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Ultra-high risk for psychosis

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https://www.readbyqxmd.com/read/28521060/diagnostic-and-prognostic-significance-of-dsm-5-attenuated-psychosis-syndrome-in-services-for-individuals-at-ultra-high-risk-for-psychosis
#1
Paolo Fusar-Poli, Andrea De Micheli, Marco Cappucciati, Grazia Rutigliano, Cathy Davies, Valentina Ramella-Cravaro, Dominic Oliver, Ilaria Bonoldi, Matteo Rocchetti, Lauren Gavaghan, Rashmi Patel, Philip McGuire
Background: The diagnostic and prognostic significance of the DSM-5-defined Attenuated Psychosis Syndrome (DSM-5-APS) in individuals undergoing an ultra high risk (UHR) clinical assessment for suspicion of psychosis risk is unknown. Methods: Prospective cohort study including all consecutive help-seeking individuals undergoing both a DSM-5-APS and a Comprehensive Assessment of At Risk Mental States (CAARMS 12/2006) assessment for psychosis risk at the Outreach and Support in South London (OASIS) UHR service (March 2013-April 2014)...
May 17, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28498602/treatment-of-people-at-ultra-high-risk-for-psychosis
#2
Alison R Yung
No abstract text is available yet for this article.
June 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/28498576/a-critique-of-the-ultra-high-risk-and-transition-paradigm
#3
Jim van Os, Sinan Guloksuz
The transdiagnostic expression of psychotic experiences in common mental disorder (anxiety/depression/substance use disorder) is associated with a poorer prognosis, and a small minority of people may indeed develop a clinical picture that meets criteria for schizophrenia. However, it appears neither useful nor valid to observe early states of multidimensional psychopathology in young people through the "schizo"-prism, and apply misleadingly simple, unnecessary and inefficient binary concepts of "risk" and "transition"...
June 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/28483103/cytokines-cortisol-and-igf-1-in-first-episode-psychosis-and-ultra-high-risk-males-evidence-for-tnf-%C3%AE-ifn-%C3%AE-%C3%AE-nf-%C3%AE-il-4-deviation
#4
Evangelos Karanikas, Stefanos Manganaris, Evangelos Ntouros, Georgios Floros, Diomidis Antoniadis, Georgios Garyfallos
The aim of the study was to determine circulating cytokines, cortisol and Insulin-like Growth Factor (IGF)-1, known for their involvement in inflammation, in male patients with First Episode Psychosis (FEP) and subjects at Ultra High Risk (UHR) for Psychosis. The FEP group presented increased pro-inflammatory cytokines (TNF-α, IFN-γ, ΤNF-β) as well as increased anti-inflammatory cytokine (IL-4) compared with Healthy Controls (HC). The UHR group showed increased IL-4 against HC. In contrast, none of the groups did show deviation from normality in either cortisol or IGF-1 levels...
April 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28476338/corrigendum-to-self-reported-cannabis-use-is-inconsistent-with-the-results-from-drug-screening-in-youth-at-ultra-high-risk-for-psychosis-in-colorado-schizophr-res-157-0-august-2014-317-318
#5
https://www.readbyqxmd.com/read/28468563/-developmental-aspects-in-the-early-detection-and-intervention-in-clinical-high-risk-states-for-psychosis
#6
Frauke Schultze-Lutter, Stefanie J Schmidt, Petra Walger, Benno G Schimmelmann
Developmental Aspects in the Early Detection and Intervention in Clinical High Risk States for Psychosis The early detection and intervention in psychoses, which are a main source of disability-adjusted life years already in children and adolescents, have made good progress within the past years. In particular the attenuated and transient positive symptoms of the ultra-high risk criteria and the basic symptom criterion "Cognitive Disturbances" open promising routes to an indicated prevention and have recently been considered as diagnostic criteria of a psychosis-risk syndrome by the European Psychiatric Association (EPA)...
