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J Kijas, N Elliot, P Kube, B Evans, N Botwright, H King, C R Primmer, K Verbyla
Farmed Atlantic salmon (Salmo salar) is a globally important production species, including in Australia where breeding and selection has been in progress since the 1960s. The recent development of SNP genotyping platforms means genome-wide association and genomic prediction can now be implemented to speed genetic gain. As a precursor, this study collected genotypes at 218 132 SNPs in 777 fish from a Tasmanian breeding population to assess levels of genetic diversity, the strength of linkage disequilibrium (LD) and imputation accuracy...
October 4, 2016: Animal Genetics
Glenn H Engelman, Patrick M Carry, Kyle M Kubes, Michael J Gleason
OBJECTIVES: Patients presenting with ST-elevation myocardial infarction (STEMI) benefit from rapid cardiac reperfusion therapy. Emergency medical service (EMS) agencies can improve patient outcomes by calling STEMI alerts to the receiving facility. The aim of this study was to evaluate the use of pre-hospital activation systems for suspected ST-elevation myocardial infarctions (STEMI) throughout Colorado. METHODS: A cross sectional, survey design was utilized to collect all data from EMS agencies in Colorado...
October 6, 2016: Postgraduate Medicine
F Linke, M Harenberg, M M Nietert, S Zaunig, F von Bonin, A Arlt, M Szczepanowski, H A Weich, S Lutz, C Dullin, P Janovská, M Krafčíková, L Trantírek, P Ovesná, W Klapper, T Beissbarth, F Alves, V Bryja, L Trümper, J Wilting, D Kube
The interaction between vascular endothelial cells (ECs) and cancer cells is of vital importance to understand tumor dissemination. A paradigmatic cancer to study cell-cell interactions is classical Hodgkin Lymphoma (cHL) owing to its complex microenvironment. The role of the interplay between cHL and ECs remains poorly understood. Here we identify canonical WNT pathway activity as important for the mutual interactions between cHL cells and ECs. We demonstrate that local canonical WNT signaling activates cHL cell chemotaxis toward ECs, adhesion to EC layers and cell invasion using not only the Wnt-inhibitor Dickkopf, tankyrases and casein kinase 1 inhibitors but also knockdown of the lymphocyte enhancer binding-factor 1 (LEF-1) and β-catenin in cHL cells...
October 4, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
F Linke, S Zaunig, M M Nietert, F von Bonin, S Lutz, C Dullin, P Janovská, T Beissbarth, F Alves, W Klapper, V Bryja, T Pukrop, L Trümper, J Wilting, D Kube
Classical Hodgkin lymphoma (cHL) has a typical clinical manifestation, with dissemination involving functionally neighboring lymph nodes. The factors involved in the spread of lymphoma cells are poorly understood. Here we show that cHL cell lines migrate with higher rates compared with non-Hodgkin lymphoma cell lines. cHL cell migration, invasion and adhesion depend on autocrine WNT signaling as revealed by the inhibition of WNT secretion with the porcupine inhibitors Wnt-C59/IWP-2, but did not affect cell proliferation...
June 6, 2016: Oncogene
J J Velasco-Vélez, V Pfeifer, M Hävecker, R Wang, A Centeno, A Zurutuza, G Algara-Siller, E Stotz, K Skorupska, D Teschner, P Kube, P Braeuninger-Weimer, S Hofmann, R Schlögl, A Knop-Gericke
One of the main goals in catalysis is the characterization of solid/gas interfaces in a reaction environment. The electronic structure and chemical composition of surfaces become heavily influenced by the surrounding environment. However, the lack of surface sensitive techniques that are able to monitor these modifications under high pressure conditions hinders the understanding of such processes. This limitation is known throughout the community as the "pressure gap." We have developed a novel experimental setup that provides chemical information on a molecular level under atmospheric pressure and in presence of reactive gases and at elevated temperatures...
