keyword
MENU ▼
Read by QxMD icon Read
search

Karl Jung

keyword
https://www.readbyqxmd.com/read/29107946/yeast-casein-kinase-2-governs-morphology-biofilm-formation-cell-wall-integrity-and-host-cell-damage-of-candida-albicans
#1
Sook-In Jung, Natalie Rodriguez, Jihyun Irrizary, Karl Liboro, Thania Bogarin, Marlene Macias, Edward Eivers, Edith Porter, Scott G Filler, Hyunsook Park
The regulatory networks governing morphogenesis of a pleomorphic fungus, Candida albicans are extremely complex and remain to be completely elucidated. This study investigated the function of C. albicans yeast casein kinase 2 (CaYck2p). The yck2Δ/yck2Δ strain displayed constitutive pseudohyphae in both yeast and hyphal growth conditions, and formed enhanced biofilm under non-biofilm inducing condition. This finding was further supported by gene expression analysis of the yck2Δ/yck2Δ strain which showed significant upregulation of UME6, a key transcriptional regulator of hyphal transition and biofilm formation, and cell wall protein genes ALS3, HWP1, and SUN41, all of which are associated with morphogenesis and biofilm architecture...
2017: PloS One
https://www.readbyqxmd.com/read/28992408/analysis-and-sensory-evaluation-of-volatile-constituents-of-fresh-blackcurrant-ribes-nigrum-l-fruits
#2
Kathrin Jung, Oxana Fastowski, Iulia Poplacean, Karl-Heinz Engel
Volatile constituents of fresh blackcurrant (Ribes nigrum L.) berries were isolated via vacuum-headspace extraction and analyzed by capillary gas chromatography-mass spectrometry. In agreement with previous studies with frozen fruits, short-chain esters and terpenes were major compound classes. However, rather high concentrations of C6-compounds (e.g., (E)-hex-2-enal, (Z)-hex-3-enal) constituted a striking difference to data reported for frozen fruits. Frozen storage of blackcurrant berries was shown to result in drastically reduced concentrations of C6-compounds and a shift of the volatile profile in favor of terpenes...
October 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28937824/clinical-comparison-of-two-methods-of-graft-preparation-in-descemet-membrane-endothelial-keratoplasty
#3
Annekatrin Rickmann, Natalia Opitz, Peter Szurman, Karl Thomas Boden, Sacha Jung, Silke Wahl, Arno Haus, Lara-Jil Damm, Kai Januschowski
PURPOSE: Descemet membrane endothelial keratoplasty (DMEK) has been improved over the last decade. The aim of this study was to compare the clinical outcome of the recently introduced liquid bubble method compared to the standard manual preparation. METHODS: This retrospective study evaluated the outcome of 200 patients after DMEK surgery using two different graft preparation techniques. Ninety-six DMEK were prepared by manual dissection and 104 by the novel liquid bubble technique...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28878077/irf9-prevents-cd8-t-cell-exhaustion-in-an-extrinsic-manner-during-acute-lymphocytic-choriomeningitis-virus-infection
#4
Magdalena Huber, Tamara Suprunenko, Thomas Ashhurst, Felix Marbach, Hartmann Raifer, Svenja Wolff, Thomas Strecker, Barney Viengkhou, So Ri Jung, Hannah-Lena Obermann, Stefan Bauer, Haifeng C Xu, Philipp A Lang, Adomati Tom, Karl S Lang, Nicholas J C King, Iain L Campbell, Markus J Hofer
Effective CD8(+) T cell responses play an important role in determining the course of a viral infection. Overwhelming antigen exposure can result in suboptimal CD8(+) T cell responses, leading to chronic infection. This altered CD8(+) T cell differentiation state, termed exhaustion, is characterized by reduced effector function, upregulation of inhibitory receptors, and altered expression of transcription factors. Prevention of overwhelming antigen exposure to limit CD8(+) T cell exhaustion is of significant interest for the control of chronic infection...
