keyword
MENU ▼
Read by QxMD icon Read
search

Ultra-high risk for psychosis

keyword
https://www.readbyqxmd.com/read/28103519/do-cognitive-schema-mediate-the-association-between-childhood-trauma-and-being-at-ultra-high-risk-for-psychosis
#1
E Appiah-Kusi, H L Fisher, N Petros, R Wilson, V Mondelli, P A Garety, P Mcguire, S Bhattacharyya
Exposure to childhood trauma has been associated with psychotic symptoms, being at ultra-high risk for psychosis (UHR), and psychotic disorders such as schizophrenia. Negative self-beliefs have been shown to partially mediate the relationship between childhood trauma and paranoia and have been shown to be characteristic of patients with psychosis. However, whether the association between childhood trauma and being at high risk of developing psychosis (e.g., UHR) and paranoia symptoms is mediated by altered cognitive schema is unknown and warrants investigation to inform preventive interventions...
January 6, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28095334/predictors-and-mediators-of-trait-anger-across-the-psychosis-continuum-the-role-of-attachment-style-paranoia-and-social-cognition
#2
Hannah Darrell-Berry, Sandra Bucci, Jasper Palmier-Claus, Richard Emsley, Richard Drake, Katherine Berry
Anger in the context of psychosis has a significant impact on treatment outcomes and serious implications for risk management. Understanding mechanisms underlying anger will improve interventions and inform strategies for prevention. This study is the first to examine the relationships between anger and key theoretical drivers across different phases of the psychosis continuum. A battery including measures of theory of mind, attachment, hostile attribution bias, paranoia and anger was administered to 174 participants (14 ultra-high risk, 20 first-episode, 20 established psychosis, 120 non-clinical participants)...
January 4, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28079061/progressive-decline-in-hippocampal-ca1-volume-in-individuals-at-ultra-high-risk-for-psychosis-who-do-not-remit-findings-from-the-longitudinal-youth-at-risk-study
#3
New Fei Ho, Daphne J Holt, Mike Cheung, Juan Eugenio Iglesias, Alex Goh, Mingyuan Wang, Joseph Kw Lim, Joshua de Souza, Joann S Poh, Yuen Mei See, Alison R Adcock, Stephen J Wood, Michael Wl Chee, Jimmy Lee, Juan Zhou
Most individuals identified as ultra high-risk for psychosis (UHR) do not develop frank psychosis. They continue to exhibit subthreshold symptoms, or go on to fully remit. Prior work has shown that the volume of CA1, a subfield of the hippocampus, is selectively reduced in the early stages of schizophrenia. Here, we aimed to determine whether patterns of volume change of CA1 are different in UHR individuals who do or do not achieve symptomatic remission. Structural MRI scans were acquired at baseline and at 1-2 follow-up time points (at 12-month intervals) from 147 UHR and healthy control subjects...
January 12, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28054132/course-of-clinical-high-risk-states-for-psychosis-beyond-conversion
#4
Chantal Michel, Stephan Ruhrmann, Benno G Schimmelmann, Joachim Klosterkötter, Frauke Schultze-Lutter
BACKGROUND: The main focus of research on clinical high-risk states for psychosis (CHR) has been the development of algorithms to predict psychosis. Consequently, other outcomes have been neglected, and little is known about the long-term diagnostic and functional outcome among those not converting to psychosis. METHODS: In a naturalistic study, incidence, persistence, and remission rates of CHR states according to symptomatic ultra-high risk or cognitive disturbances criteria were investigated in 160 of 246 outpatients of an early detection of psychoses service (21...
January 4, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28053130/diagnostic-and-prognostic-significance-of-brief-limited-intermittent-psychotic-symptoms-blips-in-individuals-at-ultra-high-risk
#5
Paolo Fusar-Poli, Marco Cappucciati, Andrea De Micheli, Grazia Rutigliano, Ilaria Bonoldi, Stefania Tognin, Valentina Ramella-Cravaro, Augusto Castagnini, Philip McGuire
BACKGROUND: Brief Limited Intermittent Psychotic Symptoms (BLIPS) are key inclusion criteria to define individuals at ultra high risk for psychosis (UHR). Their diagnostic and prognostic significance is unclear. OBJECTIVES: To address the baseline diagnostic relationship between BLIPS and the ICD-10 categories and examine the longitudinal prognostic impact of clinical and sociodemographic factors. METHODS: Prospective long-term study in UHR individuals meeting BLIPS criteria...