May 2017: Praxis der Kinderpsychologie und Kinderpsychiatrie
https://www.readbyqxmd.com/read/28464976/patterns-of-white-matter-microstructure-in-individuals-at-ultra-high-risk-for-psychosis-associations-to-level-of-functioning-and-clinical-symptoms
#7
K Krakauer, B H Ebdrup, B Y Glenthøj, J M Raghava, D Nordholm, L Randers, E Rostrup, M Nordentoft
BACKGROUND: Individuals at ultra-high-risk (UHR) for psychosis present with emerging symptoms and decline in functioning. Previous univariate analyses have indicated widespread white matter (WM) aberrations in multiple brain regions in UHR individuals and patients with schizophrenia. Using multivariate statistics, we investigated whole brain WM microstructure and associations between WM, clinical symptoms, and level of functioning in UHR individuals. METHODS: Forty-five UHR individuals and 45 matched healthy controls (HCs) underwent magnetic resonance diffusion tensor imaging (DTI) at 3 Tesla...
May 3, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28456857/age-effect-on-prevalence-of-ultra-high-risk-for-psychosis-symptoms-replication-in-a-clinical-sample-of-an-early-detection-of-psychosis-service
#8
Frauke Schultze-Lutter, Daniela Hubl, Benno G Schimmelmann, Chantal Michel
Higher frequencies of perceptual and lesser clinical significance of non-perceptual attenuated psychotic symptoms (APS) have been reported by 8- to 15-year-old of the general population compared to 16- to 40-year-old. We examined if such an age-effect can also be detected in a clinical never-psychotic sample (N = 133) referred to a specialized service for clinical suspicion of developing psychosis. APS and brief intermittent psychotic symptoms (BIPS) were assessed using items P1-P3 and P5 (non-perceptual), and P4 (perceptual) of the Structured Interview for Psychosis-Risk Syndromes, current axis-I disorders with the Mini-International Neuropsychiatric Interview, and psychosocial functioning with the Social and Occupational Functioning Assessment Scale...
April 29, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28454920/automated-analysis-of-written-narratives-reveals-abnormalities-in-referential-cohesion-in-youth-at-ultra-high-risk-for-psychosis
#9
Tina Gupta, Susan J Hespos, William S Horton, Vijay A Mittal
Schizophrenia and at-risk populations are suggested to exhibit referential cohesion deficits in language production (e.g., producing fewer pronouns or nouns that clearly link to concepts from previous sentences). Much of this work has focused on transcribed speech samples, while no work to our knowledge has examined referential cohesion in written narratives among ultra high risk (UHR) youth using Coh-Metrix, an automated analysis tool. In the present study, written narratives from 84 individuals (UHR=41, control=43) were examined...
April 25, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28436017/attachment-styles-and-clinical-correlates-in-people-at-ultra-high-risk-for-psychosis
#10
Debra A Russo, Jan Stochl, Joanne Hodgekins, Maria Iglesias-González, Penelope Chipps, Michelle Painter, Peter B Jones, Jesus Perez
Evidence suggests that attachment styles may influence subclinical psychosis phenotypes (schizotypy) and affective disorders and may play a part in the association between psychosis and childhood adversity. However, the role of attachment in the initial stages of psychosis remains poorly understood. Our main aim was to describe and compare attachment styles in 60 individuals at ultra high risk for psychosis (UHR) and a matched sample of 60 healthy volunteers (HV). The HV had lower anxious and avoidant attachment scores than the UHR individuals (p < ...
April 24, 2017: British Journal of Psychology
https://www.readbyqxmd.com/read/28412612/impairment-in-social-functioning-differentiates-youth-meeting-ultra-high-risk-for-psychosis-criteria-from-other-mental-health-help-seekers-a-validation-of-the-italian-version-of-the-global-functioning-social-and-global-functioning-role-scales
#11
Nella Lo Cascio, Martina Curto, Patrizio Pasqualetti, Juliana Fortes Lindau, Nicoletta Girardi, Riccardo Saba, Martina Brandizzi, Elena Monducci, Alice Masillo, Giada Colafrancesco, Andrea Solfanelli, Franco De Crescenzo, Georgios D Kotzalidis, Claudia Dario, Mauro Ferrara, Stefano Vicari, Paolo Girardi, Andrea M Auther, Barbara A Cornblatt, Christoph U Correll, Paolo Fiori Nastro
Social and occupational impairments are present in the schizophrenia prodrome, and poor social functioning predicts transition to psychosis in Ultra-High Risk (UHR) individuals. We aimed to: 1) validate the Italian version of the Global Functioning: Social (GF: S) and Global Functioning: Role (GF: S) scales; 2) evaluate their association with UHR criteria. Participants were 12-21-years-old (age, mean=15.2, standard deviation=2.1, male/female ratio=117/120) nonpsychotic help-seekers, meeting (N=39) or not (N=198) UHR criteria...
