/irf9-prevents-cd8-t-cell-exhaustion-in-an-extrinsic-manner-during-acute-lymphocytic-choriomeningitis-virus-infection
#14
Magdalena Huber, Tamara Suprunenko, Thomas Ashhurst, Felix Marbach, Hartmann Raifer, Svenja Wolff, Thomas Strecker, Barney Viengkhou, So Ri Jung, Hannah-Lena Obermann, Stefan Bauer, Haifeng C Xu, Philipp A Lang, Adomati Tom, Karl S Lang, Nicholas J C King, Iain L Campbell, Markus J Hofer
Effective CD8(+) T cell responses play an important role in determining the course of a viral infection. Overwhelming antigen exposure can result in suboptimal CD8(+) T cell responses, leading to chronic infection. This altered CD8(+) T cell differentiation state, termed exhaustion, is characterized by reduced effector function, upregulation of inhibitory receptors, and altered expression of transcription factors. Prevention of overwhelming antigen exposure to limit CD8(+) T cell exhaustion is of significant interest for the control of chronic infection...
November 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28869459/modulation-of-the-mesenchymal-stem-cell-migration-capacity-via-preconditioning-with-topographic-microstructure
#15
Zhengdong Li, Xun Xu, Weiwei Wang, Karl Kratz, Xianlei Sun, Jie Zou, Zijun Deng, Friedrich Jung, Manfred Gossen, Nan Ma, Andreas Lendlein
Controlling mesenchymal stem cells (MSCs) behavior is necessary to fully exploit their therapeutic potential. Various approaches are employed to effectively influence the migration capacity of MSCs. Here, topographic microstructures with different microscale roughness were created on polystyrene (PS) culture vessel surfaces as a feasible physical preconditioning strategy to modulate MSC migration. By analyzing trajectories of cells migrating after reseeding, we demonstrated that the mobilization velocity of human adipose derived mesenchymal stem cells (hADSCs) could be promoted by and persisted after brief preconditioning with the appropriate microtopography...
2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28803240/impact-of-body-site-age-and-gender-on-the-collagen-elastin-index-by-noninvasive-in-vivo-vertical-two-photon-microscopy
#16
Carolin Czekalla, Karl-Heinz Schönborn, Nadine Döge, Sora Jung, Maxim E Darvin, Jürgen Lademann, Martina C Meinke
BACKGROUND/AIMS: Extrinsic and intrinsic skin aging is subject to constant remodeling and degradation processes, primarily in components of the extracellular matrix. While collagen fibers thin out during the aging process, the amorphous elastin fibers accumulate. These are essential formative components of the dermis. So far, these processes have been detected in vertical histological sections of invasive biopsies and recently in noninvasive horizontal scans. METHODS: In this pilot study, a modified noninvasive 2-photon microscope was applied to measure the collagen/elastin index of skin in vivo...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28752534/structural-basis-for-substrate-selection-by-the-translocation-and-assembly-module-of-the-%C3%AE-barrel-assembly-machinery
#17
Rebecca S Bamert, Karl Lundquist, Hyea Hwang, Chaille T Webb, Takoya Shiota, Christopher J Stubenrauch, Mathew J Belousoff, Robert J A Goode, Ralf B Schittenhelm, Richard Zimmerman, Martin Jung, James C Gumbart, Trevor Lithgow
The assembly of proteins into bacterial outer membranes is a key cellular process that we are only beginning to understand, mediated by the β-barrel assembly machinery (BAM). Two crucial elements of that machinery are the core BAM complex and the translocation and assembly module (TAM), with each containing a member of the Omp85 superfamily of proteins: BamA in the BAM complex, TamA in the TAM. Here, we used the substrate protein FimD as a model to assess the selectivity of substrate interactions for the TAM relative to those of the BAM complex...
October 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28607447/fam83h-is-involved-in-the-progression-of-hepatocellular-carcinoma-and-is-regulated-by-myc
#18
Kyoung Min Kim, See-Hyoung Park, Jun Sang Bae, Sang Jae Noh, Guo-Zhong Tao, Jung Ryul Kim, Keun Sang Kwon, Ho Sung Park, Byung-Hyun Park, Ho Lee, Myoung Ja Chung, Woo Sung Moon, Karl G Sylvester, Kyu Yun Jang
Recently, the roles of FAM83H in tumorigenesis have been interested and increased expression of FAM83H and MYC in hepatocellular carcinoma (HCC) have been reported. Therefore, we investigated the expression and role of FAM83H in 163 human HCCs and further investigated the relationship between FAM83H and oncogene MYC. The expression of FAM83H is elevated in liver cancer cells, and nuclear expression of FAM83H predicted shorter survival of HCC patients. In HLE and HepG2 HCC cells, knock-down of FAM83H inhibited proliferation and invasive activity of HCC cells...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28541627/sentinel-lymph-node-mapping-with-indocyanine-green-in-vaginal-cancer
#19
In Ok Lee, Jung Yun Lee, Sunghoon Kim, Sang Wun Kim, Young Tae Kim, Eun Ji Nam
OBJECTIVE: Sentinel lymph node (SLN) mapping is being adapted to gynecologic cancer. Higher SLN mapping rates were reported with indocyanine green (ICG) compared to other dyes. The aim of this film is to share our experience of SLN mapping with ICG in vaginal cancer. METHODS: A 40 year-old woman was diagnosed with squamous cell vaginal cancer. About 1.5 cm-sized tumor was located on the posterior vaginal fornix. Preoperatively she was assumed to be stage I vaginal cancer...
July 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28437668/genome-wide-association-study-of-treatment-response-to-venlafaxine-xr-in-generalized-anxiety-disorder
#20
Jeesun Jung, Elisabeth A Tawa, Christine Muench, Allison D Rosen, Karl Rickels, Falk W Lohoff
We conducted the first genome-wide association study (GWAS) in Generalized Anxiety Disorder (GAD) to identify potential predictors of venlafaxine XR treatment outcome. Ninety-eight European American patients participated in a venlafaxine XR clinical trial for GAD, with Hamilton Anxiety Scale (HAM-A) response/remission at 24 weeks as the primary outcome measure. All participants were genotyped with the Illumina PsychChip, and 266,820 common single nucleotide polymorphisms (SNPs) were analyzed. Although no SNPs reached genome-wide significance, 8 SNPs were marginally associated with treatment response/remission and HAM-A reduction at week 12 and 24 (p<0...
August 2017: Psychiatry Research
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