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JOURNAL ARTICLE
R Mantke, C Schneider, K Weylandt, S Gretschel, F Marusch, R Kube, A Loew, P Jaehn, C Holmberg, R Hunger
BACKGROUND: Pancreatic cancer is the second most frequent cause of death among all forms of cancer in Germany with more than 19,000 deaths per year. The evaluation of the nationwide clinical cancer register aims to depict the reality of treatment and to improve the quality of treatment in the future by targeted analyses. METHOD: The data from the clinical cancer register of Brandenburg-Berlin for the diagnosis years 2001-2017 were analyzed with respect to the treatment of pancreatic cancer...
August 2022: Chirurgie (Heidelb)
#22
JOURNAL ARTICLE
Julianne N Kubes, Ilana Graetz, Zanthia Wiley, Nicole Franks, Ambar Kulshreshtha
Little is known about cancellation frequencies in telemedicine vs. in-person appointments and its impact on clinical outcomes. Our objective was to examine differences between in-person and video telemedicine appointments in terms of cancellation rates by age, race, ethnicity, gender, and insurance, and compare 30-day inpatient hospitalizations rates and 30-day emergency department visit rates between the two visit types. Demographic characteristics and comorbidities for adults scheduled for an Emory Healthcare ambulatory clinic appointment from June 2020 to December 2020 were extracted from the electronic medical record...
December 2021: Preventive Medicine Reports
#23
JOURNAL ARTICLE
J S Teeter, S J Werth, S L Gruber, J C Kube, J A Hagenmaier, J B Allen, C T Herr, M S Brown, D Boler, A C Dilger, Y Zhao, Y Pan, F M Mitloehner
The development of technologies that promote environmental stewardship while maintaining or improving the efficiency of food animal production is essential to the sustainability of producing a food supply to meet the demands of a growing population. As such, Elanco (Greenfield, IN) pursued an environmental indication for a selective β-modulator (lubabegron; LUB). LUB was recently approved by the United States Food and Drug Administration (FDA) to be fed to feedlot cattle during the last 14 to 91 d of the feeding period for reductions in gas emissions/kg of unshrunk final BW and HCW...
November 27, 2021: Journal of Animal Science
#24
JOURNAL ARTICLE
Buvaneshwari Arul, Nandini Suresh, Ranjithkumar Sivarajan, Velmurugan Natanasabapathy
Introduction: Overzealous application of endodontic irrigants affects the root canal dentin mechanical properties. The effect of volume of endodontic irrigants on the microhardness of root canal dentin has not been studied. Aim: This study assessed the effect of volume of endodontic irrigants used in different final irrigation activation techniques on root canal dentin microhardness (RCDM). Methodology: Sixty human maxillary central incisors were embedded in acrylic resin in Kuttler's endodontic cube to the level of cementoenamel junction...
April 2021: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
#25
John C Kube, Ben P Holland, Alyssa B Word, Janet B Allen, Michelle Calvo-Lorenzo, David McKenna, Gary Vogel
[This corrects the article DOI: 10.1093/tas/txab137.].
October 2021: Translational Animal Science
#26
JOURNAL ARTICLE
Christopher Roark, Melissa P Wilson, Sheila Kubes, David Mayer, Laura K Wiley
Background: The 10th revision of International Classification of Disease, Clinical Modification (ICD10-CM) increased the number of codes to identify non-traumatic subarachnoid hemorrhage from 1 to 22. ICD10-CM codes are able to specify the location of aneurysms causing subarachnoid hemorrhage (aSAH); however, it is not clear how frequently or accurately these codes are being used in practice. Objective: To systematically evaluate the usage and accuracy of location-specific ICD10-CM codes for aSAH...
October 2021: Learning Health Systems
#27
JOURNAL ARTICLE
Živko Ćurčić, Andrea Kosovac, Jelena Stepanović, Emil Rekanović, Michael Kube, Bojan Duduk
Rubbery taproot disease of sugar beet (RTD), associated with ' Candidatus Phytoplasma solani', appeared in 2020 on an epidemic scale in northern Serbia and southern Slovakia, situated at opposite edges of the Pannonian Plain. In the affected locations where the disease was assessed, symptomatic sugar beets were analysed for phytoplasma infection. Additionally, multilocus sequence analyses of ' Ca . P. solani' strains on epidemiologically informative marker genes ( tuf , stamp and vmp1 ) were performed. Symptomatic sugar beets from other countries of the Pannonian Plain (Croatia, Hungary and Austria), one sample from Germany, and red beets from Serbia were included in the analyses...