May 2016: Review of Scientific Instruments
Maria Münster, Uwe Hanisch, Muin Tuffaha, Rainer Kube, Henry Ptok
BACKGROUND: The examination of as large a number of lymph nodes as possible in rectal carcinoma resectates is important for exact staging. However, after neoadjuvant radiochemotherapy (RCT), it can be difficult to obtain a sufficient number of lymph nodes. We therefore investigated whether staining with methylene blue via the inferior mesenteric artery can lead to an increase in the yield of lymph nodes in rectal carcinoma tissue after neoadjuvant RCT. METHODS: In a prospective, unicentric study rectal carcinoma resectates from three consecutive groups of patients were examined (Group I, no staining; Group II, staining with methylene blue; Group III, again no staining)...
February 2016: World Journal of Surgery
Christian Queckenberg, V Erlinghagen, B C M Baken, S H G Van Os, M Wargenau, V Kubeš, R Peroutka, V Novotný, U Fuhr
PURPOSE: To describe concentration versus time profiles of capecitabine and its metabolites 5'-DFUR, 5'-DFCR and 5-FU, depending on tablet formulation and on frequent and/or relevant genetic polymorphisms of cytidine deaminase, dihydropyrimidine dehydrogenase, thymidylate synthase and methylenetetrahydrofolate reductase (MTHFR). METHODS: In 46 cancer patients on chronic capecitabine treatment, who voluntarily participated in the study, individual therapeutic doses were replaced on four consecutive mornings by the study medication...
November 2015: Cancer Chemotherapy and Pharmacology
Fabio Quaglino, Michael Kube, Maan Jawhari, Yusuf Abou-Jawdah, Christin Siewert, Elia Choueiri, Hana Sobh, Paola Casati, Rosemarie Tedeschi, Marina Molino Lova, Alberto Alma, Piero Attilio Bianco
BACKGROUND: Almond witches'-broom (AlmWB), a devastating disease of almond, peach and nectarine in Lebanon, is associated with 'Candidatus Phytoplasma phoenicium'. In the present study, we generated a draft genome sequence of 'Ca. P. phoenicium' strain SA213, representative of phytoplasma strain populations from different host plants, and determined the genetic diversity among phytoplasma strain populations by phylogenetic analyses of 16S rRNA, groEL, tufB and inmp gene sequences. RESULTS: Sequence-based typing and phylogenetic analysis of the gene inmp, coding an integral membrane protein, distinguished AlmWB-associated phytoplasma strains originating from diverse host plants, whereas their 16S rRNA, tufB and groEL genes shared 100 % sequence identity...
2015: BMC Microbiology
Néva P Meyer, Allan Carrillo-Baltodano, Richard E Moore, Elaine C Seaver
BACKGROUND: Reconstructing the evolutionary history of nervous systems requires an understanding of their architecture and development across diverse taxa. The spiralians encompass diverse body plans and organ systems, and within the spiralians, annelids exhibit a variety of morphologies, life histories, feeding modes and associated nervous systems, making them an ideal group for studying evolution of nervous systems. RESULTS: We describe nervous system development in the annelid Capitella teleta (Blake JA, Grassle JP, Eckelbarger KJ...
2015: Frontiers in Zoology
Andreas H Kramer, Craig N Jenne, David A Zygun, Derek J Roberts, Michael D Hill, Jessalyn K Holodinsky, Stephanie Todd, Paul Kubes, John H Wong
Locally administered tissue plasminogen activator (TPA) accelerates clearance of intraventricular hemorrhage (IVH), but its impact on neurologic outcomes remains unclear and preclinical research suggests it may have pro-inflammatory effects. We randomly allocated patients with ruptured cerebral aneurysms and IVH, treated with endovascular coiling and ventricular drainage, to receive either 2-mg intraventricular TPA or placebo every 12 hours. Cerebrospinal fluid (CSF) and serum cytokine and white blood cell (WBC) concentrations were measured before drug administration and daily for 72 hours...
