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https://www.readbyqxmd.com/read/29669224/evaluation-of-intussusception-after-monovalent-rotavirus-vaccination-in-africa
#1
Jacqueline E Tate, Jason M Mwenda, George Armah, Bhavin Jani, Richard Omore, Ayesheshem Ademe, Hilda Mujuru, Evans Mpabalwani, Bagrey Ngwira, Margaret M Cortese, Richard Mihigo, Hope Glover-Addy, Mwajabu Mbaga, Francis Osawa, Amezene Tadesse, Bothwell Mbuwayesango, Julia Simwaka, Nigel Cunliffe, Benjamin A Lopman, Goitom Weldegebriel, Daniel Ansong, David Msuya, Billy Ogwel, Thomas Karengera, Portia Manangazira, Bruce Bvulani, Catherine Yen, Felicitas R Zawaira, Clement T Narh, Lazaro Mboma, Peter Saula, Fasil Teshager, Halle Getachew, Rebecca M Moeti, Christabel Eweronu-Laryea, Umesh D Parashar
BACKGROUND: Postlicensure evaluations have identified an association between rotavirus vaccination and intussusception in several high- and middle-income countries. We assessed the association between monovalent human rotavirus vaccine and intussusception in lower-income sub-Saharan African countries. METHODS: Using active surveillance, we enrolled patients from seven countries (Ethiopia, Ghana, Kenya, Malawi, Tanzania, Zambia, and Zimbabwe) who had intussusception that met international (Brighton Collaboration level 1) criteria...
April 19, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29605206/the-100-most-influential-publications-in-asthma-from-1960-to-2017-a-bibliometric-analysis
#2
REVIEW
Yulan Qu, Chen Zhang, Zhenli Hu, Sha Li, Chen Kong, Yunye Ning, Yan Shang, Chong Bai
BACKGROUND: The area of asthma medicine has produced a large volume of important clinical and scientific papers that can be found in those most influential journals. The purpose of our study was to identify the 100 most cited papers in asthma research and to analyze their characteristics. METHODS: We used the Institute for Scientific Information Web of Knowledge Database to identify the most frequently cited articles published from 1960 to December 2017. Original articles and reviews were included in the study...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29571892/omega-3-polyunsaturated-fatty-acids-and-cardiovascular-health-a-comprehensive-review
#3
REVIEW
Andrew Elagizi, Carl J Lavie, Keri Marshall, James J DiNicolantonio, James H O'Keefe, Richard V Milani
The potential cardiovascular (CV) disease (CVD) benefits of Omega-3 Polyunsaturated Fatty Acids (OM3) have been intensely studied and debated for decades. Initial trials were performed in patients with low use of maximal medical therapy for CVD, and reported significant mortality benefits with the use of 1 g/day OM3 intervention following myocardial infarction (MI). More recent studies, including cohorts of patients receiving modern guideline directed medical therapy for CVD, have often not shown similar benefits with OM3 use...
March 20, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29553422/publication-patterns-on-occupied-palestine-in-four-key-medical-journals-1990-2016-a-descriptive-study
#4
Mads Gilbert
BACKGROUND: The atrocities in Syria have been covered in the four general medical weekly journals in the USA and the UK. Medical journal articles addressing political determinants of public health have rightly described and criticised the international community's failure to enforce humanitarian law while urging global bodies of power to ensure protection of civilians and civilian infrastructure and medical services. Discussions of the political influences on health of people in the occupied Palestinian territory (West Bank and Gaza Strip) seem to be considered politically out-of-bounds by some medical journals...
February 21, 2018: Lancet
https://www.readbyqxmd.com/read/29502095/impact-and-acceptability-of-self-consent-procedures-for-the-school-based-human-papillomavirus-vaccine-a-mixed-methods-study-protocol
#5
Suzanne Audrey, Harriet Batista Ferrer, Joanne Ferrie, Karen Evans, Michael Bell, Julie Yates, Marion Roderick, John MacLeod, Matthew Hickman
INTRODUCTION: The human papillomavirus (HPV) vaccine, administered in early adolescence, can substantially reduce cervical cancer incidence and mortality. However, lack of written parental consent is a key reason why some young women do not receive the vaccine. The national legal framework allows girls to be vaccinated without parental consent provided they are deemed Gillick competent, but there is some reticence about vaccinating without written parental consent. Self-consent procedures are being implemented in Bristol and South Gloucestershire...