November 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28869459/modulation-of-the-mesenchymal-stem-cell-migration-capacity-via-preconditioning-with-topographic-microstructure
#5
Zhengdong Li, Xun Xu, Weiwei Wang, Karl Kratz, Xianlei Sun, Jie Zou, Zijun Deng, Friedrich Jung, Manfred Gossen, Nan Ma, Andreas Lendlein
Controlling mesenchymal stem cells (MSCs) behavior is necessary to fully exploit their therapeutic potential. Various approaches are employed to effectively influence the migration capacity of MSCs. Here, topographic microstructures with different microscale roughness were created on polystyrene (PS) culture vessel surfaces as a feasible physical preconditioning strategy to modulate MSC migration. By analyzing trajectories of cells migrating after reseeding, we demonstrated that mobilization velocity of human adipose derived mesenchymal stem cells (hADSCs) could be promoted and persisted by brief preconditioning with the appropriate microtopography...
August 28, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28803240/impact-of-body-site-age-and-gender-on-the-collagen-elastin-index-by-noninvasive-in-vivo-vertical-two-photon-microscopy
#6
Carolin Czekalla, Karl-Heinz Schönborn, Nadine Döge, Sora Jung, Maxim E Darvin, Jürgen Lademann, Martina C Meinke
BACKGROUND/AIMS: Extrinsic and intrinsic skin aging is subject to constant remodeling and degradation processes, primarily in components of the extracellular matrix. While collagen fibers thin out during the aging process, the amorphous elastin fibers accumulate. These are essential formative components of the dermis. So far, these processes have been detected in vertical histological sections of invasive biopsies and recently in noninvasive horizontal scans. METHODS: In this pilot study, a modified noninvasive 2-photon microscope was applied to measure the collagen/elastin index of skin in vivo...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28752534/structural-basis-for-substrate-selection-by-the-translocation-and-assembly-module-of-the-%C3%AE-barrel-assembly-machinery
#7
Rebecca S Bamert, Karl Lundquist, Hyea Hwang, Chaille T Webb, Takoya Shiota, Christopher J Stubenrauch, Mathew J Belousoff, Robert J A Goode, Ralf B Schittenhelm, Richard Zimmerman, Martin Jung, James C Gumbart, Trevor Lithgow
The assembly of proteins into bacterial outer membranes is a key cellular process that we are only beginning to understand, mediated by the β-barrel assembly machinery (BAM). Two crucial elements of that machinery are the core BAM complex and the translocation and assembly module (TAM), with each containing a member of the Omp85 superfamily of proteins: BamA in the BAM complex, TamA in the TAM. Here, we used the substrate protein FimD as a model to assess the selectivity of substrate interactions for the TAM relative to those of the BAM complex...
October 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28607447/fam83h-is-involved-in-the-progression-of-hepatocellular-carcinoma-and-is-regulated-by-myc
#8
Kyoung Min Kim, See-Hyoung Park, Jun Sang Bae, Sang Jae Noh, Guo-Zhong Tao, Jung Ryul Kim, Keun Sang Kwon, Ho Sung Park, Byung-Hyun Park, Ho Lee, Myoung Ja Chung, Woo Sung Moon, Karl G Sylvester, Kyu Yun Jang
Recently, the roles of FAM83H in tumorigenesis have been interested and increased expression of FAM83H and MYC in hepatocellular carcinoma (HCC) have been reported. Therefore, we investigated the expression and role of FAM83H in 163 human HCCs and further investigated the relationship between FAM83H and oncogene MYC. The expression of FAM83H is elevated in liver cancer cells, and nuclear expression of FAM83H predicted shorter survival of HCC patients. In HLE and HepG2 HCC cells, knock-down of FAM83H inhibited proliferation and invasive activity of HCC cells...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28541627/sentinel-lymph-node-mapping-with-indocyanine-green-in-vaginal-cancer
#9
In Ok Lee, Jung Yun Lee, Sunghoon Kim, Sang Wun Kim, Young Tae Kim, Eun Ji Nam
OBJECTIVE: Sentinel lymph node (SLN) mapping is being adapted to gynecologic cancer. Higher SLN mapping rates were reported with indocyanine green (ICG) compared to other dyes. The aim of this film is to share our experience of SLN mapping with ICG in vaginal cancer. METHODS: A 40 year-old woman was diagnosed with squamous cell vaginal cancer. About 1.5 cm-sized tumor was located on the posterior vaginal fornix. Preoperatively she was assumed to be stage I vaginal cancer...