August 2015: Journal of Cerebral Blood Flow and Metabolism
Andreas H Kramer, Craig Jenne, Jessalyn K Holodinsky, Stephanie Todd, Derek J Roberts, Paul Kubes, David A Zygun, Michael D Hill, Caroline Leger, John H Wong
BACKGROUND: Intraventricular hemorrhage (IVH) frequently complicates spontaneous intracerebral or subarachnoid hemorrhage (SAH). Administration of intraventricular tissue plasminogen activator (TPA) accelerates blood clearance, but optimal dosing has not been clarified. Using a standardized TPA dose, we assessed peak cerebrospinal fluid (CSF) TPA concentrations, the rate at which TPA clears, and the relationship between TPA concentration and biological activity. METHODS: Twelve patients with aneurysmal SAH and IVH, treated with endovascular coiling and ventricular drainage, were randomized to receive either 2 mg intraventricular TPA or placebo every 12 h (five doses)...
December 2015: Neurocritical Care
Andrew W Kirkpatrick, Derek J Roberts, Peter D Faris, Chad G Ball, Paul Kubes, Corina Tiruta, Zhengwen Xiao, Jessalyn K Holodinsky, Paul B McBeth, Christopher J Doig, Craig N Jenne
OBJECTIVE: To determine whether active negative pressure peritoneal therapy with the ABThera temporary abdominal closure device reduces systemic inflammation after abbreviated laparotomy. BACKGROUND: Excessive systemic inflammation after abdominal injury or intra-abdominal sepsis is associated with poor outcomes. METHODS: We conducted a single-center, randomized controlled trial. Forty-five adults with abdominal injury (46.7%) or intra-abdominal sepsis (52...
July 2015: Annals of Surgery
Christian Albert, Johanna Kube, Anja Haase-Fielitz, Annemarie Dittrich, Denny Schanze, Martin Zenker, Hermann Kuppe, Roland Hetzer, Rinaldo Bellomo, Peter R Mertens, Michael Haase
AIM: To assess the association of genetic variants of catecholamine-O-methyltransferase (COMT) genotypes with acute kidney injury (AKI) and tubular stress after open heart surgery. PATIENTS & METHODS: We genotyped 195 patients for the COMT-Val158Met polymorphism and measured creatinine, neutrophil gelatinase-associated lipocalin and midkine. We analyzed the association between such polymorphisms and these kidney-related variables. RESULTS: Nonsignificantly more COMT LL patients developed RIFLE-AKI compared with non-LL patients (p = 0...
2014: Biomarkers in Medicine
J Cikhardt, J Krása, M De Marco, M Pfeifer, A Velyhan, E Krouský, B Cikhardtová, D Klír, K Rezáč, J Ullschmied, J Skála, P Kubeš, J Kravárik
Measurements of the return-current flowing through a solid target irradiated with the sub-nanosecond kJ-class Prague Asterix Laser System is reported. A new inductive target probe was developed which allows us measuring the target current derivative in a kA/ns range. The dependences of the target current on the laser pulse energy for cooper, graphite, and polyethylene targets are reported. The experiment shows that the target current is proportional to the deposited laser energy and is strongly affected by the shot-to-shot fluctuations...
October 2014: Review of Scientific Instruments
K Donat, J Kube, J Dressel, E Einax, M Pfeffer, K Failing
SUMMARY Environmental samples are a cost-saving and easy-to-use approach to diagnose paratuberculosis at the herd level. Detailed knowledge concerning its uncertainties in herds with a low prevalence of Mycobacterium avium spp. paratuberculosis (MAP) is required to design sampling strategies in control programmes. This study aimed to calculate a threshold level of the apparent within-herd prevalence (WHPapp) as determined by individual mycobacterial cultivation (faecal culture; FC) of all cows thus allowing the detection of a herd as MAP-positive at a certain probability level (P d)...
April 2015: Epidemiology and Infection
Tobias M Dantonello, Monika Stark, Beate Timmermann, Jörg Fuchs, Barbara Selle, Christin Linderkamp, Rupert Handgretinger, Rudolf Hagen, Simone Feuchtgruber, Stefanie Kube, Daniel Kosztyla, Bernarda Kazanowska, Ruth Ladenstein, Felix Niggli, Gustaf Ljungman, Stefan S Bielack, Thomas Klingebiel, Ewa Koscielniak
BACKGROUND: Response (tumour volume reduction) to induction chemotherapy has been used to stratify secondary local and systemic treatment of Intergroup Rhabdomyosarcoma Study Group III (IRSG-III) embryonal rhabdomyosarcoma (RME) in consecutive CWS-trials. To evaluate its actual impact we studied response-related treatment and outcomes. PROCEDURE: Patients with IRSG-III RME <21 years and non-response (NR, <33% volume reduction) in five consecutive CWS-trials were analysed and compared with partial responders (PAR, ≥ 33% reduction)...