March 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29496500/update-in-outpatient-general-internal-medicine-practice-changing-evidence-published-in-2017
#6
REVIEW
Mark L Wieland, Jason H Szostek, Majken T Wingo, Jason A Post, Karen F Mauck
Clinicians are challenged to identify new practice changing articles in the medical literature. To identify the practice-changing articles published in 2017 most relevant to outpatient general internal medicine, five internists reviewed the following sources: 1) titles and abstracts from internal medicine journals with the 7 highest impact factors, including New England Journal of Medicine, Lancet, Journal of the American Medical Association, British Medical Journal, Public Library of Science Medicine, Annals of Internal Medicine, and JAMA-Internal Medicine; 2) synopses and syntheses of individual studies, including collections in American College of Physicians Journal Club, Journal Watch, and Evidence-Based Medicine; 3) databases of synthesis, including Evidence Updates and the Cochrane Library...
February 26, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29463308/reproducibility-of-clinical-research-in-critical-care-a-scoping-review
#7
Daniel J Niven, T Jared McCormick, Sharon E Straus, Brenda R Hemmelgarn, Lianne Jeffs, Tavish R M Barnes, Henry T Stelfox
BACKGROUND: The ability to reproduce experiments is a defining principle of science. Reproducibility of clinical research has received relatively little scientific attention. However, it is important as it may inform clinical practice, research agendas, and the design of future studies. METHODS: We used scoping review methods to examine reproducibility within a cohort of randomized trials examining clinical critical care research and published in the top general medical and critical care journals...
February 21, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29431141/does-tranexamic-acid-lead-to-changes-in-mri-measures-of-brain-tissue-health-in-patients-with-spontaneous-intracerebral-haemorrhage-protocol-for-a-mri-substudy-nested-within-the-double-blind-randomised-controlled-tich-2-trial
#8
Rob A Dineen, Stefan Pszczolkowski, Katie Flaherty, Zhe K Law, Paul S Morgan, Ian Roberts, David J Werring, Rustam Al-Shahi Salman, Tim England, Philip M Bath, Nikola Sprigg
OBJECTIVES: To test whether administration of the antifibrinolytic drug tranexamic acid (TXA) in patients with spontaneous intracerebral haemorrhage (SICH) leads to increased prevalence of diffusion-weighted MRI-defined hyperintense ischaemic lesions (primary hypothesis) or reduced perihaematomal oedema volume, perihaematomal diffusion restriction and residual MRI-defined SICH-related tissue damage (secondary hypotheses). DESIGN: MRI substudy nested within the double-blind randomised controlled Tranexamic Acid for Hyperacute Primary Intracerebral Haemorrhage (TICH)-2 trial (ISRCTN93732214)...
February 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29412437/an-international-position-statement-on-the-management-of-frailty-in-diabetes-mellitus-summary-of-recommendations-2017
#9
A J Sinclair, A Abdelhafiz, T Dunning, M Izquierdo, L Rodriguez Manas, I Bourdel-Marchasson, J E Morley, M Munshi, J Woo, B Vellas
AIM: The International Position Statement provides the opportunity to summarise all existing clinical trial and best practice evidence for older people with frailty and diabetes. It is the first document of its kind and is intended to support clinical decisions that will enhance safety in management and promote high quality care. METHODS: The Review Group sought evidence from a wide range of studies that provide sufficient confidence (in the absence of grading) for the basis of each recommendation...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29329525/reporting-of-heterogeneity-of-treatment-effect-in-cohort-studies-a-review-of-the-literature
#10
Meryl Dahan, Caroline Scemama, Raphael Porcher, David J Biau
BACKGROUND: This article corresponds to a literature review and analyze how heterogeneity of treatment (HTE) is reported and addressed in cohort studies and to evaluate the use of the different measures to HTE analysis. METHODS: prospective cohort studies, in English language, measuring the effect of a treatment (pharmacological, interventional, or other) published among 119 core clinical journals (defined by the National Library of Medicine) in the last 16 years were selected in the following data source: Medline...
