Milly J McAllister, Rebecca Hall, Robert J Whelan, Lena J Fischer, Cher S Chuah, Peter D Cartlidge, Broc Drury, Duncan G Rutherford, Rodger M Duffin, Jennifer A Cartwright, David A Dorward, Adriano G Rossi, Gwo-Tzer Ho
BACKGROUND: Formylated peptide receptor (FPR)-1 is a G-coupled receptor that senses foreign bacterial and host-derived mitochondrial formylated peptides (FPs), leading to innate immune system activation. AIM: We sought to investigate the role of FPR1-mediated inflammation and its potential as a therapeutic target in inflammatory bowel disease (IBD). METHODS: We characterized FPR1 gene and protein expression in 8 human IBD (~1000 patients) datasets with analysis on disease subtype, mucosal inflammation, and drug response...
January 2024: Crohn's & colitis 360