July 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28437668/genome-wide-association-study-of-treatment-response-to-venlafaxine-xr-in-generalized-anxiety-disorder
#10
Jeesun Jung, Elisabeth A Tawa, Christine Muench, Allison D Rosen, Karl Rickels, Falk W Lohoff
We conducted the first genome-wide association study (GWAS) in Generalized Anxiety Disorder (GAD) to identify potential predictors of venlafaxine XR treatment outcome. Ninety-eight European American patients participated in a venlafaxine XR clinical trial for GAD, with Hamilton Anxiety Scale (HAM-A) response/remission at 24 weeks as the primary outcome measure. All participants were genotyped with the Illumina PsychChip, and 266,820 common single nucleotide polymorphisms (SNPs) were analyzed. Although no SNPs reached genome-wide significance, 8 SNPs were marginally associated with treatment response/remission and HAM-A reduction at week 12 and 24 (p<0...
April 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28417168/rdx-degradation-in-bioaugmented-model-aquifer-columns-under-aerobic-and-low-oxygen-conditions
#11
Mark E Fuller, Paul B Hatzinger, Charles W Condee, Christina Andaya, Rachel Rezes, Mandy M Michalsen, Fiona H Crocker, Karl J Indest, Carina M Jung, G Alon Blakeney, Jonathan D Istok, Steven A Hammett
Degradation of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in laboratory columns following biostimulation and bioaugmentation was investigated using sediment and groundwater from a contaminated aquifer at a US Navy facility. No RDX degradation was observed following aerobic biostimulation with either fructose or lactate (both 0.1 mM) prior to bioaugmentation. Replicate columns were then bioaugmented with either Gordonia sp. KTR9, Pseudomonas fluorescens I-C (Ps I-C), or both strains. Under aerobic conditions (influent dissolved oxygen (DO) >6 mg/L), RDX was degraded following the addition of fructose, and to a lesser extent with lactate, in columns bioaugmented with KTR9...
July 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28414329/alternatively-activated-macrophages-do-not-synthesize-catecholamines-or-contribute-to-adipose-tissue-adaptive-thermogenesis
#12
Katrin Fischer, Henry H Ruiz, Kevin Jhun, Brian Finan, Douglas J Oberlin, Verena van der Heide, Anastasia V Kalinovich, Natasa Petrovic, Yochai Wolf, Christoffer Clemmensen, Andrew C Shin, Senad Divanovic, Frank Brombacher, Elke Glasmacher, Susanne Keipert, Martin Jastroch, Joachim Nagler, Karl-Werner Schramm, Dasa Medrikova, Gustav Collden, Stephen C Woods, Stephan Herzig, Dirk Homann, Steffen Jung, Jan Nedergaard, Barbara Cannon, Matthias H Tschöp, Timo D Müller, Christoph Buettner
Adaptive thermogenesis is the process of heat generation in response to cold stimulation. It is under the control of the sympathetic nervous system, whose chief effector is the catecholamine norepinephrine (NE). NE enhances thermogenesis through β3-adrenergic receptors to activate brown adipose tissue and by 'browning' white adipose tissue. Recent studies have reported that alternative activation of macrophages in response to interleukin (IL)-4 stimulation induces the expression of tyrosine hydroxylase (TH), a key enzyme in the catecholamine synthesis pathway, and that this activation provides an alternative source of locally produced catecholamines during the thermogenic process...
May 2017: Nature Medicine
https://www.readbyqxmd.com/read/28329875/american-college-of-radiology-contrast-enhanced-ultrasound-liver-imaging-reporting-and-data-system-ceus-li-rads-for-the-diagnosis-of-hepatocellular-carcinoma-a-pictorial-essay
#13
Fabio Piscaglia, Stephanie R Wilson, Andrej Lyshchik, David Cosgrove, Christoph F Dietrich, Hyun-Jung Jang, Tae Kyoung Kim, Veronica Salvatore, Juergen Karl Willmann, Claude B Sirlin, Yuko Kono
No abstract text is available yet for this article.