April 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28406913/no-age-effect-in-the-prevalence-and-clinical-significance-of-ultra-high-risk-symptoms-and-criteria-for-psychosis-in-22q11-deletion-syndrome-confirmation-of-the-genetically-driven-risk-for-psychosis
#12
MULTICENTER STUDY
Marco Armando, Maude Schneider, Maria Pontillo, Stefano Vicari, Martin Debbané, Frauke Schultze-Lutter, Stephan Eliez
BACKGROUND: The 22q11.2 deletion syndrome (22q11DS) is one of the highest known risk factors for schizophrenia. Thus, the detection of 22q11DS patients at particularly high risk of psychosis is important, yet studies on the clinical significance of the widely used ultra-high risk (UHR) criteria in 22q11DS are inconclusive. Since age was reported to moderate clinical significance of UHR symptoms in community samples, we explored whether age at presentation of UHR symptoms and criteria may explain part of this heterogeneity...
2017: PloS One
https://www.readbyqxmd.com/read/28388455/poverty-low-education-and-the-expression-of-psychotic-like-experiences-in-the-general-population-of-s%C3%A3-o-paulo-brazil
#13
Alexandre Andrade Loch, Camille Chianca, Tania Maria Alves, Elder Lanzani Freitas, Lucas Hortêncio, Julio Cesar Andrade, Martinus Theodorus van de Bilt, Marcos Roberto Fontoni, Mauricio H Serpa, Wagner Farid Gattaz, Wulf Rössler
The aim of our study was to assess psychotic-like experiences in the general population aged 18-30 years old of the city of São Paulo, Brazil. A household survey was conducted with 1950 young-adults randomly drawn from the city's general population. The validated 92-item Portuguese version of the Prodromal Questionnaire (PQ) was used for face-to-face interviews. Latent class analysis was conducted. Mean age was of 24 years; 51.1% of the sample was of women. Mean total score on the PQ was 22.06 (SD=17.16). Considering a suggested cut-off of 14 in the positive subscale, 30...
March 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28351597/neuropsychology-of-subjects-with-ultra-high-risk-uhr-of-psychosis-a-critical-analysis-of-the-literature
#14
C Mam-Lam-Fook, C Danset-Alexandre, L Pedron, I Amado, R Gaillard, M-O Krebs
Cognitive disorders are currently considered as central components of disorders found in schizophrenia and are a major handicap for patients day to day. These disorders appear before the first psychotic episode, in the prodromal phase, during which time the symptoms are below the threshold for psychosis. People with these symptoms are considered as presenting an at-risk mental state (or at ultra-high risk, UHR of psychosis) and their risk for psychotic transition is between 20% and 40% within one year. Despite a number of studies, the chronology in which cognitive disorders appear in relation to the psychotic symptoms has not clearly been established and the study of the links between cognition and symptoms could improve our understanding of psychotic disorders...