January 12, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29306063/many-randomized-clinical-trials-may-not-be-justified-a-cross-sectional-analysis-of-the-ethics-and-science-of-randomized-clinical-trials
#11
Julie De Meulemeester, Mark Fedyk, Lucas Jurkovic, Michael Reaume, Dar Dowlatshahi, Grant Stotts, Michel Shamy
OBJECTIVE: We have proposed that three scientific criteria are important for the ethical justification of randomized clinical trials (RCTs): (1) they should be designed around a clear hypothesis; (2) uncertainty should exist around that hypothesis; (3) that uncertainty should be as established through a systematic review. We hypothesized that the majority of a sample of recently published RCTs would not explicitly incorporate these criteria, therefore rendering them potentially unjustified on scientific grounds...
January 3, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29281975/a-survey-of-prevalence-of-narrative-and-systematic-reviews-in-five-major-medical-journals
#12
Clovis Mariano Faggion, Nikolaos P Bakas, Jason Wasiak
BACKGROUND: Systematic reviews may provide less biased evidence than narrative reviews because they observe a strict methodology, similarly to primary studies. Hence, for clinical research questions, systematic reviews should be the study design of choice. It would be important to evaluate the prevalence and characteristics of narrative and systematic reviews published in prominent medical journals. Researchers and clinicians give great value to articles published in such scientific journals...
December 28, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29275030/testosterone-and-cardiovascular-health
#13
REVIEW
Andrew Elagizi, Tobias S Köhler, Carl J Lavie
There is an ongoing debate in the medical community regarding the effects of testosterone on cardiovascular (CV) health. For decades, there has been conflicting evidence regarding the association of endogenous testosterone levels and CV disease (CVD) events that has resulted in much debate and confusion among health care providers and patients alike. Testosterone therapy has become increasingly widespread, and after the emergence of studies that reported increased CVD events in patients receiving testosterone therapy, the US Food and Drug Administration (FDA) released a warning statement about testosterone and its potential risk regarding CV health...
January 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29239150/gender-differences-in-septic-intensive-care-unit-patients
#14
Francesco Campanelli, Giovanni Landoni, Luca Cabrini, Alberto Zangrillo
BACKGROUND: The world population is mostly male at birth, although there is a shift in predominance over 55 years of age with more females than males. Male gender was recently hypothesized to be a risk factor for sepsis and septic shock; the reasons and the consequences of this odd discrepancy are yet a matter of debate. We investigated the percentage of males and females in a large number of trials performed on septic adult patients admitted to Intensive Care Units. METHODS: We analysed all the multicentre randomized controlled trials ever published in peer-reviewed Journals reporting a significant effect on mortality in intensive care unit septic adult patients; furthermore, we retrieved all the manuscripts dealing with sepsis or septic shock patients published in the last 3 years in the three medical Journals with the highest impact factor...
December 13, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29221458/a-cohort-examination-to-establish-reporting-of-the-remit-and-function-of-trial-steering-committees-in-randomised-controlled-trials
#15
Elizabeth J Conroy, Barbara Arch, Nicola L Harman, J Athene Lane, Steff C Lewis, John Norrie, Matthew R Sydes, Carrol Gamble
BACKGROUND: The DAMOCLES project established a widely used Data Monitoring Committee (DMC) Charter for randomised controlled trials (RCTs). Typically, within the UK, the DMC is advisory and recommends to another executive body; the Trial Steering Committee (TSC). Despite the executive role of the TSC, the CONSORT Statement does not explicitly require reporting of TSC activity, although is included as an example of good reporting. A lack of guidance on TSC reporting can impact transparency of trial oversight, ultimately leading to a misunderstanding regarding role and, subsequently, further variation in practice...