June 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/28273355/evaluation-of-segmentation-methods-on-head-and-neck-ct-auto-segmentation-challenge-2015
#14
Patrik F Raudaschl, Paolo Zaffino, Gregory C Sharp, Maria Francesca Spadea, Antong Chen, Benoit M Dawant, Thomas Albrecht, Tobias Gass, Christoph Langguth, Marcel Lüthi, Florian Jung, Oliver Knapp, Stefan Wesarg, Richard Mannion-Haworth, Mike Bowes, Annaliese Ashman, Gwenael Guillard, Alan Brett, Graham Vincent, Mauricio Orbes-Arteaga, David Cárdenas-Peña, German Castellanos-Dominguez, Nava Aghdasi, Yangming Li, Angelique Berens, Kris Moe, Blake Hannaford, Rainer Schubert, Karl D Fritscher
PURPOSE: Automated delineation of structures and organs is a key step in medical imaging. However, due to the large number and diversity of structures and the large variety of segmentation algorithms, a consensus is lacking as to which automated segmentation method works best for certain applications. Segmentation challenges are a good approach for unbiased evaluation and comparison of segmentation algorithms. METHODS: In this work, we describe and present the results of the Head and Neck Auto-Segmentation Challenge 2015, a satellite event at the Medical Image Computing and Computer Assisted Interventions (MICCAI) 2015 conference...
March 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/28258407/biodegradation-of-insensitive-munition-formulations-imx101-and-imx104-in-surface-soils
#15
Karl J Indest, Dawn E Hancock, Fiona H Crocker, Jed O Eberly, Carina M Jung, Gary A Blakeney, Jon Brame, Mark A Chappell
The biodegradation potential of insensitive munition melt cast formulations IMX101 and IMX104 was investigated in two unamended training range soils under aerobic and anaerobic growth conditions. Changes in community profiles in soil microcosms were monitored via high-throughput 16S rRNA sequencing over the course of the experiments to infer key microbial phylotypes that may be linked to IMX degradation. Complete anaerobic biotransformation occurred for IMX101 and IMX104 constituents 2,4-dinitroanisole (DNAN) and 3-nitro-1,2,4-triazol-5-one during the 30-day incubation period with Camp Shelby (CS) soil...
July 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28230527/phloem-unloading-in-arabidopsis-roots-is-convective-and-regulated-by-the-phloem-pole-pericycle
#16
Timothy J Ross-Elliott, Kaare H Jensen, Katrine S Haaning, Brittney M Wager, Jan Knoblauch, Alexander H Howell, Daniel L Mullendore, Alexander G Monteith, Danae Paultre, Dawei Yan, Sofia Otero, Matthieu Bourdon, Ross Sager, Jung-Youn Lee, Ykä Helariutta, Michael Knoblauch, Karl J Oparka
In plants, a complex mixture of solutes and macromolecules is transported by the phloem. Here, we examined how solutes and macromolecules are separated when they exit the phloem during the unloading process. We used a combination of approaches (non-invasive imaging, 3D-electron microscopy, and mathematical modelling) to show that phloem unloading of solutes in Arabidopsis roots occurs through plasmodesmata by a combination of mass flow and diffusion (convective phloem unloading). During unloading, solutes and proteins are diverted into the phloem-pole pericycle, a tissue connected to the protophloem by a unique class of 'funnel plasmodesmata'...
