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Skin lesion in chikungunya

Samuel Adouchief, Teemu Smura, Olli Vapalahti, Jussi Hepojoki
Mosquito-transmitted Sindbis virus (SINV) causes fever, skin lesions and musculoskeletal symptoms if transmitted to man. SINV is the prototype virus of genus Alphavirus, which includes other arthritogenic viruses such as chikungunya virus (CHIKV) and Ross River virus (RRV) that cause large epidemics with a considerable public health burden. Until now the human B-cell epitopes have been studied for CHIKV and RRV, but not for SINV. To identify the B-cell epitopes in SINV-infection, we synthetised a library of linear 18-mer peptides covering the structural polyprotein of SINV, and probed it with SINV IgG-positive and IgG-negative serum pools...
September 2016: Journal of General Virology
Claudine E Pang, Eduardo V Navajas, Simon J Warner, Morgan Heisler, Marinko V Sarunic
A 47-year-old man with recent travel to the Caribbean was admitted with acute febrileillness associated with arthralgia and skin rash followed by sudden onset of bilateral visual field defects. Funduscopy revealed subtle bilateral paracentral dark lesions nasal to the fovea best seen on near infrared imaging as hyporeflective, wedge-shaped, paracentral macular lesions. Spectral-domain optical coherence tomography (SD-OCT) through the lesions revealed hyperreflective bands at the level of the outer plexiform layer and outer nuclear layer (ONL), with concomitant attenuation of the underlying external limiting membrane (ELM), ellipsoid zone (EZ), and interdigitation zone (IZ)...
June 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
Ankita Agarwal, Gaurav Joshi, Durga P Nagar, Ajay K Sharma, D Sukumaran, Satish C Pant, Man Mohan Parida, Paban Kumar Dash
Chikungunya virus (CHIKV) is transmitted when infected mosquito probes the host skin. While probing, mosquito saliva is expectorated into host skin along with virus which contains cocktail of molecules having anti-hemostatic and immunomodulatory properties. As mosquito saliva is a critical factor during natural arboviral infection, therefore we investigated mosquito saliva induced cutaneous events that modulate CHIKV infection. The effect of mosquito saliva on CHIKV infection was examined through inoculation of suckling mice subcutaneously with either CHIKV alone or uninfected mosquito bite followed by CHIKV...
June 2016: Infection, Genetics and Evolution
Philippe Gasque, Marie Christine Jaffar-Bandjee
Melanin is a canonical and major defense molecule in invertebrates but its role in mammalian immunity remains unexplored. In contrast, several recent studies have highlighted the emerging innate immune activities of human melanin-producing cells which can sense and respond to bacterial and viral infections. Indeed, the skin is a major portal of entry for pathogens such as arboviruses (Chikungunya, Dengue) and bacteria (mycobacterium leprae, Leptospira spirochetes). Melanocytes of the epidermis could contribute to the phagocytosis of these invading pathogens and to present antigens to competent immune cells...
October 2015: Journal of Infection
K A Seetharam, K Sridevi, P Vidyasagar
Chikungunya fever, a re-emerging RNA viral infection produces different cutaneous manifestations in children compared to adults. 52 children with chikungunya fever, confirmed by positive IgM antibody test were seen during 2009-2010. Pigmentary lesions were common (27/52) followed by vesiculobullous lesions (16/52) and maculopapular lesions (14/52). Vesiculobullous lesions were most common in infants, although rarely reported in adults. Psoriasis was exacerbated in 4 children resulting in more severe forms. In 2 children, guttate psoriasis was observed for the first time...
January 2012: Indian Pediatrics
Jaheersha Pakran, Mamatha George, Najeeba Riyaz, Riyaz Arakkal, Sandhya George, Uma Rajan, Anza Khader, Sumi Thomas, Rahima Abdurahman, Saritha Sasidharanpillai, Lekha Thumbayil
BACKGROUND: Chikungunya (CHIK) is an emerging viral disease with a myriad of cutaneous manifestations. AIMS: The aim of our study was to document the morphology and evolution of skin lesions in cases presenting with fever, purpuric macules and vesiculobullous lesions, to confirm its causative relationship with CHIK, and to investigate further in order to delineate possible mechanisms of bulla formation in these cases. MATERIALS AND METHODS: A prospective, descriptive hospital-based study was carried out at a tertiary health care centre in Kerala...
January 2011: International Journal of Dermatology
Najeeba Riyaz, A Riyaz, E N Abdul Latheef, P M Anitha, K P Aravindan, Anupama S Nair, P Shameera
BACKGROUND: There was a recent epidemic of chikungunya (CKG) in Calicut and other northern districts of Kerala, South India, affecting thousands of people. AIMS: To study the cutaneous manifestations of CKG and to have a serological and histopathological correlation. METHODS: A total of 162 patients (63 males and 99 females) with cutaneous manifestations of CKG were enrolled in the study and serological confirmation was done with capture IgM ELISA for CKG...
November 2010: Indian Journal of Dermatology, Venereology and Leprology
Stéphanie Robin, Duksha Ramful, Julie Zettor, Léon Benhamou, Marie-Christine Jaffar-Bandjee, Jean-Pierre Rivière, Jacques Marichy, Khaled Ezzedine, Jean-Luc Alessandri
INTRODUCTION: The aim of this study was to describe a pediatric case series of Chikungunya infection associated with extensive bullous skin lesions, a severe and unknown form of the disease, during the 2005-2006 outbreak in La Réunion Island. MATERIALS AND METHODS: Retrospective descriptive hospital-based study in children presenting blisters > or = 10% of total body surface area with laboratory-confirmed Chikungunya infection. RESULTS: Eight boys and five girls with a mean age of 3...
January 2010: European Journal of Pediatrics
Joseph J Valamparampil, Shibi Chirakkarot, S Letha, C Jayakumar, K M Gopinathan
OBJECTIVE: To define the clinical manifestations of Chikungunya infection in infants. METHODS: The inclusion criteria was fever (defined as axillary temperature > 99.6 degrees F) with any one of the following features; seizure, loose stools, peripheral cyanosis, skin manifestations or pedal edema in children less than one year. Details of disease from onset of illness till admission were noted and a thorough clinical examination was done at the time of admission...
February 2009: Indian Journal of Pediatrics
Debabrata Bandyopadhyay, Sudip Kumar Ghosh
BACKGROUND: Chikungunya fever (CF) epidemic has recently re-emerged in India on a large scale affecting many parts of the country. We have reviewed the mucocutaneous manifestations of the disease in a number of cases. METHODS: Twenty six serologically proven cases of CF with rash from the district of 24-Paraganas (North) in the eastern Indian state of West Bengal were subjected to detailed clinical study to investigate the chronology and evolution of mucocutaneous lesions, the type and distribution of the rash, and systemic changes...
November 2008: International Journal of Dermatology
Arun C Inamadar, Aparna Palit, V V Sampagavi, S Raghunath, N S Deshmukh
UNLABELLED: BACKGROUND; Chikungunya fever is an Aedes mosquito-borne Arbo viral illness with significant morbidity. METHODS: In a recent outbreak of the disease in south India, the dermatologic manifestations of 145 patients attending a tertiary care hospital were recorded. RESULTS: All age groups were affected, including newborns. Some of the cutaneous features were observed during the acute stage of the illness, and others during convalescence or thereafter...
February 2008: International Journal of Dermatology
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