December 8, 2017: Trials
https://www.readbyqxmd.com/read/29170309/12-a-multi-centre-randomised-feasibility-study-evaluating-the-impact-of-a-prognostic-model-for-management-of-blunt-chest-wall-trauma-patients-stumbl-trial
#16
Ceri Battle, Hayley Hutchings, Zoe Abbott, Claire O'neill, Sam Groves, Alan Watkins, Fiona Lecky, Sally Jones, James Gagg, Rick Body, Phillip Evans
INTRODUCTION: A new prognostic model has been developed and externally validated, the aim of which is to assist in the management of the blunt chest wall trauma patient in the Emergency Department (ED). A definitive randomised controlled trial (impact trial), is required to assess the clinical and cost effectiveness of the new model, before it can be accepted in clinical practice. The purpose of this trial is to assess the feasibility and acceptability of such a definitive trial and inform its design...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29161267/sugar-industry-sponsorship-of-germ-free-rodent-studies-linking-sucrose-to-hyperlipidemia-and-cancer-an-historical-analysis-of-internal-documents
#17
Cristin E Kearns, Dorie Apollonio, Stanton A Glantz
In 1965, the Sugar Research Foundation (SRF) secretly funded a review in the New England Journal of Medicine that discounted evidence linking sucrose consumption to blood lipid levels and hence coronary heart disease (CHD). SRF subsequently funded animal research to evaluate sucrose's CHD risks. The objective of this study was to examine the planning, funding, and internal evaluation of an SRF-funded research project titled "Project 259: Dietary Carbohydrate and Blood Lipids in Germ-Free Rats," led by Dr...
November 2017: PLoS Biology
https://www.readbyqxmd.com/read/29149153/analysis-of-reporting-bias-in-vertebral-augmentation
#18
Douglas P Beall, Sean M Tutton, Kieran Murphy, Wayne Olan, Christopher Warner, Jack B Test
Osteoporotic vertebral compression fractures (OVCFs) are a significant cause of morbidity and mortality in the United States and worldwide, with estimates of 750,000 to 1.5 million occurring annually. As the elderly population continues to increase, the incidence of OVCFs will continue to rise, as will the morbidity and mortality associated with this condition. Vertebral augmentation (VA) was almost universally accepted as the appropriate treatment modality prior to 2 sham trials published in 2009 by the New England Journal of Medicine (NEJM)...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29101129/dissemination-of-2014-dual-antiplatelet-therapy-dapt-trial-results-a-systematic-review-of-scholarly-and-media-attention-over-7-months
#19
Melissa K Sharp, Romana Haneef, Philippe Ravaud, Isabelle Boutron
OBJECTIVE: To explore how the results from the 2014 dual antiplatelet therapy (DAPT) trial were disseminated to the scientific community and online media. DESIGN: A a systematic review of scholarly and public attention surrounding the DAPT study. SETTINGS: Data were collected from the ISI Web of Knowledge, Google Scholar, PubMed Commons, EurekAlert, the DAPT study website (www.daptstudy.org) and the New England Journal of Medicine website (for scholarly attention) and Altmetric Explorer, Snap Bird, YouTube (for public attention) citing DAPT study results appearing from 16 November 2014 to 10 June 2015...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29100609/economic-evaluations-of-alcohol-prevention-interventions-is-the-evidence-sufficient-a-review-of-methodological-challenges
#20
REVIEW
Sarah R Hill, Luke Vale, David Hunter, Emily Henderson, Yemi Oluboyede
Public health interventions have unique characteristics compared to health technologies, which present additional challenges for economic evaluation (EE). High quality EEs that are able to address the particular methodological challenges are important for public health decision-makers. In England, they are even more pertinent given the transition of public health responsibilities in 2013 from the National Health Service to local government authorities where new agents are shaping policy decisions. Addressing alcohol misuse is a globally prioritised public health issue...
December 2017: Health Policy
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