February 23, 2017: ELife
https://www.readbyqxmd.com/read/28217433/visual-analogue-scales-vas-measuring-instruments-for-the-documentation-of-symptoms-and-therapy-monitoring-in-cases-of-allergic-rhinitis-in-everyday-health-care-position-paper-of-the-german-society-of-allergology-aeda-and-the-german-society-of-allergy-and-clinical
#17
Ludger Klimek, Karl-Christian Bergmann, Tilo Biedermann, Jean Bousquet, Peter Hellings, Kirsten Jung, Hans Merk, Heidi Olze, Wolfgang Schlenter, Philippe Stock, Johannes Ring, Martin Wagenmann, Wolfgang Wehrmann, Ralph Mösges, Oliver Pfaar
BACKROUND: Visual analogue scales (VAS) are psychometric measuring instruments designed to document the characteristics of disease-related symptom severity in individual patients and use this to achieve a rapid (statistically measurable and reproducible) classification of symptom severity and disease control. VAS can also be used in routine patient history taking and to monitor the course of a chronic disease such as allergic rhinitis (AR). More specifically, the VAS has been used to assess effectiveness of AR therapy in real life, both in intermittent and persistent disease...
2017: Allergo Journal International
https://www.readbyqxmd.com/read/28213024/sanitizer-efficacy-in-preventing-cross-contamination-of-heads-of-lettuce-during-retail-crisping
#18
Yangjin Jung, Hyein Jang, Mengqi Guo, Jingwen Gao, Karl R Matthews
This study was conducted to provide information regarding mitigation of cross-contamination through the use of sanitizer during crisping at retail outlets. Seven non-inoculated heads and one inoculated head (≈5 log CFU/g) of lettuce were placed into commercial sink filled with 76 L of tap water (TW), electrolyzed water (EW, free chlorine: 43 ± 6 ppm), lactic acid and phosphoric acid-based sanitizer (LPA, pH 2.89), or citric acid-based sanitizer (CA, pH 2.78) and soaked for 5 min. Two subsequent batches (eight non-inoculated heads per batch) were soaked in the same solution...
June 2017: Food Microbiology
https://www.readbyqxmd.com/read/28174212/drug-eluting-stents-versus-bare-metal-stents-in-acute-myocardial-infarction-with-cardiogenic-shock
#19
RANDOMIZED CONTROLLED TRIAL
Jakob Ledwoch, Georg Fuernau, Steffen Desch, Ingo Eitel, Christian Jung, Suzanne de Waha, Janine Poess, Steffen Schneider, Gerhard Schuler, Karl Werdan, Uwe Zeymer, Holger Thiele
OBJECTIVES: The aim of the present study was to assess the outcome of patients with acute myocardial infarction (AMI) complicated by cardiogenic shock (CS) receiving drug-eluting stents (DES) compared with bare-metal stents (BMS). Data comparing these two stent technologies in AMI with CS were limited. METHODS: A total of 783 patients with AMI and CS undergoing early revascularisation were included in the randomised Intra-aortic Balloon Pump in Cardiogenic Shock II trial (n=600) and the associated registry (n=183)...
August 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28095900/post-stroke-dementia-a-comprehensive-review
#20
REVIEW
Milija D Mijajlović, Aleksandra Pavlović, Michael Brainin, Wolf-Dieter Heiss, Terence J Quinn, Hege B Ihle-Hansen, Dirk M Hermann, Einor Ben Assayag, Edo Richard, Alexander Thiel, Efrat Kliper, Yong-Il Shin, Yun-Hee Kim, SeongHye Choi, San Jung, Yeong-Bae Lee, Osman Sinanović, Deborah A Levine, Ilana Schlesinger, Gillian Mead, Vuk Milošević, Didier Leys, Guri Hagberg, Marie Helene Ursin, Yvonne Teuschl, Semyon Prokopenko, Elena Mozheyko, Anna Bezdenezhnykh, Karl Matz, Vuk Aleksić, DafinFior Muresanu, Amos D Korczyn, Natan M Bornstein
Post-stroke dementia (PSD) or post-stroke cognitive impairment (PSCI) may affect up to one third of stroke survivors. Various definitions of PSCI and PSD have been described. We propose PSD as a label for any dementia following stroke in temporal relation. Various tools are available to screen and assess cognition, with few PSD-specific instruments. Choice will depend on purpose of assessment, with differing instruments needed for brief screening (e.g., Montreal Cognitive Assessment) or diagnostic formulation (e...
January 18, 2017: BMC Medicine
keyword
keyword
45202
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"