January 2015: Pediatric Blood & Cancer
J Hartmann, H Dutz, A V Anisovich, D Bayadilov, R Beck, M Becker, Y Beloglazov, A Berlin, M Bichow, S Böse, K-Th Brinkmann, V Crede, M Dieterle, H Eberhardt, D Elsner, K Fornet-Ponse, St Friedrich, F Frommberger, Ch Funke, M Gottschall, A Gridnev, M Grüner, E Gutz, Ch Hammann, J Hannappel, V Hannen, J Herick, W Hillert, Ph Hoffmeister, Ch Honisch, O Jahn, T Jude, A Käser, D Kaiser, H Kalinowsky, F Kalischewski, P Klassen, I Keshelashvili, F Klein, E Klempt, K Koop, B Krusche, M Kube, M Lang, I Lopatin, K Makonyi, F Messi, V Metag, W Meyer, J Müller, M Nanova, V Nikonov, D Novinski, R Novotny, D Piontek, C Rosenbaum, B Roth, G Reicherz, T Rostomyan, A Sarantsev, Ch Schmidt, H Schmieden, R Schmitz, T Seifen, V Sokhoyan, Ph Thämer, A Thiel, U Thoma, M Urban, H van Pee, D Walther, Ch Wendel, U Wiedner, A Wilson, A Winnebeck, L Witthauer, Y Wunderlich
New data on the polarization observables T, P, and H for the reaction γp→pπ(0) are reported. The results are extracted from azimuthal asymmetries when a transversely polarized butanol target and a linearly polarized photon beam are used. The data were taken at the Bonn electron stretcher accelerator ELSA using the CBELSA/TAPS detector. These and earlier data are used to perform a truncated energy-independent partial wave analysis in sliced-energy bins. This energy-independent analysis is compared to the results from energy-dependent partial wave analyses...
August 8, 2014: Physical Review Letters
R Kube, P Mroczkowski
The determination of an optimal treatment protocol for colonic cancer with synchronous incurable metastases remains a challenge, especially if the primary tumor is asymptomatic. Available data on whether resection of the primary tumor means a benefit or a danger to the patient are limited and inhomogeneous. A survival benefit could be shown only in retrospective studies with a bias against primary chemotherapy. The important question of the quality of life (QOL) remains completely unanswered in this respect...
February 2015: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
J Kubeš, P Vítek, K Dědečková, B Ondrová
BACKGROUND: Very late effects of radiotherapy occur within decades after the initial exposure. Their development is induced by low doses of ionizing radiation (from 4 Gy per radiation series) and their clinical manifestations are difficult to distinguish from other independent diseases diagnosed in individuals not formerly treated with radiation. A long time period from the exposure confounds any causal relationships between radiation and adverse events. Still, these side effects not only reduce the patients quality of life but also lead to an early morbidity and mortality, hence generating significant costs in health care and social systems...
2014: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
Christin Siewert, Toni Luge, Bojan Duduk, Erich Seemüller, Carmen Büttner, Sascha Sauer, Michael Kube
'Candidatus Phytoplasma mali' is a phytopathogenic bacterium of the family Acholeplasmataceae assigned to the class Mollicutes. This causative agent of the apple proliferation colonizes in Malus domestica the sieve tubes of the plant phloem resulting in a range of symptoms such as witches'--broom formation, reduced vigor and affecting size and quality of the crop. The disease is responsible for strong economical losses in Europe. Although the genome sequence of the pathogen is available, there is only limited information on expression of selected genes and metabolic key features that have not been examined on the transcriptomic or proteomic level so far...
2014: PloS One
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