March 25, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28348953/cerebello-thalamo-cortical-networks-predict-positive-symptom-progression-in-individuals-at-ultra-high-risk-for-psychosis
#15
Jessica A Bernard, Joseph M Orr, Vijay A Mittal
Prospective longitudinal evaluation of adolescents at ultra-high-risk (UHR) for the development of psychosis enables an enriched neurodevelopmental perspective of disease progression in the absence of many of the factors that typically confound research with formally psychotic patients (antipsychotic medications, drug/alcohol dependence). The cerebellum has been linked to cognitive dysfunction and symptom severity in schizophrenia and recent work from our team suggests that it is a promising target for investigation in UHR individuals as well...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28347521/-detection-and-early-treatment-of-subjects-at-high-risk-of-clinical-psychosis-definitions-and-recommendations
#16
C Michel, E Toffel, S J Schmidt, S Eliez, M Armando, A Solida-Tozzi, F Schultze-Lutter, M Debbané
In children and adolescents, psychotic disorders already represent one of the leading causes of disability-adjusted life years. During the past two decades, early detection of risk for psychosis has been intensively investigated, and in particular, predictive power for early signs of risk has been initiated and translated into clinical practice. In particular, the attenuated and transient positive symptoms of the ultra-high risk criteria, and the basic symptom criterion "cognitive disturbances", open promising routes to an indicated prevention and have recently been considered by the European Psychiatric Association (EPA) as diagnostic criteria of a psychosis-risk syndrome...
March 24, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28326117/impaired-social-and-role-function-in-ultra-high-risk-for-psychosis-and-first-episode-schizophrenia-its-relations-with-negative-symptoms
#17
So Jung Lee, Kyung Ran Kim, Su Young Lee, Suk Kyoon An
OBJECTIVE: Psychosocial dysfunction was a nettlesome of schizophrenia even in their prodromal phase as well as first episode and its relations with psychopathology were not determined. The aim of the present study was to examine whether the social and role function impairment was found in ultra-high risk for psychosis (UHR) individuals as well as first-episode schizophrenia patients and to explore its relations with psychopathology. METHODS: Thirty-seven normal controls, 63 UHR participants and 28 young, first-episode schizophrenia patients were recruited...
March 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28318840/self-reported-sleep-disturbances-associated-with-procedural-learning-impairment-in-adolescents-at-ultra-high-risk-for-psychosis
#18
Jessica R Lunsford-Avery, Derek J Dean, Vijay A Mittal
Sleep disturbance contributes to impaired procedural learning in schizophrenia, yet little is known about this relationship prior to psychosis onset. Adolescents at ultra high-risk (UHR; N=62) for psychosis completed the Pittsburgh Sleep Quality Index (PSQI) and a procedural learning task (Pursuit Rotor). Increased self-reported problems with sleep latency, efficiency, and quality were associated with impaired procedural learning rate. Further, within-sample comparisons revealed that UHR youth reporting better sleep displayed a steeper learning curve than those with poorer sleep...
March 16, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28314681/duration-and-frequency-mismatch-negativity-shows-no-progressive-reduction-in-early-stages-of-psychosis
#19
Daisuke Koshiyama, Kenji Kirihara, Mariko Tada, Tatsuya Nagai, Shinsuke Koike, Motomu Suga, Tsuyoshi Araki, Kiyoto Kasai
The auditory mismatch negativity (MMN) is a component of event-related potentials, which is being increasingly recognized as a candidate biomarker for early stages of psychosis. Although previous cross-sectional studies have demonstrated small MMN amplitude in early stages of psychosis, it remains unknown whether small MMN amplitude is due to progressive reduction during the early course. In this study, we investigated longitudinal changes of MMN in early stages of psychosis. Participant included 14 patients with first-episode psychosis (FEP), 16 individuals with ultra-high risk (UHR), and 16 healthy control subjects (HC)...
March 14, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28294477/identifying-neurocognitive-markers-for-outcome-prediction-of-global-functioning-in-individuals-with-first-episode-and-ultra-high-risk-for-psychosis
#20
Kingo Sawada, Akiko Kanehara, Eisuke Sakakibara, Satoshi Eguchi, Mariko Tada, Yoshihiro Satomura, Motomu Suga, Shinsuke Koike, Kiyoto Kasai
AIM: There is an increasing need for identifying neurocognitive predictors of global functional outcome in early psychosis toward optimizing an early intervention strategy. METHODS: We conducted a longitudinal observational study to investigate an association between neurocognitive assessments at baseline and global functional outcome at an average of 1-year follow up. Participants included ultra-high-risk for psychosis (UHR) individuals who had not converted to psychosis during the follow-up period (UHR-NP) and those with first-episode psychosis (FEP)...
May 2017: Psychiatry and Clinical Neurosciences
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