January 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28002511/the-prognostic-and-clinical-significance-of-neuroimagistic-and-neurobiological-vulnerability-markers-in-correlation-with-the-molecular-pharmacogenetic-testing-in-psychoses-and-ultra-high-risk-categories
#6
Laura Alexandra Nussbaum, Lavinia Maria Hogea, Nicoleta Ioana Andreescu, Raluca Claudia Grădinaru, Maria Puiu, Andrei Todica
We approach an integrated, multidisciplinary, innovative research-action model in children and adolescents with psychosis and ultra high-risk categories. Our main focus was: to investigate the prognostic and clinical significance of neuroimagistic and neurobiological vulnerability markers in correlation with the molecular pharmacogenetic testing in psychoses and ultra high-risk categories; the dynamic evaluation of the clinical evolution for the studied groups in correlation with specific neurobiological and neuroimagistic variables and markers...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27992836/deconstructing-vulnerability-for-psychosis-meta-analysis-of-environmental-risk-factors-for-psychosis-in-subjects-at-ultra-high-risk
#7
P Fusar-Poli, M Tantardini, S De Simone, V Ramella-Cravaro, D Oliver, J Kingdon, M Kotlicka-Antczak, L Valmaggia, J Lee, M J Millan, S Galderisi, U Balottin, V Ricca, P McGuire
BACKGROUND: Subjects at ultra high-risk (UHR) for psychosis have an enhanced vulnerability to develop the disorder but the risk factors accounting for this accrued risk are undetermined. METHOD: Systematic review of associations between genetic or environmental risk factors for psychosis that are widely established in the literature and UHR state, based on comparisons to controls. RESULTS: Forty-four studies encompassing 170 independent datasets and 54 risk factors were included...
December 16, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27987484/social-relationships-in-young-adults-at-ultra-high-risk-for-psychosis
#8
Briana L Robustelli, Raeana E Newberry, Mark A Whisman, Vijay A Mittal
Studies suggest that individuals with schizophrenia have smaller social networks and less satisfying relationships. However, much is still unknown about the typical quantity and quality of social relationships in young adults during the ultra high-risk (UHR) period. Investigating these relationships holds significant importance for improving understanding of etiological processes, mapping the social environment, and highlighting treatment targets in a critical period. A total of 85 participants (44 UHR and 41 healthy controls) completed measures examining the participants' social relationships, social support, and loneliness...
January 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27984822/utility-of-risk-status-for-predicting-psychosis-and-related-outcomes-evaluation-of-a-10-year-cohort-of-presenters-to-a-specialised-early-psychosis-community-mental-health-service
#9
Agatha M Conrad, Terry J Lewin, Ketrina A Sly, Ulrich Schall, Sean A Halpin, Mick Hunter, Vaughan J Carr
Psychosis transition rates by those at clinical high risk have been highly variable and few studies have compared service presenters across the full psychosis risk spectrum with respect to medium-term outcomes. A 10-year service cohort was examined (N=1997), comprising all presentations to an early psychosis service for young people experiencing a recent psychotic episode or at increased risk ('Psychological Assistance Service', Newcastle, Australia). Baseline and longitudinal service data (median follow-up =7...
January 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27960147/neural-basis-for-inferring-false-beliefs-and-social-emotions-in-others-among-individuals-with-schizophrenia-and-those-at-ultra-high-risk-for-psychosis
#10
Yosuke Takano, Yuta Aoki, Noriaki Yahata, Yuki Kawakubo, Hideyuki Inoue, Norichika Iwashiro, Tatsunobu Natsubori, Shinsuke Koike, Wataru Gonoi, Hiroki Sasaki, Hidemasa Takao, Kiyoto Kasai, Hidenori Yamasue
Inferring beliefs and social emotions of others has different neural substrates and possibly different roles in the pathophysiology of different clinical phases of schizophrenia. The current study investigated the neural basis for inferring others' beliefs and social emotions, as individual concepts, in 17 subjects at ultra-high risk for psychosis (UHR), 16 patients with schizophrenia and 20 healthy controls. Brain activity significantly differed from normal in both the left superior temporal sulcus (STS) and the inferior frontal gyrus (IFG) in the schizophrenia group while inferring others' beliefs, whereas those of UHR group were in the middle of those in the schizophrenia and healthy-control groups...