September 14, 2021: Microorganisms
#28
JOURNAL ARTICLE
Eduard Jirkovský, Anna Jirkovská, Hana Bavlovič-Piskáčková, Veronika Skalická, Zuzana Pokorná, Galina Karabanovich, Petra Kollárová-Brázdová, Jan Kubeš, Olga Lenčová-Popelová, Yvona Mazurová, Michaela Adamcová, Alexander R Lyon, Jaroslav Roh, Tomáš Šimůnek, Petra Štěrbová-Kovaříková, Martin Štěrba
BACKGROUND: Anthracycline-induced heart failure has been traditionally attributed to direct iron-catalyzed oxidative damage. Dexrazoxane (DEX)-the only drug approved for its prevention-has been believed to protect the heart via its iron-chelating metabolite ADR-925. However, direct evidence is lacking, and recently proposed TOP2B (topoisomerase II beta) hypothesis challenged the original concept. METHODS: Pharmacokinetically guided study of the cardioprotective effects of clinically used DEX and its chelating metabolite ADR-925 (administered exogenously) was performed together with mechanistic experiments...
September 23, 2021: Circulation. Heart Failure
#29
RANDOMIZED CONTROLLED TRIAL
Saban Elitok, Hermann Kuppe, Prasad Devarajan, Rinaldo Bellomo, Berend Isermann, Sabine Westphal, Johanna Kube, Christian Albert, Martin Ernst, Siegfried Kropf, Anja Haase-Fielitz, Michael Haase
BACKGROUND: Acute kidney injury requiring renal replacement therapy (AKI-RRT) is strongly associated with mortality after cardiac surgery; however, options for early identification of patients at high risk for AKI-RRT are extremely limited. Early after cardiac surgery, the predictive ability for AKI-RRT even of one of the most extensively evaluated novel urinary biomarkers, neutrophil gelatinase-associated lipocalin (NGAL), appears to be only moderate. We aimed to determine whether the NGAL/hepcidin-25 ratio (urinary concentrations of NGAL divided by that of hepcidin-25) early after surgery may compare favorably to NGAL for identification of high-risk patients after cardiac surgery...
December 1, 2021: Anesthesia and Analgesia
#30
JOURNAL ARTICLE
John C Kube, Ben P Holland, Alyssa B Word, Janet B Allen, Michelle Calvo-Lorenzo, David McKenna, Gary Vogel
Lubabegron (LUB; Experior, Elanco, Greenfield, IN, USA) was approved by the U.S. Food and Drug Administration in 2018 and is indicated for the reduction of ammonia (NH3 ) gas emissions·kg-1 body weight (BW) and hot carcass weight (HCW) when fed to feedlot cattle during the final 14 to 91 d of the finishing period. LUB demonstrates antagonistic behavior at the β 1 and β 2 receptor subtypes and agonistic behavior at the β 3 receptor subtype in cattle and is classified by the Center for Veterinary Medicine as a "beta-adrenergic agonist/antagonist...
July 2021: Translational Animal Science
#31
JOURNAL ARTICLE
Jinhee H Hwang, Michael E Spurlock, John C Kube, Xiang Z Li, Stephen B Smith
Chinese hamster ovary cell constructs expressing either the β 1-, β 2- or β 3-adrenergic receptor (AR) were used to determine whether a novel β-AR modulator, lubabegron fumarate (LUB; Experior, Elanco Animal Health) might exert greater potency for a specific β-AR subtype. EC50 values calculated based on cAMP accumulation in dose response curves indicate that LUB is highly selective for the β 3-AR subtype, with an EC50 of 6 × 10-9 M, with no detectible agonistic activity at the β 2-AR. We hypothesized that the accumulation of lipolytic markers would reflect the agonist activity at each of the β-receptor subtypes of the specific ligand; additionally, there would be differences in receptor subtype expression in subcutaneous (s...