January 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27951606/-the-basic-symptom-concept-and-its-influence-on-current-international-research-on-the-prediction-of-psychoses
#11
F Schultze-Lutter
The early detection of psychoses has become increasingly relevant in research and clinic. Next to the ultra-high risk (UHR) approach that targets an immediate risk of developing frank psychosis, the basic symptom approach that targets the earliest possible detection of the developing disorder is being increasingly used worldwide. The present review gives an introduction to the development and basic assumptions of the basic symptom concept, summarizes the results of studies on the specificity of basic symptoms for psychoses in different age groups as well as on studies of their psychosis-predictive value, and gives an outlook on future results...
December 2016: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/27923525/using-clinical-information-to-make-individualized-prognostic-predictions-in-people-at-ultra-high-risk-for-psychosis
#12
Andrea Mechelli, Ashleigh Lin, Stephen Wood, Patrick McGorry, Paul Amminger, Stefania Tognin, Philip McGuire, Jonathan Young, Barnaby Nelson, Alison Yung
Recent studies have reported an association between psychopathology and subsequent clinical and functional outcomes in people at ultra-high risk (UHR) for psychosis. This has led to the suggestion that psychopathological information could be used to make prognostic predictions in this population. However, because the current literature is based on inferences at group level, the translational value of the findings for everyday clinical practice is unclear. Here we examined whether psychopathological information could be used to make individualized predictions about clinical and functional outcomes in people at UHR...
December 4, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27903412/long-term-employment-among-people-at-ultra-high-risk-for-psychosis
#13
Jack Cotter, Ashleigh Lin, Richard J Drake, Andrew Thompson, Barnaby Nelson, Patrick McGorry, Stephen J Wood, Alison R Yung
BACKGROUND: Psychotic disorders are associated with high rates of sustained unemployment, however, little is known about the long-term employment outcome of people at ultra-high risk (UHR) of developing psychosis. We sought to investigate the long-term unemployment rate and baseline predictors of employment status at follow-up in a large UHR cohort. METHOD: 268 UHR patients recruited from the Personal Assessment and Crisis Evaluation clinic in Melbourne, Australia were followed-up over 2-14years after initial presentation to the service...
November 27, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27887781/high-psychosis-liability-is-associated-with-altered-autonomic-balance-during-exposure-to-virtual-reality-social-stressors
#14
Jacqueline Counotte, Roos Pot-Kolder, Arie M van Roon, Olivier Hoskam, Mark van der Gaag, Wim Veling
BACKGROUND: Social stressors are associated with an increased risk of psychosis. Stress sensitisation is thought to be an underlying mechanism and may be reflected in an altered autonomic stress response. Using an experimental Virtual Reality design, the autonomic stress response to social stressors was examined in participants with different liability to psychosis. METHOD: Fifty-five patients with recent onset psychotic disorder, 20 patients at ultra-high risk for psychosis, 42 siblings of patients with psychosis and 53 controls were exposed to social stressors (crowdedness, ethnic minority status and hostility) in a Virtual Reality environment...
November 22, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27863320/the-effect-of-childhood-adversity-on-4-year-outcome-in-individuals-at-ultra-high-risk-for-psychosis-in-the-dutch-early-detection-intervention-evaluation-edie-nl-trial
#15
Tamar C Kraan, Helga K Ising, Marjolein Fokkema, Eva Velthorst, David P G van den Berg, Margot Kerkhoven, Wim Veling, Filip Smit, Don H Linszen, Dorien H Nieman, Lex Wunderink, Nynke Boonstra, Rianne M C Klaassen, Sara Dragt, Judith Rietdijk, Lieuwe de Haan, Mark van der Gaag
Childhood adversity is associated with a range of mental disorders, functional impairment and higher health care costs in adulthood. In this study we evaluated if childhood adversity was predictive of adverse clinical and functional outcomes and health care costs in a sample of patients at ultra-high risk (UHR) for developing a psychosis. Structural Equation Modeling was used to examine the effect of childhood adversity on depression, anxiety, transition to psychosis and overall functioning at 4-year follow-up...