August 1, 2021: Journal of Animal Science
#32
JOURNAL ARTICLE
Alana Coleman, Yogesh Vohra, Karen Rascati, Sarah Kubes, Brady Moffett
BACKGROUND: Historically, amoxicillin (Amoxil) has been used as a first-line agent to treat pediatric urinary tract infections (UTIs). However, emerging antibiotic resistance in urinary pathogens has led to broader treatment options, such as cefdinir (Omnicef). This shift in prescribing practices is predicted to vary among place of service and gender due to differing institutional protocols and antimicrobial stewardship practices. OBJECTIVE: This study aimed to describe the antibiotic utilization patterns associated with treating pediatric UTIs in Texas Medicaid patients and to assess the real-world efficacy of the antibiotics that were prescribed...
November 1, 2021: Pediatric Infectious Disease Journal
#33
JOURNAL ARTICLE
Jakub M Kwiecinski, Rachel M Kratofil, Corey P Parlet, Bas G J Surewaard, Paul Kubes, Alexander R Horswill
Skin is one of the most common sites of host immune response against Staphylococcus aureus infection. Here, through a combination of in vitro assays, mouse models, and intravital imaging, we find that S. aureus immune evasion in skin is controlled by a cascade composed of the ArlRS two-component regulatory system and its downstream effector, MgrA. S. aureus lacking either ArlRS or MgrA is less virulent and unable to form correct abscess structure due to de-repression of a giant surface protein, Ebh. These S...
July 27, 2021: Cell Reports
#34
JOURNAL ARTICLE
Farzad Goli, Hamidreza Roohafza, Awat Feizi, Ali Gholamrezaei, Mahboubeh Farzanegan, Marsa Hashemi, Tobias Kube, Winfried Rief
Objective: Patients' beliefs and emotions toward an illness can influence their coping responses, illness behaviors, adherence to treatment, quality of life, and even the psychoneuroimmune responses. The aim of present study was to develop and validate a novel questionnaire assessing both rational and irrational beliefs of patients regarding their illness. Method : In a cross sectional methodological study, the items of the Illness Belief Network (IBN) were developed regarding patients and clients' opinions about and attribution of their disease extracted from 400 clinical interviews and were coded based on Leventhal's self-regulation model...
April 2021: Iranian Journal of Psychiatry
#35
JOURNAL ARTICLE
Mahrous Awad, M A El-Desoky, A Ghallab, Jan Kubes, S E Abdel-Mawly, Subhan Danish, Disna Ratnasekera, Mohammad Sohidul Islam, Milan Skalicky, Marian Brestic, Alaa Baazeem, Saqer S Alotaibi, Talha Javed, Rubab Shabbir, Shah Fahad, Muhammad Habib Ur Rahman, Ayman El Sabagh
Accumulation of heavy metals (HMs) by ornamental plants (OPs) from contaminated agriculture soils is a unique technique that can efficiently reduce the metal load in the food chain. Amaranthus tricolor L. has attractive characteristics acquiring a higher growth rate and large biomass when grown at heavy metal contaminated soils. Site-specific detailed information is not available on the use of A. tricolor plant in metal phytoremediation from the polluted sites. The study aimed to enhance the uptake of HMs (Pb, Zn, and Cu) via amending poultry litter extract (PLE), vinasse sugarcane (VSC), and humic acid (HA) as natural mobilized organic materials compared to ethylene diamine tetraacetic acid (EDTA), as a common mobilized chemical agent by A...
June 2, 2021: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#36
JOURNAL ARTICLE
Phillip J Rincker, Janet B Allen, Matt Edmonds, Michael S Brown, John C Kube
There is a lack of consistency across the globe in how countries establish tissue ractopamine residue limits and which residue limits are applied to various tissues, particularly for edible noncarcass tissues. Therefore, some U.S. beef slaughter organizations have recommended a 48-h voluntary removal of ractopamine before slaughter to meet residue requirements of specific export countries and maintain international trade. Our objective was to assess the impact of voluntary removal of ractopamine hydrochloride (Optaflexx; Elanco, Greenfield, IN) up to 8 d before slaughter on growth performance and carcass characteristics...
April 2021: Translational Animal Science
#37
JOURNAL ARTICLE
J Zindel, M Peiseler, M Hossain, C Deppermann, W Y Lee, B Haenni, B Zuber, J F Deniset, B G J Surewaard, D Candinas, P Kubes
Most multicellular organisms have a major body cavity that harbors immune cells. In primordial species such as purple sea urchins, these cells perform phagocytic functions but are also crucial in repairing injuries. In mammals, the peritoneal cavity contains large numbers of resident GATA6+ macrophages, which may function similarly. However, it is unclear how cavity macrophages suspended in the fluid phase (peritoneal fluid) identify and migrate toward injuries. In this study, we used intravital microscopy to show that cavity macrophages in fluid rapidly form thrombus-like structures in response to injury by means of primordial scavenger receptor cysteine-rich domains...
March 5, 2021: Science
#38
JOURNAL ARTICLE
Naijia Liu, Tianxing Ma, Chaoqun Liao, Guannan Liu, Rodrigo Miguel Ojeda Mota, Jingbei Liu, Sungwoo Sohn, Sebastian Kube, Shaofan Zhao, Jonathan P Singer, Jan Schroers
Direct measurement of critical cooling rates has been challenging and only determined for a minute fraction of the reported metallic glass forming alloys. Here, we report a method that directly measures critical cooling rate of thin film metallic glass forming alloys in a combinatorial fashion. Based on a universal heating architecture using indirect laser heating and a microstructure analysis this method offers itself as a rapid screening technique to quantify glass forming ability. We use this method to identify glass forming alloys and study the composition effect on the critical cooling rate in the Al-Ni-Ge system where we identified Al51 Ge35 Ni14 as the best glass forming composition with a critical cooling rate of 104 K/s...
February 16, 2021: Scientific Reports
#39
JOURNAL ARTICLE
M Gottschall, F Afzal, A V Anisovich, D Bayadilov, R Beck, M Bichow, K Th Brinkmann, V Crede, M Dieterle, F Dietz, H Dutz, H Eberhardt, D Elsner, R Ewald, K Fornet-Ponse, St Friedrich, F Frommberger, A Gridnev, M Grüner, E Gutz, Ch Hammann, J Hannappel, J Hartmann, W Hillert, Ph Hoffmeister, Ch Honisch, T Jude, S Kammer, H Kalinowsky, I Keshelashvili, P Klassen, F Klein, E Klempt, K Koop, B Krusche, M Kube, M Lang, I Lopatin, P Mahlberg, K Makonyi, V Metag, W Meyer, J Müller, J Müllers, M Nanova, V Nikonov, R Novotny, D Piontek, G Reicherz, T Rostomyan, A Sarantsev, Ch Schmidt, H Schmieden, T Seifen, V Sokhoyan, K Spieker, A Thiel, U Thoma, M Urban, H van Pee, D Walther, Ch Wendel, D Werthmüller, U Wiedner, A Wilson, A Winnebeck, L Witthauer, Y Wunderlich
A measurement of the double-polarization observable E for the reaction <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mi>γ</mml:mi> <mml:mi>p</mml:mi> <mml:mo>→</mml:mo> <mml:msup> <mml:mi>π</mml:mi> <mml:mn>0</mml:mn> </mml:msup> <mml:mi>p</mml:mi> </mml:mrow> </mml:math> is reported. The data were taken with the CBELSA/TAPS experiment at the ELSA facility in Bonn using the Bonn frozen-spin butanol (C <mml:math xmlns:mml="https://www...
2021: The European physical journal. A, Hadrons and nuclei
#40
JOURNAL ARTICLE
Junaid Ansari, Elena Y Senchenkova, Shantel A Vital, Zaki Al Yafeai, Gaganpreet Kaur, Erica M Sparkenbaugh, Anthony Orr, Rafal Pawlinski, Robert P Hebbel, D Neil Granger, Paul Kubes, Felicity N E Gavins
Neutrophils plays a crucial role in the intertwined processes of thrombosis and inflammation. Altered neutrophil phenotype may contribute to inadequate resolution which is known to be a major pathophysiological contributor of thrombo-inflammatory conditions such as Sickle Cell Disease (SCD). The endogenous protein Annexin A1 (AnxA1) facilitates inflammation resolution via Formyl Peptide Receptors (FPRs). We sought to comprehensively elucidate the functional significance of targeting neutrophil dependent AnxA1/FPR2/ALX pathway in SCD...
January 26, 2021: Blood
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