January 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27860294/screening-for-psychosis-risk-among-adolescents-in-child-and-adolescent-mental-health-services-a-description-of-the-first-step-with-the-16-item-version-of-the-prodromal-questionnaire-pq-16
#16
Yvonne de Jong, Cornelis L Mulder, Albert E Boon, Mathijs Deen, Maarten van 't Hof, Mark van der Gaag
AIM: Although the 16-item version of the Prodromal Questionnaire (PQ-16) is used as a screener in the early detection of psychosis risk, little is known about PQ-16 scores among adolescents referred to the Child and Adolescent Mental Health Services. We assessed such scores in adolescents referred to these services in the Netherlands, and also their associations with age, gender, diagnosis and level of functioning. METHODS: The PQ-16 was added to regular intake procedures...
November 9, 2016: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/27828960/cortical-morphology-differences-in-subjects-at-increased-vulnerability-for-developing-a-psychotic-disorder-a-comparison-between-subjects-with-ultra-high-risk-and-22q11-2-deletion-syndrome
#17
Geor Bakker, Matthan W A Caan, Wilhelmina A M Vingerhoets, Fabiana da Silva-Alves, Mariken de Koning, Erik Boot, Dorien H Nieman, Lieuwe de Haan, Oswald J Bloemen, Jan Booij, Thérèse A M J van Amelsvoort
INTRODUCTION: Subjects with 22q11.2 deletion syndrome (22q11DS) and subjects with ultra-high risk for psychosis (UHR) share a risk of approximately 30% to develop a psychotic disorder. Studying these groups helps identify biological markers of pathophysiological processes involved in the development of psychosis. Total cortical surface area (cSA), total cortical grey matter volume (cGMV), cortical thickness (CT), and local gyrification index (LGI) of the cortical structure have a distinct neurodevelopmental origin making them important target markers to study in relation to the development of psychosis...
2016: PloS One
https://www.readbyqxmd.com/read/27824119/intake-of-7-8-dihydroxyflavone-during-juvenile-and-adolescent-stages-prevents-onset-of-psychosis-in-adult-offspring-after-maternal-immune-activation
#18
Mei Han, Ji-Chun Zhang, Wei Yao, Chun Yang, Tamaki Ishima, Qian Ren, Min Ma, Chao Dong, Xu-Feng Huang, Kenji Hashimoto
Prenatal infection and subsequent abnormal neurodevelopment of offspring is involved in the etiology of schizophrenia. Brain-derived neurotrophic factor (BDNF) and its high affinity receptor, tropomyosin receptor kinase B (TrkB) signaling plays a key role in the neurodevelopment. Pregnant mice exposed to polyriboinosinic-polyribocytidylic acid [poly(I:C)] causes schizophrenia-like behavioral abnormalities in their offspring at adulthood. Here we found that the juvenile offspring of poly(I:C)-treated mice showed cognitive deficits, as well as reduced BDNF-TrkB signaling in the prefrontal cortex (PFC)...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27821204/cannabis-induced-attenuated-psychotic-symptoms-implications-for-prognosis-in-young-people-at-ultra-high-risk-for-psychosis
#19
M J McHugh, P D McGorry, A R Yung, A Lin, S J Wood, J A Hartmann, B Nelson
BACKGROUND: Cannabis use shows a robust dose-dependent relationship with psychosis risk among the general population. Despite this, it has been difficult to link cannabis use with risk for transitioning to a psychotic disorder among individuals at ultra-high risk (UHR) for psychosis. The present study examined UHR transition risk as a function of cannabis use characteristics which vary substantially between individuals including age of first use, cannabis abuse severity and a history of cannabis-induced attenuated psychotic symptoms (APS)...
November 8, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27779285/-prognostic-modelling-and-proactive-intervention-in-psychosis-efficacy-and-cost-effectiveness
#20
M van der Gaag, H Ising, J Lokkerbol, F Smit
Diagnoses have heterogeneous outcomes, varying from good to extremely poor. There is a need to single out an ultra-high-risk group of individuals who have illnesses that might well end unfavourably or who might later develop serious psychopathology.<br/> AIM: To devise a screening instrument that can identify a group of individuals who run a very high risk of developing a first-episode psychosis, and to create a type of intervention that can modify the course of the illness.<br/> METHOD: We developed a short screening instrument (PQ-16) and were able to ascertain its predictive value...
2016: Tijdschrift Voor Psychiatrie
keyword
keyword
45199
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"